Danio rerio

47 known processes

npc1

Niemann-Pick disease, type C1

(Aliases: im:7149020,wu:fb53a12,wu:fc29a12)

npc1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
lipid storageGO:001991510.458
cellular protein catabolic processGO:004425740.402
maintenance of locationGO:005123540.399
regulation of metabolic processGO:00192223590.351
hemopoiesisGO:00300971830.348
chordate embryonic developmentGO:00430092710.327
ion transportGO:00068111140.308
synaptic growth at neuromuscular junctionGO:005112420.282
cell morphogenesisGO:00009022890.257
detection of abiotic stimulusGO:0009582240.252
regulation of synapse organizationGO:005080730.252
cellular response to nutrient levelsGO:003166920.245
cellular response to starvationGO:000926710.229
regulation of synapse assemblyGO:005196330.217
regulation of synaptic growth at neuromuscular junctionGO:000858210.215
larval developmentGO:000216420.202
cellular lipid metabolic processGO:0044255360.198
macromolecule biosynthetic processGO:00090592270.198
response to stressGO:00069502630.189
inorganic ion transmembrane transportGO:0098660570.187
autophagyGO:000691440.186
regulation of biological qualityGO:00650082630.170
generation of neuronsGO:00486993850.167
response to abiotic stimulusGO:00096281220.166
response to external stimulusGO:00096052640.147
multicellular organism growthGO:003526440.146
cellular response to extracellular stimulusGO:003166820.144
neuron differentiationGO:00301823530.144
regulation of developmental processGO:00507932470.142
cell projection morphogenesisGO:00488582440.142
regulation of signal transductionGO:00099662250.140
regulation of cell communicationGO:00106462320.139
myeloid cell differentiationGO:0030099860.138
macroautophagyGO:001623610.138
cell projection organizationGO:00300302840.137
signal transductionGO:00071654550.137
regulation of signalingGO:00230512350.131
cellular response to external stimulusGO:007149620.129
neuron projection morphogenesisGO:00488121610.129
regionalizationGO:00030022740.127
regulation of anatomical structure morphogenesisGO:00226031300.126
regulation of multicellular organism growthGO:004001440.124
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.123
single organism metabolic processGO:00447102170.120
blood vessel developmentGO:00015682460.120
regulation of response to stimulusGO:00485832690.118
skeletal system morphogenesisGO:00487051020.117
positive regulation of biological processGO:00485182530.114
response to other organismGO:0051707970.114
sensory perception of chemical stimulusGO:000760630.113
developmental growthGO:00485891660.113
vasculature developmentGO:00019442780.112
regulation of autophagyGO:001050630.110
gene expressionGO:00104672520.109
transportGO:00068102200.109
determination of left right symmetryGO:00073681790.108
organic substance biosynthetic processGO:19015762890.106
urogenital system developmentGO:0001655970.095
apoptotic processGO:00069151160.093
synapse assemblyGO:000741690.093
regulation of protein catabolic processGO:004217610.092
regulation of macromolecule metabolic processGO:00602553170.091
positive regulation of cellular processGO:00485222010.090
p38mapk cascadeGO:003806610.087
tube morphogenesisGO:00352393490.086
central nervous system developmentGO:00074173870.085
system processGO:00030081850.084
proteolysis involved in cellular protein catabolic processGO:005160330.079
negative regulation of biological processGO:00485193040.079
cell part morphogenesisGO:00329902460.077
neuron projection developmentGO:00311751800.077
cellular component assemblyGO:00226071700.076
establishment of localizationGO:00512342440.076
oxoacid metabolic processGO:0043436310.075
proteasomal protein catabolic processGO:001049820.075
cellular component morphogenesisGO:00329893360.075
defense response to gram negative bacteriumGO:005082980.074
intracellular signal transductionGO:0035556850.074
growthGO:00400071740.072
regulation of primary metabolic processGO:00800903110.071
response to carbohydrateGO:000974330.071
positive regulation of cellular catabolic processGO:003133130.070
cognitionGO:005089010.070
positive regulation of cell cycleGO:004578730.069
negative regulation of cellular processGO:00485232830.065
modification dependent macromolecule catabolic processGO:004363230.065
reciprocal meiotic recombinationGO:000713110.065
agingGO:000756820.063
organic cyclic compound metabolic processGO:19013603010.062
regulation of cellular component organizationGO:0051128860.062
regulation of multicellular organismal developmentGO:20000262230.062
response to copper ionGO:0046688130.061
biosynthetic processGO:00090582940.061
cellular macromolecule biosynthetic processGO:00346452240.060
embryonic organ morphogenesisGO:00485622740.060
protein modification processGO:00362111000.060
phosphorylationGO:0016310690.059
ras protein signal transductionGO:000726570.059
angiogenesisGO:00015251580.059
regulation of multicellular organismal processGO:00512392770.059
cell deathGO:00082191210.059
organic substance transportGO:0071702580.058
adult behaviorGO:003053420.058
neuron developmentGO:00486662620.056
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.056
cellular protein modification processGO:00064641000.056
negative regulation of protein phosphorylationGO:000193340.055
macromolecule localizationGO:0033036540.054
cellular response to stressGO:0033554620.054
cellular macromolecule metabolic processGO:00442603910.053
carbohydrate derivative biosynthetic processGO:1901137430.053
regulation of biosynthetic processGO:00098892500.052
negative regulation of protein kinase activityGO:000646940.052
phototransduction visible lightGO:000760320.052
nuclear importGO:005117030.051
multi organism processGO:00517041340.050
regulation of protein targetingGO:190353320.050
inorganic cation transmembrane transportGO:0098662500.050
blood vessel morphogenesisGO:00485142160.050
protein localization to nucleusGO:003450430.049
response to external biotic stimulusGO:0043207970.049
locomotionGO:00400113130.049
macromolecule modificationGO:00434121110.049
multicellular organismal reproductive processGO:0048609350.048
positive regulation of i kappab kinase nf kappab signalingGO:004312330.047
protein metabolic processGO:00195381830.047
nuclear transportGO:005116940.047
regulation of cell shapeGO:000836010.047
cellular nitrogen compound biosynthetic processGO:00442712180.047
i kappab kinase nf kappab signalingGO:000724940.047
synaptic transmission cholinergicGO:000727140.047
head developmentGO:00603223030.047
regulation of nervous system developmentGO:0051960900.046
embryonic skeletal system developmentGO:0048706970.046
g protein coupled receptor signaling pathwayGO:0007186740.045
single organism organelle organizationGO:19025891990.045
cell morphogenesis involved in differentiationGO:00009041950.045
axon developmentGO:00615641660.045
cell growthGO:0016049570.043
renal system developmentGO:0072001940.043
regulation of cellular biosynthetic processGO:00313262450.043
establishment of protein localization to organelleGO:007259440.042
regulation of protein import into nucleusGO:004230620.042
ubiquitin dependent protein catabolic processGO:000651130.042
wnt signaling pathwayGO:0016055800.042
cation transmembrane transportGO:0098655650.041
metal ion transportGO:0030001580.040
embryonic limb morphogenesisGO:003032620.040
positive regulation of cellular component biogenesisGO:004408930.040
carboxylic acid metabolic processGO:0019752220.040
rna metabolic processGO:00160702190.040
negative regulation of epithelial cell proliferationGO:005068010.040
regulation of growthGO:0040008420.040
cell activationGO:0001775160.039
phosphate containing compound metabolic processGO:00067961080.039
negative regulation of sequestering of calcium ionGO:005128340.039
embryonic cranial skeleton morphogenesisGO:0048701900.039
positive regulation of metabolic processGO:00098931080.039
digestive tract developmentGO:00485652650.039
neuron neuron synaptic transmissionGO:000727010.039
response to inorganic substanceGO:0010035380.039
regulation of organ growthGO:004662030.038
nucleic acid metabolic processGO:00903042440.038
digestive system developmentGO:00551232890.038
response to oxygen levelsGO:0070482250.038
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.038
regulation of response to extracellular stimulusGO:003210410.037
embryonic skeletal system morphogenesisGO:0048704930.037
response to biotic stimulusGO:0009607970.036
tissue remodelingGO:004877140.036
response to corticosteroidGO:003196010.036
small molecule metabolic processGO:0044281770.036
programmed cell deathGO:00125011190.036
regulation of phosphate metabolic processGO:0019220430.036
meiotic nuclear divisionGO:000712640.036
camera type eye developmentGO:00430102220.035
detection of external stimulusGO:0009581240.035
meiotic cell cycle processGO:190304630.035
regulation of p38mapk cascadeGO:190074410.035
organic acid metabolic processGO:0006082310.035
phosphorus metabolic processGO:00067931090.034
positive regulation of catabolic processGO:000989640.034
regulation of tube sizeGO:003515020.034
epithelial tube morphogenesisGO:00605621480.033
regulation of intracellular protein transportGO:003315730.033
immune system developmentGO:00025201910.033
reproductive processGO:0022414400.033
regulation of i kappab kinase nf kappab signalingGO:004312240.032
glycoprotein metabolic processGO:0009100230.032
embryo development ending in birth or egg hatchingGO:00097922710.032
positive regulation of apoptotic signaling pathwayGO:200123510.032
regulation of protein localization to nucleusGO:190018020.031
regulation of establishment of protein localizationGO:007020140.031
response to decreased oxygen levelsGO:0036293250.031
fatty acid transportGO:001590810.031
homeostatic processGO:00425921420.030
epibolyGO:0090504410.030
kidney developmentGO:0001822920.030
positive regulation of transportGO:005105020.030
regulation of response to nutrient levelsGO:003210710.029
regulation of receptor recyclingGO:000191930.029
cellular catabolic processGO:0044248270.029
regulation of cell differentiationGO:00455951420.029
positive regulation of response to stimulusGO:0048584800.029
negative regulation of protein localization to nucleusGO:190018120.029
mesenchyme developmentGO:00604851270.029
regulation of dendrite morphogenesisGO:004881430.029
cellular component movementGO:00069283350.029
regulation of cytoplasmic transportGO:190364940.028
eye developmentGO:00016542770.028
response to transition metal nanoparticleGO:1990267280.028
sequestering of calcium ionGO:005120830.028
gastrulationGO:00073692080.028
positive regulation of striated muscle cell differentiationGO:005115510.028
regulation of developmental growthGO:0048638380.028
nucleocytoplasmic transportGO:000691340.028
heterocycle biosynthetic processGO:00181302150.027
regulation of cellular protein catabolic processGO:190336210.027
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.027
sensory perceptionGO:0007600390.027
regulation of cellular metabolic processGO:00313233200.027
heart morphogenesisGO:00030071560.027
regulation of neurogenesisGO:0050767870.027
gland developmentGO:00487321430.027
compound eye developmentGO:004874920.027
dorsal ventral neural tube patterningGO:002190410.026
nitrogen compound metabolic processGO:00068073190.026
cellular response to decreased oxygen levelsGO:003629410.026
cell surface receptor signaling pathwayGO:00071663250.026
sensory organ developmentGO:00074233930.026
immune system processGO:00023762410.026
response to glucocorticoidGO:005138410.026
positive regulation of protein complex assemblyGO:003133420.026
cellular protein metabolic processGO:00442671290.026
regulation of sequestering of calcium ionGO:005128240.026
cell cycle processGO:0022402530.026
periodic partitioningGO:000736510.025
heart developmentGO:00075073130.025
developmental process involved in reproductionGO:0003006270.025
defense response to bacteriumGO:0042742220.025
actin filament based movementGO:003004810.025
negative regulation of catabolic processGO:000989530.025
regulation of photoreceptor cell differentiationGO:004653220.025
protein targeting to nucleusGO:004474430.025
sensory organ morphogenesisGO:00905962000.025
digestive tract morphogenesisGO:00485462310.024
lipid localizationGO:0010876110.024
response to organic substanceGO:00100331530.024
developmental growth involved in morphogenesisGO:0060560860.024
regulation of response to stressGO:0080134360.024
embryonic organ developmentGO:00485683810.024
regulation of cell morphogenesisGO:0022604420.024
establishment of epithelial cell polarityGO:009016220.023
negative regulation of autophagyGO:001050710.023
segment polarity determinationGO:000736710.023
endothelial cell fate commitmentGO:006083930.023
lysosomal transportGO:000704120.023
regulation of localizationGO:00328791040.023
regulation of gene expressionGO:00104682650.022
regulation of synaptic plasticityGO:004816710.022
positive regulation of signalingGO:0023056560.022
somitogenesisGO:0001756870.022
regulation of response to oxidative stressGO:190288220.022
somatic stem cell maintenanceGO:003501910.022
single organism transportGO:00447652060.022
modification dependent protein catabolic processGO:001994130.022
cellular biosynthetic processGO:00442492860.022
response to hexoseGO:000974630.022
negative regulation of protein transportGO:005122430.022
detection of stimulusGO:0051606290.022
connective tissue developmentGO:0061448990.022
single organism nuclear importGO:190259330.022
stem cell maintenanceGO:001982740.022
phototransductionGO:000760220.022
regulation of rho protein signal transductionGO:003502320.022
cytoskeleton dependent cytokinesisGO:006164030.022
positive regulation of cellular amine metabolic processGO:003324000.022
nucleobase containing compound metabolic processGO:00061392740.022
determination of bilateral symmetryGO:00098552040.022
cellular response to light stimulusGO:007148240.021
response to monosaccharideGO:003428430.021
regulation of apoptotic processGO:0042981980.021
exocytosisGO:000688710.021
aromatic compound biosynthetic processGO:00194382170.021
organelle organizationGO:00069962270.021
positive regulation of nitrogen compound metabolic processGO:0051173690.021
neuron projection guidanceGO:0097485860.021
axonogenesisGO:00074091520.021
cellular amino acid metabolic processGO:000652070.021
response to glucoseGO:000974930.020
cell morphogenesis involved in neuron differentiationGO:00486671630.020
protein import into nucleusGO:000660630.020
regulation of dendrite developmentGO:005077330.020
organelle fissionGO:0048285230.020
response to nutrientGO:000758430.020
positive regulation of cell communicationGO:0010647560.020
cell migration involved in gastrulationGO:0042074790.020
single organism reproductive processGO:0044702400.020
cellular response to hypoxiaGO:007145610.020
positive regulation of signal transductionGO:0009967560.020
somite specificationGO:0001757120.019
reproductionGO:0000003400.019
regulation of cell projection organizationGO:0031344440.019
behaviorGO:0007610740.019
small gtpase mediated signal transductionGO:000726480.019
single organism biosynthetic processGO:0044711710.019
centrosome cycleGO:000709810.019
extrinsic apoptotic signaling pathwayGO:009719130.019
synapse organizationGO:0050808210.019
lipid metabolic processGO:0006629520.019
cellular nitrogen compound metabolic processGO:00346412900.019
negative regulation of cell deathGO:0060548600.019
regulation of protein transportGO:005122330.019
myeloid cell homeostasisGO:0002262560.019
nucleic acid templated transcriptionGO:00976591810.019
regulation of cytokine productionGO:000181730.019
rna biosynthetic processGO:00327741810.019
female gamete generationGO:0007292140.019
regulation of heart growthGO:006042020.019
cation transportGO:0006812810.018
deathGO:00162651210.018
regulation of epithelial cell proliferationGO:005067830.018
transition metal ion transportGO:000004160.018
single organism behaviorGO:0044708240.018
regulation of protein ubiquitinationGO:003139630.018
response to nutrient levelsGO:0031667100.018
regulation of nucleotide catabolic processGO:003081120.018
organic cyclic compound biosynthetic processGO:19013622230.018
long chain fatty acid transportGO:001590910.018
response to drugGO:004249330.018
cellular response to drugGO:003569010.018
wound healingGO:0042060900.018
regulation of cell sizeGO:0008361290.018
sexual reproductionGO:0019953360.018
specification of axis polarityGO:006500140.018
cellular ketone metabolic processGO:0042180110.018
post embryonic morphogenesisGO:000988640.018
epithelial cell differentiationGO:00308551160.018
organonitrogen compound metabolic processGO:1901564740.018
cellular aldehyde metabolic processGO:000608140.018
protein importGO:001703830.017
regulation of blood vessel sizeGO:005088020.017
regulation of reactive oxygen species metabolic processGO:200037720.017
regulation of transcription dna templatedGO:00063552130.017
response to antibioticGO:004667710.017
neuronal action potentialGO:0019228180.017
cellular response to oxygen levelsGO:007145310.017
regulation of gtpase activityGO:004308720.017
neural tube patterningGO:0021532330.017
cellular response to radiationGO:007147840.017
cellular macromolecule catabolic processGO:0044265120.017
wnt signaling pathway planar cell polarity pathwayGO:006007140.017
protein complex biogenesisGO:0070271300.017
negative regulation of programmed cell deathGO:0043069580.016
appendage developmentGO:0048736800.016
regulation of cardiac muscle tissue developmentGO:005502410.016
regulation of neuron differentiationGO:0045664560.016
negative regulation of developmental growthGO:004864090.016
myeloid cell developmentGO:0061515320.016
positive regulation of defense response to virus by hostGO:000223000.016
chemical homeostasisGO:0048878490.016
response to starvationGO:004259450.016
cellular component disassemblyGO:002241110.016
positive regulation of blood circulationGO:190352420.016
regulation of establishment of planar polarityGO:009017540.016
pancreas developmentGO:0031016840.016
notch signaling pathwayGO:0007219350.016
cardiac cell fate commitmentGO:006091110.016
fat soluble vitamin metabolic processGO:000677540.016
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217620.016
regulation of embryonic developmentGO:0045995470.015
multicellular organism reproductionGO:0032504350.015
negative regulation of kinase activityGO:003367340.015
stem cell divisionGO:001714510.015
positive regulation of myeloid cell differentiationGO:004563920.015
cation homeostasisGO:0055080330.015
zymogen activationGO:003163830.015
regulation of gtp catabolic processGO:003312420.015
peptidyl serine modificationGO:001820920.015
anterior posterior pattern specificationGO:00099521520.015
b cell differentiationGO:003018310.015
macromolecular complex assemblyGO:0065003350.015
cellular aromatic compound metabolic processGO:00067252950.015
developmental cell growthGO:0048588520.015
sequestering of metal ionGO:005123830.015
rho protein signal transductionGO:000726650.015
cellular amine metabolic processGO:004410620.015
regulation of catalytic activityGO:0050790550.015
regulation of skeletal muscle fiber developmentGO:004874220.015
fat soluble vitamin biosynthetic processGO:004236220.015
tube closureGO:006060610.015
post embryonic organ developmentGO:004856940.015
response to chemicalGO:00422213200.014
segmentationGO:0035282970.014
apoptotic process involved in developmentGO:190274220.014
negative regulation of metabolic processGO:0009892860.014
meiotic chromosome segregationGO:004513230.014
positive regulation of cell divisionGO:005178120.014
amine metabolic processGO:000930820.014
regulation of reproductive processGO:200024140.014
neurological system processGO:0050877620.014
homeostasis of number of cells within a tissueGO:004887340.014
negative regulation of apoptotic processGO:0043066550.014
cytokinesisGO:000091030.014
gamete generationGO:0007276330.014
somite developmentGO:0061053960.014
epithelial cell proliferation involved in liver morphogenesisGO:007257520.014
cell agingGO:000756920.014
regulation of metal ion transportGO:001095940.014
positive regulation of cellular metabolic processGO:0031325940.014
receptor recyclingGO:000188140.014
adherens junction organizationGO:003433240.013
taxisGO:00423301090.013
interaction with hostGO:005170140.013
peptidyl serine phosphorylationGO:001810510.013
neuroblast proliferationGO:000740520.013
detection of temperature stimulusGO:001604800.013
negative regulation of intracellular protein transportGO:009031730.013
regulation of peptidyl tyrosine phosphorylationGO:005073010.013
regulation of protein modification by small protein conjugation or removalGO:190332030.013
regulation of nitrogen compound metabolic processGO:00511712510.013
response to bacteriumGO:0009617580.013
transcription from rna polymerase ii promoterGO:0006366800.013
guanosine containing compound metabolic processGO:190106840.013
embryonic heart tube developmentGO:00350501330.013
embryonic viscerocranium morphogenesisGO:0048703520.013
stem cell proliferationGO:007208940.013
regulation of extrinsic apoptotic signaling pathwayGO:200123630.013
negative regulation of molecular functionGO:0044092230.013
cell death in response to oxidative stressGO:003647320.013
cell cycleGO:0007049930.013
pronephros developmentGO:0048793690.013
proximal distal pattern formationGO:000995410.013
homophilic cell adhesion via plasma membrane adhesion moleculesGO:000715640.013
epithelial cell developmentGO:0002064420.013
regulation of receptor activityGO:001046920.013
transcription dna templatedGO:00063511810.012
regulation of rna metabolic processGO:00512522240.012
response to extracellular stimulusGO:0009991100.012
epiboly involved in gastrulation with mouth forming secondGO:0055113350.012
sensory perception of light stimulusGO:0050953190.012
regulation of protein metabolic processGO:0051246560.012
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.012
primary neural tube formationGO:001402010.012
morphogenesis of an epithelial foldGO:006057110.012
ion homeostasisGO:0050801410.012
regulation of rna biosynthetic processGO:20011412130.012
cytokinetic processGO:003250620.012
regulation of hormone secretionGO:004688320.012
cellular response to toxic substanceGO:009723710.012
single organism intracellular transportGO:1902582250.012
regulation of oxidative stress induced cell deathGO:190320120.012
regulation of cellular ketone metabolic processGO:001056570.012
localization of cellGO:00516742440.012
axis elongationGO:0003401310.012
regulation of wnt signaling pathwayGO:0030111530.012
regulation of molecular functionGO:0065009700.012
cellular response to chemical stimulusGO:00708871570.012
actin mediated cell contractionGO:007025210.012
synaptic transmissionGO:0007268350.012
water homeostasisGO:003010440.012
beta amyloid metabolic processGO:005043510.012
sulfur compound biosynthetic processGO:004427290.012
transmembrane transportGO:00550851200.012

npc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.141
nervous system diseaseDOID:86300.055
muscle tissue diseaseDOID:6600.051
musculoskeletal system diseaseDOID:1700.051
muscular diseaseDOID:008000000.051
myopathyDOID:42300.051
endocrine gland cancerDOID:17000.042
organ system cancerDOID:005068600.042
disease of cellular proliferationDOID:1456600.042
cancerDOID:16200.042
cardiovascular system diseaseDOID:128700.032
cardiomyopathyDOID:005070000.031
intrinsic cardiomyopathyDOID:006003600.031
heart diseaseDOID:11400.031
immune system diseaseDOID:291400.027
integumentary system diseaseDOID:1600.023
brain diseaseDOID:93600.023
central nervous system diseaseDOID:33100.023
disease of metabolismDOID:001466700.019
inherited metabolic disorderDOID:65500.019
thoracic cancerDOID:509300.018
large intestine cancerDOID:567200.018
intestinal cancerDOID:1015500.018
gastrointestinal system cancerDOID:311900.018
lysosomal storage diseaseDOID:321100.016
breast cancerDOID:161200.014
hematopoietic system diseaseDOID:7400.013
colon cancerDOID:21900.013
colorectal cancerDOID:925600.013
colon carcinomaDOID:152000.013
disease of mental healthDOID:15000.013
tauopathyDOID:68000.012
neurodegenerative diseaseDOID:128900.012