Danio rerio

0 known processes

phlda2

pleckstrin homology-like domain, family A, member 2

(Aliases: zgc:110459,MGC110459)

phlda2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nitrogen compound metabolic processGO:00068073190.223
cellular response to lipopolysaccharideGO:007122230.185
establishment of protein localization to plasma membraneGO:009000210.179
regulation of establishment of protein localizationGO:007020140.176
protein import into nucleusGO:000660630.169
single organism nuclear importGO:190259330.141
positive regulation of cell deathGO:0010942290.137
regulation of nucleotide catabolic processGO:003081120.133
chordate embryonic developmentGO:00430092710.126
nuclear transportGO:005116940.124
heart contractionGO:0060047710.121
regulation of bindingGO:005109830.120
protein importGO:001703830.112
notochord developmentGO:0030903540.109
regulation of protein localization to nucleusGO:190018020.107
nuclear importGO:005117030.105
apoptotic processGO:00069151160.103
single organism metabolic processGO:00447102170.102
Mouse
negative regulation of protein phosphorylationGO:000193340.100
protein targeting to nucleusGO:004474430.098
positive regulation of blood circulationGO:190352420.098
regulation of protein import into nucleusGO:004230620.096
establishment of protein localization to organelleGO:007259440.096
nucleocytoplasmic transportGO:000691340.095
response to drugGO:004249330.094
protein localization to plasma membraneGO:007265910.093
cellular biosynthetic processGO:00442492860.087
cell migrationGO:00164772370.081
Mouse
response to chemicalGO:00422213200.076
cellular aromatic compound metabolic processGO:00067252950.076
regulation of protein targetingGO:190353320.075
mitochondrion organizationGO:000700540.074
cell deathGO:00082191210.072
nucleic acid templated transcriptionGO:00976591810.070
positive regulation of purine nucleotide catabolic processGO:003312310.069
regulation of multicellular organismal processGO:00512392770.068
Mouse
negative regulation of biological processGO:00485193040.068
positive regulation of biological processGO:00485182530.067
regulation of nucleocytoplasmic transportGO:004682220.067
establishment of localizationGO:00512342440.063
nucleobase containing compound metabolic processGO:00061392740.062
heterocycle metabolic processGO:00464832900.062
eye developmentGO:00016542770.062
organic cyclic compound biosynthetic processGO:19013622230.062
cellular response to chemical stimulusGO:00708871570.062
protein localization to nucleusGO:003450430.060
response to stressGO:00069502630.060
regulation of biological qualityGO:00650082630.060
embryo development ending in birth or egg hatchingGO:00097922710.059
positive regulation of cellular catabolic processGO:003133130.058
negative regulation of protein transportGO:005122430.058
macromolecule modificationGO:00434121110.058
embryonic organ developmentGO:00485683810.058
phosphate containing compound metabolic processGO:00067961080.058
regulation of cysteine type endopeptidase activityGO:2000116210.058
multicellular organism growthGO:003526440.057
ventricular cardiac muscle tissue developmentGO:000322930.056
tissue regenerationGO:0042246740.056
system processGO:00030081850.055
regulation of reproductive processGO:200024140.055
cellular component movementGO:00069283350.055
Mouse
regulation of nitrogen compound metabolic processGO:00511712510.055
cellular response to biotic stimulusGO:007121630.055
purine ribonucleoside monophosphate catabolic processGO:000916940.053
nucleoside phosphate biosynthetic processGO:1901293210.052
nucleic acid metabolic processGO:00903042440.052
positive regulation of apoptotic processGO:0043065290.052
response to organic substanceGO:00100331530.051
myeloid leukocyte differentiationGO:0002573150.051
regulation of nucleobase containing compound metabolic processGO:00192192500.051
negative regulation of i kappab kinase nf kappab signalingGO:004312410.050
nucleoside monophosphate catabolic processGO:000912540.050
aromatic compound biosynthetic processGO:00194382170.050
positive regulation of programmed cell deathGO:0043068290.050
organonitrogen compound metabolic processGO:1901564740.049
head developmentGO:00603223030.048
brain developmentGO:00074202930.048
positive regulation of nucleoside metabolic processGO:004597910.047
nucleobase containing small molecule metabolic processGO:0055086320.044
single organism reproductive processGO:0044702400.044
Mouse
agingGO:000756820.044
adult behaviorGO:003053420.044
cellular component biogenesisGO:00440851780.044
single fertilizationGO:000733830.043
myeloid cell differentiationGO:0030099860.043
immune system developmentGO:00025201910.043
fertilizationGO:000956630.042
positive regulation of gtpase activityGO:004354710.042
negative regulation of signalingGO:0023057960.042
membrane raft organizationGO:003157910.041
positive regulation of catabolic processGO:000989640.041
cellular component assembly involved in morphogenesisGO:00109271070.041
regulation of developmental processGO:00507932470.041
Mouse
heterocycle biosynthetic processGO:00181302150.041
regulation of intracellular protein transportGO:003315730.040
negative regulation of gene expressionGO:0010629650.040
macromolecule biosynthetic processGO:00090592270.040
multi organism cellular processGO:004476420.040
purine nucleoside monophosphate catabolic processGO:000912840.039
regulation of macromolecule metabolic processGO:00602553170.039
Mouse
spermatid developmentGO:000728620.039
regulation of programmed cell deathGO:00430671010.039
viral processGO:001603210.039
purine nucleotide metabolic processGO:0006163270.039
regulation of endopeptidase activityGO:0052548230.038
regulation of signalingGO:00230512350.038
small molecule metabolic processGO:0044281770.037
cellular macromolecule metabolic processGO:00442603910.037
Mouse
negative regulation of protein localization to nucleusGO:190018120.037
regulation of cell deathGO:00109411030.037
regulation of protein transportGO:005122330.037
regulation of response to oxidative stressGO:190288220.037
response to inorganic substanceGO:0010035380.036
regulation of nucleoside metabolic processGO:000911820.036
organic cyclic compound metabolic processGO:19013603010.036
regulation of gene expressionGO:00104682650.036
Mouse
regulation of myotube differentiationGO:001083020.036
blood vessel morphogenesisGO:00485142160.035
i kappab kinase nf kappab signalingGO:000724940.035
regulation of rna biosynthetic processGO:20011412130.035
negative regulation of apoptotic processGO:0043066550.034
epithelial cell differentiationGO:00308551160.034
sensory organ developmentGO:00074233930.034
positive regulation of myeloid cell differentiationGO:004563920.034
symbiosis encompassing mutualism through parasitismGO:004440340.034
transcription dna templatedGO:00063511810.034
heart processGO:0003015710.034
gene expressionGO:00104672520.034
Mouse
cell surface receptor signaling pathwayGO:00071663250.034
regulation of transcription dna templatedGO:00063552130.034
regulation of response to biotic stimulusGO:000283120.033
positive regulation of gtp catabolic processGO:003312610.033
positive regulation of endothelial cell proliferationGO:000193810.033
positive regulation of cellular processGO:00485222010.033
programmed cell deathGO:00125011190.032
regulation of gtp catabolic processGO:003312420.032
response to external stimulusGO:00096052640.032
cellular response to external stimulusGO:007149620.032
maintenance of locationGO:005123540.032
phosphorus metabolic processGO:00067931090.032
cellular process involved in reproduction in multicellular organismGO:0022412280.032
regulation of cellular macromolecule biosynthetic processGO:20001122220.031
tube morphogenesisGO:00352393490.031
single organism localizationGO:19025782250.031
meiotic nuclear divisionGO:000712640.031
glucose importGO:004632320.030
regulation of cytokine productionGO:000181730.030
adherens junction organizationGO:003433240.030
response to amino acidGO:004320020.030
mesenchyme developmentGO:00604851270.030
regulation of nucleic acid templated transcriptionGO:19035062130.030
positive regulation of nucleotide catabolic processGO:003081310.029
signal transductionGO:00071654550.029
mesenchymal cell differentiationGO:0048762870.029
regulation of i kappab kinase nf kappab signalingGO:004312240.029
cognitionGO:005089010.029
signal transduction by phosphorylationGO:0023014180.028
apoptotic signaling pathwayGO:0097190230.028
positive regulation of nitrogen compound metabolic processGO:0051173690.027
nucleobase containing compound biosynthetic processGO:00346542050.027
regulation of catalytic activityGO:0050790550.027
proteolysisGO:0006508380.027
regulation of cytoplasmic transportGO:190364940.027
positive regulation of purine nucleotide metabolic processGO:190054490.027
anterior posterior pattern specificationGO:00099521520.027
regenerationGO:0031099910.027
cellular response to molecule of bacterial originGO:007121930.027
multicellular organismal signalingGO:0035637220.026
organophosphate metabolic processGO:0019637370.026
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.026
cellular nitrogen compound metabolic processGO:00346412900.026
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.026
cell proliferationGO:0008283800.026
negative regulation of nucleocytoplasmic transportGO:004682320.026
interspecies interaction between organismsGO:004441940.026
intracellular transportGO:0046907320.026
regulation of stem cell proliferationGO:007209120.026
cellular response to organic substanceGO:00713101050.026
regulation of extrinsic apoptotic signaling pathwayGO:200123630.026
purine ribonucleotide metabolic processGO:0009150270.025
regulation of cell differentiationGO:00455951420.025
antimicrobial humoral responseGO:001973020.025
cellular macromolecule biosynthetic processGO:00346452240.025
cellular carbohydrate metabolic processGO:004426240.025
Mouse
positive regulation of metabolic processGO:00098931080.025
negative regulation of intracellular protein transportGO:009031730.025
positive regulation of transportGO:005105020.025
g2 m transition of mitotic cell cycleGO:000008640.025
response to methylmercuryGO:0051597110.025
cell cycle g2 m phase transitionGO:004483940.025
cellular nitrogen compound biosynthetic processGO:00442712180.025
negative regulation of metabolic processGO:0009892860.025
gtp catabolic processGO:000618420.024
osteoclast differentiationGO:003031610.024
cell motilityGO:00488702440.024
Mouse
heart morphogenesisGO:00030071560.024
protein localizationGO:0008104400.024
positive regulation of immune effector processGO:000269930.024
segmentationGO:0035282970.024
chemosensory behaviorGO:000763510.024
multi organism processGO:00517041340.023
regulation of gtpase activityGO:004308720.023
nucleotide biosynthetic processGO:0009165210.023
cellular component disassemblyGO:002241110.023
blood circulationGO:0008015870.023
cellular response to organic cyclic compoundGO:0071407380.023
proteasomal protein catabolic processGO:001049820.023
regulation of muscle contractionGO:000693730.023
intracellular signal transductionGO:0035556850.023
cell death in response to oxidative stressGO:003647320.022
ameboidal type cell migrationGO:00016671430.022
response to other organismGO:0051707970.022
regulation of multicellular organism growthGO:004001440.022
response to virusGO:0009615210.022
regulation of epithelial cell proliferationGO:005067830.022
developmental growthGO:00485891660.022
negative regulation of protein kinase b signalingGO:005189820.022
immune system processGO:00023762410.022
regulation of metabolic processGO:00192223590.022
Mouse
primitive erythrocyte differentiationGO:006031950.022
response to hydrogen peroxideGO:004254230.022
cellular localizationGO:0051641970.022
positive regulation of nucleobase containing compound metabolic processGO:0045935690.022
cellular protein metabolic processGO:00442671290.022
regulation of transmembrane transporter activityGO:002289820.021
embryonic skeletal system morphogenesisGO:0048704930.021
gtp metabolic processGO:004603940.021
growthGO:00400071740.021
digestive tract developmentGO:00485652650.021
atp catabolic processGO:000620040.021
cellular protein catabolic processGO:004425740.021
central nervous system developmentGO:00074173870.021
action potentialGO:0001508190.021
regulation of transcription from rna polymerase ii promoterGO:00063571140.021
ribonucleoside monophosphate catabolic processGO:000915840.021
regulation of erk1 and erk2 cascadeGO:007037240.021
rna biosynthetic processGO:00327741810.020
response to mechanical stimulusGO:0009612240.020
skeletal system developmentGO:00015011810.020
protein metabolic processGO:00195381830.020
cellular response to stressGO:0033554620.020
single organism cellular localizationGO:1902580460.020
germ cell developmentGO:0007281220.020
circulatory system processGO:0003013870.020
nucleoside phosphate metabolic processGO:0006753280.020
negative regulation of intracellular signal transductionGO:1902532220.020
purine containing compound metabolic processGO:0072521290.020
negative regulation of cellular processGO:00485232830.020
organelle organizationGO:00069962270.020
rna metabolic processGO:00160702190.019
ribonucleoside triphosphate biosynthetic processGO:000920120.019
heart developmentGO:00075073130.019
carbohydrate derivative metabolic processGO:1901135610.019
cellular component assemblyGO:00226071700.019
ventricular cardiac muscle tissue morphogenesisGO:005501020.019
organonitrogen compound biosynthetic processGO:1901566470.019
regulation of apoptotic processGO:0042981980.019
amide biosynthetic processGO:004360410.019
sexual reproductionGO:0019953360.019
extrinsic apoptotic signaling pathwayGO:009719130.019
response to transition metal nanoparticleGO:1990267280.019
convergent extensionGO:00600261180.019
reactive oxygen species metabolic processGO:007259360.019
negative regulation of protein kinase activityGO:000646940.019
positive regulation of response to stimulusGO:0048584800.018
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280100.018
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.018
regulation of hydrolase activityGO:0051336280.018
cellular amide metabolic processGO:004360340.018
spermatid differentiationGO:004851520.018
skeletal system morphogenesisGO:00487051020.018
cytosolic calcium ion transportGO:006040130.018
regulation of multicellular organismal developmentGO:20000262230.018
Mouse
regulation of phosphate metabolic processGO:0019220430.018
neuron projection regenerationGO:0031102160.018
positive regulation of cell cycleGO:004578730.018
positive regulation of jnk cascadeGO:004633030.018
cell adhesionGO:0007155400.018
endoderm developmentGO:0007492490.018
lipid storageGO:001991510.018
response to molecule of bacterial originGO:0002237140.018
modification dependent protein catabolic processGO:001994130.018
regulation of membrane potentialGO:0042391230.018
negative regulation of molecular functionGO:0044092230.017
single organism intracellular transportGO:1902582250.017
peptide transportGO:001583310.017
negative regulation of kinase activityGO:003367340.017
negative regulation of nitrogen compound metabolic processGO:0051172590.017
regulation of striated muscle contractionGO:000694220.017
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.017
ribonucleotide metabolic processGO:0009259270.017
positive regulation of stress activated mapk cascadeGO:003287430.017
locomotor rhythmGO:004547530.017
oocyte anterior posterior axis specificationGO:000731440.017
negative regulation of myeloid cell differentiationGO:004563810.017
positive regulation of catalytic activityGO:0043085250.017
erythrocyte homeostasisGO:0034101550.017
regulation of cellular metabolic processGO:00313233200.017
Mouse
regulation of localizationGO:00328791040.017
Mouse
regulation of heart contractionGO:0008016320.017
positive regulation of multi organism processGO:004390230.017
camera type eye developmentGO:00430102220.016
maternal determination of anterior posterior axis embryoGO:000835840.016
hematopoietic or lymphoid organ developmentGO:00485341910.016
negative regulation of intracellular transportGO:003238730.016
mapk cascadeGO:0000165180.016
rho protein signal transductionGO:000726650.016
positive regulation of neuron apoptotic processGO:004352510.016
positive regulation of hydrolase activityGO:0051345130.016
positive regulation of cellular component biogenesisGO:004408930.016
protein heterooligomerizationGO:005129110.016
regulation of dna templated transcription in response to stressGO:004362000.016
sleepGO:003043110.016
transmission of nerve impulseGO:0019226190.015
regulation of response to stressGO:0080134360.015
cellular response to extracellular stimulusGO:003166820.015
hemopoiesisGO:00300971830.015
larval developmentGO:000216420.015
biosynthetic processGO:00090582940.015
purine nucleotide biosynthetic processGO:0006164200.015
ribose phosphate metabolic processGO:0019693270.015
regulation of wound healingGO:006104120.015
response to carbohydrateGO:000974330.015
regulation of primary metabolic processGO:00800903110.015
Mouse
transcription from rna polymerase ii promoterGO:0006366800.015
positive regulation of heart contractionGO:004582320.015
single organism transportGO:00447652060.015
positive regulation of cytoskeleton organizationGO:005149530.015
regulation of cellular protein metabolic processGO:0032268520.015
purine containing compound biosynthetic processGO:0072522200.015
organic acid metabolic processGO:0006082310.015
multi organism reproductive processGO:0044703360.015
regulation of cellular biosynthetic processGO:00313262450.015
negative regulation of protein import into nucleusGO:004230820.014
carboxylic acid metabolic processGO:0019752220.014
response to woundingGO:00096111160.014
cellular component morphogenesisGO:00329893360.014
response to monosaccharideGO:003428430.014
carbohydrate derivative biosynthetic processGO:1901137430.014
multicellular organismal macromolecule metabolic processGO:004425920.014
regulation of blood pressureGO:000821710.014
regulation of biosynthetic processGO:00098892500.014
regulation of rho protein signal transductionGO:003502320.014
regulation of peptidase activityGO:0052547230.014
angiogenesisGO:00015251580.014
pole plasm assemblyGO:000731540.014
cellular response to unfolded proteinGO:003462020.014
regulation of protein localization to plasma membraneGO:190307610.014
cardiac myofibril assemblyGO:005500390.014
regulation of reactive oxygen species metabolic processGO:200037720.014
blood vessel developmentGO:00015682460.014
positive regulation of signal transductionGO:0009967560.014
fin regenerationGO:0031101510.014
regulation of skeletal muscle tissue developmentGO:004864140.014
regulation of signal transductionGO:00099662250.013
regulation of circadian rhythmGO:004275240.013
stem cell proliferationGO:007208940.013
negative regulation of cellular metabolic processGO:0031324770.013
regulation of cellular response to oxidative stressGO:190040720.013
somite developmentGO:0061053960.013
muscle tissue developmentGO:00605371100.013
positive regulation of myeloid leukocyte differentiationGO:000276310.013
negative regulation of cell differentiationGO:0045596460.013
compound eye developmentGO:004874920.013
positive regulation of dna metabolic processGO:005105410.013
phagocytosisGO:000690930.013
regulation of endothelial cell proliferationGO:000193610.013
single organism carbohydrate metabolic processGO:0044723120.013
Mouse
regulation of stem cell differentiationGO:200073640.013
cytoplasm organizationGO:000702840.013
lens fiber cell morphogenesisGO:007030930.013
single organism behaviorGO:0044708240.013
catabolic processGO:0009056320.013
proteolysis involved in cellular protein catabolic processGO:005160330.013
cytoplasmic pattern recognition receptor signaling pathwayGO:000275310.013
collagen metabolic processGO:003296320.013
negative regulation of programmed cell deathGO:0043069580.013
erk1 and erk2 cascadeGO:007037140.013
cell cycleGO:0007049930.012
g1 s transition of mitotic cell cycleGO:000008210.012
macromolecule localizationGO:0033036540.012
cellular sodium ion homeostasisGO:000688310.012
reactive nitrogen species metabolic processGO:200105700.012
deathGO:00162651210.012
single organismal cell cell adhesionGO:0016337290.012
positive regulation of neuron deathGO:190121610.012
mesoderm morphogenesisGO:0048332510.012
mesoderm formationGO:0001707430.012
cell morphogenesisGO:00009022890.012
single organism membrane fusionGO:004480120.012
rhythmic processGO:0048511210.012
regulation of purine nucleotide catabolic processGO:003312120.012
cellular response to oxidative stressGO:003459950.012
embryonic hemopoiesisGO:0035162530.012
cranial nerve developmentGO:0021545420.012
muscle organ developmentGO:00075171010.012
outflow tract morphogenesisGO:000315110.012
lamellipodium organizationGO:009758110.012
positive regulation of developmental processGO:0051094500.012
actin cytoskeleton organizationGO:0030036630.012
monocyte differentiationGO:003022420.012
organic substance biosynthetic processGO:19015762890.011
regulation of response to stimulusGO:00485832690.011
small gtpase mediated signal transductionGO:000726480.011
single organism cell adhesionGO:0098602290.011
cellular macromolecule localizationGO:0070727210.011
positive regulation of ras gtpase activityGO:003232010.011
oxidation reduction processGO:0055114410.011
Mouse
response to hexoseGO:000974630.011
regulation of neural precursor cell proliferationGO:200017730.011
ubiquitin dependent protein catabolic processGO:000651130.011
response to nitrogen compoundGO:1901698190.011
regulation of ras gtpase activityGO:003231820.011
response to cadmium ionGO:0046686140.011
guanosine containing compound metabolic processGO:190106840.011
cellular amine metabolic processGO:004410620.011
regulation of protein metabolic processGO:0051246560.011
cellular protein localizationGO:0034613200.011
cellular protein modification processGO:00064641000.011
negative regulation of multi organism processGO:004390130.011
regulation of macromolecule biosynthetic processGO:00105562250.011
negative regulation of mitosisGO:004583930.011
response to external biotic stimulusGO:0043207970.011
regulation of phosphorylationGO:0042325260.011
phosphorylationGO:0016310690.011
positive regulation of molecular functionGO:0044093330.011
somitogenesisGO:0001756870.011
regulation of calcium ion transportGO:005192420.011
response to abiotic stimulusGO:00096281220.011
erythrocyte differentiationGO:0030218540.011
multicellular organismal reproductive processGO:0048609350.011
regulation of blood vessel sizeGO:005088020.011
neuroblast proliferationGO:000740520.011
cytokinesisGO:000091030.011
negative regulation of wound healingGO:006104510.011
vasculature developmentGO:00019442780.011
embryonic cranial skeleton morphogenesisGO:0048701900.011
positive regulation of peptidase activityGO:0010952100.010
positive regulation of macromolecule metabolic processGO:0010604930.010
muscle structure developmentGO:00610611960.010
regulation of intracellular signal transductionGO:1902531570.010
response to oxygen containing compoundGO:1901700550.010
regulation of organ morphogenesisGO:2000027350.010
organic substance transportGO:0071702580.010
response to organic cyclic compoundGO:0014070510.010
mitochondrial transportGO:000683920.010
positive regulation of apoptotic signaling pathwayGO:200123510.010
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.010
regulation of p38mapk cascadeGO:190074410.010
regulation of cell maturationGO:190342910.010
keratinocyte differentiationGO:003021600.010
water homeostasisGO:003010440.010
positive regulation of signalingGO:0023056560.010
reproductive processGO:0022414400.010
Mouse
biological adhesionGO:0022610400.010
defense response to fungusGO:005083220.010
regulation of anatomical structure morphogenesisGO:00226031300.010
regulation of molecular functionGO:0065009700.010
wound healingGO:0042060900.010
response to topologically incorrect proteinGO:003596620.010

phlda2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.097
nervous system diseaseDOID:86300.036
musculoskeletal system diseaseDOID:1700.033
muscular diseaseDOID:008000000.033
cardiovascular system diseaseDOID:128700.029
muscle tissue diseaseDOID:6600.029
intrinsic cardiomyopathyDOID:006003600.029
cardiomyopathyDOID:005070000.029
heart diseaseDOID:11400.029
myopathyDOID:42300.029
cancerDOID:16200.013
disease of cellular proliferationDOID:1456600.013