Danio rerio

0 known processes

me2

malic enzyme 2, NAD(+)-dependent, mitochondrial

(Aliases: zgc:100941)

me2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.378
muscle cell differentiationGO:00426921390.304
generation of neuronsGO:00486993850.235
actin polymerization or depolymerizationGO:000815420.196
agingGO:000756820.196
actin filament polymerizationGO:003004120.184
regulation of cell projection assemblyGO:006049140.181
neuron differentiationGO:00301823530.173
muscle structure developmentGO:00610611960.166
maintenance of locationGO:005123540.153
cytokinesisGO:000091030.150
digestive tract developmentGO:00485652650.147
cell morphogenesisGO:00009022890.140
cell projection assemblyGO:0030031640.136
lamellipodium organizationGO:009758110.134
heart contractionGO:0060047710.131
regulation of biological qualityGO:00650082630.121
heart processGO:0003015710.117
muscle tissue developmentGO:00605371100.114
regulation of nucleobase containing compound metabolic processGO:00192192500.112
regulation of protein polymerizationGO:003227120.110
lipid storageGO:001991510.105
protein polymerizationGO:005125840.104
cellular component morphogenesisGO:00329893360.103
regulation of muscle contractionGO:000693730.103
regulation of protein depolymerizationGO:190187910.097
muscle cell developmentGO:00550011150.096
regulation of macromolecule metabolic processGO:00602553170.096
actomyosin structure organizationGO:0031032530.095
organic substance biosynthetic processGO:19015762890.091
regulation of nucleotide catabolic processGO:003081120.083
cellular component disassemblyGO:002241110.082
regulation of metabolic processGO:00192223590.078
cellular aromatic compound metabolic processGO:00067252950.078
muscle system processGO:0003012200.077
negative regulation of cellular processGO:00485232830.077
neuron developmentGO:00486662620.077
blood circulationGO:0008015870.076
cellular macromolecule metabolic processGO:00442603910.075
circulatory system processGO:0003013870.074
positive regulation of biological processGO:00485182530.073
striated muscle contractionGO:0006941120.073
positive regulation of transportGO:005105020.072
protein localization to plasma membraneGO:007265910.070
intracellular mrna localizationGO:000829810.070
positive regulation of cellular component biogenesisGO:004408930.069
positive regulation of cellular catabolic processGO:003133130.069
cell cycle g1 s phase transitionGO:004484310.069
myofibril assemblyGO:0030239480.068
regulation of cell projection organizationGO:0031344440.068
cellular component assemblyGO:00226071700.067
striated muscle cell differentiationGO:00511461290.066
lamellipodium assemblyGO:003003210.066
cell projection organizationGO:00300302840.066
regulation of cellular metabolic processGO:00313233200.065
nucleoside monophosphate catabolic processGO:000912540.064
heart developmentGO:00075073130.064
macromolecule biosynthetic processGO:00090592270.063
regulation of nucleoside metabolic processGO:000911820.061
negative regulation of biological processGO:00485193040.060
cytoskeleton organizationGO:0007010960.060
cardiac muscle cell developmentGO:0055013200.060
regulation of cell shapeGO:000836010.059
actin filament based processGO:0030029640.058
cellular component assembly involved in morphogenesisGO:00109271070.057
sequestering of metal ionGO:005123830.057
cellular nitrogen compound metabolic processGO:00346412900.056
regulation of multicellular organismal processGO:00512392770.054
organic cyclic compound metabolic processGO:19013603010.053
regulation of cellular component organizationGO:0051128860.053
protein complex disassemblyGO:004324110.053
somatic muscle developmentGO:000752540.053
establishment of protein localization to plasma membraneGO:009000210.052
regulation of primary metabolic processGO:00800903110.052
muscle contractionGO:0006936180.052
cellular macromolecule biosynthetic processGO:00346452240.051
ribonucleoside monophosphate catabolic processGO:000915840.051
cellular component biogenesisGO:00440851780.051
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.050
digestive system developmentGO:00551232890.049
single organism organelle organizationGO:19025891990.047
striated muscle cell developmentGO:00550021080.046
actin filament organizationGO:0007015150.046
nitrogen compound metabolic processGO:00068073190.046
system processGO:00030081850.045
regionalizationGO:00030022740.044
organelle organizationGO:00069962270.044
aromatic compound biosynthetic processGO:00194382170.044
eye developmentGO:00016542770.043
regulation of bindingGO:005109830.043
purine ribonucleoside monophosphate catabolic processGO:000916940.043
positive regulation of gtp catabolic processGO:003312610.043
locomotionGO:00400113130.042
embryo development ending in birth or egg hatchingGO:00097922710.041
positive regulation of muscle cell differentiationGO:005114910.041
regulation of gtp catabolic processGO:003312420.041
nucleic acid metabolic processGO:00903042440.041
rna localizationGO:000640340.040
g1 s transition of mitotic cell cycleGO:000008210.040
cardiac muscle cell differentiationGO:0055007300.040
regulation of multicellular organismal developmentGO:20000262230.039
cardiocyte differentiationGO:0035051440.039
regulation of developmental processGO:00507932470.039
regulation of filopodium assemblyGO:005148920.039
organelle assemblyGO:00709251100.038
growthGO:00400071740.038
segmentationGO:0035282970.038
striated muscle tissue developmentGO:00147061100.037
regulation of metal ion transportGO:001095940.037
macromolecular complex disassemblyGO:003298410.036
positive regulation of purine nucleotide catabolic processGO:003312310.036
regulation of protein complex assemblyGO:004325430.036
carboxylic acid catabolic processGO:004639530.035
regulation of protein complex disassemblyGO:004324410.035
regulation of cellular macromolecule biosynthetic processGO:20001122220.035
cellular macromolecular complex assemblyGO:0034622240.035
macromolecular complex subunit organizationGO:0043933740.035
purine nucleotide metabolic processGO:0006163270.035
cardiac muscle tissue developmentGO:0048738480.035
response to chemicalGO:00422213200.034
cardiac myofibril assemblyGO:005500390.034
regulation of purine nucleotide catabolic processGO:003312120.034
positive regulation of cellular processGO:00485222010.033
regulation of nitrogen compound metabolic processGO:00511712510.033
single organism localizationGO:19025782250.033
oocyte anterior posterior axis specificationGO:000731440.033
heterocycle metabolic processGO:00464832900.033
single organism transportGO:00447652060.032
sequestering of calcium ionGO:005120830.032
positive regulation of catabolic processGO:000989640.032
g2 m transition of mitotic cell cycleGO:000008640.032
actin cytoskeleton organizationGO:0030036630.032
regulation of heart contractionGO:0008016320.032
cardiac cell developmentGO:0055006210.031
regulation of gene expressionGO:00104682650.031
regulation of organelle assemblyGO:190211540.031
atp catabolic processGO:000620040.031
protein depolymerizationGO:005126110.030
blood vessel developmentGO:00015682460.030
nucleobase containing compound metabolic processGO:00061392740.030
fatty acid beta oxidationGO:000663510.030
establishment of localizationGO:00512342440.030
central nervous system developmentGO:00074173870.030
regulation of rna biosynthetic processGO:20011412130.030
cell morphogenesis involved in differentiationGO:00009041950.030
negative regulation of sequestering of calcium ionGO:005128340.030
regulation of protein bindingGO:004339330.030
cellular biosynthetic processGO:00442492860.029
cell morphogenesis involved in neuron differentiationGO:00486671630.029
regulation of cellular biosynthetic processGO:00313262450.029
regulation of anatomical structure morphogenesisGO:00226031300.029
cell projection morphogenesisGO:00488582440.029
regulation of cell substrate adhesionGO:001081010.028
regulation of gtpase activityGO:004308720.028
regulation of molecular functionGO:0065009700.028
brain developmentGO:00074202930.028
response to abiotic stimulusGO:00096281220.028
heart morphogenesisGO:00030071560.027
cardiac muscle contractionGO:006004860.027
positive regulation of nucleoside metabolic processGO:004597910.027
positive regulation of cell substrate adhesionGO:001081110.027
nucleobase containing compound biosynthetic processGO:00346542050.027
regulation of cell differentiationGO:00455951420.027
organonitrogen compound metabolic processGO:1901564740.027
cell cycleGO:0007049930.026
positive regulation of cell adhesionGO:004578510.026
modification dependent protein catabolic processGO:001994130.026
positive regulation of cell matrix adhesionGO:000195410.026
single organism metabolic processGO:00447102170.025
regulation of dendrite developmentGO:005077330.025
cellular protein complex assemblyGO:0043623190.025
regulation of sequestering of calcium ionGO:005128240.025
purine nucleoside monophosphate catabolic processGO:000912840.025
regulation of cytoskeleton organizationGO:0051493110.025
cell motilityGO:00488702440.024
fatty acid catabolic processGO:000906210.024
cell part morphogenesisGO:00329902460.024
transportGO:00068102200.024
biosynthetic processGO:00090582940.024
cellular component movementGO:00069283350.024
transcription dna templatedGO:00063511810.024
regulation of cell morphogenesisGO:0022604420.024
embryonic pattern specificationGO:0009880440.024
regulation of catalytic activityGO:0050790550.024
cardiac chamber developmentGO:0003205190.024
regulation of bone mineralizationGO:003050020.023
ubiquitin dependent protein catabolic processGO:000651130.023
small molecule metabolic processGO:0044281770.023
protein metabolic processGO:00195381830.023
regulation of rna metabolic processGO:00512522240.022
positive regulation of cytosolic calcium ion concentrationGO:000720440.022
neuron projection developmentGO:00311751800.022
cell cycle processGO:0022402530.022
cytoplasm organizationGO:000702840.022
guanosine containing compound metabolic processGO:190106840.022
fatty acid transportGO:001590810.022
cellular response to extracellular stimulusGO:003166820.022
regulation of cellular component sizeGO:0032535300.022
regulation of ion transmembrane transporter activityGO:003241220.021
adult behaviorGO:003053420.021
carbohydrate derivative metabolic processGO:1901135610.021
negative regulation of macromolecule metabolic processGO:0010605760.021
negative regulation of blood circulationGO:190352320.021
response to drugGO:004249330.021
multi organism processGO:00517041340.021
gtp metabolic processGO:004603940.021
regulation of actin filament based processGO:003297090.021
rna biosynthetic processGO:00327741810.021
heterocycle biosynthetic processGO:00181302150.021
positive regulation of nitrogen compound metabolic processGO:0051173690.021
catabolic processGO:0009056320.020
regulation of multicellular organism growthGO:004001440.020
gene expressionGO:00104672520.020
proteolysis involved in cellular protein catabolic processGO:005160330.020
modification dependent macromolecule catabolic processGO:004363230.020
protein complex subunit organizationGO:0071822460.020
protein targeting to membraneGO:000661210.020
response to stressGO:00069502630.020
regulation of cell developmentGO:00602841000.020
circadian sleep wake cycle sleepGO:005080210.020
cellular carbohydrate metabolic processGO:004426240.020
cellular protein metabolic processGO:00442671290.020
cation transmembrane transportGO:0098655650.019
negative regulation of protein phosphorylationGO:000193340.019
localization of cellGO:00516742440.019
gtp catabolic processGO:000618420.019
macromolecule localizationGO:0033036540.019
head developmentGO:00603223030.019
macromolecular complex assemblyGO:0065003350.019
positive regulation of nucleotide catabolic processGO:003081310.019
regulation of anatomical structure sizeGO:0090066330.019
positive regulation of macromolecule metabolic processGO:0010604930.019
nuclear importGO:005117030.019
inositol lipid mediated signalingGO:004801720.019
sarcomere organizationGO:0045214260.019
guanosine containing compound catabolic processGO:190106920.018
programmed cell deathGO:00125011190.018
regulation of synaptic growth at neuromuscular junctionGO:000858210.018
cellular response to nutrient levelsGO:003166920.018
organic acid metabolic processGO:0006082310.018
negative regulation of heart contractionGO:004582220.018
cellular protein complex disassemblyGO:004362410.018
phosphorus metabolic processGO:00067931090.018
regulation of reproductive processGO:200024140.018
multicellular organism growthGO:003526440.018
positive regulation of cytoskeleton organizationGO:005149530.018
regulation of sarcomere organizationGO:006029720.018
ameboidal type cell migrationGO:00016671430.018
cellular lipid catabolic processGO:004424230.017
positive regulation of map kinase activityGO:004340630.017
signal transductionGO:00071654550.017
regulation of nucleotide metabolic processGO:0006140170.017
synaptic growth at neuromuscular junctionGO:005112420.017
regulation of circadian rhythmGO:004275240.017
axis specificationGO:0009798430.017
positive regulation of gtpase activityGO:004354710.017
regulation of system processGO:0044057400.017
lipid homeostasisGO:005508830.017
cell substrate adhesionGO:003158940.017
cellular response to external stimulusGO:007149620.017
cellular amine metabolic processGO:004410620.017
long chain fatty acid transportGO:001590910.017
morphogenesis of an epitheliumGO:00020093330.017
cell surface receptor signaling pathwayGO:00071663250.017
amine metabolic processGO:000930820.016
enzyme linked receptor protein signaling pathwayGO:00071671060.016
cellular response to starvationGO:000926710.016
single organism cellular localizationGO:1902580460.016
anterior posterior pattern specificationGO:00099521520.016
release of sequestered calcium ion into cytosolGO:005120930.016
regulation of macromolecule biosynthetic processGO:00105562250.016
regulation of protein transportGO:005122330.016
neuron projection morphogenesisGO:00488121610.016
regulation of biosynthetic processGO:00098892500.016
proteasomal protein catabolic processGO:001049820.016
cellular response to chemical stimulusGO:00708871570.016
action potentialGO:0001508190.016
vasculature developmentGO:00019442780.016
protein importGO:001703830.016
inorganic ion transmembrane transportGO:0098660570.016
macromolecule modificationGO:00434121110.016
adherens junction assemblyGO:003433310.016
regulation of transmembrane transporter activityGO:002289820.015
regulation of cellular amino acid metabolic processGO:000652100.015
regulation of transporter activityGO:003240920.015
regulation of neuron differentiationGO:0045664560.015
oxoacid metabolic processGO:0043436310.015
homeostatic processGO:00425921420.015
spermatid differentiationGO:004851520.015
regulation of establishment of protein localizationGO:007020140.015
cell divisionGO:0051301200.015
ion transmembrane transportGO:0034220910.015
negative regulation of cytokine productionGO:000181810.015
membrane invaginationGO:001032410.015
cellular response to endogenous stimulusGO:0071495680.015
protein complex biogenesisGO:0070271300.015
cellular process involved in reproduction in multicellular organismGO:0022412280.015
blood vessel morphogenesisGO:00485142160.015
regulation of synapse assemblyGO:005196330.015
protein complex assemblyGO:0006461300.015
regulation of transcription dna templatedGO:00063552130.015
regulation of neurogenesisGO:0050767870.015
cellular nitrogen compound biosynthetic processGO:00442712180.015
negative regulation of cyclic nucleotide metabolic processGO:003080070.015
regulation of protein metabolic processGO:0051246560.015
gastrulationGO:00073692080.015
adherens junction organizationGO:003433240.015
embryonic organ developmentGO:00485683810.014
regulation of rho protein signal transductionGO:003502320.014
musculoskeletal movementGO:005088180.014
axon developmentGO:00615641660.014
regulation of synapse organizationGO:005080730.014
skeletal muscle tissue developmentGO:0007519670.014
oocyte developmentGO:0048599140.014
cognitionGO:005089010.014
response to endogenous stimulusGO:0009719830.014
nucleobase containing compound transportGO:001593120.014
regenerationGO:0031099910.014
positive regulation of cell cycleGO:004578730.014
response to external stimulusGO:00096052640.014
negative regulation of protein kinase activityGO:000646940.014
negative regulation of cellular component organizationGO:0051129160.014
hormone transportGO:000991420.014
organic cyclic compound biosynthetic processGO:19013622230.013
autophagyGO:000691440.013
regulation of epithelial cell proliferationGO:005067830.013
regulation of circadian sleep wake cycleGO:004274910.013
chordate embryonic developmentGO:00430092710.013
dna templated transcription elongationGO:000635430.013
positive regulation of secretion by cellGO:190353210.013
regulation of cellular ketone metabolic processGO:001056570.013
angiogenesisGO:00015251580.013
apoptotic processGO:00069151160.013
ribonucleoside triphosphate biosynthetic processGO:000920120.013
regulation of membrane potentialGO:0042391230.013
response to organic substanceGO:00100331530.013
regulation of autophagyGO:001050630.013
heart trabecula morphogenesisGO:006138420.013
lipid catabolic processGO:001604240.013
epithelial cell morphogenesisGO:000338220.013
lipid oxidationGO:003444010.013
somitogenesisGO:0001756870.013
deathGO:00162651210.013
circadian sleep wake cycleGO:004274520.013
body morphogenesisGO:0010171160.013
regulation of production of molecular mediator of immune responseGO:000270010.013
dorsal motor nucleus of vagus nerve developmentGO:002174440.013
startle responseGO:000196440.012
regulation of cardiac muscle contractionGO:005511720.012
positive regulation of cellular metabolic processGO:0031325940.012
cell cycle arrestGO:000705010.012
protein localization to nucleusGO:003450430.012
cytoskeleton dependent cytokinesisGO:006164030.012
skeletal muscle organ developmentGO:0060538780.012
regulation of hydrolase activityGO:0051336280.012
regulation of cell communicationGO:00106462320.012
meiotic nuclear divisionGO:000712640.012
regulation of striated muscle contractionGO:000694220.012
cytokinetic processGO:003250620.012
regulation of localizationGO:00328791040.012
response to corticosteroidGO:003196010.012
mononuclear cell proliferationGO:003294310.012
catecholamine metabolic processGO:000658420.012
dendrite developmentGO:001635890.012
positive regulation of secretionGO:005104710.012
catechol containing compound biosynthetic processGO:000971320.011
cell cycle g2 m phase transitionGO:004483940.011
regulation of cell activationGO:005086510.011
negative regulation of nitrogen compound metabolic processGO:0051172590.011
spermatid developmentGO:000728620.011
immune system processGO:00023762410.011
dorsal ventral pattern formationGO:00099531250.011
lymphocyte proliferationGO:004665110.011
pharynx developmentGO:006046550.011
cell substrate junction assemblyGO:000704420.011
regulation of mrna processingGO:005068430.011
cardiac atrium morphogenesisGO:000320920.011
organonitrogen compound biosynthetic processGO:1901566470.011
regulation of cellular protein metabolic processGO:0032268520.011
ventricular cardiac muscle cell developmentGO:005501550.011
regulation of cytoplasmic transportGO:190364940.011
rna metabolic processGO:00160702190.011
regulation of cell matrix adhesionGO:000195210.011
specification of symmetryGO:00097992040.011
oogenesisGO:0048477140.011
locomotor rhythmGO:004547530.011
protein targeting to nucleusGO:004474430.011
germ cell developmentGO:0007281220.011
compound eye developmentGO:004874920.011
cellular amino acid metabolic processGO:000652070.011
protein import into nucleusGO:000660630.011
positive regulation of developmental processGO:0051094500.011
positive regulation of striated muscle cell differentiationGO:005115510.011
cellular localizationGO:0051641970.011
protein stabilizationGO:005082120.011
oocyte differentiationGO:0009994140.011
digestive tract morphogenesisGO:00485462310.011
regulation of peptidyl tyrosine phosphorylationGO:005073010.011
single organism nuclear importGO:190259330.011
mitochondrial transportGO:000683920.010
regulation of cellular component biogenesisGO:0044087120.010
determination of bilateral symmetryGO:00098552040.010
transcription from rna polymerase ii promoterGO:0006366800.010
developmental maturationGO:0021700340.010
actin filament based movementGO:003004810.010
regulation of stem cell differentiationGO:200073640.010
cell deathGO:00082191210.010
regulation of neuron projection developmentGO:0010975400.010
purine ribonucleotide metabolic processGO:0009150270.010
protein secretionGO:000930610.010
angioblast cell migration involved in selective angioblast sproutingGO:003547540.010
phagocytosis engulfmentGO:000691110.010
female sex differentiationGO:004666040.010
establishment of protein localization to organelleGO:007259440.010
negative regulation of synapse assemblyGO:005196420.010
larval heart developmentGO:000750820.010
regulation of protein localization to nucleusGO:190018020.010
chemosensory behaviorGO:000763510.010
monocarboxylic acid catabolic processGO:007232930.010

me2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.168
musculoskeletal system diseaseDOID:1700.164
muscular diseaseDOID:008000000.164
muscle tissue diseaseDOID:6600.109
myopathyDOID:42300.109
cardiovascular system diseaseDOID:128700.027
disease of metabolismDOID:001466700.015
nervous system diseaseDOID:86300.012
heart diseaseDOID:11400.011
cardiomyopathyDOID:005070000.011