Danio rerio

0 known processes

si:dkey-177e13.4

si:dkey-177e13.4

(Aliases: wu:fk66d05,fk66d05)

si:dkey-177e13.4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.090
cellular macromolecule metabolic processGO:00442603910.089
agingGO:000756820.085
signal transductionGO:00071654550.083
brain developmentGO:00074202930.082
cellular macromolecule biosynthetic processGO:00346452240.071
rna metabolic processGO:00160702190.071
regulation of cellular metabolic processGO:00313233200.070
head developmentGO:00603223030.069
immune system processGO:00023762410.067
cellular aromatic compound metabolic processGO:00067252950.067
lipid storageGO:001991510.066
regulation of metabolic processGO:00192223590.064
regulation of macromolecule metabolic processGO:00602553170.063
transcription dna templatedGO:00063511810.059
cellular nitrogen compound metabolic processGO:00346412900.059
central nervous system developmentGO:00074173870.058
negative regulation of biological processGO:00485193040.058
nucleic acid metabolic processGO:00903042440.057
nitrogen compound metabolic processGO:00068073190.057
organic cyclic compound metabolic processGO:19013603010.057
regulation of cellular macromolecule biosynthetic processGO:20001122220.055
nuclear transportGO:005116940.055
regulation of cellular biosynthetic processGO:00313262450.055
heterocycle metabolic processGO:00464832900.055
regulation of primary metabolic processGO:00800903110.054
chordate embryonic developmentGO:00430092710.053
positive regulation of transportGO:005105020.053
regulation of epithelial cell proliferationGO:005067830.052
nucleocytoplasmic transportGO:000691340.051
endocrine processGO:005088620.050
negative regulation of cellular processGO:00485232830.050
peptidyl serine phosphorylationGO:001810510.050
regulation of establishment of protein localizationGO:007020140.049
embryonic organ developmentGO:00485683810.049
rna biosynthetic processGO:00327741810.048
regulation of transcription dna templatedGO:00063552130.047
nucleobase containing compound metabolic processGO:00061392740.047
regulation of biosynthetic processGO:00098892500.046
regulation of response to stimulusGO:00485832690.046
organic substance biosynthetic processGO:19015762890.046
digestive system developmentGO:00551232890.046
heterocycle biosynthetic processGO:00181302150.046
maintenance of locationGO:005123540.046
biosynthetic processGO:00090582940.046
multicellular organism growthGO:003526440.044
macromolecule biosynthetic processGO:00090592270.044
eye developmentGO:00016542770.044
regulation of nucleobase containing compound metabolic processGO:00192192500.044
regulation of nitrogen compound metabolic processGO:00511712510.044
establishment of protein localization to organelleGO:007259440.043
regulation of gene expressionGO:00104682650.043
amine metabolic processGO:000930820.043
regulation of macromolecule biosynthetic processGO:00105562250.043
regulation of cytokine productionGO:000181730.042
regulation of metal ion transportGO:001095940.041
aromatic compound biosynthetic processGO:00194382170.041
regulation of protein transportGO:005122330.040
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.040
regulation of multicellular organism growthGO:004001440.039
nucleobase containing compound biosynthetic processGO:00346542050.039
cellular response to external stimulusGO:007149620.039
single organism localizationGO:19025782250.039
organic cyclic compound biosynthetic processGO:19013622230.039
response to stressGO:00069502630.038
tube morphogenesisGO:00352393490.038
cellular nitrogen compound biosynthetic processGO:00442712180.037
meiotic nuclear divisionGO:000712640.037
microtubule organizing center organizationGO:003102310.037
establishment of localizationGO:00512342440.037
immune system developmentGO:00025201910.037
protein localization to nucleusGO:003450430.037
protein targeting to nucleusGO:004474430.037
nucleic acid templated transcriptionGO:00976591810.037
negative regulation of protein phosphorylationGO:000193340.037
meiotic cell cycle processGO:190304630.036
cellular amine metabolic processGO:004410620.036
positive regulation of cellular component biogenesisGO:004408930.036
regulation of rna metabolic processGO:00512522240.036
response to chemicalGO:00422213200.036
regulation of developmental processGO:00507932470.035
regulation of multicellular organismal developmentGO:20000262230.035
regulation of signal transductionGO:00099662250.035
protein import into nucleusGO:000660630.035
nuclear importGO:005117030.035
single organism nuclear importGO:190259330.035
single organism metabolic processGO:00447102170.035
positive regulation of cellular processGO:00485222010.035
sensory organ developmentGO:00074233930.035
response to monosaccharideGO:003428430.035
single organism transportGO:00447652060.034
response to alkaloidGO:004327920.034
regulation of endocrine processGO:004406020.034
synaptic growth at neuromuscular junctionGO:005112420.034
gene expressionGO:00104672520.034
cell surface receptor signaling pathwayGO:00071663250.033
regulation of reactive oxygen species metabolic processGO:200037720.033
hormone transportGO:000991420.033
regulation of rna biosynthetic processGO:20011412130.033
regulation of intracellular protein transportGO:003315730.033
regulation of blood pressureGO:000821710.033
regulation of cell communicationGO:00106462320.033
cognitionGO:005089010.033
regulation of cellular amino acid metabolic processGO:000652100.032
macromolecule modificationGO:00434121110.032
regulation of multicellular organismal processGO:00512392770.032
regulation of cellular amine metabolic processGO:003323800.032
positive regulation of protein complex assemblyGO:003133420.032
zymogen activationGO:003163830.032
regulation of peptidyl tyrosine phosphorylationGO:005073010.032
urogenital system developmentGO:0001655970.032
protein metabolic processGO:00195381830.032
regulation of stem cell differentiationGO:200073640.031
regulation of nucleic acid templated transcriptionGO:19035062130.031
response to other organismGO:0051707970.031
regulation of bindingGO:005109830.031
regulation of protein localization to nucleusGO:190018020.031
purine ribonucleoside monophosphate catabolic processGO:000916940.031
peptidyl serine modificationGO:001820920.031
cellular biosynthetic processGO:00442492860.031
hemopoiesisGO:00300971830.031
locomotor rhythmGO:004547530.031
transportGO:00068102200.031
generation of neuronsGO:00486993850.031
regulation of protein complex assemblyGO:004325430.031
centrosome organizationGO:005129710.031
heart developmentGO:00075073130.030
cellular carbohydrate metabolic processGO:004426240.030
positive regulation of cellular catabolic processGO:003133130.030
negative regulation of signalingGO:0023057960.030
cell migrationGO:00164772370.030
regulation of synaptic plasticityGO:004816710.030
regulation of reproductive processGO:200024140.030
regulation of cytoplasmic transportGO:190364940.030
regulation of protein import into nucleusGO:004230620.030
purine nucleoside monophosphate catabolic processGO:000912840.029
positive regulation of catabolic processGO:000989640.029
positive regulation of biological processGO:00485182530.029
vasculature developmentGO:00019442780.029
regulation of nucleocytoplasmic transportGO:004682220.029
regulation of synapse organizationGO:005080730.029
cellular ketone metabolic processGO:0042180110.029
ubiquitin dependent protein catabolic processGO:000651130.029
positive regulation of secretion by cellGO:190353210.029
regulation of hormone secretionGO:004688320.029
regulation of wound healingGO:006104120.029
positive regulation of muscle cell differentiationGO:005114910.029
positive regulation of nitrogen compound metabolic processGO:0051173690.029
regulation of systemic arterial blood pressureGO:000307310.029
regulation of signalingGO:00230512350.028
positive regulation of epithelial cell migrationGO:001063420.028
extrinsic apoptotic signaling pathwayGO:009719130.028
cell deathGO:00082191210.028
leukocyte proliferationGO:007066110.028
cell substrate adhesionGO:003158940.028
homeostatic processGO:00425921420.028
positive regulation of secretionGO:005104710.028
single organism organelle organizationGO:19025891990.028
regulation of i kappab kinase nf kappab signalingGO:004312240.028
mitochondrion organizationGO:000700540.027
digestive tract developmentGO:00485652650.027
ribonucleoside monophosphate catabolic processGO:000915840.027
positive regulation of nucleobase containing compound metabolic processGO:0045935690.027
regulation of protein targetingGO:190353320.027
neuron differentiationGO:00301823530.027
negative regulation of protein transportGO:005122430.027
phagocytosisGO:000690930.027
stem cell maintenanceGO:001982740.027
response to uvGO:000941130.027
protein importGO:001703830.027
protein polymerizationGO:005125840.027
cellular component disassemblyGO:002241110.027
cellular response to extracellular stimulusGO:003166820.026
positive regulation of cytokine productionGO:000181920.026
cellular component morphogenesisGO:00329893360.026
hormone secretionGO:004687920.026
regulation of cell activationGO:005086510.026
regulation of dendrite morphogenesisGO:004881430.026
embryo development ending in birth or egg hatchingGO:00097922710.026
nucleoside monophosphate catabolic processGO:000912540.026
kidney developmentGO:0001822920.026
gtp metabolic processGO:004603940.025
negative regulation of cytoplasmic transportGO:190365020.025
regulation of sodium ion transportGO:000202820.025
protein dephosphorylationGO:000647030.025
atp catabolic processGO:000620040.025
regulation of cellular ketone metabolic processGO:001056570.025
transmembrane transportGO:00550851200.025
renal system developmentGO:0072001940.025
response to corticosteroidGO:003196010.025
blood vessel morphogenesisGO:00485142160.025
skeletal system developmentGO:00015011810.025
response to organic substanceGO:00100331530.025
negative regulation of protein kinase activityGO:000646940.025
organelle organizationGO:00069962270.025
renal system process involved in regulation of systemic arterial blood pressureGO:000307110.025
regulation of extrinsic apoptotic signaling pathwayGO:200123630.025
gtp catabolic processGO:000618420.024
regulation of jak stat cascadeGO:004642530.024
regulation of dendrite developmentGO:005077330.024
positive regulation of cell cycleGO:004578730.024
negative regulation of protein localization to nucleusGO:190018120.024
cellular amino acid metabolic processGO:000652070.024
response to hexoseGO:000974630.024
oocyte maturationGO:000155640.024
positive regulation of myeloid cell differentiationGO:004563920.024
response to biotic stimulusGO:0009607970.024
regulation of circadian rhythmGO:004275240.024
embryonic organ morphogenesisGO:00485622740.024
gas transportGO:001566930.024
system processGO:00030081850.024
apoptotic processGO:00069151160.024
response to external biotic stimulusGO:0043207970.023
regulation of protein catabolic processGO:004217610.023
modification dependent macromolecule catabolic processGO:004363230.023
meiotic chromosome segregationGO:004513230.023
blood vessel developmentGO:00015682460.023
stem cell proliferationGO:007208940.023
response to glucoseGO:000974930.023
dorsal ventral pattern formationGO:00099531250.023
exocytosisGO:000688710.023
cellular response to nutrient levelsGO:003166920.023
deathGO:00162651210.023
cellular protein catabolic processGO:004425740.023
cell morphogenesisGO:00009022890.023
positive regulation of cytoskeleton organizationGO:005149530.023
antimicrobial humoral responseGO:001973020.023
response to glucocorticoidGO:005138410.023
response to drugGO:004249330.023
positive regulation of metabolic processGO:00098931080.023
cellular response to lipopolysaccharideGO:007122230.022
positive regulation of immune effector processGO:000269930.022
compound eye developmentGO:004874920.022
cytokinesisGO:000091030.022
nuclear exportGO:005116810.022
negative regulation of mapk cascadeGO:004340940.022
locomotionGO:00400113130.022
positive regulation of canonical wnt signaling pathwayGO:009026340.022
centrosome cycleGO:000709810.022
specification of symmetryGO:00097992040.022
mononuclear cell proliferationGO:003294310.022
guanosine containing compound metabolic processGO:190106840.022
single organism membrane fusionGO:004480120.022
steroid hormone secretionGO:003592910.022
regulation of nucleoside metabolic processGO:000911820.022
regulation of biological qualityGO:00650082630.022
rna localizationGO:000640340.022
oxoacid metabolic processGO:0043436310.022
i kappab kinase nf kappab signalingGO:000724940.022
negative regulation of kinase activityGO:003367340.022
tissue remodelingGO:004877140.022
morphogenesis of an epitheliumGO:00020093330.022
cellular protein metabolic processGO:00442671290.022
regulation of myotube differentiationGO:001083020.022
cellular response to chemical stimulusGO:00708871570.022
response to carbohydrateGO:000974330.021
somatic muscle developmentGO:000752540.021
positive regulation of purine nucleotide catabolic processGO:003312310.021
negative regulation of epithelial cell proliferationGO:005068010.021
regulation of postsynaptic membrane potentialGO:006007810.021
internal peptidyl lysine acetylationGO:001839320.021
organic acid metabolic processGO:0006082310.021
apoptotic process involved in developmentGO:190274220.021
regulation of response to cytokine stimulusGO:006075930.021
meiosis iGO:000712710.021
positive regulation of cellular amino acid metabolic processGO:004576400.021
regulation of synapse assemblyGO:005196330.021
digestive tract morphogenesisGO:00485462310.021
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.021
angiogenesisGO:00015251580.021
positive regulation of nucleoside metabolic processGO:004597910.021
positive regulation of epithelial cell proliferationGO:005067910.021
positive regulation of protein polymerizationGO:003227320.021
energy reserve metabolic processGO:000611220.021
positive regulation of neuron apoptotic processGO:004352510.021
negative regulation of intracellular protein transportGO:009031730.021
regionalizationGO:00030022740.021
peptidyl threonine phosphorylationGO:001810710.021
positive regulation of cellular metabolic processGO:0031325940.021
localization of cellGO:00516742440.021
negative regulation of catabolic processGO:000989530.021
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.021
autophagyGO:000691440.020
secondary metabolic processGO:001974830.020
cell matrix adhesionGO:000716040.020
regulation of endothelial cell proliferationGO:000193610.020
gastrulationGO:00073692080.020
regulation of purine nucleotide catabolic processGO:003312120.020
guanosine containing compound catabolic processGO:190106920.020
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.020
symbiosis encompassing mutualism through parasitismGO:004440340.020
regulation of transcription from rna polymerase ii promoterGO:00063571140.020
cellular component movementGO:00069283350.020
transcription from rna polymerase ii promoterGO:0006366800.020
regulation of synaptic growth at neuromuscular junctionGO:000858210.020
regulation of transmembrane transporter activityGO:002289820.020
negative regulation of metabolic processGO:0009892860.020
regulation of tube sizeGO:003515020.020
muscle cell migrationGO:001481240.020
defense response to other organismGO:0098542330.020
regulation of cell differentiationGO:00455951420.020
positive regulation of neuron deathGO:190121610.020
programmed cell deathGO:00125011190.020
regulation of response to nutrient levelsGO:003210710.020
regulation of cell projection assemblyGO:006049140.020
ion transportGO:00068111140.020
response to xenobiotic stimulusGO:0009410450.020
regulation of protein bindingGO:004339330.020
small molecule metabolic processGO:0044281770.020
regulation of ion transmembrane transporter activityGO:003241220.020
positive regulation of apoptotic signaling pathwayGO:200123510.019
negative regulation of intracellular transportGO:003238730.019
astrocyte differentiationGO:004870810.019
embryonic skeletal system morphogenesisGO:0048704930.019
response to topologically incorrect proteinGO:003596620.019
neuron neuron synaptic transmissionGO:000727010.019
positive regulation of i kappab kinase nf kappab signalingGO:004312330.019
regulation of erythrocyte differentiationGO:004564620.019
carboxylic acid metabolic processGO:0019752220.019
embryonic skeletal system developmentGO:0048706970.019
adult behaviorGO:003053420.019
endocrine hormone secretionGO:006098620.019
proteolysis involved in cellular protein catabolic processGO:005160330.019
positive regulation of cellular amine metabolic processGO:003324000.019
cell morphogenesis involved in differentiationGO:00009041950.019
dna templated transcription initiationGO:000635210.019
regulation of transporter activityGO:003240920.019
peptide transportGO:001583310.019
muscle structure developmentGO:00610611960.019
camera type eye developmentGO:00430102220.019
cell motilityGO:00488702440.019
stem cell divisionGO:001714510.019
phosphorus metabolic processGO:00067931090.019
negative regulation of protein import into nucleusGO:004230820.019
regulation of blood vessel sizeGO:005088020.019
somite developmentGO:0061053960.019
positive regulation of map kinase activityGO:004340630.019
developmental programmed cell deathGO:001062340.019
regulation of neuronal synaptic plasticityGO:004816810.019
lymphocyte proliferationGO:004665110.018
positive regulation of cell activationGO:005086710.018
positive regulation of macromolecule metabolic processGO:0010604930.018
positive regulation of rna metabolic processGO:0051254590.018
protein secretionGO:000930610.018
hatching gland developmentGO:004878530.018
organelle fusionGO:004828430.018
regulation of inflammatory responseGO:005072720.018
p38mapk cascadeGO:003806610.018
immune responseGO:0006955280.018
negative regulation of nucleocytoplasmic transportGO:004682320.018
negative regulation of cytokine productionGO:000181810.018
positive regulation of striated muscle cell differentiationGO:005115510.018
regulation of protein modification by small protein conjugation or removalGO:190332030.018
positive regulation of dna metabolic processGO:005105410.018
organonitrogen compound metabolic processGO:1901564740.018
positive regulation of gene expressionGO:0010628710.018
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.018
toxin metabolic processGO:000940410.018
regulation of autophagyGO:001050630.018
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.018
cellular protein modification processGO:00064641000.018
regulation of muscle contractionGO:000693730.018
regulation of nucleotide catabolic processGO:003081120.018
mesenchyme developmentGO:00604851270.018
determination of left right symmetryGO:00073681790.018
b cell activationGO:004211320.018
multi organism cellular processGO:004476420.018
positive regulation of stress activated mapk cascadeGO:003287430.018
regulation of production of molecular mediator of immune responseGO:000270010.018
dicarboxylic acid transportGO:000683510.018
cell projection organizationGO:00300302840.018
cell projection morphogenesisGO:00488582440.018
reactive oxygen species metabolic processGO:007259360.017
cell part morphogenesisGO:00329902460.017
centrosome duplicationGO:005129810.017
intracellular signal transductionGO:0035556850.017
multicellular organismal metabolic processGO:004423620.017
regulation of gtp catabolic processGO:003312420.017
interspecies interaction between organismsGO:004441940.017
myeloid cell differentiationGO:0030099860.017
regulation of calcium ion transportGO:005192420.017
regulation of cell deathGO:00109411030.017
proteasomal protein catabolic processGO:001049820.017
neuron developmentGO:00486662620.017
golgi vesicle transportGO:004819330.017
response to light stimulusGO:0009416460.017
cation transportGO:0006812810.017
negative regulation of myeloid cell differentiationGO:004563810.017
cellular response to biotic stimulusGO:007121630.017
regulation of cell shapeGO:000836010.017
reactive nitrogen species metabolic processGO:200105700.017
cell proliferationGO:0008283800.017
regulation of dna replicationGO:000627530.017
modification dependent protein catabolic processGO:001994130.017
signal transduction in absence of ligandGO:003803410.017
protein acetylationGO:000647320.017
glial cell migrationGO:000834730.017
regulation of skeletal muscle tissue developmentGO:004864140.017
regulation of organ growthGO:004662030.017
ameboidal type cell migrationGO:00016671430.017
response to external stimulusGO:00096052640.017
positive regulation of nucleotide catabolic processGO:003081310.017
b cell differentiationGO:003018310.016
macromolecular complex disassemblyGO:003298410.016
carbohydrate biosynthetic processGO:001605110.016
skeletal muscle tissue developmentGO:0007519670.016
positive regulation of striated muscle tissue developmentGO:004584410.016
negative regulation of cellular catabolic processGO:003133030.016
actin filament based movementGO:003004810.016
superoxide metabolic processGO:000680120.016
protein acylationGO:004354330.016
endosomal transportGO:001619720.016
regulation of receptor activityGO:001046920.016
lateral inhibitionGO:004633110.016
protein complex disassemblyGO:004324110.016
monoamine transportGO:001584410.016
hematopoietic or lymphoid organ developmentGO:00485341910.016
fertilizationGO:000956630.016
entrainment of circadian clockGO:000964920.016
positive regulation of cellular biosynthetic processGO:0031328680.016
amino acid transportGO:000686520.016
regulation of cellular response to oxidative stressGO:190040720.016
protein modification processGO:00362111000.016
primitive hemopoiesisGO:0060215270.016
response to bacteriumGO:0009617580.016
nucleic acid transportGO:005065720.016
positive regulation of translationGO:004572710.016
viral processGO:001603210.016
pyruvate metabolic processGO:000609010.016
negative regulation of cell communicationGO:0010648960.016
eye morphogenesisGO:00485921440.016
positive regulation of gtp catabolic processGO:003312610.016
regulation of erk1 and erk2 cascadeGO:007037240.016
negative regulation of map kinase activityGO:004340720.016
reactive oxygen species biosynthetic processGO:190340910.016
peptide metabolic processGO:000651810.016
positive regulation of macromolecule biosynthetic processGO:0010557590.016
positive regulation of biosynthetic processGO:0009891680.016
cellular response to starvationGO:000926710.016
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.016
negative regulation of response to stimulusGO:00485851040.016
calcium mediated signalingGO:001972220.016
cell cycle arrestGO:000705010.016
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.015
response to oxygen radicalGO:000030520.015
positive regulation of wound healingGO:009030310.015
actin polymerization or depolymerizationGO:000815420.015
inner ear developmentGO:00488391260.015
positive regulation of muscle organ developmentGO:004863610.015
regulation of protein ubiquitinationGO:003139630.015
monocyte differentiationGO:003022420.015
cortical cytoskeleton organizationGO:003086510.015
bmp signaling pathwayGO:0030509520.015
blood circulationGO:0008015870.015
anterior posterior pattern specificationGO:00099521520.015
modulation by virus of host morphology or physiologyGO:001904810.015
wound healingGO:0042060900.015
regulation of cytokine mediated signaling pathwayGO:000195930.015
internal protein amino acid acetylationGO:000647520.015
multi organism processGO:00517041340.015
catechol containing compound metabolic processGO:000971220.015
regulation of stem cell proliferationGO:007209120.015
muscle tissue developmentGO:00605371100.015
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.015
sensory organ morphogenesisGO:00905962000.015
female sex differentiationGO:004666040.015
positive regulation of gtpase activityGO:004354710.015
nitric oxide metabolic processGO:004620920.015
multicellular organismal response to stressGO:003355520.015
negative regulation of ras protein signal transductionGO:004658010.015
regulation of protein polymerizationGO:003227120.015
defense responseGO:0006952470.015
regulation of apoptotic processGO:0042981980.015
spindle assemblyGO:005122520.015
skeletal system morphogenesisGO:00487051020.015
regulation of response to extracellular stimulusGO:003210410.015
protein depolymerizationGO:005126110.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.015
somitogenesisGO:0001756870.015
germ line stem cell maintenanceGO:003071820.015
cytoskeleton dependent cytokinesisGO:006164030.015
response to woundingGO:00096111160.015
regulation of skeletal muscle fiber developmentGO:004874220.015
lipid homeostasisGO:005508830.015
fat soluble vitamin metabolic processGO:000677540.015
protein complex localizationGO:003150310.015
circadian regulation of gene expressionGO:003292280.015
heart morphogenesisGO:00030071560.015
neurotransmitter transportGO:000683620.015
regulation of gtpase activityGO:004308720.015
olfactory lobe developmentGO:002198840.015
b cell mediated immunityGO:001972430.015
regulation of programmed cell deathGO:00430671010.015

si:dkey-177e13.4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.043
musculoskeletal system diseaseDOID:1700.023
immune system diseaseDOID:291400.018
disease of metabolismDOID:001466700.017
nervous system diseaseDOID:86300.017
cardiovascular system diseaseDOID:128700.016