Danio rerio

35 known processes

nsmaf

neutral sphingomyelinase (N-SMase) activation associated factor

(Aliases: zgc:111982)

nsmaf biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cognitionGO:005089010.114
larval developmentGO:000216420.074
regulation of protein complex assemblyGO:004325430.072
muscle structure developmentGO:00610611960.064
cellular biosynthetic processGO:00442492860.063
lipid catabolic processGO:001604240.057
agingGO:000756820.056
negative regulation of protein transportGO:005122430.055
establishment of protein localization to organelleGO:007259440.051
regulation of establishment of protein localizationGO:007020140.051
gene expressionGO:00104672520.049
cellular macromolecule metabolic processGO:00442603910.049
protein localization to nucleusGO:003450430.048
biosynthetic processGO:00090582940.047
regulation of metabolic processGO:00192223590.047
myotube differentiationGO:0014902450.047
single organism nuclear importGO:190259330.047
maintenance of locationGO:005123540.047
regulation of macromolecule metabolic processGO:00602553170.046
nuclear transportGO:005116940.046
regulation of cytoplasmic transportGO:190364940.045
nucleocytoplasmic transportGO:000691340.045
striated muscle cell differentiationGO:00511461290.045
regulation of cellular metabolic processGO:00313233200.044
response to drugGO:004249330.044
protein importGO:001703830.043
response to external stimulusGO:00096052640.042
sensory organ developmentGO:00074233930.042
regulation of protein localization to nucleusGO:190018020.042
muscle cell differentiationGO:00426921390.042
regulation of protein transportGO:005122330.042
protein import into nucleusGO:000660630.041
nitrogen compound metabolic processGO:00068073190.041
response to chemicalGO:00422213200.041
negative regulation of cytoplasmic transportGO:190365020.041
regulation of nitrogen compound metabolic processGO:00511712510.041
regulation of intracellular protein transportGO:003315730.041
cell surface receptor signaling pathwayGO:00071663250.041
regulation of nucleic acid templated transcriptionGO:19035062130.040
cellular nitrogen compound metabolic processGO:00346412900.040
negative regulation of protein localization to nucleusGO:190018120.039
chordate embryonic developmentGO:00430092710.039
immune system processGO:00023762410.039
organic substance biosynthetic processGO:19015762890.038
regulation of nucleocytoplasmic transportGO:004682220.038
nuclear importGO:005117030.038
neuron differentiationGO:00301823530.038
autophagyGO:000691440.036
proteolysis involved in cellular protein catabolic processGO:005160330.036
protein targeting to nucleusGO:004474430.036
regulation of signalingGO:00230512350.036
positive regulation of transportGO:005105020.036
cellular component morphogenesisGO:00329893360.036
response to stressGO:00069502630.036
negative regulation of intracellular protein transportGO:009031730.035
regulation of cell communicationGO:00106462320.035
transcription dna templatedGO:00063511810.035
signal transductionGO:00071654550.035
regulation of primary metabolic processGO:00800903110.035
cellular macromolecule biosynthetic processGO:00346452240.035
ubiquitin dependent protein catabolic processGO:000651130.035
ribonucleoside monophosphate catabolic processGO:000915840.035
single organism metabolic processGO:00447102170.035
organic cyclic compound metabolic processGO:19013603010.035
cellular protein catabolic processGO:004425740.034
phagocytosisGO:000690930.034
cellular nitrogen compound biosynthetic processGO:00442712180.034
regulation of response to stimulusGO:00485832690.034
regulation of protein targetingGO:190353320.034
nucleic acid templated transcriptionGO:00976591810.034
system processGO:00030081850.034
establishment of localizationGO:00512342440.034
cellular component biogenesisGO:00440851780.033
cellular component assemblyGO:00226071700.033
embryonic organ developmentGO:00485683810.033
cellular response to chemical stimulusGO:00708871570.033
macromolecule biosynthetic processGO:00090592270.032
regulation of rna biosynthetic processGO:20011412130.032
generation of neuronsGO:00486993850.031
cellular aromatic compound metabolic processGO:00067252950.031
negative regulation of nucleocytoplasmic transportGO:004682320.031
nucleic acid metabolic processGO:00903042440.031
multicellular organism growthGO:003526440.031
purine ribonucleoside monophosphate catabolic processGO:000916940.031
rna metabolic processGO:00160702190.031
amine metabolic processGO:000930820.031
heterocycle metabolic processGO:00464832900.031
regulation of protein import into nucleusGO:004230620.031
nucleobase containing compound metabolic processGO:00061392740.031
modification dependent protein catabolic processGO:001994130.031
nucleobase containing compound biosynthetic processGO:00346542050.031
digestive tract developmentGO:00485652650.030
positive regulation of catabolic processGO:000989640.030
modification dependent macromolecule catabolic processGO:004363230.030
striated muscle tissue developmentGO:00147061100.030
heterocycle biosynthetic processGO:00181302150.030
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.030
negative regulation of protein phosphorylationGO:000193340.029
regulation of biosynthetic processGO:00098892500.029
neuron developmentGO:00486662620.029
regulation of multicellular organism growthGO:004001440.029
atp catabolic processGO:000620040.029
regulation of cytokine productionGO:000181730.029
sensory organ morphogenesisGO:00905962000.029
positive regulation of biological processGO:00485182530.028
organic cyclic compound biosynthetic processGO:19013622230.028
regulation of developmental processGO:00507932470.028
regulation of biological qualityGO:00650082630.028
purine nucleoside monophosphate catabolic processGO:000912840.028
negative regulation of protein import into nucleusGO:004230820.028
positive regulation of cell cycleGO:004578730.027
positive regulation of cellular catabolic processGO:003133130.027
rna biosynthetic processGO:00327741810.027
determination of bilateral symmetryGO:00098552040.027
enzyme linked receptor protein signaling pathwayGO:00071671060.027
regulation of signal transductionGO:00099662250.027
homeostatic processGO:00425921420.027
stem cell maintenanceGO:001982740.026
cellular amine metabolic processGO:004410620.026
skeletal muscle tissue developmentGO:0007519670.026
muscle tissue developmentGO:00605371100.026
nucleoside monophosphate catabolic processGO:000912540.026
regulation of cellular amino acid metabolic processGO:000652100.026
regulation of macromolecule biosynthetic processGO:00105562250.026
regulation of cellular macromolecule biosynthetic processGO:20001122220.025
mitochondrion organizationGO:000700540.025
negative regulation of intracellular transportGO:003238730.025
positive regulation of cellular component biogenesisGO:004408930.025
proteasomal protein catabolic processGO:001049820.025
regulation of cellular biosynthetic processGO:00313262450.025
regulation of metal ion transportGO:001095940.025
regulation of protein catabolic processGO:004217610.025
organelle fusionGO:004828430.025
aromatic compound biosynthetic processGO:00194382170.025
immune system developmentGO:00025201910.025
regulation of autophagyGO:001050630.024
regulation of multicellular organismal processGO:00512392770.024
specification of symmetryGO:00097992040.024
cellular ketone metabolic processGO:0042180110.024
regulation of reproductive processGO:200024140.024
cellular response to molecule of bacterial originGO:007121930.024
regulation of cellular amine metabolic processGO:003323800.023
response to organic substanceGO:00100331530.023
regulation of cell activationGO:005086510.023
transportGO:00068102200.023
single organism transportGO:00447652060.023
response to virusGO:0009615210.023
exocytosisGO:000688710.023
rna localizationGO:000640340.023
regulation of gene expressionGO:00104682650.023
meiotic nuclear divisionGO:000712640.023
cellular response to organic substanceGO:00713101050.023
regulation of transcription dna templatedGO:00063552130.023
negative regulation of biological processGO:00485193040.023
cytokinesisGO:000091030.023
synaptic growth at neuromuscular junctionGO:005112420.023
regulation of programmed cell deathGO:00430671010.023
membrane fusionGO:006102520.022
extrinsic apoptotic signaling pathwayGO:009719130.022
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.022
negative regulation of cellular processGO:00485232830.022
locomotor rhythmGO:004547530.022
head developmentGO:00603223030.022
regulation of cellular ketone metabolic processGO:001056570.022
cell part morphogenesisGO:00329902460.022
regulation of rna metabolic processGO:00512522240.021
organic acid metabolic processGO:0006082310.021
tube morphogenesisGO:00352393490.021
skeletal muscle organ developmentGO:0060538780.021
transcription from rna polymerase ii promoterGO:0006366800.021
oxoacid metabolic processGO:0043436310.021
multi organism processGO:00517041340.021
positive regulation of protein complex assemblyGO:003133420.021
embryo development ending in birth or egg hatchingGO:00097922710.021
protein acetylationGO:000647320.021
cell deathGO:00082191210.021
negative regulation of kinase activityGO:003367340.021
retina development in camera type eyeGO:00600411460.021
heart developmentGO:00075073130.021
cell morphogenesisGO:00009022890.021
cytoskeleton dependent cytokinesisGO:006164030.021
eye developmentGO:00016542770.020
negative regulation of protein kinase activityGO:000646940.020
digestive system developmentGO:00551232890.020
liver developmentGO:0001889960.020
protein localization to plasma membraneGO:007265910.020
hematopoietic or lymphoid organ developmentGO:00485341910.020
retina morphogenesis in camera type eyeGO:0060042790.020
neurotransmitter transportGO:000683620.020
regulation of bindingGO:005109830.020
regulation of apoptotic processGO:0042981980.020
camera type eye developmentGO:00430102220.020
cellular response to external stimulusGO:007149620.020
single organism localizationGO:19025782250.020
internal peptidyl lysine acetylationGO:001839320.020
positive regulation of muscle cell differentiationGO:005114910.020
response to external biotic stimulusGO:0043207970.020
erythrocyte homeostasisGO:0034101550.020
hemopoiesisGO:00300971830.020
i kappab kinase nf kappab signalingGO:000724940.019
lipid storageGO:001991510.019
regulation of cell differentiationGO:00455951420.019
single organism membrane fusionGO:004480120.019
internal protein amino acid acetylationGO:000647520.019
muscle cell developmentGO:00550011150.019
cellular response to nutrient levelsGO:003166920.019
peptidyl lysine acetylationGO:001839420.019
neurotransmitter secretionGO:000726920.019
positive regulation of cellular processGO:00485222010.019
myeloid cell homeostasisGO:0002262560.019
gtp catabolic processGO:000618420.019
gtp metabolic processGO:004603940.019
response to uvGO:000941130.019
cell projection morphogenesisGO:00488582440.019
cell substrate adhesionGO:003158940.019
macromolecule modificationGO:00434121110.019
guanosine containing compound metabolic processGO:190106840.019
symbiosis encompassing mutualism through parasitismGO:004440340.019
regulation of myotube differentiationGO:001083020.019
positive regulation of cellular amino acid metabolic processGO:004576400.018
striated muscle cell developmentGO:00550021080.018
skeletal system morphogenesisGO:00487051020.018
protein metabolic processGO:00195381830.018
synaptic vesicle localizationGO:009747910.018
cellular amino acid metabolic processGO:000652070.018
cellular component movementGO:00069283350.018
deathGO:00162651210.018
determination of left right symmetryGO:00073681790.018
organonitrogen compound metabolic processGO:1901564740.018
antimicrobial humoral responseGO:001973020.018
response to biotic stimulusGO:0009607970.018
positive regulation of secretionGO:005104710.018
guanosine containing compound catabolic processGO:190106920.018
neurological system processGO:0050877620.018
skeletal muscle fiber developmentGO:0048741350.018
erythrocyte differentiationGO:0030218540.018
positive regulation of cell activationGO:005086710.018
peptidyl serine modificationGO:001820920.018
regulation of synapse organizationGO:005080730.017
regulation of localizationGO:00328791040.017
mesenchyme developmentGO:00604851270.017
meiotic cell cycle processGO:190304630.017
cellular response to biotic stimulusGO:007121630.017
regulation of extrinsic apoptotic signaling pathwayGO:200123630.017
small molecule metabolic processGO:0044281770.017
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.017
leukocyte proliferationGO:007066110.017
cellular amide metabolic processGO:004360340.017
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.017
adult behaviorGO:003053420.017
golgi vesicle transportGO:004819330.017
neuron neuron synaptic transmissionGO:000727010.017
homeostasis of number of cellsGO:0048872620.017
positive regulation of lymphocyte mediated immunityGO:000270810.017
cartilage developmentGO:0051216960.017
regulation of alternative mrna splicing via spliceosomeGO:000038110.017
carboxylic acid metabolic processGO:0019752220.017
erk1 and erk2 cascadeGO:007037140.017
endosomal transportGO:001619720.017
cellular response to lipopolysaccharideGO:007122230.017
macromolecular complex subunit organizationGO:0043933740.017
cellular response to extracellular stimulusGO:003166820.017
positive regulation of cellular metabolic processGO:0031325940.017
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.017
central nervous system developmentGO:00074173870.017
behaviorGO:0007610740.017
regulation of cell shapeGO:000836010.017
protein dephosphorylationGO:000647030.016
positive regulation of cytoskeleton organizationGO:005149530.016
negative regulation of cell communicationGO:0010648960.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
regulation of multicellular organismal developmentGO:20000262230.016
cell morphogenesis involved in differentiationGO:00009041950.016
cell projection organizationGO:00300302840.016
cellular response to starvationGO:000926710.016
programmed cell deathGO:00125011190.016
regulation of erk1 and erk2 cascadeGO:007037240.016
myeloid cell differentiationGO:0030099860.016
muscle organ developmentGO:00075171010.016
neuron projection morphogenesisGO:00488121610.016
brain developmentGO:00074202930.016
regulation of protein ubiquitinationGO:003139630.016
response to topologically incorrect proteinGO:003596620.016
myotube cell developmentGO:0014904350.016
regulation of peptidyl tyrosine phosphorylationGO:005073010.016
regulation of calcium ion transportGO:005192420.016
negative regulation of protein complex assemblyGO:003133310.016
muscle fiber developmentGO:0048747520.016
compound eye developmentGO:004874920.016
mononuclear cell proliferationGO:003294310.016
regulation of cellular protein catabolic processGO:190336210.015
tissue remodelingGO:004877140.015
cellular carbohydrate metabolic processGO:004426240.015
skeletal system developmentGO:00015011810.015
positive regulation of cellular amine metabolic processGO:003324000.015
regulation of i kappab kinase nf kappab signalingGO:004312240.015
positive regulation of immune effector processGO:000269930.015
response to abiotic stimulusGO:00096281220.015
regulation of dendrite developmentGO:005077330.015
positive regulation of macromolecule metabolic processGO:0010604930.015
response to other organismGO:0051707970.015
peptide transportGO:001583310.015
primary neural tube formationGO:001402010.015
negative regulation of response to stimulusGO:00485851040.015
intracellular mrna localizationGO:000829810.015
connective tissue developmentGO:0061448990.015
interspecies interaction between organismsGO:004441940.015
double strand break repairGO:000630230.015
adherens junction organizationGO:003433240.015
female sex differentiationGO:004666040.015
negative regulation of metabolic processGO:0009892860.015
response to bacteriumGO:0009617580.015
negative regulation of catabolic processGO:000989530.015
positive regulation of nitrogen compound metabolic processGO:0051173690.015
regulation of synaptic plasticityGO:004816710.015
development of primary female sexual characteristicsGO:004654540.015
cellular protein metabolic processGO:00442671290.015
negative regulation of protein serine threonine kinase activityGO:007190120.015
negative regulation of cellular metabolic processGO:0031324770.015
regulation of cellular component organizationGO:0051128860.015
positive regulation of cytosolic calcium ion concentrationGO:000720440.015
multi organism cellular processGO:004476420.015
somatic muscle developmentGO:000752540.015
regulation of transcription from rna polymerase ii promoterGO:00063571140.015
negative regulation of cytokine productionGO:000181810.015
tube closureGO:006060610.015
cell cycle g1 s phase transitionGO:004484310.015
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.014
cellular response to endogenous stimulusGO:0071495680.014
regionalizationGO:00030022740.014
viral processGO:001603210.014
intracellular signal transductionGO:0035556850.014
regulation of neurotransmitter transportGO:005158810.014
negative regulation of signal transductionGO:0009968940.014
regulation of purine nucleotide catabolic processGO:003312120.014
cell motilityGO:00488702440.014
regulation of transmembrane transporter activityGO:002289820.014
stem cell divisionGO:001714510.014
protein acylationGO:004354330.014
regulation of cell deathGO:00109411030.014
regulation of dna replicationGO:000627530.014
protein secretionGO:000930610.014
protein polyubiquitinationGO:000020940.014
membrane invaginationGO:001032410.014
regulation of nucleoside metabolic processGO:000911820.014
regulation of ion transmembrane transporter activityGO:003241220.014
peptide metabolic processGO:000651810.014
establishment of synaptic vesicle localizationGO:009748010.014
positive regulation of metabolic processGO:00098931080.014
regulation of synaptic growth at neuromuscular junctionGO:000858210.014
regulation of synapse assemblyGO:005196330.014
positive regulation of multi organism processGO:004390230.014
regulation of dendrite morphogenesisGO:004881430.014
chemosensory behaviorGO:000763510.014
spermatid differentiationGO:004851520.014
peptidyl serine phosphorylationGO:001810510.014
rna modificationGO:000945120.014
regulation of stem cell proliferationGO:007209120.014
negative regulation of mapk cascadeGO:004340940.014
phagocytosis engulfmentGO:000691110.014
spermatid developmentGO:000728620.014
synaptic vesicle transportGO:004848910.014
negative regulation of signalingGO:0023057960.014
lateral inhibitionGO:004633110.014
signal transduction in absence of ligandGO:003803410.014
locomotionGO:00400113130.014
lymphocyte proliferationGO:004665110.014
mesoderm developmentGO:0007498880.014
single organism organelle organizationGO:19025891990.013
pancreas developmentGO:0031016840.013
microtubule organizing center organizationGO:003102310.013
camera type eye morphogenesisGO:00485931080.013
positive regulation of purine nucleotide catabolic processGO:003312310.013
positive regulation of chromatin modificationGO:190331010.013
regulation of molecular functionGO:0065009700.013
positive regulation of i kappab kinase nf kappab signalingGO:004312330.013
macroautophagyGO:001623610.013
carbohydrate homeostasisGO:003350010.013
organelle organizationGO:00069962270.013
positive regulation of dna metabolic processGO:005105410.013
b cell activationGO:004211320.013
regulation of epithelial cell proliferationGO:005067830.013
positive regulation of apoptotic signaling pathwayGO:200123510.013
cell morphogenesis involved in neuron differentiationGO:00486671630.013
regulation of response to biotic stimulusGO:000283120.013
morphogenesis of an epitheliumGO:00020093330.013
positive regulation of nucleoside metabolic processGO:004597910.013
cytosolic calcium ion transportGO:006040130.013
urogenital system developmentGO:0001655970.013
regulation of carbohydrate metabolic processGO:000610940.013
blood vessel developmentGO:00015682460.013
production of molecular mediator of immune responseGO:000244020.013
fin developmentGO:0033333770.013
regulation of nucleotide catabolic processGO:003081120.013
positive regulation of nucleotide catabolic processGO:003081310.013
regulation of nucleobase containing compound metabolic processGO:00192192500.013
negative regulation of secretionGO:005104820.013
regulation of neurotransmitter secretionGO:004692810.013
digestive tract morphogenesisGO:00485462310.013
regulation of mrna processingGO:005068430.013
stem cell proliferationGO:007208940.013
negative regulation of cellular catabolic processGO:003133030.013
positive regulation of erk1 and erk2 cascadeGO:007037420.013
developmental growthGO:00485891660.013
eye morphogenesisGO:00485921440.013
cellular protein modification processGO:00064641000.013
cellular localizationGO:0051641970.013
cytoplasm organizationGO:000702840.013
regulation of anatomical structure morphogenesisGO:00226031300.013
regulation of production of molecular mediator of immune responseGO:000270010.013
kidney developmentGO:0001822920.013
positive regulation of cell adhesionGO:004578510.013
epithelial cell differentiationGO:00308551160.012
cell migrationGO:00164772370.012
small molecule catabolic processGO:004428230.012
centrosome duplicationGO:005129810.012
regulation of transporter activityGO:003240920.012
axonogenesisGO:00074091520.012
protein modification processGO:00362111000.012
developmental programmed cell deathGO:001062340.012
negative regulation of defense responseGO:003134820.012
axon developmentGO:00615641660.012
cortical cytoskeleton organizationGO:003086510.012
cellular component disassemblyGO:002241110.012
hepaticobiliary system developmentGO:0061008980.012
neuromuscular synaptic transmissionGO:000727420.012
positive regulation of histone modificationGO:003105810.012
lipid homeostasisGO:005508830.012
germ line stem cell maintenanceGO:003071820.012
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.012
response to coldGO:000940940.012
cellular response to radiationGO:007147840.012
cellular response to topologically incorrect proteinGO:003596720.012
regulation of inflammatory responseGO:005072720.012
actin filament polymerizationGO:003004120.012
positive regulation of chromosome organizationGO:200125210.012
gastrulationGO:00073692080.012
establishment of protein localization to plasma membraneGO:009000210.012
photoreceptor cell differentiationGO:0046530550.012
cellular response to light stimulusGO:007148240.012
hormone secretionGO:004687920.012
cell matrix adhesionGO:000716040.012
negative regulation of map kinase activityGO:004340720.012
regulation of jak stat cascadeGO:004642530.012
centrosome organizationGO:005129710.012
mitotic cytokinesisGO:000028130.012
meiotic chromosome segregationGO:004513230.011
regulation of protein bindingGO:004339330.011
regulation of gtpase activityGO:004308720.011
nucleic acid transportGO:005065720.011
centrosome cycleGO:000709810.011
macromolecular complex disassemblyGO:003298410.011
actin polymerization or depolymerizationGO:000815420.011
response to hormoneGO:0009725480.011
post embryonic organ developmentGO:004856940.011
response to carbohydrateGO:000974330.011
single fertilizationGO:000733830.011
neural retina developmentGO:0003407490.011
positive regulation of secretion by cellGO:190353210.011
negative regulation of epithelial cell proliferationGO:005068010.011
cellular response to oxygen levelsGO:007145310.011
regulation of sequestering of calcium ionGO:005128240.011
organic acid catabolic processGO:001605430.011
transcription elongation from rna polymerase ii promoterGO:000636830.011
protein complex biogenesisGO:0070271300.011
lipid oxidationGO:003444010.011
appendage developmentGO:0048736800.011
negative regulation of nuclear divisionGO:005178430.011
activation of mapk activityGO:000018730.011
pectoral fin developmentGO:0033339500.011
sequestering of calcium ionGO:005120830.011
cytokinetic processGO:003250620.011
toll like receptor signaling pathwayGO:000222440.011
cellular macromolecular complex assemblyGO:0034622240.011
protein polymerizationGO:005125840.011
mitotic dna integrity checkpointGO:004477440.011
double strand break repair via homologous recombinationGO:000072410.011
regulation of neural precursor cell proliferationGO:200017730.011
female gonad developmentGO:000858540.011
g1 s transition of mitotic cell cycleGO:000008210.011
response to endogenous stimulusGO:0009719830.011
secondary metabolic processGO:001974830.011
regulation of exocytosisGO:001715710.011
negative regulation of cellular biosynthetic processGO:0031327550.011
neuroblast proliferationGO:000740520.011

nsmaf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.085
musculoskeletal system diseaseDOID:1700.019
nervous system diseaseDOID:86300.019
cancerDOID:16200.016
disease of cellular proliferationDOID:1456600.016
organ system cancerDOID:005068600.016
disease of metabolismDOID:001466700.016
inherited metabolic disorderDOID:65500.013
muscular diseaseDOID:008000000.012
muscle tissue diseaseDOID:6600.012