Danio rerio

0 known processes

shdb

Src homology 2 domain containing transforming protein D, b

(Aliases: zgc:153246,si:dkeyp-31e2.2,wu:fi32h10,shd,MGC153246,wu:fb38a12,MGC158798,zgc:153975,zgc:158798)

shdb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.359
embryo development ending in birth or egg hatchingGO:00097922710.357
digestive tract morphogenesisGO:00485462310.230
localization of cellGO:00516742440.166
convergent extension involved in gastrulationGO:0060027710.163
cell motilityGO:00488702440.156
heart developmentGO:00075073130.154
cellular component movementGO:00069283350.152
negative regulation of biological processGO:00485193040.142
cell projection organizationGO:00300302840.133
convergent extensionGO:00600261180.129
cellular component morphogenesisGO:00329893360.122
proepicardium developmentGO:000334240.121
cell migrationGO:00164772370.119
medulla oblongata developmentGO:002155040.119
digestive system developmentGO:00551232890.117
nucleobase containing compound metabolic processGO:00061392740.115
morphogenesis of an epitheliumGO:00020093330.110
vasculature developmentGO:00019442780.109
cellular macromolecule biosynthetic processGO:00346452240.105
tube morphogenesisGO:00352393490.105
nuclear migrationGO:000709730.104
regionalizationGO:00030022740.101
central nervous system developmentGO:00074173870.098
positive regulation of cellular catabolic processGO:003133130.098
positive regulation of oocyte developmentGO:006028210.097
embryonic organ morphogenesisGO:00485622740.090
establishment or maintenance of bipolar cell polarityGO:0061245120.088
gastrulationGO:00073692080.086
agingGO:000756820.083
regulation of reproductive processGO:200024140.083
multi organism processGO:00517041340.082
locomotionGO:00400113130.081
stem cell divisionGO:001714510.078
embryonic heart tube developmentGO:00350501330.077
cellular aromatic compound metabolic processGO:00067252950.075
septum transversum developmentGO:000334340.073
synaptic growth at neuromuscular junctionGO:005112420.071
germ line stem cell divisionGO:004207810.070
reproductive processGO:0022414400.069
ameboidal type cell migrationGO:00016671430.068
regulation of oocyte developmentGO:006028130.065
negative regulation of collateral sproutingGO:004867120.064
stem cell proliferationGO:007208940.061
nitrogen compound metabolic processGO:00068073190.061
dorsal motor nucleus of vagus nerve developmentGO:002174440.060
endodermal cell fate determinationGO:000749320.059
response to abiotic stimulusGO:00096281220.058
regulation of signalingGO:00230512350.058
establishment or maintenance of apical basal cell polarityGO:0035088120.056
heart morphogenesisGO:00030071560.055
eye developmentGO:00016542770.055
regulation of primary metabolic processGO:00800903110.055
aromatic compound biosynthetic processGO:00194382170.054
central nervous system formationGO:002155610.054
cell surface receptor signaling pathwayGO:00071663250.053
immune system processGO:00023762410.053
cell substrate adhesionGO:003158940.053
multicellular organism growthGO:003526440.052
cell cycleGO:0007049930.050
modulation by virus of host morphology or physiologyGO:001904810.050
oocyte maturationGO:000155640.050
lipid storageGO:001991510.049
determination of ventral identityGO:0048264210.049
guanosine containing compound metabolic processGO:190106840.049
positive regulation of transportGO:005105020.048
regulation of multicellular organism growthGO:004001440.048
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.047
positive regulation of reproductive processGO:200024320.046
regulation of signal transductionGO:00099662250.046
cell fate commitment involved in formation of primary germ layerGO:0060795260.045
regulation of cellular metabolic processGO:00313233200.045
heterocycle metabolic processGO:00464832900.044
blood vessel morphogenesisGO:00485142160.044
brain developmentGO:00074202930.043
single organism metabolic processGO:00447102170.043
negative regulation of signal transductionGO:0009968940.043
multi organism reproductive processGO:0044703360.042
regulation of gtp catabolic processGO:003312420.042
organonitrogen compound metabolic processGO:1901564740.042
regulation of mrna processingGO:005068430.041
forebrain developmentGO:0030900960.041
negative regulation of response to stimulusGO:00485851040.040
regulation of synaptic growth at neuromuscular junctionGO:000858210.040
gtp catabolic processGO:000618420.039
positive regulation of stress activated mapk cascadeGO:003287430.039
muscle structure developmentGO:00610611960.037
negative regulation of calcium dependent cell cell adhesionGO:004658810.037
epithelial tube morphogenesisGO:00605621480.037
regulation of gene expressionGO:00104682650.037
neuroblast proliferationGO:000740520.036
regulation of developmental processGO:00507932470.036
regulation of establishment of protein localizationGO:007020140.036
anterior posterior pattern specificationGO:00099521520.036
negative chemotaxisGO:005091910.036
regulation of organ growthGO:004662030.036
response to external stimulusGO:00096052640.035
response to fluid shear stressGO:003440520.035
embryonic organ developmentGO:00485683810.035
camera type eye developmentGO:00430102220.034
regulation of macromolecule biosynthetic processGO:00105562250.034
regulation of synapse assemblyGO:005196330.034
positive regulation of cell cycleGO:004578730.034
regulation of transcription dna templatedGO:00063552130.033
response to carbohydrateGO:000974330.033
organic substance biosynthetic processGO:19015762890.033
response to chemicalGO:00422213200.033
homeostatic processGO:00425921420.032
regulation of macromolecule metabolic processGO:00602553170.032
single organism localizationGO:19025782250.032
regulation of nucleotide catabolic processGO:003081120.032
exocrine pancreas developmentGO:0031017280.032
regulation of purine nucleotide catabolic processGO:003312120.032
single organism reproductive processGO:0044702400.031
regulation of glucose transportGO:001082710.031
organic cyclic compound biosynthetic processGO:19013622230.031
forebrain cell migrationGO:002188510.031
notochord morphogenesisGO:0048570170.031
neuron projection developmentGO:00311751800.030
determination of bilateral symmetryGO:00098552040.030
eye morphogenesisGO:00485921440.030
taxisGO:00423301090.030
camera type eye morphogenesisGO:00485931080.030
cell morphogenesisGO:00009022890.030
positive regulation of cellular component biogenesisGO:004408930.030
guanosine containing compound catabolic processGO:190106920.030
establishment of localizationGO:00512342440.030
regulation of cell communicationGO:00106462320.029
response to nutrientGO:000758430.029
cellular nitrogen compound metabolic processGO:00346412900.029
maintenance of locationGO:005123540.029
response to organic substanceGO:00100331530.029
regulation of biological qualityGO:00650082630.029
epidermis developmentGO:0008544480.029
regulation of nucleoside metabolic processGO:000911820.029
regulation of neuron projection regenerationGO:007057070.029
regulation of metabolic processGO:00192223590.029
cell projection morphogenesisGO:00488582440.028
zymogen activationGO:003163830.028
gene expressionGO:00104672520.028
positive regulation of gtp catabolic processGO:003312610.028
embryonic heart tube morphogenesisGO:00031431080.028
single organism organelle organizationGO:19025891990.028
developmental growthGO:00485891660.028
cellular macromolecule metabolic processGO:00442603910.028
generation of neuronsGO:00486993850.027
positive regulation of jnk cascadeGO:004633030.027
axon developmentGO:00615641660.027
regulation of protein catabolic processGO:004217610.027
adherens junction organizationGO:003433240.027
developmental maturationGO:0021700340.026
head developmentGO:00603223030.026
protein localization to nucleusGO:003450430.026
regulation of gtpase activityGO:004308720.026
regulation of protein transportGO:005122330.026
developmental process involved in reproductionGO:0003006270.026
central nervous system neuron differentiationGO:0021953740.026
response to stressGO:00069502630.026
neuron projection guidanceGO:0097485860.026
developmental growth involved in morphogenesisGO:0060560860.026
cellular response to stressGO:0033554620.026
organelle organizationGO:00069962270.025
cell surface receptor signaling pathway involved in heart developmentGO:0061311200.025
cell fate commitmentGO:0045165990.025
regulation of biosynthetic processGO:00098892500.025
glucose importGO:004632320.025
cell cell recognitionGO:000998810.025
purine ribonucleotide metabolic processGO:0009150270.025
response to corticosteroidGO:003196010.025
negative regulation of macromolecule metabolic processGO:0010605760.025
heart joggingGO:0003146400.025
regulation of synapse organizationGO:005080730.025
regulation of anatomical structure morphogenesisGO:00226031300.024
amine metabolic processGO:000930820.024
phosphate containing compound metabolic processGO:00067961080.024
meiotic cell cycle processGO:190304630.024
gtp metabolic processGO:004603940.024
blood vessel endothelial cell migrationGO:0043534180.024
rna metabolic processGO:00160702190.024
negative regulation of protein phosphorylationGO:000193340.024
regulation of intracellular signal transductionGO:1902531570.023
organic cyclic compound metabolic processGO:19013603010.023
sensory organ morphogenesisGO:00905962000.023
regulation of cellular biosynthetic processGO:00313262450.023
small molecule metabolic processGO:0044281770.023
response to vitaminGO:003327330.023
macromolecule biosynthetic processGO:00090592270.023
axonogenesisGO:00074091520.023
regulation of nucleobase containing compound metabolic processGO:00192192500.023
cellular response to oxygen levelsGO:007145310.023
regulation of cellular carbohydrate metabolic processGO:001067540.023
phagocytosisGO:000690930.023
endodermal cell differentiationGO:0035987190.022
cellular protein modification processGO:00064641000.022
muscle tissue developmentGO:00605371100.022
peptidyl threonine modificationGO:001821010.022
cellular protein catabolic processGO:004425740.022
regulation of phosphate metabolic processGO:0019220430.022
regulation of transcription from rna polymerase ii promoterGO:00063571140.022
regulation of cellular component organizationGO:0051128860.022
circulatory system processGO:0003013870.022
regulation of cell shapeGO:000836010.022
embryonic skeletal system morphogenesisGO:0048704930.022
peptidyl threonine phosphorylationGO:001810710.022
primary neural tube formationGO:001402010.021
cell morphogenesis involved in differentiationGO:00009041950.021
pancreas developmentGO:0031016840.021
positive regulation of multi organism processGO:004390230.021
hematopoietic or lymphoid organ developmentGO:00485341910.021
positive regulation of catabolic processGO:000989640.021
regulation of transcription from rna polymerase ii promoter involved in heart developmentGO:1901213150.021
regulation of stem cell differentiationGO:200073640.020
positive regulation of lipid metabolic processGO:004583410.020
axon guidanceGO:0007411860.020
heart loopingGO:0001947940.020
determination of left right symmetryGO:00073681790.020
nucleic acid templated transcriptionGO:00976591810.020
cytokinesisGO:000091030.020
sensory organ developmentGO:00074233930.020
response to ketoneGO:190165410.019
actin cytoskeleton organizationGO:0030036630.019
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetryGO:1900094170.019
proteolysis involved in cellular protein catabolic processGO:005160330.019
negative regulation of cellular metabolic processGO:0031324770.019
positive regulation of gtpase activityGO:004354710.019
negative regulation of metabolic processGO:0009892860.019
stem cell maintenanceGO:001982740.019
rna biosynthetic processGO:00327741810.019
mitotic cell cycleGO:0000278640.019
defense response to fungusGO:005083220.019
developmental cell growthGO:0048588520.019
b cell activationGO:004211320.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.019
bmp signaling pathwayGO:0030509520.019
nucleic acid metabolic processGO:00903042440.018
reproductionGO:0000003400.018
pericardium developmentGO:006003910.018
determination of heart left right asymmetryGO:00613711170.018
embryonic hemopoiesisGO:0035162530.018
cellular biosynthetic processGO:00442492860.018
leukocyte proliferationGO:007066110.018
gland developmentGO:00487321430.018
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.018
multicellular organismal reproductive processGO:0048609350.018
nucleobase containing compound biosynthetic processGO:00346542050.017
angiogenesisGO:00015251580.017
modification dependent macromolecule catabolic processGO:004363230.017
positive regulation of nucleotide catabolic processGO:003081310.017
regulation of blood vessel sizeGO:005088020.017
growthGO:00400071740.017
regulation of rna biosynthetic processGO:20011412130.017
regulation of cell differentiationGO:00455951420.017
regulation of multicellular organismal developmentGO:20000262230.017
liver developmentGO:0001889960.017
regulation of cell matrix adhesionGO:000195210.017
endoderm formationGO:0001706290.017
cellular component biogenesisGO:00440851780.017
heterocycle biosynthetic processGO:00181302150.017
negative regulation of collateral sprouting of intact axon in response to injuryGO:004868520.017
angioblast cell migration involved in selective angioblast sproutingGO:003547540.017
digestive tract developmentGO:00485652650.017
regulation of carbohydrate metabolic processGO:000610940.016
negative regulation of transcription dna templatedGO:0045892450.016
sexual reproductionGO:0019953360.016
blood vessel developmentGO:00015682460.016
positive regulation of nucleoside metabolic processGO:004597910.016
regulation of response to stimulusGO:00485832690.016
positive regulation of nitrogen compound metabolic processGO:0051173690.016
regulation of cellular macromolecule biosynthetic processGO:20001122220.016
organelle assemblyGO:00709251100.016
regulation of peptidase activityGO:0052547230.016
gamete generationGO:0007276330.016
regulation of tube sizeGO:003515020.016
cell proliferationGO:0008283800.016
response to monosaccharideGO:003428430.016
protein localization to plasma membraneGO:007265910.016
regulation of rho protein signal transductionGO:003502320.016
endodermal cell fate specificationGO:0001714170.016
regulation of nitrogen compound metabolic processGO:00511712510.016
modification by symbiont of host morphology or physiologyGO:004400340.015
neuron developmentGO:00486662620.015
mesenchymal cell developmentGO:0014031780.015
oogenesisGO:0048477140.015
modification of morphology or physiology of other organismGO:003582140.015
striated muscle cell differentiationGO:00511461290.015
retinal ganglion cell axon guidanceGO:0031290350.015
skeletal system developmentGO:00015011810.015
retina morphogenesis in camera type eyeGO:0060042790.015
endodermal cell fate commitmentGO:0001711180.015
negative regulation of cell communicationGO:0010648960.015
peptidyl serine phosphorylationGO:001810510.015
chondrocyte developmentGO:000206340.015
hypothalamus cell differentiationGO:002197940.015
response to radiationGO:0009314510.014
germ line stem cell maintenanceGO:003071820.014
lymphocyte proliferationGO:004665110.014
regulation of cellular ketone metabolic processGO:001056570.014
signal transductionGO:00071654550.014
positive regulation of map kinase activityGO:004340630.014
embryonic medial fin morphogenesisGO:003512260.014
regulation of cell activationGO:005086510.014
embryonic skeletal system developmentGO:0048706970.014
regulation of cell morphogenesisGO:0022604420.014
establishment of mitotic spindle orientationGO:0000132100.014
transcription from rna polymerase ii promoterGO:0006366800.014
positive regulation of purine nucleotide catabolic processGO:003312310.014
formation of primary germ layerGO:0001704620.014
negative regulation of reproductive processGO:200024230.014
neuron projection extensionGO:1990138450.014
mesoderm formationGO:0001707430.014
regulation of cell deathGO:00109411030.014
ubiquitin dependent protein catabolic processGO:000651130.014
cellular response to nutrient levelsGO:003166920.014
gastrulation with mouth forming secondGO:0001702440.014
cell growthGO:0016049570.014
regulation of sodium ion transportGO:000202820.014
response to biotic stimulusGO:0009607970.014
cellular amine metabolic processGO:004410620.014
cellular response to external stimulusGO:007149620.014
negative regulation of catabolic processGO:000989530.014
positive regulation of metabolic processGO:00098931080.013
regulation of cell substrate adhesionGO:001081010.013
actin filament polymerizationGO:003004120.013
regulation of glucose importGO:004632410.013
carbohydrate derivative metabolic processGO:1901135610.013
enzyme linked receptor protein signaling pathwayGO:00071671060.013
hard palate developmentGO:006002240.013
protein stabilizationGO:005082120.013
cytoskeleton dependent cytokinesisGO:006164030.013
cell matrix adhesionGO:000716040.013
g1 s transition of mitotic cell cycleGO:000008210.013
regulation of catalytic activityGO:0050790550.013
morphogenesis of an epithelial sheetGO:0002011490.013
wnt signaling pathwayGO:0016055800.013
regulation of calcium dependent cell cell adhesionGO:004658610.013
response to axon injuryGO:0048678140.013
negative regulation of cell differentiationGO:0045596460.013
macromolecule localizationGO:0033036540.013
transportGO:00068102200.013
response to woundingGO:00096111160.013
ventral spinal cord developmentGO:0021517350.013
response to vitamin b3GO:003355220.013
positive regulation of molecular functionGO:0044093330.013
carbohydrate biosynthetic processGO:001605110.013
extrinsic apoptotic signaling pathwayGO:009719130.013
polarized epithelial cell differentiationGO:003085940.013
peripheral nervous system neuron differentiationGO:0048934280.012
protein complex subunit organizationGO:0071822460.012
chordate embryonic developmentGO:00430092710.012
positive regulation of cellular metabolic processGO:0031325940.012
retina development in camera type eyeGO:00600411460.012
phosphorus metabolic processGO:00067931090.012
smooth muscle contractionGO:000693920.012
response to endogenous stimulusGO:0009719830.012
nuclear transportGO:005116940.012
cell part morphogenesisGO:00329902460.012
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.012
cell morphogenesis involved in neuron differentiationGO:00486671630.012
regulation of embryonic developmentGO:0045995470.012
pronephros developmentGO:0048793690.012
cardiac chamber developmentGO:0003205190.012
nucleocytoplasmic transportGO:000691340.012
regulation of molecular functionGO:0065009700.012
negative regulation of muscle cell differentiationGO:005114810.012
cell cycle g1 s phase transitionGO:004484310.012
regulation of programmed cell deathGO:00430671010.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.012
development of primary female sexual characteristicsGO:004654540.012
neuron projection morphogenesisGO:00488121610.012
transcription dna templatedGO:00063511810.012
cellular macromolecular complex assemblyGO:0034622240.012
regulation of cytoplasmic transportGO:190364940.012
negative regulation of gene expressionGO:0010629650.012
hindbrain developmentGO:0030902910.011
negative regulation of signalingGO:0023057960.011
myeloid cell developmentGO:0061515320.011
hormone secretionGO:004687920.011
homeostasis of number of cellsGO:0048872620.011
actin filament based processGO:0030029640.011
determination of left right asymmetry in lateral mesodermGO:0003140200.011
epibolyGO:0090504410.011
larval heart developmentGO:000750820.011
response to hexoseGO:000974630.011
germ cell developmentGO:0007281220.011
negative regulation of macromolecule biosynthetic processGO:0010558480.011
regulation of reactive oxygen species metabolic processGO:200037720.011
positive regulation of cell adhesionGO:004578510.011
positive regulation of translationGO:004572710.011
microtubule based processGO:0007017600.011
protein modification processGO:00362111000.011
negative regulation of cellular processGO:00485232830.011
cellular response to hypoxiaGO:007145610.011
negative regulation of axon extensionGO:003051770.011
multicellular organismal homeostasisGO:0048871290.011
mitotic cell cycle processGO:1903047480.011
regulation of epithelial to mesenchymal transitionGO:001071730.011
regulation of meiotic cell cycleGO:005144510.011
regulation of growthGO:0040008420.011
cellular protein metabolic processGO:00442671290.011
intracellular signal transductionGO:0035556850.011
female gamete generationGO:0007292140.011
regulation of chondrocyte differentiationGO:003233010.011
negative regulation of biosynthetic processGO:0009890550.010
cellular response to starvationGO:000926710.010
positive regulation of multicellular organismal processGO:0051240520.010
apoptotic processGO:00069151160.010
chemotaxisGO:00069351040.010
cellular process involved in reproduction in multicellular organismGO:0022412280.010
regulation of protein complex assemblyGO:004325430.010
regulation of translational initiationGO:000644610.010
type b pancreatic cell developmentGO:000332340.010
cell agingGO:000756920.010
specification of symmetryGO:00097992040.010
nucleus localizationGO:005164780.010
regulation of localizationGO:00328791040.010
biosynthetic processGO:00090582940.010

shdb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.042
disease of cellular proliferationDOID:1456600.024
organ system cancerDOID:005068600.024
cancerDOID:16200.024