IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

crybb1

crystallin, beta B1

(Aliases: zgc:92706)

Entrez: 114418
Ensembl: ENSDARG00000068507
ZFIN: ZDB-GENE-010813-1
UniProtKB: Q6DGZ8

Process Predictions
Disease Predictions

crybb1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
sensory organ development	GO:0007423	393	0.851
camera type eye development	GO:0043010	222	0.588
sensory organ morphogenesis	GO:0090596	200	0.307
positive regulation of biological process	GO:0048518	253	0.282
regeneration	GO:0031099	91	0.241
eye development	GO:0001654	277	0.220
neuron projection morphogenesis	GO:0048812	161	0.197
embryonic camera type eye development	GO:0031076	29	0.185
camera type eye morphogenesis	GO:0048593	108	0.180
lens morphogenesis in camera type eye	GO:0002089	7	0.165
cell morphogenesis	GO:0000902	289	0.147
negative regulation of cysteine type endopeptidase activity	GO:2000117	8	0.145
tissue regeneration	GO:0042246	74	0.143
larval development	GO:0002164	2	0.141
response to radiation	GO:0009314	51	0.137
wound healing	GO:0042060	90	0.129
regulation of primary metabolic process	GO:0080090	311	0.125
cell morphogenesis involved in differentiation	GO:0000904	195	0.124
embryonic organ morphogenesis	GO:0048562	274	0.118
protein metabolic process	GO:0019538	183	0.113
cellular macromolecule metabolic process	GO:0044260	391	0.105
actin cytoskeleton organization	GO:0030036	63	0.098
muscle tissue development	GO:0060537	110	0.096
stem cell division	GO:0017145	1	0.092
cellular response to chemical stimulus	GO:0070887	157	0.091
cellular component morphogenesis	GO:0032989	336	0.088
eye morphogenesis	GO:0048592	144	0.088
single organism localization	GO:1902578	225	0.086
regulation of cellular metabolic process	GO:0031323	320	0.081
epithelial cell differentiation	GO:0030855	116	0.080
sequestering of calcium ion	GO:0051208	3	0.079
negative regulation of biological process	GO:0048519	304	0.073
lens fiber cell development	GO:0070307	3	0.072
regulation of macromolecule metabolic process	GO:0060255	317	0.070
response to stress	GO:0006950	263	0.070
programmed cell death	GO:0012501	119	0.067
negative regulation of feeding behavior	GO:2000252	2	0.063
specification of axis polarity	GO:0065001	4	0.062
nitrogen compound metabolic process	GO:0006807	319	0.061
detection of abiotic stimulus	GO:0009582	24	0.061
single organism organelle organization	GO:1902589	199	0.058
sequestering of metal ion	GO:0051238	3	0.056
establishment of localization	GO:0051234	244	0.056
maintenance of location	GO:0051235	4	0.054
membrane repolarization	GO:0086009	2	0.054
system process	GO:0003008	185	0.054
muscle cell differentiation	GO:0042692	139	0.053
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.053
organelle organization	GO:0006996	227	0.052
gene expression	GO:0010467	252	0.052
cytokinesis	GO:0000910	3	0.051
fluid transport	GO:0042044	17	0.050
lens development in camera type eye	GO:0002088	22	0.049
embryonic organ development	GO:0048568	381	0.047
generation of neurons	GO:0048699	385	0.046
regulation of metabolic process	GO:0019222	359	0.046
response to abiotic stimulus	GO:0009628	122	0.046
cellular component assembly	GO:0022607	170	0.045
negative regulation of metabolic process	GO:0009892	86	0.044
single organism transport	GO:0044765	206	0.043
rna metabolic process	GO:0016070	219	0.043
cellular protein catabolic process	GO:0044257	4	0.042
adult behavior	GO:0030534	2	0.041
cellular nitrogen compound metabolic process	GO:0034641	290	0.039
cellular response to radiation	GO:0071478	4	0.039
glucose homeostasis	GO:0042593	1	0.039
cell surface receptor signaling pathway	GO:0007166	325	0.039
cellular component biogenesis	GO:0044085	178	0.039
skeletal muscle tissue development	GO:0007519	67	0.039
response to light stimulus	GO:0009416	46	0.039
actomyosin structure organization	GO:0031032	53	0.038
muscle structure development	GO:0061061	196	0.038
organic cyclic compound metabolic process	GO:1901360	301	0.037
negative regulation of sequestering of calcium ion	GO:0051283	4	0.037
regulation of signaling	GO:0023051	235	0.037
neuron development	GO:0048666	262	0.036
response to inorganic substance	GO:0010035	38	0.036
striated muscle cell differentiation	GO:0051146	129	0.036
transport	GO:0006810	220	0.036
ubiquitin dependent protein catabolic process	GO:0006511	3	0.035
positive regulation of catabolic process	GO:0009896	4	0.035
sensory perception of light stimulus	GO:0050953	19	0.034
positive regulation of cellular metabolic process	GO:0031325	94	0.034
organic substance biosynthetic process	GO:1901576	289	0.033
sensory perception	GO:0007600	39	0.032
death	GO:0016265	121	0.032
cellular aromatic compound metabolic process	GO:0006725	295	0.032
atp catabolic process	GO:0006200	4	0.031
detection of light stimulus	GO:0009583	12	0.031
neurological system process	GO:0050877	62	0.031
endocardium formation	GO:0060214	1	0.030
regulation of cell development	GO:0060284	100	0.030
cell projection morphogenesis	GO:0048858	244	0.030
regulation of cell communication	GO:0010646	232	0.030
cytoskeleton organization	GO:0007010	96	0.030
head development	GO:0060322	303	0.029
regulation of programmed cell death	GO:0043067	101	0.029
nucleic acid metabolic process	GO:0090304	244	0.029
extracellular matrix organization	GO:0030198	27	0.029
negative regulation of rna metabolic process	GO:0051253	48	0.029
chordate embryonic development	GO:0043009	271	0.029
positive regulation of cellular catabolic process	GO:0031331	3	0.029
response to chemical	GO:0042221	320	0.029
aging	GO:0007568	2	0.028
neuron fate specification	GO:0048665	20	0.028
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.028
cellular localization	GO:0051641	97	0.028
rna biosynthetic process	GO:0032774	181	0.026
heart morphogenesis	GO:0003007	156	0.026
regulation of metal ion transport	GO:0010959	4	0.026
negative regulation of endopeptidase activity	GO:0010951	10	0.026
growth	GO:0040007	174	0.026
cell cycle process	GO:0022402	53	0.026
homeostatic process	GO:0042592	142	0.026
carbohydrate homeostasis	GO:0033500	1	0.025
cellular cation homeostasis	GO:0030003	17	0.025
microtubule based process	GO:0007017	60	0.025
signal transduction	GO:0007165	455	0.025
positive regulation of cellular process	GO:0048522	201	0.025
glucocorticoid metabolic process	GO:0008211	2	0.025
cell part morphogenesis	GO:0032990	246	0.025
regulation of rna biosynthetic process	GO:2001141	213	0.024
regulation of cell differentiation	GO:0045595	142	0.024
developmental growth	GO:0048589	166	0.024
blood vessel morphogenesis	GO:0048514	216	0.024
ventral spinal cord interneuron fate commitment	GO:0060579	3	0.024
positive regulation of metabolic process	GO:0009893	108	0.024
regulation of nitrogen compound metabolic process	GO:0051171	251	0.023
biosynthetic process	GO:0009058	294	0.023
protein modification process	GO:0036211	100	0.023
sensory perception of sound	GO:0007605	9	0.023
cellular protein metabolic process	GO:0044267	129	0.022
cardiogenic plate morphogenesis	GO:0003142	1	0.022
regulation of cellular amine metabolic process	GO:0033238	0	0.022
cell fate specification	GO:0001708	68	0.022
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules	GO:0007157	2	0.022
chondrocyte intercalation involved in growth plate cartilage morphogenesis	GO:0003428	1	0.022
cellular response to external stimulus	GO:0071496	2	0.022
lipid metabolic process	GO:0006629	52	0.022
angiogenesis	GO:0001525	158	0.022
response to uv	GO:0009411	3	0.021
embryonic camera type eye morphogenesis	GO:0048596	19	0.021
negative regulation of cell death	GO:0060548	60	0.021
regulation of signal transduction	GO:0009966	225	0.021
nucleobase containing compound metabolic process	GO:0006139	274	0.021
central nervous system development	GO:0007417	387	0.020
regulation of multicellular organismal process	GO:0051239	277	0.020
modification dependent macromolecule catabolic process	GO:0043632	3	0.020
modification dependent protein catabolic process	GO:0019941	3	0.020
cellular response to light stimulus	GO:0071482	4	0.020
detection of external stimulus	GO:0009581	24	0.020
otic vesicle morphogenesis	GO:0071600	34	0.020
response to wounding	GO:0009611	116	0.020
single organism metabolic process	GO:0044710	217	0.020
negative regulation of gene expression	GO:0010629	65	0.019
cation transport	GO:0006812	81	0.019
neuron differentiation	GO:0030182	353	0.019
macromolecule biosynthetic process	GO:0009059	227	0.019
amine metabolic process	GO:0009308	2	0.019
lens fiber cell differentiation	GO:0070306	5	0.019
regulation of neurogenesis	GO:0050767	87	0.018
nucleocytoplasmic transport	GO:0006913	4	0.018
protein heterooligomerization	GO:0051291	1	0.018
heterocycle metabolic process	GO:0046483	290	0.018
specification of symmetry	GO:0009799	204	0.018
regulation of protein metabolic process	GO:0051246	56	0.018
wnt signaling pathway	GO:0016055	80	0.018
regulation of cell death	GO:0010941	103	0.018
epithelial cell development	GO:0002064	42	0.018
embryonic heart tube morphogenesis	GO:0003143	108	0.018
detection of stimulus	GO:0051606	29	0.017
neuroblast differentiation	GO:0014016	1	0.017
specification of organ identity	GO:0010092	2	0.017
heart development	GO:0007507	313	0.017
cation homeostasis	GO:0055080	33	0.017
neuroblast fate commitment	GO:0014017	1	0.017
lens fiber cell morphogenesis	GO:0070309	3	0.017
inner ear morphogenesis	GO:0042472	63	0.017
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.017
cellular response to organic substance	GO:0071310	105	0.017
skeletal system development	GO:0001501	181	0.017
response to external stimulus	GO:0009605	264	0.017
myotube cell development	GO:0014904	35	0.016
melanin biosynthetic process	GO:0042438	1	0.016
otic vesicle formation	GO:0030916	27	0.016
cellular component assembly involved in morphogenesis	GO:0010927	107	0.016
ear morphogenesis	GO:0042471	64	0.016
regulation of nucleic acid templated transcription	GO:1903506	213	0.016
ion homeostasis	GO:0050801	41	0.016
positive regulation of cell activation	GO:0050867	1	0.016
retina development in camera type eye	GO:0060041	146	0.016
positive regulation of cellular component biogenesis	GO:0044089	3	0.016
melanin metabolic process	GO:0006582	2	0.016
endocardial cushion formation	GO:0003272	2	0.016
mitotic cytokinesis	GO:0000281	3	0.016
negative regulation of apoptotic process	GO:0043066	55	0.015
lipid catabolic process	GO:0016042	4	0.015
apoptotic process	GO:0006915	116	0.015
striated muscle tissue development	GO:0014706	110	0.015
action potential	GO:0001508	19	0.015
regulation of multicellular organismal development	GO:2000026	223	0.015
single organism cellular localization	GO:1902580	46	0.015
neural tube patterning	GO:0021532	33	0.015
response to organic substance	GO:0010033	153	0.015
auditory receptor cell fate determination	GO:0042668	2	0.015
determination of bilateral symmetry	GO:0009855	204	0.015
apoptotic process involved in morphogenesis	GO:0060561	2	0.015
nuclear import	GO:0051170	3	0.015
cellular component movement	GO:0006928	335	0.015
cellular response to abiotic stimulus	GO:0071214	4	0.015
regulation of muscle hypertrophy	GO:0014743	2	0.014
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.014
meiotic nuclear division	GO:0007126	4	0.014
negative regulation of macromolecule metabolic process	GO:0010605	76	0.014
regulation of sequestering of calcium ion	GO:0051282	4	0.014
extracellular structure organization	GO:0043062	27	0.014
regulation of cell activation	GO:0050865	1	0.014
negative regulation of signaling	GO:0023057	96	0.014
regionalization	GO:0003002	274	0.014
skeletal system morphogenesis	GO:0048705	102	0.014
fin regeneration	GO:0031101	51	0.014
organelle assembly	GO:0070925	110	0.014
striated muscle cell development	GO:0055002	108	0.014
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.014
response to endogenous stimulus	GO:0009719	83	0.014
appendage development	GO:0048736	80	0.014
regulation of cellular protein metabolic process	GO:0032268	52	0.013
cellular biosynthetic process	GO:0044249	286	0.013
protein complex biogenesis	GO:0070271	30	0.013
axonogenesis	GO:0007409	152	0.013
positive regulation of macromolecule metabolic process	GO:0010604	93	0.013
establishment of cell polarity	GO:0030010	18	0.013
macromolecular complex assembly	GO:0065003	35	0.013
brain development	GO:0007420	293	0.013
behavior	GO:0007610	74	0.013
phototransduction visible light	GO:0007603	2	0.013
cellular protein modification process	GO:0006464	100	0.013
regulation of cell cycle	GO:0051726	52	0.013
metal ion homeostasis	GO:0055065	26	0.013
phagocytosis	GO:0006909	3	0.013
anterior posterior pattern specification	GO:0009952	152	0.013
stem cell proliferation	GO:0072089	4	0.013
organic cyclic compound biosynthetic process	GO:1901362	223	0.013
sex determination	GO:0007530	1	0.013
neuron projection development	GO:0031175	180	0.013
regulation of response to stimulus	GO:0048583	269	0.013
regulation of insulin like growth factor receptor signaling pathway	GO:0043567	1	0.012
embryonic heart tube development	GO:0035050	133	0.012
protein complex subunit organization	GO:0071822	46	0.012
regulation of transcription dna templated	GO:0006355	213	0.012
cellular response to endogenous stimulus	GO:0071495	68	0.012
cardiocyte differentiation	GO:0035051	44	0.012
somitogenesis	GO:0001756	87	0.012
myotube differentiation	GO:0014902	45	0.012
regulation of multicellular organism growth	GO:0040014	4	0.012
ear development	GO:0043583	127	0.012
divalent inorganic cation homeostasis	GO:0072507	22	0.012
nucleic acid templated transcription	GO:0097659	181	0.012
positive regulation of lipid metabolic process	GO:0045834	1	0.012
positive regulation of blood circulation	GO:1903524	2	0.012
cellular metal ion homeostasis	GO:0006875	16	0.012
negative regulation of programmed cell death	GO:0043069	58	0.012
protein homooligomerization	GO:0051260	3	0.012
establishment or maintenance of cell polarity	GO:0007163	29	0.012
regulation of gene expression	GO:0010468	265	0.011
protein import into nucleus	GO:0006606	3	0.011
stem cell fate determination	GO:0048867	1	0.011
vasculature development	GO:0001944	278	0.011
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.011
transmembrane transport	GO:0055085	120	0.011
apoptotic process involved in development	GO:1902742	2	0.011
skin development	GO:0043588	54	0.011
mitotic cell cycle	GO:0000278	64	0.011
regulation of protein ubiquitination	GO:0031396	3	0.011
embryo development ending in birth or egg hatching	GO:0009792	271	0.011
establishment of protein localization to organelle	GO:0072594	4	0.011
nucleoside monophosphate catabolic process	GO:0009125	4	0.011
photoperiodism	GO:0009648	11	0.011
chemical homeostasis	GO:0048878	49	0.011
regulation of biosynthetic process	GO:0009889	250	0.011
cellular amine metabolic process	GO:0044106	2	0.011
negative regulation of transcription dna templated	GO:0045892	45	0.011
estrogen metabolic process	GO:0008210	2	0.010
negative regulation of cellular metabolic process	GO:0031324	77	0.010
protein targeting to nucleus	GO:0044744	3	0.010
response to steroid hormone	GO:0048545	35	0.010
proteasomal protein catabolic process	GO:0010498	2	0.010
macromolecule modification	GO:0043412	111	0.010
meiotic cell cycle process	GO:1903046	3	0.010
multicellular organism growth	GO:0035264	4	0.010
positive regulation of epithelial cell differentiation	GO:0030858	2	0.010

crybb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.041
nervous system disease	DOID:863	0.041
disease of metabolism	DOID:0014667	0.022
eye and adnexa disease	DOID:1492	0.013
eye disease	DOID:5614	0.013
sensory system disease	DOID:0050155	0.013
retinal disease	DOID:5679	0.013

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