Danio rerio

41 known processes

psen2

presenilin 2

(Aliases: zf-PS2,pre2)

psen2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuron differentiationGO:00301823530.169
Fly
signal transductionGO:00071654550.163
regulation of primary metabolic processGO:00800903110.148
Mouse
response to external stimulusGO:00096052640.116
Worm
organic substance biosynthetic processGO:19015762890.113
Mouse
cellular protein catabolic processGO:004425740.108
Mouse
cellular component morphogenesisGO:00329893360.089
Fly
blood vessel developmentGO:00015682460.085
gene expressionGO:00104672520.084
Human Mouse
larval developmentGO:000216420.081
stem cell proliferationGO:007208940.079
cell projection organizationGO:00300302840.076
Fly
nitrogen compound metabolic processGO:00068073190.076
Zebrafish Mouse
response to chemicalGO:00422213200.075
Worm
regulation of cellular metabolic processGO:00313233200.074
Mouse
organelle fusionGO:004828430.069
cell projection morphogenesisGO:00488582440.068
Fly
generation of neuronsGO:00486993850.067
Fly
cell morphogenesisGO:00009022890.067
Fly
vasculature developmentGO:00019442780.065
Zebrafish
cellular protein metabolic processGO:00442671290.064
Mouse Fly
cognitionGO:005089010.063
Mouse
positive regulation of cellular processGO:00485222010.062
Mouse Worm
gtp metabolic processGO:004603940.062
cellular macromolecule metabolic processGO:00442603910.062
Mouse Fly
lipid storageGO:001991510.061
organic cyclic compound metabolic processGO:19013603010.059
Mouse
regulation of cell shapeGO:000836010.059
chordate embryonic developmentGO:00430092710.059
Mouse
blood vessel morphogenesisGO:00485142160.059
regulation of signal transductionGO:00099662250.058
Mouse Worm Fly
developmental growthGO:00485891660.057
single organism membrane fusionGO:004480120.056
positive regulation of cell cycleGO:004578730.056
agingGO:000756820.056
morphogenesis of an epitheliumGO:00020093330.055
protein metabolic processGO:00195381830.055
Human Zebrafish Mouse Fly
guanosine containing compound catabolic processGO:190106920.054
cell morphogenesis involved in differentiationGO:00009041950.054
amine metabolic processGO:000930820.053
regulation of synaptic plasticityGO:004816710.053
Mouse
establishment of localizationGO:00512342440.052
Mouse Fly
ubiquitin dependent protein catabolic processGO:000651130.052
Mouse
rna biosynthetic processGO:00327741810.052
Mouse
nucleobase containing compound metabolic processGO:00061392740.050
Mouse
regulation of signalingGO:00230512350.049
Mouse Worm Fly
multicellular organism growthGO:003526440.048
negative regulation of biological processGO:00485193040.048
Mouse
gtp catabolic processGO:000618420.047
guanosine containing compound metabolic processGO:190106840.047
positive regulation of transportGO:005105020.047
tube morphogenesisGO:00352393490.046
mitochondrion organizationGO:000700540.046
brain developmentGO:00074202930.046
regulation of macromolecule metabolic processGO:00602553170.046
Mouse
membrane fusionGO:006102520.046
synaptic growth at neuromuscular junctionGO:005112420.046
maintenance of locationGO:005123540.046
cellular macromolecule biosynthetic processGO:00346452240.045
Mouse
regulation of metal ion transportGO:001095940.044
regulation of biological qualityGO:00650082630.044
Mouse
cytokinesisGO:000091030.044
regulation of multicellular organism growthGO:004001440.043
regulation of metabolic processGO:00192223590.043
Human Mouse
regulation of establishment of protein localizationGO:007020140.043
positive regulation of cellular catabolic processGO:003133130.042
Mouse
positive regulation of catabolic processGO:000989640.041
Mouse
neuron projection developmentGO:00311751800.040
Fly
axon developmentGO:00615641660.040
regulation of cellular amine metabolic processGO:003323800.039
sensory organ developmentGO:00074233930.039
cellular amino acid metabolic processGO:000652070.039
neuron developmentGO:00486662620.039
Fly
regulation of synaptic growth at neuromuscular junctionGO:000858210.038
autophagyGO:000691440.038
single organism transportGO:00447652060.038
Mouse Fly
regulation of macromolecule biosynthetic processGO:00105562250.038
Mouse
intracellular signal transductionGO:0035556850.038
single organism localizationGO:19025782250.038
Mouse Fly
positive regulation of biological processGO:00485182530.037
Human Mouse Worm
cellular aromatic compound metabolic processGO:00067252950.037
Mouse
protein localization to plasma membraneGO:007265910.037
modification dependent protein catabolic processGO:001994130.037
Mouse
digestive tract morphogenesisGO:00485462310.037
response to abiotic stimulusGO:00096281220.037
Worm
regulation of synapse organizationGO:005080730.036
central nervous system developmentGO:00074173870.036
deathGO:00162651210.036
Mouse
growthGO:00400071740.035
regulation of protein transportGO:005122330.035
cellular biosynthetic processGO:00442492860.035
Mouse
organonitrogen compound metabolic processGO:1901564740.034
Zebrafish Mouse
regulation of synapse assemblyGO:005196330.034
regulation of nucleoside metabolic processGO:000911820.034
cellular amine metabolic processGO:004410620.033
apoptotic processGO:00069151160.033
Mouse
carbohydrate derivative metabolic processGO:1901135610.032
immune system developmentGO:00025201910.031
Mouse
regulation of biosynthetic processGO:00098892500.031
Mouse
cellular component movementGO:00069283350.031
protein secretionGO:000930610.031
heterocycle metabolic processGO:00464832900.031
Mouse
single organism metabolic processGO:00447102170.031
meiotic nuclear divisionGO:000712640.030
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.030
Mouse
angiogenesisGO:00015251580.030
negative regulation of protein kinase activityGO:000646940.030
Mouse
positive regulation of cellular component biogenesisGO:004408930.029
modification dependent macromolecule catabolic processGO:004363230.029
Mouse
organelle organizationGO:00069962270.029
Fly
phagocytosisGO:000690930.029
small molecule metabolic processGO:0044281770.029
muscle structure developmentGO:00610611960.028
cellular response to chemical stimulusGO:00708871570.028
Worm
oxoacid metabolic processGO:0043436310.028
regulation of programmed cell deathGO:00430671010.028
Mouse
positive regulation of cellular metabolic processGO:0031325940.028
Mouse
digestive tract developmentGO:00485652650.028
biosynthetic processGO:00090582940.028
Mouse
positive regulation of cellular amino acid metabolic processGO:004576400.028
cell part morphogenesisGO:00329902460.028
Fly
cellular response to extracellular stimulusGO:003166820.028
regulation of transcription dna templatedGO:00063552130.028
Mouse
regulation of protein complex assemblyGO:004325430.028
Mouse
macromolecule modificationGO:00434121110.027
Mouse
organic acid metabolic processGO:0006082310.027
nucleic acid templated transcriptionGO:00976591810.027
Mouse
cellular nitrogen compound metabolic processGO:00346412900.027
Zebrafish Mouse
cellular nitrogen compound biosynthetic processGO:00442712180.027
Mouse
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.027
Mouse
response to unfolded proteinGO:000698620.027
digestive system developmentGO:00551232890.027
regulation of cellular ketone metabolic processGO:001056570.027
cell migrationGO:00164772370.027
carboxylic acid metabolic processGO:0019752220.026
nucleocytoplasmic transportGO:000691340.026
regulation of cytokine productionGO:000181730.026
cellular ketone metabolic processGO:0042180110.026
cellular component biogenesisGO:00440851780.026
Mouse
regulation of cell deathGO:00109411030.026
Mouse
rna localizationGO:000640340.026
meiotic cell cycle processGO:190304630.025
regulation of purine nucleotide catabolic processGO:003312120.025
negative regulation of kinase activityGO:003367340.025
Mouse
somite developmentGO:0061053960.025
neuroblast proliferationGO:000740520.025
peptidyl serine modificationGO:001820920.025
cytoskeleton dependent cytokinesisGO:006164030.024
regulation of nucleotide catabolic processGO:003081120.024
regulation of stem cell proliferationGO:007209120.024
regulation of bindingGO:005109830.024
Mouse
peptidyl serine phosphorylationGO:001810510.023
aromatic compound biosynthetic processGO:00194382170.023
Mouse
regulation of intracellular protein transportGO:003315730.023
response to stressGO:00069502630.023
response to drugGO:004249330.023
macromolecule biosynthetic processGO:00090592270.023
Mouse
regulation of cellular macromolecule biosynthetic processGO:20001122220.023
Mouse
negative regulation of protein phosphorylationGO:000193340.023
Mouse
cell morphogenesis involved in neuron differentiationGO:00486671630.023
positive regulation of secretion by cellGO:190353210.023
nucleic acid metabolic processGO:00903042440.022
Mouse
neurotransmitter secretionGO:000726920.022
cellular response to organic substanceGO:00713101050.022
Worm
positive regulation of nucleoside metabolic processGO:004597910.022
regulation of cellular amino acid metabolic processGO:000652100.022
nuclear transportGO:005116940.022
muscle cell developmentGO:00550011150.022
response to organic substanceGO:00100331530.022
Worm
camera type eye developmentGO:00430102220.022
embryonic limb morphogenesisGO:003032620.022
Mouse
regulation of developmental processGO:00507932470.022
sensory perception of painGO:001923310.022
head developmentGO:00603223030.022
establishment of protein localization to organelleGO:007259440.021
cellular response to nutrient levelsGO:003166920.021
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:004278710.021
Mouse
lateral inhibitionGO:004633110.021
Fly
extrinsic apoptotic signaling pathwayGO:009719130.021
Mouse
positive regulation of gtp catabolic processGO:003312610.021
positive regulation of macromolecule metabolic processGO:0010604930.021
Mouse
locomotionGO:00400113130.021
Mouse
nucleobase containing compound biosynthetic processGO:00346542050.021
Mouse
regulation of peptidase activityGO:0052547230.021
cellular carbohydrate metabolic processGO:004426240.020
positive regulation of nucleotide catabolic processGO:003081310.020
establishment of protein localization to plasma membraneGO:009000210.020
cell motilityGO:00488702440.020
negative regulation of cellular processGO:00485232830.020
Mouse
purine nucleoside monophosphate catabolic processGO:000912840.020
neurotransmitter transportGO:000683620.020
determination of left right symmetryGO:00073681790.020
regulation of cell communicationGO:00106462320.020
Mouse Worm Fly
cellular protein modification processGO:00064641000.020
Mouse
erk1 and erk2 cascadeGO:007037140.020
positive regulation of gtpase activityGO:004354710.020
single organism organelle organizationGO:19025891990.020
regulation of nitrogen compound metabolic processGO:00511712510.019
Mouse
membrane invaginationGO:001032410.019
taxisGO:00423301090.019
programmed cell deathGO:00125011190.019
Mouse
glucose homeostasisGO:004259310.019
regulation of meiotic cell cycleGO:005144510.019
rna metabolic processGO:00160702190.019
Mouse
regulation of protein catabolic processGO:004217610.019
Mouse
regulation of organ growthGO:004662030.019
regulation of apoptotic processGO:0042981980.019
Mouse
regulation of gtp catabolic processGO:003312420.019
stem cell divisionGO:001714510.019
cellular component maintenanceGO:004395430.019
regulation of endopeptidase activityGO:0052548230.019
cell proliferationGO:0008283800.019
small gtpase mediated signal transductionGO:000726480.019
cellular component assemblyGO:00226071700.019
Mouse
negative regulation of apoptotic processGO:0043066550.019
Mouse
hemopoiesisGO:00300971830.019
Mouse
regulation of protein ubiquitinationGO:003139630.019
Mouse
cellular component disassemblyGO:002241110.019
epithelial cell morphogenesisGO:000338220.019
positive regulation of secretionGO:005104710.019
positive regulation of protein complex assemblyGO:003133420.018
regulation of cytoplasmic transportGO:190364940.018
actomyosin structure organizationGO:0031032530.018
regionalizationGO:00030022740.018
Mouse Fly
exocytosisGO:000688710.018
regulation of circadian rhythmGO:004275240.018
heart developmentGO:00075073130.018
regulation of cellular biosynthetic processGO:00313262450.018
Mouse
phagocytosis engulfmentGO:000691110.018
somitogenesisGO:0001756870.018
Mouse
eye developmentGO:00016542770.018
positive regulation of purine nucleotide catabolic processGO:003312310.018
response to oxygen levelsGO:0070482250.018
response to alkaloidGO:004327920.018
primary neural tube formationGO:001402010.018
cell substrate adhesionGO:003158940.018
protein acylationGO:004354330.017
regulation of protein modification by small protein conjugation or removalGO:190332030.017
Mouse
system processGO:00030081850.017
Mouse
regulation of nucleobase containing compound metabolic processGO:00192192500.017
Mouse
regulation of protein metabolic processGO:0051246560.017
Mouse
golgi vesicle transportGO:004819330.017
regulation of peptidyl tyrosine phosphorylationGO:005073010.017
Mouse
regulation of anatomical structure morphogenesisGO:00226031300.017
embryonic organ developmentGO:00485683810.017
muscle cell differentiationGO:00426921390.017
cell surface receptor signaling pathwayGO:00071663250.017
cellular response to external stimulusGO:007149620.017
lipid catabolic processGO:001604240.017
transcription dna templatedGO:00063511810.017
Mouse
cilium morphogenesisGO:0060271850.017
positive regulation of cellular amine metabolic processGO:003324000.017
regulation of nucleic acid templated transcriptionGO:19035062130.016
Mouse
organelle localizationGO:0051640490.016
positive regulation of cytoskeleton organizationGO:005149530.016
response to inorganic substanceGO:0010035380.016
negative regulation of cytokine productionGO:000181810.016
regulation of reproductive processGO:200024140.016
cellular response to starvationGO:000926710.016
proteolysis involved in cellular protein catabolic processGO:005160330.016
Mouse
regulation of dendrite developmentGO:005077330.016
cell deathGO:00082191210.016
Mouse
ameboidal type cell migrationGO:00016671430.016
carbohydrate homeostasisGO:003350010.016
protein complex disassemblyGO:004324110.016
neuron projection morphogenesisGO:00488121610.016
Fly
localization of cellGO:00516742440.016
macromolecule localizationGO:0033036540.016
Mouse Worm
actin filament based processGO:0030029640.016
negative regulation of synapse assemblyGO:005196420.016
protein polymerizationGO:005125840.016
positive regulation of metabolic processGO:00098931080.016
Human Mouse
retina development in camera type eyeGO:00600411460.016
chemotaxisGO:00069351040.015
regulation of proteolysisGO:0030162240.015
Mouse
gastrulationGO:00073692080.015
immune system processGO:00023762410.015
Mouse
regulation of epithelial cell proliferationGO:005067830.015
organic substance transportGO:0071702580.015
Mouse
positive regulation of signalingGO:0023056560.015
Mouse Worm
axonogenesisGO:00074091520.015
compound eye developmentGO:004874920.015
regulation of gtpase activityGO:004308720.015
positive regulation of cytokine productionGO:000181920.015
regulation of cellular component organizationGO:0051128860.015
Mouse
renal system developmentGO:0072001940.015
regulation of cellular protein catabolic processGO:190336210.015
Mouse
regulation of cell developmentGO:00602841000.015
sensory perception of chemical stimulusGO:000760630.015
regulation of molecular functionGO:0065009700.015
Human Mouse
mesenchyme developmentGO:00604851270.015
regulation of wound healingGO:006104120.014
positive regulation of erk1 and erk2 cascadeGO:007037420.014
phosphorus metabolic processGO:00067931090.014
Mouse
cellular amide metabolic processGO:004360340.014
Zebrafish Mouse
stem cell maintenanceGO:001982740.014
striated muscle cell differentiationGO:00511461290.014
adult behaviorGO:003053420.014
developmental programmed cell deathGO:001062340.014
regulation of erk1 and erk2 cascadeGO:007037240.014
signal transduction in absence of ligandGO:003803410.014
embryo development ending in birth or egg hatchingGO:00097922710.014
Mouse
actin filament based movementGO:003004810.014
cellular respirationGO:004533330.014
carboxylic acid catabolic processGO:004639530.014
macromolecular complex assemblyGO:0065003350.014
Mouse
neurological system processGO:0050877620.014
Mouse
hematopoietic or lymphoid organ developmentGO:00485341910.014
Mouse
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.014
cortical actin cytoskeleton organizationGO:003086610.014
post embryonic organ developmentGO:004856940.014
Worm
cellular response to endogenous stimulusGO:0071495680.014
Worm
interspecies interaction between organismsGO:004441940.014
regulation of multicellular organismal developmentGO:20000262230.014
positive regulation of stem cell proliferationGO:200064810.014
striated muscle cell developmentGO:00550021080.014
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.014
Mouse
cilium organizationGO:0044782710.014
regulation of response to oxidative stressGO:190288220.014
gland developmentGO:00487321430.014
Mouse
positive regulation of apoptotic processGO:0043065290.013
Mouse
positive regulation of i kappab kinase nf kappab signalingGO:004312330.013
cellular component assembly involved in morphogenesisGO:00109271070.013
developmental growth involved in morphogenesisGO:0060560860.013
negative regulation of secretionGO:005104820.013
regulation of reactive oxygen species metabolic processGO:200037720.013
ras protein signal transductionGO:000726570.013
regulation of protein targetingGO:190353320.013
actin polymerization or depolymerizationGO:000815420.013
positive regulation of wound healingGO:009030310.013
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.013
regulation of i kappab kinase nf kappab signalingGO:004312240.013
negative regulation of catabolic processGO:000989530.013
Mouse
regulation of microtubule cytoskeleton organizationGO:007050730.013
positive regulation of map kinase activityGO:004340630.013
ribonucleoside monophosphate catabolic processGO:000915840.013
establishment of organelle localizationGO:0051656450.013
regulation of autophagyGO:001050630.013
positive regulation of response to stimulusGO:0048584800.013
Mouse Worm
cell cycle arrestGO:000705010.013
positive regulation of gene expressionGO:0010628710.013
adherens junction organizationGO:003433240.012
transportGO:00068102200.012
Mouse Fly
response to monosaccharideGO:003428430.012
regulation of neurotransmitter secretionGO:004692810.012
negative regulation of rna splicingGO:003311910.012
regulation of extrinsic apoptotic signaling pathwayGO:200123630.012
Mouse
organophosphate metabolic processGO:0019637370.012
epithelial tube morphogenesisGO:00605621480.012
cellular response to stressGO:0033554620.012
protein importGO:001703830.012
homeostatic processGO:00425921420.012
Mouse
positive regulation of nitrogen compound metabolic processGO:0051173690.012
hindbrain developmentGO:0030902910.012
cell growthGO:0016049570.012
negative regulation of macromolecule metabolic processGO:0010605760.012
Mouse
eye morphogenesisGO:00485921440.012
protein acetylationGO:000647320.012
positive regulation of signal transductionGO:0009967560.012
Mouse Worm
positive regulation of cell divisionGO:005178120.012
atp catabolic processGO:000620040.012
regulation of dna replicationGO:000627530.012
regulation of translational initiationGO:000644610.012
protein localization to nucleusGO:003450430.012
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.012
Mouse
alpha amino acid metabolic processGO:190160530.012
regulation of locomotionGO:0040012550.012
chemosensory behaviorGO:000763510.011
hepaticobiliary system developmentGO:0061008980.011
fatty acid beta oxidationGO:000663510.011
regulation of protein import into nucleusGO:004230620.011
neuron apoptotic processGO:0051402200.011
regulation of rna metabolic processGO:00512522240.011
Mouse
symbiosis encompassing mutualism through parasitismGO:004440340.011
phosphate containing compound metabolic processGO:00067961080.011
Mouse
regulation of response to stimulusGO:00485832690.011
Mouse Worm Fly
regulation of cell projection organizationGO:0031344440.011
cellular response to organic cyclic compoundGO:0071407380.011
liver developmentGO:0001889960.011
hormone secretionGO:004687920.011
cellular localizationGO:0051641970.011
cell matrix adhesionGO:000716040.011
establishment of rna localizationGO:005123630.011
embryonic organ morphogenesisGO:00485622740.011
regulation of receptor mediated endocytosisGO:004825940.011
cortical cytoskeleton organizationGO:003086510.011
cytokinetic processGO:003250620.011
regulation of inflammatory responseGO:005072720.011
macromolecular complex disassemblyGO:003298410.011
tissue remodelingGO:004877140.011
anterior posterior pattern specificationGO:00099521520.011
Mouse
tube closureGO:006060610.011
cilium assemblyGO:0042384580.011
purine ribonucleoside monophosphate catabolic processGO:000916940.011
regulation of embryonic developmentGO:0045995470.011
positive regulation of stress activated mapk cascadeGO:003287430.011
embryonic heart tube developmentGO:00350501330.011
cell projection assemblyGO:0030031640.011
regulation of hydrolase activityGO:0051336280.011
glucose importGO:004632320.011
regulation of membrane potentialGO:0042391230.011
regulation of filopodium assemblyGO:005148920.011
morphogenesis of embryonic epitheliumGO:0016331300.011
negative regulation of epithelial cell proliferationGO:005068010.011
convergent extensionGO:00600261180.011
protein homooligomerizationGO:005126030.011
cellular biogenic amine metabolic processGO:000657620.011
regulation of intracellular signal transductionGO:1902531570.011
protein modification processGO:00362111000.011
Mouse
cellular catabolic processGO:0044248270.011
Mouse
cellular response to hormone stimulusGO:0032870390.011
anatomical structure homeostasisGO:0060249360.011
regulation of neural precursor cell proliferationGO:200017730.011
cell cycleGO:0007049930.011
activation of mapk activityGO:000018730.011
mrna 3 end processingGO:003112420.011
secondary metabolic processGO:001974830.010
negative regulation of catalytic activityGO:0043086210.010
Mouse
cytoskeleton organizationGO:0007010960.010
Fly
negative regulation of programmed cell deathGO:0043069580.010
Mouse
rna 3 end processingGO:003112320.010
regulation of transcription from rna polymerase ii promoterGO:00063571140.010
Mouse
skeletal system developmentGO:00015011810.010
negative regulation of protein complex assemblyGO:003133310.010
Mouse
endosomal transportGO:001619720.010
negative regulation of secretion by cellGO:190353120.010
positive regulation of notch signaling pathwayGO:004574730.010
Worm
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.010
nephron morphogenesisGO:007202820.010
regulation of fatty acid metabolic processGO:001921710.010
regulation of multicellular organismal processGO:00512392770.010
Mouse
peptide metabolic processGO:000651810.010
Zebrafish Mouse
negative regulation of multi organism processGO:004390130.010
negative regulation of dna metabolic processGO:005105340.010
positive regulation of apoptotic signaling pathwayGO:200123510.010
Mouse
gastrulation with mouth forming secondGO:0001702440.010
response to glucoseGO:000974930.010
regulation of response to cytokine stimulusGO:006075930.010
regulation of rna biosynthetic processGO:20011412130.010
Mouse
regulation of gene expressionGO:00104682650.010
Mouse

psen2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.056
Human
nervous system diseaseDOID:86300.029
Human
disease of metabolismDOID:001466700.027
disease of cellular proliferationDOID:1456600.015
cancerDOID:16200.013
organ system cancerDOID:005068600.013
inherited metabolic disorderDOID:65500.012
immune system diseaseDOID:291400.011