Danio rerio

13 known processes

a2ml

alpha-2-macroglobulin-like

a2ml biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of metabolic processGO:00192223590.242
Human Mouse
regulation of macromolecule metabolic processGO:00602553170.225
Human Mouse
negative regulation of cellular processGO:00485232830.213
Human Mouse
chordate embryonic developmentGO:00430092710.203
cellular macromolecule metabolic processGO:00442603910.197
Human Mouse
regulation of biosynthetic processGO:00098892500.185
response to external stimulusGO:00096052640.169
Human
regionalizationGO:00030022740.163
digestive tract morphogenesisGO:00485462310.161
gene expressionGO:00104672520.159
Human Mouse
nucleobase containing compound biosynthetic processGO:00346542050.149
head developmentGO:00603223030.149
regulation of primary metabolic processGO:00800903110.146
Human Mouse
skeletal system developmentGO:00015011810.144
regulation of biological qualityGO:00650082630.139
regulation of macromolecule biosynthetic processGO:00105562250.135
regulation of cellular macromolecule biosynthetic processGO:20001122220.130
tube morphogenesisGO:00352393490.129
regulation of gene expressionGO:00104682650.127
Human Mouse
response to chemicalGO:00422213200.125
response to stressGO:00069502630.123
Human
digestive system developmentGO:00551232890.122
biosynthetic processGO:00090582940.121
regulation of nitrogen compound metabolic processGO:00511712510.120
macromolecule biosynthetic processGO:00090592270.119
cellular biosynthetic processGO:00442492860.118
convergent extension involved in gastrulationGO:0060027710.118
central nervous system developmentGO:00074173870.116
cellular component morphogenesisGO:00329893360.116
single organism localizationGO:19025782250.115
regulation of nucleic acid templated transcriptionGO:19035062130.110
cellular nitrogen compound metabolic processGO:00346412900.109
heterocycle biosynthetic processGO:00181302150.105
regulation of rna biosynthetic processGO:20011412130.104
regulation of rna metabolic processGO:00512522240.103
digestive tract developmentGO:00485652650.100
regulation of transcription dna templatedGO:00063552130.099
sensory organ developmentGO:00074233930.098
regulation of localizationGO:00328791040.098
cell surface receptor signaling pathwayGO:00071663250.095
tissue remodelingGO:004877140.095
regulation of cellular biosynthetic processGO:00313262450.095
cellular response to extracellular stimulusGO:003166820.093
morphogenesis of an epitheliumGO:00020093330.092
cellular response to starvationGO:000926710.091
embryo development ending in birth or egg hatchingGO:00097922710.089
regulation of extrinsic apoptotic signaling pathwayGO:200123630.089
cellular aromatic compound metabolic processGO:00067252950.087
cellular component movementGO:00069283350.087
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.087
regulation of synapse organizationGO:005080730.085
response to nutrientGO:000758430.084
regulation of epithelial cell proliferationGO:005067830.083
cell morphogenesisGO:00009022890.082
positive regulation of map kinase activityGO:004340630.081
rna metabolic processGO:00160702190.081
transcription dna templatedGO:00063511810.079
cellular response to nutrient levelsGO:003166920.079
larval developmentGO:000216420.078
cell migrationGO:00164772370.078
signal transductionGO:00071654550.078
establishment of localizationGO:00512342440.077
cellular response to external stimulusGO:007149620.076
amine metabolic processGO:000930820.076
negative regulation of biological processGO:00485193040.075
Human Mouse
convergent extensionGO:00600261180.074
nucleic acid metabolic processGO:00903042440.071
extrinsic apoptotic signaling pathwayGO:009719130.071
liver developmentGO:0001889960.071
cellular macromolecule biosynthetic processGO:00346452240.070
cellular nitrogen compound biosynthetic processGO:00442712180.070
organic cyclic compound biosynthetic processGO:19013622230.069
organic cyclic compound metabolic processGO:19013603010.069
positive regulation of cellular processGO:00485222010.068
rna biosynthetic processGO:00327741810.068
aromatic compound biosynthetic processGO:00194382170.067
locomotionGO:00400113130.066
regulation of phGO:000688530.066
sequestering of calcium ionGO:005120830.066
regulation of response to stimulusGO:00485832690.064
Human
cation transportGO:0006812810.062
heterocycle metabolic processGO:00464832900.062
nucleic acid templated transcriptionGO:00976591810.062
regulation of synapse assemblyGO:005196330.061
synaptic growth at neuromuscular junctionGO:005112420.060
organic substance biosynthetic processGO:19015762890.060
cell motilityGO:00488702440.060
regulation of nucleobase containing compound metabolic processGO:00192192500.058
negative regulation of epithelial cell proliferationGO:005068010.057
neuron differentiationGO:00301823530.056
regulation of establishment of protein localizationGO:007020140.056
metal ion transportGO:0030001580.055
brain developmentGO:00074202930.055
ion transportGO:00068111140.055
regulation of cellular amino acid metabolic processGO:000652100.054
regulation of developmental processGO:00507932470.054
positive regulation of cellular component biogenesisGO:004408930.054
hepaticobiliary system developmentGO:0061008980.053
regulation of multicellular organismal developmentGO:20000262230.052
nucleobase containing compound metabolic processGO:00061392740.051
regulation of cellular metabolic processGO:00313233200.051
Human Mouse
response to alkaloidGO:004327920.049
regulation of hormone secretionGO:004688320.049
regulation of metal ion transportGO:001095940.048
cell migration involved in gastrulationGO:0042074790.047
transcription from rna polymerase ii promoterGO:0006366800.047
cell morphogenesis involved in differentiationGO:00009041950.047
regulation of transcription from rna polymerase ii promoterGO:00063571140.047
regulation of multicellular organismal processGO:00512392770.047
negative regulation of secretion by cellGO:190353120.046
nitrogen compound metabolic processGO:00068073190.046
regulation of peptidyl tyrosine phosphorylationGO:005073010.046
positive regulation of biological processGO:00485182530.046
Human
axon developmentGO:00615641660.045
dorsal ventral pattern formationGO:00099531250.045
positive regulation of transportGO:005105020.045
gas transportGO:001566930.044
transportGO:00068102200.044
negative regulation of secretionGO:005104820.044
single organism transportGO:00447652060.044
regulation of cellular amine metabolic processGO:003323800.044
ameboidal type cell migrationGO:00016671430.044
positive regulation of synapse assemblyGO:005196510.042
regulation of protein catabolic processGO:004217610.042
negative regulation of protein phosphorylationGO:000193340.042
multicellular organism growthGO:003526440.041
response to glucocorticoidGO:005138410.041
positive regulation of cytosolic calcium ion concentrationGO:000720440.041
transmembrane transportGO:00550851200.040
cell projection organizationGO:00300302840.040
regulation of sequestering of calcium ionGO:005128240.040
response to organic substanceGO:00100331530.040
determination of bilateral symmetryGO:00098552040.040
regulation of mrna processingGO:005068430.039
regulation of cellular component organizationGO:0051128860.039
activation of mapk activityGO:000018730.039
localization of cellGO:00516742440.039
cellular response to chemical stimulusGO:00708871570.038
response to amino acidGO:004320020.038
regulation of stem cell differentiationGO:200073640.038
response to organic cyclic compoundGO:0014070510.037
neuron projection morphogenesisGO:00488121610.037
response to woundingGO:00096111160.037
Human
regulation of signal transductionGO:00099662250.037
response to corticosteroidGO:003196010.037
embryonic organ developmentGO:00485683810.037
regulation of jun kinase activityGO:004350630.036
protein secretionGO:000930610.036
regulation of inflammatory responseGO:005072720.036
Human
system processGO:00030081850.036
regulation of cytokine productionGO:000181730.036
female sex differentiationGO:004666040.036
cellular amine metabolic processGO:004410620.036
somite developmentGO:0061053960.036
glucose importGO:004632320.035
neuromuscular synaptic transmissionGO:000727420.035
ion transmembrane transportGO:0034220910.035
heart developmentGO:00075073130.035
regulation of cellular ketone metabolic processGO:001056570.035
carbon dioxide transportGO:001567030.035
generation of neuronsGO:00486993850.035
bmp signaling pathwayGO:0030509520.035
positive regulation of cellular amino acid metabolic processGO:004576400.034
immune system developmentGO:00025201910.034
gastrulationGO:00073692080.034
macromolecule modificationGO:00434121110.034
segmentationGO:0035282970.034
cellular response to organic substanceGO:00713101050.034
response to vitaminGO:003327330.033
epithelial tube morphogenesisGO:00605621480.033
negative regulation of mapk cascadeGO:004340940.033
regulation of cell activationGO:005086510.033
b cell activationGO:004211320.033
stem cell maintenanceGO:001982740.032
peptide transportGO:001583310.032
cell morphogenesis involved in neuron differentiationGO:00486671630.032
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.032
regulation of protein metabolic processGO:0051246560.032
Human Mouse
cellular response to endogenous stimulusGO:0071495680.032
growthGO:00400071740.031
regulation of tube sizeGO:003515020.031
negative regulation of signal transductionGO:0009968940.031
response to monosaccharideGO:003428430.031
ion homeostasisGO:0050801410.030
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.030
agingGO:000756820.030
connective tissue developmentGO:0061448990.030
sequestering of metal ionGO:005123830.030
development of primary female sexual characteristicsGO:004654540.030
negative regulation of map kinase activityGO:004340720.029
positive regulation of signal transductionGO:0009967560.029
response to drugGO:004249330.029
cellular amide metabolic processGO:004360340.029
blood vessel morphogenesisGO:00485142160.029
maintenance of locationGO:005123540.028
embryonic heart tube developmentGO:00350501330.028
response to carbohydrateGO:000974330.028
dicarboxylic acid transportGO:000683510.028
cation homeostasisGO:0055080330.027
neuron developmentGO:00486662620.027
determination of ventral identityGO:0048264210.027
negative regulation of kinase activityGO:003367340.027
phagocytosisGO:000690930.027
cell part morphogenesisGO:00329902460.027
anterior posterior pattern specificationGO:00099521520.026
calcium ion homeostasisGO:0055074190.026
gland developmentGO:00487321430.026
developmental growth involved in morphogenesisGO:0060560860.026
negative regulation of protein serine threonine kinase activityGO:007190120.026
cartilage developmentGO:0051216960.026
immune system processGO:00023762410.026
Human
regulation of axon extensionGO:0030516240.025
positive regulation of macromolecule metabolic processGO:0010604930.025
positive regulation of cell communicationGO:0010647560.025
female gonad developmentGO:000858540.025
single organism metabolic processGO:00447102170.025
Human
somitogenesisGO:0001756870.025
regulation of blood vessel sizeGO:005088020.025
regulation of cell morphogenesisGO:0022604420.025
regulation of multicellular organism growthGO:004001440.025
regulation of cell communicationGO:00106462320.024
cell deathGO:00082191210.024
metal ion homeostasisGO:0055065260.024
protein modification processGO:00362111000.024
protein metabolic processGO:00195381830.024
Human Mouse
protein localization to plasma membraneGO:007265910.024
somatic stem cell maintenanceGO:003501910.024
cell growthGO:0016049570.024
neuron projection extensionGO:1990138450.024
negative regulation of sequestering of calcium ionGO:005128340.024
neuron projection developmentGO:00311751800.024
intestinal absorptionGO:005089220.024
cell projection morphogenesisGO:00488582440.023
positive regulation of catabolic processGO:000989640.023
cytosolic calcium ion transportGO:006040130.023
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.023
determination of dorsal ventral asymmetryGO:0048262340.023
regulation of signalingGO:00230512350.023
regulation of cell developmentGO:00602841000.023
hemopoiesisGO:00300971830.023
regulation of cellular component movementGO:0051270550.023
positive regulation of nucleobase containing compound metabolic processGO:0045935690.022
regulation of i kappab kinase nf kappab signalingGO:004312240.022
response to hexoseGO:000974630.022
positive regulation of epithelial cell differentiationGO:003085820.022
cation transmembrane transportGO:0098655650.022
cellular protein metabolic processGO:00442671290.022
Human Mouse
embryonic organ morphogenesisGO:00485622740.022
positive regulation of gene expressionGO:0010628710.022
regulation of synaptic growth at neuromuscular junctionGO:000858210.022
positive regulation of translationGO:004572710.022
energy reserve metabolic processGO:000611220.022
positive regulation of cellular metabolic processGO:0031325940.022
wound healingGO:0042060900.022
behaviorGO:0007610740.022
positive regulation of stress activated mapk cascadeGO:003287430.022
phosphorus metabolic processGO:00067931090.021
cellular response to xenobiotic stimulusGO:0071466350.021
lateral inhibitionGO:004633110.021
homeostatic processGO:00425921420.021
response to ketoneGO:190165410.021
blood vessel developmentGO:00015682460.021
regulation of blood pressureGO:000821710.021
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.021
cellular amino acid metabolic processGO:000652070.021
regulation of cell differentiationGO:00455951420.021
regulation of neurogenesisGO:0050767870.021
axonogenesisGO:00074091520.021
calcium ion transport into cytosolGO:006040230.021
positive regulation of biosynthetic processGO:0009891680.021
blood circulationGO:0008015870.021
fin developmentGO:0033333770.021
organelle organizationGO:00069962270.021
establishment of protein localization to plasma membraneGO:009000210.021
establishment of organelle localizationGO:0051656450.020
negative regulation of jnk cascadeGO:004632910.020
regulation of glial cell differentiationGO:004568540.020
cellular ketone metabolic processGO:0042180110.020
cellular component biogenesisGO:00440851780.020
positive regulation of metabolic processGO:00098931080.020
developmental growthGO:00485891660.020
one carbon compound transportGO:0019755140.020
heart morphogenesisGO:00030071560.020
response to abiotic stimulusGO:00096281220.020
regulation of cell morphogenesis involved in differentiationGO:0010769380.020
positive regulation of cytokine productionGO:000181920.020
response to estrogenGO:0043627270.020
regulation of extent of cell growthGO:0061387290.020
positive regulation of cell activationGO:005086710.019
spindle localizationGO:0051653120.019
enzyme linked receptor protein signaling pathwayGO:00071671060.019
circulatory system processGO:0003013870.019
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.019
determination of left right symmetryGO:00073681790.019
response to osmotic stressGO:0006970110.019
regulation of cell deathGO:00109411030.019
cellular protein catabolic processGO:004425740.019
positive regulation of nucleic acid templated transcriptionGO:1903508570.019
regulation of systemic arterial blood pressureGO:000307310.019
regulation of endocrine processGO:004406020.019
cortical actin cytoskeleton organizationGO:003086610.019
response to hydrogen peroxideGO:004254230.019
regulation of cellular carbohydrate metabolic processGO:001067540.019
single organismal cell cell adhesionGO:0016337290.018
negative regulation of signalingGO:0023057960.018
nuclear migrationGO:000709730.018
response to endogenous stimulusGO:0009719830.018
myeloid cell differentiationGO:0030099860.018
guanosine containing compound metabolic processGO:190106840.018
regulation of jak stat cascadeGO:004642530.018
multi organism processGO:00517041340.018
Mouse
positive regulation of endothelial cell proliferationGO:000193810.018
positive regulation of i kappab kinase nf kappab signalingGO:004312330.018
regulation of bone remodelingGO:004685020.018
negative regulation of cell communicationGO:0010648960.018
phosphate containing compound metabolic processGO:00067961080.018
negative regulation of leukocyte differentiationGO:190210610.018
tissue regenerationGO:0042246740.018
positive regulation of cell adhesionGO:004578510.018
insulin like growth factor receptor signaling pathwayGO:004800940.018
regulation of carbohydrate metabolic processGO:000610940.018
deathGO:00162651210.018
tube closureGO:006060610.017
regulation of bmp signaling pathwayGO:0030510390.017
apoptotic processGO:00069151160.017
negative regulation of cellular metabolic processGO:0031324770.017
Human Mouse
mitochondrion organizationGO:000700540.017
g protein coupled receptor signaling pathwayGO:0007186740.017
pancreas developmentGO:0031016840.017
hormone secretionGO:004687920.017
regulation of anatomical structure morphogenesisGO:00226031300.017
regulation of reactive oxygen species metabolic processGO:200037720.017
cellular response to lipopolysaccharideGO:007122230.017
inner ear developmentGO:00488391260.017
cardiac atrium developmentGO:000323040.017
cellular carbohydrate metabolic processGO:004426240.016
phagocytosis engulfmentGO:000691110.016
organelle fusionGO:004828430.016
inorganic cation transmembrane transportGO:0098662500.016
regulation of cytoplasmic transportGO:190364940.016
release of sequestered calcium ion into cytosolGO:005120930.016
organonitrogen compound metabolic processGO:1901564740.016
protein localization to nucleusGO:003450430.016
apoptotic signaling pathwayGO:0097190230.016
keratinocyte differentiationGO:003021600.016
response to inorganic substanceGO:0010035380.016
cognitionGO:005089010.016
epithelial cell differentiationGO:00308551160.016
negative regulation of defense responseGO:003134820.016
Human
developmental programmed cell deathGO:001062340.016
endoderm developmentGO:0007492490.016
spermatid developmentGO:000728620.016
cellular response to lipidGO:0071396390.016
cellular response to hypoxiaGO:007145610.016
response to starvationGO:004259450.016
negative regulation of cytokine productionGO:000181810.015
regulation of cell projection organizationGO:0031344440.015
synaptic vesicle transportGO:004848910.015
regenerationGO:0031099910.015
positive regulation of immune effector processGO:000269930.015
cellular modified amino acid metabolic processGO:000657530.015
regulation of establishment of planar polarityGO:009017540.015
axon guidanceGO:0007411860.015
positive regulation of secretion by cellGO:190353210.015
single organism cell adhesionGO:0098602290.015
cellular component assemblyGO:00226071700.015
regulation of production of molecular mediator of immune responseGO:000270010.015
regulation of myeloid cell differentiationGO:004563780.015
gtp catabolic processGO:000618420.015
regulation of transmembrane transporter activityGO:002289820.015
mesenchymal cell developmentGO:0014031780.015
meiotic nuclear divisionGO:000712640.015
negative regulation of macromolecule metabolic processGO:0010605760.015
Human Mouse
single organism organelle organizationGO:19025891990.015
positive regulation of jnk cascadeGO:004633030.015
eye developmentGO:00016542770.015
regulation of membrane potentialGO:0042391230.015
secondary metabolic processGO:001974830.015
actin filament based movementGO:003004810.015
i kappab kinase nf kappab signalingGO:000724940.015
developmental cell growthGO:0048588520.015
stem cell proliferationGO:007208940.015
regulation of protein complex assemblyGO:004325430.015
regulation of locomotionGO:0040012550.015
regulation of protein transportGO:005122330.015
positive regulation of secretionGO:005104710.015
ear developmentGO:00435831270.015
leukocyte proliferationGO:007066110.015
autophagyGO:000691440.015
positive regulation of nitrogen compound metabolic processGO:0051173690.015
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.015
regulation of cell shapeGO:000836010.015
wnt signaling pathway planar cell polarity pathwayGO:006007140.015
organism emergence from protective structureGO:007168440.015
positive regulation of rna metabolic processGO:0051254590.015
cellular protein modification processGO:00064641000.014
divalent inorganic cation homeostasisGO:0072507220.014
interspecies interaction between organismsGO:004441940.014
regulation of dendrite developmentGO:005077330.014
notochord developmentGO:0030903540.014
cellular response to organic cyclic compoundGO:0071407380.014
adult behaviorGO:003053420.014
dorsal convergenceGO:0060030140.014
cellular homeostasisGO:0019725260.014
gtp metabolic processGO:004603940.014
sensory perception of chemical stimulusGO:000760630.014
mesenchyme developmentGO:00604851270.014
b cell differentiationGO:003018310.014
divalent inorganic cation transportGO:0072511210.014
regulation of reproductive processGO:200024140.014
regulation of calcium ion transportGO:005192420.014
adherens junction maintenanceGO:003433420.014
negative regulation of metabolic processGO:0009892860.014
Human Mouse
cellular component maintenanceGO:004395430.014
regulation of catalytic activityGO:0050790550.014
Human Mouse
spermatid differentiationGO:004851520.014
regulation of lipid transportGO:003236840.014
positive regulation of leukocyte differentiationGO:190210710.014
regulation of purine nucleotide catabolic processGO:003312120.014
cellular localizationGO:0051641970.014
signal transduction in absence of ligandGO:003803410.014
sodium ion importGO:009736930.014
endodermal cell fate determinationGO:000749320.014
positive regulation of cellular amine metabolic processGO:003324000.014
actin polymerization or depolymerizationGO:000815420.014
bicarbonate transportGO:001570140.014
regulation of cellular phGO:003064110.014
protein dephosphorylationGO:000647030.014
organic substance transportGO:0071702580.014
hematopoietic or lymphoid organ developmentGO:00485341910.013
axon extensionGO:0048675450.013
cytokinesisGO:000091030.013
single organism nuclear importGO:190259330.013
protein targeting to nucleusGO:004474430.013
regulation of bindingGO:005109830.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.013
regulation of leukocyte mediated immunityGO:000270310.013
guanosine containing compound catabolic processGO:190106920.013
regulation of protein polymerizationGO:003227120.013
proteasomal protein catabolic processGO:001049820.013
response to xenobiotic stimulusGO:0009410450.013
nuclear importGO:005117030.013
positive regulation of inflammatory responseGO:005072910.013
regulation of erythrocyte differentiationGO:004564620.013
response to fluid shear stressGO:003440520.013
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.013
exocytosisGO:000688710.013
cellular response to stressGO:0033554620.013
hypotonic responseGO:000697150.013
embryonic skeletal system developmentGO:0048706970.013
regulation of cell adhesionGO:0030155150.013
regulation of dna templated transcription in response to stressGO:004362000.013
negative regulation of biosynthetic processGO:0009890550.013
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.013
response to uvGO:000941130.013
amino acid transportGO:000686520.013
determination of heart left right asymmetryGO:00613711170.013
phosphorylationGO:0016310690.013
synaptic transmission cholinergicGO:000727140.013
positive regulation of cell cycleGO:004578730.013
membrane invaginationGO:001032410.013
positive regulation of leukocyte mediated immunityGO:000270510.013
carbohydrate homeostasisGO:003350010.013
sodium ion transmembrane transportGO:0035725210.013
regulation of programmed cell deathGO:00430671010.013
positive regulation of cellular biosynthetic processGO:0031328680.013
septum transversum developmentGO:000334340.012
nucleocytoplasmic transportGO:000691340.012
protein acetylationGO:000647320.012
multicellular organismal metabolic processGO:004423620.012
negative regulation of stem cell differentiationGO:200073720.012
chemical homeostasisGO:0048878490.012
response to foodGO:003209410.012
cell proliferationGO:0008283800.012
regulation of cell growthGO:0001558290.012
actin filament polymerizationGO:003004120.012
skeletal system morphogenesisGO:00487051020.012
positive regulation of apoptotic signaling pathwayGO:200123510.012
vasculature developmentGO:00019442780.012
rna localizationGO:000640340.012
neuroblast proliferationGO:000740520.012
positive regulation of lymphocyte mediated immunityGO:000270810.012

a2ml disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.141
Human
nervous system diseaseDOID:86300.038
Human
musculoskeletal system diseaseDOID:1700.024
sensory system diseaseDOID:005015500.023
eye and adnexa diseaseDOID:149200.023
eye diseaseDOID:561400.023
cardiovascular system diseaseDOID:128700.022
connective tissue diseaseDOID:6500.019
bone diseaseDOID:008000100.019
inherited metabolic disorderDOID:65500.018
disease of metabolismDOID:001466700.018
retinal diseaseDOID:567900.014
retinal degenerationDOID:846600.014
retinitis pigmentosaDOID:1058400.014