Danio rerio

0 known processes

top1l

topoisomerase (DNA) I, like

(Aliases: wu:fc66a02,zgc:136349)

top1l biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
agingGO:000756820.146
larval developmentGO:000216420.143
nucleocytoplasmic transportGO:000691340.138
ribonucleoside monophosphate catabolic processGO:000915840.121
response to abiotic stimulusGO:00096281220.116
regulation of circadian rhythmGO:004275240.108
single organism metabolic processGO:00447102170.093
negative regulation of biological processGO:00485193040.088
nucleoside monophosphate catabolic processGO:000912540.088
atp catabolic processGO:000620040.085
multicellular organism growthGO:003526440.081
organelle organizationGO:00069962270.080
Human
nuclear transportGO:005116940.079
single fertilizationGO:000733830.076
regulation of gene expressionGO:00104682650.075
Human
purine nucleoside monophosphate catabolic processGO:000912840.074
regulation of macromolecule metabolic processGO:00602553170.070
Human
cellular macromolecule metabolic processGO:00442603910.070
Human
autophagyGO:000691440.068
purine ribonucleoside monophosphate catabolic processGO:000916940.067
positive regulation of cell cycleGO:004578730.065
establishment of localizationGO:00512342440.065
signal transductionGO:00071654550.062
regulation of extrinsic apoptotic signaling pathwayGO:200123630.058
tube morphogenesisGO:00352393490.057
cellular component movementGO:00069283350.056
extrinsic apoptotic signaling pathwayGO:009719130.056
cellular component biogenesisGO:00440851780.055
spermatid developmentGO:000728620.054
regulation of developmental processGO:00507932470.053
response to radiationGO:0009314510.053
maintenance of locationGO:005123540.052
protein metabolic processGO:00195381830.050
positive regulation of translationGO:004572710.050
gene expressionGO:00104672520.050
Human
oocyte anterior posterior axis specificationGO:000731440.049
morphogenesis of an epitheliumGO:00020093330.048
generation of neuronsGO:00486993850.048
cellular nitrogen compound metabolic processGO:00346412900.048
Human
translational initiationGO:000641330.048
negative regulation of protein kinase activityGO:000646940.046
cellular carbohydrate metabolic processGO:004426240.045
nuclear exportGO:005116810.045
regulation of protein modification by small protein conjugation or removalGO:190332030.043
stem cell maintenanceGO:001982740.043
regulation of protein ubiquitinationGO:003139630.043
regulation of cell shapeGO:000836010.043
rna localizationGO:000640340.042
digestive tract morphogenesisGO:00485462310.042
regulation of translational initiationGO:000644610.042
regulation of mrna processingGO:005068430.041
circadian rhythmGO:0007623190.040
Human
cellular protein metabolic processGO:00442671290.040
response to chemicalGO:00422213200.040
Human
cytoplasm organizationGO:000702840.040
er to golgi vesicle mediated transportGO:000688810.040
regulation of protein transportGO:005122330.040
growthGO:00400071740.039
organic cyclic compound metabolic processGO:19013603010.039
Human
regulation of biological qualityGO:00650082630.038
response to drugGO:004249330.037
Human
neuron differentiationGO:00301823530.037
digestive system developmentGO:00551232890.036
digestive tract developmentGO:00485652650.036
positive regulation of biological processGO:00485182530.036
macromolecule biosynthetic processGO:00090592270.036
positive regulation of cellular catabolic processGO:003133130.036
spermatid differentiationGO:004851520.035
positive regulation of catabolic processGO:000989640.035
regulation of cytoplasmic transportGO:190364940.035
regulation of signal transductionGO:00099662250.035
phagocytosisGO:000690930.035
apoptotic processGO:00069151160.035
oocyte maturationGO:000155640.035
regulation of skeletal muscle tissue developmentGO:004864140.034
protein importGO:001703830.034
regulation of metabolic processGO:00192223590.034
Human
regulation of cell communicationGO:00106462320.034
single organism nuclear importGO:190259330.033
entrainment of circadian clockGO:000964920.033
macromolecular complex subunit organizationGO:0043933740.033
Human
regulation of stem cell differentiationGO:200073640.033
nuclear importGO:005117030.032
locomotionGO:00400113130.032
single organism organelle organizationGO:19025891990.032
pole plasm assemblyGO:000731540.032
response to external stimulusGO:00096052640.031
alternative mrna splicing via spliceosomeGO:000038010.031
cellular macromolecule biosynthetic processGO:00346452240.031
regulation of nucleoside metabolic processGO:000911820.030
regulation of alternative mrna splicing via spliceosomeGO:000038110.029
small molecule metabolic processGO:0044281770.029
regulation of nucleotide catabolic processGO:003081120.029
positive regulation of apoptotic signaling pathwayGO:200123510.029
regulation of cellular biosynthetic processGO:00313262450.028
embryo development ending in birth or egg hatchingGO:00097922710.028
negative regulation of kinase activityGO:003367340.028
cell morphogenesisGO:00009022890.028
regulation of establishment of protein localizationGO:007020140.028
establishment of protein localization to organelleGO:007259440.028
chemosensory behaviorGO:000763510.027
phosphate containing compound metabolic processGO:00067961080.027
germ line stem cell maintenanceGO:003071820.027
mitochondrion organizationGO:000700540.027
regulation of primary metabolic processGO:00800903110.027
regulation of cell differentiationGO:00455951420.027
negative regulation of cellular processGO:00485232830.027
regulation of purine nucleotide catabolic processGO:003312120.027
negative regulation of signal transductionGO:0009968940.026
response to uvGO:000941130.026
synaptic growth at neuromuscular junctionGO:005112420.026
meiotic cell cycle processGO:190304630.026
fertilizationGO:000956630.026
response to nutrientGO:000758430.026
cellular component morphogenesisGO:00329893360.026
maternal determination of anterior posterior axis embryoGO:000835840.026
striated muscle cell differentiationGO:00511461290.025
regulation of signalingGO:00230512350.025
nitrogen compound metabolic processGO:00068073190.025
Human
organonitrogen compound metabolic processGO:1901564740.024
heterocycle metabolic processGO:00464832900.024
Human
regulation of dendrite morphogenesisGO:004881430.024
double strand break repairGO:000630230.024
muscle cell differentiationGO:00426921390.024
single organism localizationGO:19025782250.024
ameboidal type cell migrationGO:00016671430.024
organic acid metabolic processGO:0006082310.024
response to light stimulusGO:0009416460.024
positive regulation of nucleoside metabolic processGO:004597910.023
muscle structure developmentGO:00610611960.023
negative regulation of protein serine threonine kinase activityGO:007190120.023
gastrulationGO:00073692080.023
negative regulation of cytoplasmic transportGO:190365020.023
golgi vesicle transportGO:004819330.023
positive regulation of transportGO:005105020.022
negative regulation of macromolecule metabolic processGO:0010605760.022
response to monosaccharideGO:003428430.022
negative regulation of protein phosphorylationGO:000193340.022
cell substrate adhesionGO:003158940.022
regulation of multicellular organism growthGO:004001440.022
stem cell divisionGO:001714510.022
organelle assemblyGO:00709251100.022
adult behaviorGO:003053420.022
regulation of protein complex assemblyGO:004325430.022
positive regulation of nucleotide catabolic processGO:003081310.022
macromolecule modificationGO:00434121110.022
rna export from nucleusGO:000640510.022
positive regulation of map kinase activityGO:004340630.022
positive regulation of purine nucleotide catabolic processGO:003312310.021
cellular response to chemical stimulusGO:00708871570.021
meiotic chromosome segregationGO:004513230.021
neuron developmentGO:00486662620.021
proteolysis involved in cellular protein catabolic processGO:005160330.021
neurotransmitter transportGO:000683620.021
regulation of dendrite developmentGO:005077330.021
regulation of cellular protein metabolic processGO:0032268520.021
phosphorus metabolic processGO:00067931090.021
protein localization to nucleusGO:003450430.021
macromolecular complex disassemblyGO:003298410.021
regulation of synaptic plasticityGO:004816710.021
response to carbohydrateGO:000974330.021
brain developmentGO:00074202930.021
immune system processGO:00023762410.020
energy reserve metabolic processGO:000611220.020
oxoacid metabolic processGO:0043436310.020
transportGO:00068102200.020
peptidyl serine modificationGO:001820920.020
cell part morphogenesisGO:00329902460.020
locomotor rhythmGO:004547530.020
response to stressGO:00069502630.020
rna transportGO:005065820.020
g2 dna damage checkpointGO:003157230.020
regulation of carbohydrate metabolic processGO:000610940.020
localization of cellGO:00516742440.020
biosynthetic processGO:00090582940.020
pronuclear migrationGO:003504610.019
neuron projection developmentGO:00311751800.019
regulation of cellular metabolic processGO:00313233200.019
single organism transportGO:00447652060.019
cell deathGO:00082191210.019
carboxylic acid metabolic processGO:0019752220.019
blood vessel morphogenesisGO:00485142160.019
lipid storageGO:001991510.019
epithelial tube morphogenesisGO:00605621480.019
meiotic nuclear divisionGO:000712640.019
protein targeting to nucleusGO:004474430.019
cellular response to extracellular stimulusGO:003166820.019
regulation of chromosome segregationGO:005198310.019
peptidyl serine phosphorylationGO:001810510.019
negative regulation of map kinase activityGO:004340720.019
organic substance biosynthetic processGO:19015762890.019
regulation of response to nutrient levelsGO:003210710.019
positive regulation of cytoskeleton organizationGO:005149530.018
mitotic dna integrity checkpointGO:004477440.018
somatic muscle developmentGO:000752540.018
cellular localizationGO:0051641970.018
modification dependent protein catabolic processGO:001994130.018
intracellular mrna localizationGO:000829810.018
axon developmentGO:00615641660.018
regulation of metal ion transportGO:001095940.018
developmental growthGO:00485891660.018
regulation of peptidyl tyrosine phosphorylationGO:005073010.018
recombinational repairGO:000072510.018
cellular amino acid metabolic processGO:000652070.018
reproductive processGO:0022414400.018
cellular response to unfolded proteinGO:003462020.018
adherens junction organizationGO:003433240.018
cellular aromatic compound metabolic processGO:00067252950.018
Human
signal transduction in absence of ligandGO:003803410.018
nucleobase containing compound transportGO:001593120.018
neuron neuron synaptic transmissionGO:000727010.017
guanosine containing compound metabolic processGO:190106840.017
cellular response to external stimulusGO:007149620.017
nuclear migrationGO:000709730.017
carbohydrate biosynthetic processGO:001605110.017
regulation of protein targetingGO:190353320.017
response to glucoseGO:000974930.017
gamete generationGO:0007276330.017
nucleic acid transportGO:005065720.017
regulation of synapse organizationGO:005080730.017
regulation of nucleocytoplasmic transportGO:004682220.017
gtp catabolic processGO:000618420.017
cellular biosynthetic processGO:00442492860.017
cellular amine metabolic processGO:004410620.017
protein dephosphorylationGO:000647030.017
3 utr mediated mrna stabilizationGO:007093530.017
regulation of cell activationGO:005086510.017
cell morphogenesis involved in neuron differentiationGO:00486671630.017
cell substrate junction assemblyGO:000704420.017
regulation of intracellular protein transportGO:003315730.016
regulation of cytokine productionGO:000181730.016
regulation of apoptotic processGO:0042981980.016
regulation of dna replicationGO:000627530.016
photoperiodismGO:0009648110.016
protein complex disassemblyGO:004324110.016
regulation of reproductive processGO:200024140.016
organelle fusionGO:004828430.016
nucleobase containing compound metabolic processGO:00061392740.016
Human
regulation of programmed cell deathGO:00430671010.016
regulation of mrna splicing via spliceosomeGO:004802430.016
positive regulation of cellular component biogenesisGO:004408930.016
establishment of localization in cellGO:0051649770.016
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.016
protein import into nucleusGO:000660630.016
regulation of macromolecule biosynthetic processGO:00105562250.016
regulation of response to stimulusGO:00485832690.016
calcium mediated signalingGO:001972220.015
alpha amino acid metabolic processGO:190160530.015
cell morphogenesis involved in differentiationGO:00009041950.015
cell surface receptor signaling pathwayGO:00071663250.015
regulation of multicellular organismal processGO:00512392770.015
cellular component assembly involved in morphogenesisGO:00109271070.015
internal protein amino acid acetylationGO:000647520.015
response to topologically incorrect proteinGO:003596620.015
modification dependent macromolecule catabolic processGO:004363230.015
cellular component disassemblyGO:002241110.015
regulation of neurotransmitter transportGO:005158810.015
guanosine containing compound catabolic processGO:190106920.015
cell cycle g1 s phase transitionGO:004484310.015
regulation of protein localization to nucleusGO:190018020.015
posttranscriptional regulation of gene expressionGO:0010608140.015
cell cycleGO:0007049930.015
gtp metabolic processGO:004603940.015
regulation of multicellular organismal developmentGO:20000262230.015
regulation of epidermis developmentGO:004568220.015
negative regulation of response to stimulusGO:00485851040.015
female sex differentiationGO:004666040.015
angiogenesisGO:00015251580.015
cell matrix adhesionGO:000716040.014
sister chromatid cohesionGO:000706220.014
skeletal muscle organ developmentGO:0060538780.014
camera type eye developmentGO:00430102220.014
embryonic organ developmentGO:00485683810.014
anterior posterior pattern specificationGO:00099521520.014
regulation of tube sizeGO:003515020.014
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.014
response to hexoseGO:000974630.014
cell projection organizationGO:00300302840.014
development of primary female sexual characteristicsGO:004654540.014
leukocyte proliferationGO:007066110.014
cellular response to nutrient levelsGO:003166920.014
regulation of protein metabolic processGO:0051246560.014
cell migrationGO:00164772370.014
organism emergence from protective structureGO:007168440.014
synaptic vesicle transportGO:004848910.014
mrna stabilizationGO:004825540.014
rhythmic processGO:0048511210.014
Human
female gonad developmentGO:000858540.014
regulation of cell deathGO:00109411030.014
oogenesisGO:0048477140.014
negative regulation of intracellular transportGO:003238730.014
head developmentGO:00603223030.014
regulation of cellular amino acid metabolic processGO:000652100.014
negative regulation of synapse assemblyGO:005196420.014
positive regulation of dna metabolic processGO:005105410.013
system processGO:00030081850.013
positive regulation of cellular processGO:00485222010.013
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.013
skeletal muscle tissue developmentGO:0007519670.013
regulation of i kappab kinase nf kappab signalingGO:004312240.013
cytokinesisGO:000091030.013
regulation of myotube differentiationGO:001083020.013
multi organism reproductive processGO:0044703360.013
g1 s transition of mitotic cell cycleGO:000008210.013
cellular response to stressGO:0033554620.013
protein acetylationGO:000647320.013
mitochondrial transportGO:000683920.013
actin cytoskeleton organizationGO:0030036630.013
synaptic vesicle localizationGO:009747910.013
exocytosisGO:000688710.013
sensory perception of painGO:001923310.013
muscle tissue developmentGO:00605371100.013
internal peptidyl lysine acetylationGO:001839320.013
negative regulation of nucleocytoplasmic transportGO:004682320.013
regulation of cellular component organizationGO:0051128860.013
positive regulation of macromolecule metabolic processGO:0010604930.013
sexual reproductionGO:0019953360.013
regulation of neuronal synaptic plasticityGO:004816810.013
regulation of cellular ketone metabolic processGO:001056570.013
inner ear developmentGO:00488391260.013
negative regulation of protein transportGO:005122430.013
regionalizationGO:00030022740.013
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
multicellular organismal reproductive processGO:0048609350.012
endoplasmic reticulum unfolded protein responseGO:003096820.012
antimicrobial humoral responseGO:001973020.012
cellular component maintenanceGO:004395430.012
deathGO:00162651210.012
cytoskeleton organizationGO:0007010960.012
multi organism processGO:00517041340.012
hemopoiesisGO:00300971830.012
mitotic cell cycleGO:0000278640.012
entrainment of circadian clock by photoperiodGO:004315310.012
regulation of bindingGO:005109830.012
regulation of epithelial to mesenchymal transitionGO:001071730.012
regulation of cellular macromolecule biosynthetic processGO:20001122220.012
regulation of protein catabolic processGO:004217610.012
neuron projection morphogenesisGO:00488121610.012
regulation of cellular carbohydrate metabolic processGO:001067540.012
response to unfolded proteinGO:000698620.012
membrane invaginationGO:001032410.012
double strand break repair via homologous recombinationGO:000072410.012
response to corticosteroidGO:003196010.012
cell motilityGO:00488702440.012
cellular response to dsrnaGO:007135910.012
striated muscle tissue developmentGO:00147061100.012
positive regulation of secretionGO:005104710.012
regulation of ion transmembrane transporter activityGO:003241220.012
negative regulation of cellular metabolic processGO:0031324770.012
amine metabolic processGO:000930820.012
positive regulation of cell activationGO:005086710.012
cognitionGO:005089010.012
cellular protein modification processGO:00064641000.012
protein homooligomerizationGO:005126030.011
actin polymerization or depolymerizationGO:000815420.011
taxisGO:00423301090.011
cellular process involved in reproduction in multicellular organismGO:0022412280.011
negative regulation of signalingGO:0023057960.011
germ line stem cell divisionGO:004207810.011
stem cell developmentGO:0048864820.011
cytoskeleton dependent cytokinesisGO:006164030.011
developmental maturationGO:0021700340.011
positive regulation of immune effector processGO:000269930.011
mitotic cell cycle processGO:1903047480.011
mitotic cell cycle embryonicGO:004544820.011
regulation of transporter activityGO:003240920.011
regulation of transmembrane transporter activityGO:002289820.011
cellular ketone metabolic processGO:0042180110.011
cellular response to organic substanceGO:00713101050.011
axonogenesisGO:00074091520.011
regulation of striated muscle contractionGO:000694220.011
cell cycle g2 m phase transitionGO:004483940.011
sensory organ developmentGO:00074233930.011
female gamete generationGO:0007292140.011
nucleic acid metabolic processGO:00903042440.011
Human
regulation of establishment of protein localization to plasma membraneGO:009000310.011
regulation of nitrogen compound metabolic processGO:00511712510.011
germ cell developmentGO:0007281220.011
membrane fusionGO:006102520.011
positive regulation of cellular metabolic processGO:0031325940.011
specification of symmetryGO:00097992040.011
regulation of synapse assemblyGO:005196330.011
mononuclear cell proliferationGO:003294310.011
cell cycle processGO:0022402530.011
stem cell proliferationGO:007208940.011
skeletal system developmentGO:00015011810.011
negative regulation of dna replicationGO:000815620.011
blood vessel developmentGO:00015682460.011
positive regulation of chromatin modificationGO:190331010.011
mitotic g2 dna damage checkpointGO:000709530.011
positive regulation of striated muscle tissue developmentGO:004584410.011
carbohydrate homeostasisGO:003350010.011
negative regulation of reproductive processGO:200024230.011
negative regulation of cell communicationGO:0010648960.011
response to glucocorticoidGO:005138410.011
establishment of synaptic vesicle localizationGO:009748010.011
nucleotide metabolic processGO:0009117280.011
positive regulation of jnk cascadeGO:004633030.011
tissue remodelingGO:004877140.011
b cell activationGO:004211320.011
regulation of cellular amine metabolic processGO:003323800.011
regulation of biosynthetic processGO:00098892500.011
negative regulation of intracellular protein transportGO:009031730.010
negative regulation of cell deathGO:0060548600.010
determination of bilateral symmetryGO:00098552040.010
cellular response to radiationGO:007147840.010
secondary metabolic processGO:001974830.010
response to woundingGO:00096111160.010
cell projection morphogenesisGO:00488582440.010
regulation of neurotransmitter secretionGO:004692810.010
regulation of glucose importGO:004632410.010
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.010
neurotransmitter secretionGO:000726920.010
positive regulation of cellular amine metabolic processGO:003324000.010
intracellular signal transductionGO:0035556850.010
regulation of response to cytokine stimulusGO:006075930.010
i kappab kinase nf kappab signalingGO:000724940.010
long chain fatty acid metabolic processGO:000167610.010
negative regulation of mapk cascadeGO:004340940.010
cilium morphogenesisGO:0060271850.010
cellular response to oxygen levelsGO:007145310.010
proteasomal protein catabolic processGO:001049820.010
muscle cell developmentGO:00550011150.010
positive regulation of cell adhesionGO:004578510.010
positive regulation of cellular amino acid metabolic processGO:004576400.010
cellular response to starvationGO:000926710.010
regulation of mitotic cell cycleGO:0007346250.010
regulation of microtubule cytoskeleton organizationGO:007050730.010
response to lipidGO:0033993600.010
regulation of erk1 and erk2 cascadeGO:007037240.010
response to biotic stimulusGO:0009607970.010
response to ketoneGO:190165410.010
response to temperature stimulusGO:0009266150.010
cellular response to topologically incorrect proteinGO:003596720.010
segmentationGO:0035282970.010
fatty acid biosynthetic processGO:000663340.010
symbiosis encompassing mutualism through parasitismGO:004440340.010
ubiquitin dependent protein catabolic processGO:000651130.010

top1l disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.030
nervous system diseaseDOID:86300.011
inherited metabolic disorderDOID:65500.011
disease of metabolismDOID:001466700.011
disease of cellular proliferationDOID:1456600.010