Danio rerio

33 known processes

optn

optineurin

(Aliases: wu:fj52f04,fj52f04,MGC66386,si:ch211-240l19.3,zgc:66386,zgc:77868)

optn biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cellular metabolic processGO:00313233200.200
agingGO:000756820.144
regulation of metabolic processGO:00192223590.138
modification dependent protein catabolic processGO:001994130.108
regulation of cytokine productionGO:000181730.106
lipid storageGO:001991510.102
maintenance of locationGO:005123540.099
regulation of signalingGO:00230512350.078
Zebrafish
symbiosis encompassing mutualism through parasitismGO:004440340.075
cellular macromolecule metabolic processGO:00442603910.075
Zebrafish
hemopoiesisGO:00300971830.075
negative regulation of biological processGO:00485193040.069
proteolysis involved in cellular protein catabolic processGO:005160330.069
signal transductionGO:00071654550.066
Zebrafish
regulation of cellular biosynthetic processGO:00313262450.065
cellular protein catabolic processGO:004425740.063
regulation of signal transductionGO:00099662250.063
Zebrafish
establishment of localization in cellGO:0051649770.060
negative regulation of protein transportGO:005122430.058
endosomal transportGO:001619720.056
negative regulation of cytoplasmic transportGO:190365020.056
regulation of primary metabolic processGO:00800903110.055
regulation of response to stimulusGO:00485832690.053
Zebrafish
i kappab kinase nf kappab signalingGO:000724940.051
Zebrafish
regionalizationGO:00030022740.050
establishment of protein localization to organelleGO:007259440.049
regulation of macromolecule metabolic processGO:00602553170.049
larval developmentGO:000216420.046
transportGO:00068102200.046
modification dependent macromolecule catabolic processGO:004363230.045
embryonic organ developmentGO:00485683810.043
protein metabolic processGO:00195381830.043
Zebrafish
single organism transportGO:00447652060.043
interspecies interaction between organismsGO:004441940.041
regulation of rna biosynthetic processGO:20011412130.041
oxalate transportGO:001953210.040
endosome to lysosome transportGO:000833310.040
regulation of cell communicationGO:00106462320.040
Zebrafish
synaptic transmission cholinergicGO:000727140.039
regulation of intracellular signal transductionGO:1902531570.037
Zebrafish
synaptic vesicle transportGO:004848910.037
establishment of localizationGO:00512342440.036
central nervous system developmentGO:00074173870.036
proteasomal protein catabolic processGO:001049820.036
autophagyGO:000691440.035
nuclear transportGO:005116940.035
immune system processGO:00023762410.034
regulation of nucleic acid templated transcriptionGO:19035062130.033
negative regulation of nucleocytoplasmic transportGO:004682320.033
nitrogen compound metabolic processGO:00068073190.033
regulation of biosynthetic processGO:00098892500.031
vacuolar transportGO:000703420.030
gene expressionGO:00104672520.030
axonogenesisGO:00074091520.030
regulation of gene expressionGO:00104682650.029
interaction with hostGO:005170140.029
intracellular signal transductionGO:0035556850.028
Zebrafish
single organism localizationGO:19025782250.028
nucleobase containing compound metabolic processGO:00061392740.028
organic substance biosynthetic processGO:19015762890.028
ubiquitin dependent protein catabolic processGO:000651130.028
protein importGO:001703830.028
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.027
cellular protein metabolic processGO:00442671290.027
Zebrafish
biosynthetic processGO:00090582940.027
positive regulation of metabolic processGO:00098931080.027
cellular lipid catabolic processGO:004424230.027
cellular aromatic compound metabolic processGO:00067252950.027
heterocycle metabolic processGO:00464832900.027
locomotionGO:00400113130.026
nucleic acid metabolic processGO:00903042440.026
single organism metabolic processGO:00447102170.026
regulation of protein catabolic processGO:004217610.026
negative regulation of signalingGO:0023057960.025
nucleocytoplasmic transportGO:000691340.025
response to chemicalGO:00422213200.025
heterocycle biosynthetic processGO:00181302150.025
response to stressGO:00069502630.025
rna metabolic processGO:00160702190.025
regulation of macromolecule biosynthetic processGO:00105562250.025
regulation of nitrogen compound metabolic processGO:00511712510.024
regulation of cellular ketone metabolic processGO:001056570.024
negative regulation of cytokine productionGO:000181810.024
aromatic compound biosynthetic processGO:00194382170.024
negative regulation of intracellular protein transportGO:009031730.024
regulation of protein import into nucleusGO:004230620.023
regulation of response to stressGO:0080134360.023
cellular response to starvationGO:000926710.023
hindbrain developmentGO:0030902910.022
guanosine containing compound catabolic processGO:190106920.022
meiotic nuclear divisionGO:000712640.022
cellular localizationGO:0051641970.022
tube morphogenesisGO:00352393490.021
lysosomal transportGO:000704120.021
multicellular organism growthGO:003526440.021
cellular nitrogen compound metabolic processGO:00346412900.021
positive regulation of biological processGO:00485182530.021
Zebrafish
morphogenesis of an epitheliumGO:00020093330.020
cellular amino acid metabolic processGO:000652070.020
guanosine containing compound metabolic processGO:190106840.020
transcription dna templatedGO:00063511810.020
lipid catabolic processGO:001604240.020
protein import into nucleusGO:000660630.020
cellular component morphogenesisGO:00329893360.020
cellular amine metabolic processGO:004410620.020
negative regulation of protein localization to nucleusGO:190018120.020
regulation of reproductive processGO:200024140.020
exocytosisGO:000688710.020
protein targeting to nucleusGO:004474430.020
regulation of nucleobase containing compound metabolic processGO:00192192500.020
cell motilityGO:00488702440.019
regulation of cellular macromolecule biosynthetic processGO:20001122220.019
organic cyclic compound biosynthetic processGO:19013622230.019
positive regulation of signal transductionGO:0009967560.019
Zebrafish
regulation of neurotransmitter transportGO:005158810.019
regulation of i kappab kinase nf kappab signalingGO:004312240.019
Zebrafish
regulation of transcription dna templatedGO:00063552130.019
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.018
cellular response to molecule of bacterial originGO:007121930.018
positive regulation of transportGO:005105020.018
tissue remodelingGO:004877140.018
negative regulation of protein kinase activityGO:000646940.018
brain developmentGO:00074202930.018
negative regulation of kinase activityGO:003367340.018
positive regulation of immune effector processGO:000269930.018
multi organism cellular processGO:004476420.018
regulation of biological qualityGO:00650082630.018
organic cyclic compound metabolic processGO:19013603010.018
lytic vacuole organizationGO:008017110.018
nucleobase containing compound biosynthetic processGO:00346542050.017
regulation of p38mapk cascadeGO:190074410.017
negative regulation of cell communicationGO:0010648960.017
regulation of protein transportGO:005122330.017
cell surface receptor signaling pathwayGO:00071663250.017
synaptic vesicle localizationGO:009747910.017
head developmentGO:00603223030.017
negative regulation of cellular processGO:00485232830.017
macromolecule biosynthetic processGO:00090592270.017
regulation of cellular amine metabolic processGO:003323800.017
cellular ketone metabolic processGO:0042180110.017
macroautophagyGO:001623610.017
membrane invaginationGO:001032410.017
hematopoietic or lymphoid organ developmentGO:00485341910.017
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.017
positive regulation of catabolic processGO:000989640.017
macromolecule localizationGO:0033036540.017
cellular response to external stimulusGO:007149620.016
cellular response to nutrient levelsGO:003166920.016
camera type eye developmentGO:00430102220.016
single organism intracellular transportGO:1902582250.016
organelle organizationGO:00069962270.016
negative regulation of protein phosphorylationGO:000193340.016
establishment of synaptic vesicle localizationGO:009748010.016
organelle fusionGO:004828430.016
regulation of cellular amino acid metabolic processGO:000652100.016
regulation of production of molecular mediator of immune responseGO:000270010.016
positive regulation of jnk cascadeGO:004633030.016
small molecule metabolic processGO:0044281770.016
cellular nitrogen compound biosynthetic processGO:00442712180.016
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.016
cellular component movementGO:00069283350.016
intracellular receptor signaling pathwayGO:0030522300.016
cellular macromolecule biosynthetic processGO:00346452240.016
multicellular organismal macromolecule metabolic processGO:004425920.015
regulation of protein metabolic processGO:0051246560.015
response to abiotic stimulusGO:00096281220.015
regulation of response to oxidative stressGO:190288220.015
positive regulation of cytokine productionGO:000181920.015
skeletal system morphogenesisGO:00487051020.015
carboxylic acid metabolic processGO:0019752220.015
carboxylic acid catabolic processGO:004639530.015
regulation of protein localization to nucleusGO:190018020.015
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.015
intracellular transportGO:0046907320.015
positive regulation of response to stimulusGO:0048584800.015
Zebrafish
negative regulation of signal transductionGO:0009968940.015
protein complex localizationGO:003150310.015
response to organic substanceGO:00100331530.014
cellular monovalent inorganic cation homeostasisGO:003000420.014
positive regulation of stress activated mapk cascadeGO:003287430.014
regulation of tube sizeGO:003515020.014
single organism nuclear importGO:190259330.014
organonitrogen compound metabolic processGO:1901564740.014
rna biosynthetic processGO:00327741810.014
centrosome organizationGO:005129710.014
lymphocyte proliferationGO:004665110.014
deathGO:00162651210.014
muscle tissue developmentGO:00605371100.014
cell killingGO:000190620.014
generation of neuronsGO:00486993850.014
chordate embryonic developmentGO:00430092710.014
neuron projection developmentGO:00311751800.014
positive regulation of signalingGO:0023056560.014
Zebrafish
axon developmentGO:00615641660.014
negative regulation of i kappab kinase nf kappab signalingGO:004312410.014
cellular response to chemical stimulusGO:00708871570.014
skeletal system developmentGO:00015011810.014
embryonic heart tube developmentGO:00350501330.014
regulation of protein targetingGO:190353320.014
regulation of intracellular protein transportGO:003315730.014
notochord developmentGO:0030903540.014
negative regulation of protein import into nucleusGO:004230820.014
immune responseGO:0006955280.013
cellular biosynthetic processGO:00442492860.013
cytoskeleton dependent cytokinesisGO:006164030.013
positive regulation of cellular catabolic processGO:003133130.013
p38mapk cascadeGO:003806610.013
organic acid metabolic processGO:0006082310.013
neurotransmitter transportGO:000683620.013
protein localization to nucleusGO:003450430.013
regulation of rna metabolic processGO:00512522240.013
localization of cellGO:00516742440.013
extrinsic apoptotic signaling pathwayGO:009719130.013
embryonic skeletal system morphogenesisGO:0048704930.013
positive regulation of cellular metabolic processGO:0031325940.013
regulation of synaptic growth at neuromuscular junctionGO:000858210.013
regulation of cytokine biosynthetic processGO:004203510.013
protein localization to plasma membraneGO:007265910.012
neutrophil migrationGO:1990266100.012
medulla oblongata developmentGO:002155040.012
macromolecule modificationGO:00434121110.012
Zebrafish
embryonic organ morphogenesisGO:00485622740.012
regulation of cytoplasmic transportGO:190364940.012
phagocytosisGO:000690930.012
growthGO:00400071740.012
organic acid catabolic processGO:001605430.012
peptide metabolic processGO:000651810.012
cellular response to biotic stimulusGO:007121630.012
cellular response to extracellular stimulusGO:003166820.012
gtp metabolic processGO:004603940.012
regulation of nucleocytoplasmic transportGO:004682220.012
regulation of synapse assemblyGO:005196330.012
embryonic skeletal system developmentGO:0048706970.012
immune system developmentGO:00025201910.012
sensory perception of chemical stimulusGO:000760630.012
amide biosynthetic processGO:004360410.012
negative regulation of intracellular transportGO:003238730.011
positive regulation of cell killingGO:003134320.011
adult behaviorGO:003053420.011
regulation of protein complex assemblyGO:004325430.011
inositol lipid mediated signalingGO:004801720.011
regulation of cell developmentGO:00602841000.011
golgi vesicle transportGO:004819330.011
homeostasis of number of cells within a tissueGO:004887340.011
regulation of catalytic activityGO:0050790550.011
collagen metabolic processGO:003296320.011
fatty acid transportGO:001590810.011
small molecule catabolic processGO:004428230.011
phosphorylationGO:0016310690.011
Zebrafish
positive regulation of secretionGO:005104710.011
regulation of cell projection assemblyGO:006049140.011
regulation of phGO:000688530.011
phosphate containing compound metabolic processGO:00067961080.011
Zebrafish
regulation of lipid transportGO:003236840.011
membrane fusionGO:006102520.011
cell morphogenesis involved in neuron differentiationGO:00486671630.011
intestinal cholesterol absorptionGO:003029920.011
cellular amide metabolic processGO:004360340.011
leukocyte mediated cytotoxicityGO:000190910.011
nuclear importGO:005117030.011
transcription from rna polymerase ii promoterGO:0006366800.011
cell morphogenesis involved in differentiationGO:00009041950.011
response to alkaloidGO:004327920.011
neutrophil mediated immunityGO:000244610.010
peptide transportGO:001583310.010
response to hydrogen peroxideGO:004254230.010
neuron projection morphogenesisGO:00488121610.010
nuclear exportGO:005116810.010
cell projection morphogenesisGO:00488582440.010
oxoacid metabolic processGO:0043436310.010
regulation of stem cell differentiationGO:200073640.010
long chain fatty acid metabolic processGO:000167610.010
regulation of neurotransmitter secretionGO:004692810.010

optn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.029
immune system diseaseDOID:291400.020
nervous system diseaseDOID:86300.018
cancerDOID:16200.012
disease of cellular proliferationDOID:1456600.012
disease of metabolismDOID:001466700.011