IMP: Integrative Multi-species Prediction

Danio rerio

55 known processes

pycard

PYD and CARD domain containing

(Aliases: ASC,zgc:109874,asc1,zAsc,MGC109874)

Entrez: 57923
Ensembl: ENSDARG00000040076
ZFIN: ZDB-GENE-000511-2
UniProtKB: Q4VBV3

Process Predictions
Disease Predictions

pycard biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of innate immune response	GO:0045089	8	0.887	Human Mouse
defense response to bacterium	GO:0042742	22	0.835	Human
protein secretion	GO:0009306	1	0.810	Human Mouse
response to other organism	GO:0051707	97	0.806	Human Mouse
immune system process	GO:0002376	241	0.778	Human Mouse
regulation of biological quality	GO:0065008	263	0.737	Mouse
response to molecule of bacterial origin	GO:0002237	14	0.591	Human
positive regulation of defense response to virus by host	GO:0002230	0	0.591	Mouse
positive regulation of transport	GO:0051050	2	0.583	Human Mouse
immune response	GO:0006955	28	0.540	Human Mouse
response to stress	GO:0006950	263	0.487	Human Mouse
response to external biotic stimulus	GO:0043207	97	0.456	Human Mouse
response to drug	GO:0042493	3	0.422
positive regulation of cellular process	GO:0048522	201	0.419
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.401	Human Mouse
regulation of cell communication	GO:0010646	232	0.392	Human Mouse
regulation of primary metabolic process	GO:0080090	311	0.385
response to bacterium	GO:0009617	58	0.371	Human Mouse
positive regulation of biological process	GO:0048518	253	0.366
positive regulation of programmed cell death	GO:0043068	29	0.361
detection of chemical stimulus involved in sensory perception	GO:0050907	3	0.312
regulation of defense response to virus by host	GO:0050691	1	0.311	Mouse
response to biotic stimulus	GO:0009607	97	0.307	Human Mouse
organelle organization	GO:0006996	227	0.304	Human Mouse
positive regulation of secretion by cell	GO:1903532	1	0.302	Human Mouse
antimicrobial humoral response	GO:0019730	2	0.289
cellular response to organic substance	GO:0071310	105	0.281	Human
cellular response to chemical stimulus	GO:0070887	157	0.268	Human
regulation of i kappab kinase nf kappab signaling	GO:0043122	4	0.242	Human
production of molecular mediator of immune response	GO:0002440	2	0.241
defense response to other organism	GO:0098542	33	0.238	Human Mouse
cognition	GO:0050890	1	0.238
leukocyte homeostasis	GO:0001776	2	0.237
signal transduction	GO:0007165	455	0.232	Human Mouse
positive regulation of cellular component biogenesis	GO:0044089	3	0.224	Mouse
response to lipid	GO:0033993	60	0.223	Human
response to external stimulus	GO:0009605	264	0.222	Human Mouse
response to chemical	GO:0042221	320	0.217	Human
regulation of innate immune response	GO:0045088	11	0.196	Human Mouse
protein metabolic process	GO:0019538	183	0.195
cell cycle process	GO:0022402	53	0.193
cellular response to molecule of bacterial origin	GO:0071219	3	0.167	Human
larval development	GO:0002164	2	0.163
muscle structure development	GO:0061061	196	0.160
phagocytosis	GO:0006909	3	0.157	Mouse
cellular response to external stimulus	GO:0071496	2	0.156
specification of symmetry	GO:0009799	204	0.150
positive regulation of cell communication	GO:0010647	56	0.148	Human Mouse
cellular protein metabolic process	GO:0044267	129	0.142
locomotion	GO:0040011	313	0.129	Mouse
gene expression	GO:0010467	252	0.128	Human Mouse
aging	GO:0007568	2	0.123
establishment of localization	GO:0051234	244	0.121	Human Mouse
positive regulation of multicellular organismal process	GO:0051240	52	0.120	Human Mouse
regulation of signaling	GO:0023051	235	0.120	Human Mouse
defense response to virus	GO:0051607	10	0.118	Human Mouse
heterocycle metabolic process	GO:0046483	290	0.116	Human Mouse
cell cycle	GO:0007049	93	0.116
positive regulation of cytoskeleton organization	GO:0051495	3	0.113	Mouse
positive regulation of cytokine production	GO:0001819	2	0.113	Human Mouse
phagocytosis engulfment	GO:0006911	1	0.113
regulation of multicellular organismal process	GO:0051239	277	0.113	Human Mouse
positive regulation of lipid metabolic process	GO:0045834	1	0.112
cellular macromolecule metabolic process	GO:0044260	391	0.110
positive regulation of cellular metabolic process	GO:0031325	94	0.107
organic cyclic compound metabolic process	GO:1901360	301	0.107	Human Mouse
regulation of erk1 and erk2 cascade	GO:0070372	4	0.106	Human Mouse
striated muscle cell differentiation	GO:0051146	129	0.105
i kappab kinase nf kappab signaling	GO:0007249	4	0.101	Human
peptide metabolic process	GO:0006518	1	0.101
cell morphogenesis involved in differentiation	GO:0000904	195	0.098
positive regulation of cell cycle	GO:0045787	3	0.098
amine metabolic process	GO:0009308	2	0.097
stem cell fate commitment	GO:0048865	1	0.097
negative regulation of cytokine production	GO:0001818	1	0.095	Human
regulation of establishment of protein localization	GO:0070201	4	0.095	Human Mouse
positive regulation of apoptotic process	GO:0043065	29	0.095
positive regulation of immune effector process	GO:0002699	3	0.092
innate immune response	GO:0045087	13	0.092	Human Mouse
brain development	GO:0007420	293	0.090
regulation of protein metabolic process	GO:0051246	56	0.089
regulation of cellular metabolic process	GO:0031323	320	0.089
cytokinesis	GO:0000910	3	0.086
negative regulation of protein phosphorylation	GO:0001933	4	0.085	Human
activation of immune response	GO:0002253	9	0.085	Human Mouse
central nervous system development	GO:0007417	387	0.084
organonitrogen compound metabolic process	GO:1901564	74	0.084	Mouse
myeloid cell homeostasis	GO:0002262	56	0.082
small gtpase mediated signal transduction	GO:0007264	8	0.082
peptide transport	GO:0015833	1	0.081
positive regulation of molecular function	GO:0044093	33	0.081
cellular ketone metabolic process	GO:0042180	11	0.080
gastrulation	GO:0007369	208	0.078
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	2	0.077	Human
rho protein signal transduction	GO:0007266	5	0.077
organic substance transport	GO:0071702	58	0.076	Human Mouse
positive regulation of secretion	GO:0051047	1	0.074	Human Mouse
regulation of production of molecular mediator of immune response	GO:0002700	1	0.073
blood vessel development	GO:0001568	246	0.073
cell morphogenesis	GO:0000902	289	0.072
biosynthetic process	GO:0009058	294	0.068	Human
humoral immune response	GO:0006959	5	0.067
positive regulation of signal transduction	GO:0009967	56	0.067	Human Mouse
regulation of epithelial cell proliferation	GO:0050678	3	0.065
fatty acid transport	GO:0015908	1	0.065
cellular response to lipopolysaccharide	GO:0071222	3	0.063	Human
single organism transport	GO:0044765	206	0.063	Human Mouse
digestive tract development	GO:0048565	265	0.061
transport	GO:0006810	220	0.059	Human Mouse
regulation of immune system process	GO:0002682	34	0.057	Human Mouse
apoptotic process	GO:0006915	116	0.057
negative regulation of response to stimulus	GO:0048585	104	0.056	Human
positive regulation of catalytic activity	GO:0043085	25	0.056
cell surface receptor signaling pathway	GO:0007166	325	0.053	Human
long chain fatty acid transport	GO:0015909	1	0.052
regulation of defense response	GO:0031347	14	0.052	Human Mouse
single organism localization	GO:1902578	225	0.052	Human Mouse
heart contraction	GO:0060047	71	0.052
positive regulation of metabolic process	GO:0009893	108	0.052
response to abiotic stimulus	GO:0009628	122	0.051
response to organic cyclic compound	GO:0014070	51	0.051
lipid digestion	GO:0044241	3	0.051
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.051
regulation of metabolic process	GO:0019222	359	0.050
regulation of response to biotic stimulus	GO:0002831	2	0.050	Mouse
cytoskeleton dependent cytokinesis	GO:0061640	3	0.049
regulation of intracellular signal transduction	GO:1902531	57	0.048	Human Mouse
regulation of developmental process	GO:0050793	247	0.048
ras protein signal transduction	GO:0007265	7	0.048
maintenance of location	GO:0051235	4	0.047
cellular modified amino acid metabolic process	GO:0006575	3	0.047
death	GO:0016265	121	0.046
regulation of response to stimulus	GO:0048583	269	0.045	Human Mouse
positive regulation of lymphocyte mediated immunity	GO:0002708	1	0.045
oligopeptide transport	GO:0006857	1	0.044
regulation of signal transduction	GO:0009966	225	0.043	Human Mouse
tissue remodeling	GO:0048771	4	0.043
homeostatic process	GO:0042592	142	0.043
intracellular signal transduction	GO:0035556	85	0.043	Human Mouse
antibacterial humoral response	GO:0019731	2	0.043
regulation of cellular amine metabolic process	GO:0033238	0	0.042
multicellular organism growth	GO:0035264	4	0.042
cell migration	GO:0016477	237	0.042	Mouse
system process	GO:0003008	185	0.041
vasculature development	GO:0001944	278	0.041
determination of bilateral symmetry	GO:0009855	204	0.041
macromolecule modification	GO:0043412	111	0.040	Human
stem cell maintenance	GO:0019827	4	0.040
cellular protein modification process	GO:0006464	100	0.040	Human
cellular component morphogenesis	GO:0032989	336	0.040
cellular response to endogenous stimulus	GO:0071495	68	0.039
regulation of gene expression	GO:0010468	265	0.039	Human Mouse
protein modification process	GO:0036211	100	0.039	Human
regulation of mapk cascade	GO:0043408	14	0.038	Human Mouse
regulation of cellular component organization	GO:0051128	86	0.038	Human Mouse
regulation of catalytic activity	GO:0050790	55	0.038
epithelial cell differentiation	GO:0030855	116	0.037
regulation of immune effector process	GO:0002697	5	0.037	Mouse
digestive system development	GO:0055123	289	0.036
single organism metabolic process	GO:0044710	217	0.036	Human Mouse
cellular amine metabolic process	GO:0044106	2	0.036
response to virus	GO:0009615	21	0.036	Human Mouse
neuron development	GO:0048666	262	0.035
positive regulation of cellular amine metabolic process	GO:0033240	0	0.035
response to transition metal nanoparticle	GO:1990267	28	0.035
oxoacid metabolic process	GO:0043436	31	0.035
guanosine containing compound catabolic process	GO:1901069	2	0.035	Mouse
homeostasis of number of cells	GO:0048872	62	0.034
regulation of cell cycle	GO:0051726	52	0.034
regulation of protein ubiquitination	GO:0031396	3	0.034
membrane invagination	GO:0010324	1	0.034
regulation of cell activation	GO:0050865	1	0.034	Human Mouse
regulation of molecular function	GO:0065009	70	0.034
response to wounding	GO:0009611	116	0.034	Mouse
skin development	GO:0043588	54	0.034
regulation of cellular ketone metabolic process	GO:0010565	7	0.033
tube morphogenesis	GO:0035239	349	0.033
leukocyte differentiation	GO:0002521	25	0.033
regulation of protein transport	GO:0051223	3	0.032	Human Mouse
positive regulation of notch signaling pathway	GO:0045747	3	0.032
regulation of cellular amino acid metabolic process	GO:0006521	0	0.032
regulation of macromolecule metabolic process	GO:0060255	317	0.032
cellular response to xenobiotic stimulus	GO:0071466	35	0.031
defense response to gram negative bacterium	GO:0050829	8	0.031	Human
dna metabolic process	GO:0006259	27	0.031
positive regulation of protein complex assembly	GO:0031334	2	0.031	Mouse
response to oxygen containing compound	GO:1901700	55	0.030	Human
establishment of localization in cell	GO:0051649	77	0.030	Human Mouse
response to fungus	GO:0009620	25	0.030
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.030	Human
actin filament based process	GO:0030029	64	0.029	Mouse
cell projection morphogenesis	GO:0048858	244	0.029
nuclear division	GO:0000280	23	0.029
positive regulation of cell death	GO:0010942	29	0.029
regulation of actin filament based process	GO:0032970	9	0.029	Mouse
regulation of multicellular organismal development	GO:2000026	223	0.029
regulation of wound healing	GO:0061041	2	0.028
stem cell proliferation	GO:0072089	4	0.028
positive regulation of cellular biosynthetic process	GO:0031328	68	0.028
regulation of multicellular organism growth	GO:0040014	4	0.028
cellular amide metabolic process	GO:0043603	4	0.028
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.028
response to corticosteroid	GO:0031960	1	0.028
zymogen activation	GO:0031638	3	0.027	Mouse
multicellular organismal water homeostasis	GO:0050891	1	0.027
gland development	GO:0048732	143	0.027
cell motility	GO:0048870	244	0.027	Mouse
response to nutrient	GO:0007584	3	0.026
regulation of apoptotic process	GO:0042981	98	0.026
embryo development ending in birth or egg hatching	GO:0009792	271	0.026
heart process	GO:0003015	71	0.026
cellular component movement	GO:0006928	335	0.026	Mouse
regulation of cellular protein metabolic process	GO:0032268	52	0.026
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.026	Human Mouse
regulation of cell death	GO:0010941	103	0.026
regulation of cytokine production	GO:0001817	3	0.026	Human Mouse
single organism organelle organization	GO:1902589	199	0.026	Mouse
spermatid development	GO:0007286	2	0.026
regulation of programmed cell death	GO:0043067	101	0.026
plasma membrane repair	GO:0001778	2	0.025
positive regulation of catabolic process	GO:0009896	4	0.025
nitrogen compound metabolic process	GO:0006807	319	0.025	Human Mouse
programmed cell death	GO:0012501	119	0.025
response to hypoxia	GO:0001666	25	0.025
positive regulation of immune response	GO:0050778	11	0.025	Human Mouse
organic acid metabolic process	GO:0006082	31	0.025
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.024	Human
regulation of cell proliferation	GO:0042127	37	0.024	Mouse
regulation of phosphorus metabolic process	GO:0051174	43	0.024	Human Mouse
erk1 and erk2 cascade	GO:0070371	4	0.024	Human Mouse
response to lipopolysaccharide	GO:0032496	13	0.024	Human
cell type specific apoptotic process	GO:0097285	22	0.023
regulation of vesicle mediated transport	GO:0060627	9	0.023	Mouse
angiogenesis	GO:0001525	158	0.023
cellular component biogenesis	GO:0044085	178	0.023	Mouse
cellular component disassembly	GO:0022411	1	0.023
regulation of nucleic acid templated transcription	GO:1903506	213	0.023	Human
autophagy	GO:0006914	4	0.023	Mouse
regulation of striated muscle contraction	GO:0006942	2	0.023
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	4	0.022
organic anion transport	GO:0015711	15	0.022
heart morphogenesis	GO:0003007	156	0.022
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	1	0.022
negative regulation of blood vessel endothelial cell migration	GO:0043537	1	0.022
negative regulation of endothelial cell migration	GO:0010596	1	0.022
regulation of biosynthetic process	GO:0009889	250	0.022	Human
muscle fiber development	GO:0048747	52	0.021
cellular localization	GO:0051641	97	0.021	Human Mouse
response to inorganic substance	GO:0010035	38	0.021
cell activation	GO:0001775	16	0.021	Human Mouse
protein targeting to nucleus	GO:0044744	3	0.021
cellular amino acid metabolic process	GO:0006520	7	0.021
positive regulation of myeloid cell differentiation	GO:0045639	2	0.021
cytoplasmic pattern recognition receptor signaling pathway	GO:0002753	1	0.021
vesicle mediated transport	GO:0016192	22	0.021	Mouse
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.021
positive regulation of response to stimulus	GO:0048584	80	0.021	Human Mouse
gtp metabolic process	GO:0046039	4	0.020	Mouse
positive regulation of cell adhesion	GO:0045785	1	0.020
response to xenobiotic stimulus	GO:0009410	45	0.020
guanosine containing compound metabolic process	GO:1901068	4	0.020	Mouse
positive regulation of hydrolase activity	GO:0051345	13	0.020
phosphorylation	GO:0016310	69	0.020	Human Mouse
protein localization to plasma membrane	GO:0072659	1	0.020
positive regulation of immune system process	GO:0002684	17	0.020	Human Mouse
cranial nerve development	GO:0021545	42	0.020
reproduction	GO:0000003	40	0.019
regulation of localization	GO:0032879	104	0.019	Human Mouse
multicellular organism reproduction	GO:0032504	35	0.019
response to alkaloid	GO:0043279	2	0.019
determination of left right symmetry	GO:0007368	179	0.019
eye development	GO:0001654	277	0.019
gamete generation	GO:0007276	33	0.019
protein import	GO:0017038	3	0.019
regulation of cellular biosynthetic process	GO:0031326	245	0.019	Human
response to endogenous stimulus	GO:0009719	83	0.019
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.019
regulation of rho protein signal transduction	GO:0035023	2	0.018	Mouse
regulation of nucleoside metabolic process	GO:0009118	2	0.018	Mouse
macromolecule localization	GO:0033036	54	0.018	Human Mouse
negative regulation of multicellular organismal process	GO:0051241	69	0.018	Human
response to mechanical stimulus	GO:0009612	24	0.018
cellular response to stress	GO:0033554	62	0.018	Human
cellular response to starvation	GO:0009267	1	0.018
regulation of cell differentiation	GO:0045595	142	0.018
leukocyte activation	GO:0045321	12	0.018	Human Mouse
multi organism process	GO:0051704	134	0.017	Human Mouse
positive regulation of protein polymerization	GO:0032273	2	0.017	Mouse
developmental growth	GO:0048589	166	0.017
negative regulation of signal transduction	GO:0009968	94	0.017	Human
wound healing	GO:0042060	90	0.017
peripheral nervous system development	GO:0007422	55	0.017
positive regulation of signaling	GO:0023056	56	0.017	Human Mouse
immune effector process	GO:0002252	23	0.017	Human Mouse
protein localization to membrane	GO:0072657	9	0.017
negative regulation of defense response	GO:0031348	2	0.017
neutrophil homeostasis	GO:0001780	1	0.017
establishment of protein localization	GO:0045184	14	0.017	Human Mouse
peripheral nervous system neuron development	GO:0048935	22	0.017
response to glucocorticoid	GO:0051384	1	0.017
neuroblast fate commitment	GO:0014017	1	0.017
phosphorus metabolic process	GO:0006793	109	0.017	Human Mouse
cellular macromolecule biosynthetic process	GO:0034645	224	0.017	Human
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	1	0.017	Human
transcription dna templated	GO:0006351	181	0.017	Human
regulation of protein complex disassembly	GO:0043244	1	0.017
negative regulation of cell death	GO:0060548	60	0.016
positive regulation of glial cell differentiation	GO:0045687	1	0.016
mapk cascade	GO:0000165	18	0.016	Human Mouse
regulation of binding	GO:0051098	3	0.016
negative regulation of cellular process	GO:0048523	283	0.016	Human
folic acid containing compound metabolic process	GO:0006760	2	0.016
positive regulation of dna metabolic process	GO:0051054	1	0.016
keratinocyte differentiation	GO:0030216	0	0.016
digestive tract morphogenesis	GO:0048546	231	0.016
positive regulation of production of molecular mediator of immune response	GO:0002702	1	0.016
cellular component assembly	GO:0022607	170	0.016	Mouse
phosphate containing compound metabolic process	GO:0006796	108	0.016	Human Mouse
lymphocyte proliferation	GO:0046651	1	0.015	Mouse
sensory perception of chemical stimulus	GO:0007606	3	0.015
neuroblast differentiation	GO:0014016	1	0.015
carboxylic acid metabolic process	GO:0019752	22	0.015
myotube differentiation	GO:0014902	45	0.015
regulation of protein localization to nucleus	GO:1900180	2	0.015
positive regulation of jnk cascade	GO:0046330	3	0.015	Human
morphogenesis of an epithelium	GO:0002009	333	0.015
regulation of circadian sleep wake cycle sleep	GO:0045187	1	0.015
cellular aromatic compound metabolic process	GO:0006725	295	0.015	Human Mouse
multicellular organismal reproductive process	GO:0048609	35	0.015
nuclear import	GO:0051170	3	0.015
macromolecule biosynthetic process	GO:0009059	227	0.015	Human
negative regulation of kinase activity	GO:0033673	4	0.014	Human
positive regulation of cell activation	GO:0050867	1	0.014	Human Mouse
glycoprotein biosynthetic process	GO:0009101	21	0.014
reactive oxygen species metabolic process	GO:0072593	6	0.014
chemical homeostasis	GO:0048878	49	0.014
negative regulation of programmed cell death	GO:0043069	58	0.014
regulation of oligodendrocyte differentiation	GO:0048713	1	0.014
hemopoiesis	GO:0030097	183	0.014
protein localization to nucleus	GO:0034504	3	0.014
meiotic nuclear division	GO:0007126	4	0.014
head development	GO:0060322	303	0.014
endocardial cushion formation	GO:0003272	2	0.014
regulation of phosphate metabolic process	GO:0019220	43	0.014	Human Mouse
response to cytokine	GO:0034097	7	0.014	Human
positive regulation of intracellular signal transduction	GO:1902533	15	0.013	Human Mouse
small molecule metabolic process	GO:0044281	77	0.013	Mouse
nucleic acid metabolic process	GO:0090304	244	0.013	Human
negative regulation of signaling	GO:0023057	96	0.013	Human
positive regulation of epithelial cell proliferation	GO:0050679	1	0.013
negative regulation of protein transport	GO:0051224	3	0.013
negative regulation of biological process	GO:0048519	304	0.013	Human
behavior	GO:0007610	74	0.013
anion transport	GO:0006820	38	0.013
regulation of heart contraction	GO:0008016	32	0.013
pole plasm assembly	GO:0007315	4	0.013
response to organic substance	GO:0010033	153	0.013	Human
regulation of protein complex assembly	GO:0043254	3	0.013	Mouse
localization of cell	GO:0051674	244	0.013	Mouse
neuron projection morphogenesis	GO:0048812	161	0.013
phosphatidylinositol mediated signaling	GO:0048015	2	0.012
regulation of ph	GO:0006885	3	0.012
growth	GO:0040007	174	0.012
b cell activation	GO:0042113	2	0.012
positive regulation of gtp catabolic process	GO:0033126	1	0.012
cellular response to organic cyclic compound	GO:0071407	38	0.012
nucleobase containing compound metabolic process	GO:0006139	274	0.012	Human Mouse
response to uv	GO:0009411	3	0.012
membrane organization	GO:0061024	21	0.012
regulation of cellular ph	GO:0030641	1	0.012
regulation of immune response	GO:0050776	14	0.012	Human Mouse
one carbon compound transport	GO:0019755	14	0.011
positive regulation of biosynthetic process	GO:0009891	68	0.011
single organism cellular localization	GO:1902580	46	0.011
protein import into nucleus	GO:0006606	3	0.011
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.011
response to alcohol	GO:0097305	14	0.011
positive regulation of stem cell proliferation	GO:2000648	1	0.011
regulation of dna replication	GO:0006275	3	0.011
cellular response to hormone stimulus	GO:0032870	39	0.011
spermatid differentiation	GO:0048515	2	0.011
regulation of coagulation	GO:0050818	2	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.011
mitotic cell cycle	GO:0000278	64	0.011
negative regulation of apoptotic process	GO:0043066	55	0.011
adherens junction organization	GO:0034332	4	0.011
epidermal cell differentiation	GO:0009913	36	0.011
g1 s transition of mitotic cell cycle	GO:0000082	1	0.011
positive regulation of gtpase activity	GO:0043547	1	0.011
nucleobase containing small molecule metabolic process	GO:0055086	32	0.011	Mouse
regulation of protein targeting	GO:1903533	2	0.011
ion transport	GO:0006811	114	0.011
rna biosynthetic process	GO:0032774	181	0.011	Human
regulation of gtpase activity	GO:0043087	2	0.011	Mouse
epithelial tube morphogenesis	GO:0060562	148	0.011
protein localization	GO:0008104	40	0.011	Human Mouse
regulation of cell cycle process	GO:0010564	20	0.011
cellular response to extracellular stimulus	GO:0031668	2	0.011
protein polymerization	GO:0051258	4	0.011	Mouse
organonitrogen compound biosynthetic process	GO:1901566	47	0.011
macromolecular complex subunit organization	GO:0043933	74	0.011	Mouse
pteridine containing compound metabolic process	GO:0042558	3	0.011
protein depolymerization	GO:0051261	1	0.011
regulation of transport	GO:0051049	45	0.010	Human Mouse
regulation of dna templated transcription in response to stress	GO:0043620	0	0.010
mononuclear cell proliferation	GO:0032943	1	0.010	Mouse
gtp catabolic process	GO:0006184	2	0.010	Mouse
immune system development	GO:0002520	191	0.010
atrioventricular valve development	GO:0003171	11	0.010
organelle fusion	GO:0048284	3	0.010
positive regulation of cellular component organization	GO:0051130	13	0.010	Human Mouse
cell projection organization	GO:0030030	284	0.010
negative regulation of epithelial cell migration	GO:0010633	1	0.010
regulation of leukocyte mediated immunity	GO:0002703	1	0.010
neurological system process	GO:0050877	62	0.010
blood circulation	GO:0008015	87	0.010
regulation of muscle hypertrophy	GO:0014743	2	0.010
muscle cell differentiation	GO:0042692	139	0.010
cellular response to oxygen levels	GO:0071453	1	0.010
regulation of transferase activity	GO:0051338	16	0.010	Human

pycard disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.025
disease of metabolism	DOID:0014667	0.017
musculoskeletal system disease	DOID:17	0.013
amyloidosis	DOID:9120	0.012
acquired metabolic disease	DOID:0060158	0.012
integumentary system disease	DOID:16	0.010

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