Danio rerio

51 known processes

rb1

retinoblastoma 1

(Aliases: zgc:154147)

rb1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.690
embryo development ending in birth or egg hatchingGO:00097922710.300
cellular macromolecule metabolic processGO:00442603910.252
regulation of macromolecule metabolic processGO:00602553170.215
sensory organ morphogenesisGO:00905962000.180
establishment of localizationGO:00512342440.170
cellular nitrogen compound metabolic processGO:00346412900.165
negative regulation of macromolecule metabolic processGO:0010605760.145
cellular macromolecule biosynthetic processGO:00346452240.138
cellular aromatic compound metabolic processGO:00067252950.127
embryonic organ developmentGO:00485683810.127
heterocycle metabolic processGO:00464832900.123
skeletal muscle organ developmentGO:0060538780.120
central nervous system developmentGO:00074173870.119
protein metabolic processGO:00195381830.119
retina layer formationGO:0010842240.116
nitrogen compound metabolic processGO:00068073190.115
organelle assemblyGO:00709251100.114
organic cyclic compound metabolic processGO:19013603010.105
nucleic acid metabolic processGO:00903042440.102
eye morphogenesisGO:00485921440.101
retina morphogenesis in camera type eyeGO:0060042790.097
aromatic compound biosynthetic processGO:00194382170.097
regulation of metabolic processGO:00192223590.096
regulation of cellular metabolic processGO:00313233200.096
retina development in camera type eyeGO:00600411460.095
cellular component morphogenesisGO:00329893360.092
positive regulation of cell cycleGO:004578730.091
meiotic nuclear divisionGO:000712640.089
striated muscle tissue developmentGO:00147061100.089
locomotionGO:00400113130.088
organic substance biosynthetic processGO:19015762890.088
gene expressionGO:00104672520.087
regulation of developmental processGO:00507932470.086
response to chemicalGO:00422213200.086
regulation of cell communicationGO:00106462320.084
eye developmentGO:00016542770.084
negative regulation of biological processGO:00485193040.082
single organism localizationGO:19025782250.082
rna metabolic processGO:00160702190.081
sensory organ developmentGO:00074233930.081
brain developmentGO:00074202930.078
nuclear migrationGO:000709730.076
neural retina developmentGO:0003407490.076
negative regulation of gene expressionGO:0010629650.074
cellular nitrogen compound biosynthetic processGO:00442712180.073
stem cell differentiationGO:00488631170.072
regulation of translational initiationGO:000644610.071
cytoskeleton organizationGO:0007010960.071
chordate embryonic developmentGO:00430092710.070
nucleic acid transportGO:005065720.069
muscle structure developmentGO:00610611960.068
epithelial tube morphogenesisGO:00605621480.067
ion transportGO:00068111140.066
muscle cell developmentGO:00550011150.065
cellular component biogenesisGO:00440851780.064
regulation of multicellular organismal processGO:00512392770.064
regulation of cell differentiationGO:00455951420.064
cell projection organizationGO:00300302840.062
maintenance of locationGO:005123540.062
regulation of nitrogen compound metabolic processGO:00511712510.061
head developmentGO:00603223030.061
rna transportGO:005065820.060
regulation of circadian rhythmGO:004275240.059
signal transductionGO:00071654550.058
nucleocytoplasmic transportGO:000691340.058
transcription dna templatedGO:00063511810.058
cellular localizationGO:0051641970.058
centrosome duplicationGO:005129810.057
muscle tissue developmentGO:00605371100.056
striated muscle cell differentiationGO:00511461290.056
cellular protein modification processGO:00064641000.054
cell deathGO:00082191210.053
transportGO:00068102200.053
tube morphogenesisGO:00352393490.053
single organism transportGO:00447652060.052
regulation of cellular macromolecule biosynthetic processGO:20001122220.050
regulation of biological qualityGO:00650082630.050
protein modification processGO:00362111000.049
camera type eye developmentGO:00430102220.049
regulation of signalingGO:00230512350.049
nucleobase containing compound transportGO:001593120.049
regulation of rna metabolic processGO:00512522240.048
pronuclear migrationGO:003504610.047
striated muscle cell developmentGO:00550021080.047
nucleobase containing compound biosynthetic processGO:00346542050.047
regulation of nucleobase containing compound metabolic processGO:00192192500.046
camera type eye morphogenesisGO:00485931080.046
cellular component assemblyGO:00226071700.046
translational initiationGO:000641330.045
autophagyGO:000691440.045
spindle assemblyGO:005122520.045
cellular component movementGO:00069283350.044
embryonic organ morphogenesisGO:00485622740.044
multi organism processGO:00517041340.044
cell growthGO:0016049570.043
organelle organizationGO:00069962270.043
negative regulation of cellular processGO:00485232830.043
cortical cytoskeleton organizationGO:003086510.043
regulation of gene expressionGO:00104682650.042
regulation of transcription dna templatedGO:00063552130.042
nuclear transportGO:005116940.042
muscle organ developmentGO:00075171010.041
meiotic chromosome segregationGO:004513230.041
skeletal muscle tissue developmentGO:0007519670.041
nuclear exportGO:005116810.041
nucleobase containing compound metabolic processGO:00061392740.041
primary neural tube formationGO:001402010.040
regulation of macromolecule biosynthetic processGO:00105562250.040
posttranscriptional regulation of gene expressionGO:0010608140.039
establishment of rna localizationGO:005123630.039
cellular biosynthetic processGO:00442492860.039
regulation of organelle assemblyGO:190211540.039
organic cyclic compound biosynthetic processGO:19013622230.039
nucleic acid templated transcriptionGO:00976591810.039
regulation of autophagyGO:001050630.039
digestive tract morphogenesisGO:00485462310.038
protein localizationGO:0008104400.038
generation of neuronsGO:00486993850.037
regulation of multicellular organism growthGO:004001440.036
establishment of protein localization to organelleGO:007259440.036
eye photoreceptor cell developmentGO:0042462300.035
cell part morphogenesisGO:00329902460.035
negative regulation of kinase activityGO:003367340.035
microtubule organizing center organizationGO:003102310.035
lipid storageGO:001991510.035
cellular response to chemical stimulusGO:00708871570.035
regulation of biosynthetic processGO:00098892500.034
protein complex localizationGO:003150310.034
negative regulation of protein kinase activityGO:000646940.034
stem cell maintenanceGO:001982740.033
regulation of nucleic acid templated transcriptionGO:19035062130.033
meiotic cell cycle processGO:190304630.033
regulation of cell shapeGO:000836010.032
cell motilityGO:00488702440.032
protein acetylationGO:000647320.032
centrosome cycleGO:000709810.032
muscle fiber developmentGO:0048747520.031
localization of cellGO:00516742440.031
carbohydrate biosynthetic processGO:001605110.031
cellular protein metabolic processGO:00442671290.031
rna export from nucleusGO:000640510.031
regulation of cellular component organizationGO:0051128860.030
cation transportGO:0006812810.030
muscle cell differentiationGO:00426921390.030
cell morphogenesisGO:00009022890.029
myotube cell developmentGO:0014904350.029
cell migrationGO:00164772370.029
macromolecule modificationGO:00434121110.029
cell projection assemblyGO:0030031640.029
negative regulation of metabolic processGO:0009892860.029
regulation of rna biosynthetic processGO:20011412130.029
response to organic substanceGO:00100331530.028
positive regulation of cytoskeleton organizationGO:005149530.028
regulation of stem cell differentiationGO:200073640.028
regulation of multicellular organismal developmentGO:20000262230.028
centrosome organizationGO:005129710.027
regulation of cellular biosynthetic processGO:00313262450.027
negative regulation of mapk cascadeGO:004340940.027
female gonad developmentGO:000858540.027
rna biosynthetic processGO:00327741810.027
negative regulation of protein phosphorylationGO:000193340.027
regulation of protein metabolic processGO:0051246560.027
cell agingGO:000756920.027
regulation of cell developmentGO:00602841000.027
macromolecule localizationGO:0033036540.027
mitotic nuclear divisionGO:0007067180.026
guanosine containing compound catabolic processGO:190106920.026
cellular macromolecular complex assemblyGO:0034622240.026
mesenchymal cell developmentGO:0014031780.026
agingGO:000756820.026
commissural neuron axon guidanceGO:007167930.025
skeletal muscle fiber developmentGO:0048741350.025
ras protein signal transductionGO:000726570.025
heart developmentGO:00075073130.025
digestive system developmentGO:00551232890.025
female sex differentiationGO:004666040.024
positive regulation of cellular component biogenesisGO:004408930.024
heterocycle biosynthetic processGO:00181302150.024
cellular response to oxygen levelsGO:007145310.024
regulation of response to stimulusGO:00485832690.024
response to external stimulusGO:00096052640.024
regulation of metal ion transportGO:001095940.024
morphogenesis of an epitheliumGO:00020093330.023
macromolecule biosynthetic processGO:00090592270.023
neuron differentiationGO:00301823530.023
regulation of sodium ion transportGO:000202820.023
blood vessel morphogenesisGO:00485142160.023
myofibril assemblyGO:0030239480.023
regulation of epithelial to mesenchymal transitionGO:001071730.023
polarized epithelial cell differentiationGO:003085940.023
biosynthetic processGO:00090582940.023
phagocytosisGO:000690930.022
symbiosis encompassing mutualism through parasitismGO:004440340.022
cellular process involved in reproduction in multicellular organismGO:0022412280.022
regulation of cellular amine metabolic processGO:003323800.022
developmental growth involved in morphogenesisGO:0060560860.022
negative regulation of small gtpase mediated signal transductionGO:005105810.022
negative regulation of nitrogen compound metabolic processGO:0051172590.022
single fertilizationGO:000733830.022
cell substrate adhesionGO:003158940.022
stem cell developmentGO:0048864820.022
system processGO:00030081850.022
mesenchyme developmentGO:00604851270.022
regulation of primary metabolic processGO:00800903110.022
rna localizationGO:000640340.021
regulation of microtubule cytoskeleton organizationGO:007050730.021
midbrain developmentGO:0030901280.021
cellular response to external stimulusGO:007149620.021
regulation of cellular ketone metabolic processGO:001056570.021
establishment of localization in cellGO:0051649770.020
regulation of protein complex assemblyGO:004325430.020
lateral inhibitionGO:004633110.020
protein targeting to nucleusGO:004474430.020
positive regulation of transportGO:005105020.020
regulation of synapse organizationGO:005080730.020
negative regulation of developmental processGO:0051093650.020
regulation of localizationGO:00328791040.020
cell cycleGO:0007049930.020
programmed cell deathGO:00125011190.020
cellular response to extracellular stimulusGO:003166820.020
calcium ion importGO:007050940.020
regulation of molecular functionGO:0065009700.020
regulation of cellular protein metabolic processGO:0032268520.020
development of primary female sexual characteristicsGO:004654540.020
meiosis iGO:000712710.020
protein acylationGO:004354330.020
ribosomal small subunit biogenesisGO:004227420.019
regulation of histone h3 k9 methylationGO:005157020.019
notochord developmentGO:0030903540.019
microtubule cytoskeleton organization involved in mitosisGO:190285010.019
regulation of apoptotic processGO:0042981980.019
mesoderm developmentGO:0007498880.019
sprouting angiogenesisGO:0002040530.019
actin filament based processGO:0030029640.019
positive regulation of map kinase activityGO:004340630.019
microtubule based processGO:0007017600.019
protein importGO:001703830.018
regulation of nucleoside metabolic processGO:000911820.018
mrna transportGO:005102820.018
b cell mediated immunityGO:001972430.018
negative regulation of axon extension involved in axon guidanceGO:004884310.018
regulation of transcription from rna polymerase ii promoterGO:00063571140.018
cognitionGO:005089010.018
regulation of protein catabolic processGO:004217610.018
cell morphogenesis involved in differentiationGO:00009041950.018
actin cytoskeleton organizationGO:0030036630.018
entrainment of circadian clockGO:000964920.018
neuronal stem cell maintenanceGO:009715020.018
negative regulation of cell differentiationGO:0045596460.018
regulation of skeletal muscle fiber developmentGO:004874220.018
gtp metabolic processGO:004603940.018
cardiac atrium morphogenesisGO:000320920.018
protein complex biogenesisGO:0070271300.018
gamete generationGO:0007276330.018
cell proliferationGO:0008283800.018
gtp catabolic processGO:000618420.017
dorsal motor nucleus of vagus nerve developmentGO:002174440.017
medulla oblongata developmentGO:002155040.017
cardiac atrium developmentGO:000323040.017
epithelial cell morphogenesisGO:000338220.017
multi organism cellular processGO:004476420.017
blood vessel developmentGO:00015682460.017
single organism metabolic processGO:00447102170.017
cell volume homeostasisGO:000688410.017
ion transmembrane transportGO:0034220910.017
neuron developmentGO:00486662620.017
multicellular organism growthGO:003526440.017
organic acid metabolic processGO:0006082310.017
regulation of nervous system developmentGO:0051960900.017
mitotic dna integrity checkpointGO:004477440.017
regulation of establishment of protein localizationGO:007020140.017
ameboidal type cell migrationGO:00016671430.017
spermatid differentiationGO:004851520.017
cell cycle g1 s phase transitionGO:004484310.017
regulation of mrna processingGO:005068430.017
g1 s transition of mitotic cell cycleGO:000008210.017
cellular component assembly involved in morphogenesisGO:00109271070.017
cellular amino acid metabolic processGO:000652070.017
amine metabolic processGO:000930820.017
purine nucleoside monophosphate catabolic processGO:000912840.016
myotube differentiationGO:0014902450.016
establishment of epithelial cell polarityGO:009016220.016
regulation of synaptic growth at neuromuscular junctionGO:000858210.016
regulation of cell cycleGO:0051726520.016
production of molecular mediator of immune responseGO:000244020.016
heart loopingGO:0001947940.016
response to nitrogen compoundGO:1901698190.016
b cell activationGO:004211320.016
regulation of carbohydrate metabolic processGO:000610940.016
gastrulationGO:00073692080.016
ovulation cycle processGO:002260220.016
transmembrane transportGO:00550851200.016
cell adhesionGO:0007155400.016
carboxylic acid metabolic processGO:0019752220.016
cilium morphogenesisGO:0060271850.016
mitotic cell cycle processGO:1903047480.016
intracellular signal transductionGO:0035556850.016
negative regulation of transcription dna templatedGO:0045892450.016
posttranscriptional gene silencingGO:001644130.016
guanosine containing compound metabolic processGO:190106840.016
regulation of dna templated transcription in response to stressGO:004362000.015
negative regulation of histone modificationGO:003105710.015
single organism organelle organizationGO:19025891990.015
atp catabolic processGO:000620040.015
negative regulation of histone methylationGO:003106110.015
deathGO:00162651210.015
regulation of bindingGO:005109830.015
protein complex assemblyGO:0006461300.015
regulation of dendrite developmentGO:005077330.015
immunoglobulin mediated immune responseGO:001606430.015
rhythmic processGO:0048511210.015
apoptotic processGO:00069151160.015
multicellular organism reproductionGO:0032504350.015
establishment of monopolar cell polarityGO:006116220.015
fertilizationGO:000956630.015
developmental process involved in reproductionGO:0003006270.015
reproductionGO:0000003400.015
eye photoreceptor cell differentiationGO:0001754450.015
cellular carbohydrate metabolic processGO:004426240.014
lateral line system developmentGO:0048925760.014
regulation of neurogenesisGO:0050767870.014
nuclear importGO:005117030.014
positive regulation of nucleoside metabolic processGO:004597910.014
determination of heart left right asymmetryGO:00613711170.014
macromolecular complex subunit organizationGO:0043933740.014
negative regulation of nucleobase containing compound metabolic processGO:0045934590.014
regulation of gene expression epigeneticGO:0040029110.014
synaptic growth at neuromuscular junctionGO:005112420.014
response to amineGO:001407510.014
regulation of establishment of protein localization to plasma membraneGO:009000310.014
reciprocal meiotic recombinationGO:000713110.014
angiogenesisGO:00015251580.014
interspecies interaction between organismsGO:004441940.014
cell morphogenesis involved in neuron differentiationGO:00486671630.014
positive regulation of nucleotide catabolic processGO:003081310.014
regulation of cellular carbohydrate metabolic processGO:001067540.014
photoreceptor cell differentiationGO:0046530550.014
positive regulation of purine nucleotide catabolic processGO:003312310.014
rna 3 end processingGO:003112320.014
negative regulation of rna biosynthetic processGO:1902679450.014
cellular amine metabolic processGO:004410620.014
somitogenesisGO:0001756870.014
cell surface receptor signaling pathwayGO:00071663250.014
regulation of myotube differentiationGO:001083020.014
regulation of purine nucleotide catabolic processGO:003312120.014
axon extensionGO:0048675450.014
posttranscriptional gene silencing by rnaGO:003519430.014
response to external biotic stimulusGO:0043207970.013
regulation of protein bindingGO:004339330.013
regionalizationGO:00030022740.013
extrinsic apoptotic signaling pathwayGO:009719130.013
exocrine system developmentGO:0035272280.013
chromosome segregationGO:0007059120.013
positive regulation of cell substrate adhesionGO:001081110.013
regulation of anatomical structure morphogenesisGO:00226031300.013
growthGO:00400071740.013
homeostatic processGO:00425921420.013
sexual reproductionGO:0019953360.013
intracellular transportGO:0046907320.013
negative regulation of cellular metabolic processGO:0031324770.013
oxoacid metabolic processGO:0043436310.013
dna biosynthetic processGO:007189730.013
spermatid developmentGO:000728620.013
metal ion transportGO:0030001580.013
response to woundingGO:00096111160.013
regulation of protein ubiquitinationGO:003139630.013
response to amino acidGO:004320020.013
regulation of signal transductionGO:00099662250.013
sex determinationGO:000753010.013
regulation of skeletal muscle tissue developmentGO:004864140.013
regulation of cell matrix adhesionGO:000195210.013
developmental growthGO:00485891660.013
transcription from rna polymerase ii promoterGO:0006366800.013
regulation of intracellular signal transductionGO:1902531570.013
facial nerve developmentGO:002156130.013
ovarian follicle developmentGO:000154120.013
cilium organizationGO:0044782710.013
regulation of nucleotide catabolic processGO:003081120.012
cellular response to stressGO:0033554620.012
positive regulation of chromosome organizationGO:200125210.012
regulation of cytoplasmic transportGO:190364940.012
negative regulation of programmed cell deathGO:0043069580.012
heart morphogenesisGO:00030071560.012
retinal ganglion cell axon guidanceGO:0031290350.012
maternal determination of anterior posterior axis embryoGO:000835840.012
cell matrix adhesionGO:000716040.012
developmental cell growthGO:0048588520.012
positive regulation of canonical wnt signaling pathwayGO:009026340.012
cellular response to topologically incorrect proteinGO:003596720.012
negative regulation of catabolic processGO:000989530.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280100.012
positive regulation of catabolic processGO:000989640.012
axonogenesisGO:00074091520.012
mesenchymal cell differentiationGO:0048762870.012
cell substrate junction assemblyGO:000704420.012
proximal distal pattern formationGO:000995410.012
epithelial to mesenchymal transitionGO:0001837210.012
regulation of cell deathGO:00109411030.012
g2 m transition of mitotic cell cycleGO:000008640.012
cell fate commitmentGO:0045165990.012
regulation of gtpase activityGO:004308720.012
cilium assemblyGO:0042384580.012
negative regulation of intracellular signal transductionGO:1902532220.012
response to endogenous stimulusGO:0009719830.012
nuclear pore organizationGO:000699920.012
negative regulation of response to stimulusGO:00485851040.012
adult behaviorGO:003053420.012
reciprocal dna recombinationGO:003582510.012
stem cell proliferationGO:007208940.012
cell migration involved in gastrulationGO:0042074790.012
vasculature developmentGO:00019442780.012
positive regulation of cellular catabolic processGO:003133130.012
regulation of dendrite morphogenesisGO:004881430.012
protein polymerizationGO:005125840.012
neuron projection extensionGO:1990138450.012
regulation of peptidyl tyrosine phosphorylationGO:005073010.012
positive regulation of response to stimulusGO:0048584800.012
cellular ketone metabolic processGO:0042180110.012
positive regulation of cellular processGO:00485222010.011
positive regulation of catalytic activityGO:0043085250.011
regulation of cell morphogenesis involved in differentiationGO:0010769380.011
negative regulation of chemotaxisGO:005092240.011
positive regulation of dna metabolic processGO:005105410.011
regulation of synapse assemblyGO:005196330.011
regulation of peptidase activityGO:0052547230.011
chemotaxisGO:00069351040.011
cellular response to decreased oxygen levelsGO:003629410.011
regulation of wnt signaling pathwayGO:0030111530.011
somite developmentGO:0061053960.011
regulation of establishment of planar polarityGO:009017540.011
ovulation cycleGO:004269820.011
protein import into nucleusGO:000660630.011
regulation of transporter activityGO:003240920.011
regulation of cell substrate adhesionGO:001081010.011
regulation of stem cell proliferationGO:007209120.011
mitotic cell cycleGO:0000278640.011
macromolecular complex assemblyGO:0065003350.011
skeletal system developmentGO:00015011810.011
cellular response to organic substanceGO:00713101050.011
internal peptidyl lysine acetylationGO:001839320.011
protein complex subunit organizationGO:0071822460.011
somatic cell dna recombinationGO:001644410.011
regulation of cell sizeGO:0008361290.011
negative regulation of cellular biosynthetic processGO:0031327550.011
positive regulation of cellular amino acid metabolic processGO:004576400.011
regulation of axon extensionGO:0030516240.011
embryonic skeletal system developmentGO:0048706970.011
regulation of cell activationGO:005086510.011
neurological system processGO:0050877620.011
er nucleus signaling pathwayGO:000698420.011
small molecule metabolic processGO:0044281770.011
establishment of epithelial cell apical basal polarityGO:004519820.011
blood circulationGO:0008015870.011
organic substance transportGO:0071702580.011
response to organic cyclic compoundGO:0014070510.011
regulation of neural precursor cell proliferationGO:200017730.011
lamellipodium assemblyGO:003003210.011
negative regulation of signal transductionGO:0009968940.010
single organism nuclear importGO:190259330.010
endosome to lysosome transportGO:000833310.010
mitochondrial transportGO:000683920.010
mitotic cell cycle embryonicGO:004544820.010
signal transduction by p53 class mediatorGO:0072331130.010
internal protein amino acid acetylationGO:000647520.010
negative regulation of rna metabolic processGO:0051253480.010
cellular response to hypoxiaGO:007145610.010
specification of axis polarityGO:006500140.010
positive regulation of signal transductionGO:0009967560.010
phosphorylationGO:0016310690.010
tube closureGO:006060610.010
positive regulation of epithelial cell migrationGO:001063420.010
positive regulation of gtp catabolic processGO:003312610.010

rb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.097
cancerDOID:16200.032
disease of cellular proliferationDOID:1456600.032
hematopoietic system diseaseDOID:7400.021
immune system diseaseDOID:291400.021
bone marrow diseaseDOID:496100.021
physical disorderDOID:008001500.021
organ system cancerDOID:005068600.020
disease of metabolismDOID:001466700.015
anemiaDOID:235500.015
congenital hypoplastic anemiaDOID:134200.015
aplastic anemiaDOID:1244900.015
muscle tissue diseaseDOID:6600.012
muscular diseaseDOID:008000000.012
musculoskeletal system diseaseDOID:1700.012