IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

bmp8a

bone morphogenetic protein 8a

(Aliases: bmp8)

Entrez: 561963
Ensembl: ENSDARG00000035677
ZFIN: ZDB-GENE-030912-13
UniProtKB: Q1LWW7

Process Predictions
Disease Predictions

bmp8a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organic cyclic compound metabolic process	GO:1901360	301	0.405	Zebrafish
biosynthetic process	GO:0009058	294	0.377	Zebrafish
signal transduction	GO:0007165	455	0.320	Zebrafish Mouse
larval development	GO:0002164	2	0.255
heart development	GO:0007507	313	0.209	Zebrafish
phosphorus metabolic process	GO:0006793	109	0.207	Mouse
regulation of nitrogen compound metabolic process	GO:0051171	251	0.207	Zebrafish
maintenance of location	GO:0051235	4	0.176
heterocycle biosynthetic process	GO:0018130	215	0.154	Zebrafish
appendage morphogenesis	GO:0035107	56	0.146	Fly
ion transport	GO:0006811	114	0.140
locomotion	GO:0040011	313	0.138	Zebrafish
negative regulation of biological process	GO:0048519	304	0.138	Human Zebrafish Fly
cellular component morphogenesis	GO:0032989	336	0.137	Zebrafish
positive regulation of cell cycle	GO:0045787	3	0.136
regulation of signal transduction	GO:0009966	225	0.135	Zebrafish Mouse
negative regulation of cellular process	GO:0048523	283	0.133	Human Zebrafish
striated muscle cell differentiation	GO:0051146	129	0.132	Zebrafish
cellular amine metabolic process	GO:0044106	2	0.128
cellular macromolecule metabolic process	GO:0044260	391	0.128	Zebrafish Mouse
determination of bilateral symmetry	GO:0009855	204	0.126	Zebrafish
single organism biosynthetic process	GO:0044711	71	0.117
nucleic acid templated transcription	GO:0097659	181	0.117	Zebrafish
nitrogen compound metabolic process	GO:0006807	319	0.114	Zebrafish
multi organism process	GO:0051704	134	0.114	Zebrafish Mouse Fly
embryo development ending in birth or egg hatching	GO:0009792	271	0.113	Zebrafish
metal ion transport	GO:0030001	58	0.112
regulation of metal ion transport	GO:0010959	4	0.112
heterocycle metabolic process	GO:0046483	290	0.110	Zebrafish
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.109
apoptotic process	GO:0006915	116	0.108
ribonucleotide biosynthetic process	GO:0009260	20	0.107
phagocytosis	GO:0006909	3	0.106
cellular biosynthetic process	GO:0044249	286	0.105	Zebrafish
cellular aromatic compound metabolic process	GO:0006725	295	0.100	Zebrafish
cyclic purine nucleotide metabolic process	GO:0052652	18	0.098
modification dependent macromolecule catabolic process	GO:0043632	3	0.097
appendage development	GO:0048736	80	0.095	Fly
transcription dna templated	GO:0006351	181	0.093	Zebrafish
organic substance biosynthetic process	GO:1901576	289	0.091	Zebrafish
neuron differentiation	GO:0030182	353	0.091	Zebrafish
cyclic nucleotide biosynthetic process	GO:0009190	18	0.090
muscle cell differentiation	GO:0042692	139	0.084	Zebrafish
actin filament based process	GO:0030029	64	0.083
immune system development	GO:0002520	191	0.082
phosphate containing compound metabolic process	GO:0006796	108	0.081	Mouse
cytokinesis	GO:0000910	3	0.079
regulation of circadian rhythm	GO:0042752	4	0.079
regulation of primary metabolic process	GO:0080090	311	0.079	Zebrafish Mouse
regionalization	GO:0003002	274	0.078	Zebrafish Fly
single organism transport	GO:0044765	206	0.077	Human Fly
striated muscle cell development	GO:0055002	108	0.077	Zebrafish
inner ear development	GO:0048839	126	0.076
transport	GO:0006810	220	0.075	Human Fly
response to organic cyclic compound	GO:0014070	51	0.075
fin development	GO:0033333	77	0.075
nucleotide biosynthetic process	GO:0009165	21	0.075
sequestering of metal ion	GO:0051238	3	0.074
programmed cell death	GO:0012501	119	0.074
tissue remodeling	GO:0048771	4	0.073
cognition	GO:0050890	1	0.073
aromatic compound biosynthetic process	GO:0019438	217	0.072	Zebrafish
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.071
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.071	Zebrafish
aging	GO:0007568	2	0.070
response to external stimulus	GO:0009605	264	0.069	Human Zebrafish Mouse
regulation of sequestering of calcium ion	GO:0051282	4	0.069
cation transport	GO:0006812	81	0.068
regulation of multicellular organismal process	GO:0051239	277	0.068	Human Zebrafish Mouse Fly
regulation of cell communication	GO:0010646	232	0.068	Human Zebrafish Mouse Fly
embryonic heart tube development	GO:0035050	133	0.066	Zebrafish
single organism localization	GO:1902578	225	0.066	Human Fly
skeletal system development	GO:0001501	181	0.066	Zebrafish
regulation of systemic arterial blood pressure	GO:0003073	1	0.066
regulation of macromolecule metabolic process	GO:0060255	317	0.064	Zebrafish Mouse Fly
anterior posterior pattern specification	GO:0009952	152	0.062
regulation of anatomical structure morphogenesis	GO:0022603	130	0.062	Zebrafish
muscle structure development	GO:0061061	196	0.061	Zebrafish Fly
response to nitrogen compound	GO:1901698	19	0.061
organonitrogen compound metabolic process	GO:1901564	74	0.061
regulation of cellular amine metabolic process	GO:0033238	0	0.061
ribose phosphate biosynthetic process	GO:0046390	20	0.060
response to stress	GO:0006950	263	0.059
establishment of localization	GO:0051234	244	0.058	Human Fly
homeostatic process	GO:0042592	142	0.057	Human Zebrafish Mouse
system process	GO:0003008	185	0.057
protein modification process	GO:0036211	100	0.057	Mouse
amine metabolic process	GO:0009308	2	0.056
regulation of ion transmembrane transporter activity	GO:0032412	2	0.056
ubiquitin dependent protein catabolic process	GO:0006511	3	0.056
death	GO:0016265	121	0.056
sensory organ development	GO:0007423	393	0.055	Zebrafish
embryonic organ development	GO:0048568	381	0.055	Zebrafish
positive regulation of transport	GO:0051050	2	0.054
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.054	Zebrafish
positive regulation of cellular component biogenesis	GO:0044089	3	0.053	Fly
single organism organelle organization	GO:1902589	199	0.053
proteasomal protein catabolic process	GO:0010498	2	0.052
organic cyclic compound biosynthetic process	GO:1901362	223	0.052	Zebrafish
response to external biotic stimulus	GO:0043207	97	0.051
response to wounding	GO:0009611	116	0.051
meiotic nuclear division	GO:0007126	4	0.051
regulation of signaling	GO:0023051	235	0.050	Human Zebrafish Mouse Fly
nucleobase containing compound biosynthetic process	GO:0034654	205	0.050	Zebrafish
hematopoietic or lymphoid organ development	GO:0048534	191	0.050
response to endogenous stimulus	GO:0009719	83	0.050
macromolecule biosynthetic process	GO:0009059	227	0.049	Zebrafish
regulation of biological quality	GO:0065008	263	0.049	Human Zebrafish Mouse Fly
rna biosynthetic process	GO:0032774	181	0.049	Zebrafish
response to organic substance	GO:0010033	153	0.049
regulation of ion transmembrane transport	GO:0034765	18	0.049
muscle cell development	GO:0055001	115	0.049	Zebrafish
modification dependent protein catabolic process	GO:0019941	3	0.048
neuron development	GO:0048666	262	0.048	Zebrafish
transcription from rna polymerase ii promoter	GO:0006366	80	0.048	Zebrafish
reproductive process	GO:0022414	40	0.048	Zebrafish Mouse Fly
negative regulation of sequestering of calcium ion	GO:0051283	4	0.048
response to biotic stimulus	GO:0009607	97	0.048
hemopoiesis	GO:0030097	183	0.046
small molecule metabolic process	GO:0044281	77	0.046
neurological system process	GO:0050877	62	0.046
regulation of protein complex assembly	GO:0043254	3	0.045
ear development	GO:0043583	127	0.045
central nervous system development	GO:0007417	387	0.045
response to other organism	GO:0051707	97	0.044
organonitrogen compound biosynthetic process	GO:1901566	47	0.044
purine containing compound biosynthetic process	GO:0072522	20	0.043
regulation of dendrite morphogenesis	GO:0048814	3	0.043
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.043	Zebrafish
sleep	GO:0030431	1	0.043
meiotic cell cycle process	GO:1903046	3	0.043
cell morphogenesis	GO:0000902	289	0.042	Zebrafish
somite development	GO:0061053	96	0.042
purine nucleotide biosynthetic process	GO:0006164	20	0.042
positive regulation of cell communication	GO:0010647	56	0.041	Zebrafish Mouse
regulation of cellular metabolic process	GO:0031323	320	0.040	Zebrafish Mouse
positive regulation of cell division	GO:0051781	2	0.039
sequestering of calcium ion	GO:0051208	3	0.039
cellular response to chemical stimulus	GO:0070887	157	0.039
cellular response to external stimulus	GO:0071496	2	0.039
ion homeostasis	GO:0050801	41	0.038
lipid storage	GO:0019915	1	0.038
regeneration	GO:0031099	91	0.038
regulation of establishment of protein localization	GO:0070201	4	0.038
negative regulation of cell death	GO:0060548	60	0.037
nephron tubule morphogenesis	GO:0072078	1	0.036
protein polymerization	GO:0051258	4	0.036
organelle organization	GO:0006996	227	0.036
purine ribonucleotide biosynthetic process	GO:0009152	20	0.036
protein metabolic process	GO:0019538	183	0.036	Mouse
release of sequestered calcium ion into cytosol	GO:0051209	3	0.036
renal tubule morphogenesis	GO:0061333	1	0.036
peptidyl serine modification	GO:0018209	2	0.036
entrainment of circadian clock	GO:0009649	2	0.036
regulation of transmembrane transport	GO:0034762	18	0.035
cell part morphogenesis	GO:0032990	246	0.035	Zebrafish
defense response to other organism	GO:0098542	33	0.035
g protein coupled receptor signaling pathway	GO:0007186	74	0.035
cellular protein catabolic process	GO:0044257	4	0.035
cellular macromolecule biosynthetic process	GO:0034645	224	0.035	Zebrafish
gland development	GO:0048732	143	0.035
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.035	Zebrafish Mouse
striated muscle tissue development	GO:0014706	110	0.034	Zebrafish
positive regulation of signal transduction	GO:0009967	56	0.034	Zebrafish Mouse
cellular response to xenobiotic stimulus	GO:0071466	35	0.034
determination of heart left right asymmetry	GO:0061371	117	0.034	Zebrafish
carboxylic acid metabolic process	GO:0019752	22	0.034
regulation of response to stimulus	GO:0048583	269	0.034	Zebrafish Mouse
dorsal ventral pattern formation	GO:0009953	125	0.034	Zebrafish Fly
intracellular signal transduction	GO:0035556	85	0.034	Mouse
regulation of transcription dna templated	GO:0006355	213	0.033	Zebrafish
regulation of circadian sleep wake cycle	GO:0042749	1	0.033
cell projection organization	GO:0030030	284	0.033	Zebrafish
cell death	GO:0008219	121	0.033
nucleobase containing compound metabolic process	GO:0006139	274	0.033	Zebrafish
chordate embryonic development	GO:0043009	271	0.033	Zebrafish
muscle tissue development	GO:0060537	110	0.032	Zebrafish
cell surface receptor signaling pathway	GO:0007166	325	0.032	Zebrafish Mouse
morphogenesis of an epithelium	GO:0002009	333	0.032	Zebrafish
regulation of protein transport	GO:0051223	3	0.032
regulation of rna biosynthetic process	GO:2001141	213	0.032	Zebrafish
exocytosis	GO:0006887	1	0.032
skeletal muscle tissue development	GO:0007519	67	0.031	Zebrafish
hatching	GO:0035188	4	0.031
heart morphogenesis	GO:0003007	156	0.031	Zebrafish
positive regulation of macromolecule metabolic process	GO:0010604	93	0.030	Mouse
specification of symmetry	GO:0009799	204	0.030	Zebrafish
rna metabolic process	GO:0016070	219	0.030	Zebrafish
cellular ketone metabolic process	GO:0042180	11	0.029
regulation of biosynthetic process	GO:0009889	250	0.029	Zebrafish
positive regulation of rna biosynthetic process	GO:1902680	57	0.029
spemann organizer formation at the embryonic shield	GO:0060063	2	0.029	Zebrafish
regulation of transporter activity	GO:0032409	2	0.029
positive regulation of signaling	GO:0023056	56	0.029	Zebrafish Mouse
cellular response to endogenous stimulus	GO:0071495	68	0.029
kupffer s vesicle development	GO:0070121	50	0.029
determination of ventral identity	GO:0048264	21	0.029	Zebrafish
regulation of transmembrane transporter activity	GO:0022898	2	0.029
light absorption	GO:0016037	2	0.028
phagocytosis engulfment	GO:0006911	1	0.028
response to nutrient	GO:0007584	3	0.028
medial fin development	GO:0033338	16	0.028
cellular nitrogen compound metabolic process	GO:0034641	290	0.028	Zebrafish
microtubule based process	GO:0007017	60	0.028
cytoskeleton organization	GO:0007010	96	0.028
fin morphogenesis	GO:0033334	53	0.028
positive regulation of biological process	GO:0048518	253	0.028	Human Zebrafish Mouse Fly
negative regulation of gene expression	GO:0010629	65	0.028	Fly
somitogenesis	GO:0001756	87	0.028
tissue regeneration	GO:0042246	74	0.027
membrane invagination	GO:0010324	1	0.027
nucleoside phosphate biosynthetic process	GO:1901293	21	0.027
nephron epithelium morphogenesis	GO:0072088	1	0.027
multicellular organism growth	GO:0035264	4	0.027
mitotic cell cycle process	GO:1903047	48	0.026
determination of left right symmetry	GO:0007368	179	0.026	Zebrafish
single organism metabolic process	GO:0044710	217	0.026	Human Mouse
formation of primary germ layer	GO:0001704	62	0.026	Zebrafish
nephron morphogenesis	GO:0072028	2	0.026
immune system process	GO:0002376	241	0.026
organelle assembly	GO:0070925	110	0.026
regulation of dendrite development	GO:0050773	3	0.026
determination of dorsal ventral asymmetry	GO:0048262	34	0.026	Zebrafish
regulation of binding	GO:0051098	3	0.026
head development	GO:0060322	303	0.026
negative regulation of secretion	GO:0051048	2	0.026	Human
regulation of ion transport	GO:0043269	22	0.025
camera type eye development	GO:0043010	222	0.025	Zebrafish
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.025
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.025
oocyte maturation	GO:0001556	4	0.025	Zebrafish
establishment of localization in cell	GO:0051649	77	0.025	Human Fly
lipid metabolic process	GO:0006629	52	0.025
regulation of metabolic process	GO:0019222	359	0.025	Human Zebrafish Mouse Fly
camera type eye morphogenesis	GO:0048593	108	0.025	Zebrafish
transmembrane transport	GO:0055085	120	0.024
regulation of localization	GO:0032879	104	0.024	Human Fly
positive regulation of cellular catabolic process	GO:0031331	3	0.024
regulation of blood pressure	GO:0008217	1	0.024
eye development	GO:0001654	277	0.024	Zebrafish
regulation of skeletal muscle tissue development	GO:0048641	4	0.024
odontogenesis of dentin containing tooth	GO:0042475	1	0.024
regulation of neurotransmitter secretion	GO:0046928	1	0.023	Fly
regulation of homeostatic process	GO:0032844	9	0.023	Human Mouse
cellular component biogenesis	GO:0044085	178	0.023	Zebrafish Fly
liver development	GO:0001889	96	0.023
response to corticosteroid	GO:0031960	1	0.023
organic acid metabolic process	GO:0006082	31	0.022
negative regulation of nuclear division	GO:0051784	3	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.022
circadian sleep wake cycle	GO:0042745	2	0.022
regulation of cellular ketone metabolic process	GO:0010565	7	0.022
response to vitamin	GO:0033273	3	0.022
negative regulation of macromolecule metabolic process	GO:0010605	76	0.022	Fly
regulation of microtubule cytoskeleton organization	GO:0070507	3	0.022
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.022	Zebrafish
regulation of organelle organization	GO:0033043	29	0.022
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.022
positive regulation of map kinase activity	GO:0043406	3	0.022
stem cell proliferation	GO:0072089	4	0.021
positive regulation of muscle organ development	GO:0048636	1	0.021	Fly
meiotic chromosome segregation	GO:0045132	3	0.021
peptidyl serine phosphorylation	GO:0018105	1	0.021
connective tissue development	GO:0061448	99	0.021
cranial nerve development	GO:0021545	42	0.021
generation of neurons	GO:0048699	385	0.021	Zebrafish
cellular amino acid metabolic process	GO:0006520	7	0.021
myotube differentiation	GO:0014902	45	0.021	Zebrafish
renal system process involved in regulation of systemic arterial blood pressure	GO:0003071	1	0.021
myofibril assembly	GO:0030239	48	0.021
response to steroid hormone	GO:0048545	35	0.021
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.021	Zebrafish Mouse
embryonic skeletal joint development	GO:0072498	3	0.021
oxidation reduction process	GO:0055114	41	0.021
response to abiotic stimulus	GO:0009628	122	0.021
adult behavior	GO:0030534	2	0.021
response to monosaccharide	GO:0034284	3	0.021
growth	GO:0040007	174	0.021	Fly
behavior	GO:0007610	74	0.021
leukocyte proliferation	GO:0070661	1	0.020
positive regulation of cellular process	GO:0048522	201	0.020	Zebrafish Mouse Fly
membrane repolarization	GO:0086009	2	0.020
positive regulation of catabolic process	GO:0009896	4	0.020
regulation of cellular protein catabolic process	GO:1903362	1	0.020
hormone biosynthetic process	GO:0042446	3	0.020
cell cycle process	GO:0022402	53	0.020
regulation of inflammatory response	GO:0050727	2	0.020
transmission of nerve impulse	GO:0019226	19	0.020
b cell activation	GO:0042113	2	0.020
embryonic organ morphogenesis	GO:0048562	274	0.020	Zebrafish
pathway restricted smad protein phosphorylation	GO:0060389	1	0.020	Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.020
embryonic heart tube morphogenesis	GO:0003143	108	0.020	Zebrafish
spermatid development	GO:0007286	2	0.020
inner ear receptor cell differentiation	GO:0060113	29	0.020
positive regulation of protein complex assembly	GO:0031334	2	0.019
smooth muscle contraction	GO:0006939	2	0.019
cell aging	GO:0007569	2	0.019
embryonic skeletal joint morphogenesis	GO:0060272	3	0.019
regulation of cell development	GO:0060284	100	0.019	Zebrafish
carbohydrate derivative biosynthetic process	GO:1901137	43	0.019
circadian sleep wake cycle sleep	GO:0050802	1	0.019
regulation of programmed cell death	GO:0043067	101	0.019
positive regulation of cell activation	GO:0050867	1	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.019
positive regulation of gene expression	GO:0010628	71	0.019
defense response to bacterium	GO:0042742	22	0.019
circadian sleep wake cycle process	GO:0022410	2	0.019
developmental growth	GO:0048589	166	0.019	Fly
cellular response to organic substance	GO:0071310	105	0.019
eye morphogenesis	GO:0048592	144	0.018	Zebrafish
brain development	GO:0007420	293	0.018
regulation of cell cycle process	GO:0010564	20	0.018
positive regulation of lymphocyte mediated immunity	GO:0002708	1	0.018
protein phosphorylation	GO:0006468	47	0.018	Mouse
oxoacid metabolic process	GO:0043436	31	0.018
regulation of multicellular organism growth	GO:0040014	4	0.018
sensory organ morphogenesis	GO:0090596	200	0.018	Zebrafish
response to drug	GO:0042493	3	0.018
embryonic limb morphogenesis	GO:0030326	2	0.018
hepaticobiliary system development	GO:0061008	98	0.018
nucleic acid metabolic process	GO:0090304	244	0.018	Zebrafish
response to topologically incorrect protein	GO:0035966	2	0.018
cellular response to stress	GO:0033554	62	0.018
regulation of cytoplasmic transport	GO:1903649	4	0.017
medial fin morphogenesis	GO:0035141	14	0.017
gene expression	GO:0010467	252	0.017	Zebrafish Fly
tissue homeostasis	GO:0001894	25	0.017	Zebrafish
female meiotic division	GO:0007143	2	0.017
embryonic hemopoiesis	GO:0035162	53	0.017
microtubule cytoskeleton organization	GO:0000226	33	0.017
embryonic skeletal system morphogenesis	GO:0048704	93	0.017	Zebrafish
nucleotide metabolic process	GO:0009117	28	0.017
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.017	Zebrafish Mouse
regulation of cyclic nucleotide metabolic process	GO:0030799	15	0.017
cellular localization	GO:0051641	97	0.017	Human Fly
regulation of apoptotic process	GO:0042981	98	0.017
lipid catabolic process	GO:0016042	4	0.017
negative regulation of cell communication	GO:0010648	96	0.017	Human
cell proliferation	GO:0008283	80	0.017	Zebrafish
regulation of phosphate metabolic process	GO:0019220	43	0.017	Mouse
actin polymerization or depolymerization	GO:0008154	2	0.017
negative regulation of programmed cell death	GO:0043069	58	0.017
protein secretion	GO:0009306	1	0.016
cellular lipid catabolic process	GO:0044242	3	0.016
regulation of cell cycle	GO:0051726	52	0.016
regulation of cell activation	GO:0050865	1	0.016
heart looping	GO:0001947	94	0.016	Zebrafish
multicellular organism reproduction	GO:0032504	35	0.016	Zebrafish Mouse Fly
regulation of cellular amino acid metabolic process	GO:0006521	0	0.016
fin regeneration	GO:0031101	51	0.016
regulation of organ growth	GO:0046620	3	0.016
negative regulation of mitosis	GO:0045839	3	0.016
nucleocytoplasmic transport	GO:0006913	4	0.016
positive regulation of metabolic process	GO:0009893	108	0.016	Human Mouse
cellular response to unfolded protein	GO:0034620	2	0.016
skeletal system morphogenesis	GO:0048705	102	0.016	Zebrafish
regulation of cell death	GO:0010941	103	0.016
response to chemical	GO:0042221	320	0.016	Zebrafish
cell projection morphogenesis	GO:0048858	244	0.016	Zebrafish
neuron projection morphogenesis	GO:0048812	161	0.016	Zebrafish
regulation of protein catabolic process	GO:0042176	1	0.016
regulation of myotube differentiation	GO:0010830	2	0.016
positive regulation of myeloid cell differentiation	GO:0045639	2	0.016
regulation of receptor activity	GO:0010469	2	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.015
cyclic nucleotide metabolic process	GO:0009187	18	0.015
cartilage development	GO:0051216	96	0.015
inner ear receptor cell fate commitment	GO:0060120	4	0.015
cell morphogenesis involved in differentiation	GO:0000904	195	0.015	Zebrafish
response to nutrient levels	GO:0031667	10	0.015	Human Mouse
negative regulation of secretion by cell	GO:1903531	2	0.015	Human
i kappab kinase nf kappab signaling	GO:0007249	4	0.015
epithelial tube morphogenesis	GO:0060562	148	0.015	Zebrafish
protein localization to nucleus	GO:0034504	3	0.015
ossification	GO:0001503	23	0.015	Mouse
digestive tract development	GO:0048565	265	0.015	Zebrafish
sensory perception of pain	GO:0019233	1	0.015
carbohydrate derivative metabolic process	GO:1901135	61	0.015
calcium ion transport into cytosol	GO:0060402	3	0.015
neuromuscular synaptic transmission	GO:0007274	2	0.015	Fly
immune response	GO:0006955	28	0.015
regulation of cellular biosynthetic process	GO:0031326	245	0.014	Zebrafish
negative regulation of metabolic process	GO:0009892	86	0.014	Fly
regulation of blood vessel size	GO:0050880	2	0.014
cellular protein metabolic process	GO:0044267	129	0.014	Mouse
macromolecule modification	GO:0043412	111	0.014	Mouse
regulation of phosphorus metabolic process	GO:0051174	43	0.014	Mouse
multicellular organismal signaling	GO:0035637	22	0.014
regulation of jak stat cascade	GO:0046425	3	0.014
ovulation cycle	GO:0042698	2	0.014
cardiocyte differentiation	GO:0035051	44	0.014
peptide transport	GO:0015833	1	0.014	Human
embryonic appendage morphogenesis	GO:0035113	30	0.014
stem cell maintenance	GO:0019827	4	0.014
regulation of cell differentiation	GO:0045595	142	0.014	Zebrafish
response to starvation	GO:0042594	5	0.014
photoreceptor cell differentiation	GO:0046530	55	0.014	Zebrafish
hormone transport	GO:0009914	2	0.014	Human
regulation of hormone levels	GO:0010817	21	0.014	Human
cellular response to nutrient levels	GO:0031669	2	0.014
specification of organ identity	GO:0010092	2	0.014
response to hormone	GO:0009725	48	0.014
cellular hormone metabolic process	GO:0034754	19	0.014
signal transduction in absence of ligand	GO:0038034	1	0.014
positive regulation of secretion	GO:0051047	1	0.014
regulation of molecular function	GO:0065009	70	0.014
pharyngeal muscle development	GO:0043282	4	0.014
lymphocyte proliferation	GO:0046651	1	0.013
positive regulation of molecular function	GO:0044093	33	0.013
vasculature development	GO:0001944	278	0.013	Zebrafish
cellular component assembly	GO:0022607	170	0.013	Zebrafish Fly
muscle fiber development	GO:0048747	52	0.013	Zebrafish
negative regulation of feeding behavior	GO:2000252	2	0.013
negative regulation of hormone secretion	GO:0046888	2	0.013	Human
regulation of nucleocytoplasmic transport	GO:0046822	2	0.013
response to carbohydrate	GO:0009743	3	0.013
cellular protein modification process	GO:0006464	100	0.013	Mouse
negative regulation of defense response	GO:0031348	2	0.013
cell aggregation	GO:0098743	3	0.013
renal system development	GO:0072001	94	0.013
skeletal muscle fiber development	GO:0048741	35	0.013	Zebrafish
cytosolic calcium ion transport	GO:0060401	3	0.013
nucleobase containing small molecule metabolic process	GO:0055086	32	0.013
purine ribonucleotide metabolic process	GO:0009150	27	0.013
establishment of organelle localization	GO:0051656	45	0.013
positive regulation of nucleotide catabolic process	GO:0030813	1	0.013
regulation of nucleotide biosynthetic process	GO:0030808	15	0.012
calcium ion transport	GO:0006816	18	0.012
response to ketone	GO:1901654	1	0.012
positive regulation of cellular metabolic process	GO:0031325	94	0.012	Mouse
microtubule polymerization or depolymerization	GO:0031109	3	0.012
negative regulation of signal transduction	GO:0009968	94	0.012
neurotransmitter transport	GO:0006836	2	0.012	Fly
cellular response to growth factor stimulus	GO:0071363	39	0.012
pectoral fin development	GO:0033339	50	0.012
metal ion homeostasis	GO:0055065	26	0.012
regulation of bone remodeling	GO:0046850	2	0.012
regulation of stem cell differentiation	GO:2000736	4	0.012
cellular component movement	GO:0006928	335	0.012	Zebrafish
cellular cation homeostasis	GO:0030003	17	0.012
cellular response to reactive oxygen species	GO:0034614	2	0.012
sensory perception	GO:0007600	39	0.012
regulation of cell shape	GO:0008360	1	0.012
actin cytoskeleton organization	GO:0030036	63	0.012
regulation of nucleic acid templated transcription	GO:1903506	213	0.012	Zebrafish
negative regulation of catabolic process	GO:0009895	3	0.012
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	1	0.012
aorta development	GO:0035904	4	0.012
cellular calcium ion homeostasis	GO:0006874	13	0.012
cytoskeleton dependent cytokinesis	GO:0061640	3	0.012
entrainment of circadian clock by photoperiod	GO:0043153	1	0.012
nuclear transport	GO:0051169	4	0.012
wound healing	GO:0042060	90	0.012
response to lipid	GO:0033993	60	0.012
heart contraction	GO:0060047	71	0.012
cellular response to molecule of bacterial origin	GO:0071219	3	0.012
gastrulation	GO:0007369	208	0.012	Zebrafish
regulation of protein polymerization	GO:0032271	2	0.012
macromolecular complex assembly	GO:0065003	35	0.012	Zebrafish
regulation of cytokine production	GO:0001817	3	0.012
cellular response to extracellular stimulus	GO:0031668	2	0.012
positive regulation of cytoskeleton organization	GO:0051495	3	0.012
positive regulation of chromatin modification	GO:1903310	1	0.012
defense response to fungus	GO:0050832	2	0.011
ovulation cycle process	GO:0022602	2	0.011
negative regulation of cellular catabolic process	GO:0031330	3	0.011
monovalent inorganic cation transport	GO:0015672	42	0.011
axon development	GO:0061564	166	0.011	Zebrafish
protein stabilization	GO:0050821	2	0.011
auditory receptor cell fate commitment	GO:0009912	4	0.011
cardiac atrium development	GO:0003230	4	0.011
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.011
cell migration	GO:0016477	237	0.011
organophosphate biosynthetic process	GO:0090407	23	0.011
regulation of protein phosphorylation	GO:0001932	18	0.011	Mouse
regulation of cyclic nucleotide biosynthetic process	GO:0030802	15	0.011
calcium ion import	GO:0070509	4	0.011
mononuclear cell proliferation	GO:0032943	1	0.011
fertilization	GO:0009566	3	0.011
cation transmembrane transport	GO:0098655	65	0.011
gamete generation	GO:0007276	33	0.011	Zebrafish Mouse Fly
bmp signaling pathway	GO:0030509	52	0.011	Zebrafish
segmentation	GO:0035282	97	0.011
response to alkaloid	GO:0043279	2	0.011
neuroblast proliferation	GO:0007405	2	0.011
regulation of circadian sleep wake cycle sleep	GO:0045187	1	0.011
calcium ion homeostasis	GO:0055074	19	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
cell cycle	GO:0007049	93	0.011
spermatid differentiation	GO:0048515	2	0.011

bmp8a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.046
disease of metabolism	DOID:0014667	0.024
musculoskeletal system disease	DOID:17	0.019
inherited metabolic disorder	DOID:655	0.011

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