Danio rerio

0 known processes

sigirr

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

(Aliases: sc:d148)

sigirr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.080
positive regulation of transportGO:005105020.053
maintenance of locationGO:005123540.052
agingGO:000756820.047
cellular macromolecule metabolic processGO:00442603910.046
Human
cellular aromatic compound metabolic processGO:00067252950.045
Human
biosynthetic processGO:00090582940.045
Human
central nervous system developmentGO:00074173870.044
response to chemicalGO:00422213200.043
organic cyclic compound metabolic processGO:19013603010.042
Human
negative regulation of biological processGO:00485193040.041
Human
signal transductionGO:00071654550.040
regulation of biological qualityGO:00650082630.040
autophagyGO:000691440.040
single organism metabolic processGO:00447102170.038
cell migrationGO:00164772370.037
nitrogen compound metabolic processGO:00068073190.036
Human
gtp catabolic processGO:000618420.036
lipid storageGO:001991510.036
response to drugGO:004249330.035
cellular component movementGO:00069283350.035
regulation of establishment of protein localizationGO:007020140.035
i kappab kinase nf kappab signalingGO:000724940.035
regulation of reproductive processGO:200024140.035
heterocycle metabolic processGO:00464832900.035
Human
response to stressGO:00069502630.035
cellular nitrogen compound biosynthetic processGO:00442712180.034
Human
multicellular organism growthGO:003526440.034
morphogenesis of an epitheliumGO:00020093330.033
positive regulation of catabolic processGO:000989640.032
regulation of nucleoside metabolic processGO:000911820.032
organic substance biosynthetic processGO:19015762890.032
Human
small molecule metabolic processGO:0044281770.031
localization of cellGO:00516742440.031
single fertilizationGO:000733830.030
adult behaviorGO:003053420.030
gene expressionGO:00104672520.030
Human
regulation of cytokine productionGO:000181730.029
cognitionGO:005089010.029
single organism organelle organizationGO:19025891990.029
exocytosisGO:000688710.029
ameboidal type cell migrationGO:00016671430.028
positive regulation of cellular catabolic processGO:003133130.028
meiotic cell cycle processGO:190304630.028
regulation of gene expressionGO:00104682650.028
Human
regulation of protein transportGO:005122330.028
regulation of multicellular organismal developmentGO:20000262230.027
heart developmentGO:00075073130.027
proteolysis involved in cellular protein catabolic processGO:005160330.027
regulation of cellular metabolic processGO:00313233200.027
Human
cellular nitrogen compound metabolic processGO:00346412900.027
Human
embryonic organ developmentGO:00485683810.027
meiotic nuclear divisionGO:000712640.027
stem cell proliferationGO:007208940.027
regulation of primary metabolic processGO:00800903110.027
Human
fertilizationGO:000956630.027
transportGO:00068102200.027
regulation of nucleotide catabolic processGO:003081120.026
cell surface receptor signaling pathwayGO:00071663250.026
cellular biosynthetic processGO:00442492860.026
Human
rna metabolic processGO:00160702190.026
Human
generation of neuronsGO:00486993850.026
positive regulation of biological processGO:00485182530.025
membrane fusionGO:006102520.025
cellular component disassemblyGO:002241110.025
head developmentGO:00603223030.024
cellular response to external stimulusGO:007149620.024
system processGO:00030081850.024
gtp metabolic processGO:004603940.024
regulation of multicellular organism growthGO:004001440.024
nucleobase containing compound metabolic processGO:00061392740.024
Human
guanosine containing compound metabolic processGO:190106840.023
cellular protein catabolic processGO:004425740.023
regulation of i kappab kinase nf kappab signalingGO:004312240.023
organelle fusionGO:004828430.023
cellular response to chemical stimulusGO:00708871570.023
immune system processGO:00023762410.023
regulation of synapse organizationGO:005080730.023
nucleic acid metabolic processGO:00903042440.023
Human
positive regulation of purine nucleotide catabolic processGO:003312310.023
cellular response to oxygen levelsGO:007145310.022
organonitrogen compound metabolic processGO:1901564740.022
cell motilityGO:00488702440.022
growthGO:00400071740.022
regulation of metabolic processGO:00192223590.022
Human
brain developmentGO:00074202930.022
embryonic organ morphogenesisGO:00485622740.022
organic cyclic compound biosynthetic processGO:19013622230.022
Human
guanosine containing compound catabolic processGO:190106920.022
regulation of nitrogen compound metabolic processGO:00511712510.022
Human
carboxylic acid catabolic processGO:004639530.022
cell deathGO:00082191210.022
nuclear migrationGO:000709730.022
regulation of tube sizeGO:003515020.021
nucleic acid templated transcriptionGO:00976591810.021
Human
rna biosynthetic processGO:00327741810.021
Human
organic acid metabolic processGO:0006082310.021
cellular response to decreased oxygen levelsGO:003629410.021
amine metabolic processGO:000930820.021
modification dependent macromolecule catabolic processGO:004363230.021
regulation of multicellular organismal processGO:00512392770.021
carboxylic acid metabolic processGO:0019752220.021
oocyte anterior posterior axis specificationGO:000731440.021
single organism membrane fusionGO:004480120.020
negative regulation of cellular processGO:00485232830.020
homeostatic processGO:00425921420.020
cellular ketone metabolic processGO:0042180110.020
regulation of developmental processGO:00507932470.020
mitochondrion organizationGO:000700540.020
positive regulation of cytokine productionGO:000181920.020
oxoacid metabolic processGO:0043436310.020
single organism localizationGO:19025782250.020
regulation of cytoplasmic transportGO:190364940.020
regulation of macromolecule metabolic processGO:00602553170.020
Human
heterocycle biosynthetic processGO:00181302150.020
Human
chordate embryonic developmentGO:00430092710.020
neuroblast proliferationGO:000740520.020
regulation of intracellular protein transportGO:003315730.020
response to external stimulusGO:00096052640.020
actin polymerization or depolymerizationGO:000815420.020
establishment of localizationGO:00512342440.020
cellular component assemblyGO:00226071700.020
modification dependent protein catabolic processGO:001994130.020
tube morphogenesisGO:00352393490.020
synaptic growth at neuromuscular junctionGO:005112420.020
cellular component morphogenesisGO:00329893360.019
regulation of purine nucleotide catabolic processGO:003312120.019
ubiquitin dependent protein catabolic processGO:000651130.019
positive regulation of i kappab kinase nf kappab signalingGO:004312330.019
regulation of synapse assemblyGO:005196330.019
regulation of signal transductionGO:00099662250.019
nucleobase containing compound biosynthetic processGO:00346542050.018
Human
regulation of protein catabolic processGO:004217610.018
deathGO:00162651210.018
embryo development ending in birth or egg hatchingGO:00097922710.018
cellular component biogenesisGO:00440851780.018
digestive tract developmentGO:00485652650.018
positive regulation of cellular component biogenesisGO:004408930.018
embryonic heart tube developmentGO:00350501330.018
compound eye developmentGO:004874920.018
positive regulation of nucleoside metabolic processGO:004597910.018
positive regulation of cell cycleGO:004578730.018
hemopoiesisGO:00300971830.018
response to monosaccharideGO:003428430.018
regulation of gtpase activityGO:004308720.018
digestive system developmentGO:00551232890.018
digestive tract morphogenesisGO:00485462310.018
regulation of macromolecule biosynthetic processGO:00105562250.018
Human
organelle organizationGO:00069962270.017
single organism transportGO:00447652060.017
proteasomal protein catabolic processGO:001049820.017
cellular amine metabolic processGO:004410620.017
spermatid developmentGO:000728620.017
rna localizationGO:000640340.017
cellular response to extracellular stimulusGO:003166820.017
regulation of signalingGO:00230512350.017
regulation of cellular biosynthetic processGO:00313262450.017
Human
response to nutrientGO:000758430.017
aromatic compound biosynthetic processGO:00194382170.017
Human
dorsal motor nucleus of vagus nerve developmentGO:002174440.017
positive regulation of cytosolic calcium ion concentrationGO:000720440.017
positive regulation of secretionGO:005104710.017
negative regulation of protein phosphorylationGO:000193340.017
intracellular signal transductionGO:0035556850.017
cellular amino acid metabolic processGO:000652070.017
apoptotic processGO:00069151160.017
peptide transportGO:001583310.017
stem cell maintenanceGO:001982740.017
regulation of synaptic plasticityGO:004816710.017
dorsal ventral pattern formationGO:00099531250.017
epithelial tube morphogenesisGO:00605621480.017
sensory organ developmentGO:00074233930.016
muscle structure developmentGO:00610611960.016
chemosensory behaviorGO:000763510.016
extrinsic apoptotic signaling pathwayGO:009719130.016
developmental growthGO:00485891660.016
positive regulation of secretion by cellGO:190353210.016
neuron developmentGO:00486662620.016
cellular response to hypoxiaGO:007145610.016
regulation of rna metabolic processGO:00512522240.016
Human
spermatid differentiationGO:004851520.016
symbiosis encompassing mutualism through parasitismGO:004440340.016
response to carbohydrateGO:000974330.016
monoamine transportGO:001584410.016
nuclear transportGO:005116940.016
cell projection organizationGO:00300302840.016
g protein coupled receptor signaling pathwayGO:0007186740.016
response to hexoseGO:000974630.016
protein import into nucleusGO:000660630.016
eye developmentGO:00016542770.016
transcription dna templatedGO:00063511810.016
Human
regulation of muscle contractionGO:000693730.015
meiosis iGO:000712710.015
protein localization to plasma membraneGO:007265910.015
maternal determination of anterior posterior axis embryoGO:000835840.015
cellular response to nutrient levelsGO:003166920.015
regulation of cell deathGO:00109411030.015
protein localization to nucleusGO:003450430.015
nucleocytoplasmic transportGO:000691340.015
positive regulation of immune effector processGO:000269930.015
cell part morphogenesisGO:00329902460.015
protein metabolic processGO:00195381830.015
positive regulation of blood circulationGO:190352420.015
regulation of biosynthetic processGO:00098892500.015
Human
ion transportGO:00068111140.015
regulation of cellular ketone metabolic processGO:001056570.015
regulation of response to stimulusGO:00485832690.015
protein targeting to nucleusGO:004474430.015
protein complex disassemblyGO:004324110.015
lipid homeostasisGO:005508830.015
regulation of bindingGO:005109830.015
purine ribonucleoside monophosphate catabolic processGO:000916940.015
neuron neuron synaptic transmissionGO:000727010.015
positive regulation of cell activationGO:005086710.015
cell morphogenesisGO:00009022890.015
cytoplasm organizationGO:000702840.015
antimicrobial humoral responseGO:001973020.015
positive regulation of gtpase activityGO:004354710.014
g1 s transition of mitotic cell cycleGO:000008210.014
regulation of nucleocytoplasmic transportGO:004682220.014
regulation of cell communicationGO:00106462320.014
regulation of cell activationGO:005086510.014
regulation of protein localization to nucleusGO:190018020.014
regulation of blood pressureGO:000821710.014
regulation of rna biosynthetic processGO:20011412130.014
Human
cellular localizationGO:0051641970.014
neuron differentiationGO:00301823530.014
regulation of metal ion transportGO:001095940.014
glial cell migrationGO:000834730.014
cytokinesisGO:000091030.014
regulation of cellular amine metabolic processGO:003323800.014
endosomal transportGO:001619720.014
determination of left right symmetryGO:00073681790.014
specification of symmetryGO:00097992040.014
protein importGO:001703830.014
regulation of dendrite developmentGO:005077330.014
neuron projection developmentGO:00311751800.014
establishment of protein localization to organelleGO:007259440.014
macromolecule biosynthetic processGO:00090592270.014
Human
muscle cell developmentGO:00550011150.014
adherens junction organizationGO:003433240.014
small molecule catabolic processGO:004428230.014
regulation of blood vessel sizeGO:005088020.014
positive regulation of gtp catabolic processGO:003312610.014
positive regulation of nucleotide catabolic processGO:003081310.014
blood vessel developmentGO:00015682460.014
regulation of nucleobase containing compound metabolic processGO:00192192500.014
Human
dna templated transcription elongationGO:000635430.014
stem cell divisionGO:001714510.014
positive regulation of cellular processGO:00485222010.014
single organism nuclear importGO:190259330.014
leukocyte proliferationGO:007066110.014
regulation of transcription elongation from rna polymerase ii promoterGO:003424330.014
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.014
regulation of cell differentiationGO:00455951420.014
cellular protein metabolic processGO:00442671290.014
multi organism cellular processGO:004476420.014
regulation of transcription from rna polymerase ii promoterGO:00063571140.014
medulla oblongata developmentGO:002155040.014
positive regulation of cytoskeleton organizationGO:005149530.013
muscle organ developmentGO:00075171010.013
secondary metabolic processGO:001974830.013
interspecies interaction between organismsGO:004441940.013
neurotransmitter transportGO:000683620.013
regulation of protein targetingGO:190353320.013
macromolecule modificationGO:00434121110.013
regulation of gtp catabolic processGO:003312420.013
negative regulation of mapk cascadeGO:004340940.013
cell proliferationGO:0008283800.013
cation transportGO:0006812810.013
macromolecular complex disassemblyGO:003298410.013
negative regulation of signalingGO:0023057960.013
striated muscle cell differentiationGO:00511461290.013
regulation of protein import into nucleusGO:004230620.013
regulation of autophagyGO:001050630.013
response to glucocorticoidGO:005138410.013
response to corticosteroidGO:003196010.013
phagocytosisGO:000690930.013
cellular lipid catabolic processGO:004424230.013
cellular response to organic substanceGO:00713101050.013
regionalizationGO:00030022740.013
protein secretionGO:000930610.013
regulation of mrna processingGO:005068430.013
blood vessel morphogenesisGO:00485142160.013
cellular component assembly involved in morphogenesisGO:00109271070.013
camera type eye developmentGO:00430102220.013
regulation of programmed cell deathGO:00430671010.013
cellular macromolecule biosynthetic processGO:00346452240.013
Human
nucleoside monophosphate catabolic processGO:000912540.013
vasculature developmentGO:00019442780.013
immune system developmentGO:00025201910.012
response to alkaloidGO:004327920.012
cell projection morphogenesisGO:00488582440.012
protein polymerizationGO:005125840.012
phosphate containing compound metabolic processGO:00067961080.012
regulation of protein complex assemblyGO:004325430.012
cytoskeleton organizationGO:0007010960.012
protein complex localizationGO:003150310.012
ribonucleoside monophosphate catabolic processGO:000915840.012
angiogenesisGO:00015251580.012
negative regulation of reproductive processGO:200024230.012
hematopoietic or lymphoid organ developmentGO:00485341910.012
apoptotic process involved in morphogenesisGO:006056120.012
eye morphogenesisGO:00485921440.012
negative regulation of protein transportGO:005122430.012
positive regulation of cell adhesionGO:004578510.012
negative regulation of cytokine productionGO:000181810.012
locomotionGO:00400113130.012
regulation of neurotransmitter transportGO:005158810.012
regulation of oocyte developmentGO:006028130.012
regulation of response to biotic stimulusGO:000283120.012
positive regulation of protein complex assemblyGO:003133420.012
regulation of cellular amino acid metabolic processGO:000652100.012
negative regulation of catabolic processGO:000989530.012
retina development in camera type eyeGO:00600411460.012
synaptic vesicle localizationGO:009747910.012
muscle cell differentiationGO:00426921390.012
organelle assemblyGO:00709251100.012
regulation of protein polymerizationGO:003227120.012
anterior posterior pattern specificationGO:00099521520.012
establishment of protein localization to plasma membraneGO:009000210.011
response to uvGO:000941130.011
response to woundingGO:00096111160.011
negative regulation of map kinase activityGO:004340720.011
nuclear importGO:005117030.011
intracellular mrna localizationGO:000829810.011
myeloid cell differentiationGO:0030099860.011
organic acid catabolic processGO:001605430.011
response to glucoseGO:000974930.011
rna 3 end processingGO:003112320.011
cytoskeleton dependent cytokinesisGO:006164030.011
phagocytosis engulfmentGO:000691110.011
negative regulation of protein serine threonine kinase activityGO:007190120.011
regulation of synaptic growth at neuromuscular junctionGO:000858210.011
regulation of ion transmembrane transporter activityGO:003241220.011
response to transition metal nanoparticleGO:1990267280.011
mononuclear cell proliferationGO:003294310.011
regulation of localizationGO:00328791040.011
negative regulation of protein kinase activityGO:000646940.011
membrane invaginationGO:001032410.011
response to other organismGO:0051707970.011
germ line stem cell maintenanceGO:003071820.011
phosphatidylinositol 3 kinase signalingGO:001406520.011
positive regulation of cellular amine metabolic processGO:003324000.011
atp catabolic processGO:000620040.011
programmed cell deathGO:00125011190.011
striated muscle cell developmentGO:00550021080.011
developmental programmed cell deathGO:001062340.011
negative regulation of cell deathGO:0060548600.011
response to vitaminGO:003327330.011
regulation of cell shapeGO:000836010.011
multi organism processGO:00517041340.010
regulation of nucleic acid templated transcriptionGO:19035062130.010
Human
protein polyubiquitinationGO:000020940.010
regulation of fatty acid metabolic processGO:001921710.010
regulation of cell projection assemblyGO:006049140.010
regulation of filopodium assemblyGO:005148920.010
lymphocyte proliferationGO:004665110.010
production of molecular mediator of immune responseGO:000244020.010
female meiotic divisionGO:000714320.010
cellular response to starvationGO:000926710.010
cell junction maintenanceGO:003433120.010
skeletal system developmentGO:00015011810.010
alpha amino acid metabolic processGO:190160530.010
regulation of protein localization to plasma membraneGO:190307610.010
viral processGO:001603210.010
catechol containing compound metabolic processGO:000971220.010
negative regulation of multi organism processGO:004390130.010
gastrulationGO:00073692080.010
positive regulation of cellular amino acid metabolic processGO:004576400.010
peptide metabolic processGO:000651810.010
determination of bilateral symmetryGO:00098552040.010
response to biotic stimulusGO:0009607970.010
neurological system processGO:0050877620.010
regulation of peptidyl tyrosine phosphorylationGO:005073010.010

sigirr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.048
musculoskeletal system diseaseDOID:1700.020
immune system diseaseDOID:291400.016
nervous system diseaseDOID:86300.014
disease of cellular proliferationDOID:1456600.013
cancerDOID:16200.013
organ system cancerDOID:005068600.013
muscular diseaseDOID:008000000.012
muscle tissue diseaseDOID:6600.012
disease of metabolismDOID:001466700.011
cardiovascular system diseaseDOID:128700.011