Danio rerio

49 known processes

sec63

SEC63-like (S. cerevisiae)

(Aliases: zgc:92718,SEC63-like)

sec63 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to external stimulusGO:00096052640.079
positive regulation of cellular catabolic processGO:003133130.075
neuron developmentGO:00486662620.070
multicellular organism growthGO:003526440.063
nitrogen compound metabolic processGO:00068073190.063
Mouse
positive regulation of catabolic processGO:000989640.060
response to chemicalGO:00422213200.060
cognitionGO:005089010.058
neuron differentiationGO:00301823530.058
larval developmentGO:000216420.057
modification dependent macromolecule catabolic processGO:004363230.057
cellular biosynthetic processGO:00442492860.054
heterocycle metabolic processGO:00464832900.054
ubiquitin dependent protein catabolic processGO:000651130.052
generation of neuronsGO:00486993850.050
signal transductionGO:00071654550.048
amine metabolic processGO:000930820.048
regulation of bindingGO:005109830.047
cellular nitrogen compound metabolic processGO:00346412900.047
gland developmentGO:00487321430.047
cellular protein catabolic processGO:004425740.047
nuclear transportGO:005116940.045
proteasomal protein catabolic processGO:001049820.045
cellular component morphogenesisGO:00329893360.044
small molecule metabolic processGO:0044281770.044
cellular aromatic compound metabolic processGO:00067252950.043
mononuclear cell proliferationGO:003294310.043
proteolysis involved in cellular protein catabolic processGO:005160330.043
response to drugGO:004249330.042
maintenance of locationGO:005123540.042
gtp metabolic processGO:004603940.041
cell projection organizationGO:00300302840.041
protein localization to nucleusGO:003450430.041
chemosensory behaviorGO:000763510.040
regulation of cell activationGO:005086510.040
protein importGO:001703830.040
cellular response to external stimulusGO:007149620.040
aromatic compound biosynthetic processGO:00194382170.040
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.039
modification dependent protein catabolic processGO:001994130.039
organic cyclic compound metabolic processGO:19013603010.038
cellular amine metabolic processGO:004410620.038
hepaticobiliary system developmentGO:0061008980.038
regulation of multicellular organismal processGO:00512392770.038
regulation of protein catabolic processGO:004217610.038
neuronal action potentialGO:0019228180.038
gtp catabolic processGO:000618420.037
liver developmentGO:0001889960.037
immune system developmentGO:00025201910.037
nucleic acid metabolic processGO:00903042440.036
cellular response to extracellular stimulusGO:003166820.036
guanosine containing compound metabolic processGO:190106840.036
leukocyte proliferationGO:007066110.036
phosphatidylinositol 3 kinase signalingGO:001406520.036
regulation of cell shapeGO:000836010.036
establishment of protein localization to organelleGO:007259440.035
Human Mouse
locomotionGO:00400113130.035
stem cell maintenanceGO:001982740.035
rna metabolic processGO:00160702190.035
cell projection morphogenesisGO:00488582440.034
nucleocytoplasmic transportGO:000691340.034
morphogenesis of follicular epitheliumGO:001633310.034
cellular response to nutrient levelsGO:003166920.034
cytokinesisGO:000091030.034
regulation of multicellular organism growthGO:004001440.034
guanosine containing compound catabolic processGO:190106920.034
regulation of protein transportGO:005122330.034
agingGO:000756820.034
Mouse
regulation of peptidyl tyrosine phosphorylationGO:005073010.034
ribonucleoside monophosphate catabolic processGO:000915840.034
heterocycle biosynthetic processGO:00181302150.033
single organism transportGO:00447652060.033
Human Mouse
g1 s transition of mitotic cell cycleGO:000008210.033
regulation of establishment of protein localizationGO:007020140.032
nuclear importGO:005117030.032
organelle organizationGO:00069962270.032
cell morphogenesisGO:00009022890.032
regulation of cellular amine metabolic processGO:003323800.032
biosynthetic processGO:00090582940.032
regulation of nucleoside metabolic processGO:000911820.032
atp catabolic processGO:000620040.031
regulation of biological qualityGO:00650082630.031
cellular response to starvationGO:000926710.031
positive regulation of purine nucleotide catabolic processGO:003312310.031
negative regulation of catabolic processGO:000989530.030
action potentialGO:0001508190.030
cell part morphogenesisGO:00329902460.030
autophagyGO:000691440.030
meiotic nuclear divisionGO:000712640.030
multicellular organismal signalingGO:0035637220.030
endosomal transportGO:001619720.029
cellular macromolecule metabolic processGO:00442603910.029
response to topologically incorrect proteinGO:003596620.029
protein import into nucleusGO:000660630.029
positive regulation of transportGO:005105020.029
phagocytosisGO:000690930.029
cell cycle g1 s phase transitionGO:004484310.029
regulation of cellular amino acid metabolic processGO:000652100.029
regulation of cellular ketone metabolic processGO:001056570.029
nucleoside monophosphate catabolic processGO:000912540.028
regulation of nucleotide catabolic processGO:003081120.028
positive regulation of gtpase activityGO:004354710.028
cellular nitrogen compound biosynthetic processGO:00442712180.028
regulation of synaptic plasticityGO:004816710.028
startle responseGO:000196440.028
transportGO:00068102200.027
Human Mouse
exocytosisGO:000688710.027
cellular component disassemblyGO:002241110.027
macromolecular complex disassemblyGO:003298410.027
positive regulation of cell activationGO:005086710.027
single organism nuclear importGO:190259330.027
extrinsic apoptotic signaling pathwayGO:009719130.027
cellular macromolecule biosynthetic processGO:00346452240.026
regulation of gtp catabolic processGO:003312420.026
neuron projection developmentGO:00311751800.026
heart developmentGO:00075073130.026
negative regulation of cellular processGO:00485232830.026
golgi vesicle transportGO:004819330.026
regulation of purine nucleotide catabolic processGO:003312120.026
neurotransmitter secretionGO:000726920.026
nucleobase containing compound metabolic processGO:00061392740.026
compound eye developmentGO:004874920.026
neuron projection morphogenesisGO:00488121610.025
establishment of localizationGO:00512342440.025
Human Mouse
synaptic vesicle transportGO:004848910.025
stem cell proliferationGO:007208940.025
organonitrogen compound metabolic processGO:1901564740.025
positive regulation of nucleoside metabolic processGO:004597910.025
establishment of synaptic vesicle localizationGO:009748010.025
cytoskeleton dependent cytokinesisGO:006164030.025
embryonic organ morphogenesisGO:00485622740.025
protein complex disassemblyGO:004324110.025
enzyme linked receptor protein signaling pathwayGO:00071671060.025
regulation of protein bindingGO:004339330.025
gene expressionGO:00104672520.025
positive regulation of gtp catabolic processGO:003312610.024
protein targeting to nucleusGO:004474430.024
locomotor rhythmGO:004547530.024
purine ribonucleoside monophosphate catabolic processGO:000916940.024
organic cyclic compound biosynthetic processGO:19013622230.024
carboxylic acid metabolic processGO:0019752220.024
vasculature developmentGO:00019442780.023
developmental growthGO:00485891660.023
lymphocyte proliferationGO:004665110.023
meiotic cell cycle processGO:190304630.023
regulation of multicellular organismal developmentGO:20000262230.023
cellular ketone metabolic processGO:0042180110.023
positive regulation of cellular component biogenesisGO:004408930.023
positive regulation of nucleotide catabolic processGO:003081310.022
protein localization to plasma membraneGO:007265910.022
morphogenesis of an epitheliumGO:00020093330.022
immune system processGO:00023762410.022
negative regulation of cellular catabolic processGO:003133030.022
embryonic organ developmentGO:00485683810.022
organic substance biosynthetic processGO:19015762890.022
neurotransmitter transportGO:000683620.022
meiotic chromosome segregationGO:004513230.022
cell migrationGO:00164772370.022
hemopoiesisGO:00300971830.022
axonogenesisGO:00074091520.022
taxisGO:00423301090.022
positive regulation of cellular amine metabolic processGO:003324000.022
cellular component biogenesisGO:00440851780.022
sympathetic nervous system developmentGO:004848530.021
regulation of protein complex assemblyGO:004325430.021
rna localizationGO:000640340.021
regulation of signal transductionGO:00099662250.021
inositol lipid mediated signalingGO:004801720.021
positive regulation of small gtpase mediated signal transductionGO:005105710.021
intracellular signal transductionGO:0035556850.021
negative regulation of protein phosphorylationGO:000193340.021
protein secretionGO:000930610.021
regulation of gtpase activityGO:004308720.021
cell morphogenesis involved in neuron differentiationGO:00486671630.021
regulation of localizationGO:00328791040.021
negative regulation of biological processGO:00485193040.021
nucleobase containing compound biosynthetic processGO:00346542050.021
periodic partitioningGO:000736510.021
cellular amino acid metabolic processGO:000652070.021
synaptic vesicle localizationGO:009747910.021
oxoacid metabolic processGO:0043436310.021
regulation of nucleobase containing compound metabolic processGO:00192192500.021
stem cell divisionGO:001714510.021
peripheral nervous system developmentGO:0007422550.020
regulation of epithelial cell proliferationGO:005067830.020
mitotic dna integrity checkpointGO:004477440.020
single organism localizationGO:19025782250.020
Human Mouse
organelle fusionGO:004828430.020
mechanosensory behaviorGO:000763820.020
hematopoietic or lymphoid organ developmentGO:00485341910.020
regulation of protein ubiquitinationGO:003139630.020
single organism metabolic processGO:00447102170.020
axon developmentGO:00615641660.020
regulation of synapse organizationGO:005080730.020
sequestering of calcium ionGO:005120830.020
heart morphogenesisGO:00030071560.020
transmembrane transportGO:00550851200.020
regulation of autophagyGO:001050630.020
regulation of sequestering of calcium ionGO:005128240.020
positive regulation of secretionGO:005104710.020
regulation of muscle contractionGO:000693730.020
regulation of stem cell proliferationGO:007209120.019
growthGO:00400071740.019
positive regulation of wound healingGO:009030310.019
microtubule based processGO:0007017600.019
positive regulation of glucose transportGO:001082810.019
regulation of cell communicationGO:00106462320.019
regulation of cytokine productionGO:000181730.019
negative regulation of kinase activityGO:003367340.019
phosphatidylinositol mediated signalingGO:004801520.019
organic acid metabolic processGO:0006082310.019
regulation of erk1 and erk2 cascadeGO:007037240.019
regulation of protein import into nucleusGO:004230620.019
regulation of signalingGO:00230512350.019
muscle structure developmentGO:00610611960.019
signal transduction in absence of ligandGO:003803410.019
cellular response to chemical stimulusGO:00708871570.018
production of molecular mediator of immune responseGO:000244020.018
peptidyl serine phosphorylationGO:001810510.018
transcription dna templatedGO:00063511810.018
neurological system processGO:0050877620.018
regulation of protein localization to nucleusGO:190018020.018
cellular component movementGO:00069283350.018
regulation of rna biosynthetic processGO:20011412130.018
regulation of response to stimulusGO:00485832690.018
pigmentationGO:0043473850.018
negative regulation of protein kinase activityGO:000646940.018
macroautophagyGO:001623610.018
mitochondrion organizationGO:000700540.018
regulation of synaptic growth at neuromuscular junctionGO:000858210.018
peptidyl serine modificationGO:001820920.018
regulation of synapse assemblyGO:005196330.018
regulation of cytoplasmic transportGO:190364940.018
positive regulation of biological processGO:00485182530.017
axon guidanceGO:0007411860.017
regulation of protein targetingGO:190353320.017
negative regulation of macromolecule metabolic processGO:0010605760.017
er nucleus signaling pathwayGO:000698420.017
regulation of protein modification by small protein conjugation or removalGO:190332030.017
nucleic acid templated transcriptionGO:00976591810.017
response to uvGO:000941130.017
cellular amide metabolic processGO:004360340.017
sensory organ developmentGO:00074233930.017
regulation of wound healingGO:006104120.017
determination of bilateral symmetryGO:00098552040.017
glial cell migrationGO:000834730.017
regionalizationGO:00030022740.017
positive regulation of map kinase activityGO:004340630.017
brain developmentGO:00074202930.017
specification of symmetryGO:00097992040.017
response to unfolded proteinGO:000698620.017
negative regulation of cytoplasmic transportGO:190365020.017
regulation of metabolic processGO:00192223590.017
regulation of neurogenesisGO:0050767870.017
cell morphogenesis involved in differentiationGO:00009041950.017
neuroblast proliferationGO:000740520.017
peptide transportGO:001583310.017
organelle assemblyGO:00709251100.017
regulation of intracellular protein transportGO:003315730.017
intracellular mrna localizationGO:000829810.017
positive regulation of notch signaling pathwayGO:004574730.016
positive regulation of cellular amino acid metabolic processGO:004576400.016
cell cycle arrestGO:000705010.016
regulation of cellular metabolic processGO:00313233200.016
mitotic dna damage checkpointGO:004477340.016
cell surface receptor signaling pathwayGO:00071663250.016
centrosome organizationGO:005129710.016
regulation of cellular protein catabolic processGO:190336210.016
germ line stem cell maintenanceGO:003071820.016
striated muscle tissue developmentGO:00147061100.016
regulation of cell substrate adhesionGO:001081010.016
neuron projection guidanceGO:0097485860.016
rna biosynthetic processGO:00327741810.016
cell cycle g2 m phase transitionGO:004483940.016
response to organic substanceGO:00100331530.016
sequestering of metal ionGO:005123830.016
positive regulation of cellular processGO:00485222010.016
regulation of nitrogen compound metabolic processGO:00511712510.016
regulation of nucleocytoplasmic transportGO:004682220.016
protein metabolic processGO:00195381830.016
regulation of cellular biosynthetic processGO:00313262450.016
neuromuscular synaptic transmissionGO:000727420.016
response to stressGO:00069502630.016
cell substrate adhesionGO:003158940.016
negative regulation of protein transportGO:005122430.016
regulation of developmental processGO:00507932470.016
response to abiotic stimulusGO:00096281220.016
positive regulation of secretion by cellGO:190353210.016
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.015
calcium ion transport into cytosolGO:006040230.015
internal protein amino acid acetylationGO:000647520.015
microtubule organizing center organizationGO:003102310.015
cell matrix adhesionGO:000716040.015
lipid storageGO:001991510.015
positive regulation of cell cycleGO:004578730.015
negative regulation of intracellular protein transportGO:009031730.015
negative regulation of tor signalingGO:003200720.015
lateral inhibitionGO:004633110.015
transmission of nerve impulseGO:0019226190.015
g2 dna damage checkpointGO:003157230.015
positive regulation of cell adhesionGO:004578510.015
regulation of anatomical structure morphogenesisGO:00226031300.015
ameboidal type cell migrationGO:00016671430.015
tube morphogenesisGO:00352393490.015
tissue remodelingGO:004877140.015
positive regulation of cytokine productionGO:000181920.015
protein polymerizationGO:005125840.015
negative regulation of nucleocytoplasmic transportGO:004682320.015
post embryonic organ developmentGO:004856940.015
digestive system developmentGO:00551232890.015
viral processGO:001603210.015
symbiosis encompassing mutualism through parasitismGO:004440340.014
nuclear exportGO:005116810.014
regulation of biosynthetic processGO:00098892500.014
tube closureGO:006060610.014
stem cell fate commitmentGO:004886510.014
central nervous system developmentGO:00074173870.014
trabecula morphogenesisGO:006138320.014
membrane fusionGO:006102520.014
negative regulation of response to stimulusGO:00485851040.014
regulation of molecular functionGO:0065009700.014
negative regulation of sequestering of calcium ionGO:005128340.014
single organism organelle organizationGO:19025891990.014
regulation of metal ion transportGO:001095940.014
regulation of response to biotic stimulusGO:000283120.014
homeostatic processGO:00425921420.014
i kappab kinase nf kappab signalingGO:000724940.014
positive regulation of protein complex assemblyGO:003133420.014
cytosolic calcium ion transportGO:006040130.014
translational initiationGO:000641330.014
muscle cell developmentGO:00550011150.014
negative regulation of secretionGO:005104820.014
protein acylationGO:004354330.014
establishment of protein localization to plasma membraneGO:009000210.014
system processGO:00030081850.014
regulation of organ growthGO:004662030.014
positive regulation of cytosolic calcium ion concentrationGO:000720440.014
purine nucleoside monophosphate catabolic processGO:000912840.014
regulation of primary metabolic processGO:00800903110.014
protein polyubiquitinationGO:000020940.014
regulation of reproductive processGO:200024140.014
sensory organ morphogenesisGO:00905962000.014
er to golgi vesicle mediated transportGO:000688810.014
positive regulation of translationGO:004572710.014
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.013
cellular carbohydrate metabolic processGO:004426240.013
negative regulation of protein localization to nucleusGO:190018120.013
cytoskeleton organizationGO:0007010960.013
regulation of production of molecular mediator of immune responseGO:000270010.013
positive regulation of cytoskeleton organizationGO:005149530.013
single organism membrane fusionGO:004480120.013
actin polymerization or depolymerizationGO:000815420.013
positive regulation of leukocyte differentiationGO:190210710.013
chemotaxisGO:00069351040.013
regulation of calcium ion transportGO:005192420.013
positive regulation of nitrogen compound metabolic processGO:0051173690.013
neuron neuron synaptic transmissionGO:000727010.013
trabecula formationGO:006034320.013
positive regulation of ras protein signal transductionGO:004657910.013
lamellipodium assemblyGO:003003210.013
cytoplasm organizationGO:000702840.013
cellular protein metabolic processGO:00442671290.013
determination of left right symmetryGO:00073681790.013
posterior lateral line nerve developmentGO:004891880.013
regulation of cell developmentGO:00602841000.013
negative regulation of intracellular transportGO:003238730.013
actin filament polymerizationGO:003004120.013
regulation of protein complex disassemblyGO:004324410.013
regulation of apoptotic processGO:0042981980.013
spermatid developmentGO:000728620.013
organic substance transportGO:0071702580.013
Human Mouse
synaptic growth at neuromuscular junctionGO:005112420.013
membrane invaginationGO:001032410.013
positive regulation of epithelial cell proliferationGO:005067910.013
mechanosensory lateral line system developmentGO:0048881490.013
regulation of rna metabolic processGO:00512522240.013
macromolecule biosynthetic processGO:00090592270.013
regulation of mrna processingGO:005068430.013
hormone secretionGO:004687920.013
epithelial tube morphogenesisGO:00605621480.013
spindle assemblyGO:005122520.013
peptidyl lysine acetylationGO:001839420.013
regulation of microtubule cytoskeleton organizationGO:007050730.012
protein modification processGO:00362111000.012
negative regulation of mapk cascadeGO:004340940.012
response to endogenous stimulusGO:0009719830.012
segment polarity determinationGO:000736710.012
mitochondrial transportGO:000683920.012
positive regulation of dna metabolic processGO:005105410.012
secondary metabolic processGO:001974830.012
protein acetylationGO:000647320.012
regulation of cell differentiationGO:00455951420.012
regulation of neurotransmitter secretionGO:004692810.012
antimicrobial humoral responseGO:001973020.012
negative regulation of signalingGO:0023057960.012
carbohydrate derivative metabolic processGO:1901135610.012
peptide metabolic processGO:000651810.012
cation transmembrane transportGO:0098655650.012
sensory perception of chemical stimulusGO:000760630.012
cellular component assemblyGO:00226071700.012
double strand break repairGO:000630230.012
digestive tract developmentGO:00485652650.012
regulation of mrna splicing via spliceosomeGO:004802430.012
carbohydrate homeostasisGO:003350010.012
ras protein signal transductionGO:000726570.012
endoplasmic reticulum unfolded protein responseGO:003096820.012
positive regulation of macromolecule metabolic processGO:0010604930.012
sensory system developmentGO:0048880760.012
g2 m transition of mitotic cell cycleGO:000008640.012
regulation of i kappab kinase nf kappab signalingGO:004312240.012
negative regulation of leukocyte differentiationGO:190210610.012
interspecies interaction between organismsGO:004441940.012
cellular response to organic substanceGO:00713101050.012
regulation of nervous system developmentGO:0051960900.012
negative regulation of map kinase activityGO:004340720.012
synaptic vesicle recyclingGO:003646510.012
localization of cellGO:00516742440.012
regulation of striated muscle contractionGO:000694220.012
internal peptidyl lysine acetylationGO:001839320.012
positive regulation of immune effector processGO:000269930.012
regulation of macromolecule biosynthetic processGO:00105562250.012
phagocytosis engulfmentGO:000691110.012
regulation of alternative mrna splicing via spliceosomeGO:000038110.012
leukocyte homeostasisGO:000177620.011
release of sequestered calcium ion into cytosolGO:005120930.011
positive regulation of cell substrate adhesionGO:001081110.011
lamellipodium organizationGO:009758110.011
glial cell proliferationGO:001400940.011
polarized epithelial cell differentiationGO:003085940.011
regulation of membrane potentialGO:0042391230.011
positive regulation of multi organism processGO:004390230.011
eye developmentGO:00016542770.011
protein depolymerizationGO:005126110.011
golgi organizationGO:000703010.011
macromolecule modificationGO:00434121110.011
regulation of dendrite morphogenesisGO:004881430.011
melanin metabolic processGO:000658220.011
regulation of ras gtpase activityGO:003231820.011
regulation of cellular component organizationGO:0051128860.011
negative regulation of ras protein signal transductionGO:004658010.011
negative regulation of cell communicationGO:0010648960.011
small gtpase mediated signal transductionGO:000726480.011
cellular response to radiationGO:007147840.011
regulation of glucose transportGO:001082710.011
developmental pigmentationGO:0048066480.011
cellular response to topologically incorrect proteinGO:003596720.011
glucose importGO:004632320.011
regulation of jak stat cascadeGO:004642530.011
regulation of neural precursor cell proliferationGO:200017730.011
single organismal cell cell adhesionGO:0016337290.011
regulation of exocytosisGO:001715710.011
negative regulation of developmental processGO:0051093650.011
actin filament based movementGO:003004810.011
determination of heart left right asymmetryGO:00613711170.011
regulation of rho protein signal transductionGO:003502320.011
protein dephosphorylationGO:000647030.011
negative regulation of synapse assemblyGO:005196420.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.011
cellular protein complex disassemblyGO:004362410.011
digestive tract morphogenesisGO:00485462310.011
actin cytoskeleton organizationGO:0030036630.011
skeletal muscle organ developmentGO:0060538780.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.011
regulation of nucleic acid templated transcriptionGO:19035062130.011
mitotic g2 m transition checkpointGO:004481830.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.011
axis specificationGO:0009798430.011
negative regulation of signal transductionGO:0009968940.011
regulation of carbohydrate metabolic processGO:000610940.011
positive regulation of cellular metabolic processGO:0031325940.011
negative regulation of metabolic processGO:0009892860.010
regulation of hormone secretionGO:004688320.010
ensheathment of neuronsGO:0007272180.010
centrosome cycleGO:000709810.010
b cell activationGO:004211320.010
post golgi vesicle mediated transportGO:000689210.010
negative regulation of protein serine threonine kinase activityGO:007190120.010
peptidyl threonine modificationGO:001821010.010
cellular protein modification processGO:00064641000.010
multi organism cellular processGO:004476420.010
regulation of extrinsic apoptotic signaling pathwayGO:200123630.010
embryonic heart tube morphogenesisGO:00031431080.010
gliogenesisGO:0042063450.010
pigment granule localizationGO:0051875250.010
negative regulation of multi organism processGO:004390130.010

sec63 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.051
nervous system diseaseDOID:86300.029
musculoskeletal system diseaseDOID:1700.024
disease of cellular proliferationDOID:1456600.022
organ system cancerDOID:005068600.022
cancerDOID:16200.022
cardiovascular system diseaseDOID:128700.018
muscular diseaseDOID:008000000.015
myopathyDOID:42300.015
muscle tissue diseaseDOID:6600.015
central nervous system diseaseDOID:33100.011
brain diseaseDOID:93600.011
disease of metabolismDOID:001466700.010