IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

sf3a2

splicing factor 3a, subunit 2

(Aliases: zgc:56097,zgc:77448,MGC56097)

ZFIN: ZDB-GENE-040426-897
Entrez: 394018
Ensembl: ENSDARG00000021107
UniProtKB: Q7ZVD4

Process Predictions
Disease Predictions

sf3a2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
larval development	GO:0002164	2	0.826	Worm
regulation of mrna processing	GO:0050684	3	0.531
rna metabolic process	GO:0016070	219	0.383	Human
locomotion	GO:0040011	313	0.380	Worm
nucleobase containing compound metabolic process	GO:0006139	274	0.345	Human
embryo development ending in birth or egg hatching	GO:0009792	271	0.309	Worm
cellular macromolecule metabolic process	GO:0044260	391	0.305	Human
organic cyclic compound metabolic process	GO:1901360	301	0.270	Human
transcription dna templated	GO:0006351	181	0.257
cellular nitrogen compound metabolic process	GO:0034641	290	0.247	Human
regulation of mrna splicing via spliceosome	GO:0048024	3	0.204
response to stress	GO:0006950	263	0.199
cell cycle	GO:0007049	93	0.193	Fly
muscle structure development	GO:0061061	196	0.187	Worm
regulation of alternative mrna splicing via spliceosome	GO:0000381	1	0.165
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.160
cell projection organization	GO:0030030	284	0.151
negative regulation of biological process	GO:0048519	304	0.146
generation of neurons	GO:0048699	385	0.142
macromolecule biosynthetic process	GO:0009059	227	0.141
nucleic acid templated transcription	GO:0097659	181	0.140
gene expression	GO:0010467	252	0.134	Human
regulation of gene expression	GO:0010468	265	0.130
rna biosynthetic process	GO:0032774	181	0.129
alternative mrna splicing via spliceosome	GO:0000380	1	0.125
regulation of rna metabolic process	GO:0051252	224	0.123
neuron differentiation	GO:0030182	353	0.121
meiotic nuclear division	GO:0007126	4	0.117
rna localization	GO:0006403	4	0.110
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.108
regulation of metabolic process	GO:0019222	359	0.107	Fly
mitotic cell cycle	GO:0000278	64	0.106	Fly
neuron development	GO:0048666	262	0.102
intracellular mrna localization	GO:0008298	1	0.092
organelle organization	GO:0006996	227	0.091	Worm Fly
nuclear transport	GO:0051169	4	0.091
gamete generation	GO:0007276	33	0.090	Worm
positive regulation of rna splicing	GO:0033120	1	0.089
regulation of biosynthetic process	GO:0009889	250	0.088
regulation of mrna metabolic process	GO:1903311	6	0.087
heterocycle metabolic process	GO:0046483	290	0.086	Human
single organism organelle organization	GO:1902589	199	0.086	Worm Fly
regulation of nucleic acid templated transcription	GO:1903506	213	0.085
regulation of rna biosynthetic process	GO:2001141	213	0.085
nuclear transcribed mrna catabolic process nonsense mediated decay	GO:0000184	4	0.084
muscle organ development	GO:0007517	101	0.083
biosynthetic process	GO:0009058	294	0.081
rna splicing	GO:0008380	16	0.078
cellular aromatic compound metabolic process	GO:0006725	295	0.077	Human
organism emergence from protective structure	GO:0071684	4	0.077
regulation of cellular metabolic process	GO:0031323	320	0.074	Fly
cell cycle process	GO:0022402	53	0.072	Fly
nitrogen compound metabolic process	GO:0006807	319	0.070	Human
aromatic compound biosynthetic process	GO:0019438	217	0.070
mrna splicing via spliceosome	GO:0000398	10	0.069
apoptotic process	GO:0006915	116	0.067
negative regulation of rna splicing	GO:0033119	1	0.066
regulation of cellular biosynthetic process	GO:0031326	245	0.062
regulation of nitrogen compound metabolic process	GO:0051171	251	0.060
cellular component morphogenesis	GO:0032989	336	0.058	Worm
organic substance biosynthetic process	GO:1901576	289	0.058
cellular macromolecule biosynthetic process	GO:0034645	224	0.057
response to external stimulus	GO:0009605	264	0.057
regulation of macromolecule metabolic process	GO:0060255	317	0.056
regulation of primary metabolic process	GO:0080090	311	0.055
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.054
regulation of meiotic cell cycle	GO:0051445	1	0.053
dna templated transcription elongation	GO:0006354	3	0.053
organic cyclic compound biosynthetic process	GO:1901362	223	0.053
lateral inhibition	GO:0046331	1	0.051
oocyte anterior posterior axis specification	GO:0007314	4	0.051
rna splicing via transesterification reactions	GO:0000375	10	0.050
maturation of ssu rrna	GO:0030490	1	0.050
regulation of transcription dna templated	GO:0006355	213	0.049
regulation of macromolecule biosynthetic process	GO:0010556	225	0.048
positive regulation of small gtpase mediated signal transduction	GO:0051057	1	0.045	Fly
nucleobase containing compound biosynthetic process	GO:0034654	205	0.045
regulation of protein ubiquitination	GO:0031396	3	0.043
cell part morphogenesis	GO:0032990	246	0.042
neuron projection development	GO:0031175	180	0.042
negative regulation of cellular process	GO:0048523	283	0.041
viral process	GO:0016032	1	0.041
cellular response to external stimulus	GO:0071496	2	0.039
multi organism process	GO:0051704	134	0.039	Worm
cellular response to extracellular stimulus	GO:0031668	2	0.039
negative regulation of developmental process	GO:0051093	65	0.038
cellular biosynthetic process	GO:0044249	286	0.037
negative regulation of mrna processing	GO:0050686	1	0.036
positive regulation of mrna splicing via spliceosome	GO:0048026	1	0.036
proteasomal protein catabolic process	GO:0010498	2	0.036
neuron projection morphogenesis	GO:0048812	161	0.036
regulation of endopeptidase activity	GO:0052548	23	0.036
cellular component movement	GO:0006928	335	0.035
regulation of multicellular organismal development	GO:2000026	223	0.034
protein complex subunit organization	GO:0071822	46	0.034	Worm Fly
cellular protein catabolic process	GO:0044257	4	0.034
regulation of transcription from rna polymerase iii promoter	GO:0006359	1	0.034
regulation of signal transduction	GO:0009966	225	0.033	Fly
nucleic acid metabolic process	GO:0090304	244	0.033	Human
modification dependent macromolecule catabolic process	GO:0043632	3	0.032
cellular component biogenesis	GO:0044085	178	0.032	Worm
actin filament based process	GO:0030029	64	0.031	Worm
regulation of rna splicing	GO:0043484	8	0.031
cellular component assembly	GO:0022607	170	0.031	Worm
aging	GO:0007568	2	0.031
spliceosomal snrnp assembly	GO:0000387	2	0.030
chemotaxis	GO:0006935	104	0.030
positive regulation of translation	GO:0045727	1	0.030
cellular component disassembly	GO:0022411	1	0.030
regulation of erk1 and erk2 cascade	GO:0070372	4	0.030	Fly
single fertilization	GO:0007338	3	0.029
macromolecular complex assembly	GO:0065003	35	0.029	Worm
nuclear export	GO:0051168	1	0.029
cell death	GO:0008219	121	0.029
meiotic cell cycle process	GO:1903046	3	0.029
symbiosis encompassing mutualism through parasitism	GO:0044403	4	0.029
regulation of protein catabolic process	GO:0042176	1	0.028
skeletal system morphogenesis	GO:0048705	102	0.028
positive regulation of metabolic process	GO:0009893	108	0.028	Fly
fertilization	GO:0009566	3	0.028
protein complex disassembly	GO:0043241	1	0.027
cell projection morphogenesis	GO:0048858	244	0.027
heterocycle biosynthetic process	GO:0018130	215	0.027
mrna processing	GO:0006397	14	0.027	Human
programmed cell death	GO:0012501	119	0.027
cellular localization	GO:0051641	97	0.026
positive regulation of cell cycle	GO:0045787	3	0.026
single organism metabolic process	GO:0044710	217	0.026	Fly
embryonic organ morphogenesis	GO:0048562	274	0.026
mrna metabolic process	GO:0016071	20	0.025	Human
translational initiation	GO:0006413	3	0.025
positive regulation of cellular process	GO:0048522	201	0.025	Fly
regulation of signaling	GO:0023051	235	0.025	Fly
cytoskeleton organization	GO:0007010	96	0.025	Worm Fly
cellular response to dna damage stimulus	GO:0006974	24	0.025
ras protein signal transduction	GO:0007265	7	0.025	Fly
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000462	1	0.025
muscle cell differentiation	GO:0042692	139	0.024	Worm
reproduction	GO:0000003	40	0.024	Worm
transcription from rna polymerase ii promoter	GO:0006366	80	0.024
meiotic chromosome segregation	GO:0045132	3	0.024
response to alkaloid	GO:0043279	2	0.024
negative regulation of cell differentiation	GO:0045596	46	0.024
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.024
response to carbohydrate	GO:0009743	3	0.024
cellular response to nutrient levels	GO:0031669	2	0.024
regulation of cell differentiation	GO:0045595	142	0.024
positive regulation of catabolic process	GO:0009896	4	0.023
embryonic organ development	GO:0048568	381	0.023
embryonic skeletal system development	GO:0048706	97	0.023
locomotor rhythm	GO:0045475	3	0.023
cytokinesis	GO:0000910	3	0.023
chordate embryonic development	GO:0043009	271	0.023
response to nutrient	GO:0007584	3	0.022
macromolecular complex disassembly	GO:0032984	1	0.022
positive regulation of molecular function	GO:0044093	33	0.022
cell morphogenesis	GO:0000902	289	0.022
protein complex assembly	GO:0006461	30	0.022	Worm
regulation of translational initiation	GO:0006446	1	0.022
microtubule cytoskeleton organization	GO:0000226	33	0.022	Fly
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.022
cell morphogenesis involved in differentiation	GO:0000904	195	0.022
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.022
organelle fission	GO:0048285	23	0.022
response to abiotic stimulus	GO:0009628	122	0.021
phagocytosis	GO:0006909	3	0.021
multicellular organismal reproductive process	GO:0048609	35	0.021	Worm
cellular response to stress	GO:0033554	62	0.021
germ cell development	GO:0007281	22	0.021	Worm
spermatid development	GO:0007286	2	0.021
regulation of cell cycle	GO:0051726	52	0.021
nuclear division	GO:0000280	23	0.021
positive regulation of epithelial cell proliferation	GO:0050679	1	0.021
transcription from rna polymerase iii promoter	GO:0006383	1	0.020
negative regulation of rna biosynthetic process	GO:1902679	45	0.020
intracellular signal transduction	GO:0035556	85	0.020	Fly
cell cycle g1 s phase transition	GO:0044843	1	0.020
regulation of epithelial cell proliferation	GO:0050678	3	0.020
negative regulation of multicellular organismal process	GO:0051241	69	0.020
establishment of protein localization to organelle	GO:0072594	4	0.020
regulation of nucleocytoplasmic transport	GO:0046822	2	0.020
multi organism reproductive process	GO:0044703	36	0.020	Worm
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.020
cellular protein metabolic process	GO:0044267	129	0.020
cytoskeleton dependent cytokinesis	GO:0061640	3	0.020
ubiquitin dependent protein catabolic process	GO:0006511	3	0.020
regulation of cytoplasmic transport	GO:1903649	4	0.020
positive regulation of biological process	GO:0048518	253	0.019	Fly
cell proliferation	GO:0008283	80	0.019
signal transduction	GO:0007165	455	0.019	Fly
protein localization to nucleus	GO:0034504	3	0.019
embryonic skeletal system morphogenesis	GO:0048704	93	0.019
central nervous system development	GO:0007417	387	0.019
small gtpase mediated signal transduction	GO:0007264	8	0.019	Fly
nucleocytoplasmic transport	GO:0006913	4	0.019
cellular response to biotic stimulus	GO:0071216	3	0.019
death	GO:0016265	121	0.019
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.019
sexual reproduction	GO:0019953	36	0.019	Worm
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	2	0.019
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	10	0.018
positive regulation of macromolecule metabolic process	GO:0010604	93	0.018
neuron projection guidance	GO:0097485	86	0.018
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.018	Fly
response to monosaccharide	GO:0034284	3	0.018
positive regulation of cellular metabolic process	GO:0031325	94	0.018	Fly
regulation of programmed cell death	GO:0043067	101	0.018
positive regulation of mrna metabolic process	GO:1903313	2	0.018
oogenesis	GO:0048477	14	0.018
heart development	GO:0007507	313	0.018
nuclear import	GO:0051170	3	0.018
protein complex biogenesis	GO:0070271	30	0.017	Worm
single organism transport	GO:0044765	206	0.017
lipid storage	GO:0019915	1	0.017
transcription elongation from rna polymerase ii promoter	GO:0006368	3	0.017
negative regulation of rna metabolic process	GO:0051253	48	0.017
positive regulation of cellular biosynthetic process	GO:0031328	68	0.017
regulation of response to stimulus	GO:0048583	269	0.017	Fly
sensory organ morphogenesis	GO:0090596	200	0.016
maternal determination of anterior posterior axis embryo	GO:0008358	4	0.016
compound eye development	GO:0048749	2	0.016
wnt signaling pathway	GO:0016055	80	0.016
cognition	GO:0050890	1	0.016
positive regulation of ras protein signal transduction	GO:0046579	1	0.016	Fly
axonogenesis	GO:0007409	152	0.016
taxis	GO:0042330	109	0.016
hatching	GO:0035188	4	0.016
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.016
regulation of protein complex assembly	GO:0043254	3	0.016
regulation of cell death	GO:0010941	103	0.016
response to hexose	GO:0009746	3	0.016
cytoplasm organization	GO:0007028	4	0.016
establishment of rna localization	GO:0051236	3	0.015
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.015
pole plasm assembly	GO:0007315	4	0.015
protein metabolic process	GO:0019538	183	0.015
multicellular organism reproduction	GO:0032504	35	0.015	Worm
regionalization	GO:0003002	274	0.015
positive regulation of gene expression	GO:0010628	71	0.015
protein polymerization	GO:0051258	4	0.015
atp catabolic process	GO:0006200	4	0.015
pigment granule localization	GO:0051875	25	0.015
negative regulation of mrna splicing via spliceosome	GO:0048025	1	0.015
regulation of cellular component organization	GO:0051128	86	0.014
skeletal system development	GO:0001501	181	0.014
regulation of protein metabolic process	GO:0051246	56	0.014
regulation of apoptotic process	GO:0042981	98	0.014
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.014
cellular response to starvation	GO:0009267	1	0.014
segmentation	GO:0035282	97	0.014
meiotic spindle organization	GO:0000212	1	0.014
dna metabolic process	GO:0006259	27	0.014
single organism nuclear import	GO:1902593	3	0.014
stem cell proliferation	GO:0072089	4	0.014
regulation of stem cell proliferation	GO:0072091	2	0.014
positive regulation of nucleotide catabolic process	GO:0030813	1	0.014
modification dependent protein catabolic process	GO:0019941	3	0.013
pharyngeal muscle development	GO:0043282	4	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.013
negative regulation of gene expression	GO:0010629	65	0.013
maintenance of location	GO:0051235	4	0.013
organelle assembly	GO:0070925	110	0.013	Worm
regulation of wound healing	GO:0061041	2	0.013
negative regulation of apoptotic process	GO:0043066	55	0.013
positive regulation of rna metabolic process	GO:0051254	59	0.013
sensory organ development	GO:0007423	393	0.013
localization of cell	GO:0051674	244	0.013
protein import into nucleus	GO:0006606	3	0.013
positive regulation of mrna processing	GO:0050685	1	0.013
eye morphogenesis	GO:0048592	144	0.013
establishment of localization in cell	GO:0051649	77	0.013
cellular amine metabolic process	GO:0044106	2	0.013
rna 3 end processing	GO:0031123	2	0.013
mitotic cell cycle process	GO:1903047	48	0.012	Fly
macromolecular complex subunit organization	GO:0043933	74	0.012	Worm Fly
positive regulation of cell death	GO:0010942	29	0.012
nucleoside monophosphate catabolic process	GO:0009125	4	0.012
regulation of cellular protein metabolic process	GO:0032268	52	0.012
cell motility	GO:0048870	244	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.012
single organism behavior	GO:0044708	24	0.012
axon development	GO:0061564	166	0.012
striated muscle cell differentiation	GO:0051146	129	0.012	Worm
single organism reproductive process	GO:0044702	40	0.012	Worm
spermatid differentiation	GO:0048515	2	0.012
regulation of cellular ketone metabolic process	GO:0010565	7	0.012
negative regulation of cell death	GO:0060548	60	0.012
establishment of vesicle localization	GO:0051650	24	0.012
negative regulation of metabolic process	GO:0009892	86	0.012
eye development	GO:0001654	277	0.012
spliceosomal complex assembly	GO:0000245	1	0.012
regulation of cellular amino acid metabolic process	GO:0006521	0	0.012
meiotic cell cycle	GO:0051321	5	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.012
single organism localization	GO:1902578	225	0.011
cell migration	GO:0016477	237	0.011
skin development	GO:0043588	54	0.011
carboxylic acid metabolic process	GO:0019752	22	0.011
protein targeting to nucleus	GO:0044744	3	0.011
behavior	GO:0007610	74	0.011	Worm
g1 s transition of mitotic cell cycle	GO:0000082	1	0.011
negative regulation of cellular metabolic process	GO:0031324	77	0.011
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.011
cell fate commitment	GO:0045165	99	0.011
regulation of reproductive process	GO:2000241	4	0.011
multi organism cellular process	GO:0044764	2	0.011
regulation of cellular amine metabolic process	GO:0033238	0	0.011
muscle cell development	GO:0055001	115	0.011	Worm
amine metabolic process	GO:0009308	2	0.011
ribosomal small subunit biogenesis	GO:0042274	2	0.011
proteolysis	GO:0006508	38	0.011
aromatic compound catabolic process	GO:0019439	15	0.011
establishment of localization	GO:0051234	244	0.011	Worm
anterior posterior pattern specification	GO:0009952	152	0.011
regulation of developmental process	GO:0050793	247	0.011
negative regulation of mrna metabolic process	GO:1903312	3	0.011
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.011
zymogen activation	GO:0031638	3	0.011
striated muscle cell development	GO:0055002	108	0.011	Worm
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.011
regulation of hydrolase activity	GO:0051336	28	0.011
ncrna catabolic process	GO:0034661	1	0.011
rna transport	GO:0050658	2	0.011
oxoacid metabolic process	GO:0043436	31	0.011
cellular protein modification process	GO:0006464	100	0.010
regulation of protein binding	GO:0043393	3	0.010
negative regulation of translation	GO:0017148	1	0.010
response to glucose	GO:0009749	3	0.010
organic acid metabolic process	GO:0006082	31	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.010
regulation of binding	GO:0051098	3	0.010
negative regulation of macromolecule metabolic process	GO:0010605	76	0.010
positive regulation of transcription dna templated	GO:0045893	57	0.010
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.010
catabolic process	GO:0009056	32	0.010
regulation of receptor activity	GO:0010469	2	0.010
small molecule metabolic process	GO:0044281	77	0.010
regulation of peptidase activity	GO:0052547	23	0.010

sf3a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.022
disease of cellular proliferation	DOID:14566	0.022
disease of anatomical entity	DOID:7	0.018

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