Danio rerio

9 known processes

traf3

TNF receptor-associated factor 3

(Aliases: zgc:92367)

traf3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.080
agingGO:000756820.069
protein import into nucleusGO:000660630.064
regulation of establishment of protein localizationGO:007020140.062
protein targeting to nucleusGO:004474430.053
protein localization to nucleusGO:003450430.052
establishment of protein localization to organelleGO:007259440.049
regulation of protein localization to nucleusGO:190018020.047
nitrogen compound metabolic processGO:00068073190.044
Human Zebrafish Mouse
regulation of protein transportGO:005122330.044
single organism nuclear importGO:190259330.043
regulation of protein targetingGO:190353320.043
negative regulation of protein transportGO:005122430.043
organic cyclic compound metabolic processGO:19013603010.042
Human Zebrafish Mouse
nuclear transportGO:005116940.042
cellular nitrogen compound metabolic processGO:00346412900.042
Human Zebrafish Mouse
cell projection organizationGO:00300302840.042
nucleobase containing compound metabolic processGO:00061392740.041
Human Zebrafish Mouse
nuclear importGO:005117030.041
cellular response to extracellular stimulusGO:003166820.040
nucleocytoplasmic transportGO:000691340.039
positive regulation of transportGO:005105020.039
cell projection morphogenesisGO:00488582440.038
autophagyGO:000691440.038
heterocycle metabolic processGO:00464832900.038
Human Zebrafish Mouse
amine metabolic processGO:000930820.038
regulation of intracellular protein transportGO:003315730.037
response to nutrientGO:000758430.037
cellular macromolecule metabolic processGO:00442603910.037
Human Zebrafish Mouse
regulation of protein import into nucleusGO:004230620.037
morphogenesis of an epitheliumGO:00020093330.037
cellular response to nutrient levelsGO:003166920.036
cell morphogenesisGO:00009022890.036
positive regulation of cell cycleGO:004578730.036
maintenance of locationGO:005123540.036
phagocytosisGO:000690930.035
positive regulation of cellular component biogenesisGO:004408930.035
mononuclear cell proliferationGO:003294310.035
cellular response to external stimulusGO:007149620.035
protein importGO:001703830.034
organic substance biosynthetic processGO:19015762890.034
Human Zebrafish Mouse
cellular biosynthetic processGO:00442492860.034
Human Zebrafish Mouse
gtp metabolic processGO:004603940.034
cellular amine metabolic processGO:004410620.033
response to drugGO:004249330.032
regulation of cellular metabolic processGO:00313233200.032
Human Zebrafish Mouse
cellular component biogenesisGO:00440851780.032
regulation of nitrogen compound metabolic processGO:00511712510.032
Human Zebrafish Mouse
multicellular organism growthGO:003526440.031
cell part morphogenesisGO:00329902460.031
macromolecule biosynthetic processGO:00090592270.031
Human Zebrafish Mouse
regulation of multicellular organism growthGO:004001440.031
regulation of nucleocytoplasmic transportGO:004682220.031
cellular response to starvationGO:000926710.031
regulation of rna metabolic processGO:00512522240.030
Human Zebrafish Mouse
organonitrogen compound metabolic processGO:1901564740.030
organic acid metabolic processGO:0006082310.030
carboxylic acid metabolic processGO:0019752220.029
regulation of cytoplasmic transportGO:190364940.029
regulation of cellular amino acid metabolic processGO:000652100.029
single organism organelle organizationGO:19025891990.029
sensory organ developmentGO:00074233930.029
negative regulation of cytoplasmic transportGO:190365020.028
biosynthetic processGO:00090582940.028
Human Zebrafish Mouse
gtp catabolic processGO:000618420.027
nucleic acid metabolic processGO:00903042440.027
Human Zebrafish Mouse
small molecule metabolic processGO:0044281770.027
cellular component morphogenesisGO:00329893360.027
guanosine containing compound catabolic processGO:190106920.027
positive regulation of cellular catabolic processGO:003133130.027
single organism localizationGO:19025782250.027
regulation of cell shapeGO:000836010.027
organelle organizationGO:00069962270.027
negative regulation of nucleocytoplasmic transportGO:004682320.027
heterocycle biosynthetic processGO:00181302150.026
Human Zebrafish Mouse
ribonucleoside monophosphate catabolic processGO:000915840.026
regulation of neural precursor cell proliferationGO:200017730.026
stem cell maintenanceGO:001982740.026
regulation of mrna processingGO:005068430.026
guanosine containing compound metabolic processGO:190106840.026
tube morphogenesisGO:00352393490.025
aromatic compound biosynthetic processGO:00194382170.025
Human Zebrafish Mouse
single organism metabolic processGO:00447102170.025
cellular nitrogen compound biosynthetic processGO:00442712180.025
Human Zebrafish Mouse
oxoacid metabolic processGO:0043436310.025
regionalizationGO:00030022740.025
positive regulation of catabolic processGO:000989640.025
lipid catabolic processGO:001604240.025
mitochondrion organizationGO:000700540.025
extrinsic apoptotic signaling pathwayGO:009719130.025
cytokinesisGO:000091030.025
cellular aromatic compound metabolic processGO:00067252950.024
Human Zebrafish Mouse
primary neural tube formationGO:001402010.024
regulation of cellular amine metabolic processGO:003323800.024
cell surface receptor signaling pathwayGO:00071663250.024
Human Mouse
cellular amide metabolic processGO:004360340.024
regulation of response to stimulusGO:00485832690.024
Mouse
central nervous system developmentGO:00074173870.024
specification of symmetryGO:00097992040.024
negative regulation of protein localization to nucleusGO:190018120.024
stem cell proliferationGO:007208940.024
regulation of protein complex assemblyGO:004325430.024
cognitionGO:005089010.024
internal protein amino acid acetylationGO:000647520.024
secondary metabolic processGO:001974830.023
signal transductionGO:00071654550.023
Human Mouse
female sex differentiationGO:004666040.023
macroautophagyGO:001623610.023
neuron differentiationGO:00301823530.023
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.023
positive regulation of cell adhesionGO:004578510.023
blood vessel developmentGO:00015682460.023
regulation of developmental processGO:00507932470.023
regulation of primary metabolic processGO:00800903110.023
Human Zebrafish Mouse
response to glucoseGO:000974930.023
i kappab kinase nf kappab signalingGO:000724940.023
rna metabolic processGO:00160702190.022
Human Zebrafish Mouse
regulation of cell activationGO:005086510.022
generation of neuronsGO:00486993850.022
cell substrate adhesionGO:003158940.022
regulation of multicellular organismal processGO:00512392770.022
Mouse
determination of bilateral symmetryGO:00098552040.022
heart developmentGO:00075073130.022
atp catabolic processGO:000620040.022
regulation of biological qualityGO:00650082630.022
response to monosaccharideGO:003428430.022
neuron projection developmentGO:00311751800.022
vasculature developmentGO:00019442780.022
regulation of production of molecular mediator of immune responseGO:000270010.022
regulation of transcription dna templatedGO:00063552130.022
Human Zebrafish Mouse
response to chemicalGO:00422213200.022
Human Mouse
negative regulation of intracellular transportGO:003238730.021
regulation of i kappab kinase nf kappab signalingGO:004312240.021
positive regulation of secretion by cellGO:190353210.021
regulation of response to biotic stimulusGO:000283120.021
Mouse
tube closureGO:006060610.021
positive regulation of i kappab kinase nf kappab signalingGO:004312330.021
cellular component assemblyGO:00226071700.021
positive regulation of immune effector processGO:000269930.021
transportGO:00068102200.021
cellular ketone metabolic processGO:0042180110.021
regulation of metabolic processGO:00192223590.021
Human Zebrafish Mouse
cellular component movementGO:00069283350.021
negative regulation of protein phosphorylationGO:000193340.021
lymphocyte proliferationGO:004665110.021
regulation of cell communicationGO:00106462320.021
regulation of metal ion transportGO:001095940.021
nucleobase containing compound biosynthetic processGO:00346542050.021
Human Zebrafish Mouse
cellular amino acid metabolic processGO:000652070.021
establishment of localizationGO:00512342440.021
regulation of cytokine productionGO:000181730.021
Mouse
cellular carbohydrate metabolic processGO:004426240.021
liver developmentGO:0001889960.021
regulation of stem cell proliferationGO:007209120.021
leukocyte proliferationGO:007066110.021
organic cyclic compound biosynthetic processGO:19013622230.020
Human Zebrafish Mouse
female gonad developmentGO:000858540.020
negative regulation of intracellular protein transportGO:009031730.020
regulation of synapse organizationGO:005080730.020
response to stressGO:00069502630.020
Zebrafish Mouse
determination of left right symmetryGO:00073681790.020
single organism transportGO:00447652060.020
regulation of peptidyl tyrosine phosphorylationGO:005073010.020
cell matrix adhesionGO:000716040.020
locomotionGO:00400113130.020
negative regulation of biological processGO:00485193040.020
Human Mouse
negative regulation of protein import into nucleusGO:004230820.020
digestive system developmentGO:00551232890.020
neuron developmentGO:00486662620.020
positive regulation of cell activationGO:005086710.020
positive regulation of secretionGO:005104710.020
lateral inhibitionGO:004633110.020
regulation of protein catabolic processGO:004217610.019
immune system processGO:00023762410.019
Zebrafish Mouse
regulation of autophagyGO:001050630.019
regulation of nucleoside metabolic processGO:000911820.019
regulation of biosynthetic processGO:00098892500.019
Human Zebrafish Mouse
regulation of signalingGO:00230512350.019
regulation of cell substrate adhesionGO:001081010.019
head developmentGO:00603223030.019
gene expressionGO:00104672520.019
Human Zebrafish Mouse
production of molecular mediator of immune responseGO:000244020.019
response to carbohydrateGO:000974330.019
positive regulation of cellular amino acid metabolic processGO:004576400.019
blood vessel morphogenesisGO:00485142160.018
ubiquitin dependent protein catabolic processGO:000651130.018
regulation of nucleobase containing compound metabolic processGO:00192192500.018
Human Zebrafish Mouse
protein acylationGO:004354330.018
internal peptidyl lysine acetylationGO:001839320.018
regulation of rna biosynthetic processGO:20011412130.018
Human Zebrafish Mouse
protein polyubiquitinationGO:000020940.018
protein acetylationGO:000647320.018
cell morphogenesis involved in differentiationGO:00009041950.018
lipid storageGO:001991510.018
recombinational repairGO:000072510.018
exocytosisGO:000688710.018
regulation of bindingGO:005109830.018
positive regulation of cellular amine metabolic processGO:003324000.018
cellular protein catabolic processGO:004425740.018
peptidyl lysine acetylationGO:001839420.018
immune system developmentGO:00025201910.017
macromolecule modificationGO:00434121110.017
regulation of sequestering of calcium ionGO:005128240.017
negative regulation of cellular catabolic processGO:003133030.017
protein metabolic processGO:00195381830.017
Human Mouse
peptidyl serine modificationGO:001820920.017
negative regulation of catabolic processGO:000989530.017
response to hexoseGO:000974630.017
regulation of cellular ketone metabolic processGO:001056570.017
regulation of gene expressionGO:00104682650.017
Human Zebrafish Mouse
cell morphogenesis involved in neuron differentiationGO:00486671630.017
protein secretionGO:000930610.017
embryonic organ morphogenesisGO:00485622740.017
cilium assemblyGO:0042384580.017
peptidyl serine phosphorylationGO:001810510.017
eye developmentGO:00016542770.017
membrane lipid biosynthetic processGO:004646720.017
nucleoside monophosphate catabolic processGO:000912540.017
digestive tract developmentGO:00485652650.017
hematopoietic or lymphoid organ developmentGO:00485341910.017
regulation of cellular biosynthetic processGO:00313262450.017
Human Zebrafish Mouse
embryonic organ developmentGO:00485683810.017
negative regulation of cellular processGO:00485232830.017
gastrulationGO:00073692080.017
positive regulation of cytoskeleton organizationGO:005149530.017
wnt signaling pathwayGO:0016055800.017
positive regulation of protein complex assemblyGO:003133420.017
transcription from rna polymerase ii promoterGO:0006366800.016
response to corticosteroidGO:003196010.016
locomotor rhythmGO:004547530.016
cellular protein metabolic processGO:00442671290.016
brain developmentGO:00074202930.016
cell migrationGO:00164772370.016
transcription dna templatedGO:00063511810.016
Human Zebrafish Mouse
nucleic acid transportGO:005065720.016
purine nucleoside monophosphate catabolic processGO:000912840.016
regulation of anatomical structure morphogenesisGO:00226031300.016
cellular macromolecule biosynthetic processGO:00346452240.016
Human Zebrafish Mouse
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.016
cell motilityGO:00488702440.016
positive regulation of cellular processGO:00485222010.016
Zebrafish
negative regulation of ras protein signal transductionGO:004658010.016
regulation of protein ubiquitinationGO:003139630.016
cytoskeleton dependent cytokinesisGO:006164030.016
proteolysis involved in cellular protein catabolic processGO:005160330.016
localization of cellGO:00516742440.016
positive regulation of biological processGO:00485182530.016
Zebrafish Mouse
axon developmentGO:00615641660.016
cilium morphogenesisGO:0060271850.016
hepaticobiliary system developmentGO:0061008980.016
regulation of multicellular organismal developmentGO:20000262230.016
development of primary female sexual characteristicsGO:004654540.016
signal transduction in absence of ligandGO:003803410.016
nucleic acid templated transcriptionGO:00976591810.015
Human Zebrafish Mouse
neuroblast proliferationGO:000740520.015
dorsal ventral pattern formationGO:00099531250.015
peptide transportGO:001583310.015
symbiosis encompassing mutualism through parasitismGO:004440340.015
anterior posterior pattern specificationGO:00099521520.015
cell cycle g1 s phase transitionGO:004484310.015
organelle assemblyGO:00709251100.015
epithelial tube morphogenesisGO:00605621480.015
regulation of synapse assemblyGO:005196330.015
organelle fusionGO:004828430.015
protein heterooligomerizationGO:005129110.015
regulation of signal transductionGO:00099662250.015
purine ribonucleoside monophosphate catabolic processGO:000916940.015
regulation of meiotic cell cycleGO:005144510.015
negative regulation of secretionGO:005104820.015
microtubule organizing center organizationGO:003102310.015
cellular component disassemblyGO:002241110.015
small molecule catabolic processGO:004428230.015
response to organic substanceGO:00100331530.015
Human Mouse
regulation of gtp catabolic processGO:003312420.015
carbohydrate homeostasisGO:003350010.015
regulation of macromolecule metabolic processGO:00602553170.015
Human Zebrafish Mouse
growthGO:00400071740.015
regulation of calcium ion transportGO:005192420.015
regulation of extrinsic apoptotic signaling pathwayGO:200123630.015
positive regulation of cytosolic calcium ion concentrationGO:000720440.015
actin polymerization or depolymerizationGO:000815420.015
single fertilizationGO:000733830.015
gland developmentGO:00487321430.015
ameboidal type cell migrationGO:00016671430.015
regulation of reproductive processGO:200024140.015
protein localization to plasma membraneGO:007265910.015
cellular response to chemical stimulusGO:00708871570.015
Human Mouse
mitotic dna integrity checkpointGO:004477440.014
determination of heart left right asymmetryGO:00613711170.014
positive regulation of nucleotide catabolic processGO:003081310.014
hormone secretionGO:004687920.014
sensory organ morphogenesisGO:00905962000.014
positive regulation of purine nucleotide catabolic processGO:003312310.014
modification dependent macromolecule catabolic processGO:004363230.014
meiotic cell cycle processGO:190304630.014
phosphorus metabolic processGO:00067931090.014
angiogenesisGO:00015251580.014
sequestering of metal ionGO:005123830.014
regulation of nucleotide catabolic processGO:003081120.014
golgi vesicle transportGO:004819330.014
protein modification processGO:00362111000.014
convergent extensionGO:00600261180.014
developmental growthGO:00485891660.014
chordate embryonic developmentGO:00430092710.014
negative regulation of small gtpase mediated signal transductionGO:005105810.014
negative regulation of response to stimulusGO:00485851040.014
alternative mrna splicing via spliceosomeGO:000038010.014
double strand break repair via homologous recombinationGO:000072410.014
establishment of protein localization to plasma membraneGO:009000210.014
proteasomal protein catabolic processGO:001049820.014
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.014
synaptic growth at neuromuscular junctionGO:005112420.014
osteoclast differentiationGO:003031610.014
centrosome organizationGO:005129710.014
regulation of dna replicationGO:000627530.014
double strand break repairGO:000630230.014
negative regulation of dna metabolic processGO:005105340.014
regulation of purine nucleotide catabolic processGO:003312120.014
regulation of macromolecule biosynthetic processGO:00105562250.014
Human Zebrafish Mouse
membrane fusionGO:006102520.013
renal tubule morphogenesisGO:006133310.013
response to topologically incorrect proteinGO:003596620.013
response to glucocorticoidGO:005138410.013
regulation of inflammatory responseGO:005072720.013
membrane invaginationGO:001032410.013
regulation of transporter activityGO:003240920.013
cilium organizationGO:0044782710.013
regulation of cell differentiationGO:00455951420.013
mitotic cytokinesisGO:000028130.013
single organism membrane fusionGO:004480120.013
regulation of localizationGO:00328791040.013
phosphatidylinositol mediated signalingGO:004801520.013
peptidyl threonine phosphorylationGO:001810710.013
positive regulation of chromatin modificationGO:190331010.013
cellular localizationGO:0051641970.013
neuron projection morphogenesisGO:00488121610.013
axonogenesisGO:00074091520.013
regulation of epithelial cell proliferationGO:005067830.013
regulation of cellular protein catabolic processGO:190336210.013
positive regulation of nucleoside metabolic processGO:004597910.013
rna localizationGO:000640340.013
organic acid catabolic processGO:001605430.013
endosomal transportGO:001619720.012
glucose homeostasisGO:004259310.012
rna biosynthetic processGO:00327741810.012
Human Zebrafish Mouse
digestive tract morphogenesisGO:00485462310.012
translational initiationGO:000641330.012
mitochondrial transportGO:000683920.012
response to vitaminGO:003327330.012
protein homooligomerizationGO:005126030.012
positive regulation of canonical wnt signaling pathwayGO:009026340.012
positive regulation of cytokine productionGO:000181920.012
negative regulation of secretion by cellGO:190353120.012
erk1 and erk2 cascadeGO:007037140.012
positive regulation of cell substrate adhesionGO:001081110.012
positive regulation of gtpase activityGO:004354710.012
phosphate containing compound metabolic processGO:00067961080.012
modification dependent protein catabolic processGO:001994130.012
negative regulation of kinase activityGO:003367340.012
camera type eye developmentGO:00430102220.012
cellular response to oxygen levelsGO:007145310.012
system processGO:00030081850.012
regulation of rho protein signal transductionGO:003502320.012
homeostatic processGO:00425921420.012
regulation of gtpase activityGO:004308720.012
intracellular signal transductionGO:0035556850.012
hemopoiesisGO:00300971830.012
regulation of protein modification by small protein conjugation or removalGO:190332030.012
mrna 3 end processingGO:003112420.012
cellular protein modification processGO:00064641000.012
regulation of cellular component organizationGO:0051128860.012
cellular response to hypoxiaGO:007145610.012
regulation of cellular macromolecule biosynthetic processGO:20001122220.012
Human Zebrafish Mouse
protein stabilizationGO:005082120.012
nephron tubule morphogenesisGO:007207810.012
negative regulation of defense responseGO:003134820.012
carbohydrate derivative metabolic processGO:1901135610.012
centrosome cycleGO:000709810.012
positive regulation of stress activated mapk cascadeGO:003287430.012
negative regulation of nitrogen compound metabolic processGO:0051172590.012
response to transition metal nanoparticleGO:1990267280.012
negative regulation of protein kinase activityGO:000646940.012
response to unfolded proteinGO:000698620.012
rna 3 end processingGO:003112320.012
adherens junction organizationGO:003433240.012
negative regulation of sequestering of calcium ionGO:005128340.012
regulation of mrna splicing via spliceosomeGO:004802430.012
response to external stimulusGO:00096052640.011
interspecies interaction between organismsGO:004441940.011
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.011
lipid homeostasisGO:005508830.011
positive regulation of dna metabolic processGO:005105410.011
tissue remodelingGO:004877140.011
response to uvGO:000941130.011
regulation of alternative mrna splicing via spliceosomeGO:000038110.011
negative regulation of autophagyGO:001050710.011
b cell mediated immunityGO:001972430.011
response to abiotic stimulusGO:00096281220.011
carboxylic acid catabolic processGO:004639530.011
synaptic vesicle localizationGO:009747910.011
deathGO:00162651210.011
protein complex localizationGO:003150310.011
meiotic nuclear divisionGO:000712640.011
macromolecular complex disassemblyGO:003298410.011
immunoglobulin mediated immune responseGO:001606430.011
ion transportGO:00068111140.011
embryo development ending in birth or egg hatchingGO:00097922710.011
protein complex disassemblyGO:004324110.011
response to woundingGO:00096111160.011
macromolecular complex subunit organizationGO:0043933740.011
regulation of nucleic acid templated transcriptionGO:19035062130.011
Human Zebrafish Mouse
embryonic skeletal joint developmentGO:007249830.011
lipid oxidationGO:003444010.011
regulation of neurotransmitter transportGO:005158810.011
negative regulation of signalingGO:0023057960.011
canonical wnt signaling pathwayGO:0060070480.011
phagocytosis engulfmentGO:000691110.011
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.011
regulation of carbohydrate metabolic processGO:000610940.011
periodic partitioningGO:000736510.011
viral processGO:001603210.011
regulation of microtubule cytoskeleton organizationGO:007050730.011
epiboly involved in gastrulation with mouth forming secondGO:0055113350.011
regulation of wnt signaling pathwayGO:0030111530.011
regulation of protein bindingGO:004339330.011
compound eye developmentGO:004874920.011
toll like receptor signaling pathwayGO:000222440.011
Mouse
regulation of cell developmentGO:00602841000.011
regulation of organelle assemblyGO:190211540.011
antimicrobial humoral responseGO:001973020.011
negative regulation of nuclear divisionGO:005178430.010
g1 s transition of mitotic cell cycleGO:000008210.010
regulation of cellular carbohydrate metabolic processGO:001067540.010
embryonic skeletal system developmentGO:0048706970.010
alcohol biosynthetic processGO:004616520.010
post embryonic organ developmentGO:004856940.010
negative regulation of cell communicationGO:0010648960.010
rna transportGO:005065820.010
chemosensory behaviorGO:000763510.010
regulation of synaptic growth at neuromuscular junctionGO:000858210.010
positive regulation of lymphocyte mediated immunityGO:000270810.010
negative regulation of mrna metabolic processGO:190331230.010
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.010
ear developmentGO:00435831270.010
cell substrate junction assemblyGO:000704420.010
positive regulation of notch signaling pathwayGO:004574730.010
positive regulation of erk1 and erk2 cascadeGO:007037420.010
positive regulation of gtp catabolic processGO:003312610.010
neurotransmitter transportGO:000683620.010
cellular response to xenobiotic stimulusGO:0071466350.010
single organism biosynthetic processGO:0044711710.010
positive regulation of jnk cascadeGO:004633030.010
cell migration involved in gastrulationGO:0042074790.010
negative regulation of signal transductionGO:0009968940.010
regulation of biomineral tissue developmentGO:007016720.010
regulation of erk1 and erk2 cascadeGO:007037240.010
dna templated transcription elongationGO:000635430.010
cytosolic calcium ion transportGO:006040130.010
small gtpase mediated signal transductionGO:000726480.010
regulation of transmembrane transporter activityGO:002289820.010
fertilizationGO:000956630.010
wound healingGO:0042060900.010
regulation of ion transmembrane transporter activityGO:003241220.010

traf3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.047
musculoskeletal system diseaseDOID:1700.022
muscular diseaseDOID:008000000.018
organ system cancerDOID:005068600.017
disease of cellular proliferationDOID:1456600.017
cancerDOID:16200.017
nervous system diseaseDOID:86300.016
cardiovascular system diseaseDOID:128700.016
disease of metabolismDOID:001466700.013