Danio rerio

28 known processes

scn1a

sodium channel, voltage-gated, type I, alpha

(Aliases: Nav1.1,scn1Laa,zgc:55600,MGC55600,zgc:158596)

scn1a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell projection organizationGO:00300302840.479
Zebrafish
regulation of metabolic processGO:00192223590.311
cell part morphogenesisGO:00329902460.258
Zebrafish
cell projection morphogenesisGO:00488582440.252
Zebrafish
central nervous system developmentGO:00074173870.237
cation transmembrane transportGO:0098655650.232
single organism transportGO:00447652060.222
cellular component morphogenesisGO:00329893360.217
Zebrafish
inorganic cation transmembrane transportGO:0098662500.211
neuron projection morphogenesisGO:00488121610.208
Zebrafish
generation of neuronsGO:00486993850.202
Zebrafish
circadian sleep wake cycle processGO:002241020.196
transmembrane transportGO:00550851200.189
cognitionGO:005089010.188
signal transductionGO:00071654550.187
Mouse
circadian sleep wake cycle sleepGO:005080210.182
larval developmentGO:000216420.180
head developmentGO:00603223030.167
cell morphogenesis involved in neuron differentiationGO:00486671630.157
Zebrafish
brain developmentGO:00074202930.150
meiotic nuclear divisionGO:000712640.139
establishment of localizationGO:00512342440.138
regulation of cellular metabolic processGO:00313233200.138
axon developmentGO:00615641660.137
Zebrafish
sensory perception of chemical stimulusGO:000760630.133
smooth muscle contractionGO:000693920.132
ion transportGO:00068111140.131
nucleobase containing compound metabolic processGO:00061392740.129
cell morphogenesisGO:00009022890.118
Zebrafish
regulation of circadian rhythmGO:004275240.118
nuclear divisionGO:0000280230.113
organic substance transportGO:0071702580.112
neuron projection developmentGO:00311751800.111
Zebrafish
neuron developmentGO:00486662620.111
Zebrafish
transportGO:00068102200.111
regulation of macromolecule metabolic processGO:00602553170.103
cell morphogenesis involved in differentiationGO:00009041950.097
Zebrafish
regulation of response to stimulusGO:00485832690.095
response to transition metal nanoparticleGO:1990267280.091
circadian sleep wake cycleGO:004274520.090
developmental growth involved in morphogenesisGO:0060560860.090
multicellular organismal response to stressGO:003355520.088
Mouse
single organism localizationGO:19025782250.085
embryo development ending in birth or egg hatchingGO:00097922710.083
regulation of primary metabolic processGO:00800903110.080
response to external stimulusGO:00096052640.080
Zebrafish
striated muscle tissue developmentGO:00147061100.080
transcription dna templatedGO:00063511810.079
embryonic organ morphogenesisGO:00485622740.077
agingGO:000756820.077
heart developmentGO:00075073130.077
regulation of gene expressionGO:00104682650.076
embryonic organ developmentGO:00485683810.075
muscle tissue developmentGO:00605371100.075
deathGO:00162651210.073
Mouse
nucleobase containing compound biosynthetic processGO:00346542050.072
sensory perception of painGO:001923310.070
response to chemicalGO:00422213200.070
Zebrafish Mouse
regulation of synapse organizationGO:005080730.069
rna biosynthetic processGO:00327741810.069
regulation of nucleic acid templated transcriptionGO:19035062130.068
chordate embryonic developmentGO:00430092710.067
hematopoietic or lymphoid organ developmentGO:00485341910.067
negative regulation of response to stimulusGO:00485851040.066
monovalent inorganic cation transportGO:0015672420.065
regulation of anatomical structure morphogenesisGO:00226031300.065
regulation of multicellular organismal processGO:00512392770.064
regulation of reproductive processGO:200024140.063
neuron differentiationGO:00301823530.063
Zebrafish
cellular nitrogen compound metabolic processGO:00346412900.062
negative regulation of biological processGO:00485193040.061
indole containing compound metabolic processGO:004243020.061
cellular biosynthetic processGO:00442492860.059
regulation of multicellular organism growthGO:004001440.058
skeletal system developmentGO:00015011810.058
blood vessel developmentGO:00015682460.058
cellular nitrogen compound biosynthetic processGO:00442712180.058
rna metabolic processGO:00160702190.057
regulation of biological qualityGO:00650082630.057
Zebrafish Mouse
positive regulation of biological processGO:00485182530.053
synaptic growth at neuromuscular junctionGO:005112420.053
response to stressGO:00069502630.052
Mouse
multicellular organism growthGO:003526440.052
regulation of developmental processGO:00507932470.051
cell surface receptor signaling pathwayGO:00071663250.051
regionalizationGO:00030022740.050
organic cyclic compound metabolic processGO:19013603010.048
muscle cell developmentGO:00550011150.048
vasculature developmentGO:00019442780.047
female sex differentiationGO:004666040.047
regulation of phGO:000688530.047
regulation of transcription dna templatedGO:00063552130.045
regulation of molecular functionGO:0065009700.045
metal ion transportGO:0030001580.044
lymphocyte proliferationGO:004665110.044
cellular macromolecule metabolic processGO:00442603910.043
ion transmembrane transportGO:0034220910.043
regulation of nucleobase containing compound metabolic processGO:00192192500.042
positive regulation of exocytosisGO:004592110.042
negative regulation of metabolic processGO:0009892860.042
heterocycle metabolic processGO:00464832900.041
positive regulation of cellular processGO:00485222010.041
cellular response to dna damage stimulusGO:0006974240.040
cellular macromolecule biosynthetic processGO:00346452240.039
negative regulation of cellular processGO:00485232830.038
immune responseGO:0006955280.038
aromatic compound biosynthetic processGO:00194382170.037
response to inorganic substanceGO:0010035380.037
ventral spinal cord developmentGO:0021517350.037
response to metal ionGO:0010038340.036
cell cycleGO:0007049930.036
response to woundingGO:00096111160.036
muscle contractionGO:0006936180.035
positive regulation of transportGO:005105020.035
nucleic acid metabolic processGO:00903042440.035
cation transportGO:0006812810.035
regulation of circadian sleep wake cycleGO:004274910.035
oocyte maturationGO:000155640.035
regulation of cell activationGO:005086510.034
cellular protein modification processGO:00064641000.034
locomotionGO:00400113130.033
Zebrafish
regulation of nitrogen compound metabolic processGO:00511712510.033
heterocycle biosynthetic processGO:00181302150.033
cellular component biogenesisGO:00440851780.032
cell cell recognitionGO:000998810.032
protein localization to nucleusGO:003450430.031
protein kinase b signalingGO:004349190.031
cellular component assemblyGO:00226071700.031
regulation of cellular macromolecule biosynthetic processGO:20001122220.031
regulation of synaptic plasticityGO:004816710.030
mitochondrion organizationGO:000700540.030
protein metabolic processGO:00195381830.030
regulation of rna biosynthetic processGO:20011412130.030
developmental maturationGO:0021700340.030
catecholamine metabolic processGO:000658420.030
regulation of multicellular organismal developmentGO:20000262230.030
cellular component movementGO:00069283350.030
Zebrafish
response to oxygen levelsGO:0070482250.030
response to organic substanceGO:00100331530.030
cilium organizationGO:0044782710.030
nitrogen compound metabolic processGO:00068073190.029
regulation of macromolecule biosynthetic processGO:00105562250.029
regulation of rna metabolic processGO:00512522240.029
system processGO:00030081850.029
Zebrafish Mouse
axonogenesisGO:00074091520.028
Zebrafish
cellular response to oxygen levelsGO:007145310.028
muscle system processGO:0003012200.028
striated muscle cell differentiationGO:00511461290.028
cellular localizationGO:0051641970.028
development of primary female sexual characteristicsGO:004654540.028
gene expressionGO:00104672520.028
negative regulation of protein kinase b signalingGO:005189820.027
catechol containing compound metabolic processGO:000971220.027
organic cyclic compound biosynthetic processGO:19013622230.026
regulation of protein complex assemblyGO:004325430.026
protein phosphorylationGO:0006468470.025
regulation of circadian sleep wake cycle sleepGO:004518710.025
macromolecule biosynthetic processGO:00090592270.025
heart contractionGO:0060047710.025
regulation of signalingGO:00230512350.025
positive regulation of transcription dna templatedGO:0045893570.025
female gonad developmentGO:000858540.025
cellular response to organic substanceGO:00713101050.025
tissue regenerationGO:0042246740.024
negative regulation of reproductive processGO:200024230.024
blood vessel morphogenesisGO:00485142160.024
macromolecular complex assemblyGO:0065003350.023
cell adhesionGO:0007155400.023
phosphate containing compound metabolic processGO:00067961080.023
biosynthetic processGO:00090582940.023
regulation of establishment of protein localizationGO:007020140.023
maintenance of locationGO:005123540.022
organelle assemblyGO:00709251100.022
regulation of tube sizeGO:003515020.022
gtp catabolic processGO:000618420.022
sleepGO:003043110.021
pancreas developmentGO:0031016840.021
proteasomal protein catabolic processGO:001049820.021
regulation of phosphate metabolic processGO:0019220430.021
locomotory behaviorGO:0007626340.021
Zebrafish Mouse
female meiotic divisionGO:000714320.021
anterior posterior pattern specificationGO:00099521520.021
microtubule based movementGO:0007018330.020
adult behaviorGO:003053420.020
Mouse
cellular aromatic compound metabolic processGO:00067252950.020
positive regulation of nitrogen compound metabolic processGO:0051173690.020
negative regulation of dna recombinationGO:004591020.020
positive regulation of cellular catabolic processGO:003133130.020
eye developmentGO:00016542770.020
axon guidanceGO:0007411860.020
Zebrafish
meiotic cell cycle processGO:190304630.020
heart processGO:0003015710.020
response to radiationGO:0009314510.019
regulation of cell morphogenesis involved in differentiationGO:0010769380.019
endodermal cell fate determinationGO:000749320.019
regulation of protein kinase b signalingGO:005189680.019
neurological system processGO:0050877620.019
Zebrafish Mouse
regulation of autophagyGO:001050630.018
embryonic skeletal system developmentGO:0048706970.018
nuclear transportGO:005116940.018
regulation of dna replicationGO:000627530.018
skeletal system morphogenesisGO:00487051020.018
immune system processGO:00023762410.018
skin developmentGO:0043588540.018
organelle fissionGO:0048285230.017
inorganic ion transmembrane transportGO:0098660570.017
positive regulation of cytosolic calcium ion concentrationGO:000720440.017
regulation of cellular biosynthetic processGO:00313262450.017
camera type eye developmentGO:00430102220.017
regulation of cell differentiationGO:00455951420.017
response to amino acidGO:004320020.017
response to temperature stimulusGO:0009266150.017
cytokinesisGO:000091030.017
diencephalon developmentGO:0021536580.017
regulation of cytokine productionGO:000181730.016
tissue remodelingGO:004877140.016
growthGO:00400071740.016
positive regulation of secretionGO:005104710.016
morphogenesis of an epitheliumGO:00020093330.016
photoreceptor cell differentiationGO:0046530550.016
exocytosisGO:000688710.016
response to carbohydrateGO:000974330.016
regulation of purine nucleotide catabolic processGO:003312120.016
negative regulation of innate immune responseGO:004582420.016
protein complex biogenesisGO:0070271300.016
regulation of cell cycleGO:0051726520.016
astrocyte differentiationGO:004870810.016
peptide transportGO:001583310.016
spinal cord developmentGO:0021510460.016
positive regulation of nucleobase containing compound metabolic processGO:0045935690.016
phasic smooth muscle contractionGO:001482110.016
swim bladder maturationGO:004879650.015
protein modification processGO:00362111000.015
peptidyl serine modificationGO:001820920.015
motor neuron axon guidanceGO:0008045230.015
Zebrafish
response to foodGO:003209410.015
compound eye developmentGO:004874920.015
transmission of nerve impulseGO:0019226190.015
Zebrafish Mouse
negative regulation of signal transductionGO:0009968940.015
cellular response to organic cyclic compoundGO:0071407380.015
regulation of nucleoside metabolic processGO:000911820.015
transcription from rna polymerase ii promoterGO:0006366800.015
branching morphogenesis of a nerveGO:004875540.015
positive regulation of immune effector processGO:000269930.014
gabaergic neuron differentiationGO:009715420.014
forebrain developmentGO:0030900960.014
amine metabolic processGO:000930820.014
regulation of gtpase activityGO:004308720.014
regulation of receptor internalizationGO:000209020.014
negative regulation of protein complex assemblyGO:003133310.014
protein complex assemblyGO:0006461300.014
regulation of metal ion transportGO:001095940.014
cation homeostasisGO:0055080330.014
Mouse
response to endogenous stimulusGO:0009719830.014
dna metabolic processGO:0006259270.014
muscle cell differentiationGO:00426921390.014
cell motilityGO:00488702440.014
regulation of cellular response to stressGO:0080135200.014
neuroblast proliferationGO:000740520.014
regulation of neural precursor cell proliferationGO:200017730.014
intracellular signal transductionGO:0035556850.014
Mouse
sensory organ developmentGO:00074233930.014
regulation of biosynthetic processGO:00098892500.013
enzyme linked receptor protein signaling pathwayGO:00071671060.013
renal system developmentGO:0072001940.013
blood circulationGO:0008015870.013
homeostatic processGO:00425921420.013
Mouse
apoptotic processGO:00069151160.013
Mouse
cell fate commitmentGO:0045165990.013
nuclear importGO:005117030.013
gamete generationGO:0007276330.013
regulation of transcription from rna polymerase ii promoterGO:00063571140.013
localization of cellGO:00516742440.013
stem cell proliferationGO:007208940.013
cellular response to extracellular stimulusGO:003166820.013
leukocyte proliferationGO:007066110.013
regulation of dendrite morphogenesisGO:004881430.013
cell fate specificationGO:0001708680.013
embryonic skeletal joint developmentGO:007249830.013
retinal ganglion cell axon guidanceGO:0031290350.013
neuron neuron synaptic transmissionGO:000727010.013
circulatory system processGO:0003013870.013
exocrine system developmentGO:0035272280.012
cellular protein catabolic processGO:004425740.012
negative regulation of multicellular organismal processGO:0051241690.012
cellular response to decreased oxygen levelsGO:003629410.012
regulation of gtp catabolic processGO:003312420.012
programmed cell deathGO:00125011190.012
Mouse
spermatid developmentGO:000728620.012
cellular response to chemical stimulusGO:00708871570.012
swimming behaviorGO:003626980.012
Zebrafish
regulation of stem cell proliferationGO:007209120.012
regulation of receptor mediated endocytosisGO:004825940.012
ubiquitin dependent protein catabolic processGO:000651130.012
ion homeostasisGO:0050801410.012
Mouse
cellular amine metabolic processGO:004410620.012
regulation of cell maturationGO:190342910.012
chemosensory behaviorGO:000763510.012
cell maturationGO:0048469230.012
establishment of localization in cellGO:0051649770.012
taxisGO:00423301090.012
Zebrafish
skeletal muscle organ developmentGO:0060538780.012
positive regulation of phospholipase c activityGO:001086310.012
regulation of muscle contractionGO:000693730.012
developmental growthGO:00485891660.012
cellular response to hypoxiaGO:007145610.012
cellular macromolecular complex assemblyGO:0034622240.012
cellular response to starvationGO:000926710.012
positive regulation of catabolic processGO:000989640.012
reproductive processGO:0022414400.012
nucleic acid templated transcriptionGO:00976591810.011
epiboly involved in gastrulation with mouth forming secondGO:0055113350.011
apoptotic signaling pathwayGO:0097190230.011
Mouse
negative regulation of multi organism processGO:004390130.011
regulation of transportGO:0051049450.011
cell cell signalingGO:0007267520.011
protein complex subunit organizationGO:0071822460.011
angiogenesisGO:00015251580.011
catechol containing compound biosynthetic processGO:000971320.011
protein localizationGO:0008104400.011
embryonic skeletal system morphogenesisGO:0048704930.011
phenol containing compound biosynthetic processGO:004618940.011
regulation of reactive oxygen species metabolic processGO:200037720.011
regulation of neurogenesisGO:0050767870.011
neuromuscular synaptic transmissionGO:000727420.011
circadian rhythmGO:0007623190.011
regulation of phosphorus metabolic processGO:0051174430.011
cell differentiation in spinal cordGO:0021515400.011
single organism behaviorGO:0044708240.011
Zebrafish Mouse
cellular response to nutrient levelsGO:003166920.011
g1 s transition of mitotic cell cycleGO:000008210.011
trabecula morphogenesisGO:006138320.011
negative regulation of kinase activityGO:003367340.011
dicarboxylic acid metabolic processGO:004364810.011
response to hydrogen peroxideGO:004254230.011
pole plasm assemblyGO:000731540.011
protein secretionGO:000930610.011
response to estrogenGO:0043627270.011
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.011
mitotic cell cycle processGO:1903047480.011
embryonic hemopoiesisGO:0035162530.011
guanosine containing compound catabolic processGO:190106920.010
cellular response to toxic substanceGO:009723710.010
response to decreased oxygen levelsGO:0036293250.010
apoptotic process involved in developmentGO:190274220.010
er nucleus signaling pathwayGO:000698420.010
positive regulation of cell differentiationGO:0045597300.010
regulation of dendrite developmentGO:005077330.010
dephosphorylationGO:0016311110.010
negative regulation of macromolecule metabolic processGO:0010605760.010
peptidyl threonine modificationGO:001821010.010
regulation of exocytosisGO:001715710.010
regenerationGO:0031099910.010
protein importGO:001703830.010
regulation of nucleotide catabolic processGO:003081120.010
fertilizationGO:000956630.010
regulation of extrinsic apoptotic signaling pathwayGO:200123630.010
behaviorGO:0007610740.010
Zebrafish Mouse
regulation of vasculature developmentGO:1901342330.010
negative regulation of protein localization to nucleusGO:190018120.010
ras protein signal transductionGO:000726570.010
muscle structure developmentGO:00610611960.010
nerve developmentGO:0021675450.010
negative regulation of nitrogen compound metabolic processGO:0051172590.010
erk1 and erk2 cascadeGO:007037140.010

scn1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.105
organ system cancerDOID:005068600.023
disease of cellular proliferationDOID:1456600.023
cancerDOID:16200.023
disease of metabolismDOID:001466700.012
nervous system diseaseDOID:86300.011