IMP: Integrative Multi-species Prediction

Danio rerio

13 known processes

evx1

even-skipped homeobox 1

(Aliases: evx-1,cb416)

ZFIN: ZDB-GENE-980526-364
Entrez: 30499
Ensembl: ENSDARG00000005628
UniProtKB: Q1L975
UniProtKB: Q9DD27

Process Predictions
Disease Predictions

evx1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of nucleic acid templated transcription	GO:1903506	213	0.982	Mouse
cellular macromolecule metabolic process	GO:0044260	391	0.976	Mouse
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.974	Mouse
regulation of macromolecule metabolic process	GO:0060255	317	0.972	Mouse
cellular macromolecule biosynthetic process	GO:0034645	224	0.969	Mouse
regulation of gene expression	GO:0010468	265	0.966	Mouse
positive regulation of cellular process	GO:0048522	201	0.965	Mouse
cellular biosynthetic process	GO:0044249	286	0.961	Mouse
biosynthetic process	GO:0009058	294	0.951	Mouse
macromolecule biosynthetic process	GO:0009059	227	0.949	Mouse
organic substance biosynthetic process	GO:1901576	289	0.947	Mouse
regulation of rna metabolic process	GO:0051252	224	0.936	Mouse
axonogenesis	GO:0007409	152	0.931
regulation of cellular metabolic process	GO:0031323	320	0.928	Mouse
blood vessel morphogenesis	GO:0048514	216	0.925
blood vessel development	GO:0001568	246	0.922
heterocycle metabolic process	GO:0046483	290	0.913	Mouse
signal transduction	GO:0007165	455	0.913
cell morphogenesis involved in differentiation	GO:0000904	195	0.913
neuron fate specification	GO:0048665	20	0.908	Mouse
nucleic acid templated transcription	GO:0097659	181	0.907	Mouse
regulation of macromolecule biosynthetic process	GO:0010556	225	0.903	Mouse
organic cyclic compound metabolic process	GO:1901360	301	0.892	Mouse
digestive tract development	GO:0048565	265	0.890	Zebrafish
regulation of rna biosynthetic process	GO:2001141	213	0.888	Mouse
rna metabolic process	GO:0016070	219	0.886	Mouse
septum transversum development	GO:0003343	4	0.877
positive regulation of biological process	GO:0048518	253	0.876	Mouse
nitrogen compound metabolic process	GO:0006807	319	0.875	Mouse
cellular aromatic compound metabolic process	GO:0006725	295	0.872	Mouse
neuron projection morphogenesis	GO:0048812	161	0.871
cell part morphogenesis	GO:0032990	246	0.868
regionalization	GO:0003002	274	0.866	Zebrafish Mouse
nucleobase containing compound metabolic process	GO:0006139	274	0.864	Mouse
regulation of metabolic process	GO:0019222	359	0.860	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	93	0.855	Mouse
regulation of signaling	GO:0023051	235	0.853
regulation of cellular biosynthetic process	GO:0031326	245	0.851	Mouse
neuron fate commitment	GO:0048663	26	0.834	Mouse
fin regeneration	GO:0031101	51	0.820
negative regulation of biological process	GO:0048519	304	0.818
gland development	GO:0048732	143	0.809
anterior posterior axon guidance	GO:0033564	5	0.808
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.801	Mouse
brain development	GO:0007420	293	0.799
regulation of nitrogen compound metabolic process	GO:0051171	251	0.798	Mouse
regulation of primary metabolic process	GO:0080090	311	0.795	Mouse
cell projection organization	GO:0030030	284	0.795
regulation of cellular protein metabolic process	GO:0032268	52	0.785
apoptotic process	GO:0006915	116	0.771
single organism metabolic process	GO:0044710	217	0.764
tissue regeneration	GO:0042246	74	0.761
nucleic acid metabolic process	GO:0090304	244	0.760	Mouse
digestive tract morphogenesis	GO:0048546	231	0.757	Zebrafish
central nervous system projection neuron axonogenesis	GO:0021952	15	0.754
cellular nitrogen compound metabolic process	GO:0034641	290	0.750	Mouse
regulation of transcription dna templated	GO:0006355	213	0.729	Mouse
regeneration	GO:0031099	91	0.727
positive regulation of metabolic process	GO:0009893	108	0.726	Mouse
central nervous system development	GO:0007417	387	0.724	Mouse
neuron projection guidance	GO:0097485	86	0.715
regulation of biosynthetic process	GO:0009889	250	0.701	Mouse
rna biosynthetic process	GO:0032774	181	0.700	Mouse
olfactory bulb development	GO:0021772	4	0.700
regulation of organ morphogenesis	GO:2000027	35	0.697	Zebrafish
growth	GO:0040007	174	0.691
response to stress	GO:0006950	263	0.681
female sex differentiation	GO:0046660	4	0.680
gene expression	GO:0010467	252	0.679	Mouse
positive regulation of cellular metabolic process	GO:0031325	94	0.672	Mouse
aromatic compound biosynthetic process	GO:0019438	217	0.671	Mouse
heart morphogenesis	GO:0003007	156	0.666
vasculature development	GO:0001944	278	0.662
cell fate specification	GO:0001708	68	0.661	Zebrafish Mouse
cellular component morphogenesis	GO:0032989	336	0.645
positive regulation of signaling	GO:0023056	56	0.640
neuron development	GO:0048666	262	0.634
axon guidance	GO:0007411	86	0.632
single organism localization	GO:1902578	225	0.632
regulation of signal transduction	GO:0009966	225	0.621
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.615	Zebrafish
appendage development	GO:0048736	80	0.613
heart jogging	GO:0003146	40	0.603
positive regulation of response to stimulus	GO:0048584	80	0.602
heterocycle biosynthetic process	GO:0018130	215	0.599	Mouse
positive regulation of gene expression	GO:0010628	71	0.591	Mouse
embryonic limb morphogenesis	GO:0030326	2	0.582
cell projection morphogenesis	GO:0048858	244	0.581
nucleobase containing compound biosynthetic process	GO:0034654	205	0.576	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	68	0.575	Mouse
reproductive process	GO:0022414	40	0.568
response to external stimulus	GO:0009605	264	0.566
central nervous system neuron development	GO:0021954	29	0.566
developmental growth	GO:0048589	166	0.564
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.558	Mouse
organic cyclic compound biosynthetic process	GO:1901362	223	0.556	Mouse
transcription dna templated	GO:0006351	181	0.552	Mouse
spinal cord development	GO:0021510	46	0.546	Mouse
cellular component movement	GO:0006928	335	0.540
appendage morphogenesis	GO:0035107	56	0.540
response to chemical	GO:0042221	320	0.538
regulation of cell death	GO:0010941	103	0.534
camera type eye morphogenesis	GO:0048593	108	0.533
programmed cell death	GO:0012501	119	0.530
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.529	Mouse
regulation of apoptotic process	GO:0042981	98	0.527
protein metabolic process	GO:0019538	183	0.526
mesoderm formation	GO:0001707	43	0.520	Zebrafish
system process	GO:0003008	185	0.515
central nervous system neuron differentiation	GO:0021953	74	0.506	Mouse
sensory organ morphogenesis	GO:0090596	200	0.501
exocrine system development	GO:0035272	28	0.500
positive regulation of cell death	GO:0010942	29	0.499
amine metabolic process	GO:0009308	2	0.498
ubiquitin dependent protein catabolic process	GO:0006511	3	0.495
negative regulation of axonogenesis	GO:0050771	7	0.486
positive regulation of transcription dna templated	GO:0045893	57	0.483	Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.482
wound healing	GO:0042060	90	0.481
response to wounding	GO:0009611	116	0.477
gabaergic neuron differentiation	GO:0097154	2	0.476
pancreas development	GO:0031016	84	0.472
neuroblast differentiation	GO:0014016	1	0.465
axon development	GO:0061564	166	0.456
glial cell migration	GO:0008347	3	0.452
erk1 and erk2 cascade	GO:0070371	4	0.452
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	2	0.447
regulation of programmed cell death	GO:0043067	101	0.443
death	GO:0016265	121	0.436
gastrulation	GO:0007369	208	0.435	Zebrafish
regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901213	15	0.435
ventral spinal cord development	GO:0021517	35	0.433	Mouse
mesoderm development	GO:0007498	88	0.427	Zebrafish
morphogenesis of an epithelium	GO:0002009	333	0.426
macromolecule modification	GO:0043412	111	0.423
larval development	GO:0002164	2	0.418
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.417	Mouse
cell morphogenesis	GO:0000902	289	0.410
negative regulation of apoptotic process	GO:0043066	55	0.407
sensory organ development	GO:0007423	393	0.398
motor neuron axon guidance	GO:0008045	23	0.397
axon extension	GO:0048675	45	0.395
neuron projection development	GO:0031175	180	0.378
olfactory lobe development	GO:0021988	4	0.370
regulation of dna replication	GO:0006275	3	0.369
transcription from rna polymerase ii promoter	GO:0006366	80	0.369	Mouse
type b pancreatic cell development	GO:0003323	4	0.368
columnar cuboidal epithelial cell differentiation	GO:0002065	38	0.363
apoptotic process involved in morphogenesis	GO:0060561	2	0.362
embryonic organ development	GO:0048568	381	0.360
negative regulation of cellular process	GO:0048523	283	0.358
positive regulation of neurogenesis	GO:0050769	24	0.357
cell maturation	GO:0048469	23	0.350
positive regulation of biosynthetic process	GO:0009891	68	0.333	Mouse
enteroendocrine cell differentiation	GO:0035883	9	0.333
regulation of embryonic development	GO:0045995	47	0.328	Zebrafish
cell death	GO:0008219	121	0.322
regulation of biological quality	GO:0065008	263	0.321
embryonic skeletal joint development	GO:0072498	3	0.320
endocrine pancreas development	GO:0031018	27	0.319
regulation of developmental process	GO:0050793	247	0.316	Zebrafish
peripheral nervous system neuron differentiation	GO:0048934	28	0.315
heart development	GO:0007507	313	0.314
negative regulation of multicellular organismal process	GO:0051241	69	0.313
cardiogenic plate morphogenesis	GO:0003142	1	0.310
skeletal system development	GO:0001501	181	0.304
cellular protein metabolic process	GO:0044267	129	0.296
positive regulation of nervous system development	GO:0051962	25	0.293
cellular protein modification process	GO:0006464	100	0.291
establishment of localization	GO:0051234	244	0.289
polarized epithelial cell differentiation	GO:0030859	4	0.276
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.275	Mouse
eye development	GO:0001654	277	0.275
cell growth	GO:0016049	57	0.272
locomotory behavior	GO:0007626	34	0.271
regulation of cell communication	GO:0010646	232	0.269
intracellular signal transduction	GO:0035556	85	0.269
multi organism process	GO:0051704	134	0.266
chemotaxis	GO:0006935	104	0.266
regulation of cellular component organization	GO:0051128	86	0.260
artery development	GO:0060840	22	0.260
positive regulation of rna metabolic process	GO:0051254	59	0.258	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.257	Mouse
neuron differentiation	GO:0030182	353	0.256	Mouse
regulation of erk1 and erk2 cascade	GO:0070372	4	0.246
single organism reproductive process	GO:0044702	40	0.245
digestive system development	GO:0055123	289	0.245	Zebrafish
endocrine system development	GO:0035270	65	0.244
embryonic heart tube formation	GO:0003144	1	0.240
retinal ganglion cell axon guidance	GO:0031290	35	0.239
negative regulation of biosynthetic process	GO:0009890	55	0.239
positive regulation of cell development	GO:0010720	25	0.239
nephron tubule morphogenesis	GO:0072078	1	0.234
mesoderm morphogenesis	GO:0048332	51	0.233	Zebrafish
negative regulation of gene expression	GO:0010629	65	0.232
negative regulation of developmental process	GO:0051093	65	0.230
epithelial cell differentiation	GO:0030855	116	0.228
phosphorus metabolic process	GO:0006793	109	0.227
cell cycle process	GO:0022402	53	0.221
developmental growth involved in morphogenesis	GO:0060560	86	0.221
developmental programmed cell death	GO:0010623	4	0.219
phosphorylation	GO:0016310	69	0.215
positive regulation of epithelial cell differentiation	GO:0030858	2	0.214
hindbrain development	GO:0030902	91	0.214
cell fate specification involved in pattern specification	GO:0060573	3	0.213	Mouse
negative regulation of response to stimulus	GO:0048585	104	0.210
heart contraction	GO:0060047	71	0.207
angiogenesis	GO:0001525	158	0.206
nephron epithelium morphogenesis	GO:0072088	1	0.205
regulation of axon extension	GO:0030516	24	0.204
behavior	GO:0007610	74	0.203
pancreatic a cell development	GO:0003322	2	0.203
development of primary female sexual characteristics	GO:0046545	4	0.201
regulation of response to stimulus	GO:0048583	269	0.200
positive regulation of protein kinase b signaling	GO:0051897	1	0.200
cell cycle	GO:0007049	93	0.198
regulation of protein metabolic process	GO:0051246	56	0.197
renal system development	GO:0072001	94	0.196
negative regulation of axon extension	GO:0030517	7	0.196
cardioblast migration to the midline involved in heart field formation	GO:0060975	7	0.195
positive regulation of cellular protein metabolic process	GO:0032270	22	0.195
axonal fasciculation	GO:0007413	11	0.192
taxis	GO:0042330	109	0.191
apoptotic process involved in development	GO:1902742	2	0.188
positive regulation of developmental process	GO:0051094	50	0.187
apoptotic signaling pathway	GO:0097190	23	0.185
central nervous system neuron axonogenesis	GO:0021955	18	0.183
regulation of dna metabolic process	GO:0051052	11	0.183
fin development	GO:0033333	77	0.182
body morphogenesis	GO:0010171	16	0.180	Worm
auditory receptor cell fate determination	GO:0042668	2	0.179
regulation of stem cell differentiation	GO:2000736	4	0.176
protein acylation	GO:0043543	3	0.174
phosphate containing compound metabolic process	GO:0006796	108	0.173
photoreceptor cell fate commitment	GO:0046552	1	0.172
skeletal system morphogenesis	GO:0048705	102	0.172
striated muscle cell differentiation	GO:0051146	129	0.172
pancreatic d cell differentiation	GO:0003311	2	0.170
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.170
regulation of cell fate specification	GO:0042659	20	0.166	Zebrafish
muscle organ development	GO:0007517	101	0.166
organ formation	GO:0048645	17	0.166
eye morphogenesis	GO:0048592	144	0.165
fin morphogenesis	GO:0033334	53	0.165
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.165
endodermal cell fate specification	GO:0001714	17	0.164
negative regulation of cellular biosynthetic process	GO:0031327	55	0.163
artery morphogenesis	GO:0048844	14	0.162
internal peptidyl lysine acetylation	GO:0018393	2	0.162
dna metabolic process	GO:0006259	27	0.161
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.161	Mouse
cell cell signaling	GO:0007267	52	0.161
tube morphogenesis	GO:0035239	349	0.160	Zebrafish
telencephalon development	GO:0021537	14	0.159
neural retina development	GO:0003407	49	0.159
formation of primary germ layer	GO:0001704	62	0.157	Zebrafish
blood circulation	GO:0008015	87	0.157
heart formation	GO:0060914	13	0.156
oocyte development	GO:0048599	14	0.155
macromolecular complex subunit organization	GO:0043933	74	0.154
epithelial cell development	GO:0002064	42	0.149
cell fate commitment	GO:0045165	99	0.149	Zebrafish Mouse
transport	GO:0006810	220	0.148
proepicardium development	GO:0003342	4	0.147
ear morphogenesis	GO:0042471	64	0.146
specification of symmetry	GO:0009799	204	0.146
retina development in camera type eye	GO:0060041	146	0.145
cognition	GO:0050890	1	0.145
negative regulation of axon guidance	GO:1902668	1	0.143
chordate embryonic development	GO:0043009	271	0.143
regulation of protein maturation	GO:1903317	10	0.142
negative regulation of transcription dna templated	GO:0045892	45	0.142
modification dependent macromolecule catabolic process	GO:0043632	3	0.142
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.141
developmental process involved in reproduction	GO:0003006	27	0.141
anterior posterior pattern specification	GO:0009952	152	0.140
negative regulation of cell growth	GO:0030308	7	0.139
cellular protein catabolic process	GO:0044257	4	0.139
negative regulation of cell communication	GO:0010648	96	0.139
regulation of multicellular organismal development	GO:2000026	223	0.138	Zebrafish
renal tubule morphogenesis	GO:0061333	1	0.137
embryonic heart tube morphogenesis	GO:0003143	108	0.137
regulation of reproductive process	GO:2000241	4	0.136
dorsal ventral pattern formation	GO:0009953	125	0.135	Zebrafish Mouse
rhythmic process	GO:0048511	21	0.134
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	1	0.133
inner ear development	GO:0048839	126	0.133
signal transduction in absence of ligand	GO:0038034	1	0.133
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.133
negative regulation of signal transduction in absence of ligand	GO:1901099	1	0.132
cellular response to growth factor stimulus	GO:0071363	39	0.126
cardiac chamber development	GO:0003205	19	0.126
protein modification process	GO:0036211	100	0.126
microtubule based process	GO:0007017	60	0.124
heart process	GO:0003015	71	0.122
limb morphogenesis	GO:0035108	7	0.122
carboxylic acid metabolic process	GO:0019752	22	0.121
spinal cord motor neuron differentiation	GO:0021522	26	0.120
negative regulation of rna biosynthetic process	GO:1902679	45	0.120
thyroid gland development	GO:0030878	12	0.118
cellular component assembly	GO:0022607	170	0.118
regulation of intracellular signal transduction	GO:1902531	57	0.118
response to abiotic stimulus	GO:0009628	122	0.117
regulation of protein modification process	GO:0031399	29	0.116
kidney development	GO:0001822	92	0.115
hemangioblast cell differentiation	GO:0060217	5	0.115
positive regulation of neuron differentiation	GO:0045666	12	0.115
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.115
cell motility	GO:0048870	244	0.114
positive regulation of multicellular organismal process	GO:0051240	52	0.114
positive regulation of cell differentiation	GO:0045597	30	0.114
negative regulation of reproductive process	GO:2000242	3	0.113
developmental maturation	GO:0021700	34	0.112
gliogenesis	GO:0042063	45	0.112
synapse assembly	GO:0007416	9	0.112
urogenital system development	GO:0001655	97	0.109
mesodermal cell differentiation	GO:0048333	21	0.108	Zebrafish
regulation of cell cycle	GO:0051726	52	0.107
protein complex subunit organization	GO:0071822	46	0.106
eye photoreceptor cell development	GO:0042462	30	0.106
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.105
negative regulation of macromolecule metabolic process	GO:0010605	76	0.105
peripheral nervous system development	GO:0007422	55	0.105
single organism transport	GO:0044765	206	0.104
positive regulation of cell proliferation	GO:0008284	15	0.104
pericardium development	GO:0060039	1	0.104
embryonic organ morphogenesis	GO:0048562	274	0.103
regulation of epithelial cell proliferation	GO:0050678	3	0.102
regulation of mesoderm development	GO:2000380	11	0.102	Zebrafish
proximal distal pattern formation	GO:0009954	1	0.101
cellular ketone metabolic process	GO:0042180	11	0.101
cardiocyte differentiation	GO:0035051	44	0.101
regulation of neurogenesis	GO:0050767	87	0.101
negative regulation of metabolic process	GO:0009892	86	0.101
regulation of multicellular organismal process	GO:0051239	277	0.100	Zebrafish
generation of neurons	GO:0048699	385	0.100	Mouse
primitive hemopoiesis	GO:0060215	27	0.100
forebrain development	GO:0030900	96	0.100
cellular amino acid metabolic process	GO:0006520	7	0.100
regulation of blood circulation	GO:1903522	32	0.099
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.099
regulation of meiotic cell cycle	GO:0051445	1	0.098
negative regulation of signal transduction	GO:0009968	94	0.098
negative regulation of cellular metabolic process	GO:0031324	77	0.098
columnar cuboidal epithelial cell development	GO:0002066	5	0.098
regulation of endothelial cell differentiation	GO:0045601	3	0.098
head development	GO:0060322	303	0.097
neuron neuron synaptic transmission	GO:0007270	1	0.097
specification of organ identity	GO:0010092	2	0.097
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.096
neuron projection regeneration	GO:0031102	16	0.096
embryonic heart tube development	GO:0035050	133	0.096
regulation of synapse assembly	GO:0051963	3	0.096
nephron morphogenesis	GO:0072028	2	0.096
epidermis development	GO:0008544	48	0.095
pancreatic d cell development	GO:0003324	1	0.095
cardiac muscle cell differentiation	GO:0055007	30	0.094
germ line stem cell maintenance	GO:0030718	2	0.094
endothelial cell proliferation	GO:0001935	11	0.094
establishment of localization in cell	GO:0051649	77	0.093
cellular localization	GO:0051641	97	0.093
cell proliferation	GO:0008283	80	0.093
neuron recognition	GO:0008038	18	0.092
developmental cell growth	GO:0048588	52	0.092
vasculogenesis	GO:0001570	41	0.091
embryonic appendage morphogenesis	GO:0035113	30	0.091
regulation of mesodermal cell fate specification	GO:0042661	9	0.090	Zebrafish
diencephalon development	GO:0021536	58	0.090
regulation of anatomical structure morphogenesis	GO:0022603	130	0.090	Zebrafish
negative regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043154	7	0.089
regulation of localization	GO:0032879	104	0.089
camera type eye development	GO:0043010	222	0.089
response to decreased oxygen levels	GO:0036293	25	0.089
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.087
rhombomere development	GO:0021546	19	0.086
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.086
negative regulation of programmed cell death	GO:0043069	58	0.085
ameboidal type cell migration	GO:0001667	143	0.085
inner ear morphogenesis	GO:0042472	63	0.085
regulation of circadian rhythm	GO:0042752	4	0.085
cellular component biogenesis	GO:0044085	178	0.084
negative regulation of neuron projection development	GO:0010977	9	0.083
modification dependent protein catabolic process	GO:0019941	3	0.083
regulation of cell proliferation	GO:0042127	37	0.082
axon regeneration	GO:0031103	14	0.082
regulation of protein ubiquitination	GO:0031396	3	0.082
anterior commissure morphogenesis	GO:0021960	3	0.081
ventral spinal cord interneuron fate commitment	GO:0060579	3	0.081	Mouse
regulation of cell growth	GO:0001558	29	0.080
negative regulation of cysteine type endopeptidase activity	GO:2000117	8	0.080
phenol containing compound biosynthetic process	GO:0046189	4	0.079
dendrite morphogenesis	GO:0048813	5	0.079
rhombomere morphogenesis	GO:0021593	17	0.079
cell cell signaling involved in cell fate commitment	GO:0045168	12	0.078
cell surface receptor signaling pathway	GO:0007166	325	0.078
positive regulation of endothelial cell differentiation	GO:0045603	2	0.078
formation of anatomical boundary	GO:0048859	14	0.078
small molecule metabolic process	GO:0044281	77	0.078
axon midline choice point recognition	GO:0016199	4	0.078
auditory receptor cell differentiation	GO:0042491	15	0.076
positive regulation of molecular function	GO:0044093	33	0.076
posterior lateral line system development	GO:0048915	46	0.075
chromosome organization	GO:0051276	31	0.075
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	2	0.074
cell migration	GO:0016477	237	0.074
glandular epithelial cell differentiation	GO:0002067	9	0.074
organic acid metabolic process	GO:0006082	31	0.073
anterior lateral line nerve development	GO:0048909	4	0.073
reproduction	GO:0000003	40	0.073
response to carbohydrate	GO:0009743	3	0.073
metencephalon development	GO:0022037	27	0.072
adult behavior	GO:0030534	2	0.072
determination of left right symmetry	GO:0007368	179	0.072
protein import	GO:0017038	3	0.072
pharyngeal muscle development	GO:0043282	4	0.071
bmp signaling pathway involved in determination of left right symmetry	GO:0003154	14	0.071
positive regulation of rna biosynthetic process	GO:1902680	57	0.070	Mouse
pronephric glomerulus morphogenesis	GO:0035775	6	0.070
negative regulation of signaling	GO:0023057	96	0.070
embryonic skeletal system morphogenesis	GO:0048704	93	0.070
ventricular cardiac muscle cell development	GO:0055015	5	0.070
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.069
neurological system process	GO:0050877	62	0.068
retina layer formation	GO:0010842	24	0.067
aging	GO:0007568	2	0.067
bmp signaling pathway	GO:0030509	52	0.067
cellular response to organic substance	GO:0071310	105	0.066
regulation of phosphorylation	GO:0042325	26	0.066
mesodermal cell migration	GO:0008078	12	0.065
cardioblast differentiation	GO:0010002	9	0.065
organelle fission	GO:0048285	23	0.065
establishment or maintenance of cell polarity	GO:0007163	29	0.065
negative regulation of axon extension involved in axon guidance	GO:0048843	1	0.065
multicellular organism reproduction	GO:0032504	35	0.064
positive regulation of endothelial cell proliferation	GO:0001938	1	0.064
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.064	Mouse
type b pancreatic cell differentiation	GO:0003309	8	0.063
cellular response to stress	GO:0033554	62	0.062
regulation of cellular amino acid metabolic process	GO:0006521	0	0.062
negative regulation of cell differentiation	GO:0045596	46	0.061
response to alcohol	GO:0097305	14	0.061
negative regulation of cell death	GO:0060548	60	0.061
negative regulation of rna metabolic process	GO:0051253	48	0.060
post embryonic morphogenesis	GO:0009886	4	0.060
morphogenesis of embryonic epithelium	GO:0016331	30	0.059
nuclear division	GO:0000280	23	0.059
nuclear transport	GO:0051169	4	0.057
internal protein amino acid acetylation	GO:0006475	2	0.057
regulation of endodermal cell fate specification	GO:0042663	15	0.057
determination of intestine left right asymmetry	GO:0071908	2	0.057
cardioblast migration	GO:0003260	7	0.056
cell substrate adhesion	GO:0031589	4	0.056
lipid catabolic process	GO:0016042	4	0.055
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	1	0.054
muscle cell differentiation	GO:0042692	139	0.054
single organism cell adhesion	GO:0098602	29	0.054
epithelial tube morphogenesis	GO:0060562	148	0.054
determination of bilateral symmetry	GO:0009855	204	0.054
negative regulation of chromatin modification	GO:1903309	1	0.053
organonitrogen compound metabolic process	GO:1901564	74	0.053
organelle organization	GO:0006996	227	0.053
regulation of cell development	GO:0060284	100	0.053
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.053
stem cell maintenance	GO:0019827	4	0.053
female gonad development	GO:0008585	4	0.052
dendrite guidance	GO:0070983	0	0.052
notochord development	GO:0030903	54	0.052
vestibular receptor cell development	GO:0060118	3	0.052
multicellular organism growth	GO:0035264	4	0.052
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.051
peptidyl lysine acetylation	GO:0018394	2	0.051
embryo development ending in birth or egg hatching	GO:0009792	271	0.051	Mouse Worm
mesenchyme development	GO:0060485	127	0.051
meiotic nuclear division	GO:0007126	4	0.051
photoreceptor cell development	GO:0042461	40	0.050
regulation of proteolysis	GO:0030162	24	0.050
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	1	0.050
determination of heart left right asymmetry	GO:0061371	117	0.050
positive regulation of transport	GO:0051050	2	0.050
response to organic substance	GO:0010033	153	0.050
cellular amine metabolic process	GO:0044106	2	0.049
reproductive structure development	GO:0048608	5	0.049
axonal defasciculation	GO:0007414	2	0.049
determination of dorsal ventral asymmetry	GO:0048262	34	0.049
response to endogenous stimulus	GO:0009719	83	0.048
positive regulation of map kinase activity	GO:0043406	3	0.048
catecholamine biosynthetic process	GO:0042423	2	0.048
facial nucleus development	GO:0021754	7	0.048
embryonic camera type eye development	GO:0031076	29	0.048
embryonic axis specification	GO:0000578	12	0.048

evx1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.313
musculoskeletal system disease	DOID:17	0.152
bone development disease	DOID:0080006	0.130
bone disease	DOID:0080001	0.130
connective tissue disease	DOID:65	0.130
dysostosis	DOID:1934	0.070

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