Danio rerio

0 known processes

tle2

transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)

(Aliases: wu:fb96a10,wu:fc18h03,si:ch211-81i17.1)

tle2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.058
agingGO:000756820.046
positive regulation of cellular component biogenesisGO:004408930.045
morphogenesis of an epitheliumGO:00020093330.044
signal transductionGO:00071654550.042
Fly
nitrogen compound metabolic processGO:00068073190.041
Fly
positive regulation of transportGO:005105020.041
phagocytosisGO:000690930.040
establishment of protein localization to organelleGO:007259440.038
cellular nitrogen compound metabolic processGO:00346412900.037
Fly
lipid storageGO:001991510.036
heterocycle metabolic processGO:00464832900.036
Fly
cellular macromolecule metabolic processGO:00442603910.036
Fly
female sex differentiationGO:004666040.036
adherens junction organizationGO:003433240.036
maintenance of locationGO:005123540.034
tube morphogenesisGO:00352393490.034
response to drugGO:004249330.034
regulation of protein localization to nucleusGO:190018020.034
regulation of establishment of protein localizationGO:007020140.034
regulation of response to stimulusGO:00485832690.034
Fly
regulation of nitrogen compound metabolic processGO:00511712510.033
Fly
aromatic compound biosynthetic processGO:00194382170.033
Fly
negative regulation of biological processGO:00485193040.033
Fly
extrinsic apoptotic signaling pathwayGO:009719130.033
cell surface receptor signaling pathwayGO:00071663250.032
Fly
cellular aromatic compound metabolic processGO:00067252950.032
Fly
cellular component biogenesisGO:00440851780.032
cell projection organizationGO:00300302840.031
Fly
macromolecule biosynthetic processGO:00090592270.030
Fly
regulation of protein complex assemblyGO:004325430.030
regulation of cellular macromolecule biosynthetic processGO:20001122220.030
Fly
nucleobase containing compound metabolic processGO:00061392740.030
Fly
single organism nuclear importGO:190259330.030
establishment of localizationGO:00512342440.030
regulation of macromolecule metabolic processGO:00602553170.030
Fly
mononuclear cell proliferationGO:003294310.029
regulation of biological qualityGO:00650082630.029
Zebrafish
organic substance biosynthetic processGO:19015762890.029
Zebrafish Fly
nuclear transportGO:005116940.029
amine metabolic processGO:000930820.029
autophagyGO:000691440.029
regulation of cell communicationGO:00106462320.029
Fly
cell morphogenesisGO:00009022890.029
Fly
multicellular organism growthGO:003526440.028
protein targeting to nucleusGO:004474430.028
cellular macromolecule biosynthetic processGO:00346452240.028
Fly
regulation of protein transportGO:005122330.028
guanosine containing compound metabolic processGO:190106840.028
cell projection morphogenesisGO:00488582440.028
Fly
rna metabolic processGO:00160702190.028
Fly
single organism organelle organizationGO:19025891990.027
Fly
organic cyclic compound metabolic processGO:19013603010.027
Fly
immune system processGO:00023762410.027
leukocyte proliferationGO:007066110.027
regulation of dna replicationGO:000627530.027
response to chemicalGO:00422213200.027
cognitionGO:005089010.027
organelle organizationGO:00069962270.027
Fly
negative regulation of protein phosphorylationGO:000193340.027
nucleic acid metabolic processGO:00903042440.027
Fly
regulation of autophagyGO:001050630.027
protein localization to nucleusGO:003450430.026
cellular component morphogenesisGO:00329893360.026
Fly
ribonucleoside monophosphate catabolic processGO:000915840.026
positive regulation of protein complex assemblyGO:003133420.026
response to stressGO:00069502630.026
central nervous system developmentGO:00074173870.025
mitochondrion organizationGO:000700540.025
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.025
generation of neuronsGO:00486993850.025
Fly
lymphocyte proliferationGO:004665110.024
nucleocytoplasmic transportGO:000691340.024
nuclear importGO:005117030.024
regulation of multicellular organism growthGO:004001440.024
sensory organ developmentGO:00074233930.024
biosynthetic processGO:00090582940.024
Zebrafish Fly
regulation of cellular amino acid metabolic processGO:000652100.024
cellular amine metabolic processGO:004410620.024
cell part morphogenesisGO:00329902460.024
Fly
regulation of signalingGO:00230512350.024
Fly
nucleic acid templated transcriptionGO:00976591810.024
Fly
regulation of mrna processingGO:005068430.024
regulation of metal ion transportGO:001095940.024
regulation of cellular metabolic processGO:00313233200.024
Zebrafish Fly
positive regulation of cell cycleGO:004578730.024
regulation of cell activationGO:005086510.024
regulation of macromolecule biosynthetic processGO:00105562250.024
Fly
cellular biosynthetic processGO:00442492860.024
Zebrafish Fly
single organism localizationGO:19025782250.024
gtp metabolic processGO:004603940.024
digestive system developmentGO:00551232890.024
response to external stimulusGO:00096052640.023
cellular component assemblyGO:00226071700.023
cell matrix adhesionGO:000716040.023
regulation of rna biosynthetic processGO:20011412130.023
Fly
negative regulation of cellular processGO:00485232830.023
Fly
cell substrate adhesionGO:003158940.023
purine ribonucleoside monophosphate catabolic processGO:000916940.023
regulation of intracellular protein transportGO:003315730.023
protein importGO:001703830.023
cellular nitrogen compound biosynthetic processGO:00442712180.023
Fly
protein metabolic processGO:00195381830.023
positive regulation of catabolic processGO:000989640.023
protein import into nucleusGO:000660630.023
regulation of protein targetingGO:190353320.023
regulation of gene expressionGO:00104682650.023
Fly
cellular response to nutrient levelsGO:003166920.023
regulation of synapse assemblyGO:005196330.023
stem cell maintenanceGO:001982740.022
regulation of protein import into nucleusGO:004230620.022
synaptic growth at neuromuscular junctionGO:005112420.022
regulation of signal transductionGO:00099662250.022
Fly
regulation of rna metabolic processGO:00512522240.022
Fly
regulation of biosynthetic processGO:00098892500.022
Zebrafish Fly
transcription dna templatedGO:00063511810.022
Fly
heterocycle biosynthetic processGO:00181302150.022
Fly
cellular component movementGO:00069283350.022
actin polymerization or depolymerizationGO:000815420.021
regulation of cytokine productionGO:000181730.021
negative regulation of catabolic processGO:000989530.021
cellular response to extracellular stimulusGO:003166820.021
regulation of nucleobase containing compound metabolic processGO:00192192500.021
Fly
response to nutrientGO:000758430.021
convergent extensionGO:00600261180.021
regulation of cellular amine metabolic processGO:003323800.021
locomotionGO:00400113130.021
regulation of reproductive processGO:200024140.021
single organism transportGO:00447652060.021
regulation of cell shapeGO:000836010.021
signal transduction in absence of ligandGO:003803410.021
regulation of meiotic cell cycleGO:005144510.021
regulation of extrinsic apoptotic signaling pathwayGO:200123630.021
vasculature developmentGO:00019442780.021
regulation of synapse organizationGO:005080730.020
cellular response to chemical stimulusGO:00708871570.020
cell cycle g1 s phase transitionGO:004484310.020
eye developmentGO:00016542770.020
gtp catabolic processGO:000618420.020
protein polymerizationGO:005125840.020
regulation of protein catabolic processGO:004217610.020
cellular carbohydrate metabolic processGO:004426240.020
ubiquitin dependent protein catabolic processGO:000651130.020
proteolysis involved in cellular protein catabolic processGO:005160330.020
meiotic nuclear divisionGO:000712640.020
heart developmentGO:00075073130.020
regulation of primary metabolic processGO:00800903110.020
Zebrafish Fly
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.020
development of primary female sexual characteristicsGO:004654540.020
regulation of nucleocytoplasmic transportGO:004682220.020
purine nucleoside monophosphate catabolic processGO:000912840.020
protein heterooligomerizationGO:005129110.020
cellular response to starvationGO:000926710.019
single organism metabolic processGO:00447102170.019
Zebrafish
positive regulation of biological processGO:00485182530.019
positive regulation of cytoskeleton organizationGO:005149530.019
transportGO:00068102200.019
regulation of cytoplasmic transportGO:190364940.019
g1 s transition of mitotic cell cycleGO:000008210.019
cellular protein catabolic processGO:004425740.019
digestive tract developmentGO:00485652650.019
specification of symmetryGO:00097992040.019
regulation of transcription dna templatedGO:00063552130.019
Fly
cellular component disassemblyGO:002241110.019
guanosine containing compound catabolic processGO:190106920.019
convergent extension involved in gastrulationGO:0060027710.019
atp catabolic processGO:000620040.019
regulation of cellular ketone metabolic processGO:001056570.019
Zebrafish
carboxylic acid catabolic processGO:004639530.019
positive regulation of cellular amine metabolic processGO:003324000.019
cell migrationGO:00164772370.019
modification dependent macromolecule catabolic processGO:004363230.018
organic acid catabolic processGO:001605430.018
modification dependent protein catabolic processGO:001994130.018
phosphatidylinositol mediated signalingGO:004801520.018
single organism membrane fusionGO:004480120.018
regulation of developmental processGO:00507932470.018
positive regulation of cellular catabolic processGO:003133130.018
organelle fusionGO:004828430.018
brain developmentGO:00074202930.018
germ line stem cell maintenanceGO:003071820.018
rna biosynthetic processGO:00327741810.018
Fly
nucleobase containing compound biosynthetic processGO:00346542050.018
Fly
regulation of multicellular organismal processGO:00512392770.018
regulation of bindingGO:005109830.018
regulation of neural precursor cell proliferationGO:200017730.018
neuron differentiationGO:00301823530.018
Fly
hematopoietic or lymphoid organ developmentGO:00485341910.018
carboxylic acid metabolic processGO:0019752220.018
Zebrafish
determination of bilateral symmetryGO:00098552040.018
peptidyl lysine acetylationGO:001839420.017
digestive tract morphogenesisGO:00485462310.017
organonitrogen compound metabolic processGO:1901564740.017
female gonad developmentGO:000858540.017
immune system developmentGO:00025201910.017
adult behaviorGO:003053420.017
gene expressionGO:00104672520.017
Fly
gastrulationGO:00073692080.017
negative regulation of protein kinase activityGO:000646940.017
response to glucoseGO:000974930.017
positive regulation of cellular amino acid metabolic processGO:004576400.017
head developmentGO:00603223030.017
regulation of synaptic growth at neuromuscular junctionGO:000858210.017
negative regulation of kinase activityGO:003367340.017
protein localization to plasma membraneGO:007265910.017
organelle assemblyGO:00709251100.017
cell motilityGO:00488702440.017
blood vessel morphogenesisGO:00485142160.016
small molecule catabolic processGO:004428230.016
regulation of inflammatory responseGO:005072720.016
cytokinesisGO:000091030.016
response to carbohydrateGO:000974330.016
positive regulation of cell activationGO:005086710.016
toll like receptor signaling pathwayGO:000222440.016
response to monosaccharideGO:003428430.016
blood vessel developmentGO:00015682460.016
regulation of metabolic processGO:00192223590.016
Zebrafish Fly
positive regulation of cellular processGO:00485222010.016
regulation of peptidyl tyrosine phosphorylationGO:005073010.016
programmed cell deathGO:00125011190.016
angiogenesisGO:00015251580.016
liver developmentGO:0001889960.015
phagocytosis engulfmentGO:000691110.015
cellular response to oxygen levelsGO:007145310.015
regulation of cellular biosynthetic processGO:00313262450.015
Zebrafish Fly
microtubule organizing center organizationGO:003102310.015
cellular amino acid metabolic processGO:000652070.015
actin filament polymerizationGO:003004120.015
organic cyclic compound biosynthetic processGO:19013622230.015
Fly
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.015
centrosome organizationGO:005129710.015
cellular response to organic substanceGO:00713101050.015
protein acetylationGO:000647320.015
determination of left right symmetryGO:00073681790.015
localization of cellGO:00516742440.015
phosphatidylinositol 3 kinase signalingGO:001406520.015
sphingolipid biosynthetic processGO:003014820.015
stem cell proliferationGO:007208940.015
cellular ketone metabolic processGO:0042180110.015
Zebrafish
deathGO:00162651210.015
membrane fusionGO:006102520.015
ameboidal type cell migrationGO:00016671430.015
negative regulation of mapk cascadeGO:004340940.015
cell morphogenesis involved in differentiationGO:00009041950.015
Fly
response to vitaminGO:003327330.015
negative regulation of nitrogen compound metabolic processGO:0051172590.015
Fly
negative regulation of signalingGO:0023057960.015
Fly
negative regulation of cytoplasmic transportGO:190365020.015
intracellular signal transductionGO:0035556850.015
hemopoiesisGO:00300971830.015
regulation of nucleoside metabolic processGO:000911820.014
positive regulation of cell adhesionGO:004578510.014
primary neural tube formationGO:001402010.014
regulation of multicellular organismal developmentGO:20000262230.014
cytoskeleton organizationGO:0007010960.014
Fly
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.014
organic acid metabolic processGO:0006082310.014
Zebrafish
macroautophagyGO:001623610.014
embryonic organ developmentGO:00485683810.014
rna localizationGO:000640340.014
protein homooligomerizationGO:005126030.014
oxoacid metabolic processGO:0043436310.014
Zebrafish
small molecule metabolic processGO:0044281770.014
Zebrafish
negative regulation of defense responseGO:003134820.014
negative regulation of intracellular transportGO:003238730.014
inositol lipid mediated signalingGO:004801720.014
macromolecular complex disassemblyGO:003298410.014
response to abiotic stimulusGO:00096281220.014
neuron developmentGO:00486662620.014
Fly
regulation of carbohydrate metabolic processGO:000610940.014
production of molecular mediator of immune responseGO:000244020.014
proteasomal protein catabolic processGO:001049820.014
macromolecule modificationGO:00434121110.014
negative regulation of cytokine productionGO:000181810.014
response to hexoseGO:000974630.014
locomotor rhythmGO:004547530.014
negative regulation of ras protein signal transductionGO:004658010.014
homeostatic processGO:00425921420.014
tube closureGO:006060610.014
mitochondrial transportGO:000683920.014
chordate embryonic developmentGO:00430092710.014
transcription from rna polymerase ii promoterGO:0006366800.014
Fly
membrane lipid biosynthetic processGO:004646720.014
gland developmentGO:00487321430.014
regionalizationGO:00030022740.014
positive regulation of stress activated mapk cascadeGO:003287430.014
glucose homeostasisGO:004259310.014
secondary metabolic processGO:001974830.014
negative regulation of response to stimulusGO:00485851040.014
Fly
positive regulation of secretionGO:005104710.014
peptide transportGO:001583310.013
neuroblast proliferationGO:000740520.013
protein complex disassemblyGO:004324110.013
negative regulation of protein transportGO:005122430.013
retina development in camera type eyeGO:00600411460.013
phosphorus metabolic processGO:00067931090.013
wnt signaling pathwayGO:0016055800.013
Fly
positive regulation of dna metabolic processGO:005105410.013
macromolecular complex subunit organizationGO:0043933740.013
Fly
protein modification processGO:00362111000.013
cell deathGO:00082191210.013
protein secretionGO:000930610.013
fatty acid oxidationGO:001939510.013
lipid catabolic processGO:001604240.013
i kappab kinase nf kappab signalingGO:000724940.013
positive regulation of immune effector processGO:000269930.013
cell projection assemblyGO:0030031640.013
cellular response to external stimulusGO:007149620.013
regulation of transporter activityGO:003240920.013
regulation of stem cell differentiationGO:200073640.013
muscle structure developmentGO:00610611960.013
symbiosis encompassing mutualism through parasitismGO:004440340.013
regulation of epithelial cell proliferationGO:005067830.013
positive regulation of i kappab kinase nf kappab signalingGO:004312330.013
cellular protein metabolic processGO:00442671290.013
negative regulation of cellular catabolic processGO:003133030.013
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.013
rna 3 end processingGO:003112320.013
regulation of calcium ion transportGO:005192420.013
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.013
regulation of cellular carbohydrate metabolic processGO:001067540.013
internal protein amino acid acetylationGO:000647520.013
cellular component assembly involved in morphogenesisGO:00109271070.013
enzyme linked receptor protein signaling pathwayGO:00071671060.012
golgi vesicle transportGO:004819330.012
regulation of response to biotic stimulusGO:000283120.012
regulation of purine nucleotide catabolic processGO:003312120.012
monocarboxylic acid catabolic processGO:007232930.012
negative regulation of protein serine threonine kinase activityGO:007190120.012
embryonic organ morphogenesisGO:00485622740.012
response to organic substanceGO:00100331530.012
regulation of nucleic acid templated transcriptionGO:19035062130.012
Fly
protein acylationGO:004354330.012
regulation of cell substrate adhesionGO:001081010.012
positive regulation of cytosolic calcium ion concentrationGO:000720440.012
regulation of programmed cell deathGO:00430671010.012
regulation of stem cell proliferationGO:007209120.012
regulation of production of molecular mediator of immune responseGO:000270010.012
embryo development ending in birth or egg hatchingGO:00097922710.012
sequestering of calcium ionGO:005120830.012
regulation of cell deathGO:00109411030.012
regulation of i kappab kinase nf kappab signalingGO:004312240.012
negative regulation of dna metabolic processGO:005105340.012
carbohydrate biosynthetic processGO:001605110.012
actin cytoskeleton organizationGO:0030036630.012
Fly
carbohydrate homeostasisGO:003350010.012
negative regulation of protein localization to nucleusGO:190018120.012
negative regulation of cell communicationGO:0010648960.012
Fly
camera type eye developmentGO:00430102220.012
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.012
sensory perception of painGO:001923310.012
negative regulation of metabolic processGO:0009892860.012
Fly
negative regulation of small gtpase mediated signal transductionGO:005105810.012
lipid homeostasisGO:005508830.012
lipid oxidationGO:003444010.012
response to corticosteroidGO:003196010.012
regulation of cellular component organizationGO:0051128860.012
regulation of nucleotide catabolic processGO:003081120.012
positive regulation of secretion by cellGO:190353210.012
response to uvGO:000941130.012
regulation of protein polymerizationGO:003227120.012
positive regulation of nucleotide catabolic processGO:003081310.012
cellular protein modification processGO:00064641000.012
myeloid cell differentiationGO:0030099860.011
regulation of sequestering of calcium ionGO:005128240.011
positive regulation of nitrogen compound metabolic processGO:0051173690.011
internal peptidyl lysine acetylationGO:001839320.011
cytoplasm organizationGO:000702840.011
protein polyubiquitinationGO:000020940.011
negative regulation of gene expressionGO:0010629650.011
Fly
cellular localizationGO:0051641970.011
nucleic acid transportGO:005065720.011
negative regulation of sequestering of calcium ionGO:005128340.011
response to other organismGO:0051707970.011
cellular response to hypoxiaGO:007145610.011
post embryonic organ developmentGO:004856940.011
regulation of microtubule cytoskeleton organizationGO:007050730.011
determination of heart left right asymmetryGO:00613711170.011
epithelial tube morphogenesisGO:00605621480.011
negative regulation of map kinase activityGO:004340720.011
eye morphogenesisGO:00485921440.011
fertilizationGO:000956630.011
apoptotic processGO:00069151160.011
regulation of anatomical structure morphogenesisGO:00226031300.011
regulation of bone mineralizationGO:003050020.011
negative regulation of nucleocytoplasmic transportGO:004682320.011
growthGO:00400071740.011
positive regulation of jnk cascadeGO:004633030.011
mrna 3 end processingGO:003112420.011
positive regulation of nucleoside metabolic processGO:004597910.011
immunoglobulin mediated immune responseGO:001606430.011
peptidyl serine phosphorylationGO:001810510.011
endosomal transportGO:001619720.011
renal system developmentGO:0072001940.011
meiotic cell cycle processGO:190304630.011
negative regulation of intracellular protein transportGO:009031730.011
apoptotic process involved in developmentGO:190274220.011
regulation of biomineral tissue developmentGO:007016720.011
regulation of gtpase activityGO:004308720.011
ion transportGO:00068111140.011
cellular response to growth factor stimulusGO:0071363390.011
b cell mediated immunityGO:001972430.010
membrane invaginationGO:001032410.010
nucleoside monophosphate catabolic processGO:000912540.010
axon developmentGO:00615641660.010
erk1 and erk2 cascadeGO:007037140.010
developmental growthGO:00485891660.010
regulation of cell developmentGO:00602841000.010
cellular response to decreased oxygen levelsGO:003629410.010
regulation of gtp catabolic processGO:003312420.010
positive regulation of cell divisionGO:005178120.010
cilium assemblyGO:0042384580.010
sequestering of metal ionGO:005123830.010
cell substrate junction assemblyGO:000704420.010
system processGO:00030081850.010
double strand break repair via homologous recombinationGO:000072410.010
osteoclast differentiationGO:003031610.010
phosphate containing compound metabolic processGO:00067961080.010
developmental programmed cell deathGO:001062340.010
b cell activationGO:004211320.010
positive regulation of chromatin modificationGO:190331010.010
cellular response to endogenous stimulusGO:0071495680.010
cilium morphogenesisGO:0060271850.010

tle2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.046
nervous system diseaseDOID:86300.018
disease of metabolismDOID:001466700.017
musculoskeletal system diseaseDOID:1700.015
cancerDOID:16200.014
disease of cellular proliferationDOID:1456600.014
organ system cancerDOID:005068600.014
cardiovascular system diseaseDOID:128700.013
inherited metabolic disorderDOID:65500.012
intrinsic cardiomyopathyDOID:006003600.011
cardiomyopathyDOID:005070000.011
myopathyDOID:42300.011
heart diseaseDOID:11400.011
muscular diseaseDOID:008000000.011
muscle tissue diseaseDOID:6600.011