IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

nkx2.3

NK2 transcription factor related 3

(Aliases: nk2.3,nkx2-3)

Entrez: 30698
Ensembl: ENSDARG00000039095
ZFIN: ZDB-GENE-990415-178
UniProtKB: Q98871

Process Predictions
Disease Predictions

nkx2.3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chordate embryonic development	GO:0043009	271	0.953	Zebrafish
cellular macromolecule biosynthetic process	GO:0034645	224	0.923	Mouse Worm
regulation of multicellular organismal process	GO:0051239	277	0.819	Zebrafish
sympathetic nervous system development	GO:0048485	3	0.781
embryo development ending in birth or egg hatching	GO:0009792	271	0.778	Zebrafish
embryonic organ morphogenesis	GO:0048562	274	0.775	Zebrafish
autonomic nervous system development	GO:0048483	19	0.750
cellular biosynthetic process	GO:0044249	286	0.750	Mouse Worm
macromolecule biosynthetic process	GO:0009059	227	0.736	Mouse Worm
regulation of gene expression	GO:0010468	265	0.726	Mouse Worm
regulation of primary metabolic process	GO:0080090	311	0.674	Mouse Worm
cellular aromatic compound metabolic process	GO:0006725	295	0.658	Mouse Worm
kidney development	GO:0001822	92	0.657
regulation of cellular biosynthetic process	GO:0031326	245	0.657	Mouse Worm
embryonic skeletal system morphogenesis	GO:0048704	93	0.656
renal system development	GO:0072001	94	0.635
regulation of nucleic acid templated transcription	GO:1903506	213	0.634	Mouse Worm
negative regulation of cellular biosynthetic process	GO:0031327	55	0.631
organic substance biosynthetic process	GO:1901576	289	0.630	Mouse Worm
skin development	GO:0043588	54	0.625
embryonic organ development	GO:0048568	381	0.616	Zebrafish
heterocycle metabolic process	GO:0046483	290	0.615	Mouse Worm
central nervous system development	GO:0007417	387	0.601	Zebrafish
biosynthetic process	GO:0009058	294	0.596	Mouse Worm
transcription dna templated	GO:0006351	181	0.593	Mouse Worm
organic cyclic compound metabolic process	GO:1901360	301	0.589	Mouse Worm
regulation of macromolecule metabolic process	GO:0060255	317	0.587	Mouse Worm
programmed cell death	GO:0012501	119	0.583
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.577	Mouse Worm
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.571	Mouse Worm
stem cell proliferation	GO:0072089	4	0.556
pronephric nephron development	GO:0039019	14	0.538
cellular nitrogen compound metabolic process	GO:0034641	290	0.532	Mouse Worm
digestive tract development	GO:0048565	265	0.527	Mouse Worm
regulation of nitrogen compound metabolic process	GO:0051171	251	0.519	Mouse Worm
embryonic skeletal system development	GO:0048706	97	0.517
digestive system development	GO:0055123	289	0.496	Mouse Worm
nucleic acid metabolic process	GO:0090304	244	0.490	Mouse Worm
cell fate specification	GO:0001708	68	0.481	Zebrafish
otic vesicle morphogenesis	GO:0071600	34	0.462
mesenchymal cell proliferation	GO:0010463	1	0.456
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.446
positive regulation of cellular metabolic process	GO:0031325	94	0.436	Mouse Worm
hemopoiesis	GO:0030097	183	0.427	Mouse
regulation of transcription dna templated	GO:0006355	213	0.417	Mouse Worm
gland development	GO:0048732	143	0.412	Zebrafish Mouse
morphogenesis of an epithelium	GO:0002009	333	0.410	Zebrafish
type b pancreatic cell development	GO:0003323	4	0.407
regulation of stem cell proliferation	GO:0072091	2	0.405
organic cyclic compound biosynthetic process	GO:1901362	223	0.402	Mouse Worm
blood circulation	GO:0008015	87	0.400
ear development	GO:0043583	127	0.399
cellular macromolecule metabolic process	GO:0044260	391	0.397	Mouse Worm
regulation of multicellular organismal development	GO:2000026	223	0.393	Zebrafish
larval development	GO:0002164	2	0.388
establishment of localization	GO:0051234	244	0.384	Worm
negative regulation of biological process	GO:0048519	304	0.375
positive regulation of cellular process	GO:0048522	201	0.375	Mouse Worm
urogenital system development	GO:0001655	97	0.373
negative regulation of cellular process	GO:0048523	283	0.372
nucleobase containing compound metabolic process	GO:0006139	274	0.366	Mouse Worm
regulation of cellular metabolic process	GO:0031323	320	0.365	Mouse Worm
rna biosynthetic process	GO:0032774	181	0.361	Mouse Worm
nitrogen compound metabolic process	GO:0006807	319	0.357	Mouse Worm
vestibular receptor cell development	GO:0060118	3	0.338
endocrine pancreas development	GO:0031018	27	0.335	Zebrafish
regulation of blood coagulation	GO:0030193	1	0.332
regionalization	GO:0003002	274	0.326
glomerulus development	GO:0032835	27	0.314
positive regulation of stem cell proliferation	GO:2000648	1	0.308
embryonic viscerocranium morphogenesis	GO:0048703	52	0.304
regulation of biosynthetic process	GO:0009889	250	0.301	Mouse Worm
aromatic compound biosynthetic process	GO:0019438	217	0.300	Mouse Worm
axonogenesis	GO:0007409	152	0.294	Zebrafish
blood vessel development	GO:0001568	246	0.293
nucleobase containing compound biosynthetic process	GO:0034654	205	0.290	Mouse Worm
endocrine system development	GO:0035270	65	0.290	Zebrafish
otic placode formation	GO:0043049	23	0.282
system process	GO:0003008	185	0.281
transcription from rna polymerase ii promoter	GO:0006366	80	0.277	Mouse Worm
nucleic acid templated transcription	GO:0097659	181	0.271	Mouse Worm
pancreas development	GO:0031016	84	0.267	Zebrafish
heterocycle biosynthetic process	GO:0018130	215	0.266	Mouse Worm
retinal ganglion cell axon guidance	GO:0031290	35	0.266
head development	GO:0060322	303	0.264
tube morphogenesis	GO:0035239	349	0.264	Zebrafish Mouse
striated muscle tissue development	GO:0014706	110	0.259	Zebrafish
aging	GO:0007568	2	0.256
generation of neurons	GO:0048699	385	0.253	Zebrafish
epidermis development	GO:0008544	48	0.253
regulation of wound healing	GO:0061041	2	0.252
positive regulation of rna metabolic process	GO:0051254	59	0.246	Mouse Worm
sensory organ morphogenesis	GO:0090596	200	0.240
positive regulation of biological process	GO:0048518	253	0.233	Mouse Worm
cell fate commitment	GO:0045165	99	0.232	Zebrafish
spinal cord oligodendrocyte cell fate specification	GO:0021530	2	0.231	Zebrafish
inner ear morphogenesis	GO:0042472	63	0.228
epidermal cell fate specification	GO:0009957	4	0.228
negative regulation of metabolic process	GO:0009892	86	0.222
regulation of organ morphogenesis	GO:2000027	35	0.220	Zebrafish
mesenchyme development	GO:0060485	127	0.218
positive regulation of epithelial cell proliferation	GO:0050679	1	0.217
neuron projection development	GO:0031175	180	0.217	Zebrafish
dorsal ventral pattern formation	GO:0009953	125	0.216
skeletal system development	GO:0001501	181	0.216
regulation of cell proliferation	GO:0042127	37	0.215	Mouse
otic vesicle formation	GO:0030916	27	0.213
neuron development	GO:0048666	262	0.211	Zebrafish
positive regulation of map kinase activity	GO:0043406	3	0.208
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.207
regulation of macromolecule biosynthetic process	GO:0010556	225	0.204	Mouse Worm
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.203	Mouse Worm
neuron projection morphogenesis	GO:0048812	161	0.203	Zebrafish
regulation of cardiac chamber formation	GO:1901210	2	0.203	Zebrafish
positive regulation of biosynthetic process	GO:0009891	68	0.200	Mouse Worm
regulation of rna biosynthetic process	GO:2001141	213	0.199	Mouse Worm
hormone secretion	GO:0046879	2	0.198
regulation of hormone secretion	GO:0046883	2	0.197
immune system process	GO:0002376	241	0.196	Mouse
optomotor response	GO:0071632	1	0.196
ectodermal placode morphogenesis	GO:0071697	32	0.194
regulation of metabolic process	GO:0019222	359	0.191	Mouse Worm
regulation of programmed cell death	GO:0043067	101	0.177
regulation of cell communication	GO:0010646	232	0.177
muscle tissue development	GO:0060537	110	0.173	Zebrafish
lymph vessel development	GO:0001945	27	0.172
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.171
angiogenesis	GO:0001525	158	0.169
pronephric glomerulus development	GO:0039021	13	0.167
neural tube development	GO:0021915	62	0.167	Zebrafish
inner ear development	GO:0048839	126	0.166
retina development in camera type eye	GO:0060041	146	0.166
negative regulation of gene expression	GO:0010629	65	0.165
oxoacid metabolic process	GO:0043436	31	0.164
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.164	Mouse Worm
rna metabolic process	GO:0016070	219	0.164	Mouse Worm
eye development	GO:0001654	277	0.161
sensory organ development	GO:0007423	393	0.161
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.160	Zebrafish
central nervous system myelin formation	GO:0032289	1	0.159
circulatory system process	GO:0003013	87	0.159
death	GO:0016265	121	0.158
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.158	Mouse Worm
locomotion	GO:0040011	313	0.157	Zebrafish Mouse
positive regulation of cellular biosynthetic process	GO:0031328	68	0.156	Mouse Worm
response to chemical	GO:0042221	320	0.155	Zebrafish
regulation of rna metabolic process	GO:0051252	224	0.155	Mouse Worm
anterior posterior pattern specification	GO:0009952	152	0.154
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.154	Mouse Worm
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.154
cell migration	GO:0016477	237	0.152	Zebrafish Mouse
hard palate development	GO:0060022	4	0.151
photoreceptor cell fate commitment	GO:0046552	1	0.150
odontogenesis of dentin containing tooth	GO:0042475	1	0.148	Mouse
cell motility	GO:0048870	244	0.148	Zebrafish Mouse
regulation of apoptotic process	GO:0042981	98	0.147
cell proliferation	GO:0008283	80	0.146	Zebrafish Mouse
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.144
neural tube patterning	GO:0021532	33	0.144
small molecule metabolic process	GO:0044281	77	0.144
neural crest cell differentiation	GO:0014033	72	0.144
meiotic chromosome segregation	GO:0045132	3	0.143
regulation of stem cell differentiation	GO:2000736	4	0.141
rostrocaudal neural tube patterning	GO:0021903	29	0.140
positive regulation of gene expression	GO:0010628	71	0.140	Mouse Worm
cartilage condensation	GO:0001502	3	0.139
vestibular receptor cell differentiation	GO:0060114	3	0.138
mesoderm development	GO:0007498	88	0.137
cardiac chamber formation	GO:0003207	4	0.136	Zebrafish
negative regulation of macromolecule metabolic process	GO:0010605	76	0.135
epidermal cell differentiation	GO:0009913	36	0.134
oligodendrocyte cell fate specification	GO:0021778	4	0.134	Zebrafish
positive regulation of mesenchymal cell proliferation	GO:0002053	1	0.133
epithelial tube morphogenesis	GO:0060562	148	0.131	Zebrafish
cell projection organization	GO:0030030	284	0.130	Zebrafish
nerve development	GO:0021675	45	0.129
response to oxygen levels	GO:0070482	25	0.129
negative regulation of stem cell differentiation	GO:2000737	2	0.127
midbrain hindbrain boundary development	GO:0030917	23	0.127
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.126	Mouse Worm
positive regulation of metabolic process	GO:0009893	108	0.125	Mouse Worm
positive regulation of macromolecule metabolic process	GO:0010604	93	0.125	Mouse Worm
negative regulation of biosynthetic process	GO:0009890	55	0.124
stem cell differentiation	GO:0048863	117	0.121
cellular ketone metabolic process	GO:0042180	11	0.120
regulation of hemostasis	GO:1900046	1	0.119
photoreceptor cell differentiation	GO:0046530	55	0.119
developmental programmed cell death	GO:0010623	4	0.119
peptide transport	GO:0015833	1	0.119
negative regulation of transcription dna templated	GO:0045892	45	0.117
morphogenesis of a branching structure	GO:0001763	21	0.116
neural crest cell development	GO:0014032	62	0.115
water homeostasis	GO:0030104	4	0.115
foregut morphogenesis	GO:0007440	4	0.115
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.113
apoptotic process involved in morphogenesis	GO:0060561	2	0.113
eye morphogenesis	GO:0048592	144	0.112
cell death	GO:0008219	121	0.112
positive regulation of signal transduction	GO:0009967	56	0.111
positive regulation of rna biosynthetic process	GO:1902680	57	0.111	Mouse Worm
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.110
type b pancreatic cell differentiation	GO:0003309	8	0.110
cell morphogenesis involved in differentiation	GO:0000904	195	0.110	Zebrafish
neuron fate specification	GO:0048665	20	0.109
cranial ganglion development	GO:0061550	3	0.106
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.105
organonitrogen compound metabolic process	GO:1901564	74	0.105
retina morphogenesis in camera type eye	GO:0060042	79	0.104
specification of symmetry	GO:0009799	204	0.104	Zebrafish
regulation of anatomical structure morphogenesis	GO:0022603	130	0.103	Zebrafish
hatching gland development	GO:0048785	3	0.102
appendage morphogenesis	GO:0035107	56	0.101
neuron differentiation	GO:0030182	353	0.101	Zebrafish
stem cell development	GO:0048864	82	0.100
hematopoietic stem cell differentiation	GO:0060218	20	0.099
neural crest cell migration	GO:0001755	42	0.097
forebrain development	GO:0030900	96	0.096
single organism metabolic process	GO:0044710	217	0.096	Mouse
negative regulation of cellular metabolic process	GO:0031324	77	0.095
response to hypoxia	GO:0001666	25	0.093
thyroid gland development	GO:0030878	12	0.092	Zebrafish
localization of cell	GO:0051674	244	0.091	Zebrafish Mouse
pronephros development	GO:0048793	69	0.091
myelin assembly	GO:0032288	1	0.090
homeostatic process	GO:0042592	142	0.089	Mouse
regulation of reproductive process	GO:2000241	4	0.089
cellular component movement	GO:0006928	335	0.089	Zebrafish Mouse
gene expression	GO:0010467	252	0.088	Mouse Worm
regulation of biological quality	GO:0065008	263	0.088	Mouse
ectodermal placode formation	GO:0060788	26	0.088
positive regulation of epithelial cell differentiation	GO:0030858	2	0.087
apoptotic process	GO:0006915	116	0.085
regulation of autophagy	GO:0010506	3	0.085
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.085
cellular protein metabolic process	GO:0044267	129	0.084
cell projection morphogenesis	GO:0048858	244	0.084	Zebrafish
cell fate specification involved in pattern specification	GO:0060573	3	0.083
otic vesicle development	GO:0071599	42	0.083
intracellular steroid hormone receptor signaling pathway	GO:0030518	5	0.083
cell cell signaling	GO:0007267	52	0.082
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.082	Mouse Worm
response to abiotic stimulus	GO:0009628	122	0.081
branching morphogenesis of an epithelial tube	GO:0048754	15	0.081
forebrain neuron fate commitment	GO:0021877	1	0.081
neuron projection guidance	GO:0097485	86	0.080	Zebrafish
patterning of blood vessels	GO:0001569	15	0.080
brain development	GO:0007420	293	0.079
positive regulation of transcription dna templated	GO:0045893	57	0.078	Mouse Worm
hormone transport	GO:0009914	2	0.077
inner ear receptor cell differentiation	GO:0060113	29	0.077
cranial nerve development	GO:0021545	42	0.076
embryonic limb morphogenesis	GO:0030326	2	0.076
auditory receptor cell fate specification	GO:0042667	2	0.075
regulation of cell activation	GO:0050865	1	0.074
heart jogging	GO:0003146	40	0.074
lipid biosynthetic process	GO:0008610	22	0.074
negative regulation of striated muscle tissue development	GO:0045843	2	0.072
regulation of hormone levels	GO:0010817	21	0.072
regulation of protein metabolic process	GO:0051246	56	0.071
autophagy	GO:0006914	4	0.071
macromolecule modification	GO:0043412	111	0.070
inner ear receptor cell fate commitment	GO:0060120	4	0.070
response to external stimulus	GO:0009605	264	0.069	Zebrafish
amine metabolic process	GO:0009308	2	0.069
single organism biosynthetic process	GO:0044711	71	0.069
intracellular receptor signaling pathway	GO:0030522	30	0.069
camera type eye photoreceptor cell differentiation	GO:0060219	19	0.068
ectodermal placode development	GO:0071696	37	0.068
regulation of epithelial cell proliferation	GO:0050678	3	0.068
regulation of cellular amine metabolic process	GO:0033238	0	0.067
pancreatic d cell differentiation	GO:0003311	2	0.067
regulation of mesenchymal cell proliferation	GO:0010464	1	0.067
pancreatic a cell development	GO:0003322	2	0.067
ameboidal type cell migration	GO:0001667	143	0.066
single organism localization	GO:1902578	225	0.066
carboxylic acid metabolic process	GO:0019752	22	0.066
heart contraction	GO:0060047	71	0.066
morphogenesis of an epithelial fold	GO:0060571	1	0.066
catechol containing compound metabolic process	GO:0009712	2	0.065
skeletal system morphogenesis	GO:0048705	102	0.065
cell morphogenesis	GO:0000902	289	0.064	Zebrafish
meiosis i	GO:0007127	1	0.064
blood vessel morphogenesis	GO:0048514	216	0.064
positive regulation of cellular catabolic process	GO:0031331	3	0.064
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.064
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.064
positive regulation of response to stimulus	GO:0048584	80	0.064
stem cell maintenance	GO:0019827	4	0.064
regulation of neurotransmitter transport	GO:0051588	1	0.064
intracellular signal transduction	GO:0035556	85	0.064
mesenchymal cell development	GO:0014031	78	0.063
appendage development	GO:0048736	80	0.062
phosphatidylinositol 3 kinase signaling	GO:0014065	2	0.062
ventral spinal cord development	GO:0021517	35	0.062	Zebrafish
notochord cell differentiation	GO:0060034	18	0.062
camera type eye development	GO:0043010	222	0.061
regulation of signaling	GO:0023051	235	0.061
odontogenesis	GO:0042476	9	0.061	Mouse
determination of ventral identity	GO:0048264	21	0.060
blood coagulation	GO:0007596	12	0.060
auditory receptor cell fate commitment	GO:0009912	4	0.060
regulation of response to stimulus	GO:0048583	269	0.060
vasculature development	GO:0001944	278	0.060
central nervous system myelination	GO:0022010	2	0.060
apoptotic process involved in development	GO:1902742	2	0.060
immune system development	GO:0002520	191	0.059	Mouse
glandular epithelial cell differentiation	GO:0002067	9	0.059
glomerulus vasculature development	GO:0072012	2	0.058
regulation of vascular permeability	GO:0043114	5	0.057
negative regulation of rna biosynthetic process	GO:1902679	45	0.057
response to external biotic stimulus	GO:0043207	97	0.057
glycerophospholipid biosynthetic process	GO:0046474	1	0.057
positive regulation of dna metabolic process	GO:0051054	1	0.057
mesenchymal cell differentiation	GO:0048762	87	0.057
cellular lipid metabolic process	GO:0044255	36	0.057	Mouse
chromosome organization	GO:0051276	31	0.056
signal transduction	GO:0007165	455	0.056
proepicardium development	GO:0003342	4	0.055
glial cell development	GO:0021782	20	0.055	Zebrafish
positive regulation of multicellular organismal process	GO:0051240	52	0.054
positive regulation of catabolic process	GO:0009896	4	0.054
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	17	0.054
bmp signaling pathway involved in heart development	GO:0061312	15	0.053
regulation of cell death	GO:0010941	103	0.053
lateral line ganglion development	GO:0048890	2	0.053
fourth ventricle development	GO:0021592	8	0.053
negative regulation of programmed cell death	GO:0043069	58	0.053
regulation of localization	GO:0032879	104	0.053
meiotic nuclear division	GO:0007126	4	0.052
taxis	GO:0042330	109	0.052	Zebrafish
response to organic substance	GO:0010033	153	0.052
connective tissue development	GO:0061448	99	0.052
somite development	GO:0061053	96	0.052
regulation of erk1 and erk2 cascade	GO:0070372	4	0.052
enteroendocrine cell differentiation	GO:0035883	9	0.052
single organism transport	GO:0044765	206	0.052
endodermal cell fate specification	GO:0001714	17	0.051
ear morphogenesis	GO:0042471	64	0.051
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	1	0.051
regulation of signal transduction	GO:0009966	225	0.051
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.050	Mouse Worm
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.050
camera type eye morphogenesis	GO:0048593	108	0.050
distal tubule development	GO:0072017	1	0.050
embryonic camera type eye development	GO:0031076	29	0.050
cellular response to starvation	GO:0009267	1	0.049
embryonic neurocranium morphogenesis	GO:0048702	15	0.049
cellular response to external stimulus	GO:0071496	2	0.049
protein modification process	GO:0036211	100	0.048
positive regulation of cell death	GO:0010942	29	0.048
gastrulation	GO:0007369	208	0.047
reflex	GO:0060004	2	0.047
floor plate development	GO:0033504	15	0.047	Zebrafish
negative regulation of multicellular organismal process	GO:0051241	69	0.047
organic acid metabolic process	GO:0006082	31	0.046
cellular response to nutrient levels	GO:0031669	2	0.046
neural plate pattern specification	GO:0060896	12	0.046
nephron development	GO:0072006	31	0.046
regulation of sodium ion transport	GO:0002028	2	0.045
epithelial cell differentiation	GO:0030855	116	0.045
embryonic heart tube development	GO:0035050	133	0.045	Zebrafish
reactive nitrogen species metabolic process	GO:2001057	0	0.045
positive regulation of transport	GO:0051050	2	0.045
regulation of cellular ketone metabolic process	GO:0010565	7	0.045
glucocorticoid metabolic process	GO:0008211	2	0.044
multicellular organismal water homeostasis	GO:0050891	1	0.044
positive regulation of secretion	GO:0051047	1	0.044
oocyte maturation	GO:0001556	4	0.044
positive regulation of cell cycle	GO:0045787	3	0.044
regulation of endothelial cell differentiation	GO:0045601	3	0.044
cellular response to chemical stimulus	GO:0070887	157	0.043
response to stress	GO:0006950	263	0.043
positive regulation of apoptotic process	GO:0043065	29	0.043
pharyngeal muscle development	GO:0043282	4	0.042	Worm
positive regulation of protein polymerization	GO:0032273	2	0.042
regulation of system process	GO:0044057	40	0.042
oligodendrocyte cell fate commitment	GO:0021779	5	0.042	Zebrafish
exocrine pancreas development	GO:0031017	28	0.041
cellular protein modification process	GO:0006464	100	0.041
cellular response to extracellular stimulus	GO:0031668	2	0.041
fin development	GO:0033333	77	0.041
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.041
phosphorus metabolic process	GO:0006793	109	0.041
ventral midline development	GO:0007418	13	0.041	Zebrafish
digestive tract mesoderm development	GO:0007502	1	0.041
maintenance of location	GO:0051235	4	0.040
protein metabolic process	GO:0019538	183	0.040
regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901213	15	0.040
regulation of neurotransmitter secretion	GO:0046928	1	0.040
cellular amine metabolic process	GO:0044106	2	0.040
positive regulation of cell proliferation	GO:0008284	15	0.040
regulation of bmp signaling pathway involved in heart jogging	GO:2000223	12	0.039
negative regulation of developmental process	GO:0051093	65	0.039
inner ear receptor cell development	GO:0060119	20	0.039
organism emergence from protective structure	GO:0071684	4	0.038
phosphatidylinositol mediated signaling	GO:0048015	2	0.038
phosphorylation	GO:0016310	69	0.038
embryonic camera type eye morphogenesis	GO:0048596	19	0.037
neurological system process	GO:0050877	62	0.037
exocrine system development	GO:0035272	28	0.037
olfactory bulb development	GO:0021772	4	0.037
regulation of metal ion transport	GO:0010959	4	0.037
negative regulation of secretion by cell	GO:1903531	2	0.037
kidney vasculature development	GO:0061440	2	0.036
glomerulus morphogenesis	GO:0072102	7	0.036
phagocytosis	GO:0006909	3	0.036
ganglion development	GO:0061548	5	0.036
embryonic hemopoiesis	GO:0035162	53	0.036
carbohydrate homeostasis	GO:0033500	1	0.036
negative regulation of phosphate metabolic process	GO:0045936	13	0.035
response to uv	GO:0009411	3	0.035
embryonic retina morphogenesis in camera type eye	GO:0060059	22	0.035
atrioventricular valve formation	GO:0003190	3	0.035
catecholamine metabolic process	GO:0006584	2	0.035
response to monosaccharide	GO:0034284	3	0.035
regulation of cell differentiation	GO:0045595	142	0.035
negative regulation of muscle tissue development	GO:1901862	2	0.035
response to light stimulus	GO:0009416	46	0.034
cell part morphogenesis	GO:0032990	246	0.034	Zebrafish
female sex differentiation	GO:0046660	4	0.034
muscle cell differentiation	GO:0042692	139	0.034	Zebrafish
hemostasis	GO:0007599	13	0.033
behavior	GO:0007610	74	0.033
floor plate formation	GO:0021508	12	0.033	Zebrafish
morphogenesis of an epithelial sheet	GO:0002011	49	0.033
positive regulation of embryonic development	GO:0040019	3	0.033
negative regulation of kinase activity	GO:0033673	4	0.033
developmental growth involved in morphogenesis	GO:0060560	86	0.033
positive regulation of programmed cell death	GO:0043068	29	0.033
regulation of response to extracellular stimulus	GO:0032104	1	0.032
nitric oxide metabolic process	GO:0046209	2	0.032
organophosphate metabolic process	GO:0019637	37	0.032
regulation of developmental process	GO:0050793	247	0.032	Zebrafish
midbrain development	GO:0030901	28	0.032
myotube cell development	GO:0014904	35	0.032
cardiogenic plate morphogenesis	GO:0003142	1	0.032
regulation of cellular protein metabolic process	GO:0032268	52	0.032
pectoral fin development	GO:0033339	50	0.032
positive regulation of neuron apoptotic process	GO:0043525	1	0.031
negative regulation of apoptotic process	GO:0043066	55	0.031
epithelial to mesenchymal transition	GO:0001837	21	0.031
cerebellum formation	GO:0021588	2	0.031
negative regulation of response to stimulus	GO:0048585	104	0.031
pancreatic d cell development	GO:0003324	1	0.031
gliogenesis	GO:0042063	45	0.031	Zebrafish
chemosensory behavior	GO:0007635	1	0.031
muscle structure development	GO:0061061	196	0.031	Zebrafish Worm
lateral line nerve glial cell development	GO:0048937	6	0.031
embryonic pattern specification	GO:0009880	44	0.030
axon ensheathment in central nervous system	GO:0032291	2	0.030
pericardium development	GO:0060039	1	0.030
positive regulation of gastrulation	GO:2000543	2	0.030
regulation of binding	GO:0051098	3	0.030
atrial cardiac muscle cell differentiation	GO:0055011	5	0.030
macroautophagy	GO:0016236	1	0.030
axon guidance	GO:0007411	86	0.030	Zebrafish
spinal cord development	GO:0021510	46	0.030	Zebrafish
cellular response to lipopolysaccharide	GO:0071222	3	0.029
optic cup morphogenesis involved in camera type eye development	GO:0002072	7	0.029
negative regulation of epithelial to mesenchymal transition	GO:0010719	1	0.029
cellular response to stress	GO:0033554	62	0.029
interspecies interaction between organisms	GO:0044419	4	0.029
trigeminal nerve development	GO:0021559	3	0.029
response to decreased oxygen levels	GO:0036293	25	0.029
glucose homeostasis	GO:0042593	1	0.029
establishment of localization in cell	GO:0051649	77	0.028
positive regulation of protein metabolic process	GO:0051247	23	0.028
hair cell differentiation	GO:0035315	32	0.028
negative regulation of rna metabolic process	GO:0051253	48	0.028
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.028
positive regulation of endothelial cell differentiation	GO:0045603	2	0.028
response to glucose	GO:0009749	3	0.028
myotube differentiation	GO:0014902	45	0.028
neuroblast differentiation	GO:0014016	1	0.028
embryonic heart tube morphogenesis	GO:0003143	108	0.028	Zebrafish
glycerolipid biosynthetic process	GO:0045017	1	0.028
cell differentiation in spinal cord	GO:0021515	40	0.028	Zebrafish
response to alkaloid	GO:0043279	2	0.028
cranial suture morphogenesis	GO:0060363	1	0.027
meiotic cell cycle process	GO:1903046	3	0.027
positive regulation of secretion by cell	GO:1903532	1	0.027
embryonic digestive tract morphogenesis	GO:0048557	3	0.027
limb bud formation	GO:0060174	2	0.027
response to carbohydrate	GO:0009743	3	0.027
neural plate anterior posterior regionalization	GO:0021999	8	0.027
metencephalon development	GO:0022037	27	0.027
regulation of cell motility	GO:2000145	46	0.027
cell projection assembly	GO:0030031	64	0.027
retinal cone cell differentiation	GO:0042670	12	0.027
endocardium formation	GO:0060214	1	0.026
muscle organ development	GO:0007517	101	0.026	Worm
multicellular organism growth	GO:0035264	4	0.026
erk1 and erk2 cascade	GO:0070371	4	0.026
lipid metabolic process	GO:0006629	52	0.026	Mouse
regulation of multicellular organism growth	GO:0040014	4	0.026
response to bacterium	GO:0009617	58	0.026
regulation of dna templated transcription elongation	GO:0032784	3	0.026
hindbrain formation	GO:0021576	3	0.026

nkx2.3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.156

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