Danio rerio

68 known processes

cx43

connexin 43

(Aliases: gja1,cx43a1,zfCx43.3)

cx43 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
system processGO:00030081850.926
Zebrafish Mouse
regulation of macromolecule metabolic processGO:00602553170.925
Mouse
sensory organ morphogenesisGO:00905962000.877
multicellular organism growthGO:003526440.855
nucleobase containing compound metabolic processGO:00061392740.845
sensory organ developmentGO:00074233930.823
Zebrafish Mouse
cellular aromatic compound metabolic processGO:00067252950.811
response to stressGO:00069502630.728
phosphate containing compound metabolic processGO:00067961080.721
organic cyclic compound metabolic processGO:19013603010.713
nitrogen compound metabolic processGO:00068073190.710
regulation of primary metabolic processGO:00800903110.699
cation transportGO:0006812810.669
macromolecular complex subunit organizationGO:0043933740.658
regulation of nitrogen compound metabolic processGO:00511712510.630
single organism localizationGO:19025782250.587
regulation of cellular metabolic processGO:00313233200.551
establishment of localizationGO:00512342440.549
regulation of catalytic activityGO:0050790550.548
positive regulation of biological processGO:00485182530.504
Human Mouse
gene expressionGO:00104672520.484
Mouse
nuclear divisionGO:0000280230.481
nucleic acid metabolic processGO:00903042440.468
tube morphogenesisGO:00352393490.461
Mouse
heterocycle biosynthetic processGO:00181302150.445
negative regulation of cellular processGO:00485232830.423
negative regulation of biological processGO:00485193040.417
Mouse
cellular nitrogen compound metabolic processGO:00346412900.409
cell surface receptor signaling pathwayGO:00071663250.407
positive regulation of macromolecule metabolic processGO:0010604930.404
Mouse
heterocycle metabolic processGO:00464832900.384
eye morphogenesisGO:00485921440.378
heart developmentGO:00075073130.375
blood vessel developmentGO:00015682460.372
Mouse
regulation of signalingGO:00230512350.365
Human
aromatic compound biosynthetic processGO:00194382170.353
organelle fissionGO:0048285230.346
organonitrogen compound metabolic processGO:1901564740.345
small molecule metabolic processGO:0044281770.339
regulation of macromolecule biosynthetic processGO:00105562250.338
negative regulation of signal transductionGO:0009968940.320
specification of symmetryGO:00097992040.317
Mouse
positive regulation of biosynthetic processGO:0009891680.317
ion transportGO:00068111140.310
Zebrafish Mouse
eye developmentGO:00016542770.303
Mouse
signal transductionGO:00071654550.298
Human
oxoacid metabolic processGO:0043436310.293
single organism biosynthetic processGO:0044711710.280
cellular component morphogenesisGO:00329893360.243
Zebrafish
cell cycle g1 s phase transitionGO:004484310.243
positive regulation of cellular metabolic processGO:0031325940.240
response to decreased oxygen levelsGO:0036293250.239
defense responseGO:0006952470.236
regulation of nucleobase containing compound metabolic processGO:00192192500.235
cellular biosynthetic processGO:00442492860.235
positive regulation of cellular processGO:00485222010.229
Human Mouse
response to hypoxiaGO:0001666250.221
purine containing compound metabolic processGO:0072521290.216
head developmentGO:00603223030.201
regulation of dna metabolic processGO:0051052110.198
regulation of erk1 and erk2 cascadeGO:007037240.197
regulation of cellular biosynthetic processGO:00313262450.196
regulation of metabolic processGO:00192223590.194
Mouse
regulation of cell communicationGO:00106462320.191
Human
response to organic cyclic compoundGO:0014070510.186
nucleotide metabolic processGO:0009117280.186
regulation of hydrolase activityGO:0051336280.177
cell part morphogenesisGO:00329902460.175
larval developmentGO:000216420.174
regulation of signal transductionGO:00099662250.168
Human
cell morphogenesis involved in differentiationGO:00009041950.166
cardiac cell developmentGO:0055006210.164
Zebrafish
mitotic cell cycle processGO:1903047480.162
meiotic nuclear divisionGO:000712640.160
positive regulation of apoptotic processGO:0043065290.157
neuromast depositionGO:004888590.156
regulation of gene expressionGO:00104682650.156
Mouse
carboxylic acid metabolic processGO:0019752220.154
carbohydrate derivative metabolic processGO:1901135610.151
amine metabolic processGO:000930820.151
digestive system developmentGO:00551232890.149
positive regulation of nitrogen compound metabolic processGO:0051173690.145
brain developmentGO:00074202930.133
regulation of bindingGO:005109830.131
rna metabolic processGO:00160702190.129
regulation of molecular functionGO:0065009700.129
heart processGO:0003015710.126
Mouse
gtp catabolic processGO:000618420.125
response to estrogenGO:0043627270.125
nucleobase containing compound biosynthetic processGO:00346542050.124
regulation of biological qualityGO:00650082630.123
Mouse
regulation of response to stimulusGO:00485832690.122
Human
regulation of programmed cell deathGO:00430671010.121
positive regulation of catalytic activityGO:0043085250.120
cranial suture morphogenesisGO:006036310.119
organic cyclic compound biosynthetic processGO:19013622230.118
regulation of multicellular organismal developmentGO:20000262230.117
Mouse
cell migrationGO:00164772370.117
Mouse
positive regulation of programmed cell deathGO:0043068290.114
transportGO:00068102200.113
macromolecular complex assemblyGO:0065003350.112
negative regulation of cellular metabolic processGO:0031324770.109
positive regulation of molecular functionGO:0044093330.106
regulation of multicellular organism growthGO:004001440.105
cellular nitrogen compound biosynthetic processGO:00442712180.105
cellular amine metabolic processGO:004410620.104
negative regulation of cell communicationGO:0010648960.102
agingGO:000756820.100
dicarboxylic acid metabolic processGO:004364810.098
organophosphate metabolic processGO:0019637370.097
ribonucleotide metabolic processGO:0009259270.097
regulation of biosynthetic processGO:00098892500.095
proteolysis involved in cellular protein catabolic processGO:005160330.094
protein metabolic processGO:00195381830.094
cellular macromolecule biosynthetic processGO:00346452240.093
regulation of cell proliferationGO:0042127370.093
positive regulation of nuclease activityGO:003207510.092
regulation of cellular macromolecule biosynthetic processGO:20001122220.092
hepatocyte differentiationGO:007036510.090
actin cytoskeleton organizationGO:0030036630.090
Zebrafish
embryonic organ developmentGO:00485683810.089
camera type eye developmentGO:00430102220.089
Mouse
macromolecule biosynthetic processGO:00090592270.087
dna metabolic processGO:0006259270.087
regulation of cytokine productionGO:000181730.086
regulation of multicellular organismal processGO:00512392770.083
Mouse
germ line stem cell maintenanceGO:003071820.083
nucleic acid templated transcriptionGO:00976591810.083
mitotic cell cycleGO:0000278640.083
modification dependent macromolecule catabolic processGO:004363230.081
regulation of intracellular signal transductionGO:1902531570.081
Human
positive regulation of cell deathGO:0010942290.080
chordate embryonic developmentGO:00430092710.079
cell cycleGO:0007049930.078
response to abiotic stimulusGO:00096281220.078
sensory perceptionGO:0007600390.078
Zebrafish
neurological system processGO:0050877620.076
Zebrafish
wnt signaling pathwayGO:0016055800.074
positive regulation of erk1 and erk2 cascadeGO:007037420.074
macromolecule localizationGO:0033036540.072
morphogenesis of an epitheliumGO:00020093330.071
Mouse
regulation of cellular amine metabolic processGO:003323800.071
erk1 and erk2 cascadeGO:007037140.069
regulation of cell activationGO:005086510.069
regulation of rna biosynthetic processGO:20011412130.069
positive regulation of hydrolase activityGO:0051345130.068
regulation of oligodendrocyte differentiationGO:004871310.068
positive regulation of cell activationGO:005086710.066
cognitionGO:005089010.066
regulation of protein metabolic processGO:0051246560.066
regulation of localizationGO:00328791040.065
ras protein signal transductionGO:000726570.065
regulation of erythrocyte differentiationGO:004564620.064
heart morphogenesisGO:00030071560.064
Mouse
positive regulation of glial cell differentiationGO:004568710.064
response to endogenous stimulusGO:0009719830.062
renal absorptionGO:007029310.062
positive regulation of phosphate metabolic processGO:0045937210.062
camera type eye morphogenesisGO:00485931080.062
regulation of protein modification processGO:0031399290.061
positive regulation of nucleobase containing compound metabolic processGO:0045935690.060
biosynthetic processGO:00090582940.059
cytoskeleton organizationGO:0007010960.059
Zebrafish
positive regulation of cytokine productionGO:000181920.059
response to amino acidGO:004320020.058
regulation of transportGO:0051049450.058
single organism metabolic processGO:00447102170.058
ventricular cardiac muscle cell differentiationGO:005501260.056
cellular amino acid metabolic processGO:000652070.055
phosphorus metabolic processGO:00067931090.054
camp metabolic processGO:0046058110.052
trabecula formationGO:006034320.052
response to hormoneGO:0009725480.052
regulation of endothelial cell proliferationGO:000193610.052
positive regulation of catabolic processGO:000989640.051
oxidative demethylationGO:007098910.050
organic substance biosynthetic processGO:19015762890.049
response to oxygen levelsGO:0070482250.048
muscle cell differentiationGO:00426921390.047
Zebrafish
behaviorGO:0007610740.046
cellular protein catabolic processGO:004425740.046
taxisGO:00423301090.046
negative regulation of developmental processGO:0051093650.046
monovalent inorganic cation transportGO:0015672420.046
positive regulation of immune system processGO:0002684170.046
cell proliferationGO:0008283800.045
cellular component movementGO:00069283350.043
Mouse
cell motilityGO:00488702440.043
Mouse
modification dependent protein catabolic processGO:001994130.042
regulation of protein bindingGO:004339330.042
response to oxygen containing compoundGO:1901700550.041
single organism transportGO:00447652060.041
regulation of cellular protein metabolic processGO:0032268520.041
regulation of transcription involved in cell fate commitmentGO:006085010.040
positive regulation of transportGO:005105020.040
positive regulation of multicellular organismal processGO:0051240520.040
Mouse
cardiac conduction system developmentGO:000316110.040
dopaminergic neuron differentiationGO:0071542140.040
positive regulation of cellular biosynthetic processGO:0031328680.039
nucleobase containing small molecule metabolic processGO:0055086320.039
regulation of transcription dna templatedGO:00063552130.039
protein complex subunit organizationGO:0071822460.039
positive regulation of striated muscle cell differentiationGO:005115510.039
organic acid metabolic processGO:0006082310.039
cellular component biogenesisGO:00440851780.038
Zebrafish
proteolysisGO:0006508380.038
regulation of cell cycleGO:0051726520.038
response to external stimulusGO:00096052640.038
Mouse
negative regulation of leukocyte differentiationGO:190210610.038
proteasomal protein catabolic processGO:001049820.037
positive regulation of metabolic processGO:00098931080.037
Mouse
negative regulation of macromolecule metabolic processGO:0010605760.036
Mouse
locomotory behaviorGO:0007626340.036
oogenesisGO:0048477140.035
regulation of collagen metabolic processGO:001071220.035
cardiac muscle tissue developmentGO:0048738480.035
Zebrafish
regulation of cell migrationGO:0030334400.034
positive regulation of cellular amine metabolic processGO:003324000.034
negative regulation of intracellular signal transductionGO:1902532220.033
positive regulation of gliogenesisGO:001401520.033
response to corticosteroidGO:003196010.033
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.033
positive regulation of secretionGO:005104710.033
negative regulation of signalingGO:0023057960.033
cellular protein modification processGO:00064641000.032
endocardial cushion formationGO:000327220.032
glucocorticoid biosynthetic processGO:000670410.032
ubiquitin dependent protein catabolic processGO:000651130.032
gtp metabolic processGO:004603940.032
determination of left right symmetryGO:00073681790.031
Mouse
positive regulation of cell differentiationGO:0045597300.031
Mouse
positive regulation of developmental processGO:0051094500.031
Mouse
g1 s transition of mitotic cell cycleGO:000008210.031
heterocycle catabolic processGO:0046700150.030
response to chemicalGO:00422213200.030
ventricular cardiac muscle cell developmentGO:005501550.030
basement membrane organizationGO:007171150.030
regionalizationGO:00030022740.030
positive regulation of cell cycleGO:004578730.029
regulation of rho protein signal transductionGO:003502320.028
purine nucleotide metabolic processGO:0006163270.028
immune system developmentGO:00025201910.027
mitotic nuclear divisionGO:0007067180.027
negative regulation of metabolic processGO:0009892860.027
Mouse
specification of organ positionGO:001015930.026
endocardial cushion developmentGO:000319760.026
regulation of cellular component organizationGO:0051128860.026
negative regulation of protein serine threonine kinase activityGO:007190120.026
embryonic heart tube developmentGO:00350501330.026
cell cycle processGO:0022402530.026
regulation of cellular amino acid metabolic processGO:000652100.025
positive regulation of myeloid leukocyte differentiationGO:000276310.025
regulation of protein phosphorylationGO:0001932180.025
digestive tract morphogenesisGO:00485462310.025
negative regulation of response to stimulusGO:00485851040.025
regulation of gtp catabolic processGO:003312420.025
otic vesicle developmentGO:0071599420.024
regulation of protein ubiquitinationGO:003139630.024
ear morphogenesisGO:0042471640.024
regulation of cell cycle processGO:0010564200.024
small gtpase mediated signal transductionGO:000726480.024
heart contractionGO:0060047710.024
Mouse
cellular response to dna damage stimulusGO:0006974240.024
negative regulation of epithelial cell proliferationGO:005068010.024
single organism behaviorGO:0044708240.024
cellular response to hormone stimulusGO:0032870390.024
regulation of inflammatory responseGO:005072720.024
response to nutrientGO:000758430.023
photoreceptor cell differentiationGO:0046530550.023
muscle contractionGO:0006936180.023
immunoglobulin productionGO:000237710.023
endodermal digestive tract morphogenesisGO:006103120.022
regulation of phosphate metabolic processGO:0019220430.022
regulation of cell substrate adhesionGO:001081010.022
neuron differentiationGO:00301823530.022
response to heatGO:000940860.022
negative regulation of nitrogen compound metabolic processGO:0051172590.022
ribose phosphate metabolic processGO:0019693270.022
striated muscle tissue developmentGO:00147061100.022
Zebrafish Mouse
regulation of nucleotide catabolic processGO:003081120.022
regulation of cellular ketone metabolic processGO:001056570.021
posterior lateral line developmentGO:0048916380.021
regulation of insulin like growth factor receptor signaling pathwayGO:004356710.021
regulation of dna catabolic processGO:190362410.021
response to oxidative stressGO:0006979110.021
negative regulation of cellular catabolic processGO:003133030.021
determination of bilateral symmetryGO:00098552040.021
Mouse
insulin like growth factor receptor signaling pathwayGO:004800940.021
regulation of neural precursor cell proliferationGO:200017730.020
glucocorticoid metabolic processGO:000821120.020
defense response to fungusGO:005083220.020
regulation of wnt signaling pathwayGO:0030111530.020
ear developmentGO:00435831270.020
Zebrafish
innervationGO:006038430.020
meiotic cell cycle processGO:190304630.020
negative regulation of dna metabolic processGO:005105340.020
negative regulation of protein phosphorylationGO:000193340.020
positive regulation of apoptotic signaling pathwayGO:200123510.020
ameboidal type cell migrationGO:00016671430.019
cardiac muscle cell differentiationGO:0055007300.019
Zebrafish
cellular response to external stimulusGO:007149620.019
organic substance transportGO:0071702580.019
cell substrate adhesionGO:003158940.019
meiotic chromosome segregationGO:004513230.019
locomotionGO:00400113130.019
Mouse
embryonic heart tube morphogenesisGO:00031431080.019
Mouse
protein acylationGO:004354330.019
regulation of phosphorus metabolic processGO:0051174430.019
maintenance of locationGO:005123540.019
endocardial cushion morphogenesisGO:000320330.019
dephosphorylationGO:0016311110.018
protein phosphorylationGO:0006468470.018
lipid metabolic processGO:0006629520.018
intracellular signal transductionGO:0035556850.018
Human
cardiac chamber developmentGO:0003205190.018
negative regulation of kinase activityGO:003367340.018
peptidyl serine phosphorylationGO:001810510.018
response to lipidGO:0033993600.018
peptidyl serine modificationGO:001820920.018
regulation of cell divisionGO:0051302120.017
extracellular matrix constituent secretionGO:007027830.017
regulation of multicellular organismal metabolic processGO:004424620.017
protein complex assemblyGO:0006461300.017
actin filament based processGO:0030029640.017
Zebrafish
metal ion transportGO:0030001580.017
ovarian follicle developmentGO:000154120.017
locomotor rhythmGO:004547530.017
striated muscle cell differentiationGO:00511461290.017
Zebrafish
ossificationGO:0001503230.017
Mouse
positive regulation of myeloid cell differentiationGO:004563920.017
negative regulation of biosynthetic processGO:0009890550.017
positive regulation of phosphorus metabolic processGO:0010562210.017
response to woundingGO:00096111160.016
astrocyte differentiationGO:004870810.016
cardiac chamber morphogenesisGO:0003206120.016
muscle structure developmentGO:00610611960.016
Zebrafish Mouse
trabecula morphogenesisGO:006138320.016
purine nucleoside triphosphate metabolic processGO:000914490.016
response to organonitrogen compoundGO:0010243120.016
negative regulation of angiogenesisGO:001652570.016
positive regulation of gtpase activityGO:004354710.016
hepaticobiliary system developmentGO:0061008980.016
dna templated transcription initiationGO:000635210.016
positive regulation of gene expressionGO:0010628710.016
Mouse
guanosine containing compound metabolic processGO:190106840.016
protein stabilizationGO:005082120.016
regulation of nucleoside metabolic processGO:000911820.016
positive regulation of locomotionGO:0040017140.016
positive regulation of purine nucleotide catabolic processGO:003312310.015
cell migration involved in heart developmentGO:0060973220.015
chemotaxisGO:00069351040.015
cell cycle g2 m phase transitionGO:004483940.015
purine ribonucleotide metabolic processGO:0009150270.015
response to vitaminGO:003327330.015
embryo development ending in birth or egg hatchingGO:00097922710.015
muscle system processGO:0003012200.015
organonitrogen compound biosynthetic processGO:1901566470.015
regulation of developmental growthGO:0048638380.015
neuron projection developmentGO:00311751800.015
cellular transition metal ion homeostasisGO:004691630.015
muscle hypertrophyGO:001489620.015
urogenital system developmentGO:0001655970.014
cell migration involved in heart formationGO:0060974100.014
regulation of transcription from rna polymerase ii promoterGO:00063571140.014
protein destabilizationGO:003164810.014
female meiosis chromosome segregationGO:001632110.014
heart loopingGO:0001947940.014
Mouse
posttranscriptional regulation of gene expressionGO:0010608140.014
regulation of locomotionGO:0040012550.014
cell fate specificationGO:0001708680.014
regulation of cell motilityGO:2000145460.014
atrioventricular valve formationGO:000319030.014
erythrocyte differentiationGO:0030218540.014
regulation of nuclease activityGO:003206910.014
neuroblast fate determinationGO:000740010.014
inner ear morphogenesisGO:0042472630.013
ion transmembrane transportGO:0034220910.013
Zebrafish Mouse
kidney morphogenesisGO:0060993150.013
response to peptide hormoneGO:004343460.013
liver developmentGO:0001889960.013
positive regulation of muscle tissue developmentGO:190186310.013
Mouse
type i interferon productionGO:003260620.013
g protein coupled receptor signaling pathwayGO:0007186740.013
regulation of autophagyGO:001050630.013
response to temperature stimulusGO:0009266150.013
cellular response to organic substanceGO:00713101050.013
regulation of heart growthGO:006042020.013
positive regulation of endothelial cell migrationGO:001059520.013
extracellular matrix organizationGO:0030198270.013
regulation of nucleotide metabolic processGO:0006140170.013
renal system processGO:0003014140.013
positive regulation of cellular amino acid metabolic processGO:004576400.012
regulation of rna metabolic processGO:00512522240.012
multicellular organismal metabolic processGO:004423620.012
cerebellar granular layer developmentGO:002168130.012
carboxylic acid biosynthetic processGO:0046394120.012
cellular response to extracellular stimulusGO:003166820.012
regulation of transferase activityGO:0051338160.012
cellular catabolic processGO:0044248270.012
positive regulation of cell fate specificationGO:004266010.012
nitrogen compound transportGO:0071705230.012
ovulation cycleGO:004269820.012
b cell mediated immunityGO:001972430.012
growthGO:00400071740.012
negative regulation of fibroblast growth factor receptor signaling pathwayGO:004003760.012
organism emergence from protective structureGO:007168440.012
positive regulation of neuron deathGO:190121610.012
mononuclear cell proliferationGO:003294310.012
cell morphogenesisGO:00009022890.012
central nervous system developmentGO:00074173870.011
cellular response to chemical stimulusGO:00708871570.011
steroid hormone mediated signaling pathwayGO:004340190.011
regulation of dna replicationGO:000627530.011
negative regulation of map kinase activityGO:004340720.011
rho protein signal transductionGO:000726650.011
adult behaviorGO:003053420.011
cyclic nucleotide metabolic processGO:0009187180.011
cellular macromolecule metabolic processGO:00442603910.011
startle responseGO:000196440.011
multi organism processGO:00517041340.011
positive regulation of striated muscle tissue developmentGO:004584410.011
Mouse
negative regulation of vasculature developmentGO:190134380.011
internal peptidyl lysine acetylationGO:001839320.011
heart field specificationGO:000312810.011
regulation of phosphorylationGO:0042325260.011
wound healingGO:0042060900.011
positive regulation of cell divisionGO:005178120.011
female meiotic divisionGO:000714320.011
single organism organelle organizationGO:19025891990.011
Zebrafish
signal transduction by phosphorylationGO:0023014180.011
regulation of gtpase activityGO:004308720.011
somatic cell dna recombinationGO:001644410.011
protein modification processGO:00362111000.010
glial cell differentiationGO:0010001420.010
cardiac atrium morphogenesisGO:000320920.010
positive regulation of cellular catabolic processGO:003133130.010
cardiocyte differentiationGO:0035051440.010
Zebrafish
macromolecule modificationGO:00434121110.010
embryonic organ morphogenesisGO:00485622740.010
negative regulation of gene expressionGO:0010629650.010
Mouse
cellular response to radiationGO:007147840.010
purine ribonucleotide biosynthetic processGO:0009152200.010
positive regulation of rna biosynthetic processGO:1902680570.010
positive regulation of proteolysisGO:0045862100.010

cx43 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.111
disease of anatomical entityDOID:700.052
Human
physical disorderDOID:008001500.025
musculoskeletal system diseaseDOID:1700.024
Human
osteochondrodysplasiaDOID:225600.019
osteogenesis imperfectaDOID:1234700.019
bone development diseaseDOID:008000600.019
Human
bone diseaseDOID:008000100.019
Human
connective tissue diseaseDOID:6500.019
Human
nervous system diseaseDOID:86300.018
neurodegenerative diseaseDOID:128900.013
central nervous system diseaseDOID:33100.013
dysostosisDOID:193400.010
Human