Danio rerio

58 known processes

leo1

Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

(Aliases: zgc:77374,MGC77374)

leo1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryo development ending in birth or egg hatchingGO:00097922710.840
larval developmentGO:000216420.759
Worm
nitrogen compound metabolic processGO:00068073190.610
chordate embryonic developmentGO:00430092710.478
regulation of multicellular organismal developmentGO:20000262230.465
regulation of metabolic processGO:00192223590.401
rna metabolic processGO:00160702190.321
transportGO:00068102200.314
Worm
regulation of cellular metabolic processGO:00313233200.307
regulation of primary metabolic processGO:00800903110.273
regulation of multicellular organismal processGO:00512392770.273
Worm
immune system processGO:00023762410.268
heart developmentGO:00075073130.254
signal transductionGO:00071654550.248
cellular macromolecule metabolic processGO:00442603910.245
locomotionGO:00400113130.244
Worm
establishment of localizationGO:00512342440.225
Worm
central nervous system developmentGO:00074173870.218
alternative mrna splicing via spliceosomeGO:000038010.216
negative regulation of cellular processGO:00485232830.206
nucleobase containing compound metabolic processGO:00061392740.205
meiotic nuclear divisionGO:000712640.201
multicellular organism growthGO:003526440.196
Worm
cell surface receptor signaling pathwayGO:00071663250.187
positive regulation of nitrogen compound metabolic processGO:0051173690.175
heterocycle metabolic processGO:00464832900.174
synaptic growth at neuromuscular junctionGO:005112420.171
cellular nitrogen compound metabolic processGO:00346412900.167
regulation of macromolecule metabolic processGO:00602553170.160
regulation of developmental processGO:00507932470.159
Worm
organic cyclic compound metabolic processGO:19013603010.153
lipid storageGO:001991510.143
organelle organizationGO:00069962270.142
negative regulation of metabolic processGO:0009892860.139
hematopoietic or lymphoid organ developmentGO:00485341910.127
cellular component movementGO:00069283350.127
gene expressionGO:00104672520.127
blood vessel morphogenesisGO:00485142160.125
agingGO:000756820.124
regulation of meiotic cell cycleGO:005144510.124
macromolecule biosynthetic processGO:00090592270.121
regulation of rna metabolic processGO:00512522240.120
regulation of signal transductionGO:00099662250.117
mitotic cell cycleGO:0000278640.116
maintenance of locationGO:005123540.112
establishment of protein localization to organelleGO:007259440.112
regulation of nitrogen compound metabolic processGO:00511712510.112
organic cyclic compound biosynthetic processGO:19013622230.111
regulation of synaptic growth at neuromuscular junctionGO:000858210.107
growthGO:00400071740.107
Worm
regulation of signalingGO:00230512350.104
modification dependent macromolecule catabolic processGO:004363230.104
stem cell proliferationGO:007208940.104
intracellular signal transductionGO:0035556850.100
negative regulation of cellular metabolic processGO:0031324770.098
positive regulation of biological processGO:00485182530.097
Worm
regulation of nucleic acid templated transcriptionGO:19035062130.096
neuron developmentGO:00486662620.095
regulation of multicellular organism growthGO:004001440.094
Worm
organic substance biosynthetic processGO:19015762890.094
cellular aromatic compound metabolic processGO:00067252950.094
regulation of cellular biosynthetic processGO:00313262450.093
vasculature developmentGO:00019442780.092
regulation of synapse organizationGO:005080730.092
hemopoiesisGO:00300971830.091
aromatic compound biosynthetic processGO:00194382170.091
positive regulation of metabolic processGO:00098931080.088
regulation of biological qualityGO:00650082630.086
positive regulation of catabolic processGO:000989640.084
cell migrationGO:00164772370.082
negative regulation of biological processGO:00485193040.081
regulation of cellular macromolecule biosynthetic processGO:20001122220.080
heterocycle biosynthetic processGO:00181302150.079
rna biosynthetic processGO:00327741810.079
positive regulation of cellular processGO:00485222010.078
digestive tract morphogenesisGO:00485462310.076
positive regulation of cellular metabolic processGO:0031325940.076
regulation of mrna processingGO:005068430.076
immune system developmentGO:00025201910.075
sensory organ developmentGO:00074233930.074
biosynthetic processGO:00090582940.073
regulation of alternative mrna splicing via spliceosomeGO:000038110.072
stem cell divisionGO:001714510.071
digestive system developmentGO:00551232890.070
cellular protein catabolic processGO:004425740.069
response to drugGO:004249330.068
pigmentationGO:0043473850.067
response to chemicalGO:00422213200.067
developmental growthGO:00485891660.067
Worm
regulation of response to stimulusGO:00485832690.066
reproductionGO:0000003400.066
Worm
small gtpase mediated signal transductionGO:000726480.066
positive regulation of erk1 and erk2 cascadeGO:007037420.065
regulation of cell cycleGO:0051726520.064
single organism metabolic processGO:00447102170.064
positive regulation of small gtpase mediated signal transductionGO:005105710.064
regulation of rna biosynthetic processGO:20011412130.064
blood vessel developmentGO:00015682460.064
single organism reproductive processGO:0044702400.063
Worm
transcription dna templatedGO:00063511810.062
regulation of mrna splicing via spliceosomeGO:004802430.061
digestive tract developmentGO:00485652650.059
positive regulation of signalingGO:0023056560.058
protein metabolic processGO:00195381830.058
regulation of protein ubiquitinationGO:003139630.058
localization of cellGO:00516742440.058
negative regulation of gene expressionGO:0010629650.058
regulation of biosynthetic processGO:00098892500.055
positive regulation of biosynthetic processGO:0009891680.055
positive regulation of response to stimulusGO:0048584800.054
locomotory behaviorGO:0007626340.054
cell motilityGO:00488702440.054
nucleic acid metabolic processGO:00903042440.054
transcription from rna polymerase ii promoterGO:0006366800.054
positive regulation of nucleic acid templated transcriptionGO:1903508570.053
positive regulation of signal transductionGO:0009967560.053
positive regulation of cell cycleGO:004578730.052
regulation of transcription from rna polymerase ii promoterGO:00063571140.052
tube morphogenesisGO:00352393490.051
cellular nitrogen compound biosynthetic processGO:00442712180.051
regulation of epithelial cell proliferationGO:005067830.050
cellular protein modification processGO:00064641000.049
cellular biosynthetic processGO:00442492860.049
meiotic chromosome segregationGO:004513230.049
neural crest cell developmentGO:0014032620.049
nucleobase containing compound biosynthetic processGO:00346542050.048
brain developmentGO:00074202930.048
positive regulation of cellular biosynthetic processGO:0031328680.048
single organism organelle organizationGO:19025891990.047
wnt signaling pathwayGO:0016055800.046
er to golgi vesicle mediated transportGO:000688810.045
positive regulation of developmental processGO:0051094500.045
Worm
positive regulation of macromolecule metabolic processGO:0010604930.045
single organism transportGO:00447652060.043
organic acid metabolic processGO:0006082310.042
positive regulation of cellular catabolic processGO:003133130.041
positive regulation of synapse assemblyGO:005196510.041
regulation of protein modification by small protein conjugation or removalGO:190332030.040
regulation of synapse assemblyGO:005196330.040
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377100.040
gastrulationGO:00073692080.040
heart morphogenesisGO:00030071560.040
developmental process involved in reproductionGO:0003006270.038
Worm
cellular amine metabolic processGO:004410620.038
nucleic acid templated transcriptionGO:00976591810.038
ras protein signal transductionGO:000726570.037
positive regulation of cell communicationGO:0010647560.037
cell proliferationGO:0008283800.037
generation of neuronsGO:00486993850.037
cytokinesisGO:000091030.037
system processGO:00030081850.036
regulation of gene expressionGO:00104682650.036
positive regulation of multicellular organismal processGO:0051240520.036
Worm
protein importGO:001703830.036
macromolecule localizationGO:0033036540.035
neuroblast proliferationGO:000740520.035
myeloid cell differentiationGO:0030099860.035
protein localization to nucleusGO:003450430.035
organonitrogen compound metabolic processGO:1901564740.034
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.034
response to woundingGO:00096111160.034
regulation of nucleobase containing compound metabolic processGO:00192192500.033
positive regulation of ras protein signal transductionGO:004657910.033
stem cell differentiationGO:00488631170.033
morphogenesis of an epitheliumGO:00020093330.033
regulation of stem cell proliferationGO:007209120.033
skeletal system morphogenesisGO:00487051020.033
positive regulation of gene expressionGO:0010628710.033
positive regulation of transcription dna templatedGO:0045893570.033
positive regulation of rna biosynthetic processGO:1902680570.033
regulation of neural precursor cell proliferationGO:200017730.032
central nervous system neuron developmentGO:0021954290.032
negative regulation of neural precursor cell proliferationGO:200017810.032
mesenchymal cell differentiationGO:0048762870.032
positive regulation of cell deathGO:0010942290.032
single organism nuclear importGO:190259330.032
embryonic skeletal system developmentGO:0048706970.031
phosphate containing compound metabolic processGO:00067961080.031
negative regulation of synapse assemblyGO:005196420.030
nuclear importGO:005117030.030
oligodendrocyte differentiationGO:0048709230.030
positive regulation of transportGO:005105020.030
rna splicingGO:0008380160.030
protein import into nucleusGO:000660630.029
regulation of transcription dna templatedGO:00063552130.029
cellular process involved in reproduction in multicellular organismGO:0022412280.029
embryonic skeletal system morphogenesisGO:0048704930.029
tissue remodelingGO:004877140.029
compound eye developmentGO:004874920.028
amine metabolic processGO:000930820.028
nuclear transportGO:005116940.028
regulation of cell proliferationGO:0042127370.028
regulation of epidermis developmentGO:004568220.028
cellular macromolecule biosynthetic processGO:00346452240.028
regulation of cell divisionGO:0051302120.027
regulation of rac protein signal transductionGO:003502010.027
regulation of protein catabolic processGO:004217610.027
regulation of cellular component organizationGO:0051128860.027
regulation of intracellular protein transportGO:003315730.027
synapse assemblyGO:000741690.027
negative regulation of macromolecule metabolic processGO:0010605760.027
carboxylic acid metabolic processGO:0019752220.027
positive regulation of macromolecule biosynthetic processGO:0010557590.026
regulation of apoptotic processGO:0042981980.026
transmission of nerve impulseGO:0019226190.026
response to organic substanceGO:00100331530.026
regulation of cytoplasmic transportGO:190364940.026
regulation of erk1 and erk2 cascadeGO:007037240.026
regulation of establishment of protein localizationGO:007020140.026
endocytosisGO:0006897160.026
Worm
multi organism processGO:00517041340.026
positive regulation of chromosome organizationGO:200125210.026
mitotic cell cycle processGO:1903047480.025
head developmentGO:00603223030.025
positive regulation of rna metabolic processGO:0051254590.025
mitotic nuclear divisionGO:0007067180.025
apoptotic processGO:00069151160.025
embryonic heart tube developmentGO:00350501330.025
chemosensory behaviorGO:000763510.025
regulation of tube sizeGO:003515020.025
regulation of nervous system developmentGO:0051960900.024
regulation of bindingGO:005109830.024
hepaticobiliary system developmentGO:0061008980.024
oocyte anterior posterior axis specificationGO:000731440.024
regulation of circadian rhythmGO:004275240.024
cell cycleGO:0007049930.024
organelle fissionGO:0048285230.024
regulation of cellular response to oxidative stressGO:190040720.024
regulation of rho protein signal transductionGO:003502320.023
eye developmentGO:00016542770.023
striated muscle tissue developmentGO:00147061100.023
single fertilizationGO:000733830.023
cellular component morphogenesisGO:00329893360.023
regulation of oocyte developmentGO:006028130.023
angiogenesisGO:00015251580.023
nuclear divisionGO:0000280230.023
single organism localizationGO:19025782250.023
intracellular mrna localizationGO:000829810.023
regulation of developmental growthGO:0048638380.023
Worm
proteolysis involved in cellular protein catabolic processGO:005160330.022
response to external stimulusGO:00096052640.022
neuron neuron synaptic transmissionGO:000727010.022
camera type eye developmentGO:00430102220.022
regulation of localizationGO:00328791040.022
mesenchyme developmentGO:00604851270.022
skeletal muscle organ developmentGO:0060538780.022
deathGO:00162651210.021
negative regulation of biosynthetic processGO:0009890550.021
mrna splicing via spliceosomeGO:0000398100.021
macromolecule modificationGO:00434121110.021
negative regulation of molecular functionGO:0044092230.021
pole plasm assemblyGO:000731540.021
exocrine pancreas developmentGO:0031017280.020
positive regulation of myeloid cell differentiationGO:004563920.020
negative regulation of macromolecule biosynthetic processGO:0010558480.020
cell divisionGO:0051301200.020
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.020
embryonic hemopoiesisGO:0035162530.020
regulation of nucleocytoplasmic transportGO:004682220.020
stem cell maintenanceGO:001982740.020
regulation of cell activationGO:005086510.020
regulation of endothelial cell proliferationGO:000193610.020
liver developmentGO:0001889960.020
negative regulation of kinase activityGO:003367340.019
cellular component biogenesisGO:00440851780.019
ubiquitin dependent protein catabolic processGO:000651130.019
mesenchymal cell developmentGO:0014031780.019
regulation of chromosome segregationGO:005198310.019
fertilizationGO:000956630.019
protein targeting to nucleusGO:004474430.019
vesicle localizationGO:0051648270.019
muscle tissue developmentGO:00605371100.019
regulation of reproductive processGO:200024140.019
actomyosin structure organizationGO:0031032530.019
regulation of cell differentiationGO:00455951420.019
cellular component assemblyGO:00226071700.019
actin filament based processGO:0030029640.018
regulation of intracellular signal transductionGO:1902531570.018
extrinsic apoptotic signaling pathwayGO:009719130.018
regenerationGO:0031099910.018
regulation of neurogenesisGO:0050767870.018
small molecule metabolic processGO:0044281770.018
regulation of synaptic plasticityGO:004816710.018
cellular response to external stimulusGO:007149620.018
adult behaviorGO:003053420.018
cellular ketone metabolic processGO:0042180110.018
cellular response to chemical stimulusGO:00708871570.018
transmembrane transportGO:00550851200.017
regulation of protein transportGO:005122330.017
positive regulation of cellular amine metabolic processGO:003324000.017
protein modification processGO:00362111000.017
neural crest cell differentiationGO:0014033720.017
regulation of response to oxidative stressGO:190288220.017
positive regulation of cell divisionGO:005178120.017
negative regulation of rna metabolic processGO:0051253480.017
positive regulation of apoptotic signaling pathwayGO:200123510.017
positive regulation of cellular component biogenesisGO:004408930.017
reproductive processGO:0022414400.017
Worm
cell cycle g2 m phase transitionGO:004483940.017
response to stressGO:00069502630.017
skeletal muscle tissue developmentGO:0007519670.017
multicellular organismal signalingGO:0035637220.017
neuron differentiationGO:00301823530.017
mitotic dna integrity checkpointGO:004477440.016
reproductive structure developmentGO:004860850.016
Worm
regulation of embryonic developmentGO:0045995470.016
regulation of cellular protein catabolic processGO:190336210.016
behaviorGO:0007610740.016
meiotic cell cycle processGO:190304630.016
cellular localizationGO:0051641970.016
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.016
regulation of oxidative stress induced cell deathGO:190320120.016
central nervous system neuron differentiationGO:0021953740.016
forebrain developmentGO:0030900960.016
regulation of protein targetingGO:190353320.015
multicellular organismal metabolic processGO:004423620.015
neuron projection regenerationGO:0031102160.015
positive regulation of secretionGO:005104710.015
regulation of cellular amino acid metabolic processGO:000652100.015
cell death in response to oxidative stressGO:003647320.015
regulation of cell deathGO:00109411030.015
cellular amino acid metabolic processGO:000652070.015
oxoacid metabolic processGO:0043436310.015
gliogenesisGO:0042063450.015
rna processingGO:0006396250.015
erk1 and erk2 cascadeGO:007037140.015
programmed cell deathGO:00125011190.015
neurotransmitter transportGO:000683620.015
g2 m transition of mitotic cell cycleGO:000008640.015
regionalizationGO:00030022740.015
gland developmentGO:00487321430.015
regulation of protein metabolic processGO:0051246560.015
germ cell developmentGO:0007281220.015
epithelial cell differentiationGO:00308551160.015
mechanosensory behaviorGO:000763820.014
negative regulation of rna splicingGO:003311910.014
aorta developmentGO:003590440.014
positive regulation of stem cell proliferationGO:200064810.014
regulation of cellular amine metabolic processGO:003323800.014
protein acylationGO:004354330.014
regulation of autophagyGO:001050630.014
regulation of cell communicationGO:00106462320.014
maternal determination of anterior posterior axis embryoGO:000835840.014
axon developmentGO:00615641660.014
viral processGO:001603210.014
phosphorus metabolic processGO:00067931090.014
negative regulation of epithelial cell proliferationGO:005068010.014
negative regulation of cell deathGO:0060548600.014
primary neural tube formationGO:001402010.014
regulation of ion transmembrane transporter activityGO:003241220.013
mrna processingGO:0006397140.013
regulation of bone remodelingGO:004685020.013
cellular response to starvationGO:000926710.013
ribonucleoside monophosphate catabolic processGO:000915840.013
mitotic metaphase plate congressionGO:000708010.013
positive regulation of programmed cell deathGO:0043068290.013
regulation of organ growthGO:004662030.013
regulation of peptidyl tyrosine phosphorylationGO:005073010.013
gtp metabolic processGO:004603940.013
negative regulation of signal transductionGO:0009968940.013
notch signaling pathwayGO:0007219350.013
negative regulation of nucleobase containing compound metabolic processGO:0045934590.013
regulation of notch signaling pathwayGO:0008593160.013
regulation of reactive oxygen species metabolic processGO:200037720.013
negative regulation of transcription dna templatedGO:0045892450.013
multi organism reproductive processGO:0044703360.013
muscle structure developmentGO:00610611960.013
anterior posterior pattern specificationGO:00099521520.013
tissue regenerationGO:0042246740.013
positive regulation of protein metabolic processGO:0051247230.013
regulation of rna splicingGO:004348480.013
histone deacetylationGO:001657520.013
wound healingGO:0042060900.013
negative regulation of defense responseGO:003134820.012
epithelial tube morphogenesisGO:00605621480.012
golgi vesicle transportGO:004819330.012
neuron projection developmentGO:00311751800.012
sympathetic nervous system developmentGO:004848530.012
ear developmentGO:00435831270.012
intracellular estrogen receptor signaling pathwayGO:003052030.012
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.012
regulation of i kappab kinase nf kappab signalingGO:004312240.012
regulation of macromolecule biosynthetic processGO:00105562250.012
regulation of extrinsic apoptotic signaling pathwayGO:200123630.012
regulation of neuronal synaptic plasticityGO:004816810.012
symbiosis encompassing mutualism through parasitismGO:004440340.012
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.012
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.012
phagocytosisGO:000690930.012
modification dependent protein catabolic processGO:001994130.012
cytoplasm organizationGO:000702840.012
peripheral nervous system developmentGO:0007422550.012
axonogenesisGO:00074091520.012
regulation of protein bindingGO:004339330.012
organic substance transportGO:0071702580.012
cytoskeleton organizationGO:0007010960.012
modification of morphology or physiology of other organismGO:003582140.012
signal transduction by phosphorylationGO:0023014180.012
negative regulation of leukocyte differentiationGO:190210610.012
multicellular organismal macromolecule metabolic processGO:004425920.012
carbohydrate biosynthetic processGO:001605110.012
cell deathGO:00082191210.012
neurological system processGO:0050877620.011
positive regulation of multi organism processGO:004390230.011
negative regulation of nitrogen compound metabolic processGO:0051172590.011
autophagyGO:000691440.011
proteolysisGO:0006508380.011
positive regulation of neuron apoptotic processGO:004352510.011
negative regulation of protein phosphorylationGO:000193340.011
stem cell developmentGO:0048864820.011
nephron epithelium morphogenesisGO:007208810.011
chromosome organizationGO:0051276310.011
skeletal system developmentGO:00015011810.011
regulation of growthGO:0040008420.011
Worm
negative regulation of cell communicationGO:0010648960.011
muscle organ developmentGO:00075171010.011
sexual reproductionGO:0019953360.011
enzyme linked receptor protein signaling pathwayGO:00071671060.011
response to uvGO:000941130.011
regulation of cell cycle processGO:0010564200.011
regulation of mitotic cell cycle embryonicGO:000979420.011
positive regulation of neuron deathGO:190121610.011
regulation of cytokine productionGO:000181730.011
mrna metabolic processGO:0016071200.011
regulation of cell shapeGO:000836010.011
positive regulation of cellular protein metabolic processGO:0032270220.011
negative regulation of signalingGO:0023057960.011
pancreas developmentGO:0031016840.011
regulation of programmed cell deathGO:00430671010.011
positive regulation of nucleobase containing compound metabolic processGO:0045935690.010
regulation of nucleoside metabolic processGO:000911820.010
chemotaxisGO:00069351040.010
actin cytoskeleton organizationGO:0030036630.010
posttranscriptional gene silencing by rnaGO:003519430.010
negative regulation of multicellular organismal processGO:0051241690.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.010
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.010
neurotransmitter secretionGO:000726920.010
response to abiotic stimulusGO:00096281220.010
embryonic organ morphogenesisGO:00485622740.010
positive regulation of cell differentiationGO:0045597300.010
catabolic processGO:0009056320.010
phosphatidylinositol mediated signalingGO:004801520.010
embryonic organ developmentGO:00485683810.010
cell projection morphogenesisGO:00488582440.010

leo1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.033
nervous system diseaseDOID:86300.027
motor neuron diseaseDOID:23100.027
neurodegenerative diseaseDOID:128900.027
amyotrophic lateral sclerosisDOID:33200.027
central nervous system diseaseDOID:33100.027
muscle tissue diseaseDOID:6600.012
myopathyDOID:42300.012
muscular diseaseDOID:008000000.012
musculoskeletal system diseaseDOID:1700.012
disease of cellular proliferationDOID:1456600.012
cancerDOID:16200.012
organ system cancerDOID:005068600.011