Danio rerio

0 known processes

map3k4

mitogen activated protein kinase kinase kinase 4

(Aliases: wu:fc83c01,cb135,mekk4,wu:fa02f11)

map3k4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of biosynthetic processGO:00098892500.368
signal transductionGO:00071654550.352
Human Mouse Fly
nucleic acid metabolic processGO:00903042440.350
Fly
larval developmentGO:000216420.297
nitrogen compound metabolic processGO:00068073190.294
Fly
single organism localizationGO:19025782250.288
Fly
embryo development ending in birth or egg hatchingGO:00097922710.252
regulation of signal transductionGO:00099662250.244
Human Mouse Fly
regulation of macromolecule metabolic processGO:00602553170.231
Human Mouse Fly
protein metabolic processGO:00195381830.214
Human Mouse Fly
nuclear transportGO:005116940.204
negative regulation of cellular processGO:00485232830.197
Fly
generation of neuronsGO:00486993850.197
regulation of cell communicationGO:00106462320.185
Human Mouse Fly
regulation of multicellular organismal processGO:00512392770.179
cell migrationGO:00164772370.178
response to external stimulusGO:00096052640.173
cell surface receptor signaling pathwayGO:00071663250.173
regulation of nucleobase containing compound metabolic processGO:00192192500.171
Fly
positive regulation of signalingGO:0023056560.161
Human Mouse Fly
phosphorus metabolic processGO:00067931090.158
Human Mouse Fly
regulation of response to stimulusGO:00485832690.157
Human Mouse Fly
axon developmentGO:00615641660.156
neuron differentiationGO:00301823530.149
regulation of nitrogen compound metabolic processGO:00511712510.147
Fly
positive regulation of metabolic processGO:00098931080.140
Human Mouse Fly
cellular protein modification processGO:00064641000.137
Human Mouse Fly
gene expressionGO:00104672520.137
Mouse
single organism metabolic processGO:00447102170.125
Human Mouse Fly
organic cyclic compound metabolic processGO:19013603010.122
Fly
regulation of macromolecule biosynthetic processGO:00105562250.122
protein modification processGO:00362111000.120
Human Mouse Fly
localization of cellGO:00516742440.120
negative regulation of biological processGO:00485193040.118
Fly
axonogenesisGO:00074091520.117
modification dependent protein catabolic processGO:001994130.115
cell projection organizationGO:00300302840.111
single organism organelle organizationGO:19025891990.110
cellular protein metabolic processGO:00442671290.110
Human Mouse Fly
protein polyubiquitinationGO:000020940.107
digestive system developmentGO:00551232890.107
negative regulation of response to stimulusGO:00485851040.105
cellular protein catabolic processGO:004425740.105
cellular macromolecule biosynthetic processGO:00346452240.105
negative regulation of signal transductionGO:0009968940.105
cell projection morphogenesisGO:00488582440.104
regulation of neurogenesisGO:0050767870.104
nucleocytoplasmic transportGO:000691340.102
cellular aromatic compound metabolic processGO:00067252950.097
Fly
rna biosynthetic processGO:00327741810.097
cellular nitrogen compound metabolic processGO:00346412900.097
Fly
positive regulation of map kinase activityGO:004340630.094
Human Mouse Fly
neuroblast proliferationGO:000740520.091
adult behaviorGO:003053420.090
regulation of cellular macromolecule biosynthetic processGO:20001122220.090
positive regulation of biological processGO:00485182530.090
Human Mouse Fly
regulation of gene expressionGO:00104682650.089
Mouse
cellular macromolecule metabolic processGO:00442603910.088
Human Mouse Fly
regulation of primary metabolic processGO:00800903110.088
Human Mouse Fly
regulation of developmental processGO:00507932470.086
regulation of signalingGO:00230512350.086
Human Mouse Fly
regionalizationGO:00030022740.084
protein heterooligomerizationGO:005129110.083
heterocycle metabolic processGO:00464832900.080
Fly
establishment of localizationGO:00512342440.078
Fly
negative regulation of collateral sproutingGO:004867120.078
regulation of neuron projection developmentGO:0010975400.078
regulation of cellular metabolic processGO:00313233200.077
Human Mouse Fly
establishment of localization in cellGO:0051649770.076
single organism transportGO:00447652060.076
Fly
cell motilityGO:00488702440.076
ubiquitin dependent protein catabolic processGO:000651130.075
nucleobase containing compound metabolic processGO:00061392740.072
Fly
regulation of metabolic processGO:00192223590.072
Human Mouse Fly
positive regulation of cellular metabolic processGO:0031325940.072
Human Mouse Fly
phagocytosisGO:000690930.070
Fly
regulation of rna biosynthetic processGO:20011412130.068
rna metabolic processGO:00160702190.068
proteolysis involved in cellular protein catabolic processGO:005160330.068
head developmentGO:00603223030.068
heart developmentGO:00075073130.067
oocyte developmentGO:0048599140.066
positive regulation of transportGO:005105020.065
protein localization to nucleusGO:003450430.065
aromatic compound biosynthetic processGO:00194382170.064
brain developmentGO:00074202930.063
regulation of biological qualityGO:00650082630.063
Fly
small molecule metabolic processGO:0044281770.063
cell morphogenesisGO:00009022890.063
biosynthetic processGO:00090582940.063
heart morphogenesisGO:00030071560.062
negative regulation of cell communicationGO:0010648960.061
regulation of cellular biosynthetic processGO:00313262450.060
cellular process involved in reproduction in multicellular organismGO:0022412280.060
positive regulation of catalytic activityGO:0043085250.060
Human Mouse Fly
multicellular organism growthGO:003526440.060
neuron projection developmentGO:00311751800.059
regulation of nucleic acid templated transcriptionGO:19035062130.059
epidermis developmentGO:0008544480.059
regulation of transcription dna templatedGO:00063552130.058
regulation of multicellular organismal developmentGO:20000262230.058
cell cycleGO:0007049930.057
regulation of cell developmentGO:00602841000.055
negative regulation of cytokine mediated signaling pathwayGO:000196020.055
regulation of cell shapeGO:000836010.054
cellular component biogenesisGO:00440851780.054
Fly
organelle organizationGO:00069962270.054
Fly
phosphorylationGO:0016310690.052
Human Mouse Fly
developmental growthGO:00485891660.052
developmental growth involved in morphogenesisGO:0060560860.052
regulation of protein metabolic processGO:0051246560.051
Human Mouse Fly
convergent extensionGO:00600261180.051
regulation of meiotic cell cycleGO:005144510.051
agingGO:000756820.050
stem cell divisionGO:001714510.050
cellular component movementGO:00069283350.050
negative regulation of signalingGO:0023057960.049
positive regulation of catabolic processGO:000989640.049
activation of mapk activityGO:000018730.048
Human Fly
enzyme linked receptor protein signaling pathwayGO:00071671060.048
non canonical wnt signaling pathwayGO:0035567130.047
transportGO:00068102200.047
Fly
positive regulation of macromolecule metabolic processGO:0010604930.047
Human Mouse Fly
axon guidanceGO:0007411860.047
cellular ketone metabolic processGO:0042180110.046
stem cell proliferationGO:007208940.046
cellular localizationGO:0051641970.046
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.046
modification dependent macromolecule catabolic processGO:004363230.046
negative chemotaxisGO:005091910.045
protein dephosphorylationGO:000647030.045
nuclear exportGO:005116810.044
regulation of anatomical structure morphogenesisGO:00226031300.043
regulation of establishment of protein localizationGO:007020140.043
organelle localizationGO:0051640490.043
positive regulation of cell communicationGO:0010647560.043
Human Mouse Fly
cell migration in hindbrainGO:002153570.042
cellular amine metabolic processGO:004410620.042
locomotionGO:00400113130.042
nuclear importGO:005117030.042
organic substance biosynthetic processGO:19015762890.042
regulation of rna metabolic processGO:00512522240.041
growthGO:00400071740.041
regulation of protein transportGO:005122330.041
cellular nitrogen compound biosynthetic processGO:00442712180.041
phosphate containing compound metabolic processGO:00067961080.040
Human Mouse Fly
transcription dna templatedGO:00063511810.040
regulation of protein targetingGO:190353320.039
hindbrain developmentGO:0030902910.039
peptidyl serine phosphorylationGO:001810510.039
regulation of synapse organizationGO:005080730.039
regulation of intracellular protein transportGO:003315730.038
oxoacid metabolic processGO:0043436310.038
cellular biosynthetic processGO:00442492860.038
response to vitaminGO:003327330.038
stem cell maintenanceGO:001982740.038
developmental cell growthGO:0048588520.037
sensory neuron axon guidanceGO:009737430.037
heterocycle biosynthetic processGO:00181302150.037
gastrulationGO:00073692080.036
negative regulation of multicellular organismal processGO:0051241690.036
sexual reproductionGO:0019953360.036
cell part morphogenesisGO:00329902460.036
regulation of glucose importGO:004632410.035
positive regulation of jnk cascadeGO:004633030.035
Human Mouse Fly
positive regulation of cell cycleGO:004578730.035
cell fate commitmentGO:0045165990.035
positive regulation of cellular amino acid metabolic processGO:004576400.035
amine metabolic processGO:000930820.035
regulation of phosphate metabolic processGO:0019220430.035
Human Mouse Fly
cellular response to organic substanceGO:00713101050.034
regulation of cellular ketone metabolic processGO:001056570.034
primary neural tube formationGO:001402010.034
neuron projection morphogenesisGO:00488121610.034
atp catabolic processGO:000620040.034
intracellular signal transductionGO:0035556850.033
Human Mouse Fly
protein import into nucleusGO:000660630.033
positive regulation of molecular functionGO:0044093330.033
Human Mouse Fly
response to carbohydrateGO:000974330.033
regulation of catalytic activityGO:0050790550.033
Human Mouse Fly
regulation of stem cell differentiationGO:200073640.033
regulation of localizationGO:00328791040.033
regulation of cell differentiationGO:00455951420.033
response to nutrientGO:000758430.033
response to organic substanceGO:00100331530.032
multi organism processGO:00517041340.032
regulation of nucleocytoplasmic transportGO:004682220.032
nucleic acid templated transcriptionGO:00976591810.032
positive regulation of signal transductionGO:0009967560.032
Human Mouse Fly
response to uvGO:000941130.032
Human
macromolecule biosynthetic processGO:00090592270.032
synaptic growth at neuromuscular junctionGO:005112420.031
regulation of protein import into nucleusGO:004230620.031
regulation of cellular protein metabolic processGO:0032268520.031
Human Mouse Fly
negative regulation of response to cytokine stimulusGO:006076120.030
skin developmentGO:0043588540.030
maintenance of locationGO:005123540.030
regulation of reproductive processGO:200024140.030
regulation of neuron differentiationGO:0045664560.030
single organism cellular localizationGO:1902580460.030
response to chemicalGO:00422213200.030
Fly
axon cargo transportGO:000808820.029
positive regulation of stress activated mapk cascadeGO:003287430.029
Human Mouse Fly
response to oxygen containing compoundGO:1901700550.029
regulation of nervous system developmentGO:0051960900.028
morphogenesis of an epitheliumGO:00020093330.028
regulation of intracellular signal transductionGO:1902531570.027
Human Mouse Fly
spermatid developmentGO:000728620.027
apoptotic processGO:00069151160.027
Fly
nucleobase containing compound biosynthetic processGO:00346542050.027
positive regulation of cellular amine metabolic processGO:003324000.026
cell cell recognitionGO:000998810.026
deathGO:00162651210.026
Fly
regulation of circadian rhythmGO:004275240.026
single organism nuclear importGO:190259330.026
protein phosphorylationGO:0006468470.026
Human Mouse Fly
regulation of molecular functionGO:0065009700.026
Human Mouse Fly
regulation of dendrite morphogenesisGO:004881430.026
regulation of mitotic cell cycle embryonicGO:000979420.026
maternal determination of anterior posterior axis embryoGO:000835840.025
carboxylic acid metabolic processGO:0019752220.025
programmed cell deathGO:00125011190.025
Fly
cell morphogenesis involved in neuron differentiationGO:00486671630.025
cell substrate adhesionGO:003158940.025
negative regulation of gene expressionGO:0010629650.025
macromolecule modificationGO:00434121110.024
Human Mouse Fly
regulation of dendrite developmentGO:005077330.024
positive regulation of cellular processGO:00485222010.024
Human Mouse Fly
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.024
cellular response to extracellular stimulusGO:003166820.024
cytoskeleton organizationGO:0007010960.024
regulation of phosphorus metabolic processGO:0051174430.023
Human Mouse Fly
regulation of cellular amino acid metabolic processGO:000652100.023
cellular component morphogenesisGO:00329893360.023
neuron migrationGO:0001764220.023
negative regulation of ras protein signal transductionGO:004658010.023
regulation of protein localization to nucleusGO:190018020.023
lipid homeostasisGO:005508830.023
wnt signaling pathwayGO:0016055800.023
mitotic cell cycleGO:0000278640.023
positive regulation of cellular catabolic processGO:003133130.022
hypothalamus cell differentiationGO:002197940.022
regulation of transferase activityGO:0051338160.022
Human Mouse Fly
cellular response to stressGO:0033554620.022
Human Mouse Fly
digestive tract morphogenesisGO:00485462310.022
regulation of multicellular organism growthGO:004001440.022
female sex differentiationGO:004666040.022
hemopoiesisGO:00300971830.021
positive regulation of response to stimulusGO:0048584800.021
Human Mouse Fly
protein targeting to nucleusGO:004474430.021
regulation of cellular component organizationGO:0051128860.021
Fly
microtubule cytoskeleton organizationGO:0000226330.021
regulation of protein catabolic processGO:004217610.021
positive regulation of multicellular organismal processGO:0051240520.021
lipid storageGO:001991510.021
response to stressGO:00069502630.021
Human Mouse Fly
establishment of organelle localizationGO:0051656450.021
regulation of cytoplasmic transportGO:190364940.021
regulation of nucleotide catabolic processGO:003081120.021
homeostatic processGO:00425921420.020
negative regulation of stem cell differentiationGO:200073720.020
organic acid metabolic processGO:0006082310.020
ras protein signal transductionGO:000726570.020
immune system processGO:00023762410.020
Fly
segmentationGO:0035282970.020
neurotransmitter secretionGO:000726920.020
cellular response to nutrient levelsGO:003166920.020
lamellipodium organizationGO:009758110.020
regulation of wnt signaling pathwayGO:0030111530.019
cell proliferationGO:0008283800.019
anatomical structure arrangementGO:004853220.019
organic substance transportGO:0071702580.019
vascular endothelial growth factor signaling pathwayGO:003808430.019
lamellipodium assemblyGO:003003210.019
pancreas developmentGO:0031016840.019
cell morphogenesis involved in differentiationGO:00009041950.019
cellular response to starvationGO:000926710.019
regulation of microtubule cytoskeleton organizationGO:007050730.019
negative regulation of protein complex assemblyGO:003133310.018
gland developmentGO:00487321430.018
cellular response to chemical stimulusGO:00708871570.018
Fly
meiotic nuclear divisionGO:000712640.017
gtp catabolic processGO:000618420.017
negative regulation of neuron projection regenerationGO:007057140.017
mapk cascadeGO:0000165180.017
Human Mouse Fly
digestive tract developmentGO:00485652650.017
carbohydrate homeostasisGO:003350010.017
homeostasis of number of cellsGO:0048872620.017
circadian sleep wake cycle sleepGO:005080210.017
central nervous system developmentGO:00074173870.017
regulation of proteolysisGO:0030162240.017
negative regulation of nucleocytoplasmic transportGO:004682320.017
establishment or maintenance of cell polarityGO:0007163290.017
response to ketoneGO:190165410.016
regulation of cellular amine metabolic processGO:003323800.016
metencephalon developmentGO:0022037270.016
regulation of glucose transportGO:001082710.016
negative regulation of translationGO:001714810.016
regulation of mrna splicing via spliceosomeGO:004802430.016
convergent extension involved in gastrulationGO:0060027710.016
cell growthGO:0016049570.016
rna 3 end processingGO:003112320.016
cellular component disassemblyGO:002241110.016
dna templated transcription elongationGO:000635430.016
cell cycle processGO:0022402530.015
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.015
chromosome organizationGO:0051276310.015
Fly
establishment of apical basal cell polarityGO:003508920.015
microtubule based movementGO:0007018330.015
embryonic skeletal joint developmentGO:007249830.015
response to abiotic stimulusGO:00096281220.015
Human Fly
positive regulation of developmental processGO:0051094500.015
positive regulation of jun kinase activityGO:004350720.015
Human Mouse
oocyte anterior posterior axis specificationGO:000731440.015
female gonad developmentGO:000858540.015
regulation of protein polymerizationGO:003227120.015
development of primary female sexual characteristicsGO:004654540.015
negative regulation of collateral sprouting of intact axon in response to injuryGO:004868520.015
regulation of cell morphogenesisGO:0022604420.015
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.015
catabolic processGO:0009056320.014
cellular response to endogenous stimulusGO:0071495680.014
protein polymerizationGO:005125840.014
negative regulation of small gtpase mediated signal transductionGO:005105810.014
regulation of protein complex assemblyGO:004325430.014
rna localizationGO:000640340.014
cellular amino acid metabolic processGO:000652070.014
establishment of protein localization to organelleGO:007259440.014
establishment of mitotic spindle localizationGO:0040001120.014
autophagyGO:000691440.014
regulation of smoothened signaling pathwayGO:0008589180.014
negative regulation of dna recombinationGO:004591020.014
chemotaxisGO:00069351040.014
dna biosynthetic processGO:007189730.014
spermatid differentiationGO:004851520.014
metal ion transportGO:0030001580.014
regulation of response to stressGO:0080134360.014
Human Mouse Fly
tissue remodelingGO:004877140.014
cellular response to oxygen containing compoundGO:1901701200.014
anterior posterior pattern specificationGO:00099521520.013
polarized epithelial cell differentiationGO:003085940.013
regulation of response to nutrient levelsGO:003210710.013
negative regulation of metabolic processGO:0009892860.013
Fly
negative regulation of catabolic processGO:000989530.013
regulation of nucleoside metabolic processGO:000911820.013
negative regulation of cellular metabolic processGO:0031324770.013
Fly
embryonic organ morphogenesisGO:00485622740.013
response to hormoneGO:0009725480.013
regulation of cell projection organizationGO:0031344440.013
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.013
Human Mouse Fly
vasculature developmentGO:00019442780.013
regulation of programmed cell deathGO:00430671010.012
regulation of phosphorylationGO:0042325260.012
Human Mouse Fly
negative regulation of intracellular transportGO:003238730.012
sympathetic ganglion developmentGO:006154920.012
regulation of response to cytokine stimulusGO:006075930.012
production of molecular mediator of immune responseGO:000244020.012
epithelial tube morphogenesisGO:00605621480.012
synaptic target recognitionGO:000803910.012
regulation of kinase activityGO:0043549150.012
Human Mouse Fly
establishment or maintenance of bipolar cell polarityGO:0061245120.012
smoothened signaling pathwayGO:0007224300.012
negative regulation of defense responseGO:003134820.012
cellular macromolecule localizationGO:0070727210.012
positive regulation of carbohydrate metabolic processGO:004591310.012
response to endogenous stimulusGO:0009719830.012
reproductionGO:0000003400.012
cardiac cell fate commitmentGO:006091110.012
mitochondrion organizationGO:000700540.012
oogenesisGO:0048477140.012
regulation of collateral sprouting of intact axon in response to injuryGO:004868320.012
negative regulation of cellular component organizationGO:0051129160.012
Fly
neuron developmentGO:00486662620.011
determination of left right symmetryGO:00073681790.011
regulation of cell motilityGO:2000145460.011
regulation of rho protein signal transductionGO:003502320.011
viral processGO:001603210.011
peptidyl threonine phosphorylationGO:001810710.011
muscle cell differentiationGO:00426921390.011
lipid metabolic processGO:0006629520.011
protein complex disassemblyGO:004324110.011
regulation of mrna processingGO:005068430.011
regulation of protein phosphorylationGO:0001932180.011
Human Mouse Fly
regulation of cytokine mediated signaling pathwayGO:000195930.011
mrna 3 end processingGO:003112420.011
establishment or maintenance of epithelial cell apical basal polarityGO:0045197110.011
organonitrogen compound metabolic processGO:1901564740.011
positive regulation of phosphate metabolic processGO:0045937210.011
Human Mouse Fly
single organism reproductive processGO:0044702400.011
Mouse
regulation of cytokine productionGO:000181730.011
multicellular organism reproductionGO:0032504350.011
dsrna fragmentationGO:003105010.011
regulation of translational initiationGO:000644610.011
meiosis iGO:000712710.011
positive regulation of protein kinase b signalingGO:005189710.011
cilium morphogenesisGO:0060271850.011
angiogenesisGO:00015251580.011
cellular response to external stimulusGO:007149620.011
cell recognitionGO:0008037190.011
germ line stem cell divisionGO:004207810.011
regulation of system processGO:0044057400.011
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
negative regulation of multi organism processGO:004390130.010
positive regulation of phosphorus metabolic processGO:0010562210.010
Human Mouse Fly
synaptic vesicle transportGO:004848910.010
positive regulation of intracellular signal transductionGO:1902533150.010
Human Mouse Fly
proteasomal protein catabolic processGO:001049820.010
macromolecule localizationGO:0033036540.010
regulation of gtpase activityGO:004308720.010
rna processingGO:0006396250.010
neural tube developmentGO:0021915620.010
embryonic heart tube morphogenesisGO:00031431080.010
neural precursor cell proliferationGO:0061351200.010
establishment or maintenance of monopolar cell polarityGO:006133920.010
heart contractionGO:0060047710.010
embryonic pattern specificationGO:0009880440.010
embryonic organ developmentGO:00485683810.010
larval heart developmentGO:000750820.010
positive regulation of biosynthetic processGO:0009891680.010
regulation of cell matrix adhesionGO:000195210.010
reproductive processGO:0022414400.010
Mouse
positive regulation of cell adhesionGO:004578510.010
protein complex subunit organizationGO:0071822460.010
specification of symmetryGO:00097992040.010
negative regulation of macromolecule metabolic processGO:0010605760.010
Fly
neuron projection regenerationGO:0031102160.010
mitotic g2 dna damage checkpointGO:000709530.010
regulation of anatomical structure sizeGO:0090066330.010
Fly
establishment of mitotic spindle orientationGO:0000132100.010
cell agingGO:000756920.010
pons developmentGO:0021548110.010

map3k4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.021
cancerDOID:16200.021
organ system cancerDOID:005068600.021
disease of anatomical entityDOID:700.017
nervous system diseaseDOID:86300.014
brain diseaseDOID:93600.011
epilepsy syndromeDOID:182600.011
central nervous system diseaseDOID:33100.011