Danio rerio

16 known processes

dio2

deiodinase, iodothyronine, type II

(Aliases: Deio2,cb684)

dio2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
carboxylic acid metabolic processGO:0019752220.231
multicellular organism growthGO:003526440.179
ovulation cycle processGO:002260220.168
cell surface receptor signaling pathwayGO:00071663250.168
immune system processGO:00023762410.154
transcription from rna polymerase ii promoterGO:0006366800.153
cognitionGO:005089010.149
gene expressionGO:00104672520.146
maintenance of locationGO:005123540.146
cellular aromatic compound metabolic processGO:00067252950.142
response to endogenous stimulusGO:0009719830.127
negative regulation of cellular processGO:00485232830.118
female sex differentiationGO:004666040.114
intracellular estrogen receptor signaling pathwayGO:003052030.113
determination of bilateral symmetryGO:00098552040.113
nitrogen compound metabolic processGO:00068073190.108
ovulation cycleGO:004269820.104
larval developmentGO:000216420.103
negative regulation of neural precursor cell proliferationGO:200017810.101
g protein coupled receptor signaling pathwayGO:0007186740.100
cell proliferationGO:0008283800.100
oxoacid metabolic processGO:0043436310.100
single organism metabolic processGO:00447102170.096
regulation of stem cell proliferationGO:007209120.096
muscle cell developmentGO:00550011150.095
cellular response to chemical stimulusGO:00708871570.095
negative regulation of cell deathGO:0060548600.095
agingGO:000756820.088
negative regulation of response to stimulusGO:00485851040.086
macromolecule biosynthetic processGO:00090592270.086
response to amphetamineGO:000197510.084
organic cyclic compound metabolic processGO:19013603010.084
response to amineGO:001407510.084
regulation of systemic arterial blood pressureGO:000307310.084
cellular component morphogenesisGO:00329893360.080
organic acid metabolic processGO:0006082310.079
cellular nitrogen compound biosynthetic processGO:00442712180.078
fertilizationGO:000956630.075
regulation of primary metabolic processGO:00800903110.072
myofibril assemblyGO:0030239480.072
biosynthetic processGO:00090582940.070
intracellular receptor signaling pathwayGO:0030522300.068
erk1 and erk2 cascadeGO:007037140.065
positive regulation of erk1 and erk2 cascadeGO:007037420.064
small molecule metabolic processGO:0044281770.063
regulation of lipid catabolic processGO:005099420.063
cell projection morphogenesisGO:00488582440.062
nuclear transportGO:005116940.060
signal transductionGO:00071654550.059
response to external stimulusGO:00096052640.059
regulation of rna metabolic processGO:00512522240.058
regulation of erk1 and erk2 cascadeGO:007037240.057
striated muscle cell developmentGO:00550021080.056
nucleic acid metabolic processGO:00903042440.056
regulation of multicellular organism growthGO:004001440.055
regulation of nitrogen compound metabolic processGO:00511712510.054
cellular macromolecule metabolic processGO:00442603910.054
small molecule biosynthetic processGO:0044283160.054
striated muscle tissue developmentGO:00147061100.052
stem cell proliferationGO:007208940.050
positive regulation of biological processGO:00485182530.050
response to organic substanceGO:00100331530.049
cellular response to organic substanceGO:00713101050.049
embryonic organ developmentGO:00485683810.049
regulation of macromolecule biosynthetic processGO:00105562250.048
organic substance biosynthetic processGO:19015762890.048
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.045
regulation of immune system processGO:0002682340.044
energy reserve metabolic processGO:000611220.042
heterocycle metabolic processGO:00464832900.042
regulation of establishment of protein localizationGO:007020140.041
response to chemicalGO:00422213200.041
positive regulation of catabolic processGO:000989640.041
cellular component assembly involved in morphogenesisGO:00109271070.041
hematopoietic or lymphoid organ developmentGO:00485341910.040
pigmentationGO:0043473850.040
regulation of cellular metabolic processGO:00313233200.040
posterior lateral line neuromast primordium migrationGO:0048920120.040
monoamine transportGO:001584410.039
regulation of anatomical structure morphogenesisGO:00226031300.038
cellular macromolecule biosynthetic processGO:00346452240.038
regulation of developmental processGO:00507932470.038
digestive tract morphogenesisGO:00485462310.038
negative regulation of camp metabolic processGO:003081570.038
regulation of cell deathGO:00109411030.037
regulation of nucleobase containing compound metabolic processGO:00192192500.037
heart developmentGO:00075073130.037
brain developmentGO:00074202930.037
regulation of multicellular organismal developmentGO:20000262230.036
growthGO:00400071740.036
monocarboxylic acid biosynthetic processGO:0072330120.036
nucleic acid templated transcriptionGO:00976591810.035
immune system developmentGO:00025201910.035
regulation of cellular biosynthetic processGO:00313262450.035
apoptotic processGO:00069151160.035
regulation of lyase activityGO:0051339120.035
negative regulation of kinase activityGO:003367340.035
gabaergic neuron differentiationGO:009715420.034
single organism transportGO:00447652060.034
response to foodGO:003209410.034
regulation of programmed cell deathGO:00430671010.034
gland developmentGO:00487321430.034
multicellular organismal response to stressGO:003355520.034
regulation of macromolecule metabolic processGO:00602553170.033
regulation of cyclase activityGO:0031279120.033
single organism localizationGO:19025782250.033
organonitrogen compound metabolic processGO:1901564740.033
response to oxygen levelsGO:0070482250.033
embryo development ending in birth or egg hatchingGO:00097922710.033
cellular amine metabolic processGO:004410620.033
cellular response to hormone stimulusGO:0032870390.032
response to acid chemicalGO:0001101170.032
cellular nitrogen compound metabolic processGO:00346412900.031
organic cyclic compound biosynthetic processGO:19013622230.031
cytokinesisGO:000091030.031
purine containing compound biosynthetic processGO:0072522200.031
development of primary female sexual characteristicsGO:004654540.030
cellular response to estradiol stimulusGO:007139210.030
developmental programmed cell deathGO:001062340.029
phagocytosisGO:000690930.029
chemosensory behaviorGO:000763510.028
regulation of cell activationGO:005086510.028
cellular modified amino acid metabolic processGO:000657530.027
response to nitrogen compoundGO:1901698190.027
rna metabolic processGO:00160702190.027
specification of symmetryGO:00097992040.027
regulation of neural precursor cell proliferationGO:200017730.027
cellular amino acid metabolic processGO:000652070.026
neuron developmentGO:00486662620.026
cellular response to endogenous stimulusGO:0071495680.026
system processGO:00030081850.026
regulation of cell proliferationGO:0042127370.026
positive regulation of transcription dna templatedGO:0045893570.026
carboxylic acid biosynthetic processGO:0046394120.026
negative regulation of defense responseGO:003134820.025
ovarian follicle developmentGO:000154120.025
cell part morphogenesisGO:00329902460.024
regulation of circadian rhythmGO:004275240.024
endocrine system developmentGO:0035270650.024
catechol containing compound metabolic processGO:000971220.024
reproductive processGO:0022414400.024
response to nicotineGO:003509420.024
developmental growthGO:00485891660.024
cellular response to steroid hormone stimulusGO:0071383310.024
response to bacteriumGO:0009617580.024
negative regulation of feeding behaviorGO:200025220.023
response to uvGO:000941130.023
tissue remodelingGO:004877140.023
regulation of transcription from rna polymerase ii promoterGO:00063571140.023
negative regulation of macromolecule metabolic processGO:0010605760.023
secondary metabolic processGO:001974830.023
protein localization to nucleusGO:003450430.022
protein targeting to nucleusGO:004474430.022
transportGO:00068102200.022
angiogenesisGO:00015251580.022
regulation of protein transportGO:005122330.022
multi organism processGO:00517041340.022
female gonad developmentGO:000858540.021
morphogenesis of an epitheliumGO:00020093330.021
protein importGO:001703830.021
regulation of cellular macromolecule biosynthetic processGO:20001122220.021
regulation of adenylate cyclase activityGO:004576160.021
positive regulation of rna metabolic processGO:0051254590.021
determination of left right symmetryGO:00073681790.021
negative regulation of sequestering of calcium ionGO:005128340.021
regulation of response to stimulusGO:00485832690.021
transcription dna templatedGO:00063511810.021
positive regulation of cytosolic calcium ion concentrationGO:000720440.020
muscle tissue developmentGO:00605371100.020
sequestering of calcium ionGO:005120830.020
nucleobase containing compound biosynthetic processGO:00346542050.020
purine ribonucleotide biosynthetic processGO:0009152200.020
negative regulation of protein transportGO:005122430.020
neuron projection morphogenesisGO:00488121610.020
endocrine processGO:005088620.020
cyclic purine nucleotide metabolic processGO:0052652180.020
regulation of nucleic acid templated transcriptionGO:19035062130.020
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.019
regulation of metabolic processGO:00192223590.019
cellular component biogenesisGO:00440851780.019
apoptotic process involved in developmentGO:190274220.019
tube morphogenesisGO:00352393490.019
response to external biotic stimulusGO:0043207970.019
fatty acid oxidationGO:001939510.019
anion transportGO:0006820380.019
regulation of wound healingGO:006104120.019
regulation of multicellular organismal processGO:00512392770.019
positive regulation of dna metabolic processGO:005105410.018
glial cell migrationGO:000834730.018
organelle assemblyGO:00709251100.018
regulation of rna biosynthetic processGO:20011412130.018
regulation of gene expressionGO:00104682650.018
negative regulation of biological processGO:00485193040.018
sequestering of metal ionGO:005123830.018
homeostasis of number of cellsGO:0048872620.018
hormone mediated signaling pathwayGO:000975590.018
hormone metabolic processGO:0042445190.018
segmentationGO:0035282970.018
cellular biosynthetic processGO:00442492860.017
protein import into nucleusGO:000660630.017
single organism organelle organizationGO:19025891990.017
defense responseGO:0006952470.017
cellular response to oxygen containing compoundGO:1901701200.017
cellular lipid metabolic processGO:0044255360.017
regulation of cellular component movementGO:0051270550.017
retinoic acid receptor signaling pathwayGO:0048384160.017
establishment of protein localization to organelleGO:007259440.017
response to woundingGO:00096111160.017
synaptic transmission cholinergicGO:000727140.017
establishment of localizationGO:00512342440.017
regulation of protein modification by small protein conjugation or removalGO:190332030.017
sensory perception of painGO:001923310.017
intracellular signal transductionGO:0035556850.017
response to light stimulusGO:0009416460.017
otolith morphogenesisGO:003247480.016
regulation of protein complex assemblyGO:004325430.016
regulation of signal transductionGO:00099662250.016
camera type eye developmentGO:00430102220.016
regulation of neurogenesisGO:0050767870.016
cellular component movementGO:00069283350.016
embryonic organ morphogenesisGO:00485622740.016
regulation of purine nucleotide biosynthetic processGO:1900371150.016
regulation of blood pressureGO:000821710.016
regulation of biological qualityGO:00650082630.016
neuron neuron synaptic transmissionGO:000727010.016
negative regulation of nitrogen compound metabolic processGO:0051172590.016
response to oxygen containing compoundGO:1901700550.016
response to organic cyclic compoundGO:0014070510.016
negative regulation of protein kinase activityGO:000646940.015
single organism nuclear importGO:190259330.015
response to ketoneGO:190165410.015
nucleocytoplasmic transportGO:000691340.015
digestive system developmentGO:00551232890.015
regulation of cellular protein metabolic processGO:0032268520.015
cellular response to lipidGO:0071396390.015
ribonucleotide biosynthetic processGO:0009260200.015
posterior lateral line developmentGO:0048916380.015
hepaticobiliary system developmentGO:0061008980.015
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.015
regulation of neuronal synaptic plasticityGO:004816810.015
pancreas developmentGO:0031016840.015
response to hormoneGO:0009725480.015
blood circulationGO:0008015870.015
inner ear developmentGO:00488391260.014
liver developmentGO:0001889960.014
carbohydrate biosynthetic processGO:001605110.014
diencephalon developmentGO:0021536580.014
positive regulation of secretionGO:005104710.014
positive regulation of leukocyte migrationGO:000268720.014
regulation of sequestering of calcium ionGO:005128240.014
cellular ketone metabolic processGO:0042180110.014
organic substance transportGO:0071702580.014
positive regulation of transportGO:005105020.014
negative regulation of developmental processGO:0051093650.014
regulation of cell motilityGO:2000145460.014
inositol phosphate metabolic processGO:004364710.014
positive regulation of blood circulationGO:190352420.013
cell morphogenesis involved in neuron differentiationGO:00486671630.013
adult behaviorGO:003053420.013
lymphocyte proliferationGO:004665110.013
neuron projection developmentGO:00311751800.013
tissue regenerationGO:0042246740.013
growth plate cartilage developmentGO:000341720.013
actomyosin structure organizationGO:0031032530.013
methylationGO:0032259220.013
glucose homeostasisGO:004259310.013
cellular component assemblyGO:00226071700.013
pectoral fin developmentGO:0033339500.013
head developmentGO:00603223030.013
neurological system processGO:0050877620.013
negative regulation of apoptotic processGO:0043066550.013
photoreceptor cell differentiationGO:0046530550.013
neuromast primordium migrationGO:0048883120.013
positive regulation of cellular catabolic processGO:003133130.013
positive regulation of camp metabolic processGO:003081620.013
polyol metabolic processGO:001975110.013
aromatic compound biosynthetic processGO:00194382170.013
ear developmentGO:00435831270.013
dna metabolic processGO:0006259270.012
cell motilityGO:00488702440.012
regulation of inflammatory responseGO:005072720.012
mitochondrion organizationGO:000700540.012
regulation of growthGO:0040008420.012
negative regulation of gene expressionGO:0010629650.012
protein heterooligomerizationGO:005129110.012
response to lipidGO:0033993600.012
b cell activationGO:004211320.012
mononuclear cell proliferationGO:003294310.012
regulation of biosynthetic processGO:00098892500.012
positive regulation of jak stat cascadeGO:004642720.012
positive regulation of biosynthetic processGO:0009891680.012
regulation of jak stat cascadeGO:004642530.012
reactive oxygen species biosynthetic processGO:190340910.012
cellular protein metabolic processGO:00442671290.012
cellular response to reactive oxygen speciesGO:003461420.012
regulation of dendrite morphogenesisGO:004881430.011
mitotic cell cycleGO:0000278640.011
response to amino acidGO:004320020.011
regionalizationGO:00030022740.011
amine metabolic processGO:000930820.011
regulation of transcription dna templatedGO:00063552130.011
regulation of neurological system processGO:003164420.011
cell deathGO:00082191210.011
regulation of circadian sleep wake cycleGO:004274910.011
behaviorGO:0007610740.011
regulation of peptidyl tyrosine phosphorylationGO:005073010.011
lipid homeostasisGO:005508830.011
cell activationGO:0001775160.011
cell morphogenesisGO:00009022890.011
pituitary gland developmentGO:0021983160.011
embryonic skeletal system developmentGO:0048706970.011
steroid hormone mediated signaling pathwayGO:004340190.011
heterocycle biosynthetic processGO:00181302150.011
response to inorganic substanceGO:0010035380.011
regulation of protein deacetylationGO:009031120.011
regulation of cellular amino acid metabolic processGO:000652100.011
cellular response to unfolded proteinGO:003462020.011
carbohydrate derivative biosynthetic processGO:1901137430.011
response to monosaccharideGO:003428430.011
fatty acid biosynthetic processGO:000663340.011
regulation of dna replicationGO:000627530.011
regulation of intracellular protein transportGO:003315730.011
cellular response to estrogen stimulusGO:0071391240.011
regulation of blood vessel sizeGO:005088020.011
regulation of cyclic nucleotide metabolic processGO:0030799150.011
lipid storageGO:001991510.011
negative regulation of signalingGO:0023057960.011
rna biosynthetic processGO:00327741810.011
mapk cascadeGO:0000165180.011
positive regulation of map kinase activityGO:004340630.010
hormone biosynthetic processGO:004244630.010
cellular amide metabolic processGO:004360340.010
organic acid transportGO:001584990.010
response to stressGO:00069502630.010
positive regulation of camp biosynthetic processGO:003081920.010
apoptotic process involved in morphogenesisGO:006056120.010
muscle structure developmentGO:00610611960.010
cell projection organizationGO:00300302840.010
nucleoside phosphate biosynthetic processGO:1901293210.010
negative regulation of cellular metabolic processGO:0031324770.010
fatty acid transportGO:001590810.010
wound healingGO:0042060900.010
regulation of camp metabolic processGO:003081490.010
positive regulation of cellular metabolic processGO:0031325940.010
positive regulation of gene expressionGO:0010628710.010
negative regulation of signal transductionGO:0009968940.010
regulation of peptidase activityGO:0052547230.010
circadian rhythmGO:0007623190.010
regulation of molecular functionGO:0065009700.010
neuron differentiationGO:00301823530.010
single organism biosynthetic processGO:0044711710.010
neuroblast proliferationGO:000740520.010

dio2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.014
thyroid gland diseaseDOID:5000.011
hypothyroidismDOID:145900.011
endocrine system diseaseDOID:2800.011
musculoskeletal system diseaseDOID:1700.011
muscle tissue diseaseDOID:6600.011
muscular diseaseDOID:008000000.011