Danio rerio

0 known processes

kpna4

karyopherin alpha 4 (importin alpha 3)

(Aliases: wu:fe14c04,wu:fi19b05,wu:fa66g10,wu:fi04h11,impa3,wu:fa56d07)

kpna4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.544
Worm
regulation of synapse organizationGO:005080730.452
negative regulation of biological processGO:00485193040.427
Worm Fly
cell migrationGO:00164772370.374
regulation of primary metabolic processGO:00800903110.368
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.305
regulation of gene expressionGO:00104682650.273
Worm
cellular macromolecule metabolic processGO:00442603910.270
regulation of cellular metabolic processGO:00313233200.266
cellular component movementGO:00069283350.263
gene expressionGO:00104672520.262
Worm
localization of cellGO:00516742440.257
proteasomal protein catabolic processGO:001049820.253
ubiquitin dependent protein catabolic processGO:000651130.251
proteolysis involved in cellular protein catabolic processGO:005160330.223
cell cycle processGO:0022402530.219
Worm Fly
regulation of multicellular organism growthGO:004001440.205
regulation of multicellular organismal developmentGO:20000262230.200
regulation of synaptic growth at neuromuscular junctionGO:000858210.200
meiotic nuclear divisionGO:000712640.197
Worm
locomotionGO:00400113130.197
Worm
regulation of macromolecule metabolic processGO:00602553170.188
Worm
cell motilityGO:00488702440.187
neuron projection developmentGO:00311751800.183
regulation of developmental processGO:00507932470.176
cytokinesisGO:000091030.176
negative regulation of cellular processGO:00485232830.175
Fly
regulation of meiotic cell cycleGO:005144510.168
positive regulation of biological processGO:00485182530.156
Fly
regulation of rna metabolic processGO:00512522240.155
modification dependent protein catabolic processGO:001994130.151
regulation of cellular biosynthetic processGO:00313262450.145
regulation of multicellular organismal processGO:00512392770.142
immune system processGO:00023762410.140
single organism organelle organizationGO:19025891990.135
Worm
modification dependent macromolecule catabolic processGO:004363230.135
regulation of response to stimulusGO:00485832690.131
regulation of synapse assemblyGO:005196330.129
cellular nitrogen compound metabolic processGO:00346412900.126
regulation of signalingGO:00230512350.126
determination of bilateral symmetryGO:00098552040.126
cellular component biogenesisGO:00440851780.125
regulation of cell shapeGO:000836010.124
signal transductionGO:00071654550.123
skeletal system developmentGO:00015011810.119
synaptic growth at neuromuscular junctionGO:005112420.113
organelle organizationGO:00069962270.112
Worm
cell surface receptor signaling pathwayGO:00071663250.111
multicellular organism growthGO:003526440.109
cellular protein catabolic processGO:004425740.109
specification of symmetryGO:00097992040.104
response to biotic stimulusGO:0009607970.100
multi organism processGO:00517041340.099
Worm
negative regulation of small gtpase mediated signal transductionGO:005105810.099
regulation of metabolic processGO:00192223590.098
Worm
nuclear importGO:005117030.098
Mouse Worm Fly
cell morphogenesisGO:00009022890.098
cellular protein metabolic processGO:00442671290.096
transportGO:00068102200.095
Mouse Worm Fly
positive regulation of cellular component biogenesisGO:004408930.093
positive regulation of chromosome organizationGO:200125210.091
convergent extensionGO:00600261180.090
hematopoietic or lymphoid organ developmentGO:00485341910.090
stem cell maintenanceGO:001982740.087
negative regulation of response to stimulusGO:00485851040.086
behaviorGO:0007610740.084
nitrogen compound metabolic processGO:00068073190.084
heterocycle metabolic processGO:00464832900.083
regulation of cell communicationGO:00106462320.083
neuron differentiationGO:00301823530.081
cellular amine metabolic processGO:004410620.081
response to other organismGO:0051707970.080
organelle fissionGO:0048285230.078
Worm
single organism transportGO:00447652060.075
Mouse Worm Fly
morphogenesis of an epitheliumGO:00020093330.075
alternative mrna splicing via spliceosomeGO:000038010.073
growthGO:00400071740.073
chordate embryonic developmentGO:00430092710.073
protein metabolic processGO:00195381830.072
positive regulation of transportGO:005105020.069
Fly
regulation of alternative mrna splicing via spliceosomeGO:000038110.067
cellular protein modification processGO:00064641000.067
negative regulation of synapse assemblyGO:005196420.066
homeostatic processGO:00425921420.066
adult behaviorGO:003053420.065
regulation of cellular macromolecule biosynthetic processGO:20001122220.065
regulation of cellular component organizationGO:0051128860.064
mitotic cell cycle processGO:1903047480.063
Fly
positive regulation of cellular processGO:00485222010.063
Fly
axon developmentGO:00615641660.062
response to chemicalGO:00422213200.062
Mouse
hemopoiesisGO:00300971830.061
spindle assemblyGO:005122520.061
embryo development ending in birth or egg hatchingGO:00097922710.061
Worm
embryonic organ morphogenesisGO:00485622740.060
response to stressGO:00069502630.060
Mouse Fly
regulation of developmental growthGO:0048638380.060
establishment of localizationGO:00512342440.058
Mouse Worm Fly
developmental growthGO:00485891660.057
response to external stimulusGO:00096052640.056
response to organic substanceGO:00100331530.056
single organism localizationGO:19025782250.056
Mouse Worm Fly
embryonic organ developmentGO:00485683810.055
regulation of biological qualityGO:00650082630.055
cytoskeleton organizationGO:0007010960.055
neuroblast proliferationGO:000740520.055
cell part morphogenesisGO:00329902460.054
cellular ketone metabolic processGO:0042180110.054
cellular component morphogenesisGO:00329893360.053
heart developmentGO:00075073130.053
regulation of nitrogen compound metabolic processGO:00511712510.053
regulation of cell cycleGO:0051726520.052
Fly
protein localization to nucleusGO:003450430.052
Mouse Worm Fly
cell divisionGO:0051301200.052
organic cyclic compound metabolic processGO:19013603010.052
regulation of macromolecule biosynthetic processGO:00105562250.052
regulation of cell differentiationGO:00455951420.052
immune system developmentGO:00025201910.051
heterocycle biosynthetic processGO:00181302150.051
regulation of cell deathGO:00109411030.051
cell morphogenesis involved in differentiationGO:00009041950.050
positive regulation of chromatin modificationGO:190331010.050
regulation of cellular amine metabolic processGO:003323800.050
negative regulation of metabolic processGO:0009892860.049
Worm
regulation of nuclear divisionGO:005178390.048
nuclear divisionGO:0000280230.048
Worm
regulation of cell divisionGO:0051302120.048
proteolysisGO:0006508380.047
generation of neuronsGO:00486993850.047
positive regulation of cellular amino acid metabolic processGO:004576400.046
blood vessel morphogenesisGO:00485142160.046
negative regulation of nuclear divisionGO:005178430.046
regulation of cellular ketone metabolic processGO:001056570.045
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.044
embryonic skeletal system developmentGO:0048706970.043
embryonic heart tube developmentGO:00350501330.043
positive regulation of macromolecule metabolic processGO:0010604930.043
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.043
phosphorylationGO:0016310690.042
cognitionGO:005089010.042
regulation of signal transductionGO:00099662250.042
regulation of biosynthetic processGO:00098892500.041
oxoacid metabolic processGO:0043436310.041
mitotic nuclear divisionGO:0007067180.041
regionalizationGO:00030022740.040
cellular component assemblyGO:00226071700.040
amine metabolic processGO:000930820.039
cell proliferationGO:0008283800.039
regulation of chromosome segregationGO:005198310.039
negative regulation of developmental processGO:0051093650.039
regulation of transcription from rna polymerase ii promoterGO:00063571140.039
organic acid metabolic processGO:0006082310.039
response to endogenous stimulusGO:0009719830.038
positive regulation of cellular catabolic processGO:003133130.038
regulation of reproductive processGO:200024140.038
heart loopingGO:0001947940.038
regulation of cell activationGO:005086510.038
regulation of rna biosynthetic processGO:20011412130.038
vasculature developmentGO:00019442780.037
regulation of nucleobase containing compound metabolic processGO:00192192500.037
stem cell proliferationGO:007208940.037
blood vessel developmentGO:00015682460.037
phagocytosisGO:000690930.036
positive regulation of cellular metabolic processGO:0031325940.036
regulation of immune system processGO:0002682340.036
regulation of cell morphogenesisGO:0022604420.035
vesicle mediated transportGO:0016192220.035
nucleocytoplasmic transportGO:000691340.035
Mouse Worm Fly
cellular response to extracellular stimulusGO:003166820.035
transcription dna templatedGO:00063511810.035
protein import into nucleusGO:000660630.035
Mouse Worm Fly
regulation of cellular component movementGO:0051270550.035
protein importGO:001703830.034
Mouse Worm Fly
digestive tract developmentGO:00485652650.034
synapse organizationGO:0050808210.034
positive regulation of nitrogen compound metabolic processGO:0051173690.034
lateral inhibitionGO:004633110.034
mitotic cell cycleGO:0000278640.034
Fly
neuron developmentGO:00486662620.034
single organism metabolic processGO:00447102170.034
response to external biotic stimulusGO:0043207970.034
regulation of cellular protein catabolic processGO:190336210.034
regulation of nucleic acid templated transcriptionGO:19035062130.033
determination of left right symmetryGO:00073681790.033
negative regulation of ras protein signal transductionGO:004658010.033
carboxylic acid metabolic processGO:0019752220.033
regulation of organelle organizationGO:0033043290.033
regulation of cellular protein metabolic processGO:0032268520.033
embryonic heart tube morphogenesisGO:00031431080.032
tube morphogenesisGO:00352393490.032
macromolecular complex subunit organizationGO:0043933740.032
Worm
programmed cell deathGO:00125011190.032
negative regulation of macromolecule metabolic processGO:0010605760.032
Worm
autophagyGO:000691440.032
negative regulation of signal transductionGO:0009968940.032
nucleic acid metabolic processGO:00903042440.031
cellular localizationGO:0051641970.031
Mouse Worm Fly
regulation of mrna processingGO:005068430.031
epithelial tube morphogenesisGO:00605621480.031
negative regulation of cell communicationGO:0010648960.031
cell morphogenesis involved in neuron differentiationGO:00486671630.031
regulation of translational initiationGO:000644610.031
macromolecule modificationGO:00434121110.031
regulation of protein catabolic processGO:004217610.031
cellular response to starvationGO:000926710.030
negative regulation of mapk cascadeGO:004340940.030
regulation of protein import into nucleusGO:004230620.030
Fly
nucleobase containing compound metabolic processGO:00061392740.030
rna metabolic processGO:00160702190.030
regulation of cellular amino acid metabolic processGO:000652100.030
protein modification processGO:00362111000.029
cell projection morphogenesisGO:00488582440.029
positive regulation of cellular amine metabolic processGO:003324000.029
cell deathGO:00082191210.029
negative regulation of cellular component organizationGO:0051129160.028
establishment of protein localization to organelleGO:007259440.028
Mouse Worm Fly
positive regulation of metabolic processGO:00098931080.028
regulation of localizationGO:00328791040.028
Fly
negative regulation of multicellular organismal processGO:0051241690.028
microtubule based processGO:0007017600.028
morphogenesis of an epithelial foldGO:006057110.028
organic substance biosynthetic processGO:19015762890.028
system processGO:00030081850.028
aromatic compound biosynthetic processGO:00194382170.028
regulation of cytoplasmic transportGO:190364940.027
Fly
negative regulation of protein phosphorylationGO:000193340.027
meiosis iGO:000712710.027
Worm
deathGO:00162651210.027
myeloid cell differentiationGO:0030099860.026
anterior posterior pattern specificationGO:00099521520.026
nucleic acid templated transcriptionGO:00976591810.026
establishment of localization in cellGO:0051649770.026
Mouse Worm Fly
cellular biosynthetic processGO:00442492860.026
digestive system developmentGO:00551232890.025
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377100.025
cellular response to chemical stimulusGO:00708871570.025
response to woundingGO:00096111160.025
cell cycleGO:0007049930.025
Worm Fly
negative regulation of kinase activityGO:003367340.024
digestive tract morphogenesisGO:00485462310.024
protein targeting to nucleusGO:004474430.024
Mouse Worm Fly
cellular amino acid metabolic processGO:000652070.023
cell death in response to oxidative stressGO:003647320.023
regulation of protein targetingGO:190353320.023
Fly
axonogenesisGO:00074091520.023
positive regulation of cell cycleGO:004578730.022
negative regulation of map kinase activityGO:004340720.022
tissue remodelingGO:004877140.022
regulation of neuron projection developmentGO:0010975400.022
regulation of establishment of protein localizationGO:007020140.022
Fly
somitogenesisGO:0001756870.022
biosynthetic processGO:00090582940.022
stem cell divisionGO:001714510.022
microtubule cytoskeleton organizationGO:0000226330.021
regulation of peptidyl tyrosine phosphorylationGO:005073010.021
cellular nitrogen compound biosynthetic processGO:00442712180.021
positive regulation of nucleobase containing compound metabolic processGO:0045935690.021
erythrocyte differentiationGO:0030218540.021
dorsal ventral pattern formationGO:00099531250.021
determination of heart left right asymmetryGO:00613711170.021
regulation of cell migrationGO:0030334400.021
cell projection organizationGO:00300302840.021
cellular response to external stimulusGO:007149620.021
mrna splicing via spliceosomeGO:0000398100.021
wnt signaling pathwayGO:0016055800.020
positive regulation of cellular biosynthetic processGO:0031328680.020
nephron morphogenesisGO:007202820.020
maintenance of locationGO:005123540.020
macromolecule biosynthetic processGO:00090592270.020
positive regulation of dna metabolic processGO:005105410.020
regulation of growthGO:0040008420.020
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296810.020
transcription from rna polymerase ii promoterGO:0006366800.020
primary neural tube formationGO:001402010.020
positive regulation of catabolic processGO:000989640.020
cellular aromatic compound metabolic processGO:00067252950.020
regulation of cell motilityGO:2000145460.020
meiotic cell cycle processGO:190304630.019
Worm
regulation of cell cycle processGO:0010564200.019
Fly
positive regulation of cell divisionGO:005178120.019
regulation of neural precursor cell proliferationGO:200017730.019
cellular macromolecule biosynthetic processGO:00346452240.019
neuron projection morphogenesisGO:00488121610.018
regenerationGO:0031099910.018
regulation of intracellular protein transportGO:003315730.018
Fly
negative regulation of nitrogen compound metabolic processGO:0051172590.018
positive regulation of jun kinase activityGO:004350720.018
neuromuscular synaptic transmissionGO:000727420.018
developmental growth involved in morphogenesisGO:0060560860.018
regulation of protein metabolic processGO:0051246560.018
positive regulation of synapse assemblyGO:005196510.018
translational initiationGO:000641330.018
mitochondrial transportGO:000683920.018
cellular macromolecule catabolic processGO:0044265120.018
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.017
negative regulation of defense responseGO:003134820.017
apoptotic processGO:00069151160.017
regulation of cell developmentGO:00602841000.017
negative regulation of signalingGO:0023057960.017
meiotic spindle organizationGO:000021210.017
response to drugGO:004249330.017
single organism nuclear importGO:190259330.017
Mouse Worm Fly
intracellular signal transductionGO:0035556850.017
cortical actin cytoskeleton organizationGO:003086610.017
organonitrogen compound metabolic processGO:1901564740.017
response to temperature stimulusGO:0009266150.017
ion transportGO:00068111140.017
positive regulation of apoptotic signaling pathwayGO:200123510.017
cartilage developmentGO:0051216960.017
cell growthGO:0016049570.017
positive regulation of multicellular organismal processGO:0051240520.016
positive regulation of apoptotic processGO:0043065290.016
lysosomal transportGO:000704120.016
intracellular transportGO:0046907320.016
Mouse Worm Fly
regulation of response to external stimulusGO:0032101310.016
heart morphogenesisGO:00030071560.016
skeletal system morphogenesisGO:00487051020.016
positive regulation of programmed cell deathGO:0043068290.016
positive regulation of secretionGO:005104710.016
hepaticobiliary system developmentGO:0061008980.016
connective tissue developmentGO:0061448990.016
viral processGO:001603210.016
regulation of intracellular signal transductionGO:1902531570.016
odontogenesis of dentin containing toothGO:004247510.016
neurological system processGO:0050877620.016
protein acetylationGO:000647320.016
negative regulation of protein kinase activityGO:000646940.015
multi organism reproductive processGO:0044703360.015
Worm
stem cell developmentGO:0048864820.015
germ line stem cell divisionGO:004207810.015
rna biosynthetic processGO:00327741810.015
regulation of anterior head developmentGO:200074220.015
regulation of mitosisGO:000708890.015
regulation of response to stressGO:0080134360.015
centrosome cycleGO:000709810.015
regulation of protein complex assemblyGO:004325430.015
ear developmentGO:00435831270.015
phosphorus metabolic processGO:00067931090.015
regulation of response to extracellular stimulusGO:003210410.015
negative regulation of protein serine threonine kinase activityGO:007190120.015
thermosensory behaviorGO:004004010.015
regulation of apoptotic processGO:0042981980.015
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.015
germ cell developmentGO:0007281220.015
Worm
regulation of mrna splicing via spliceosomeGO:004802430.015
regulation of cytokine productionGO:000181730.015
actin filament based processGO:0030029640.015
convergent extension involved in gastrulationGO:0060027710.015
protein phosphorylationGO:0006468470.014
embryonic skeletal system morphogenesisGO:0048704930.014
sensory organ developmentGO:00074233930.014
female gamete generationGO:0007292140.014
Worm
negative regulation of mitosisGO:004583930.014
regulation of programmed cell deathGO:00430671010.014
nuclear migrationGO:000709730.014
regulation of molecular functionGO:0065009700.014
cell cell signalingGO:0007267520.014
regulation of autophagyGO:001050630.014
regulation of neurological system processGO:003164420.014
response to bacteriumGO:0009617580.014
regulation of response to nutrient levelsGO:003210710.014
regulation of epithelial cell proliferationGO:005067830.014
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.014
small molecule metabolic processGO:0044281770.014
regulation of nervous system developmentGO:0051960900.014
negative regulation of epithelial cell proliferationGO:005068010.014
specification of organ identityGO:001009220.014
stem cell differentiationGO:00488631170.013
spermatid developmentGO:000728620.013
positive regulation of stem cell proliferationGO:200064810.013
defense responseGO:0006952470.013
cellular response to organic substanceGO:00713101050.013
negative regulation of cell differentiationGO:0045596460.013
response to growth factorGO:0070848390.013
liver developmentGO:0001889960.013
positive regulation of histone modificationGO:003105810.013
membrane invaginationGO:001032410.013
ameboidal type cell migrationGO:00016671430.013
organic cyclic compound biosynthetic processGO:19013622230.013
transcription elongation from rna polymerase ii promoterGO:000636830.013
positive regulation of jnk cascadeGO:004633030.013
response to virusGO:0009615210.013
somite developmentGO:0061053960.013
cortical cytoskeleton organizationGO:003086510.013
organelle assemblyGO:00709251100.013
embryonic cranial skeleton morphogenesisGO:0048701900.013
segmentationGO:0035282970.013
transmembrane transportGO:00550851200.012
negative regulation of catabolic processGO:000989530.012
positive regulation of developmental processGO:0051094500.012
macromolecular complex assemblyGO:0065003350.012
regulation of establishment of planar polarityGO:009017540.012
gastrulationGO:00073692080.012
rna 3 end processingGO:003112320.012
response to oxygen containing compoundGO:1901700550.012
Mouse
canonical wnt signaling pathwayGO:0060070480.012
single organism behaviorGO:0044708240.012
regulation of transportGO:0051049450.012
Fly
negative regulation of cell migrationGO:0030336170.012
negative regulation of multi organism processGO:004390130.012
cellular response to endogenous stimulusGO:0071495680.012
myeloid cell homeostasisGO:0002262560.012
protein polyubiquitinationGO:000020940.012
production of molecular mediator of immune responseGO:000244020.012
regulation of locomotionGO:0040012550.012
homeostasis of number of cellsGO:0048872620.011
extrinsic apoptotic signaling pathwayGO:009719130.011
endocytosisGO:0006897160.011
cell cycle arrestGO:000705010.011
central nervous system developmentGO:00074173870.011
negative regulation of chromosome organizationGO:200125110.011
spermatid differentiationGO:004851520.011
establishment of organelle localizationGO:0051656450.011
response to nutrientGO:000758430.011
defense response to virusGO:0051607100.011
ion homeostasisGO:0050801410.011
agingGO:000756820.011
cell activationGO:0001775160.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.011
periodic partitioningGO:000736510.011
embryonic viscerocranium morphogenesisGO:0048703520.011
regulation of oocyte developmentGO:006028130.011
positive regulation of cell activationGO:005086710.011
optic placode formationGO:000174340.011
intracellular estrogen receptor signaling pathwayGO:003052030.011
negative regulation of cytoplasmic transportGO:190365020.011
regulation of protein transportGO:005122330.011
Fly
regulation of anatomical structure morphogenesisGO:00226031300.011
negative regulation of cell motilityGO:2000146170.011
b cell activationGO:004211320.011
organism emergence from protective structureGO:007168440.011
peptidyl lysine acetylationGO:001839420.010
negative regulation of intracellular signal transductionGO:1902532220.010
mrna processingGO:0006397140.010
endosome to lysosome transportGO:000833310.010
protein stabilizationGO:005082120.010
erythrocyte homeostasisGO:0034101550.010
locomotor rhythmGO:004547530.010
regulation of cell sizeGO:0008361290.010
glomerular visceral epithelial cell fate commitmentGO:007214940.010
spliceosomal snrnp assemblyGO:000038720.010
germ line stem cell maintenanceGO:003071820.010
convergent extension involved in organogenesisGO:0060029100.010
negative regulation of cellular component movementGO:0051271180.010
positive regulation of rna biosynthetic processGO:1902680570.010
positive regulation of epithelial cell migrationGO:001063420.010
single organism reproductive processGO:0044702400.010
Worm

kpna4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.392
nervous system diseaseDOID:86300.059
organ system cancerDOID:005068600.042
cancerDOID:16200.042
disease of cellular proliferationDOID:1456600.042
musculoskeletal system diseaseDOID:1700.032
muscle tissue diseaseDOID:6600.026
myopathyDOID:42300.026
muscular diseaseDOID:008000000.026
cardiomyopathyDOID:005070000.016
cardiovascular system diseaseDOID:128700.016
intrinsic cardiomyopathyDOID:006003600.016
heart diseaseDOID:11400.016
central nervous system diseaseDOID:33100.014
neurodegenerative diseaseDOID:128900.014
synucleinopathyDOID:005089000.011