Danio rerio

66 known processes

pak1

p21/Cdc42/Rac1-activated kinase 1

(Aliases: cb761,wu:fj97h10)

pak1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
single organism organelle organizationGO:19025891990.758
cytoskeleton organizationGO:0007010960.745
cellular component morphogenesisGO:00329893360.688
digestive system developmentGO:00551232890.678
cell projection assemblyGO:0030031640.667
actin cytoskeleton organizationGO:0030036630.653
actin filament based processGO:0030029640.632
cellular component assemblyGO:00226071700.574
organelle assemblyGO:00709251100.546
negative regulation of cellular processGO:00485232830.534
cellular component biogenesisGO:00440851780.492
regulation of cell projection assemblyGO:006049140.424
negative regulation of biological processGO:00485193040.415
locomotionGO:00400113130.364
cell morphogenesisGO:00009022890.353
regulation of cell shapeGO:000836010.343
negative regulation of canonical wnt signaling pathwayGO:0090090210.336
cilium organizationGO:0044782710.334
embryonic organ developmentGO:00485683810.320
regulation of circadian rhythmGO:004275240.307
phosphate containing compound metabolic processGO:00067961080.290
mitotic cell cycle processGO:1903047480.279
sensory organ developmentGO:00074233930.273
regulation of cellular metabolic processGO:00313233200.270
cell morphogenesis involved in differentiationGO:00009041950.238
cellular protein metabolic processGO:00442671290.234
kupffer s vesicle developmentGO:0070121500.225
organelle organizationGO:00069962270.202
regulation of nucleocytoplasmic transportGO:004682220.201
ameboidal type cell migrationGO:00016671430.195
cell surface receptor signaling pathwayGO:00071663250.192
digestive tract morphogenesisGO:00485462310.190
cell projection morphogenesisGO:00488582440.189
pronephros developmentGO:0048793690.187
cell matrix adhesionGO:000716040.181
pigmentationGO:0043473850.180
nucleocytoplasmic transportGO:000691340.174
cell projection organizationGO:00300302840.173
central nervous system developmentGO:00074173870.170
tor signalingGO:003192970.167
macromolecule modificationGO:00434121110.167
regulation of primary metabolic processGO:00800903110.166
regulation of synapse organizationGO:005080730.162
mitotic cell cycleGO:0000278640.159
convergent extensionGO:00600261180.158
cell part morphogenesisGO:00329902460.156
cellular localizationGO:0051641970.154
cellular protein modification processGO:00064641000.154
regulation of cytoplasmic transportGO:190364940.151
radial glial cell differentiationGO:006001920.147
axon developmentGO:00615641660.143
neuron differentiationGO:00301823530.143
organonitrogen compound metabolic processGO:1901564740.142
hematopoietic or lymphoid organ developmentGO:00485341910.139
protein dephosphorylationGO:000647030.139
regulation of protein localization to nucleusGO:190018020.138
cyclic nucleotide metabolic processGO:0009187180.137
determination of heart left right asymmetryGO:00613711170.136
microtubule based processGO:0007017600.130
negative regulation of cell communicationGO:0010648960.129
regulation of localizationGO:00328791040.125
digestive tract developmentGO:00485652650.124
cytokinesisGO:000091030.122
positive regulation of macromolecule metabolic processGO:0010604930.122
positive regulation of cell communicationGO:0010647560.113
protein targeting to nucleusGO:004474430.113
single organism intracellular transportGO:1902582250.111
nucleic acid transportGO:005065720.110
nuclear transportGO:005116940.110
protein modification processGO:00362111000.109
macromolecular complex subunit organizationGO:0043933740.107
growthGO:00400071740.106
response to abiotic stimulusGO:00096281220.104
larval developmentGO:000216420.103
gastrulationGO:00073692080.102
notch signaling pathwayGO:0007219350.101
single organism nuclear importGO:190259330.100
regulation of protein modification by small protein conjugation or removalGO:190332030.099
startle responseGO:000196440.097
nuclear importGO:005117030.096
regulation of catalytic activityGO:0050790550.095
immune system processGO:00023762410.095
regulation of protein transportGO:005122330.093
regulation of protein import into nucleusGO:004230620.093
regulation of intracellular protein transportGO:003315730.091
regulation of metabolic processGO:00192223590.091
cell morphogenesis involved in neuron differentiationGO:00486671630.090
cilium assemblyGO:0042384580.089
response to external stimulusGO:00096052640.089
regulation of cell morphogenesisGO:0022604420.086
positive regulation of transportGO:005105020.085
regulation of filopodium assemblyGO:005148920.084
cellular component movementGO:00069283350.084
protein n linked glycosylationGO:000648710.082
cell cycle processGO:0022402530.081
developmental growthGO:00485891660.080
regulation of apoptotic processGO:0042981980.079
generation of neuronsGO:00486993850.078
cell cycleGO:0007049930.078
positive regulation of map kinase activityGO:004340630.078
regulation of nucleic acid templated transcriptionGO:19035062130.077
multicellular organism growthGO:003526440.075
response to stressGO:00069502630.074
protein localization to nucleusGO:003450430.074
cell migrationGO:00164772370.074
wnt signaling pathwayGO:0016055800.073
negative regulation of apoptotic processGO:0043066550.073
protein polymerizationGO:005125840.072
small molecule metabolic processGO:0044281770.071
camera type eye developmentGO:00430102220.071
regulation of anatomical structure morphogenesisGO:00226031300.071
regulation of collateral sprouting in absence of injuryGO:004869640.067
amine metabolic processGO:000930820.065
synaptic growth at neuromuscular junctionGO:005112420.064
immune system developmentGO:00025201910.064
peripheral nervous system neuron differentiationGO:0048934280.064
peptidyl serine modificationGO:001820920.062
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.061
positive regulation of protein metabolic processGO:0051247230.060
regulation of wnt signaling pathwayGO:0030111530.060
protein metabolic processGO:00195381830.059
dorsal ventral pattern formationGO:00099531250.059
regulation of cellular component organizationGO:0051128860.058
positive regulation of cell cycleGO:004578730.058
filopodium assemblyGO:004684750.056
single organism cellular localizationGO:1902580460.055
neuron projection developmentGO:00311751800.055
eye developmentGO:00016542770.055
apoptotic processGO:00069151160.055
microtubule cytoskeleton organizationGO:0000226330.055
sensory system developmentGO:0048880760.054
establishment of mitotic spindle localizationGO:0040001120.054
regulation of establishment of protein localizationGO:007020140.054
positive regulation of catabolic processGO:000989640.054
phosphorus metabolic processGO:00067931090.054
regulation of multicellular organism growthGO:004001440.054
regulation of synapse assemblyGO:005196330.054
regulation of biological qualityGO:00650082630.053
positive regulation of cellular component biogenesisGO:004408930.052
hemopoiesisGO:00300971830.050
regulation of multicellular organismal processGO:00512392770.050
actin filament organizationGO:0007015150.049
regulation of cell morphogenesis involved in differentiationGO:0010769380.049
programmed cell deathGO:00125011190.048
signal transductionGO:00071654550.047
protein import into nucleusGO:000660630.047
establishment of protein localization to organelleGO:007259440.046
sensory organ morphogenesisGO:00905962000.046
cytoplasmic transportGO:0016482110.046
regulation of striated muscle contractionGO:000694220.046
inner ear developmentGO:00488391260.046
neuron migrationGO:0001764220.045
morphogenesis of an epitheliumGO:00020093330.044
system processGO:00030081850.044
positive regulation of cellular metabolic processGO:0031325940.044
single organism metabolic processGO:00447102170.043
peripheral nervous system neuron axonogenesisGO:0048936130.042
cellular response to extracellular stimulusGO:003166820.042
axonogenesisGO:00074091520.042
regulation of protein targetingGO:190353320.042
positive regulation of metabolic processGO:00098931080.042
positive regulation of oocyte developmentGO:006028210.041
brain developmentGO:00074202930.041
regenerationGO:0031099910.041
regulation of response to stimulusGO:00485832690.041
intracellular transportGO:0046907320.040
adult behaviorGO:003053420.040
positive regulation of cellular protein metabolic processGO:0032270220.040
negative regulation of cell migrationGO:0030336170.040
ventricular cardiac muscle tissue morphogenesisGO:005501020.040
maintenance of locationGO:005123540.039
neurological system processGO:0050877620.038
positive regulation of cellular amino acid metabolic processGO:004576400.038
regulation of programmed cell deathGO:00430671010.038
cellular component assembly involved in morphogenesisGO:00109271070.038
lipid storageGO:001991510.037
single organism transportGO:00447652060.037
heart developmentGO:00075073130.037
establishment of localization in cellGO:0051649770.037
agingGO:000756820.036
neuromast developmentGO:0048884460.035
sensory perceptionGO:0007600390.035
extrinsic apoptotic signaling pathwayGO:009719130.035
calcium ion transmembrane transportGO:0070588130.035
positive regulation of cell deathGO:0010942290.035
cell cycle phase transitionGO:004477090.034
hepaticobiliary system developmentGO:0061008980.034
regionalizationGO:00030022740.033
head developmentGO:00603223030.033
cell cycle g1 s phase transitionGO:004484310.033
establishment of spindle orientationGO:0051294100.032
striated muscle cell developmentGO:00550021080.032
negative regulation of response to stimulusGO:00485851040.032
protein importGO:001703830.032
compound eye developmentGO:004874920.032
regulation of metal ion transportGO:001095940.031
regulation of nucleobase containing compound metabolic processGO:00192192500.031
cell cycle g2 m phase transitionGO:004483940.031
mitotic cell cycle phase transitionGO:004477290.031
tissue migrationGO:0090130370.031
response to metal ionGO:0010038340.030
cell substrate adhesionGO:003158940.030
fin developmentGO:0033333770.030
cell migration involved in gastrulationGO:0042074790.030
renal system developmentGO:0072001940.030
cell motilityGO:00488702440.029
negative regulation of dna metabolic processGO:005105340.029
regulation of cytoskeleton organizationGO:0051493110.029
specification of symmetryGO:00097992040.029
embryonic organ morphogenesisGO:00485622740.029
cellular protein catabolic processGO:004425740.029
regulation of cellular amine metabolic processGO:003323800.028
regulation of developmental growthGO:0048638380.028
tube morphogenesisGO:00352393490.028
protein complex disassemblyGO:004324110.028
wound healingGO:0042060900.027
intracellular signal transductionGO:0035556850.027
neuron projection regenerationGO:0031102160.027
positive regulation of signalingGO:0023056560.027
regulation of multicellular organismal developmentGO:20000262230.027
regulation of calcium ion transportGO:005192420.027
activation of mapk activityGO:000018730.026
developmental growth involved in morphogenesisGO:0060560860.026
regulation of kinase activityGO:0043549150.026
epithelial cell migrationGO:0010631250.026
peptidyl serine phosphorylationGO:001810510.026
kidney developmentGO:0001822920.025
positive regulation of signal transductionGO:0009967560.025
regulation of cell communicationGO:00106462320.024
ventricular cardiac muscle tissue developmentGO:000322930.024
inner ear morphogenesisGO:0042472630.024
epithelial tube morphogenesisGO:00605621480.024
protein complex biogenesisGO:0070271300.024
g1 s transition of mitotic cell cycleGO:000008210.024
positive regulation of apoptotic signaling pathwayGO:200123510.024
neuron projection morphogenesisGO:00488121610.024
regulation of growthGO:0040008420.023
regulation of molecular functionGO:0065009700.023
regulation of cellular ketone metabolic processGO:001056570.023
establishment of spindle localizationGO:0051293120.023
response to starvationGO:004259450.023
regulation of mitosisGO:000708890.023
somatic stem cell maintenanceGO:003501910.022
ph reductionGO:004585110.022
regulation of cell deathGO:00109411030.022
establishment of localizationGO:00512342440.022
regulation of signalingGO:00230512350.021
positive regulation of cellular amine metabolic processGO:003324000.021
regulation of microtubule cytoskeleton organizationGO:007050730.021
cilium morphogenesisGO:0060271850.021
urogenital system developmentGO:0001655970.021
convergent extension involved in gastrulationGO:0060027710.021
cell substrate junction assemblyGO:000704420.021
biological adhesionGO:0022610400.021
gtp catabolic processGO:000618420.021
peripheral nervous system neuron developmentGO:0048935220.021
cellular component disassemblyGO:002241110.021
determination of bilateral symmetryGO:00098552040.021
mesenchymal cell developmentGO:0014031780.021
regulation of protein ubiquitinationGO:003139630.021
regulation of neuron differentiationGO:0045664560.020
phagocytosis engulfmentGO:000691110.020
protein complex assemblyGO:0006461300.020
response to woundingGO:00096111160.020
regulation of transmembrane transporter activityGO:002289820.020
regulation of cell matrix adhesionGO:000195210.020
phosphorylationGO:0016310690.020
regulation of cell projection organizationGO:0031344440.020
regulation of phosphate metabolic processGO:0019220430.019
positive regulation of embryonic developmentGO:004001930.019
regulation of developmental processGO:00507932470.019
cell cell recognitionGO:000998810.019
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.019
epithelial cell morphogenesisGO:000338220.019
regulation of dna replicationGO:000627530.019
neuromast depositionGO:004888590.019
cellular protein complex assemblyGO:0043623190.019
single organism localizationGO:19025782250.018
g2 m transition of mitotic cell cycleGO:000008640.018
body morphogenesisGO:0010171160.018
negative regulation of wnt signaling pathwayGO:0030178300.018
mitotic nuclear divisionGO:0007067180.018
negative regulation of signal transductionGO:0009968940.018
deathGO:00162651210.018
regulation of cell cycleGO:0051726520.018
negative regulation of kinase activityGO:003367340.017
negative regulation of signalingGO:0023057960.017
positive regulation of cell proliferationGO:0008284150.017
microtubule depolymerizationGO:000701910.017
protein phosphorylationGO:0006468470.017
regulation of synaptic growth at neuromuscular junctionGO:000858210.017
regulation of anatomical structure sizeGO:0090066330.017
cation transmembrane transportGO:0098655650.017
developmental cell growthGO:0048588520.017
regulation of tor signalingGO:003200670.017
epidermal cell differentiationGO:0009913360.017
muscle cell fate determinationGO:000752110.017
ganglioside metabolic processGO:000157330.017
posterior lateral line neuromast developmentGO:0048919200.016
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.016
positive regulation of jak stat cascadeGO:004642720.016
glial cell proliferationGO:001400940.016
positive regulation of cellular processGO:00485222010.016
macromolecular complex disassemblyGO:003298410.016
embryonic heart tube developmentGO:00350501330.016
skin developmentGO:0043588540.016
embryonic skeletal system morphogenesisGO:0048704930.016
regulation of oligodendrocyte differentiationGO:004871310.016
regulation of protein phosphorylationGO:0001932180.016
negative regulation of molecular functionGO:0044092230.016
ion transmembrane transportGO:0034220910.016
cell deathGO:00082191210.015
regulation of cell migrationGO:0030334400.015
regulation of organelle organizationGO:0033043290.015
glycosylationGO:0070085110.015
positive regulation of catalytic activityGO:0043085250.015
protein localizationGO:0008104400.015
calcium ion dependent exocytosisGO:001715610.015
negative regulation of cellular component movementGO:0051271180.015
protein complex subunit organizationGO:0071822460.015
regulation of cell activationGO:005086510.015
stem cell maintenanceGO:001982740.015
regulation of epithelial cell proliferationGO:005067830.015
ectodermal cell differentiationGO:001066820.015
nuclear divisionGO:0000280230.015
establishment of cell polarityGO:0030010180.015
regulation of cell differentiationGO:00455951420.015
actomyosin structure organizationGO:0031032530.015
mesenchymal cell differentiationGO:0048762870.015
regulation of protein depolymerizationGO:190187910.014
endothelial cell migrationGO:0043542190.014
positive regulation of exocytosisGO:004592110.014
transportGO:00068102200.014
neural crest cell developmentGO:0014032620.014
organ regenerationGO:003110010.014
microtubule polymerization or depolymerizationGO:003110930.014
macromolecule biosynthetic processGO:00090592270.014
rhythmic processGO:0048511210.014
myofibril assemblyGO:0030239480.014
positive regulation of biological processGO:00485182530.014
regulation of nucleotide catabolic processGO:003081120.014
transcription dna templatedGO:00063511810.014
cellular ketone metabolic processGO:0042180110.014
stem cell proliferationGO:007208940.014
inorganic ion transmembrane transportGO:0098660570.013
regulation of glial cell differentiationGO:004568540.013
regulation of cell cycle processGO:0010564200.013
regulation of jak stat cascadeGO:004642530.013
stem cell differentiationGO:00488631170.013
regulation of protein catabolic processGO:004217610.013
cell substrate adherens junction assemblyGO:000704510.013
taxisGO:00423301090.013
positive regulation of biosynthetic processGO:0009891680.013
posterior lateral line system developmentGO:0048915460.013
macromolecular complex assemblyGO:0065003350.013
cellular nitrogen compound metabolic processGO:00346412900.013
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.013
positive regulation of apoptotic processGO:0043065290.013
proteasomal protein catabolic processGO:001049820.013
negative regulation of protein complex assemblyGO:003133310.013
inorganic cation transmembrane transportGO:0098662500.013
regulation of gtp catabolic processGO:003312420.013
carbohydrate derivative metabolic processGO:1901135610.013
cognitionGO:005089010.013
response to corticosteroidGO:003196010.012
amino acid transportGO:000686520.012
cellular amine metabolic processGO:004410620.012
regulation of ectodermal cell fate specificationGO:004266520.012
cell proliferationGO:0008283800.012
biosynthetic processGO:00090582940.012
divalent inorganic cation transportGO:0072511210.012
kidney morphogenesisGO:0060993150.012
vasculature developmentGO:00019442780.012
negative regulation of multi organism processGO:004390130.012
developmental process involved in reproductionGO:0003006270.012
ectodermal cell fate specificationGO:000171520.012
mechanoreceptor differentiationGO:0042490370.012
signal transduction in absence of ligandGO:003803410.012
embryonic heart tube morphogenesisGO:00031431080.012
regulation of nitrogen compound metabolic processGO:00511712510.012
cellular amino acid metabolic processGO:000652070.012
regulation of protein complex assemblyGO:004325430.012
ear developmentGO:00435831270.012
negative regulation of cell motilityGO:2000146170.011
myeloid leukocyte differentiationGO:0002573150.011
regulation of muscle contractionGO:000693730.011
regulation of cell adhesionGO:0030155150.011
gland developmentGO:00487321430.011
regulation of calcium ion dependent exocytosisGO:001715810.011
olfactory placode morphogenesisGO:007169970.011
head morphogenesisGO:006032380.011
actin polymerization or depolymerizationGO:000815420.011
actin filament polymerizationGO:003004120.011
positive regulation of cellular catabolic processGO:003133130.011
regulation of ectoderm developmentGO:200038320.011
positive regulation of programmed cell deathGO:0043068290.011
positive regulation of phosphate metabolic processGO:0045937210.011
negative regulation of notch signaling pathwayGO:004574660.011
regulation of transferase activityGO:0051338160.011
canonical wnt signaling pathwayGO:0060070480.011
regulation of reproductive processGO:200024140.011
modification dependent protein catabolic processGO:001994130.011
neuroblast proliferationGO:000740520.011
establishment of organelle localizationGO:0051656450.011
negative regulation of protein kinase activityGO:000646940.011
regulation of cellular phGO:003064110.011
regulation of protein metabolic processGO:0051246560.011
regulation of peptidyl tyrosine phosphorylationGO:005073010.010
regulation of receptor mediated endocytosisGO:004825940.010
regulation of establishment of planar polarityGO:009017540.010
renal tubule morphogenesisGO:006133310.010
response to decreased oxygen levelsGO:0036293250.010
cellular monovalent inorganic cation homeostasisGO:003000420.010
regulation of cellular component movementGO:0051270550.010
positive regulation of response to stimulusGO:0048584800.010
cellular macromolecule metabolic processGO:00442603910.010
negative regulation of locomotionGO:0040013180.010
negative regulation of intracellular transportGO:003238730.010
positive regulation of phosphorus metabolic processGO:0010562210.010

pak1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.033
organ system cancerDOID:005068600.033
cancerDOID:16200.033
disease of cellular proliferationDOID:1456600.033
nervous system diseaseDOID:86300.029
auditory system diseaseDOID:274200.023
autosomal dominant nonsyndromic deafnessDOID:005056400.023
nonsyndromic deafnessDOID:005056300.023
sensory system diseaseDOID:005015500.023
gastrointestinal system cancerDOID:311900.017
reproductive organ cancerDOID:19300.014