IMP: Integrative Multi-species Prediction

Danio rerio

106 known processes

pkd2

polycystic kidney disease 2

Entrez: 432387
ZFIN: ZDB-GENE-040827-4
Ensembl: ENSDARG00000014098
UniProtKB: Q6IVV8

Process Predictions
Disease Predictions

pkd2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
heart jogging	GO:0003146	40	0.999
determination of bilateral symmetry	GO:0009855	204	0.994
regulation of biological quality	GO:0065008	263	0.993	Human Mouse
embryonic organ development	GO:0048568	381	0.993
cilium organization	GO:0044782	71	0.989
regulation of signaling	GO:0023051	235	0.988	Human
cilium morphogenesis	GO:0060271	85	0.987
specification of symmetry	GO:0009799	204	0.983
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.981	Human Mouse
regulation of developmental process	GO:0050793	247	0.980
determination of heart left right asymmetry	GO:0061371	117	0.977
cellular component morphogenesis	GO:0032989	336	0.976
regulation of metabolic process	GO:0019222	359	0.976
negative regulation of biological process	GO:0048519	304	0.969	Human Mouse
cell part morphogenesis	GO:0032990	246	0.956
regulation of response to stimulus	GO:0048583	269	0.952	Human
cellular component biogenesis	GO:0044085	178	0.947
cell projection organization	GO:0030030	284	0.943
determination of left right symmetry	GO:0007368	179	0.941
cell morphogenesis	GO:0000902	289	0.934
organelle organization	GO:0006996	227	0.934
transport	GO:0006810	220	0.933	Human Mouse Worm
regulation of multicellular organismal development	GO:2000026	223	0.923
positive regulation of biological process	GO:0048518	253	0.914	Human Mouse
heart development	GO:0007507	313	0.906
heart morphogenesis	GO:0003007	156	0.903
embryonic organ morphogenesis	GO:0048562	274	0.897
cilium assembly	GO:0042384	58	0.895
embryonic heart tube morphogenesis	GO:0003143	108	0.895
single organism localization	GO:1902578	225	0.893	Human Mouse Worm
cilium movement	GO:0003341	26	0.892
positive regulation of response to stimulus	GO:0048584	80	0.892	Human
heart looping	GO:0001947	94	0.889
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.887
morphogenesis of an epithelium	GO:0002009	333	0.883
convergent extension	GO:0060026	118	0.881
regulation of transcription dna templated	GO:0006355	213	0.880	Human
digestive system development	GO:0055123	289	0.880
locomotion	GO:0040011	313	0.879
developmental growth involved in morphogenesis	GO:0060560	86	0.870
cell projection morphogenesis	GO:0048858	244	0.859
single organism organelle organization	GO:1902589	199	0.842
signal transduction	GO:0007165	455	0.839
embryonic heart tube development	GO:0035050	133	0.838
brain development	GO:0007420	293	0.834
nucleic acid templated transcription	GO:0097659	181	0.820	Human
epithelial cilium movement involved in determination of left right asymmetry	GO:0060287	8	0.817
regulation of cell communication	GO:0010646	232	0.804	Human
regulation of signal transduction	GO:0009966	225	0.804	Human
establishment of localization	GO:0051234	244	0.801	Human Mouse Worm
immune system process	GO:0002376	241	0.801
organelle assembly	GO:0070925	110	0.801
single organism transport	GO:0044765	206	0.798	Human Mouse Worm
macromolecule localization	GO:0033036	54	0.788	Human
cell surface receptor signaling pathway involved in heart development	GO:0061311	20	0.785
cell motility	GO:0048870	244	0.776
reproduction	GO:0000003	40	0.769	Worm
nucleobase containing compound biosynthetic process	GO:0034654	205	0.751	Human
negative regulation of cellular process	GO:0048523	283	0.738	Human Mouse
gliogenesis	GO:0042063	45	0.735
protein metabolic process	GO:0019538	183	0.734	Human
cell death	GO:0008219	121	0.726
single organism reproductive process	GO:0044702	40	0.725	Mouse
regulation of bmp signaling pathway involved in heart jogging	GO:2000223	12	0.715
heterocycle metabolic process	GO:0046483	290	0.713	Human Mouse
positive regulation of cell communication	GO:0010647	56	0.713	Human
tube morphogenesis	GO:0035239	349	0.704
nucleobase containing compound metabolic process	GO:0006139	274	0.703	Human Mouse
embryonic foregut morphogenesis	GO:0048617	1	0.694
cellular component movement	GO:0006928	335	0.665
protein localization	GO:0008104	40	0.649	Human
establishment of localization in cell	GO:0051649	77	0.644	Human Mouse
regulation of cellular component organization	GO:0051128	86	0.642
homeostatic process	GO:0042592	142	0.640	Human Mouse
cellular component assembly	GO:0022607	170	0.628
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.623	Human
regulation of rna biosynthetic process	GO:2001141	213	0.601	Human
cellular nitrogen compound metabolic process	GO:0034641	290	0.599	Human Mouse
epithelial tube morphogenesis	GO:0060562	148	0.583
cell growth	GO:0016049	57	0.580
immune system development	GO:0002520	191	0.558
gastrulation	GO:0007369	208	0.543
digestive tract development	GO:0048565	265	0.532
larval development	GO:0002164	2	0.530
heterocycle biosynthetic process	GO:0018130	215	0.530	Human
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.522	Human Mouse
growth	GO:0040007	174	0.521
multicellular organism reproduction	GO:0032504	35	0.520	Worm
ion transport	GO:0006811	114	0.510	Human Mouse Worm
neural tube development	GO:0021915	62	0.509	Human
neuron differentiation	GO:0030182	353	0.503
organic substance transport	GO:0071702	58	0.494	Human
negative regulation of metabolic process	GO:0009892	86	0.474
organic cyclic compound metabolic process	GO:1901360	301	0.473	Human Mouse
positive regulation of metabolic process	GO:0009893	108	0.472	Human Mouse
multi organism process	GO:0051704	134	0.456	Worm
regulation of nervous system development	GO:0051960	90	0.446
connective tissue development	GO:0061448	99	0.416
regulation of locomotion	GO:0040012	55	0.407
positive regulation of cellular process	GO:0048522	201	0.405	Human Mouse
cell migration	GO:0016477	237	0.400
cellular macromolecule metabolic process	GO:0044260	391	0.395	Human
negative regulation of gene expression	GO:0010629	65	0.382
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.363
regulation of anatomical structure morphogenesis	GO:0022603	130	0.354
pronephros development	GO:0048793	69	0.353
negative regulation of developmental process	GO:0051093	65	0.349
sensory organ development	GO:0007423	393	0.337
regulation of embryonic development	GO:0045995	47	0.337
cellular macromolecule biosynthetic process	GO:0034645	224	0.334	Human
primary neural tube formation	GO:0014020	1	0.332
transcription from rna polymerase ii promoter	GO:0006366	80	0.322	Human
cellular component assembly involved in morphogenesis	GO:0010927	107	0.320
mesenchyme development	GO:0060485	127	0.320	Human
ameboidal type cell migration	GO:0001667	143	0.316
macromolecular complex subunit organization	GO:0043933	74	0.316
invagination involved in gastrulation with mouth forming second	GO:0055109	1	0.314
rna metabolic process	GO:0016070	219	0.312	Human
regulation of rna metabolic process	GO:0051252	224	0.311	Human
cell proliferation involved in heart morphogenesis	GO:0061323	2	0.311
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.309
pericardium development	GO:0060039	1	0.307
regulation of protein transport	GO:0051223	3	0.307	Human
regulation of primary metabolic process	GO:0080090	311	0.304	Human Mouse
neuron development	GO:0048666	262	0.297
fin morphogenesis	GO:0033334	53	0.295
negative regulation of apoptotic process	GO:0043066	55	0.294
bmp signaling pathway involved in determination of left right symmetry	GO:0003154	14	0.293
hemopoiesis	GO:0030097	183	0.288
single organism cellular localization	GO:1902580	46	0.287	Human
heart field specification	GO:0003128	1	0.286
cell migration involved in heart development	GO:0060973	22	0.284
regulation of multicellular organismal process	GO:0051239	277	0.282
central nervous system development	GO:0007417	387	0.281	Human
positive regulation of signaling	GO:0023056	56	0.279	Human
kidney development	GO:0001822	92	0.278
anterior posterior pattern specification	GO:0009952	152	0.276
epithelial cell morphogenesis	GO:0003382	2	0.274
transcription dna templated	GO:0006351	181	0.273	Human
regulation of cell proliferation involved in heart morphogenesis	GO:2000136	2	0.263
hematopoietic or lymphoid organ development	GO:0048534	191	0.261
collagen metabolic process	GO:0032963	2	0.259
death	GO:0016265	121	0.256
cation transport	GO:0006812	81	0.254	Human Mouse Worm
aromatic compound biosynthetic process	GO:0019438	217	0.253	Human
stem cell maintenance	GO:0019827	4	0.252
microtubule based movement	GO:0007018	33	0.252
cilium movement involved in cell motility	GO:0060294	3	0.250
regulation of hematopoietic progenitor cell differentiation	GO:1901532	1	0.250
system process	GO:0003008	185	0.245
atrial ventricular junction remodeling	GO:0003294	2	0.245
localization of cell	GO:0051674	244	0.243
regulation of cell cycle	GO:0051726	52	0.240	Human Mouse
wnt signaling pathway	GO:0016055	80	0.238
inner ear development	GO:0048839	126	0.237
developmental growth	GO:0048589	166	0.237
tube closure	GO:0060606	1	0.236
cation homeostasis	GO:0055080	33	0.236	Human Mouse
heart formation	GO:0060914	13	0.231
regulation of gene expression	GO:0010468	265	0.230	Human Mouse
actin filament based process	GO:0030029	64	0.227
reproductive process	GO:0022414	40	0.218	Mouse Worm
regulation of macromolecule metabolic process	GO:0060255	317	0.218
positive regulation of catabolic process	GO:0009896	4	0.216
intermediate mesoderm development	GO:0048389	2	0.216
gene expression	GO:0010467	252	0.214	Human Mouse
aging	GO:0007568	2	0.212
ear development	GO:0043583	127	0.212
axoneme assembly	GO:0035082	9	0.212
protein complex subunit organization	GO:0071822	46	0.211
heart valve morphogenesis	GO:0003179	8	0.207
nephron epithelium morphogenesis	GO:0072088	1	0.206	Human
epiboly involved in gastrulation with mouth forming second	GO:0055113	35	0.205
morphogenesis of an epithelial fold	GO:0060571	1	0.203
cell surface receptor signaling pathway	GO:0007166	325	0.203
outflow tract morphogenesis	GO:0003151	1	0.203
positive regulation of transport	GO:0051050	2	0.202	Human
response to chemical	GO:0042221	320	0.202	Human
cellular localization	GO:0051641	97	0.200	Human Mouse
pericardium morphogenesis	GO:0003344	1	0.197
regulation of wnt signaling pathway involved in heart development	GO:0003307	2	0.197
positive regulation of signal transduction	GO:0009967	56	0.196	Human
regulation of programmed cell death	GO:0043067	101	0.192
regulation of heart morphogenesis	GO:2000826	17	0.187
regulation of cellular protein metabolic process	GO:0032268	52	0.187	Human
neuron projection morphogenesis	GO:0048812	161	0.185
foregut morphogenesis	GO:0007440	4	0.183
embryonic skeletal joint development	GO:0072498	3	0.182
mesodermal to mesenchymal transition involved in gastrulation	GO:0060809	1	0.182
steroid hormone mediated signaling pathway	GO:0043401	9	0.180
response to biotic stimulus	GO:0009607	97	0.179
renal system development	GO:0072001	94	0.179
chordate embryonic development	GO:0043009	271	0.177	Human Mouse
biosynthetic process	GO:0009058	294	0.173
heart rudiment morphogenesis	GO:0003314	6	0.172
metal ion transport	GO:0030001	58	0.169	Human Mouse Worm
cilium or flagellum dependent cell motility	GO:0001539	4	0.169
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.168
epithelial cilium movement	GO:0003351	15	0.168
endocardial cell differentiation	GO:0060956	5	0.166
mitotic nuclear division	GO:0007067	18	0.165
cell cell adhesion involved in mesendodermal cell migration	GO:0003370	1	0.163
response to stress	GO:0006950	263	0.162	Human Mouse
cell morphogenesis involved in differentiation	GO:0000904	195	0.160
epithelial tube formation	GO:0072175	19	0.160
regionalization	GO:0003002	274	0.158
rna biosynthetic process	GO:0032774	181	0.158	Human
somite development	GO:0061053	96	0.157
regulation of localization	GO:0032879	104	0.157	Human Mouse
cardiac endothelial cell differentiation	GO:0003348	5	0.157
cellular aromatic compound metabolic process	GO:0006725	295	0.156	Human Mouse
response to external stimulus	GO:0009605	264	0.156	Mouse
establishment of endothelial barrier	GO:0061028	3	0.155
regulation of cell development	GO:0060284	100	0.154
intracellular signal transduction	GO:0035556	85	0.153
sexual reproduction	GO:0019953	36	0.152	Worm
negative regulation of macromolecule metabolic process	GO:0010605	76	0.150
positive regulation of cell adhesion	GO:0045785	1	0.150
negative regulation of cell death	GO:0060548	60	0.146
negative regulation of cell differentiation	GO:0045596	46	0.145
digestive tract morphogenesis	GO:0048546	231	0.145
regulation of axon extension	GO:0030516	24	0.144
female sex differentiation	GO:0046660	4	0.143
determination of liver left right asymmetry	GO:0071910	11	0.141	Human
generation of neurons	GO:0048699	385	0.140
regulation of cell death	GO:0010941	103	0.136
mitotic cell cycle	GO:0000278	64	0.135	Human
positive regulation of protein metabolic process	GO:0051247	23	0.134	Human
regulation of cellular metabolic process	GO:0031323	320	0.132	Human Mouse
urogenital system development	GO:0001655	97	0.132
programmed cell death	GO:0012501	119	0.132
cytoskeleton organization	GO:0007010	96	0.131
epithelial cell differentiation	GO:0030855	116	0.130
mitotic cell cycle process	GO:1903047	48	0.130	Human
gall bladder development	GO:0061010	1	0.126
positive regulation of catalytic activity	GO:0043085	25	0.125	Human
positive regulation of molecular function	GO:0044093	33	0.122	Human
nephron tubule morphogenesis	GO:0072078	1	0.121	Human
regulation of cell projection organization	GO:0031344	44	0.119
regulation of establishment of planar polarity	GO:0090175	4	0.116
muscle cell differentiation	GO:0042692	139	0.113
endoderm development	GO:0007492	49	0.112
positive regulation of stress activated protein kinase signaling cascade	GO:0070304	3	0.112
stem cell differentiation	GO:0048863	117	0.111
macromolecular complex assembly	GO:0065003	35	0.109
tube formation	GO:0035148	25	0.108
positive regulation of neural precursor cell proliferation	GO:2000179	1	0.107
head development	GO:0060322	303	0.107
cell projection assembly	GO:0030031	64	0.107
regulation of molecular function	GO:0065009	70	0.106	Human Mouse
organic cyclic compound biosynthetic process	GO:1901362	223	0.105	Human
regulation of organ morphogenesis	GO:2000027	35	0.104
mesendoderm development	GO:0048382	10	0.103
cell cycle process	GO:0022402	53	0.102	Human Mouse
regulation of synapse assembly	GO:0051963	3	0.102
anterior posterior axis specification	GO:0009948	20	0.101
inner ear morphogenesis	GO:0042472	63	0.100
negative regulation of programmed cell death	GO:0043069	58	0.099
protein complex assembly	GO:0006461	30	0.098
regulation of nucleic acid templated transcription	GO:1903506	213	0.098	Human
cellular protein localization	GO:0034613	20	0.097	Human
small gtpase mediated signal transduction	GO:0007264	8	0.097
intracellular transport	GO:0046907	32	0.096	Human Mouse
regulation of bone mineralization	GO:0030500	2	0.096
embryonic epithelial tube formation	GO:0001838	17	0.096
regulation of immune system process	GO:0002682	34	0.095
response to bacterium	GO:0009617	58	0.093
regulation of cell motility	GO:2000145	46	0.093
semicircular canal morphogenesis	GO:0048752	18	0.092
appendage morphogenesis	GO:0035107	56	0.091
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.091
apoptotic process	GO:0006915	116	0.091
humoral immune response mediated by circulating immunoglobulin	GO:0002455	3	0.090
glomerulus vasculature development	GO:0072012	2	0.090
retinal ganglion cell axon guidance	GO:0031290	35	0.090
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.088	Human Mouse
embryonic digestive tract morphogenesis	GO:0048557	3	0.088
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.088
nucleocytoplasmic transport	GO:0006913	4	0.087	Human
eye morphogenesis	GO:0048592	144	0.086
embryonic axis specification	GO:0000578	12	0.085
single organism membrane organization	GO:0044802	20	0.085
establishment or maintenance of monopolar cell polarity	GO:0061339	2	0.084
striated muscle tissue development	GO:0014706	110	0.084
muscle tissue development	GO:0060537	110	0.084	Human
negative regulation of wnt signaling pathway involved in heart development	GO:0003308	2	0.084
negative regulation of cellular metabolic process	GO:0031324	77	0.083
calcium ion import	GO:0070509	4	0.081	Human
positive regulation of striated muscle tissue development	GO:0045844	1	0.081
establishment of apical basal cell polarity	GO:0035089	2	0.081
negative regulation of response to stimulus	GO:0048585	104	0.081
skeletal system morphogenesis	GO:0048705	102	0.079
cellular macromolecule localization	GO:0070727	21	0.079	Human
cell migration involved in gastrulation	GO:0042074	79	0.079
negative regulation of growth	GO:0045926	10	0.079
cellular component disassembly	GO:0022411	1	0.078
regulation of growth	GO:0040008	42	0.076
regulation of muscle tissue development	GO:1901861	6	0.076
blood vessel morphogenesis	GO:0048514	216	0.076	Human
anterior head development	GO:0097065	2	0.076
positive regulation of cellular protein metabolic process	GO:0032270	22	0.076	Human
protein complex biogenesis	GO:0070271	30	0.076
homeostasis of number of cells	GO:0048872	62	0.075
regulation of skeletal muscle tissue development	GO:0048641	4	0.075
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.073	Human
embryo development ending in birth or egg hatching	GO:0009792	271	0.073	Human Mouse
unidimensional cell growth	GO:0009826	5	0.073
striated muscle cell differentiation	GO:0051146	129	0.073
phosphate containing compound metabolic process	GO:0006796	108	0.072	Human Mouse
organic substance biosynthetic process	GO:1901576	289	0.071
positive regulation of cell cycle	GO:0045787	3	0.071	Human
cellular ion homeostasis	GO:0006873	17	0.071	Human Mouse
regulation of apoptotic process	GO:0042981	98	0.071
regulation of biosynthetic process	GO:0009889	250	0.070
regulation of protein targeting	GO:1903533	2	0.070	Human
positive regulation of muscle organ development	GO:0048636	1	0.070
regulation of cell morphogenesis	GO:0022604	42	0.069
atrioventricular valve formation	GO:0003190	3	0.068
regulation of chondrocyte differentiation	GO:0032330	1	0.068
negative regulation of biosynthetic process	GO:0009890	55	0.067
nucleic acid metabolic process	GO:0090304	244	0.066	Human
multicellular organismal reproductive process	GO:0048609	35	0.066	Worm
membrane organization	GO:0061024	21	0.066
negative regulation of rna metabolic process	GO:0051253	48	0.066
catabolic process	GO:0009056	32	0.065
regulation of multicellular organism growth	GO:0040014	4	0.065
sensory organ morphogenesis	GO:0090596	200	0.065
neurological system process	GO:0050877	62	0.064
stem cell division	GO:0017145	1	0.064
regulation of cellular component movement	GO:0051270	55	0.064
epithelial to mesenchymal transition	GO:0001837	21	0.064
regulation of stem cell proliferation	GO:0072091	2	0.063
positive regulation of macromolecule metabolic process	GO:0010604	93	0.062	Human Mouse
negative regulation of muscle tissue development	GO:1901862	2	0.062
cardiocyte differentiation	GO:0035051	44	0.062
establishment or maintenance of cell polarity	GO:0007163	29	0.062
endocardium morphogenesis	GO:0003160	4	0.062
regulation of organelle organization	GO:0033043	29	0.061
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.061	Human
regulation of catalytic activity	GO:0050790	55	0.060	Human
response to abiotic stimulus	GO:0009628	122	0.060	Human Mouse
wnt signaling pathway involved in heart development	GO:0003306	5	0.059
rho protein signal transduction	GO:0007266	5	0.059
axis elongation	GO:0003401	31	0.058
negative regulation of cellular component organization	GO:0051129	16	0.058
cell fate commitment	GO:0045165	99	0.058
axial mesoderm formation	GO:0048320	4	0.057
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.057
regulation of nitrogen compound metabolic process	GO:0051171	251	0.056	Human Mouse
cartilage morphogenesis	GO:0060536	13	0.056
optic placode formation	GO:0001743	4	0.056
regulation of binding	GO:0051098	3	0.056
regulation of intracellular signal transduction	GO:1902531	57	0.056	Human
establishment of organelle localization	GO:0051656	45	0.056
positive regulation of skeletal muscle tissue development	GO:0048643	1	0.055
regulation of cell differentiation	GO:0045595	142	0.055
determination of left right asymmetry in lateral mesoderm	GO:0003140	20	0.055
cell proliferation	GO:0008283	80	0.055	Human
ear morphogenesis	GO:0042471	64	0.054
ion homeostasis	GO:0050801	41	0.053	Human Mouse
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	4	0.053
skin development	GO:0043588	54	0.053
homeostasis of number of cells within a tissue	GO:0048873	4	0.053
biological adhesion	GO:0022610	40	0.053
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.052	Human
endochondral bone morphogenesis	GO:0060350	8	0.052
regulation of protein catabolic process	GO:0042176	1	0.052
establishment of protein localization to plasma membrane	GO:0090002	1	0.051
blood vessel development	GO:0001568	246	0.051	Human Mouse
regulation of establishment of protein localization	GO:0070201	4	0.051	Human
neuron projection extension	GO:1990138	45	0.050
wnt signaling pathway involved in somitogenesis	GO:0090244	2	0.050
retinal cone cell development	GO:0046549	8	0.050
response to fluid shear stress	GO:0034405	2	0.050	Human Mouse
cardioblast migration to the midline involved in heart rudiment formation	GO:0003319	5	0.050
multicellular organism growth	GO:0035264	4	0.049
cell adhesion	GO:0007155	40	0.049
chemotaxis	GO:0006935	104	0.049
taxis	GO:0042330	109	0.048
regulation of cell migration	GO:0030334	40	0.048
semicircular canal development	GO:0060872	24	0.048
keratinocyte differentiation	GO:0030216	0	0.047
regulation of reproductive process	GO:2000241	4	0.047
gamete generation	GO:0007276	33	0.047
regulation of cell proliferation	GO:0042127	37	0.046	Human
establishment of monopolar cell polarity	GO:0061162	2	0.046
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.046
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.046	Human
behavior	GO:0007610	74	0.045	Worm
positive regulation of cellular metabolic process	GO:0031325	94	0.044	Human Mouse
cognition	GO:0050890	1	0.044
negative regulation of striated muscle tissue development	GO:0045843	2	0.044
response to other organism	GO:0051707	97	0.044
negative regulation of chemotaxis	GO:0050922	4	0.044
regulation of muscle organ development	GO:0048634	9	0.043
positive regulation of ras protein signal transduction	GO:0046579	1	0.043
mesenchymal cell development	GO:0014031	78	0.043
notochord cell differentiation	GO:0060034	18	0.041
response to external biotic stimulus	GO:0043207	97	0.041
cell cell adhesion mediated by cadherin	GO:0044331	5	0.041
axonogenesis	GO:0007409	152	0.041
neuron projection development	GO:0031175	180	0.041
hard palate development	GO:0060022	4	0.041
negative regulation of axon extension involved in axon guidance	GO:0048843	1	0.041
multi organism reproductive process	GO:0044703	36	0.041	Worm
regulation of axonogenesis	GO:0050770	32	0.040
bone development	GO:0060348	14	0.040
myeloid cell homeostasis	GO:0002262	56	0.040
negative regulation of wnt signaling pathway	GO:0030178	30	0.040
ras protein signal transduction	GO:0007265	7	0.039
organonitrogen compound metabolic process	GO:1901564	74	0.039	Mouse
muscle structure development	GO:0061061	196	0.039
astrocyte differentiation	GO:0048708	1	0.039
hepaticobiliary system development	GO:0061008	98	0.039	Human Mouse
regulation of stem cell differentiation	GO:2000736	4	0.038
proteolysis	GO:0006508	38	0.038
bmp signaling pathway	GO:0030509	52	0.038
neural crest cell migration	GO:0001755	42	0.038
immune response	GO:0006955	28	0.038
regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901213	15	0.038
calcium ion homeostasis	GO:0055074	19	0.037	Human Mouse
negative regulation of transcription dna templated	GO:0045892	45	0.037
carbohydrate derivative biosynthetic process	GO:1901137	43	0.037
regulation of behavior	GO:0050795	24	0.037
heart valve development	GO:0003170	14	0.037
regulation of nucleocytoplasmic transport	GO:0046822	2	0.036	Human
positive regulation of nervous system development	GO:0051962	25	0.036
biomineral tissue development	GO:0031214	13	0.036
meiotic cell cycle process	GO:1903046	3	0.036
regulation of tube size	GO:0035150	2	0.036
establishment of mitotic spindle localization	GO:0040001	12	0.036
positive regulation of cell development	GO:0010720	25	0.036
heart rudiment development	GO:0003313	8	0.035
establishment of cell polarity	GO:0030010	18	0.035
fin regeneration	GO:0031101	51	0.035
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.035
embryonic skeletal joint morphogenesis	GO:0060272	3	0.035
establishment of protein localization to organelle	GO:0072594	4	0.035	Human
specification of axis polarity	GO:0065001	4	0.035
stem cell development	GO:0048864	82	0.034
positive regulation of cell proliferation	GO:0008284	15	0.034
axon extension	GO:0048675	45	0.034
positive regulation of stress activated mapk cascade	GO:0032874	3	0.034
left right pattern formation	GO:0060972	19	0.033
cellular cation homeostasis	GO:0030003	17	0.033	Human Mouse
germ line stem cell maintenance	GO:0030718	2	0.033
purine nucleotide metabolic process	GO:0006163	27	0.033	Mouse
positive regulation of stem cell proliferation	GO:2000648	1	0.033
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.033
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.033
positive regulation of jun kinase activity	GO:0043507	2	0.032
regulation of mitotic cell cycle	GO:0007346	25	0.032	Human
mononuclear cell proliferation	GO:0032943	1	0.032
regulation of neuron projection development	GO:0010975	40	0.032
positive regulation of gastrulation	GO:2000543	2	0.032
regulation of cell cell adhesion	GO:0022407	13	0.032
microtubule bundle formation	GO:0001578	9	0.032
stem cell proliferation	GO:0072089	4	0.032
actin cytoskeleton organization	GO:0030036	63	0.032
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.031
atrioventricular valve development	GO:0003171	11	0.031
negative regulation of cell proliferation	GO:0008285	8	0.031
regulation of proteolysis	GO:0030162	24	0.031
inner ear receptor stereocilium organization	GO:0060122	8	0.031
microtubule based process	GO:0007017	60	0.031
regulation of biomineral tissue development	GO:0070167	2	0.031
b cell mediated immunity	GO:0019724	3	0.031
response to organic cyclic compound	GO:0014070	51	0.031
response to alkaloid	GO:0043279	2	0.030
regulation of dendrite development	GO:0050773	3	0.030
neural tube formation	GO:0001841	16	0.030
cardiac cell fate commitment	GO:0060911	1	0.030
fin development	GO:0033333	77	0.030
cellular biosynthetic process	GO:0044249	286	0.030	Human Mouse
regulation of wnt signaling pathway	GO:0030111	53	0.030
cellular carbohydrate metabolic process	GO:0044262	4	0.030
wnt signaling pathway planar cell polarity pathway	GO:0060071	4	0.029
immunoglobulin mediated immune response	GO:0016064	3	0.029
modification dependent macromolecule catabolic process	GO:0043632	3	0.029
embryonic pattern specification	GO:0009880	44	0.029
hatching	GO:0035188	4	0.029
somatic stem cell maintenance	GO:0035019	1	0.029
cell substrate adhesion	GO:0031589	4	0.029
organelle localization	GO:0051640	49	0.028
negative regulation of rna biosynthetic process	GO:1902679	45	0.028
regulation of microtubule based movement	GO:0060632	3	0.028
nephron tubule epithelial cell differentiation	GO:0072160	1	0.028
defense response to fungus	GO:0050832	2	0.028
intestinal epithelial cell differentiation	GO:0060575	3	0.028
hormone biosynthetic process	GO:0042446	3	0.028
optic placode formation involved in camera type eye formation	GO:0046619	3	0.027
organelle fission	GO:0048285	23	0.027

pkd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.066
organ system cancer	DOID:0050686	0.066
disease of cellular proliferation	DOID:14566	0.066
disease of anatomical entity	DOID:7	0.059

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