Danio rerio

0 known processes

ppp2r5ea

protein phosphatase 2, regulatory subunit B', epsilon isoform a

(Aliases: ppp2r5e2,zgc:85613,MGC85613,wdb1)

ppp2r5ea biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein targeting to nucleusGO:004474430.285
regulation of primary metabolic processGO:00800903110.175
positive regulation of transportGO:005105020.163
establishment of protein localization to organelleGO:007259440.156
cognitionGO:005089010.148
cellular macromolecule metabolic processGO:00442603910.142
single organism localizationGO:19025782250.136
nuclear transportGO:005116940.134
signal transductionGO:00071654550.133
regulation of metabolic processGO:00192223590.122
protein localization to nucleusGO:003450430.118
protein import into nucleusGO:000660630.116
larval developmentGO:000216420.115
proteolysis involved in cellular protein catabolic processGO:005160330.107
single organism transportGO:00447652060.107
positive regulation of biological processGO:00485182530.102
protein metabolic processGO:00195381830.102
positive regulation of lymphocyte mediated immunityGO:000270810.095
phagocytosisGO:000690930.092
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.089
macromolecule biosynthetic processGO:00090592270.087
negative regulation of ras protein signal transductionGO:004658010.087
regulation of protein localization to nucleusGO:190018020.086
nuclear importGO:005117030.085
establishment of localizationGO:00512342440.082
single organism nuclear importGO:190259330.082
regulation of protein import into nucleusGO:004230620.080
negative regulation of biological processGO:00485193040.080
rna metabolic processGO:00160702190.079
negative regulation of protein transportGO:005122430.079
cell surface receptor signaling pathwayGO:00071663250.078
cellular aromatic compound metabolic processGO:00067252950.076
regulation of protein targetingGO:190353320.076
regulation of protein transportGO:005122330.075
organic cyclic compound metabolic processGO:19013603010.074
golgi vesicle transportGO:004819330.073
protein importGO:001703830.073
response to chemicalGO:00422213200.072
small gtpase mediated signal transductionGO:000726480.070
regionalizationGO:00030022740.070
regulation of establishment of protein localizationGO:007020140.068
regulation of signalingGO:00230512350.067
neuron differentiationGO:00301823530.066
agingGO:000756820.064
Fly
regulation of cell communicationGO:00106462320.063
regulation of response to stimulusGO:00485832690.063
negative regulation of cellular processGO:00485232830.062
single organism cellular localizationGO:1902580460.061
regulation of cellular biosynthetic processGO:00313262450.061
modification dependent protein catabolic processGO:001994130.059
ubiquitin dependent protein catabolic processGO:000651130.059
regulation of protein catabolic processGO:004217610.059
gene expressionGO:00104672520.059
cellular protein metabolic processGO:00442671290.058
chordate embryonic developmentGO:00430092710.058
nucleocytoplasmic transportGO:000691340.058
positive regulation of cell cycleGO:004578730.057
regulation of nucleocytoplasmic transportGO:004682220.057
cellular protein catabolic processGO:004425740.057
gtp metabolic processGO:004603940.057
spindle assemblyGO:005122520.057
Fly
vacuolar transportGO:000703420.056
regulation of macromolecule metabolic processGO:00602553170.056
regulation of signal transductionGO:00099662250.056
regulation of nucleic acid templated transcriptionGO:19035062130.055
positive regulation of cellular processGO:00485222010.055
post golgi vesicle mediated transportGO:000689210.055
embryo development ending in birth or egg hatchingGO:00097922710.052
ras protein signal transductionGO:000726570.052
negative regulation of cytoplasmic transportGO:190365020.051
regulation of gene expressionGO:00104682650.051
negative regulation of intracellular transportGO:003238730.051
immune system processGO:00023762410.051
response to stressGO:00069502630.051
nucleobase containing compound biosynthetic processGO:00346542050.050
centrosome cycleGO:000709810.049
protein secretionGO:000930610.049
negative regulation of nucleocytoplasmic transportGO:004682320.049
positive regulation of secretionGO:005104710.049
transportGO:00068102200.049
positive regulation of cellular catabolic processGO:003133130.048
regulation of natural killer cell mediated immunityGO:000271510.048
response to organic substanceGO:00100331530.048
gtp catabolic processGO:000618420.048
negative regulation of protein phosphorylationGO:000193340.047
cellular macromolecule biosynthetic processGO:00346452240.047
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.047
aromatic compound biosynthetic processGO:00194382170.045
microtubule organizing center organizationGO:003102310.044
endosomal transportGO:001619720.044
cellular nitrogen compound biosynthetic processGO:00442712180.044
positive regulation of map kinase activityGO:004340630.044
regulation of localizationGO:00328791040.044
eye developmentGO:00016542770.044
negative regulation of protein kinase activityGO:000646940.043
amine metabolic processGO:000930820.043
regulation of protein complex assemblyGO:004325430.042
nitrogen compound metabolic processGO:00068073190.042
heterocycle biosynthetic processGO:00181302150.042
cellular biosynthetic processGO:00442492860.042
adult behaviorGO:003053420.042
regulation of protein modification by small protein conjugation or removalGO:190332030.041
positive regulation of response to stimulusGO:0048584800.041
regulation of intracellular protein transportGO:003315730.041
regulation of cellular macromolecule biosynthetic processGO:20001122220.041
meiotic cell cycle processGO:190304630.040
regulation of response to cytokine stimulusGO:006075930.040
positive regulation of catabolic processGO:000989640.040
organic cyclic compound biosynthetic processGO:19013622230.040
negative regulation of catabolic processGO:000989530.040
nucleic acid metabolic processGO:00903042440.040
embryonic organ developmentGO:00485683810.040
cellular component biogenesisGO:00440851780.040
Fly
guanosine containing compound catabolic processGO:190106920.039
rna biosynthetic processGO:00327741810.039
regulation of cellular metabolic processGO:00313233200.039
organic substance biosynthetic processGO:19015762890.039
cellular response to nutrient levelsGO:003166920.038
cellular component movementGO:00069283350.038
macromolecule modificationGO:00434121110.038
negative regulation of metabolic processGO:0009892860.038
multicellular organism growthGO:003526440.037
biosynthetic processGO:00090582940.037
centrosome organizationGO:005129710.037
negative regulation of macromolecule metabolic processGO:0010605760.037
cellular amine metabolic processGO:004410620.037
regulation of rna metabolic processGO:00512522240.037
positive regulation of i kappab kinase nf kappab signalingGO:004312330.037
regulation of transcription dna templatedGO:00063552130.037
protein dephosphorylationGO:000647030.036
positive regulation of immune effector processGO:000269930.036
transcription dna templatedGO:00063511810.036
response to external biotic stimulusGO:0043207970.036
cellular component morphogenesisGO:00329893360.036
regulation of nucleobase containing compound metabolic processGO:00192192500.036
regulation of cell killingGO:003134120.036
cell motilityGO:00488702440.036
negative regulation of kinase activityGO:003367340.036
cellular nitrogen compound metabolic processGO:00346412900.035
extrinsic apoptotic signaling pathwayGO:009719130.035
positive regulation of secretion by cellGO:190353210.035
small molecule metabolic processGO:0044281770.035
lysosomal transportGO:000704120.035
cellular amino acid metabolic processGO:000652070.035
system processGO:00030081850.035
exocytosisGO:000688710.034
mitotic dna integrity checkpointGO:004477440.034
regulation of circadian rhythmGO:004275240.034
regulation of cytoplasmic transportGO:190364940.033
regulation of cellular amino acid metabolic processGO:000652100.033
cellular ketone metabolic processGO:0042180110.033
negative regulation of signalingGO:0023057960.033
cellular response to external stimulusGO:007149620.033
positive regulation of stress activated mapk cascadeGO:003287430.033
positive regulation of cell killingGO:003134320.033
negative regulation of protein localization to nucleusGO:190018120.033
cell deathGO:00082191210.032
mitotic g2 m transition checkpointGO:004481830.032
regulation of peptidyl tyrosine phosphorylationGO:005073010.032
nucleobase containing compound metabolic processGO:00061392740.032
positive regulation of wound healingGO:009030310.032
locomotor rhythmGO:004547530.032
meiotic nuclear divisionGO:000712640.032
regulation of nucleoside metabolic processGO:000911820.032
phagocytosis engulfmentGO:000691110.031
regulation of cellular carbohydrate metabolic processGO:001067540.031
cell morphogenesis involved in differentiationGO:00009041950.031
single fertilizationGO:000733830.031
guanosine containing compound metabolic processGO:190106840.031
pectoral fin developmentGO:0033339500.031
single organism metabolic processGO:00447102170.030
regulation of cellular amine metabolic processGO:003323800.030
regulation of nitrogen compound metabolic processGO:00511712510.030
phosphate containing compound metabolic processGO:00067961080.030
skeletal system developmentGO:00015011810.030
positive regulation of gtpase activityGO:004354710.030
organonitrogen compound metabolic processGO:1901564740.030
cellular carbohydrate metabolic processGO:004426240.030
leukocyte mediated cytotoxicityGO:000190910.030
regulation of gtp catabolic processGO:003312420.030
i kappab kinase nf kappab signalingGO:000724940.030
immune responseGO:0006955280.030
proteasomal protein catabolic processGO:001049820.030
regulation of developmental processGO:00507932470.030
positive regulation of purine nucleotide catabolic processGO:003312310.030
regulation of macromolecule biosynthetic processGO:00105562250.029
organelle assemblyGO:00709251100.029
Fly
negative regulation of protein import into nucleusGO:004230820.029
maintenance of locationGO:005123540.029
regulation of multicellular organism growthGO:004001440.029
regulation of purine nucleotide catabolic processGO:003312120.029
regulation of cell activationGO:005086510.029
response to drugGO:004249330.029
positive regulation of cellular component biogenesisGO:004408930.029
cell migrationGO:00164772370.028
regulation of cellular ketone metabolic processGO:001056570.028
regulation of stem cell differentiationGO:200073640.028
organic acid metabolic processGO:0006082310.028
sensory organ developmentGO:00074233930.028
positive regulation of leukocyte mediated cytotoxicityGO:000191210.028
regulation of nucleotide catabolic processGO:003081120.028
peptide transportGO:001583310.028
generation of neuronsGO:00486993850.028
negative regulation of small gtpase mediated signal transductionGO:005105810.028
cellular response to stressGO:0033554620.028
cell morphogenesis involved in neuron differentiationGO:00486671630.028
cell projection morphogenesisGO:00488582440.028
positive regulation of leukocyte mediated immunityGO:000270510.027
regulation of protein metabolic processGO:0051246560.027
modification dependent macromolecule catabolic processGO:004363230.027
camera type eye developmentGO:00430102220.027
autophagyGO:000691440.027
Fly
negative regulation of nitrogen compound metabolic processGO:0051172590.027
heterocycle metabolic processGO:00464832900.027
erk1 and erk2 cascadeGO:007037140.027
apoptotic processGO:00069151160.027
positive regulation of innate immune responseGO:004508980.026
cell cycleGO:0007049930.026
Fly
cytokinesisGO:000091030.026
membrane fusionGO:006102520.026
regulation of autophagyGO:001050630.026
embryonic organ morphogenesisGO:00485622740.026
positive regulation of nucleoside metabolic processGO:004597910.026
response to external stimulusGO:00096052640.026
neuron projection developmentGO:00311751800.026
regulation of hormone secretionGO:004688320.026
axon developmentGO:00615641660.025
regulation of wound healingGO:006104120.025
negative regulation of map kinase activityGO:004340720.025
regulation of cell developmentGO:00602841000.025
positive regulation of cellular amino acid metabolic processGO:004576400.025
lipid storageGO:001991510.025
carboxylic acid metabolic processGO:0019752220.025
cellular response to organic substanceGO:00713101050.024
positive regulation of protein complex assemblyGO:003133420.024
protein modification processGO:00362111000.024
response to topologically incorrect proteinGO:003596620.024
cellular response to starvationGO:000926710.024
regulation of i kappab kinase nf kappab signalingGO:004312240.024
oxoacid metabolic processGO:0043436310.024
forebrain cell migrationGO:002188510.024
locomotionGO:00400113130.024
stem cell proliferationGO:007208940.024
membrane invaginationGO:001032410.024
cellular response to extracellular stimulusGO:003166820.024
nucleic acid templated transcriptionGO:00976591810.024
negative regulation of cellular catabolic processGO:003133030.024
protein localizationGO:0008104400.024
regulation of leukocyte mediated cytotoxicityGO:000191010.024
regulation of reproductive processGO:200024140.024
protein complex biogenesisGO:0070271300.024
Fly
hormone transportGO:000991420.023
head developmentGO:00603223030.023
neurological system processGO:0050877620.023
negative regulation of protein complex assemblyGO:003133310.023
phosphorylationGO:0016310690.023
positive regulation of metabolic processGO:00098931080.023
actin polymerization or depolymerizationGO:000815420.023
positive regulation of cellular amine metabolic processGO:003324000.023
cellular response to unfolded proteinGO:003462020.023
regulation of protein ubiquitinationGO:003139630.023
intracellular signal transductionGO:0035556850.023
enzyme linked receptor protein signaling pathwayGO:00071671060.023
gland developmentGO:00487321430.023
positive regulation of cell activationGO:005086710.023
brain developmentGO:00074202930.023
programmed cell deathGO:00125011190.023
regulation of dendrite developmentGO:005077330.023
regulation of erk1 and erk2 cascadeGO:007037240.023
regulation of rna biosynthetic processGO:20011412130.022
regulation of catalytic activityGO:0050790550.022
digestive system developmentGO:00551232890.022
muscle structure developmentGO:00610611960.022
regulation of bindingGO:005109830.022
negative regulation of intracellular protein transportGO:009031730.022
organelle organizationGO:00069962270.022
Fly
neuron developmentGO:00486662620.022
immune system developmentGO:00025201910.022
hemopoiesisGO:00300971830.022
positive regulation of nucleotide catabolic processGO:003081310.021
g2 dna damage checkpointGO:003157230.021
developmental growthGO:00485891660.021
regulation of biosynthetic processGO:00098892500.021
negative regulation of protein serine threonine kinase activityGO:007190120.021
cell cycle g1 s phase transitionGO:004484310.021
natural killer cell mediated immunityGO:000222810.021
pigment cell differentiationGO:0050931380.021
deathGO:00162651210.021
positive regulation of erk1 and erk2 cascadeGO:007037420.021
cellular respirationGO:004533330.021
regulation of response to nutrient levelsGO:003210710.021
cell morphogenesisGO:00009022890.021
neuroblast proliferationGO:000740520.021
wnt signaling pathwayGO:0016055800.020
regulation of cell differentiationGO:00455951420.020
regulation of protein bindingGO:004339330.020
regulation of cytokine productionGO:000181730.020
meiotic chromosome segregationGO:004513230.020
regulation of exocytosisGO:001715710.020
tube morphogenesisGO:00352393490.020
establishment of localization in cellGO:0051649770.020
peptidyl serine phosphorylationGO:001810510.020
regulation of intracellular signal transductionGO:1902531570.020
regulation of molecular functionGO:0065009700.020
pigmentationGO:0043473850.020
regulation of biological qualityGO:00650082630.020
mitotic dna damage checkpointGO:004477340.020
morphogenesis of an epitheliumGO:00020093330.020
regulation of apoptotic processGO:0042981980.019
macromolecular complex subunit organizationGO:0043933740.019
Fly
negative regulation of response to stimulusGO:00485851040.019
regulation of multicellular organismal processGO:00512392770.019
protein acylationGO:004354330.019
regulation of defense responseGO:0031347140.019
regulation of gtpase activityGO:004308720.019
glucose importGO:004632320.019
regulation of carbohydrate metabolic processGO:000610940.019
negative regulation of cell communicationGO:0010648960.019
regulation of synaptic plasticityGO:004816710.019
cell projection organizationGO:00300302840.019
negative regulation of signal transductionGO:0009968940.019
regulation of transcription from rna polymerase ii promoterGO:00063571140.019
regulation of transportGO:0051049450.018
negative regulation of mapk cascadeGO:004340940.018
fin developmentGO:0033333770.018
cellular component assembly involved in morphogenesisGO:00109271070.018
stem cell maintenanceGO:001982740.018
negative regulation of cellular metabolic processGO:0031324770.018
cell part morphogenesisGO:00329902460.018
hormone secretionGO:004687920.018
localization of cellGO:00516742440.018
response to uvGO:000941130.018
positive regulation of jun kinase activityGO:004350720.018
regulation of protein polymerizationGO:003227120.018
positive regulation of apoptotic signaling pathwayGO:200123510.018
cellular localizationGO:0051641970.018
regulation of rho protein signal transductionGO:003502320.018
cellular protein modification processGO:00064641000.018
embryonic skeletal system morphogenesisGO:0048704930.017
positive regulation of protein kinase b signalingGO:005189710.017
establishment of synaptic vesicle localizationGO:009748010.017
positive regulation of exocytosisGO:004592110.017
intracellular mrna localizationGO:000829810.017
g1 s transition of mitotic cell cycleGO:000008210.017
digestive tract developmentGO:00485652650.017
regulation of meiotic cell cycleGO:005144510.017
mesenchymal cell differentiationGO:0048762870.017
protein phosphorylationGO:0006468470.017
protein polymerizationGO:005125840.017
regulation of leukocyte mediated immunityGO:000270310.017
regulation of neuron differentiationGO:0045664560.017
neuromuscular process controlling balanceGO:005088530.017
protein localization to plasma membraneGO:007265910.017
circadian sleep wake cycle sleepGO:005080210.016
muscle cell differentiationGO:00426921390.016
regulation of natural killer cell mediated cytotoxicityGO:004226910.016
transcription from rna polymerase ii promoterGO:0006366800.016
skin developmentGO:0043588540.016
regulation of jun kinase activityGO:004350630.016
natural killer cell mediated cytotoxicityGO:004226710.016
protein acetylationGO:000647320.016
response to unfolded proteinGO:000698620.016
regulation of mitotic cell cycleGO:0007346250.016
positive regulation of signalingGO:0023056560.016
striated muscle cell developmentGO:00550021080.016
cellular response to lipopolysaccharideGO:007122230.016
neuron migrationGO:0001764220.016
hematopoietic or lymphoid organ developmentGO:00485341910.016
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.016
centrosome duplicationGO:005129810.016
regulation of photoreceptor cell differentiationGO:004653220.016
cellular response to radiationGO:007147840.016
regulation of programmed cell deathGO:00430671010.016
cellular response to chemical stimulusGO:00708871570.016
positive regulation of histone modificationGO:003105810.016
developmental pigmentationGO:0048066480.016
development of primary female sexual characteristicsGO:004654540.016
er nucleus signaling pathwayGO:000698420.015
heart developmentGO:00075073130.015
central nervous system developmentGO:00074173870.015
regulation of ras gtpase activityGO:003231820.015
neuron neuron synaptic transmissionGO:000727010.015
positive regulation of dna metabolic processGO:005105410.015
regulation of response to extracellular stimulusGO:003210410.015
sleepGO:003043110.015
circadian sleep wake cycleGO:004274520.015
cell cycle arrestGO:000705010.015
cellular response to biotic stimulusGO:007121630.015
signal transduction in absence of ligandGO:003803410.015
protein polyubiquitinationGO:000020940.015
regulation of multicellular organismal developmentGO:20000262230.015
protein complex assemblyGO:0006461300.015
Fly
regulation of reactive oxygen species metabolic processGO:200037720.015
regulation of circadian sleep wake cycle sleepGO:004518710.015
regulation of anatomical structure morphogenesisGO:00226031300.015
negative regulation of tor signalingGO:003200720.015
regulation of organelle assemblyGO:190211540.015
nuclear envelope organizationGO:000699820.015
mitotic g2 dna damage checkpointGO:000709530.015
entrainment of circadian clockGO:000964920.015
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.015
regulation of neurogenesisGO:0050767870.015
cell fate commitmentGO:0045165990.015
rho protein signal transductionGO:000726650.015
positive regulation of gtp catabolic processGO:003312610.015
muscle organ developmentGO:00075171010.015
negative regulation of defense responseGO:003134820.015
lamellipodium assemblyGO:003003210.015
regulation of dendrite morphogenesisGO:004881430.015
spermatid developmentGO:000728620.015
striated muscle tissue developmentGO:00147061100.014
lamellipodium organizationGO:009758110.014
muscle tissue developmentGO:00605371100.014
internal protein amino acid acetylationGO:000647520.014
carbohydrate homeostasisGO:003350010.014
regulation of circadian sleep wake cycleGO:004274910.014
internal peptidyl lysine acetylationGO:001839320.014
establishment of cell polarityGO:0030010180.014
innate immune responseGO:0045087130.014
cellular component disassemblyGO:002241110.014
regulation of lipid transportGO:003236840.014
positive regulation of signal transductionGO:0009967560.014
regulation of cytokine mediated signaling pathwayGO:000195930.014
regulation of glucose transportGO:001082710.014
peptidyl serine modificationGO:001820920.014
female sex differentiationGO:004666040.014
ameboidal type cell migrationGO:00016671430.014
negative regulation of catalytic activityGO:0043086210.014
response to hexoseGO:000974630.014
hypothalamus cell differentiationGO:002197940.014
positive regulation of macromolecule metabolic processGO:0010604930.014
regulation of cell shapeGO:000836010.014
synaptic vesicle transportGO:004848910.014
regulation of cellular protein catabolic processGO:190336210.014
positive regulation of glucose transportGO:001082810.014
mitochondrion organizationGO:000700540.014
positive regulation of nitrogen compound metabolic processGO:0051173690.014
regulation of synapse assemblyGO:005196330.014
cellular macromolecule localizationGO:0070727210.014
reactive oxygen species biosynthetic processGO:190340910.014
convergent extensionGO:00600261180.013
circadian sleep wake cycle processGO:002241020.013
cortical cytoskeleton organizationGO:003086510.013
negative regulation of autophagyGO:001050710.013
mesenchymal cell developmentGO:0014031780.013
regulation of dna replicationGO:000627530.013
skeletal muscle organ developmentGO:0060538780.013
endoplasmic reticulum unfolded protein responseGO:003096820.013
female gonad developmentGO:000858540.013
regulation of microtubule cytoskeleton organizationGO:007050730.013
compound eye developmentGO:004874920.013
rna localizationGO:000640340.013
cellular catabolic processGO:0044248270.013
Fly
positive regulation of natural killer cell mediated immunityGO:000271710.013
positive regulation of cell communicationGO:0010647560.013
somatic muscle developmentGO:000752540.013
activation of mapk activityGO:000018730.013
response to monosaccharideGO:003428430.013
regulation of epithelial to mesenchymal transitionGO:001071730.013
cellular amide metabolic processGO:004360340.013
positive regulation of chromatin modificationGO:190331010.013
positive regulation of jnk cascadeGO:004633030.013
developmental growth involved in morphogenesisGO:0060560860.013
chromosome organization involved in meiosisGO:007019210.013
regulation of hydrolase activityGO:0051336280.013
developmental programmed cell deathGO:001062340.013
adherens junction organizationGO:003433240.013
cellular response to topologically incorrect proteinGO:003596720.013
response to abiotic stimulusGO:00096281220.013
meiosis iGO:000712710.013
toll like receptor signaling pathwayGO:000222440.012
regulation of neural precursor cell proliferationGO:200017730.012
interspecies interaction between organismsGO:004441940.012
nuclear exportGO:005116810.012
regulation of myotube differentiationGO:001083020.012
wound healingGO:0042060900.012
regulation of glucose importGO:004632410.012
intracellular transportGO:0046907320.012
regulation of mitotic cell cycle phase transitionGO:190199080.012
carbohydrate biosynthetic processGO:001605110.012
neural crest formationGO:0014029140.012
protein stabilizationGO:005082120.012
synapsisGO:000712910.012
tissue remodelingGO:004877140.012
organism emergence from protective structureGO:007168440.012
symbiosis encompassing mutualism through parasitismGO:004440340.012
positive regulation of canonical wnt signaling pathwayGO:009026340.012
peptidyl lysine acetylationGO:001839420.012
cellular response to molecule of bacterial originGO:007121930.012
regulation of jak stat cascadeGO:004642530.012
forebrain regionalizationGO:002187140.012

ppp2r5ea disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.039
disease of cellular proliferationDOID:1456600.021
cancerDOID:16200.021
nervous system diseaseDOID:86300.017