Danio rerio

7 known processes

adam8a

a disintegrin and metalloproteinase domain 8a

(Aliases: zgc:64059,si:zc217g15.7,MGC64059,adam8,reprolysin)

adam8a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to external stimulusGO:00096052640.386
Mouse
locomotionGO:00400113130.206
Mouse
myeloid cell differentiationGO:0030099860.174
angiogenesisGO:00015251580.142
Mouse
small molecule metabolic processGO:0044281770.140
blood vessel developmentGO:00015682460.131
Mouse
response to stressGO:00069502630.125
Mouse
regulation of multicellular organismal developmentGO:20000262230.125
Mouse
regulation of sequestering of calcium ionGO:005128240.125
localization of cellGO:00516742440.125
Mouse
central nervous system developmentGO:00074173870.119
maintenance of locationGO:005123540.118
generation of neuronsGO:00486993850.108
negative regulation of protein kinase activityGO:000646940.107
digestive tract morphogenesisGO:00485462310.107
regulation of multicellular organismal processGO:00512392770.104
Mouse
inflammatory responseGO:000695480.101
Mouse
larval developmentGO:000216420.094
cell migrationGO:00164772370.090
Mouse
response to chemicalGO:00422213200.090
Mouse
negative regulation of multicellular organismal processGO:0051241690.086
purine nucleoside monophosphate catabolic processGO:000912840.084
regulation of response to stimulusGO:00485832690.083
Mouse
negative regulation of cellular processGO:00485232830.083
Mouse
cellular biosynthetic processGO:00442492860.082
Mouse
cellular extravasationGO:004512310.078
Mouse
single organism metabolic processGO:00447102170.078
Mouse
homeostasis of number of cellsGO:0048872620.078
sensory organ developmentGO:00074233930.078
cellular response to organic substanceGO:00713101050.076
cellular nitrogen compound biosynthetic processGO:00442712180.074
Mouse
regulation of cell activationGO:005086510.074
Mouse
regulation of cellular amine metabolic processGO:003323800.073
nitrogen compound metabolic processGO:00068073190.071
Mouse
axon ensheathment in central nervous systemGO:003229120.070
organonitrogen compound metabolic processGO:1901564740.070
cell motilityGO:00488702440.069
Mouse
regulation of biological qualityGO:00650082630.068
Mouse
amine metabolic processGO:000930820.068
regulation of primary metabolic processGO:00800903110.068
Mouse
negative regulation of protein phosphorylationGO:000193340.068
cellular amine metabolic processGO:004410620.067
release of sequestered calcium ion into cytosolGO:005120930.067
vasculature developmentGO:00019442780.066
Mouse
regulation of signalingGO:00230512350.065
Mouse
regulation of cell shapeGO:000836010.063
cell substrate junction assemblyGO:000704420.061
negative regulation of biological processGO:00485193040.061
Mouse
single organism transportGO:00447652060.060
cellular component movementGO:00069283350.060
Mouse
regulation of catalytic activityGO:0050790550.060
Mouse
regulation of cellular amino acid metabolic processGO:000652100.058
tube morphogenesisGO:00352393490.058
cellular ketone metabolic processGO:0042180110.058
cellular amino acid metabolic processGO:000652070.057
positive regulation of cell adhesionGO:004578510.057
Mouse
organic acid metabolic processGO:0006082310.057
regulation of cell differentiationGO:00455951420.056
Mouse
cell surface receptor signaling pathwayGO:00071663250.055
cell substrate adhesionGO:003158940.054
multicellular organism growthGO:003526440.053
response to nutrientGO:000758430.052
immune system processGO:00023762410.050
Mouse
sequestering of metal ionGO:005123830.050
regulation of macromolecule metabolic processGO:00602553170.049
Mouse
blood vessel morphogenesisGO:00485142160.049
Mouse
cellular nitrogen compound metabolic processGO:00346412900.048
Mouse
hemopoiesisGO:00300971830.047
Mouse
head developmentGO:00603223030.046
regulation of cell developmentGO:00602841000.046
proteolysis involved in cellular protein catabolic processGO:005160330.046
regulation of peptidyl tyrosine phosphorylationGO:005073010.046
regulation of jak stat cascadeGO:004642530.045
regulation of cellular metabolic processGO:00313233200.045
Mouse
response to organic substanceGO:00100331530.044
regulation of anatomical structure morphogenesisGO:00226031300.044
taxisGO:00423301090.044
Mouse
macromolecule modificationGO:00434121110.043
Mouse
developmental growthGO:00485891660.043
immune system developmentGO:00025201910.043
Mouse
sequestering of calcium ionGO:005120830.042
positive regulation of blood circulationGO:190352420.042
organelle fusionGO:004828430.042
signal transductionGO:00071654550.042
Mouse
positive regulation of cellular amino acid metabolic processGO:004576400.042
camera type eye developmentGO:00430102220.041
negative regulation of cell communicationGO:0010648960.041
regulation of metabolic processGO:00192223590.041
Mouse
response to hormoneGO:0009725480.041
regulation of macromolecule biosynthetic processGO:00105562250.041
Mouse
negative regulation of sequestering of calcium ionGO:005128340.041
negative regulation of kinase activityGO:003367340.041
digestive system developmentGO:00551232890.040
neuron projection developmentGO:00311751800.040
agingGO:000756820.039
nucleic acid templated transcriptionGO:00976591810.039
Mouse
membrane fusionGO:006102520.038
stem cell differentiationGO:00488631170.038
cell matrix adhesionGO:000716040.037
negative regulation of developmental processGO:0051093650.037
positive regulation of catabolic processGO:000989640.037
Mouse
regulation of establishment of protein localizationGO:007020140.037
cognitionGO:005089010.036
regulation of localizationGO:00328791040.036
Mouse
protein import into nucleusGO:000660630.036
regulation of biosynthetic processGO:00098892500.036
Mouse
establishment of localizationGO:00512342440.035
positive regulation of cellular processGO:00485222010.035
Mouse
cellular response to nutrient levelsGO:003166920.035
regulation of cytoplasmic transportGO:190364940.034
adherens junction organizationGO:003433240.034
regulation of protein catabolic processGO:004217610.034
Mouse
regulation of multicellular organism growthGO:004001440.034
biological adhesionGO:0022610400.034
Mouse
positive regulation of map kinase activityGO:004340630.033
Mouse
regulation of cellular ketone metabolic processGO:001056570.033
cellular response to chemical stimulusGO:00708871570.033
Mouse
cellular amide metabolic processGO:004360340.033
regulation of metal ion transportGO:001095940.033
regulation of cell communicationGO:00106462320.032
Mouse
hematopoietic or lymphoid organ developmentGO:00485341910.032
Mouse
oxoacid metabolic processGO:0043436310.032
fin developmentGO:0033333770.032
organelle organizationGO:00069962270.032
transportGO:00068102200.032
response to endogenous stimulusGO:0009719830.031
embryonic organ developmentGO:00485683810.031
brain developmentGO:00074202930.031
erythrocyte differentiationGO:0030218540.031
carboxylic acid metabolic processGO:0019752220.030
establishment of protein localization to organelleGO:007259440.030
response to abiotic stimulusGO:00096281220.030
positive regulation of transportGO:005105020.029
regulation of reproductive processGO:200024140.029
regulation of developmental processGO:00507932470.029
Mouse
cellular macromolecule metabolic processGO:00442603910.028
Mouse
negative regulation of secretion by cellGO:190353120.028
central nervous system myelinationGO:002201020.028
cellular aromatic compound metabolic processGO:00067252950.028
Mouse
system processGO:00030081850.027
atp catabolic processGO:000620040.027
rna metabolic processGO:00160702190.027
Mouse
cell morphogenesis involved in neuron differentiationGO:00486671630.026
epithelial tube morphogenesisGO:00605621480.026
cellular component morphogenesisGO:00329893360.026
Mouse
convergent extensionGO:00600261180.026
single organism localizationGO:19025782250.025
purine ribonucleoside monophosphate catabolic processGO:000916940.025
regulation of nitrogen compound metabolic processGO:00511712510.025
Mouse
erythrocyte homeostasisGO:0034101550.025
cell morphogenesisGO:00009022890.025
Mouse
ribonucleoside monophosphate catabolic processGO:000915840.025
positive regulation of cytosolic calcium ion concentrationGO:000720440.024
phagocytosisGO:000690930.024
homeostatic processGO:00425921420.024
Mouse
growthGO:00400071740.024
development of primary female sexual characteristicsGO:004654540.024
muscle structure developmentGO:00610611960.024
establishment of protein localization to plasma membraneGO:009000210.024
skeletal system developmentGO:00015011810.023
regulation of cell adhesionGO:0030155150.023
Mouse
cellular response to hormone stimulusGO:0032870390.023
negative regulation of metabolic processGO:0009892860.023
protein localization to plasma membraneGO:007265910.023
stem cell developmentGO:0048864820.023
heterocycle biosynthetic processGO:00181302150.023
Mouse
positive regulation of cell activationGO:005086710.023
Mouse
biosynthetic processGO:00090582940.022
Mouse
response to growth factorGO:0070848390.022
negative regulation of nitrogen compound metabolic processGO:0051172590.022
eye developmentGO:00016542770.022
neutrophil mediated immunityGO:000244610.022
protein importGO:001703830.022
ameboidal type cell migrationGO:00016671430.022
negative regulation of secretionGO:005104820.022
cellular response to extracellular stimulusGO:003166820.022
digestive tract developmentGO:00485652650.022
positive regulation of biological processGO:00485182530.021
Mouse
regulation of nucleic acid templated transcriptionGO:19035062130.021
Mouse
regulation of extrinsic apoptotic signaling pathwayGO:200123630.021
negative regulation of response to stimulusGO:00485851040.021
single organism cell adhesionGO:0098602290.021
Mouse
macromolecule biosynthetic processGO:00090592270.021
Mouse
modification dependent protein catabolic processGO:001994130.021
ras protein signal transductionGO:000726570.021
ion transportGO:00068111140.021
regulation of molecular functionGO:0065009700.021
Mouse
endosomal transportGO:001619720.021
regulation of intracellular signal transductionGO:1902531570.020
Mouse
single organism organelle organizationGO:19025891990.020
regulation of inflammatory responseGO:005072720.020
Mouse
somitogenesisGO:0001756870.020
tissue remodelingGO:004877140.020
Mouse
cellular protein catabolic processGO:004425740.020
cortical actin cytoskeleton organizationGO:003086610.020
cellular response to lipopolysaccharideGO:007122230.020
cellular response to endogenous stimulusGO:0071495680.020
synaptic vesicle localizationGO:009747910.020
female sex differentiationGO:004666040.020
oxidation reduction processGO:0055114410.020
positive regulation of cellular amine metabolic processGO:003324000.020
metal ion transportGO:0030001580.020
chemotaxisGO:00069351040.019
Mouse
regulation of protein localization to plasma membraneGO:190307610.019
nuclear transportGO:005116940.019
regulation of rna metabolic processGO:00512522240.019
Mouse
cellular localizationGO:0051641970.019
negative regulation of map kinase activityGO:004340720.019
myeloid cell homeostasisGO:0002262560.019
regulation of protein transportGO:005122330.019
cellular response to growth factor stimulusGO:0071363390.019
ubiquitin dependent protein catabolic processGO:000651130.019
negative regulation of defense responseGO:003134820.019
fin morphogenesisGO:0033334530.019
heart developmentGO:00075073130.019
extrinsic apoptotic signaling pathwayGO:009719130.019
regulation of calcium ion transportGO:005192420.019
organic substance biosynthetic processGO:19015762890.018
Mouse
negative regulation of protein serine threonine kinase activityGO:007190120.018
proteolysisGO:0006508380.018
anterior posterior pattern specificationGO:00099521520.018
negative regulation of neurogenesisGO:0050768200.018
neuron differentiationGO:00301823530.018
cellular response to external stimulusGO:007149620.018
response to external biotic stimulusGO:0043207970.018
regionalizationGO:00030022740.018
negative regulation of cytokine productionGO:000181810.018
primary neural tube formationGO:001402010.018
modification dependent macromolecule catabolic processGO:004363230.018
multicellular organismal response to stressGO:003355520.018
positive regulation of cytokine productionGO:000181920.018
Mouse
regulation of locomotionGO:0040012550.017
Mouse
single organism membrane fusionGO:004480120.017
positive regulation of apoptotic signaling pathwayGO:200123510.017
embryonic hemopoiesisGO:0035162530.017
negative regulation of cellular metabolic processGO:0031324770.017
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.017
hematopoietic progenitor cell differentiationGO:0002244230.017
meiotic nuclear divisionGO:000712640.017
cellular response to molecule of bacterial originGO:007121930.017
central nervous system neuron differentiationGO:0021953740.017
mononuclear cell proliferationGO:003294310.017
cellular response to starvationGO:000926710.016
regulation of erk1 and erk2 cascadeGO:007037240.016
positive regulation of macromolecule metabolic processGO:0010604930.016
Mouse
nucleocytoplasmic transportGO:000691340.016
lipid storageGO:001991510.016
protein targeting to membraneGO:000661210.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
cytosolic calcium ion transportGO:006040130.016
cellular response to radiationGO:007147840.016
axon developmentGO:00615641660.016
regulation of cellular biosynthetic processGO:00313262450.016
Mouse
female gonad developmentGO:000858540.015
response to drugGO:004249330.015
regulation of mrna splicing via spliceosomeGO:004802430.015
proteasomal protein catabolic processGO:001049820.015
apoptotic processGO:00069151160.015
Mouse
heart morphogenesisGO:00030071560.015
positive regulation of cellular component biogenesisGO:004408930.015
neuron projection guidanceGO:0097485860.015
protein dephosphorylationGO:000647030.015
regulation of cellular extravasationGO:000269110.015
Mouse
response to lipidGO:0033993600.015
cytokinesisGO:000091030.015
single organism nuclear importGO:190259330.015
heterocycle metabolic processGO:00464832900.015
Mouse
mesenchymal cell developmentGO:0014031780.015
cell cycle g1 s phase transitionGO:004484310.015
regulation of protein metabolic processGO:0051246560.014
Mouse
leukocyte differentiationGO:0002521250.014
Mouse
regulation of cell morphogenesisGO:0022604420.014
behaviorGO:0007610740.014
protein localizationGO:0008104400.014
calcium ion transport into cytosolGO:006040230.014
positive regulation of cellular extravasationGO:000269310.014
Mouse
positive regulation of nucleoside metabolic processGO:004597910.014
negative regulation of myeloid cell differentiationGO:004563810.014
cellular response to stressGO:0033554620.014
cellular protein metabolic processGO:00442671290.014
Mouse
protein modification processGO:00362111000.014
Mouse
response to woundingGO:00096111160.014
Mouse
positive regulation of cell cycleGO:004578730.014
positive regulation of chromosome organizationGO:200125210.014
negative regulation of signalingGO:0023057960.014
activation of mapk activityGO:000018730.014
Mouse
morphogenesis of an epitheliumGO:00020093330.014
lymphangiogenesisGO:0001946250.014
gland developmentGO:00487321430.014
nucleobase containing small molecule metabolic processGO:0055086320.014
lipid metabolic processGO:0006629520.014
negative regulation of biosynthetic processGO:0009890550.014
sensory organ morphogenesisGO:00905962000.014
positive regulation of secretion by cellGO:190353210.014
organic cyclic compound metabolic processGO:19013603010.014
Mouse
regulation of gene expressionGO:00104682650.014
Mouse
protein secretionGO:000930610.014
cell proliferationGO:0008283800.014
regulation of cell motilityGO:2000145460.014
Mouse
carbohydrate derivative metabolic processGO:1901135610.014
pancreas developmentGO:0031016840.014
negative regulation of immune responseGO:005077720.014
hematopoietic stem cell differentiationGO:0060218200.014
defense response to fungusGO:005083220.014
regulation of proteolysisGO:0030162240.014
Mouse
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.013
negative regulation of catalytic activityGO:0043086210.013
stem cell maintenanceGO:001982740.013
negative regulation of leukocyte differentiationGO:190210610.013
regulation of cellular component organizationGO:0051128860.013
neuron developmentGO:00486662620.013
hormone transportGO:000991420.013
regulation of protein targetingGO:190353320.013
muscle organ developmentGO:00075171010.013
nucleoside monophosphate catabolic processGO:000912540.013
embryo development ending in birth or egg hatchingGO:00097922710.013
cellular macromolecule biosynthetic processGO:00346452240.013
Mouse
guanosine containing compound metabolic processGO:190106840.013
hepaticobiliary system developmentGO:0061008980.013
wound healingGO:0042060900.013
positive regulation of secretionGO:005104710.013
circulatory system processGO:0003013870.013
nucleic acid metabolic processGO:00903042440.013
Mouse
regulation of nucleocytoplasmic transportGO:004682220.013
small gtpase mediated signal transductionGO:000726480.013
neural crest cell developmentGO:0014032620.013
response to alkaloidGO:004327920.012
leukocyte mediated cytotoxicityGO:000190910.012
appendage morphogenesisGO:0035107560.012
organic cyclic compound biosynthetic processGO:19013622230.012
Mouse
somatic muscle developmentGO:000752540.012
positive regulation of nucleotide catabolic processGO:003081310.012
negative regulation of signal transductionGO:0009968940.012
locomotory behaviorGO:0007626340.012
receptor internalizationGO:003162320.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.012
cell substrate adherens junction assemblyGO:000704510.012
somite developmentGO:0061053960.012
cell morphogenesis involved in differentiationGO:00009041950.012
reactive oxygen species biosynthetic processGO:190340910.012
pectoral fin developmentGO:0033339500.012
embryonic heart tube developmentGO:00350501330.012
cell part morphogenesisGO:00329902460.012
regulation of cell deathGO:00109411030.012
Mouse
cellular response to reactive oxygen speciesGO:003461420.012
hormone secretionGO:004687920.012
positive regulation of purine nucleotide catabolic processGO:003312310.012
axonal defasciculationGO:000741420.012
gliogenesisGO:0042063450.012
regulation of response to external stimulusGO:0032101310.012
Mouse
protein metabolic processGO:00195381830.012
negative regulation of mapk cascadeGO:004340940.012
blood circulationGO:0008015870.012
regulation of protein complex assemblyGO:004325430.012
gtp catabolic processGO:000618420.012
response to amino acidGO:004320020.012
negative regulation of macromolecule metabolic processGO:0010605760.012
deathGO:00162651210.012
Mouse
erk1 and erk2 cascadeGO:007037140.012
intracellular signal transductionGO:0035556850.012
Mouse
symbiosis encompassing mutualism through parasitismGO:004440340.012
cell cycleGO:0007049930.012
nucleobase containing compound biosynthetic processGO:00346542050.012
Mouse
regulation of jun kinase activityGO:004350630.012
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.011
positive regulation of jak stat cascadeGO:004642720.011
cell projection organizationGO:00300302840.011
nuclear importGO:005117030.011
neuroblast proliferationGO:000740520.011
negative regulation of cellular biosynthetic processGO:0031327550.011
negative regulation of developmental growthGO:004864090.011
chordate embryonic developmentGO:00430092710.011
g1 s transition of mitotic cell cycleGO:000008210.011
cell adhesionGO:0007155400.011
Mouse
regulation of intracellular protein transportGO:003315730.011
convergent extension involved in gastrulationGO:0060027710.011
transmembrane transportGO:00550851200.011
regulation of purine nucleotide catabolic processGO:003312120.011
smooth muscle contractionGO:000693920.011
regulation of cellular component movementGO:0051270550.011
Mouse
cortical cytoskeleton organizationGO:003086510.011
positive regulation of histone modificationGO:003105810.011
gene expressionGO:00104672520.011
Mouse
segmentationGO:0035282970.011
positive regulation of cellular catabolic processGO:003133130.011
Mouse
regulation of programmed cell deathGO:00430671010.011
Mouse
regulation of nucleotide catabolic processGO:003081120.011
negative regulation of multi organism processGO:004390130.011
regulation of hydrolase activityGO:0051336280.011
enzyme linked receptor protein signaling pathwayGO:00071671060.010
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.010
organic substance transportGO:0071702580.010
startle responseGO:000196440.010
regulation of protein modification processGO:0031399290.010
Mouse
establishment of blood brain barrierGO:006085620.010
phagocytosis engulfmentGO:000691110.010
dna modificationGO:000630480.010
negative regulation of cellular protein metabolic processGO:0032269160.010
cellular response to steroid hormone stimulusGO:0071383310.010
positive regulation of programmed cell deathGO:0043068290.010
Mouse
chemosensory behaviorGO:000763510.010
regulation of cell substrate adhesionGO:001081010.010
neuron remodelingGO:001632210.010
tube closureGO:006060610.010
gastrulationGO:00073692080.010
protein polymerizationGO:005125840.010
cellular component assembly involved in morphogenesisGO:00109271070.010
regulation of hormone secretionGO:004688320.010
heart processGO:0003015710.010
spermatid developmentGO:000728620.010
guanosine containing compound catabolic processGO:190106920.010
regulation of cytokine productionGO:000181730.010
Mouse
membrane organizationGO:0061024210.010
multicellular organismal macromolecule metabolic processGO:004425920.010
protein targeting to nucleusGO:004474430.010

adam8a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.070
immune system diseaseDOID:291400.019
cancerDOID:16200.018
disease of cellular proliferationDOID:1456600.018
disease of metabolismDOID:001466700.013
inherited metabolic disorderDOID:65500.013
eye and adnexa diseaseDOID:149200.013
nervous system diseaseDOID:86300.013
sensory system diseaseDOID:005015500.013
eye diseaseDOID:561400.013
retinal diseaseDOID:567900.012