Danio rerio

56 known processes

slc11a2

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

(Aliases: MGC136699,wu:fa07b10,DMT1,cb426,zgc:136699,fa07b10)

slc11a2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular biosynthetic processGO:00442492860.540
aromatic compound biosynthetic processGO:00194382170.420
ion transportGO:00068111140.420
cellular nitrogen compound biosynthetic processGO:00442712180.385
regulation of metabolic processGO:00192223590.324
transmembrane transportGO:00550851200.321
regulation of cellular macromolecule biosynthetic processGO:20001122220.304
larval developmentGO:000216420.279
cellular transition metal ion homeostasisGO:004691630.273
organic substance biosynthetic processGO:19015762890.262
establishment of localizationGO:00512342440.245
cofactor biosynthetic processGO:0051188100.228
macromolecule biosynthetic processGO:00090592270.217
immune system processGO:00023762410.214
cellular aromatic compound metabolic processGO:00067252950.213
iron ion homeostasisGO:005507240.208
organic cyclic compound biosynthetic processGO:19013622230.193
nucleobase containing compound metabolic processGO:00061392740.193
transcription dna templatedGO:00063511810.192
transition metal ion homeostasisGO:005507650.188
biosynthetic processGO:00090582940.187
single organism transportGO:00447652060.183
cellular nitrogen compound metabolic processGO:00346412900.182
negative regulation of cellular processGO:00485232830.181
regulation of rna biosynthetic processGO:20011412130.177
porphyrin containing compound metabolic processGO:0006778100.174
nitrogen compound metabolic processGO:00068073190.169
regulation of cellular metabolic processGO:00313233200.166
organic cyclic compound metabolic processGO:19013603010.156
single organism localizationGO:19025782250.155
transition metal ion transportGO:000004160.145
hemopoiesisGO:00300971830.141
response to stressGO:00069502630.140
heterocycle metabolic processGO:00464832900.137
agingGO:000756820.132
hematopoietic or lymphoid organ developmentGO:00485341910.130
nucleobase containing compound biosynthetic processGO:00346542050.117
erythrocyte homeostasisGO:0034101550.117
regulation of transcription dna templatedGO:00063552130.117
generation of neuronsGO:00486993850.116
apoptotic processGO:00069151160.115
erythrocyte differentiationGO:0030218540.113
embryo development ending in birth or egg hatchingGO:00097922710.111
cellular macromolecule metabolic processGO:00442603910.110
response to inorganic substanceGO:0010035380.108
response to transition metal nanoparticleGO:1990267280.108
regulation of nucleic acid templated transcriptionGO:19035062130.106
positive regulation of biological processGO:00485182530.104
heterocycle biosynthetic processGO:00181302150.102
cation transportGO:0006812810.097
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.097
cellular macromolecule biosynthetic processGO:00346452240.095
regulation of transcription from rna polymerase ii promoterGO:00063571140.093
regulation of biological qualityGO:00650082630.092
embryonic organ developmentGO:00485683810.091
oxoacid metabolic processGO:0043436310.088
regulation of fatty acid metabolic processGO:001921710.088
transcription from rna polymerase ii promoterGO:0006366800.084
ion transmembrane transportGO:0034220910.084
meiotic nuclear divisionGO:000712640.083
establishment of protein localization to organelleGO:007259440.082
nucleic acid metabolic processGO:00903042440.081
transportGO:00068102200.081
regulation of macromolecule biosynthetic processGO:00105562250.081
hemoglobin biosynthetic processGO:004254180.080
gene expressionGO:00104672520.075
regulation of multicellular organism growthGO:004001440.074
rna biosynthetic processGO:00327741810.074
synaptic growth at neuromuscular junctionGO:005112420.073
response to abiotic stimulusGO:00096281220.072
heme metabolic processGO:004216890.071
anion transportGO:0006820380.071
regulation of cellular biosynthetic processGO:00313262450.070
immune system developmentGO:00025201910.070
lipid oxidationGO:003444010.068
regulation of primary metabolic processGO:00800903110.068
carbohydrate derivative metabolic processGO:1901135610.067
regulation of signal transductionGO:00099662250.064
regulation of dna templated transcription in response to stressGO:004362000.062
metal ion homeostasisGO:0055065260.062
negative regulation of biological processGO:00485193040.062
carboxylic acid metabolic processGO:0019752220.061
positive regulation of cellular catabolic processGO:003133130.060
maintenance of locationGO:005123540.060
establishment of localization in cellGO:0051649770.059
fatty acid beta oxidationGO:000663510.059
regulation of cell deathGO:00109411030.059
lipid storageGO:001991510.058
regulation of nitrogen compound metabolic processGO:00511712510.058
small molecule metabolic processGO:0044281770.057
guanosine containing compound metabolic processGO:190106840.057
regulation of biosynthetic processGO:00098892500.055
neuron differentiationGO:00301823530.055
regulation of protein ubiquitinationGO:003139630.053
cellular response to external stimulusGO:007149620.053
organonitrogen compound biosynthetic processGO:1901566470.053
chemical homeostasisGO:0048878490.052
single organism metabolic processGO:00447102170.051
cellular response to chemical stimulusGO:00708871570.050
mitochondrion organizationGO:000700540.050
regulation of translational initiationGO:000644610.048
proteolysis involved in cellular protein catabolic processGO:005160330.047
cell projection organizationGO:00300302840.047
myeloid cell differentiationGO:0030099860.047
rna metabolic processGO:00160702190.047
phagocytosisGO:000690930.047
cell part morphogenesisGO:00329902460.046
ion homeostasisGO:0050801410.046
vasculature developmentGO:00019442780.046
developmental growthGO:00485891660.046
regulation of wound healingGO:006104120.045
response to chemicalGO:00422213200.045
lipid catabolic processGO:001604240.045
amine metabolic processGO:000930820.044
positive regulation of catabolic processGO:000989640.043
negative regulation of kinase activityGO:003367340.042
regulation of cytokine productionGO:000181730.042
meiotic cell cycle processGO:190304630.041
endosomal transportGO:001619720.041
cell morphogenesis involved in differentiationGO:00009041950.041
regulation of nucleobase containing compound metabolic processGO:00192192500.040
microtubule organizing center organizationGO:003102310.040
organonitrogen compound metabolic processGO:1901564740.039
porphyrin containing compound biosynthetic processGO:000677980.039
organic acid metabolic processGO:0006082310.039
eye developmentGO:00016542770.039
regulation of gene expressionGO:00104682650.038
regulation of protein targetingGO:190353320.038
regulation of protein modification by small protein conjugation or removalGO:190332030.037
cellular amine metabolic processGO:004410620.037
cation homeostasisGO:0055080330.037
positive regulation of metabolic processGO:00098931080.036
gtp catabolic processGO:000618420.036
cell projection morphogenesisGO:00488582440.036
regulation of nucleoside metabolic processGO:000911820.036
cellular response to organic substanceGO:00713101050.035
negative regulation of protein phosphorylationGO:000193340.035
somatic muscle developmentGO:000752540.035
tissue remodelingGO:004877140.034
erythrocyte maturationGO:004324980.034
response to organic substanceGO:00100331530.034
negative regulation of protein kinase activityGO:000646940.034
dicarboxylic acid metabolic processGO:004364810.034
response to drugGO:004249330.034
growthGO:00400071740.034
axonogenesisGO:00074091520.033
metal ion transportGO:0030001580.033
nucleic acid templated transcriptionGO:00976591810.033
protein importGO:001703830.033
response to amino acidGO:004320020.033
meiotic chromosome segregationGO:004513230.033
cellular localizationGO:0051641970.033
spindle assemblyGO:005122520.032
neuron projection morphogenesisGO:00488121610.032
zymogen activationGO:003163830.032
ubiquitin dependent protein catabolic processGO:000651130.032
blood vessel morphogenesisGO:00485142160.031
response to unfolded proteinGO:000698620.031
inorganic ion transmembrane transportGO:0098660570.031
negative regulation of cell deathGO:0060548600.031
post embryonic organ developmentGO:004856940.031
regulation of cell shapeGO:000836010.031
regulation of apoptotic processGO:0042981980.031
cellular protein metabolic processGO:00442671290.031
iron ion transportGO:000682640.031
anion transmembrane transportGO:0098656120.031
cellular response to decreased oxygen levelsGO:003629410.030
mitochondrial transportGO:000683920.030
regulation of intracellular protein transportGO:003315730.030
regenerationGO:0031099910.030
cellular component disassemblyGO:002241110.030
regulation of macromolecule metabolic processGO:00602553170.030
neuron developmentGO:00486662620.029
gtp metabolic processGO:004603940.029
carbohydrate derivative biosynthetic processGO:1901137430.029
cellular lipid catabolic processGO:004424230.029
regulation of cell proliferationGO:0042127370.028
gland developmentGO:00487321430.028
regulation of i kappab kinase nf kappab signalingGO:004312240.028
signal transductionGO:00071654550.028
endoplasmic reticulum unfolded protein responseGO:003096820.028
homeostatic processGO:00425921420.028
response to external stimulusGO:00096052640.028
cell surface receptor signaling pathwayGO:00071663250.028
regulation of purine nucleotide catabolic processGO:003312120.027
pigment metabolic processGO:0042440120.027
multicellular organism growthGO:003526440.026
cytokinesisGO:000091030.026
response to nutrientGO:000758430.026
cation transmembrane transportGO:0098655650.026
transcription from rna polymerase iii promoterGO:000638310.026
system processGO:00030081850.026
i kappab kinase nf kappab signalingGO:000724940.026
response to topologically incorrect proteinGO:003596620.025
cellular iron ion homeostasisGO:000687930.025
tube morphogenesisGO:00352393490.025
regulation of epithelial cell proliferationGO:005067830.024
positive regulation of type i interferon productionGO:003248110.024
regulation of establishment of protein localizationGO:007020140.024
inorganic cation transmembrane transportGO:0098662500.024
protein localization to nucleusGO:003450430.024
myeloid cell homeostasisGO:0002262560.024
cellular ion homeostasisGO:0006873170.024
regulation of cellular amine metabolic processGO:003323800.024
fatty acid oxidationGO:001939510.024
protein metabolic processGO:00195381830.024
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.024
cell deathGO:00082191210.024
cellular component morphogenesisGO:00329893360.023
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.023
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.023
positive regulation of cellular metabolic processGO:0031325940.023
positive regulation of stress activated mapk cascadeGO:003287430.023
programmed cell deathGO:00125011190.023
enzyme linked receptor protein signaling pathwayGO:00071671060.023
cellular amino acid metabolic processGO:000652070.023
response to hydrogen peroxideGO:004254230.023
regulation of sodium ion transportGO:000202820.023
heart developmentGO:00075073130.023
axon developmentGO:00615641660.023
regulation of extrinsic apoptotic signaling pathwayGO:200123630.023
response to light stimulusGO:0009416460.023
regulation of programmed cell deathGO:00430671010.023
positive regulation of gtp catabolic processGO:003312610.022
positive regulation of nitrogen compound metabolic processGO:0051173690.022
positive regulation of wound healingGO:009030310.022
phagocytosis engulfmentGO:000691110.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.021
regulation of response to stimulusGO:00485832690.021
type i interferon productionGO:003260620.021
tetrapyrrole biosynthetic processGO:003301480.021
amino acid transportGO:000686520.021
positive regulation of purine nucleotide catabolic processGO:003312310.021
embryonic hemopoiesisGO:0035162530.021
determination of left right symmetryGO:00073681790.021
compound eye developmentGO:004874920.021
cellular metal ion homeostasisGO:0006875160.021
hindbrain developmentGO:0030902910.021
cellular protein catabolic processGO:004425740.021
wound healingGO:0042060900.021
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.020
tetrapyrrole metabolic processGO:0033013100.020
response to endogenous stimulusGO:0009719830.020
macromolecular complex disassemblyGO:003298410.020
regulation of cell communicationGO:00106462320.020
guanosine containing compound catabolic processGO:190106920.020
cellular response to hypoxiaGO:007145610.020
regulation of phosphorus metabolic processGO:0051174430.020
response to uvGO:000941130.019
positive regulation of rna metabolic processGO:0051254590.019
regulation of gtpase activityGO:004308720.019
toll like receptor signaling pathwayGO:000222440.019
positive regulation of i kappab kinase nf kappab signalingGO:004312330.019
single organism nuclear importGO:190259330.019
cellular response to unfolded proteinGO:003462020.019
proteasomal protein catabolic processGO:001049820.019
regulation of signalingGO:00230512350.019
alpha amino acid metabolic processGO:190160530.019
negative regulation of metabolic processGO:0009892860.019
regulation of cell substrate adhesionGO:001081010.019
positive regulation of cellular processGO:00485222010.019
stem cell maintenanceGO:001982740.019
respiratory electron transport chainGO:002290420.019
chordate embryonic developmentGO:00430092710.019
cranial nerve developmentGO:0021545420.019
regulation of metal ion transportGO:001095940.019
protein import into nucleusGO:000660630.018
positive regulation of cellular component biogenesisGO:004408930.018
cellular ketone metabolic processGO:0042180110.018
purine nucleoside triphosphate biosynthetic processGO:000914520.018
regulation of protein complex assemblyGO:004325430.018
cell proliferationGO:0008283800.018
regulation of cellular ketone metabolic processGO:001056570.018
protein localization to plasma membraneGO:007265910.018
sensory organ developmentGO:00074233930.018
response to xenobiotic stimulusGO:0009410450.018
carboxylic acid catabolic processGO:004639530.018
response to temperature stimulusGO:0009266150.018
pigment biosynthetic processGO:004614890.018
modification dependent protein catabolic processGO:001994130.018
embryonic skeletal system morphogenesisGO:0048704930.017
osteoclast differentiationGO:003031610.017
regulation of protein transportGO:005122330.017
modification dependent macromolecule catabolic processGO:004363230.017
centrosome organizationGO:005129710.017
er nucleus signaling pathwayGO:000698420.017
organic acid catabolic processGO:001605430.017
extrinsic apoptotic signaling pathwayGO:009719130.017
regulation of cellular amino acid metabolic processGO:000652100.017
angiogenesisGO:00015251580.017
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.017
regulation of developmental processGO:00507932470.017
brain developmentGO:00074202930.017
water homeostasisGO:003010440.017
ribosome assemblyGO:004225510.017
camera type eye developmentGO:00430102220.017
cellular monovalent inorganic cation homeostasisGO:003000420.017
vesicle mediated transportGO:0016192220.017
small molecule catabolic processGO:004428230.016
somitogenesisGO:0001756870.016
septum transversum developmentGO:000334340.016
cellular response to oxygen levelsGO:007145310.016
nuclear importGO:005117030.016
regulation of erk1 and erk2 cascadeGO:007037240.016
erk1 and erk2 cascadeGO:007037140.016
stem cell proliferationGO:007208940.016
rna localizationGO:000640340.016
homeostasis of number of cellsGO:0048872620.016
positive regulation of response to stimulusGO:0048584800.016
exocytosisGO:000688710.016
cell morphogenesisGO:00009022890.016
positive regulation of gene expressionGO:0010628710.016
response to metal ionGO:0010038340.016
regulation of bmp signaling pathwayGO:0030510390.016
negative regulation of programmed cell deathGO:0043069580.015
regulation of cell activationGO:005086510.015
spindle assembly involved in meiosisGO:009030610.015
positive regulation of jnk cascadeGO:004633030.015
erythrocyte developmentGO:0048821240.015
tissue regenerationGO:0042246740.015
regulation of reactive oxygen species metabolic processGO:200037720.015
blood vessel developmentGO:00015682460.015
mesenchyme developmentGO:00604851270.015
monocarboxylic acid catabolic processGO:007232930.015
cellular protein modification processGO:00064641000.015
cofactor metabolic processGO:0051186150.015
positive regulation of immune effector processGO:000269930.015
response to other organismGO:0051707970.015
sensory organ morphogenesisGO:00905962000.015
nucleoside monophosphate catabolic processGO:000912540.015
deathGO:00162651210.015
purine containing compound biosynthetic processGO:0072522200.015
positive regulation of apoptotic signaling pathwayGO:200123510.015
liver developmentGO:0001889960.015
negative regulation of macromolecule metabolic processGO:0010605760.015
protein targeting to nucleusGO:004474430.014
positive regulation of cell cycleGO:004578730.014
regulation of transcription from rna polymerase iii promoterGO:000635910.014
developmental programmed cell deathGO:001062340.014
female meiotic divisionGO:000714320.014
head developmentGO:00603223030.014
regulation of bindingGO:005109830.014
positive regulation of macromolecule metabolic processGO:0010604930.014
cell substrate adhesionGO:003158940.014
determination of heart left right asymmetryGO:00613711170.014
positive regulation of nucleotide catabolic processGO:003081310.014
fatty acid catabolic processGO:000906210.014
cellular component assemblyGO:00226071700.014
protein acetylationGO:000647320.014
segmentationGO:0035282970.014
membrane fusionGO:006102520.014
determination of left right asymmetry in lateral mesodermGO:0003140200.014
cell morphogenesis involved in neuron differentiationGO:00486671630.014
antimicrobial humoral responseGO:001973020.014
meiotic spindle organizationGO:000021210.013
response to decreased oxygen levelsGO:0036293250.013
negative regulation of cytokine productionGO:000181810.013
somatic stem cell maintenanceGO:003501910.013
positive regulation of map kinase activityGO:004340630.013
establishment of rna localizationGO:005123630.013
negative regulation of rna metabolic processGO:0051253480.013
localization of cellGO:00516742440.013
protein complex disassemblyGO:004324110.013
cellular response to reactive oxygen speciesGO:003461420.013
positive regulation of biosynthetic processGO:0009891680.013
multicellular organismal homeostasisGO:0048871290.013
purine nucleoside monophosphate catabolic processGO:000912840.013
regulation of synaptic growth at neuromuscular junctionGO:000858210.013
b cell activationGO:004211320.013
response to oxidative stressGO:0006979110.013
regulation of endopeptidase activityGO:0052548230.013
cellular response to topologically incorrect proteinGO:003596720.013
intracellular transportGO:0046907320.013
cell motilityGO:00488702440.013
response to oxygen containing compoundGO:1901700550.013
cell migrationGO:00164772370.013
positive regulation of cellular amine metabolic processGO:003324000.013
ribonucleoside monophosphate catabolic processGO:000915840.013
translational initiationGO:000641330.013
neuromuscular process controlling balanceGO:005088530.013
macromolecule modificationGO:00434121110.013
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.013
production of molecular mediator of immune responseGO:000244020.013
regulation of protein import into nucleusGO:004230620.013
positive regulation of cytosolic calcium ion concentrationGO:000720440.013
defense responseGO:0006952470.013
positive regulation of cellular biosynthetic processGO:0031328680.013
cellular response to nutrient levelsGO:003166920.013
dorsal ventral pattern formationGO:00099531250.013
membrane repolarizationGO:008600920.013
negative regulation of protein complex assemblyGO:003133310.013
epithelial cell differentiationGO:00308551160.013
regulation of cellular protein catabolic processGO:190336210.013
cell cycle arrestGO:000705010.013
neurotransmitter transportGO:000683620.013
organelle fusionGO:004828430.012
nucleotide metabolic processGO:0009117280.012
regionalizationGO:00030022740.012
phosphate containing compound metabolic processGO:00067961080.012
heart valve formationGO:000318840.012
negative regulation of apoptotic processGO:0043066550.012
neuron projection developmentGO:00311751800.012
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.012
cell cycle g2 m phase transitionGO:004483940.012
response to organic cyclic compoundGO:0014070510.012
proepicardium developmentGO:000334240.012
response to radiationGO:0009314510.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
chloride transmembrane transportGO:190247640.012
negative regulation of chromosome organizationGO:200125110.012
cellular response to lipidGO:0071396390.012
cellular response to organic cyclic compoundGO:0071407380.012
cellular response to starvationGO:000926710.012
positive regulation of cytokine productionGO:000181920.012
peptide transportGO:001583310.012
negative regulation of translationGO:001714810.012
innate immune responseGO:0045087130.012
microtubule polymerizationGO:004678520.012
membrane invaginationGO:001032410.012
stem cell fate commitmentGO:004886510.012
sulfur compound metabolic processGO:0006790130.012
cellular response to molecule of bacterial originGO:007121930.012
metencephalon developmentGO:0022037270.012
female gonad developmentGO:000858540.012
mitochondrion morphogenesisGO:007058420.012
inorganic anion transmembrane transportGO:0098661100.012
cellular component movementGO:00069283350.012
response to carbohydrateGO:000974330.012
morphogenesis of an epitheliumGO:00020093330.012
outflow tract morphogenesisGO:000315110.012
negative regulation of signal transductionGO:0009968940.012
regulation of circadian rhythmGO:004275240.012
regulation of type i interferon productionGO:003247920.012
fin developmentGO:0033333770.012
positive regulation of gtpase activityGO:004354710.012
cellular response to growth factor stimulusGO:0071363390.012
regulation of molecular functionGO:0065009700.012
single organism intracellular transportGO:1902582250.012
cellular component biogenesisGO:00440851780.011
regulation of gtp catabolic processGO:003312420.011
regulation of dendrite developmentGO:005077330.011
positive regulation of leukocyte mediated immunityGO:000270510.011
cytoskeleton dependent cytokinesisGO:006164030.011
positive regulation of protein complex assemblyGO:003133420.011
cell growthGO:0016049570.011
positive regulation of cell activationGO:005086710.011
bmp signaling pathwayGO:0030509520.011
digestive tract morphogenesisGO:00485462310.011
cellular response to extracellular stimulusGO:003166820.011
monovalent inorganic cation transportGO:0015672420.011
neurotransmitter secretionGO:000726920.011
cellular homeostasisGO:0019725260.011
cellular cation homeostasisGO:0030003170.011
response to woundingGO:00096111160.011
regulation of protein localization to nucleusGO:190018020.011
oxidative phosphorylationGO:000611910.011
positive regulation of macromolecule biosynthetic processGO:0010557590.011
negative regulation of epithelial cell proliferationGO:005068010.011
regulation of response to biotic stimulusGO:000283120.011
iron ion transmembrane transportGO:003475530.011
axon guidanceGO:0007411860.011
epithelial cell morphogenesisGO:000338220.011
intracellular signal transductionGO:0035556850.011
regulation of synapse organizationGO:005080730.011
protein secretionGO:000930610.011
polarized epithelial cell differentiationGO:003085940.011
glycoprotein biosynthetic processGO:0009101210.011
regulation of nucleocytoplasmic transportGO:004682220.011
centrosome cycleGO:000709810.011
innate immune response activating signal transductionGO:000275850.011
negative regulation of neural precursor cell proliferationGO:200017810.011
negative regulation of gene expressionGO:0010629650.011
toxin transportGO:190199820.011
regulation of proteolysisGO:0030162240.011
multi organism processGO:00517041340.011
interferon beta productionGO:003260810.011
single organism membrane fusionGO:004480120.011
protein depolymerizationGO:005126110.011
cellular response to biotic stimulusGO:007121630.011
appendage developmentGO:0048736800.010
regulation of protein metabolic processGO:0051246560.010
mesoderm developmentGO:0007498880.010
response to alkaloidGO:004327920.010

slc11a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:005068600.093
disease of cellular proliferationDOID:1456600.093
cancerDOID:16200.093
disease of anatomical entityDOID:700.049
nervous system diseaseDOID:86300.049
disease of metabolismDOID:001466700.044
endocrine gland cancerDOID:17000.016
musculoskeletal system diseaseDOID:1700.014
colorectal cancerDOID:925600.013
large intestine cancerDOID:567200.013
colon cancerDOID:21900.013
colon carcinomaDOID:152000.013
gastrointestinal system cancerDOID:311900.013
intestinal cancerDOID:1015500.013
inherited metabolic disorderDOID:65500.012