Danio rerio

16 known processes

lepr

leptin receptor

(Aliases: obr)

lepr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of biological processGO:00485182530.853
transmembrane transportGO:00550851200.758
system processGO:00030081850.673
generation of neuronsGO:00486993850.647
synaptic transmissionGO:0007268350.645
steroid hormone mediated signaling pathwayGO:004340190.596
striated muscle cell developmentGO:00550021080.595
embryonic organ developmentGO:00485683810.590
amino acid transportGO:000686520.562
embryonic organ morphogenesisGO:00485622740.420
metal ion transportGO:0030001580.418
response to chemicalGO:00422213200.418
ion transmembrane transportGO:0034220910.409
stem cell proliferationGO:007208940.403
ion transportGO:00068111140.403
heart loopingGO:0001947940.392
regulation of cell communicationGO:00106462320.380
cellular response to organic cyclic compoundGO:0071407380.344
skeletal system developmentGO:00015011810.338
regulation of synaptic plasticityGO:004816710.322
neuron developmentGO:00486662620.317
neuron neuron synaptic transmissionGO:000727010.313
signal transductionGO:00071654550.278
negative regulation of reproductive processGO:200024230.273
cation transmembrane transportGO:0098655650.270
cytosolic calcium ion transportGO:006040130.269
calcium ion transport into cytosolGO:006040230.258
regulation of metabolic processGO:00192223590.235
Mouse
cell cell signalingGO:0007267520.218
cell projection morphogenesisGO:00488582440.213
embryo development ending in birth or egg hatchingGO:00097922710.213
cell surface receptor signaling pathwayGO:00071663250.191
neuron differentiationGO:00301823530.184
cellular component morphogenesisGO:00329893360.183
oocyte maturationGO:000155640.183
single organism transportGO:00447652060.183
positive regulation of signal transductionGO:0009967560.180
biosynthetic processGO:00090582940.176
Mouse
neural crest cell differentiationGO:0014033720.174
neurological system processGO:0050877620.173
nitrogen compound metabolic processGO:00068073190.173
gene expressionGO:00104672520.165
cellular ketone metabolic processGO:0042180110.165
Mouse
embryonic skeletal joint developmentGO:007249830.156
striated muscle cell differentiationGO:00511461290.156
maintenance of locationGO:005123540.156
positive regulation of cellular component biogenesisGO:004408930.155
cellular component biogenesisGO:00440851780.153
cellular response to estrogen stimulusGO:0071391240.150
cellular response to estradiol stimulusGO:007139210.146
calcium ion homeostasisGO:0055074190.145
multi organism processGO:00517041340.143
organic substance biosynthetic processGO:19015762890.137
Mouse
sensory perception of chemical stimulusGO:000760630.134
cellular component assemblyGO:00226071700.134
regulation of blood pressureGO:000821710.134
amine metabolic processGO:000930820.132
negative regulation of multicellular organismal processGO:0051241690.130
response to organic substanceGO:00100331530.128
single organism metabolic processGO:00447102170.127
Mouse
regulation of calcium ion transportGO:005192420.126
intracellular signal transductionGO:0035556850.125
cell death in response to oxidative stressGO:003647320.122
regulation of signal transductionGO:00099662250.122
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217620.112
regulation of reproductive processGO:200024140.111
regulation of localizationGO:00328791040.109
cation transportGO:0006812810.109
directional locomotionGO:003305810.109
response to external stimulusGO:00096052640.108
regulation of locomotionGO:0040012550.107
positive regulation of cellular processGO:00485222010.103
embryonic cranial skeleton morphogenesisGO:0048701900.103
neuron projection developmentGO:00311751800.103
organic cyclic compound metabolic processGO:19013603010.099
Mouse
regulation of multicellular organismal processGO:00512392770.098
positive regulation of cytosolic calcium ion concentrationGO:000720440.097
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.097
embryonic skeletal system morphogenesisGO:0048704930.096
cellular nitrogen compound biosynthetic processGO:00442712180.095
anterior lateral line developmentGO:004889950.095
photoreceptor cell differentiationGO:0046530550.095
response to endogenous stimulusGO:0009719830.094
tissue remodelingGO:004877140.094
cell morphogenesis involved in neuron differentiationGO:00486671630.094
regulation of biological qualityGO:00650082630.094
positive regulation of rna biosynthetic processGO:1902680570.094
cellular cation homeostasisGO:0030003170.094
skeletal system morphogenesisGO:00487051020.093
brain developmentGO:00074202930.092
cognitionGO:005089010.092
positive regulation of transportGO:005105020.089
cellular amine metabolic processGO:004410620.089
response to ketoneGO:190165410.089
locomotionGO:00400113130.088
chordate embryonic developmentGO:00430092710.087
regulation of response to oxidative stressGO:190288220.087
cellular response to chemical stimulusGO:00708871570.086
cellular response to hormone stimulusGO:0032870390.086
autophagyGO:000691440.086
negative regulation of oocyte developmentGO:006028320.086
cell part morphogenesisGO:00329902460.085
positive regulation of signalingGO:0023056560.084
vascular endothelial growth factor receptor signaling pathwayGO:0048010130.082
reproductive processGO:0022414400.081
cellular response to steroid hormone stimulusGO:0071383310.079
muscle cell differentiationGO:00426921390.077
heterocycle metabolic processGO:00464832900.077
calcium ion importGO:007050940.077
hormone mediated signaling pathwayGO:000975590.076
cyclic nucleotide biosynthetic processGO:0009190180.076
positive regulation of neural precursor cell proliferationGO:200017910.074
muscle fiber developmentGO:0048747520.074
muscle structure developmentGO:00610611960.073
positive regulation of response to stimulusGO:0048584800.073
heart developmentGO:00075073130.071
diencephalon developmentGO:0021536580.070
hormone biosynthetic processGO:004244630.069
energy reserve metabolic processGO:000611220.069
response to lipidGO:0033993600.069
aromatic compound biosynthetic processGO:00194382170.069
regulation of tube sizeGO:003515020.067
regulation of cell differentiationGO:00455951420.067
larval developmentGO:000216420.067
rna metabolic processGO:00160702190.065
regulation of cellular amine metabolic processGO:003323800.065
cellular response to endogenous stimulusGO:0071495680.064
oxidation reduction processGO:0055114410.064
regulation of sarcomere organizationGO:006029720.064
regulation of intracellular signal transductionGO:1902531570.064
regulation of oxidative stress induced cell deathGO:190320120.063
ion homeostasisGO:0050801410.063
nucleic acid metabolic processGO:00903042440.063
organic cyclic compound biosynthetic processGO:19013622230.062
positive regulation of protein metabolic processGO:0051247230.062
skeletal muscle tissue developmentGO:0007519670.061
regulation of metal ion transportGO:001095940.061
negative regulation of biological processGO:00485193040.060
Mouse
organonitrogen compound metabolic processGO:1901564740.060
somite developmentGO:0061053960.059
sensory perceptionGO:0007600390.059
cellular macromolecule biosynthetic processGO:00346452240.058
tube morphogenesisGO:00352393490.057
cellular localizationGO:0051641970.057
neuron deathGO:0070997210.056
determination of heart left right asymmetryGO:00613711170.055
response to alkaloidGO:004327920.055
transportGO:00068102200.055
regulation of cellular biosynthetic processGO:00313262450.054
Mouse
blood circulationGO:0008015870.053
divalent inorganic cation transportGO:0072511210.053
regulation of postsynaptic membrane potentialGO:006007810.053
single organism behaviorGO:0044708240.052
regulation of response to stimulusGO:00485832690.052
multi organism reproductive processGO:0044703360.051
smooth muscle contractionGO:000693920.051
phagocytosisGO:000690930.051
cerebellar granular layer formationGO:002168430.049
positive regulation of cell communicationGO:0010647560.049
sensory perception of painGO:001923310.048
response to inorganic substanceGO:0010035380.048
cellular amino acid biosynthetic processGO:000865220.047
establishment of localizationGO:00512342440.047
response to oxygen containing compoundGO:1901700550.046
response to nitrogen compoundGO:1901698190.046
cell morphogenesisGO:00009022890.046
positive regulation of secretion by cellGO:190353210.046
intramembranous ossificationGO:000195730.045
receptor internalizationGO:003162320.045
phosphorus metabolic processGO:00067931090.045
feeding behaviorGO:000763150.045
long chain fatty acid metabolic processGO:000167610.044
central nervous system developmentGO:00074173870.044
positive regulation of multicellular organismal processGO:0051240520.043
behaviorGO:0007610740.043
calcium ion transportGO:0006816180.043
phosphorylationGO:0016310690.043
positive regulation of secretionGO:005104710.042
hydrogen peroxide metabolic processGO:004274320.041
somitogenesisGO:0001756870.041
negative regulation of dna replicationGO:000815620.041
localization of cellGO:00516742440.041
carboxylic acid transportGO:004694280.041
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.041
cellular aromatic compound metabolic processGO:00067252950.041
positive regulation of cellular metabolic processGO:0031325940.041
negative regulation of cellular processGO:00485232830.040
Mouse
head developmentGO:00603223030.040
response to stressGO:00069502630.040
kidney vasculature developmentGO:006144020.040
macromolecule biosynthetic processGO:00090592270.040
regulation of signalingGO:00230512350.039
cellular response to oxygen containing compoundGO:1901701200.039
regulation of cellular response to oxidative stressGO:190040720.039
glutamate receptor signaling pathwayGO:000721510.039
cellular response to organic substanceGO:00713101050.039
axon developmentGO:00615641660.039
cellular response to lipidGO:0071396390.039
fatty acid elongationGO:003049710.038
hindbrain developmentGO:0030902910.038
negative regulation of cell communicationGO:0010648960.038
mesenchyme developmentGO:00604851270.038
cellular macromolecule metabolic processGO:00442603910.037
protein modification processGO:00362111000.037
positive regulation of embryonic developmentGO:004001930.036
regulation of apoptotic processGO:0042981980.036
hindbrain morphogenesisGO:0021575220.036
heart contractionGO:0060047710.036
embryonic skeletal joint morphogenesisGO:006027230.035
regulation of blood circulationGO:1903522320.035
regulation of cell developmentGO:00602841000.035
fatty acid biosynthetic processGO:000663340.035
regulation of cytokine productionGO:000181730.035
regulation of nucleobase containing compound metabolic processGO:00192192500.034
positive regulation of cell deathGO:0010942290.034
lipid metabolic processGO:0006629520.034
Mouse
intracellular receptor signaling pathwayGO:0030522300.034
multicellular organismal reproductive processGO:0048609350.033
divalent inorganic cation homeostasisGO:0072507220.033
cellular amino acid metabolic processGO:000652070.033
startle responseGO:000196440.033
divalent metal ion transportGO:0070838200.033
carboxylic acid metabolic processGO:0019752220.032
inorganic cation transmembrane transportGO:0098662500.032
nucleobase containing compound metabolic processGO:00061392740.032
regulation of extrinsic apoptotic signaling pathwayGO:200123630.032
cellular biosynthetic processGO:00442492860.032
Mouse
heterocycle biosynthetic processGO:00181302150.032
response to steroid hormoneGO:0048545350.031
negative regulation of growth rateGO:004596710.031
agingGO:000756820.031
steroid metabolic processGO:000820270.031
Mouse
regulation of carbohydrate biosynthetic processGO:004325510.031
Mouse
organonitrogen compound biosynthetic processGO:1901566470.031
regulation of mapk cascadeGO:0043408140.030
positive regulation of cellular amine metabolic processGO:003324000.030
female sex differentiationGO:004666040.030
response to organic cyclic compoundGO:0014070510.030
phosphate containing compound metabolic processGO:00067961080.030
purine nucleoside monophosphate catabolic processGO:000912840.030
astrocyte differentiationGO:004870810.030
cell deathGO:00082191210.029
metal ion homeostasisGO:0055065260.029
dna biosynthetic processGO:007189730.029
regulation of cellular amino acid metabolic processGO:000652100.029
cardiocyte differentiationGO:0035051440.028
digestive tract morphogenesisGO:00485462310.028
signal transduction by phosphorylationGO:0023014180.028
pancreas developmentGO:0031016840.028
positive regulation of apoptotic processGO:0043065290.028
positive regulation of macromolecule metabolic processGO:0010604930.028
response to hormoneGO:0009725480.027
purine ribonucleotide metabolic processGO:0009150270.027
regulation of macromolecule metabolic processGO:00602553170.027
sodium ion importGO:009736930.026
macromolecule localizationGO:0033036540.026
nucleobase containing compound biosynthetic processGO:00346542050.026
mitochondrion organizationGO:000700540.026
inner ear developmentGO:00488391260.026
bone remodelingGO:004684920.026
response to abiotic stimulusGO:00096281220.025
regulation of skeletal muscle tissue developmentGO:004864140.025
retina homeostasisGO:0001895120.025
cellular response to nutrient levelsGO:003166920.025
regulation of heart growthGO:006042020.025
striated muscle tissue developmentGO:00147061100.025
regulation of camp mediated signalingGO:004394910.024
regulation of sodium ion transportGO:000202820.024
regulation of behaviorGO:0050795240.024
androgen metabolic processGO:000820920.024
single organism biosynthetic processGO:0044711710.024
Mouse
diterpenoid metabolic processGO:0016101150.024
cellular protein modification processGO:00064641000.024
regulation of cellular carbohydrate metabolic processGO:001067540.023
Mouse
catechol containing compound biosynthetic processGO:000971320.023
single organism localizationGO:19025782250.023
actomyosin structure organizationGO:0031032530.023
cardiac muscle tissue developmentGO:0048738480.023
regulation of phosphorus metabolic processGO:0051174430.023
membrane hyperpolarizationGO:006008110.023
transcription dna templatedGO:00063511810.023
renal system vasculature developmentGO:006143720.023
embryonic heart tube morphogenesisGO:00031431080.023
regulation of bone remodelingGO:004685020.023
regulation of neurotransmitter secretionGO:004692810.023
eye developmentGO:00016542770.023
dopamine biosynthetic processGO:004241620.022
stem cell developmentGO:0048864820.022
organic acid metabolic processGO:0006082310.022
neuron projection morphogenesisGO:00488121610.022
regulation of programmed cell deathGO:00430671010.022
negative regulation of protein transportGO:005122430.022
cell differentiation in hindbrainGO:002153350.022
single organism organelle organizationGO:19025891990.021
positive regulation of cellular protein metabolic processGO:0032270220.021
embryonic skeletal system developmentGO:0048706970.021
regulation of phosphate metabolic processGO:0019220430.021
skeletal muscle organ developmentGO:0060538780.021
sequestering of metal ionGO:005123830.021
regulation of blood vessel sizeGO:005088020.021
muscle cell migrationGO:001481240.021
response to dexamethasoneGO:007154810.021
smooth muscle tissue developmentGO:004874510.021
multicellular organism reproductionGO:0032504350.021
positive regulation of nucleobase containing compound metabolic processGO:0045935690.021
ovarian follicle developmentGO:000154120.021
protein phosphorylationGO:0006468470.020
regulation of protein metabolic processGO:0051246560.020
regulation of gene expressionGO:00104682650.020
cerebellar granular layer morphogenesisGO:002168330.020
locomotory behaviorGO:0007626340.020
cellular response to external stimulusGO:007149620.020
cell morphogenesis involved in differentiationGO:00009041950.020
positive regulation of gene expressionGO:0010628710.020
calcium ion transmembrane transportGO:0070588130.020
eye photoreceptor cell differentiationGO:0001754450.020
adult behaviorGO:003053420.019
regulation of biosynthetic processGO:00098892500.019
Mouse
dopamine metabolic processGO:004241720.019
development of primary female sexual characteristicsGO:004654540.019
androgen biosynthetic processGO:000670210.019
nephron morphogenesisGO:007202820.019
regulation of tissue remodelingGO:003410320.019
cellular component movementGO:00069283350.019
urogenital system developmentGO:0001655970.019
actin filament based processGO:0030029640.019
fatty acid elongation unsaturated fatty acidGO:001936810.019
negative regulation of signalingGO:0023057960.018
cellular response to reactive oxygen speciesGO:003461420.018
muscle cell developmentGO:00550011150.018
cellular protein metabolic processGO:00442671290.018
regulation of molecular functionGO:0065009700.018
Mouse
macroautophagyGO:001623610.017
atp catabolic processGO:000620040.017
negative regulation of dna metabolic processGO:005105340.017
regulation of stem cell proliferationGO:007209120.017
negative regulation of kinase activityGO:003367340.017
detection of light stimulus involved in visual perceptionGO:005090870.017
cerebellar granular layer developmentGO:002168130.017
negative regulation of oxidative stress induced cell deathGO:190320220.017
locus ceruleus developmentGO:002170330.017
cell maturationGO:0048469230.017
organic anion transportGO:0015711150.017
photoreceptor cell fate specificationGO:004370410.017
thigmotaxisGO:000196650.016
ribose phosphate metabolic processGO:0019693270.016
organelle organizationGO:00069962270.016
regulation of cytoplasmic transportGO:190364940.016
response to vitamin b3GO:003355220.016
regulation of nucleic acid templated transcriptionGO:19035062130.016
regulation of multicellular organismal developmentGO:20000262230.016
organ regenerationGO:003110010.016
neutral amino acid transportGO:001580420.015
cation homeostasisGO:0055080330.015
morphogenesis of an epithelial foldGO:006057110.015
erk1 and erk2 cascadeGO:007037140.015
positive regulation of erk1 and erk2 cascadeGO:007037420.015
negative regulation of meiotic cell cycleGO:005144710.015
regulation of protein transportGO:005122330.015
cell aggregationGO:009874330.015
homeostatic processGO:00425921420.015
oxoacid metabolic processGO:0043436310.015
striated muscle contractionGO:0006941120.015
positive regulation of metabolic processGO:00098931080.014
neuroblast proliferationGO:000740520.014
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.014
g protein coupled receptor signaling pathwayGO:0007186740.014
negative regulation of hormone secretionGO:004688820.014
camp metabolic processGO:0046058110.014
regulation of i kappab kinase nf kappab signalingGO:004312240.014
hormone metabolic processGO:0042445190.014
positive regulation of rna metabolic processGO:0051254590.014
developmental growthGO:00485891660.014
biomineral tissue developmentGO:0031214130.014
positive regulation of mesenchymal cell proliferationGO:000205310.014
regulation of dendrite developmentGO:005077330.014
positive regulation of nitrogen compound metabolic processGO:0051173690.014
somatic muscle developmentGO:000752540.014
positive regulation of intracellular signal transductionGO:1902533150.014
regulation of immune system processGO:0002682340.014
lipid biosynthetic processGO:0008610220.014
positive regulation of stem cell proliferationGO:200064810.014
regulation of cellular protein metabolic processGO:0032268520.014
forebrain developmentGO:0030900960.014
regulation of dna replicationGO:000627530.013
response to nutrientGO:000758430.013
taxisGO:00423301090.013
regulation of cellular ketone metabolic processGO:001056570.013
Mouse
gland developmentGO:00487321430.013
bone mineralizationGO:003028290.013
regulation of inflammatory responseGO:005072720.013
regulation of response to nutrient levelsGO:003210710.013
negative regulation of developmental processGO:0051093650.013
response to hydrogen peroxideGO:004254230.013
multicellular organismal response to stressGO:003355520.013
intracellular transportGO:0046907320.013
ossificationGO:0001503230.013
nucleic acid templated transcriptionGO:00976591810.012
regulation of rna metabolic processGO:00512522240.012
regulation of macromolecule biosynthetic processGO:00105562250.012
er nucleus signaling pathwayGO:000698420.012
nucleoside monophosphate catabolic processGO:000912540.012
exocrine system developmentGO:0035272280.012
monoamine transportGO:001584410.012
regulation of erk1 and erk2 cascadeGO:007037240.012
cellular response to oxygen levelsGO:007145310.012
regulation of response to extracellular stimulusGO:003210410.012
voluntary skeletal muscle contractionGO:000301040.012
single organism membrane fusionGO:004480120.012
positive regulation of cellular amino acid metabolic processGO:004576400.012
regulation of cell activationGO:005086510.012
regulation of anatomical structure sizeGO:0090066330.012
anterior lateral line system developmentGO:004889890.012
cellular hormone metabolic processGO:0034754190.012
extracellular matrix organizationGO:0030198270.012
regulation of cell deathGO:00109411030.012
central nervous system neuron axonogenesisGO:0021955180.012
negative regulation of multi organism processGO:004390130.012
regulation of hormone levelsGO:0010817210.011
response to peptide hormoneGO:004343460.011
digestive tract mesoderm developmentGO:000750210.011
regulation of ion transportGO:0043269220.011
transcription from rna polymerase ii promoterGO:0006366800.011
neurotransmitter transportGO:000683620.011
cellular carbohydrate metabolic processGO:004426240.011
Mouse
regulation of protein modification processGO:0031399290.011
response to unfolded proteinGO:000698620.011
cerebellum developmentGO:0021549170.011
cellular protein complex assemblyGO:0043623190.011
liver developmentGO:0001889960.011
regulation of protein catabolic processGO:004217610.011
positive regulation of transcription dna templatedGO:0045893570.011
negative regulation of neuron deathGO:190121580.011
negative regulation of cell differentiationGO:0045596460.011
anterior posterior pattern specificationGO:00099521520.011
regulation of cellular component organizationGO:0051128860.011
negative regulation of catabolic processGO:000989530.011
apoptotic processGO:00069151160.011
regulation of nitrogen compound metabolic processGO:00511712510.011
response to foodGO:003209410.011
long chain fatty acid transportGO:001590910.011
fluid transportGO:0042044170.011
central nervous system projection neuron axonogenesisGO:0021952150.011
cellular response to starvationGO:000926710.011
macromolecular complex disassemblyGO:003298410.011
oocyte differentiationGO:0009994140.011
cellular response to stressGO:0033554620.011
cell migrationGO:00164772370.011
eye photoreceptor cell developmentGO:0042462300.011
metencephalon developmentGO:0022037270.011
organic acid biosynthetic processGO:0016053120.010
positive regulation of phosphate metabolic processGO:0045937210.010
monovalent inorganic cation transportGO:0015672420.010
mitochondrial transportGO:000683920.010
i kappab kinase nf kappab signalingGO:000724940.010
regulation of reactive oxygen species metabolic processGO:200037720.010
axonogenesisGO:00074091520.010
positive regulation of muscle tissue developmentGO:190186310.010
g2 m transition of mitotic cell cycleGO:000008640.010
cell proliferationGO:0008283800.010
negative regulation of nucleocytoplasmic transportGO:004682320.010
cell projection organizationGO:00300302840.010
establishment of protein localization to organelleGO:007259440.010
response to immobilization stressGO:003590210.010

lepr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.052
urinary system diseaseDOID:1800.052
nervous system diseaseDOID:86300.046
central nervous system diseaseDOID:33100.046
neurodegenerative diseaseDOID:128900.046
synucleinopathyDOID:005089000.046
organ system cancerDOID:005068600.026
disease of cellular proliferationDOID:1456600.026
cancerDOID:16200.026
sensory system diseaseDOID:005015500.016
auditory system diseaseDOID:274200.016
nonsyndromic deafnessDOID:005056300.016
parkinson s diseaseDOID:1433000.011