Danio rerio

4 known processes

wwp2

WW domain containing E3 ubiquitin protein ligase 2

(Aliases: wu:fo87e10,zgc:154036,id:ibd1121)

wwp2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
signal transductionGO:00071654550.372
response to stressGO:00069502630.295
agingGO:000756820.250
Worm
epithelial cell morphogenesisGO:000338220.238
embryonic organ developmentGO:00485683810.210
regulation of response to stimulusGO:00485832690.181
nuclear transportGO:005116940.177
chordate embryonic developmentGO:00430092710.174
cell surface receptor signaling pathwayGO:00071663250.174
single organism localizationGO:19025782250.170
central nervous system developmentGO:00074173870.167
larval developmentGO:000216420.161
digestive tract developmentGO:00485652650.151
regulation of metabolic processGO:00192223590.148
Worm
protein localization to nucleusGO:003450430.138
regulation of signalingGO:00230512350.136
nucleocytoplasmic transportGO:000691340.133
establishment of protein localization to organelleGO:007259440.133
digestive system developmentGO:00551232890.132
epithelial tube morphogenesisGO:00605621480.130
regulation of signal transductionGO:00099662250.126
embryonic organ morphogenesisGO:00485622740.119
ameboidal type cell migrationGO:00016671430.113
protein targeting to nucleusGO:004474430.111
response to external stimulusGO:00096052640.109
protein import into nucleusGO:000660630.108
single organism organelle organizationGO:19025891990.107
establishment of organelle localizationGO:0051656450.106
neuron differentiationGO:00301823530.104
Worm
embryo development ending in birth or egg hatchingGO:00097922710.101
Worm
cellular macromolecule metabolic processGO:00442603910.099
Worm
negative regulation of cell communicationGO:0010648960.093
cell morphogenesis involved in differentiationGO:00009041950.092
cellular component morphogenesisGO:00329893360.091
regulation of synapse assemblyGO:005196330.089
heart developmentGO:00075073130.089
gastrulationGO:00073692080.088
erk1 and erk2 cascadeGO:007037140.087
organic substance biosynthetic processGO:19015762890.086
skeletal system developmentGO:00015011810.085
tube morphogenesisGO:00352393490.084
heterocycle metabolic processGO:00464832900.082
organelle localizationGO:0051640490.081
cellular nitrogen compound metabolic processGO:00346412900.080
endosomal transportGO:001619720.080
axonogenesisGO:00074091520.079
synaptic growth at neuromuscular junctionGO:005112420.075
negative regulation of cellular processGO:00485232830.071
organelle organizationGO:00069962270.071
maintenance of locationGO:005123540.070
Worm
positive regulation of cellular catabolic processGO:003133130.070
regulation of synapse organizationGO:005080730.070
regulation of biological qualityGO:00650082630.069
Worm
golgi vesicle transportGO:004819330.066
negative regulation of metabolic processGO:0009892860.066
cellular protein metabolic processGO:00442671290.065
Worm
regulation of cell communicationGO:00106462320.065
morphogenesis of an epitheliumGO:00020093330.064
single organism nuclear importGO:190259330.064
single organism cellular localizationGO:1902580460.063
regulation of cellular metabolic processGO:00313233200.063
axon developmentGO:00615641660.062
Worm
single organism metabolic processGO:00447102170.061
regulation of synaptic plasticityGO:004816710.061
regulation of erk1 and erk2 cascadeGO:007037240.061
positive regulation of cellular component biogenesisGO:004408930.061
nuclear importGO:005117030.060
positive regulation of biological processGO:00485182530.060
brain developmentGO:00074202930.059
negative regulation of mapk cascadeGO:004340940.059
biosynthetic processGO:00090582940.059
single organism transportGO:00447652060.057
actin polymerization or depolymerizationGO:000815420.057
cellular macromolecule biosynthetic processGO:00346452240.057
enzyme linked receptor protein signaling pathwayGO:00071671060.057
embryonic limb morphogenesisGO:003032620.056
protein importGO:001703830.055
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.055
regulation of biosynthetic processGO:00098892500.055
regulation of bindingGO:005109830.055
regulation of intracellular signal transductionGO:1902531570.054
cell projection organizationGO:00300302840.054
Worm
digestive tract morphogenesisGO:00485462310.053
proteolysis involved in cellular protein catabolic processGO:005160330.052
cell morphogenesis involved in neuron differentiationGO:00486671630.052
embryonic skeletal system developmentGO:0048706970.052
cell projection morphogenesisGO:00488582440.051
meiotic nuclear divisionGO:000712640.051
cellular localizationGO:0051641970.051
organic cyclic compound metabolic processGO:19013603010.051
synaptic vesicle localizationGO:009747910.050
regulation of nitrogen compound metabolic processGO:00511712510.050
compound eye developmentGO:004874920.049
embryonic skeletal system morphogenesisGO:0048704930.049
chromosome organizationGO:0051276310.048
regulation of programmed cell deathGO:00430671010.048
negative regulation of signal transductionGO:0009968940.048
regulation of cytoplasmic transportGO:190364940.048
synaptic vesicle transportGO:004848910.048
multi organism processGO:00517041340.048
cartilage developmentGO:0051216960.047
neuron developmentGO:00486662620.047
Worm
protein polymerizationGO:005125840.046
phagocytosisGO:000690930.046
regulation of multicellular organism growthGO:004001440.046
modification dependent macromolecule catabolic processGO:004363230.046
positive regulation of cellular processGO:00485222010.046
developmental growthGO:00485891660.046
sensory organ developmentGO:00074233930.046
embryonic cranial skeleton morphogenesisGO:0048701900.045
establishment of localization in cellGO:0051649770.045
response to organic substanceGO:00100331530.045
skeletal system morphogenesisGO:00487051020.045
cognitionGO:005089010.044
regulation of cell shapeGO:000836010.044
positive regulation of transportGO:005105020.044
establishment of protein localization to plasma membraneGO:009000210.044
cellular response to starvationGO:000926710.044
phosphorus metabolic processGO:00067931090.044
small molecule metabolic processGO:0044281770.044
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.044
connective tissue developmentGO:0061448990.044
regulation of protein transportGO:005122330.043
cellular protein catabolic processGO:004425740.043
olfactory lobe developmentGO:002198840.043
positive regulation of stress activated mapk cascadeGO:003287430.042
nitrogen compound metabolic processGO:00068073190.042
cellular aromatic compound metabolic processGO:00067252950.042
negative regulation of response to stimulusGO:00485851040.042
taxisGO:00423301090.042
multicellular organismal metabolic processGO:004423620.041
apoptotic processGO:00069151160.041
multicellular organism growthGO:003526440.041
actin filament based movementGO:003004810.041
mesenchymal cell developmentGO:0014031780.041
regulation of establishment of protein localizationGO:007020140.041
vesicle localizationGO:0051648270.040
collagen metabolic processGO:003296320.040
cellular response to extracellular stimulusGO:003166820.039
determination of bilateral symmetryGO:00098552040.039
regulation of autophagyGO:001050630.039
establishment of localizationGO:00512342440.039
multicellular organismal macromolecule metabolic processGO:004425920.038
localization of cellGO:00516742440.037
adult behaviorGO:003053420.037
autophagyGO:000691440.037
intracellular signal transductionGO:0035556850.037
cell migration involved in gastrulationGO:0042074790.037
embryonic viscerocranium morphogenesisGO:0048703520.037
positive regulation of stem cell proliferationGO:200064810.037
response to chemicalGO:00422213200.036
protein metabolic processGO:00195381830.036
Worm
regulation of protein targetingGO:190353320.036
generation of neuronsGO:00486993850.035
Worm
neurotransmitter secretionGO:000726920.035
appendage morphogenesisGO:0035107560.035
cellular carbohydrate metabolic processGO:004426240.035
hormone transportGO:000991420.035
regulation of protein bindingGO:004339330.035
regulation of intracellular protein transportGO:003315730.034
immune system processGO:00023762410.034
meiotic cell cycle processGO:190304630.034
regulation of response to extracellular stimulusGO:003210410.034
macromolecule localizationGO:0033036540.034
Worm
proteasomal protein catabolic processGO:001049820.034
organelle assemblyGO:00709251100.033
cell morphogenesisGO:00009022890.033
circadian regulation of gene expressionGO:003292280.033
response to uvGO:000941130.033
cellular biosynthetic processGO:00442492860.033
gastrulation with mouth forming secondGO:0001702440.033
cell part morphogenesisGO:00329902460.033
axon guidanceGO:0007411860.033
pancreas developmentGO:0031016840.032
meiotic chromosome segregationGO:004513230.032
cell substrate adhesionGO:003158940.032
protein localization to plasma membraneGO:007265910.032
dicarboxylic acid metabolic processGO:004364810.032
neural crest cell developmentGO:0014032620.032
vacuolar transportGO:000703420.032
regulation of protein modification by small protein conjugation or removalGO:190332030.032
gtp metabolic processGO:004603940.032
angiogenesisGO:00015251580.032
regulation of macromolecule metabolic processGO:00602553170.032
Worm
negative regulation of protein phosphorylationGO:000193340.031
regulation of filopodium assemblyGO:005148920.031
neuron projection morphogenesisGO:00488121610.031
transportGO:00068102200.031
neurotransmitter transportGO:000683620.031
mesenchyme developmentGO:00604851270.031
homeostatic processGO:00425921420.030
establishment of synaptic vesicle localizationGO:009748010.030
positive regulation of catabolic processGO:000989640.030
ubiquitin dependent protein catabolic processGO:000651130.030
regulation of rna metabolic processGO:00512522240.030
regulation of response to nutrient levelsGO:003210710.029
convergent extensionGO:00600261180.029
protein acylationGO:004354330.029
transcription dna templatedGO:00063511810.029
nucleic acid templated transcriptionGO:00976591810.029
regulation of apoptotic processGO:0042981980.029
cell deathGO:00082191210.029
regulation of neural precursor cell proliferationGO:200017730.029
positive regulation of cell cycleGO:004578730.029
regulation of tube sizeGO:003515020.029
stem cell proliferationGO:007208940.029
regulation of nucleocytoplasmic transportGO:004682220.028
small gtpase mediated signal transductionGO:000726480.028
cellular component movementGO:00069283350.028
modification dependent protein catabolic processGO:001994130.028
leukocyte proliferationGO:007066110.028
regulation of chondrocyte differentiationGO:003233010.028
er to golgi vesicle mediated transportGO:000688810.027
regulation of cellular response to growth factor stimulusGO:0090287350.027
regulation of synaptic growth at neuromuscular junctionGO:000858210.027
vasculature developmentGO:00019442780.027
wnt signaling pathwayGO:0016055800.027
positive regulation of protein complex assemblyGO:003133420.027
organonitrogen compound metabolic processGO:1901564740.027
cellular modified amino acid metabolic processGO:000657530.026
response to topologically incorrect proteinGO:003596620.026
organic cyclic compound biosynthetic processGO:19013622230.026
eye developmentGO:00016542770.026
deathGO:00162651210.026
alpha amino acid metabolic processGO:190160530.026
regulation of localizationGO:00328791040.026
regulation of gene expressionGO:00104682650.026
ras protein signal transductionGO:000726570.026
regulation of protein localization to nucleusGO:190018020.026
positive regulation of epithelial cell differentiationGO:003085820.026
hematopoietic or lymphoid organ developmentGO:00485341910.026
regulation of developmental processGO:00507932470.025
hormone secretionGO:004687920.025
otic vesicle developmentGO:0071599420.025
nuclear exportGO:005116810.025
regulation of anatomical structure morphogenesisGO:00226031300.025
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.025
phosphate containing compound metabolic processGO:00067961080.025
regionalizationGO:00030022740.025
single organism reproductive processGO:0044702400.025
blood vessel developmentGO:00015682460.025
positive regulation of neuron deathGO:190121610.025
negative regulation of cytoplasmic transportGO:190365020.025
rna localizationGO:000640340.025
negative regulation of protein transportGO:005122430.024
gtp catabolic processGO:000618420.024
cellular response to nutrient levelsGO:003166920.024
negative regulation of intracellular transportGO:003238730.024
negative regulation of signalingGO:0023057960.024
multicellular organismal reproductive processGO:0048609350.024
protein modification processGO:00362111000.024
Worm
cellular amino acid metabolic processGO:000652070.024
epithelial cell differentiationGO:00308551160.024
negative regulation of biological processGO:00485193040.024
regulation of wnt signaling pathwayGO:0030111530.024
neuron projection developmentGO:00311751800.024
Worm
female gonad developmentGO:000858540.024
nephron tubule morphogenesisGO:007207810.024
mesenchymal cell proliferationGO:001046310.024
positive regulation of response to stimulusGO:0048584800.023
macromolecule biosynthetic processGO:00090592270.023
reproductive processGO:0022414400.023
macromolecule modificationGO:00434121110.023
Worm
cellular response to external stimulusGO:007149620.023
locomotionGO:00400113130.023
Worm
phosphorylationGO:0016310690.023
oxoacid metabolic processGO:0043436310.023
cell agingGO:000756920.023
blood vessel morphogenesisGO:00485142160.023
extrinsic apoptotic signaling pathwayGO:009719130.022
protein targeting to vacuoleGO:000662310.022
regulation of cellular biosynthetic processGO:00313262450.022
growthGO:00400071740.022
exocytosisGO:000688710.022
nucleic acid transportGO:005065720.022
tube formationGO:0035148250.022
regulation of photoreceptor cell differentiationGO:004653220.022
negative regulation of protein kinase activityGO:000646940.022
cell cycleGO:0007049930.022
heterocycle biosynthetic processGO:00181302150.022
eye morphogenesisGO:00485921440.022
regulation of protein catabolic processGO:004217610.022
Worm
multi organism reproductive processGO:0044703360.022
regulation of locomotionGO:0040012550.021
regulation of mapk cascadeGO:0043408140.021
endomembrane system organizationGO:0010256130.021
nucleic acid metabolic processGO:00903042440.021
regulation of cell activationGO:005086510.021
regulation of multicellular organismal developmentGO:20000262230.021
histone lysine demethylationGO:007007620.021
histone demethylationGO:001657720.021
regulation of myotube differentiationGO:001083020.021
negative regulation of kinase activityGO:003367340.021
response to woundingGO:00096111160.021
mononuclear cell proliferationGO:003294310.021
retina development in camera type eyeGO:00600411460.021
protein dephosphorylationGO:000647030.020
cellular response to retinoic acidGO:007130010.020
guanosine containing compound metabolic processGO:190106840.020
specification of axis polarityGO:006500140.020
membrane organizationGO:0061024210.020
establishment of vesicle localizationGO:0051650240.020
organic acid metabolic processGO:0006082310.020
programmed cell deathGO:00125011190.020
negative regulation of biosynthetic processGO:0009890550.020
aromatic compound biosynthetic processGO:00194382170.020
mesenchymal cell differentiationGO:0048762870.020
regulation of reproductive processGO:200024140.020
embryonic foregut morphogenesisGO:004861710.020
intracellular transportGO:0046907320.020
regulation of nucleobase containing compound metabolic processGO:00192192500.020
single organismal cell cell adhesionGO:0016337290.020
regulation of multicellular organismal processGO:00512392770.020
regulation of nucleic acid templated transcriptionGO:19035062130.020
rna transportGO:005065820.020
limb bud formationGO:006017420.019
mitochondrion organizationGO:000700540.019
macromolecular complex subunit organizationGO:0043933740.019
sexual reproductionGO:0019953360.019
regulation of embryonic developmentGO:0045995470.019
regulation of cellular amine metabolic processGO:003323800.019
positive regulation of secretionGO:005104710.019
synaptic vesicle recyclingGO:003646510.019
macroautophagyGO:001623610.019
neuron deathGO:0070997210.018
regulation of protein import into nucleusGO:004230620.018
negative regulation of intracellular protein transportGO:009031730.018
regulation of cell morphogenesisGO:0022604420.018
development of primary female sexual characteristicsGO:004654540.018
neuron projection guidanceGO:0097485860.018
regulation of skeletal muscle tissue developmentGO:004864140.018
regulation of exocytosisGO:001715710.018
regulation of phosphorus metabolic processGO:0051174430.018
branching morphogenesis of a nerveGO:004875540.018
smooth muscle tissue developmentGO:004874510.018
amine metabolic processGO:000930820.018
regulation of bone mineralizationGO:003050020.018
g protein coupled receptor signaling pathwayGO:0007186740.018
signal transduction by phosphorylationGO:0023014180.018
regulation of protein complex assemblyGO:004325430.018
dicarboxylic acid transportGO:000683510.018
endocrine hormone secretionGO:006098620.018
somatic muscle developmentGO:000752540.018
system processGO:00030081850.018
positive regulation of cell communicationGO:0010647560.018
negative regulation of gliogenesisGO:001401410.017
regulation of cellular component organizationGO:0051128860.017
organonitrogen compound biosynthetic processGO:1901566470.017
chemotaxisGO:00069351040.017
regulation of growthGO:0040008420.017
transcription from rna polymerase ii promoterGO:0006366800.017
regulation of cell deathGO:00109411030.017
synaptic vesicle endocytosisGO:004848810.017
erythrocyte homeostasisGO:0034101550.017
regulation of transcription dna templatedGO:00063552130.017
negative regulation of cytokine productionGO:000181810.017
regulation of cytokine productionGO:000181730.017
developmental growth involved in morphogenesisGO:0060560860.017
endocardial cushion morphogenesisGO:000320330.017
regulation of cell projection assemblyGO:006049140.017
bmp signaling pathwayGO:0030509520.017
notochord developmentGO:0030903540.017
tissue homeostasisGO:0001894250.017
cellular nitrogen compound biosynthetic processGO:00442712180.017
regulation of cellular amino acid metabolic processGO:000652100.017
myeloid cell homeostasisGO:0002262560.017
cytoplasmic transportGO:0016482110.016
negative regulation of leukocyte differentiationGO:190210610.016
homeostasis of number of cellsGO:0048872620.016
embryonic neurocranium morphogenesisGO:0048702150.016
negative regulation of small gtpase mediated signal transductionGO:005105810.016
head developmentGO:00603223030.016
regulation of gtp catabolic processGO:003312420.016
appendage developmentGO:0048736800.016
regulation of blood vessel sizeGO:005088020.016
nucleobase containing compound metabolic processGO:00061392740.016
transcription elongation from rna polymerase ii promoterGO:000636830.016
positive regulation of exocytosisGO:004592110.016
endosome organizationGO:000703220.016
regulation of cell migrationGO:0030334400.016
negative regulation of histone modificationGO:003105710.016
regulation of protein ubiquitinationGO:003139630.016
single organism biosynthetic processGO:0044711710.016
cellular response to chemical stimulusGO:00708871570.016
guanosine containing compound catabolic processGO:190106920.016
regulation of cellular component movementGO:0051270550.015
peptide transportGO:001583310.015
photoreceptor cell differentiationGO:0046530550.015
tissue remodelingGO:004877140.015
cellular response to organic substanceGO:00713101050.015
nephron epithelium morphogenesisGO:007208810.015
positive regulation of secretion by cellGO:190353210.015
negative regulation of synapse assemblyGO:005196420.015
odontogenesis of dentin containing toothGO:004247510.015
organelle transport along microtubuleGO:007238410.015
regulation of response to stressGO:0080134360.015
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.015
blood circulationGO:0008015870.015
female meiotic divisionGO:000714320.015
determination of heart left right asymmetryGO:00613711170.015
pyruvate metabolic processGO:000609010.015
positive regulation of erk1 and erk2 cascadeGO:007037420.015
regulation of protein polymerizationGO:003227120.015
neural retina developmentGO:0003407490.015
regulation of dna templated transcription in response to stressGO:004362000.015
regulation of neuronal synaptic plasticityGO:004816810.015
negative regulation of chromosome organizationGO:200125110.015
embryonic skeletal joint developmentGO:007249830.015
immune system developmentGO:00025201910.015
cellular component biogenesisGO:00440851780.015
negative regulation of macromolecule biosynthetic processGO:0010558480.014
regulation of receptor activityGO:001046920.014
negative regulation of cell deathGO:0060548600.014
regulation of cellular carbohydrate metabolic processGO:001067540.014
regulation of developmental growthGO:0048638380.014
regulation of skeletal muscle fiber developmentGO:004874220.014
positive regulation of cell activationGO:005086710.014
establishment of endothelial barrierGO:006102830.014
gene expressionGO:00104672520.014
cellular amine metabolic processGO:004410620.014
positive regulation of reproductive processGO:200024320.014
cellular component assemblyGO:00226071700.014
muscle cell migrationGO:001481240.014
p38mapk cascadeGO:003806610.014
protein localizationGO:0008104400.014
lymphocyte proliferationGO:004665110.014
spermatid differentiationGO:004851520.014
outflow tract morphogenesisGO:000315110.014
negative regulation of nucleocytoplasmic transportGO:004682320.014
adherens junction organizationGO:003433240.014
actin filament polymerizationGO:003004120.014
regulation of rna biosynthetic processGO:20011412130.014
microtubule organizing center organizationGO:003102310.014
dna templated transcription elongationGO:000635430.014
organic substance transportGO:0071702580.014
regulation of mesenchymal cell proliferationGO:001046410.014
leukocyte homeostasisGO:000177620.014
sensory organ morphogenesisGO:00905962000.013
mesoderm developmentGO:0007498880.013
positive regulation of cell migrationGO:0030335110.013
cellular amide metabolic processGO:004360340.013
response to light stimulusGO:0009416460.013
rna biosynthetic processGO:00327741810.013
male meiosisGO:000714020.013
pectoral fin developmentGO:0033339500.013
protein demethylationGO:000648220.013
homeostasis of number of cells within a tissueGO:004887340.013
morphogenesis of a branching structureGO:0001763210.013
positive regulation of wound healingGO:009030310.013
single organism cell adhesionGO:0098602290.013
fat soluble vitamin metabolic processGO:000677540.013
female sex differentiationGO:004666040.013
regulation of lipase activityGO:006019120.013
peptidyl serine phosphorylationGO:001810510.013
peptidyl threonine modificationGO:001821010.013
cell proliferation involved in heart morphogenesisGO:006132320.013
developmental cell growthGO:0048588520.013
regulation of carbohydrate metabolic processGO:000610940.013
regulation of molecular functionGO:0065009700.013
developmental process involved in reproductionGO:0003006270.013
regulation of cell fate specificationGO:0042659200.013
stem cell fate commitmentGO:004886510.013
positive regulation of neuron apoptotic processGO:004352510.013
glucose homeostasisGO:004259310.013
negative regulation of autophagyGO:001050710.013
regulation of cell proliferation involved in heart morphogenesisGO:200013620.013
regulation of biomineral tissue developmentGO:007016720.013
cortical cytoskeleton organizationGO:003086510.013
determination of left right symmetryGO:00073681790.013
calcium dependent cell cell adhesion via plasma membrane cell adhesion moleculesGO:001633920.013
amide biosynthetic processGO:004360410.013
cellular protein localizationGO:0034613200.013
response to abiotic stimulusGO:00096281220.013
regulation of dendrite morphogenesisGO:004881430.013
negative regulation of intracellular signal transductionGO:1902532220.012
positive regulation of dna metabolic processGO:005105410.012
heart morphogenesisGO:00030071560.012
regulation of cellular ketone metabolic processGO:001056570.012
positive regulation of striated muscle tissue developmentGO:004584410.012
erythrocyte differentiationGO:0030218540.012
ovulation cycle processGO:002260220.012
embryonic heart tube morphogenesisGO:00031431080.012
collagen biosynthetic processGO:003296420.012
mitotic cell cycleGO:0000278640.012
regulation of macromolecule biosynthetic processGO:00105562250.012
negative regulation of macromolecule metabolic processGO:0010605760.012
negative regulation of apoptotic processGO:0043066550.012
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.012
response to monosaccharideGO:003428430.012
positive regulation of cytoskeleton organizationGO:005149530.012
cellular response to stressGO:0033554620.012
photoreceptor cell maintenanceGO:0045494110.012
photoreceptor cell fate commitmentGO:004655210.012
cell motilityGO:00488702440.012

wwp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.035
organ system cancerDOID:005068600.035
cancerDOID:16200.035
disease of anatomical entityDOID:700.024
nervous system diseaseDOID:86300.014