IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

rabgef1l

RAB guanine nucleotide exchange factor (GEF) 1, like

(Aliases: zgc:55834,MGC55834,rabgef1)

Ensembl: ENSDARG00000015968
ZFIN: ZDB-GENE-040426-813
Entrez: 393915
UniProtKB: Q7ZVP0

Process Predictions
Disease Predictions

rabgef1l biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
camera type eye development	GO:0043010	222	0.223
eye development	GO:0001654	277	0.200
central nervous system development	GO:0007417	387	0.198
eye morphogenesis	GO:0048592	144	0.189
cellular macromolecule metabolic process	GO:0044260	391	0.171	Mouse
brain development	GO:0007420	293	0.155
sensory organ morphogenesis	GO:0090596	200	0.145
sleep	GO:0030431	1	0.141
cellular aromatic compound metabolic process	GO:0006725	295	0.107
head development	GO:0060322	303	0.106
regulation of primary metabolic process	GO:0080090	311	0.103	Mouse
camera type eye morphogenesis	GO:0048593	108	0.096
generation of neurons	GO:0048699	385	0.085
sensory organ development	GO:0007423	393	0.084
gland development	GO:0048732	143	0.082
regulation of rna metabolic process	GO:0051252	224	0.081
nitrogen compound metabolic process	GO:0006807	319	0.079
gene expression	GO:0010467	252	0.078
immune system development	GO:0002520	191	0.078
digestive system development	GO:0055123	289	0.069
regulation of cellular metabolic process	GO:0031323	320	0.065	Mouse
heterocycle metabolic process	GO:0046483	290	0.064
macromolecule biosynthetic process	GO:0009059	227	0.063
aromatic compound biosynthetic process	GO:0019438	217	0.063
aging	GO:0007568	2	0.062
circadian sleep wake cycle sleep	GO:0050802	1	0.062
heart development	GO:0007507	313	0.060
cell morphogenesis	GO:0000902	289	0.060
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.059
larval development	GO:0002164	2	0.059
circadian sleep wake cycle	GO:0042745	2	0.059
retina morphogenesis in camera type eye	GO:0060042	79	0.056
centrosome organization	GO:0051297	1	0.056
nucleic acid metabolic process	GO:0090304	244	0.055
regulation of nitrogen compound metabolic process	GO:0051171	251	0.055
vasculature development	GO:0001944	278	0.055
cognition	GO:0050890	1	0.052
organic substance biosynthetic process	GO:1901576	289	0.052
regulation of anatomical structure morphogenesis	GO:0022603	130	0.049
cell projection organization	GO:0030030	284	0.048
developmental growth	GO:0048589	166	0.048
biosynthetic process	GO:0009058	294	0.048
microtubule organizing center organization	GO:0031023	1	0.048
embryo development ending in birth or egg hatching	GO:0009792	271	0.048
retina development in camera type eye	GO:0060041	146	0.047
axon extension	GO:0048675	45	0.047
energy reserve metabolic process	GO:0006112	2	0.047
regulation of mrna splicing via spliceosome	GO:0048024	3	0.046
regulation of microtubule cytoskeleton organization	GO:0070507	3	0.045
neuron differentiation	GO:0030182	353	0.044
cellular biosynthetic process	GO:0044249	286	0.044
ubiquitin dependent protein catabolic process	GO:0006511	3	0.044
centrosome duplication	GO:0051298	1	0.043
regulation of cellular biosynthetic process	GO:0031326	245	0.041
hematopoietic or lymphoid organ development	GO:0048534	191	0.040
regulation of developmental process	GO:0050793	247	0.039
negative regulation of biological process	GO:0048519	304	0.039	Mouse
heterocycle biosynthetic process	GO:0018130	215	0.038
regulation of organ growth	GO:0046620	3	0.038
organic cyclic compound metabolic process	GO:1901360	301	0.037
endocrine system development	GO:0035270	65	0.037
neuron development	GO:0048666	262	0.035
regulation of gene expression	GO:0010468	265	0.035
cellular component morphogenesis	GO:0032989	336	0.034
circadian sleep wake cycle process	GO:0022410	2	0.034
embryonic eye morphogenesis	GO:0048048	30	0.034
positive regulation of cellular catabolic process	GO:0031331	3	0.034
morphogenesis of an epithelium	GO:0002009	333	0.033
regulation of circadian rhythm	GO:0042752	4	0.033
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.033
pancreas development	GO:0031016	84	0.033
negative regulation of cellular process	GO:0048523	283	0.033	Mouse
alternative mrna splicing via spliceosome	GO:0000380	1	0.033
positive regulation of cell cycle	GO:0045787	3	0.032
neuron projection extension	GO:1990138	45	0.032
axonogenesis	GO:0007409	152	0.032
rna biosynthetic process	GO:0032774	181	0.032
axon development	GO:0061564	166	0.031
modification dependent protein catabolic process	GO:0019941	3	0.031
neuron projection morphogenesis	GO:0048812	161	0.031
positive regulation of biological process	GO:0048518	253	0.031	Mouse
embryonic organ morphogenesis	GO:0048562	274	0.031
cellular nitrogen compound metabolic process	GO:0034641	290	0.031
female sex differentiation	GO:0046660	4	0.031
tube morphogenesis	GO:0035239	349	0.031
cell projection morphogenesis	GO:0048858	244	0.030
hemopoiesis	GO:0030097	183	0.030
regulation of transcription dna templated	GO:0006355	213	0.030
developmental growth involved in morphogenesis	GO:0060560	86	0.030
digestive tract development	GO:0048565	265	0.029
response to chemical	GO:0042221	320	0.029	Mouse
neural retina development	GO:0003407	49	0.029
regulation of meiotic cell cycle	GO:0051445	1	0.029
proteasomal protein catabolic process	GO:0010498	2	0.029
embryonic camera type eye development	GO:0031076	29	0.029
positive regulation of cell division	GO:0051781	2	0.028
negative regulation of protein phosphorylation	GO:0001933	4	0.028	Mouse
maintenance of location	GO:0051235	4	0.027
synaptic transmission cholinergic	GO:0007271	4	0.027
nucleobase containing compound metabolic process	GO:0006139	274	0.027
regionalization	GO:0003002	274	0.027
response to stress	GO:0006950	263	0.027	Mouse
cellular protein catabolic process	GO:0044257	4	0.027
signal transduction	GO:0007165	455	0.026	Mouse
centrosome cycle	GO:0007098	1	0.026
phagocytosis	GO:0006909	3	0.026
regulation of circadian sleep wake cycle sleep	GO:0045187	1	0.025
stem cell maintenance	GO:0019827	4	0.025
single organism localization	GO:1902578	225	0.025	Mouse
cell motility	GO:0048870	244	0.025	Mouse
cell morphogenesis involved in differentiation	GO:0000904	195	0.024
cell migration	GO:0016477	237	0.024	Mouse
digestive tract morphogenesis	GO:0048546	231	0.024
neuron projection development	GO:0031175	180	0.024
embryonic skeletal system development	GO:0048706	97	0.024
guanosine containing compound metabolic process	GO:1901068	4	0.024
regulation of macromolecule metabolic process	GO:0060255	317	0.024	Mouse
negative regulation of cell differentiation	GO:0045596	46	0.024
regulation of stem cell differentiation	GO:2000736	4	0.024
positive regulation of dna metabolic process	GO:0051054	1	0.023
positive regulation of catabolic process	GO:0009896	4	0.023
spermatid differentiation	GO:0048515	2	0.023
regeneration	GO:0031099	91	0.023
cell surface receptor signaling pathway	GO:0007166	325	0.023	Mouse
regulation of biosynthetic process	GO:0009889	250	0.023
system process	GO:0003008	185	0.022
response to topologically incorrect protein	GO:0035966	2	0.022
regulation of multicellular organismal development	GO:2000026	223	0.022
neuron projection guidance	GO:0097485	86	0.022
transcription dna templated	GO:0006351	181	0.022
heart contraction	GO:0060047	71	0.022
adult behavior	GO:0030534	2	0.022
axon guidance	GO:0007411	86	0.022
cell part morphogenesis	GO:0032990	246	0.021
regulation of metabolic process	GO:0019222	359	0.021	Mouse
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.021
gastrulation	GO:0007369	208	0.021
regulation of biological quality	GO:0065008	263	0.021
multicellular organism growth	GO:0035264	4	0.021
cellular response to extracellular stimulus	GO:0031668	2	0.021
regulation of rna biosynthetic process	GO:2001141	213	0.021
homeostatic process	GO:0042592	142	0.021
rna metabolic process	GO:0016070	219	0.021
hepaticobiliary system development	GO:0061008	98	0.020
modification dependent macromolecule catabolic process	GO:0043632	3	0.020
growth	GO:0040007	174	0.020
cellular response to nutrient levels	GO:0031669	2	0.020
lipid storage	GO:0019915	1	0.020
regulation of circadian sleep wake cycle	GO:0042749	1	0.020
blood vessel development	GO:0001568	246	0.019
negative regulation of catabolic process	GO:0009895	3	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.019
embryonic organ development	GO:0048568	381	0.019
negative regulation of metabolic process	GO:0009892	86	0.019	Mouse
regulation of cell communication	GO:0010646	232	0.018	Mouse
blood vessel morphogenesis	GO:0048514	216	0.018
negative regulation of cellular catabolic process	GO:0031330	3	0.018
positive regulation of notch signaling pathway	GO:0045747	3	0.018
cellular response to organic substance	GO:0071310	105	0.018	Mouse
cellular response to topologically incorrect protein	GO:0035967	2	0.018
embryonic skeletal system morphogenesis	GO:0048704	93	0.018
regulation of reproductive process	GO:2000241	4	0.018
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.018
spemann organizer formation at the embryonic shield	GO:0060063	2	0.018
cartilage development	GO:0051216	96	0.017
neuron remodeling	GO:0016322	1	0.017
embryonic limb morphogenesis	GO:0030326	2	0.017
regulation of nervous system development	GO:0051960	90	0.017
embryonic heart tube development	GO:0035050	133	0.017
retinal ganglion cell axon guidance	GO:0031290	35	0.017
stem cell division	GO:0017145	1	0.017
regulation of signal transduction	GO:0009966	225	0.017	Mouse
skeletal system development	GO:0001501	181	0.017
gtp metabolic process	GO:0046039	4	0.017
protein localization to nucleus	GO:0034504	3	0.017
cardiac cell fate commitment	GO:0060911	1	0.017
organic cyclic compound biosynthetic process	GO:1901362	223	0.017
ear development	GO:0043583	127	0.017
regulation of nucleic acid templated transcription	GO:1903506	213	0.016
convergent extension	GO:0060026	118	0.016
chordate embryonic development	GO:0043009	271	0.016
peripheral nervous system neuron differentiation	GO:0048934	28	0.016
appendage development	GO:0048736	80	0.016
negative regulation of stem cell differentiation	GO:2000737	2	0.016
positive regulation of transport	GO:0051050	2	0.016
positive regulation of muscle organ development	GO:0048636	1	0.016
positive regulation of cellular biosynthetic process	GO:0031328	68	0.016
cell proliferation	GO:0008283	80	0.016
wound healing	GO:0042060	90	0.016
single organism metabolic process	GO:0044710	217	0.016
exocrine pancreas development	GO:0031017	28	0.016
locomotion	GO:0040011	313	0.016	Mouse
photoreceptor cell differentiation	GO:0046530	55	0.016
intracellular receptor signaling pathway	GO:0030522	30	0.015
hormone transport	GO:0009914	2	0.015
developmental cell growth	GO:0048588	52	0.015
regulation of cytoplasmic transport	GO:1903649	4	0.015
regulation of cellular component movement	GO:0051270	55	0.015	Mouse
cellular response to starvation	GO:0009267	1	0.015
response to wounding	GO:0009611	116	0.015	Mouse
anterior posterior pattern specification	GO:0009952	152	0.015
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.015
cellular component movement	GO:0006928	335	0.015	Mouse
positive regulation of cell communication	GO:0010647	56	0.015
skeletal system morphogenesis	GO:0048705	102	0.015
eye photoreceptor cell differentiation	GO:0001754	45	0.015
stem cell differentiation	GO:0048863	117	0.015
spermatid development	GO:0007286	2	0.015
forebrain development	GO:0030900	96	0.015
hormone secretion	GO:0046879	2	0.015
guanosine containing compound catabolic process	GO:1901069	2	0.014
behavior	GO:0007610	74	0.014
single organism cellular localization	GO:1902580	46	0.014	Mouse
determination of bilateral symmetry	GO:0009855	204	0.014
regulation of signaling	GO:0023051	235	0.014	Mouse
protein heterooligomerization	GO:0051291	1	0.014
regulation of cell shape	GO:0008360	1	0.014
oxoacid metabolic process	GO:0043436	31	0.014
protein complex subunit organization	GO:0071822	46	0.014
protein acetylation	GO:0006473	2	0.014
myotube differentiation	GO:0014902	45	0.014
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.014
nuclear transport	GO:0051169	4	0.014
positive regulation of jnk cascade	GO:0046330	3	0.014
fin development	GO:0033333	77	0.014
branching morphogenesis of a nerve	GO:0048755	4	0.014
negative regulation of mrna processing	GO:0050686	1	0.014
regulation of neurogenesis	GO:0050767	87	0.014
endocrine pancreas development	GO:0031018	27	0.014
nucleic acid templated transcription	GO:0097659	181	0.014
cellular response to chemical stimulus	GO:0070887	157	0.014	Mouse
somite development	GO:0061053	96	0.013
cellular response to growth factor stimulus	GO:0071363	39	0.013
regulation of neuron differentiation	GO:0045664	56	0.013
cell fate commitment	GO:0045165	99	0.013
segmentation	GO:0035282	97	0.013
stem cell proliferation	GO:0072089	4	0.013
alpha amino acid metabolic process	GO:1901605	3	0.013
negative regulation of protein kinase activity	GO:0006469	4	0.013
response to estrogen	GO:0043627	27	0.013
nucleocytoplasmic transport	GO:0006913	4	0.013
epiboly	GO:0090504	41	0.013
internal protein amino acid acetylation	GO:0006475	2	0.013
negative regulation of kinase activity	GO:0033673	4	0.013
cellular response to external stimulus	GO:0071496	2	0.013
regulation of macromolecule biosynthetic process	GO:0010556	225	0.013
regulation of establishment of protein localization	GO:0070201	4	0.013	Mouse
positive regulation of signal transduction	GO:0009967	56	0.013
mesenchyme development	GO:0060485	127	0.013
positive regulation of gene expression	GO:0010628	71	0.013
positive regulation of signaling	GO:0023056	56	0.013
protein import into nucleus	GO:0006606	3	0.013
mitotic cell cycle process	GO:1903047	48	0.013
tissue remodeling	GO:0048771	4	0.013
peripheral nervous system neuron development	GO:0048935	22	0.013
cell cycle g1 s phase transition	GO:0044843	1	0.013
localization of cell	GO:0051674	244	0.013	Mouse
negative regulation of ras protein signal transduction	GO:0046580	1	0.012	Mouse
gtp catabolic process	GO:0006184	2	0.012
internal peptidyl lysine acetylation	GO:0018393	2	0.012
regulation of alternative mrna splicing via spliceosome	GO:0000381	1	0.012
negative regulation of macromolecule metabolic process	GO:0010605	76	0.012	Mouse
membrane lipid biosynthetic process	GO:0046467	2	0.012
neurotransmitter transport	GO:0006836	2	0.012
small molecule metabolic process	GO:0044281	77	0.012
pharyngeal muscle development	GO:0043282	4	0.012
regulation of cytokine production	GO:0001817	3	0.012	Mouse
odontogenesis of dentin containing tooth	GO:0042475	1	0.012
regulation of nucleocytoplasmic transport	GO:0046822	2	0.012
tissue regeneration	GO:0042246	74	0.012
regulation of blood pressure	GO:0008217	1	0.012
cytoskeleton dependent cytokinesis	GO:0061640	3	0.012
cellular amino acid metabolic process	GO:0006520	7	0.012
regulation of protein catabolic process	GO:0042176	1	0.012
activation of mapk activity	GO:0000187	3	0.012
cellular amine metabolic process	GO:0044106	2	0.012
cortical cytoskeleton organization	GO:0030865	1	0.012
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.011
positive regulation of metabolic process	GO:0009893	108	0.011
protein targeting to nucleus	GO:0044744	3	0.011
positive regulation of map kinase activity	GO:0043406	3	0.011
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.011
positive regulation of cellular component biogenesis	GO:0044089	3	0.011
regulation of synaptic plasticity	GO:0048167	1	0.011
response to glucose	GO:0009749	3	0.011
multi organism cellular process	GO:0044764	2	0.011
establishment of localization	GO:0051234	244	0.011	Mouse
mesenchymal cell differentiation	GO:0048762	87	0.011
negative regulation of developmental process	GO:0051093	65	0.011
cellular response to unfolded protein	GO:0034620	2	0.011
positive regulation of jun kinase activity	GO:0043507	2	0.011
cellular localization	GO:0051641	97	0.011	Mouse
regulation of neurotransmitter transport	GO:0051588	1	0.011
carbohydrate homeostasis	GO:0033500	1	0.011
cellular macromolecule biosynthetic process	GO:0034645	224	0.011
apoptotic process	GO:0006915	116	0.011
positive regulation of biosynthetic process	GO:0009891	68	0.011
organonitrogen compound metabolic process	GO:1901564	74	0.011
regulation of protein transport	GO:0051223	3	0.011	Mouse
fin regeneration	GO:0031101	51	0.011
regulation of multicellular organismal process	GO:0051239	277	0.011	Mouse
cell aging	GO:0007569	2	0.011
carboxylic acid metabolic process	GO:0019752	22	0.011
nephron tubule morphogenesis	GO:0072078	1	0.011
muscle cell differentiation	GO:0042692	139	0.011
positive regulation of striated muscle tissue development	GO:0045844	1	0.010
cell death	GO:0008219	121	0.010
post embryonic organ development	GO:0048569	4	0.010
cell cell signaling	GO:0007267	52	0.010
central nervous system neuron differentiation	GO:0021953	74	0.010
multicellular organismal response to stress	GO:0033555	2	0.010
protein import	GO:0017038	3	0.010
response to hydrogen peroxide	GO:0042542	3	0.010
nucleobase containing compound biosynthetic process	GO:0034654	205	0.010
development of primary female sexual characteristics	GO:0046545	4	0.010
regulation of gastrulation	GO:0010470	24	0.010
single organism transport	GO:0044765	206	0.010	Mouse
somatic stem cell maintenance	GO:0035019	1	0.010
angiogenesis	GO:0001525	158	0.010
regulation of response to stimulus	GO:0048583	269	0.010	Mouse

rabgef1l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.016
disease of anatomical entity	DOID:7	0.016
disease of cellular proliferation	DOID:14566	0.011

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network