IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

sulf2

sulfatase 2

(Aliases: MGC55612,zgc:55612,Sulf1)

Entrez: 393910
Ensembl: ENSDARG00000018423
ZFIN: ZDB-GENE-040426-759
UniProtKB: A5WUS2
UniProtKB: Q7ZVU8

Process Predictions
Disease Predictions

sulf2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
locomotion	GO:0040011	313	0.948	Zebrafish Fly
sensory organ morphogenesis	GO:0090596	200	0.881
blood vessel morphogenesis	GO:0048514	216	0.723	Zebrafish
regulation of cell morphogenesis	GO:0022604	42	0.720
cell surface receptor signaling pathway	GO:0007166	325	0.700	Human Zebrafish Mouse Fly
axonogenesis	GO:0007409	152	0.700	Fly
cell part morphogenesis	GO:0032990	246	0.692	Fly
regulation of neurogenesis	GO:0050767	87	0.673
central nervous system development	GO:0007417	387	0.665	Zebrafish
cell projection organization	GO:0030030	284	0.664	Fly
neuron projection morphogenesis	GO:0048812	161	0.660	Fly
specification of symmetry	GO:0009799	204	0.652
regulation of cell communication	GO:0010646	232	0.631	Human Mouse Fly
cellular biosynthetic process	GO:0044249	286	0.629
regulation of axonogenesis	GO:0050770	32	0.618
regulation of signaling	GO:0023051	235	0.606	Human Mouse Fly
cell migration	GO:0016477	237	0.589	Zebrafish
regulation of cell development	GO:0060284	100	0.549
regulation of neuron projection development	GO:0010975	40	0.540
cellular nitrogen compound metabolic process	GO:0034641	290	0.535
cell morphogenesis	GO:0000902	289	0.499	Fly
determination of bilateral symmetry	GO:0009855	204	0.466
tube morphogenesis	GO:0035239	349	0.465
cellular aromatic compound metabolic process	GO:0006725	295	0.460
axon development	GO:0061564	166	0.460	Fly
sensory organ development	GO:0007423	393	0.451	Zebrafish
neuron differentiation	GO:0030182	353	0.441	Fly
digestive tract morphogenesis	GO:0048546	231	0.428
regulation of developmental process	GO:0050793	247	0.428	Zebrafish
regulation of cell differentiation	GO:0045595	142	0.414
vasculature development	GO:0001944	278	0.412	Zebrafish
embryonic organ development	GO:0048568	381	0.412
response to wounding	GO:0009611	116	0.409
axon guidance	GO:0007411	86	0.391	Fly
cell motility	GO:0048870	244	0.386	Zebrafish
neural tube development	GO:0021915	62	0.382
negative regulation of biological process	GO:0048519	304	0.378	Zebrafish Mouse Fly
cellular component morphogenesis	GO:0032989	336	0.373	Fly
positive regulation of biological process	GO:0048518	253	0.372	Human Mouse Fly
transcription dna templated	GO:0006351	181	0.367
camera type eye morphogenesis	GO:0048593	108	0.364
digestive system development	GO:0055123	289	0.360
neuron projection development	GO:0031175	180	0.357	Fly
hindbrain development	GO:0030902	91	0.357
neuromast development	GO:0048884	46	0.357	Zebrafish
neuron projection guidance	GO:0097485	86	0.352	Fly
brain development	GO:0007420	293	0.349
response to external stimulus	GO:0009605	264	0.341	Fly
hair cell differentiation	GO:0035315	32	0.341
cellular component biogenesis	GO:0044085	178	0.336
morphogenesis of an epithelium	GO:0002009	333	0.329
response to monosaccharide	GO:0034284	3	0.325
digestive tract development	GO:0048565	265	0.315
innervation	GO:0060384	3	0.314	Mouse
head development	GO:0060322	303	0.313
wnt signaling pathway	GO:0016055	80	0.311	Human Fly
response to glucose	GO:0009749	3	0.310
regulation of neuron differentiation	GO:0045664	56	0.310
nucleobase containing compound biosynthetic process	GO:0034654	205	0.307
convergent extension	GO:0060026	118	0.303
organic cyclic compound metabolic process	GO:1901360	301	0.296
determination of left right symmetry	GO:0007368	179	0.290
response to abiotic stimulus	GO:0009628	122	0.288
taxis	GO:0042330	109	0.286	Fly
response to carbohydrate	GO:0009743	3	0.277
neuron development	GO:0048666	262	0.275	Fly
nucleobase containing compound metabolic process	GO:0006139	274	0.270
retina morphogenesis in camera type eye	GO:0060042	79	0.263
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.262	Mouse Fly
mechanoreceptor differentiation	GO:0042490	37	0.252
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.246
generation of neurons	GO:0048699	385	0.239	Fly
eye development	GO:0001654	277	0.233
regulation of cellular component size	GO:0032535	30	0.231
chordate embryonic development	GO:0043009	271	0.231	Zebrafish Mouse
regulation of anatomical structure morphogenesis	GO:0022603	130	0.223
regulation of signal transduction	GO:0009966	225	0.218	Human Mouse Fly
regulation of response to stimulus	GO:0048583	269	0.217	Human Mouse Fly
mesoderm development	GO:0007498	88	0.210
chemotaxis	GO:0006935	104	0.207	Fly
camera type eye development	GO:0043010	222	0.203
angiogenesis	GO:0001525	158	0.201
regulation of nitrogen compound metabolic process	GO:0051171	251	0.196
cell projection morphogenesis	GO:0048858	244	0.192	Fly
positive regulation of signal transduction	GO:0009967	56	0.188	Human Fly
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.183
signal transduction	GO:0007165	455	0.181	Human Zebrafish Mouse Fly
response to hexose	GO:0009746	3	0.181
neuroblast proliferation	GO:0007405	2	0.180
kidney development	GO:0001822	92	0.177	Mouse
death	GO:0016265	121	0.172
embryonic skeletal system development	GO:0048706	97	0.171	Mouse
cell migration involved in gastrulation	GO:0042074	79	0.162
cell proliferation	GO:0008283	80	0.161
response to stress	GO:0006950	263	0.159
dorsal ventral pattern formation	GO:0009953	125	0.157	Zebrafish
regulation of nucleic acid templated transcription	GO:1903506	213	0.153
single organism transport	GO:0044765	206	0.151
regulation of rna biosynthetic process	GO:2001141	213	0.151
regulation of gene expression	GO:0010468	265	0.148
eye morphogenesis	GO:0048592	144	0.147
larval development	GO:0002164	2	0.142
rna metabolic process	GO:0016070	219	0.141
regulation of dendrite development	GO:0050773	3	0.140
regulation of macromolecule biosynthetic process	GO:0010556	225	0.140
positive regulation of translation	GO:0045727	1	0.139
negative regulation of neurogenesis	GO:0050768	20	0.135
sprouting angiogenesis	GO:0002040	53	0.134
regulation of cell shape	GO:0008360	1	0.127
ear development	GO:0043583	127	0.126
chondrocyte development	GO:0002063	4	0.119	Mouse
neural tube formation	GO:0001841	16	0.117
extracellular structure organization	GO:0043062	27	0.116	Mouse
phosphate containing compound metabolic process	GO:0006796	108	0.116
cellular response to organic substance	GO:0071310	105	0.114	Mouse Fly
epithelial cell differentiation	GO:0030855	116	0.112
cellular response to fibroblast growth factor stimulus	GO:0044344	22	0.112	Mouse
negative regulation of signal transduction	GO:0009968	94	0.111	Mouse Fly
developmental growth	GO:0048589	166	0.110
response to chemical	GO:0042221	320	0.109	Mouse Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.109	Fly
synaptic growth at neuromuscular junction	GO:0051124	2	0.107
regulation of establishment of protein localization	GO:0070201	4	0.104
glucose import	GO:0046323	2	0.104
cell proliferation in midbrain	GO:0033278	4	0.104
single organism localization	GO:1902578	225	0.103
inner ear morphogenesis	GO:0042472	63	0.103
regeneration	GO:0031099	91	0.101
regulation of multicellular organismal development	GO:2000026	223	0.101	Zebrafish
aorta development	GO:0035904	4	0.101
somite development	GO:0061053	96	0.101	Zebrafish
apoptotic process	GO:0006915	116	0.100
regulation of cellular metabolic process	GO:0031323	320	0.100
regulation of biological quality	GO:0065008	263	0.098
neuron projection extension	GO:1990138	45	0.098
regulation of localization	GO:0032879	104	0.098	Zebrafish
cell morphogenesis involved in differentiation	GO:0000904	195	0.095	Fly
single organism organelle organization	GO:1902589	199	0.095
regionalization	GO:0003002	274	0.093	Zebrafish
epithelial cell morphogenesis	GO:0003382	2	0.093
regulation of wnt signaling pathway	GO:0030111	53	0.093	Human Fly
positive regulation of cell communication	GO:0010647	56	0.092	Human Fly
cell growth	GO:0016049	57	0.091
peptide transport	GO:0015833	1	0.089
cellular component movement	GO:0006928	335	0.087	Zebrafish Fly
axon extension	GO:0048675	45	0.087
cellular component assembly	GO:0022607	170	0.086
organelle localization	GO:0051640	49	0.086
regulation of axon extension	GO:0030516	24	0.084
motor neuron axon guidance	GO:0008045	23	0.084	Fly
positive regulation of developmental process	GO:0051094	50	0.084
cellular response to chemical stimulus	GO:0070887	157	0.083	Mouse Fly
cellular response to endogenous stimulus	GO:0071495	68	0.083	Mouse Fly
nitrogen compound metabolic process	GO:0006807	319	0.083	Fly
rostrocaudal neural tube patterning	GO:0021903	29	0.083
cellular lipid metabolic process	GO:0044255	36	0.082
rna biosynthetic process	GO:0032774	181	0.081
regulation of macromolecule metabolic process	GO:0060255	317	0.081
programmed cell death	GO:0012501	119	0.081
small molecule metabolic process	GO:0044281	77	0.079	Human Mouse Fly
positive regulation of nervous system development	GO:0051962	25	0.078
blood vessel development	GO:0001568	246	0.078	Zebrafish
oxoacid metabolic process	GO:0043436	31	0.078	Human Mouse Fly
positive regulation of response to stimulus	GO:0048584	80	0.078	Human Fly
system process	GO:0003008	185	0.078	Zebrafish Mouse
positive regulation of cell cycle	GO:0045787	3	0.078
nucleic acid metabolic process	GO:0090304	244	0.077
regulation of intracellular protein transport	GO:0033157	3	0.076
growth	GO:0040007	174	0.074
regulation of locomotion	GO:0040012	55	0.071	Zebrafish
macromolecular complex assembly	GO:0065003	35	0.071
hemopoiesis	GO:0030097	183	0.071
regulation of glial cell differentiation	GO:0045685	4	0.071
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.068	Fly
gastrulation	GO:0007369	208	0.068
cognition	GO:0050890	1	0.068
tissue regeneration	GO:0042246	74	0.067
midbrain development	GO:0030901	28	0.067
epidermis development	GO:0008544	48	0.066
synaptic target recognition	GO:0008039	1	0.066	Fly
ear morphogenesis	GO:0042471	64	0.066
inner ear receptor cell differentiation	GO:0060113	29	0.065
bmp signaling pathway	GO:0030509	52	0.065
inner ear development	GO:0048839	126	0.064
heart development	GO:0007507	313	0.064
cartilage development	GO:0051216	96	0.063	Mouse
embryonic heart tube development	GO:0035050	133	0.063
appendage morphogenesis	GO:0035107	56	0.062
positive regulation of cell differentiation	GO:0045597	30	0.062
cellular macromolecule biosynthetic process	GO:0034645	224	0.062
developmental growth involved in morphogenesis	GO:0060560	86	0.062
organelle assembly	GO:0070925	110	0.061
positive regulation of cellular component biogenesis	GO:0044089	3	0.061
cilium morphogenesis	GO:0060271	85	0.060
regulation of synapse organization	GO:0050807	3	0.059
epithelial cell development	GO:0002064	42	0.059
organic substance biosynthetic process	GO:1901576	289	0.059
positive regulation of transport	GO:0051050	2	0.058
regulation of growth	GO:0040008	42	0.057
regulation of apoptotic process	GO:0042981	98	0.057
organic acid metabolic process	GO:0006082	31	0.057	Human Mouse Fly
segmentation	GO:0035282	97	0.057	Zebrafish
skeletal system development	GO:0001501	181	0.054	Mouse
negative regulation of cell communication	GO:0010648	96	0.054	Mouse Fly
negative regulation of response to stimulus	GO:0048585	104	0.052	Mouse Fly
carboxylic acid metabolic process	GO:0019752	22	0.052
renal system development	GO:0072001	94	0.052	Mouse
dendrite guidance	GO:0070983	0	0.052
regulation of vasculature development	GO:1901342	33	0.051
skin development	GO:0043588	54	0.051
formation of primary germ layer	GO:0001704	62	0.051
regulation of cellular biosynthetic process	GO:0031326	245	0.051
establishment of localization	GO:0051234	244	0.050
regulation of cellular component movement	GO:0051270	55	0.050	Zebrafish
regulation of metabolic process	GO:0019222	359	0.050
nuclear import	GO:0051170	3	0.050
organelle organization	GO:0006996	227	0.050
regulation of bmp signaling pathway	GO:0030510	39	0.050
primary neural tube formation	GO:0014020	1	0.049
positive regulation of cellular process	GO:0048522	201	0.048	Human Fly
regulation of protein transport	GO:0051223	3	0.048
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.048	Mouse Fly
regulation of programmed cell death	GO:0043067	101	0.048
hematopoietic or lymphoid organ development	GO:0048534	191	0.047
eye photoreceptor cell differentiation	GO:0001754	45	0.047
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.047
positive regulation of signaling	GO:0023056	56	0.047	Human Fly
negative regulation of axonogenesis	GO:0050771	7	0.046
protein metabolic process	GO:0019538	183	0.046	Human Mouse
cellular ketone metabolic process	GO:0042180	11	0.046
inner ear receptor cell development	GO:0060119	20	0.046
photoreceptor cell differentiation	GO:0046530	55	0.046
regulation of tyrosine phosphorylation of stat3 protein	GO:0042516	1	0.045
neuromast deposition	GO:0048885	9	0.044	Zebrafish
wound healing	GO:0042060	90	0.043
regulation of synapse assembly	GO:0051963	3	0.043
regulation of angiogenesis	GO:0045765	26	0.043
negative regulation of neuron differentiation	GO:0045665	10	0.042
urogenital system development	GO:0001655	97	0.042	Mouse
hormone transport	GO:0009914	2	0.042
morphogenesis of an epithelial sheet	GO:0002011	49	0.042
cilium organization	GO:0044782	71	0.041
negative regulation of macromolecule metabolic process	GO:0010605	76	0.041
notochord development	GO:0030903	54	0.041
auditory receptor cell development	GO:0060117	8	0.041
aorta morphogenesis	GO:0035909	3	0.041
regulation of multicellular organismal process	GO:0051239	277	0.040	Zebrafish Mouse
cell death	GO:0008219	121	0.040
macromolecular complex subunit organization	GO:0043933	74	0.040
immune system process	GO:0002376	241	0.040
glial cell differentiation	GO:0010001	42	0.039
negative regulation of gene expression	GO:0010629	65	0.039
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.039	Fly
mechanosensory lateral line system development	GO:0048881	49	0.039
morphogenesis of embryonic epithelium	GO:0016331	30	0.039
venous endothelial cell migration involved in lymph vessel development	GO:0060855	4	0.039
positive regulation of neuron differentiation	GO:0045666	12	0.038
spinal cord patterning	GO:0021511	6	0.038	Zebrafish
regulation of protein complex assembly	GO:0043254	3	0.038
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.037
biosynthetic process	GO:0009058	294	0.037
cellular component assembly involved in morphogenesis	GO:0010927	107	0.037
multicellular organism growth	GO:0035264	4	0.036
negative regulation of cell development	GO:0010721	26	0.036
regulation of nervous system development	GO:0051960	90	0.036
forebrain development	GO:0030900	96	0.036
pigmentation	GO:0043473	85	0.036	Zebrafish
cardiac cell fate commitment	GO:0060911	1	0.035
negative regulation of gliogenesis	GO:0014014	1	0.035
regulation of cell proliferation	GO:0042127	37	0.035
heterocycle metabolic process	GO:0046483	290	0.034
negative regulation of cellular process	GO:0048523	283	0.034	Zebrafish Mouse Fly
embryonic appendage morphogenesis	GO:0035113	30	0.034
regulation of cell migration	GO:0030334	40	0.033	Zebrafish
cytoskeleton organization	GO:0007010	96	0.033
response to fibroblast growth factor	GO:0071774	22	0.033	Mouse
heterocycle biosynthetic process	GO:0018130	215	0.033
cellular protein modification process	GO:0006464	100	0.033
neuron projection regeneration	GO:0031102	16	0.033
lateral line system development	GO:0048925	76	0.033	Zebrafish
regulation of rna metabolic process	GO:0051252	224	0.033
positive regulation of multicellular organismal process	GO:0051240	52	0.032	Mouse
cell cycle g1 s phase transition	GO:0044843	1	0.032
fin morphogenesis	GO:0033334	53	0.032
phagocytosis	GO:0006909	3	0.032
microtubule based process	GO:0007017	60	0.032
regulation of cellular component organization	GO:0051128	86	0.031
anterior posterior pattern specification	GO:0009952	152	0.031	Zebrafish
regulation of cell death	GO:0010941	103	0.031
post embryonic organ morphogenesis	GO:0048563	1	0.031
extracellular matrix organization	GO:0030198	27	0.030	Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.030
response to organic substance	GO:0010033	153	0.030	Mouse Fly
regulation of cell size	GO:0008361	29	0.030
cellular macromolecule metabolic process	GO:0044260	391	0.029	Human Mouse
actin cytoskeleton organization	GO:0030036	63	0.029
negative chemotaxis	GO:0050919	1	0.029	Fly
auditory receptor cell fate commitment	GO:0009912	4	0.029
guanosine containing compound metabolic process	GO:1901068	4	0.029
single organism metabolic process	GO:0044710	217	0.029	Human Mouse Fly
response to growth factor	GO:0070848	39	0.029	Mouse Fly
negative regulation of cell death	GO:0060548	60	0.029
regulation of cell motility	GO:2000145	46	0.028	Zebrafish
protein complex subunit organization	GO:0071822	46	0.028
regulation of intracellular signal transduction	GO:1902531	57	0.028
regulation of protein localization to nucleus	GO:1900180	2	0.027
hypochord development	GO:0055016	3	0.027
epithelial tube formation	GO:0072175	19	0.027
glial cell proliferation	GO:0014009	4	0.027
endocrine system development	GO:0035270	65	0.027
regulation of anatomical structure size	GO:0090066	33	0.027
negative regulation of protein phosphorylation	GO:0001933	4	0.027
medulla oblongata development	GO:0021550	4	0.026
otolith development	GO:0048840	32	0.026
regulation of molecular function	GO:0065009	70	0.026
nucleic acid templated transcription	GO:0097659	181	0.026
negative regulation of protein transport	GO:0051224	3	0.026
negative regulation of programmed cell death	GO:0043069	58	0.026
b cell activation	GO:0042113	2	0.025
metencephalon development	GO:0022037	27	0.025
transport	GO:0006810	220	0.025
hepaticobiliary system development	GO:0061008	98	0.025
transcription from rna polymerase ii promoter	GO:0006366	80	0.025
negative regulation of cell migration	GO:0030336	17	0.025	Zebrafish
localization of cell	GO:0051674	244	0.025	Zebrafish
nerve development	GO:0021675	45	0.024	Mouse
epiboly	GO:0090504	41	0.024
negative regulation of metabolic process	GO:0009892	86	0.024
embryonic pectoral fin morphogenesis	GO:0035118	24	0.024
response to temperature stimulus	GO:0009266	15	0.024
regulation of dendrite morphogenesis	GO:0048814	3	0.024
gland development	GO:0048732	143	0.024
regulation of cell growth	GO:0001558	29	0.024
lateral line development	GO:0048882	66	0.024	Zebrafish
regulation of protein targeting	GO:1903533	2	0.024
determination of pancreatic left right asymmetry	GO:0035469	11	0.024
sleep	GO:0030431	1	0.024
convergent extension involved in organogenesis	GO:0060029	10	0.023
posttranscriptional regulation of gene expression	GO:0010608	14	0.023
negative regulation of endothelial cell migration	GO:0010596	1	0.023
regulation of cell activation	GO:0050865	1	0.023
ameboidal type cell migration	GO:0001667	143	0.023
stem cell maintenance	GO:0019827	4	0.023
defense response to fungus	GO:0050832	2	0.023
lateral inhibition	GO:0046331	1	0.022
cellular response to growth factor stimulus	GO:0071363	39	0.022	Mouse Fly
cell cell signaling	GO:0007267	52	0.022
negative regulation of multicellular organismal process	GO:0051241	69	0.022
phosphorus metabolic process	GO:0006793	109	0.022
g1 s transition of mitotic cell cycle	GO:0000082	1	0.021
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.021
inner ear receptor cell fate commitment	GO:0060120	4	0.021
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.021	Mouse Fly
phagocytosis engulfment	GO:0006911	1	0.020
positive regulation of wnt signaling pathway	GO:0030177	13	0.020	Human
regulation of nucleocytoplasmic transport	GO:0046822	2	0.019
response to biotic stimulus	GO:0009607	97	0.019
reproduction	GO:0000003	40	0.019
regulation of neural precursor cell proliferation	GO:2000177	3	0.019
determination of heart left right asymmetry	GO:0061371	117	0.019
macromolecule biosynthetic process	GO:0009059	227	0.019
macromolecule modification	GO:0043412	111	0.019
appendage development	GO:0048736	80	0.019
gene expression	GO:0010467	252	0.019
synapse organization	GO:0050808	21	0.019
intracellular signal transduction	GO:0035556	85	0.019
embryo development ending in birth or egg hatching	GO:0009792	271	0.018	Zebrafish Mouse
rna modification	GO:0009451	2	0.018
peripheral nervous system development	GO:0007422	55	0.018
regulation of biosynthetic process	GO:0009889	250	0.018
cell type specific apoptotic process	GO:0097285	22	0.018
renal filtration	GO:0097205	10	0.018	Mouse
negative regulation of developmental process	GO:0051093	65	0.018
notochord cell differentiation	GO:0060034	18	0.018
liver development	GO:0001889	96	0.018
stem cell proliferation	GO:0072089	4	0.018
regulation of reactive oxygen species metabolic process	GO:2000377	2	0.018
skeletal system morphogenesis	GO:0048705	102	0.018
embryonic organ morphogenesis	GO:0048562	274	0.018
cellular monovalent inorganic cation homeostasis	GO:0030004	2	0.017
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.017	Mouse
cell cycle arrest	GO:0007050	1	0.017
regulation of extent of cell growth	GO:0061387	29	0.017
developmental process involved in reproduction	GO:0003006	27	0.017
response to nutrient	GO:0007584	3	0.017
organic substance transport	GO:0071702	58	0.017
aging	GO:0007568	2	0.017
protein kinase b signaling	GO:0043491	9	0.016
embryonic epithelial tube formation	GO:0001838	17	0.016
negative regulation of intracellular protein transport	GO:0090317	3	0.016
cell cycle process	GO:0022402	53	0.016
negative regulation of signaling	GO:0023057	96	0.016	Mouse Fly
spinal cord dorsal ventral patterning	GO:0021513	5	0.016	Zebrafish
negative regulation of cell differentiation	GO:0045596	46	0.016
central nervous system neuron development	GO:0021954	29	0.016
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.016
positive regulation of cellular metabolic process	GO:0031325	94	0.016
lipid storage	GO:0019915	1	0.016
pancreatic a cell development	GO:0003322	2	0.016
optic nerve morphogenesis	GO:0021631	6	0.016
venous blood vessel development	GO:0060841	9	0.015
protein complex biogenesis	GO:0070271	30	0.015
patterning of lymph vessels	GO:0060854	1	0.015
heart looping	GO:0001947	94	0.015
long chain fatty acid biosynthetic process	GO:0042759	1	0.015
regulation of exocytosis	GO:0017157	1	0.015
protein secretion	GO:0009306	1	0.015
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.015
nucleus localization	GO:0051647	8	0.015
renal system process	GO:0003014	14	0.015	Mouse
astrocyte differentiation	GO:0048708	1	0.015
organic cyclic compound biosynthetic process	GO:1901362	223	0.015
methylation	GO:0032259	22	0.015
glucose homeostasis	GO:0042593	1	0.015
hormone secretion	GO:0046879	2	0.014
ventral spinal cord interneuron fate commitment	GO:0060579	3	0.014
endodermal cell differentiation	GO:0035987	19	0.014
smoothened signaling pathway	GO:0007224	30	0.014	Zebrafish Fly
regulation of multicellular organism growth	GO:0040014	4	0.014
protein stabilization	GO:0050821	2	0.014
cellular hormone metabolic process	GO:0034754	19	0.014
regulation of protein metabolic process	GO:0051246	56	0.014
negative regulation of apoptotic process	GO:0043066	55	0.014
dna methylation	GO:0006306	8	0.014
positive regulation of cellular protein metabolic process	GO:0032270	22	0.014
regulation of developmental growth	GO:0048638	38	0.014
response to fungus	GO:0009620	25	0.014
macromolecule methylation	GO:0043414	19	0.014
sensory perception	GO:0007600	39	0.014
epithelial tube morphogenesis	GO:0060562	148	0.014
neural retina development	GO:0003407	49	0.014
antimicrobial humoral response	GO:0019730	2	0.014
negative regulation of epithelial cell migration	GO:0010633	1	0.013
regulation of transcription dna templated	GO:0006355	213	0.013
regulation of canonical wnt signaling pathway	GO:0060828	34	0.013
ectodermal placode development	GO:0071696	37	0.013
kupffer s vesicle development	GO:0070121	50	0.013
pectoral fin morphogenesis	GO:0035138	29	0.013
positive regulation of catabolic process	GO:0009896	4	0.013
muscle cell development	GO:0055001	115	0.013
mesoderm formation	GO:0001707	43	0.013
regulation of cellular ketone metabolic process	GO:0010565	7	0.013
single organism membrane organization	GO:0044802	20	0.013
macromolecule catabolic process	GO:0009057	15	0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	20	0.013
embryonic skeletal system morphogenesis	GO:0048704	93	0.013
regulation of phosphorus metabolic process	GO:0051174	43	0.013
positive regulation of cell adhesion	GO:0045785	1	0.013
regulation of cell projection organization	GO:0031344	44	0.013
response to endogenous stimulus	GO:0009719	83	0.013	Mouse Fly
amide transport	GO:0042886	12	0.013
phosphorylation	GO:0016310	69	0.012
negative regulation of axon extension	GO:0030517	7	0.012
specification of axis polarity	GO:0065001	4	0.012
positive regulation of neuron apoptotic process	GO:0043525	1	0.012
neuromuscular junction development	GO:0007528	9	0.012
megakaryocyte development	GO:0035855	1	0.012
symbiosis encompassing mutualism through parasitism	GO:0044403	4	0.012
central nervous system neuron differentiation	GO:0021953	74	0.012
stem cell division	GO:0017145	1	0.012
regulation of protein ubiquitination	GO:0031396	3	0.012
gastrulation with mouth forming second	GO:0001702	44	0.012
cell activation	GO:0001775	16	0.012
retina development in camera type eye	GO:0060041	146	0.012
response to acid chemical	GO:0001101	17	0.012
cellular protein metabolic process	GO:0044267	129	0.012
positive regulation of molecular function	GO:0044093	33	0.012
actin filament based process	GO:0030029	64	0.012
mesodermal cell fate specification	GO:0007501	12	0.012
glucose transport	GO:0015758	6	0.012
negative regulation of cellular biosynthetic process	GO:0031327	55	0.012
regulation of gastrulation	GO:0010470	24	0.012
carbohydrate homeostasis	GO:0033500	1	0.012
protein modification process	GO:0036211	100	0.012
brain morphogenesis	GO:0048854	18	0.012
lipid metabolic process	GO:0006629	52	0.011
negative regulation of phosphorus metabolic process	GO:0010563	13	0.011
dna alkylation	GO:0006305	8	0.011
negative regulation of locomotion	GO:0040013	18	0.011	Zebrafish
cranial nerve morphogenesis	GO:0021602	15	0.011
embryonic limb morphogenesis	GO:0030326	2	0.011
positive regulation of cell development	GO:0010720	25	0.011
regulation of catalytic activity	GO:0050790	55	0.011
blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:0002043	4	0.011
dendrite development	GO:0016358	9	0.011
establishment of organelle localization	GO:0051656	45	0.011
spinal cord development	GO:0021510	46	0.011	Zebrafish
regulation of cell migration involved in sprouting angiogenesis	GO:0090049	3	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.011
cellular response to external stimulus	GO:0071496	2	0.011
cell proliferation in forebrain	GO:0021846	3	0.011

sulf2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.077
connective tissue disease	DOID:65	0.020
bone development disease	DOID:0080006	0.020
musculoskeletal system disease	DOID:17	0.020
bone disease	DOID:0080001	0.020
dysostosis	DOID:1934	0.020
nervous system disease	DOID:863	0.013

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