IMP: Integrative Multi-species Prediction

Danio rerio

14 known processes

isl2b

islet2b

(Aliases: isl3,zgc:109840,ISL-3,islet 3,zfIsl-3)

Entrez: 30151
ZFIN: ZDB-GENE-990415-133
Ensembl: ENSDARG00000053499
UniProtKB: P53407

Process Predictions
Disease Predictions

isl2b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
generation of neurons	GO:0048699	385	0.278	Zebrafish Mouse Fly
response to external stimulus	GO:0009605	264	0.217	Zebrafish Mouse Fly
signal transduction	GO:0007165	455	0.198	Fly
neuron development	GO:0048666	262	0.176	Zebrafish Mouse Fly
cell projection morphogenesis	GO:0048858	244	0.150	Zebrafish Mouse Fly
response to chemical	GO:0042221	320	0.147	Zebrafish Mouse Fly
cellular macromolecule metabolic process	GO:0044260	391	0.142	Fly
establishment of localization	GO:0051234	244	0.141
regulation of primary metabolic process	GO:0080090	311	0.140	Fly
positive regulation of biological process	GO:0048518	253	0.136	Fly
brain development	GO:0007420	293	0.133	Zebrafish
central nervous system development	GO:0007417	387	0.133	Zebrafish Mouse
response to stress	GO:0006950	263	0.122
axon guidance	GO:0007411	86	0.114	Zebrafish Mouse Fly
regulation of response to stimulus	GO:0048583	269	0.114
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.113	Fly
macromolecule biosynthetic process	GO:0009059	227	0.111	Fly
regulation of signaling	GO:0023051	235	0.109
cell part morphogenesis	GO:0032990	246	0.107	Zebrafish Mouse Fly
neuron differentiation	GO:0030182	353	0.105	Zebrafish Mouse Fly
cellular component morphogenesis	GO:0032989	336	0.104	Zebrafish Mouse Fly
regulation of biosynthetic process	GO:0009889	250	0.104	Fly
nucleic acid templated transcription	GO:0097659	181	0.099	Fly
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.099	Fly
cell morphogenesis	GO:0000902	289	0.096	Zebrafish Mouse Fly
immune system process	GO:0002376	241	0.095	Fly
ion transport	GO:0006811	114	0.092
head development	GO:0060322	303	0.092	Zebrafish Worm
negative regulation of biological process	GO:0048519	304	0.090	Mouse Fly
positive regulation of cellular process	GO:0048522	201	0.089	Fly
gene expression	GO:0010467	252	0.088	Zebrafish Fly
regulation of transcription dna templated	GO:0006355	213	0.087	Fly
growth	GO:0040007	174	0.087	Zebrafish
regulation of cellular metabolic process	GO:0031323	320	0.086	Fly
neuron projection morphogenesis	GO:0048812	161	0.086	Zebrafish Mouse Fly
organic substance biosynthetic process	GO:1901576	289	0.083	Fly
transport	GO:0006810	220	0.081
regulation of cell communication	GO:0010646	232	0.079
nucleic acid metabolic process	GO:0090304	244	0.079	Fly
nucleobase containing compound metabolic process	GO:0006139	274	0.078	Fly
positive regulation of transport	GO:0051050	2	0.078
cell growth	GO:0016049	57	0.078	Zebrafish
cellular component movement	GO:0006928	335	0.077	Zebrafish Mouse Fly
regulation of developmental process	GO:0050793	247	0.077	Mouse
single organism transport	GO:0044765	206	0.077
regulation of macromolecule metabolic process	GO:0060255	317	0.077	Zebrafish Fly
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.076	Zebrafish Mouse Fly
larval development	GO:0002164	2	0.075	Worm
system process	GO:0003008	185	0.075	Zebrafish Worm
negative regulation of cellular process	GO:0048523	283	0.074	Mouse
hematopoietic or lymphoid organ development	GO:0048534	191	0.073	Fly
heterocycle biosynthetic process	GO:0018130	215	0.072	Fly
aging	GO:0007568	2	0.071
regulation of rna metabolic process	GO:0051252	224	0.070	Fly
cellular macromolecule biosynthetic process	GO:0034645	224	0.069	Fly
biosynthetic process	GO:0009058	294	0.069	Fly
cellular component biogenesis	GO:0044085	178	0.068
morphogenesis of an epithelium	GO:0002009	333	0.064	Zebrafish Fly
regulation of cell death	GO:0010941	103	0.064
regulation of gene expression	GO:0010468	265	0.064	Zebrafish Fly
regulation of nucleic acid templated transcription	GO:1903506	213	0.063	Fly
cell projection organization	GO:0030030	284	0.062	Zebrafish Mouse Fly
vasculature development	GO:0001944	278	0.062
rna biosynthetic process	GO:0032774	181	0.062	Fly
localization of cell	GO:0051674	244	0.062
chordate embryonic development	GO:0043009	271	0.059	Zebrafish
transmembrane transport	GO:0055085	120	0.058
locomotion	GO:0040011	313	0.058	Zebrafish Mouse Worm Fly
meiotic nuclear division	GO:0007126	4	0.058
hemopoiesis	GO:0030097	183	0.058
response to carbohydrate	GO:0009743	3	0.058
ion transmembrane transport	GO:0034220	91	0.057
cellular component assembly	GO:0022607	170	0.057
regulation of nitrogen compound metabolic process	GO:0051171	251	0.056	Fly
response to drug	GO:0042493	3	0.056
embryonic organ development	GO:0048568	381	0.055	Zebrafish
regulation of biological quality	GO:0065008	263	0.055	Fly
stem cell division	GO:0017145	1	0.054
synaptic transmission	GO:0007268	35	0.053
cellular biosynthetic process	GO:0044249	286	0.053	Fly
regulation of multicellular organismal process	GO:0051239	277	0.053	Zebrafish Mouse
nitrogen compound metabolic process	GO:0006807	319	0.053	Fly
cell surface receptor signaling pathway	GO:0007166	325	0.052	Fly
guanosine containing compound metabolic process	GO:1901068	4	0.051
angiogenesis	GO:0001525	158	0.051
regulation of neurogenesis	GO:0050767	87	0.050	Mouse
regulation of cellular ketone metabolic process	GO:0010565	7	0.050
guanosine containing compound catabolic process	GO:1901069	2	0.049
b cell differentiation	GO:0030183	1	0.049
regulation of reproductive process	GO:2000241	4	0.046
regulation of cellular biosynthetic process	GO:0031326	245	0.046	Fly
regulation of dendrite development	GO:0050773	3	0.046
nucleobase containing compound biosynthetic process	GO:0034654	205	0.045	Fly
axon development	GO:0061564	166	0.045	Zebrafish Mouse Fly
nuclear transport	GO:0051169	4	0.045
multi organism process	GO:0051704	134	0.045
multicellular organism growth	GO:0035264	4	0.044
programmed cell death	GO:0012501	119	0.044
chemotaxis	GO:0006935	104	0.044	Zebrafish Mouse Fly
regulation of cell differentiation	GO:0045595	142	0.044	Mouse
rna metabolic process	GO:0016070	219	0.044	Fly
organic cyclic compound metabolic process	GO:1901360	301	0.043	Fly
regulation of cellular amine metabolic process	GO:0033238	0	0.043
regulation of synapse organization	GO:0050807	3	0.042
regulation of programmed cell death	GO:0043067	101	0.042
gtp metabolic process	GO:0046039	4	0.042
regulation of blood circulation	GO:1903522	32	0.041	Zebrafish
nucleocytoplasmic transport	GO:0006913	4	0.041
immune system development	GO:0002520	191	0.041	Fly
blood vessel morphogenesis	GO:0048514	216	0.041
regulation of establishment of protein localization	GO:0070201	4	0.041
endocrine system development	GO:0035270	65	0.041	Zebrafish
maintenance of location	GO:0051235	4	0.040
cellular aromatic compound metabolic process	GO:0006725	295	0.040	Fly
synaptic growth at neuromuscular junction	GO:0051124	2	0.040
transcription dna templated	GO:0006351	181	0.040	Fly
developmental growth involved in morphogenesis	GO:0060560	86	0.040	Zebrafish
regulation of nucleoside metabolic process	GO:0009118	2	0.040
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.039	Fly
cation transport	GO:0006812	81	0.039
cell substrate adhesion	GO:0031589	4	0.039
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.039	Fly
chemosensory behavior	GO:0007635	1	0.039
negative regulation of cell communication	GO:0010648	96	0.039
skeletal system development	GO:0001501	181	0.039
skeletal system morphogenesis	GO:0048705	102	0.038
positive regulation of cellular biosynthetic process	GO:0031328	68	0.038	Fly
single organism metabolic process	GO:0044710	217	0.038
metal ion transport	GO:0030001	58	0.038
taxis	GO:0042330	109	0.038	Zebrafish Mouse Fly
positive regulation of signaling	GO:0023056	56	0.038
regulation of metabolic process	GO:0019222	359	0.037	Zebrafish Fly
regulation of synaptic plasticity	GO:0048167	1	0.037
developmental growth	GO:0048589	166	0.037	Zebrafish
carboxylic acid metabolic process	GO:0019752	22	0.036
regulation of cytoplasmic transport	GO:1903649	4	0.036
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.036	Fly
cellular ketone metabolic process	GO:0042180	11	0.035
axonogenesis	GO:0007409	152	0.035	Zebrafish Mouse Fly
monovalent inorganic cation transport	GO:0015672	42	0.035
regulation of multicellular organism growth	GO:0040014	4	0.035
embryonic organ morphogenesis	GO:0048562	274	0.035	Zebrafish
response to nutrient	GO:0007584	3	0.035
multicellular organismal response to stress	GO:0033555	2	0.035
multicellular organismal signaling	GO:0035637	22	0.035
muscle cell differentiation	GO:0042692	139	0.034	Zebrafish Fly
cellular response to nutrient levels	GO:0031669	2	0.034
synaptic transmission cholinergic	GO:0007271	4	0.034
regulation of signal transduction	GO:0009966	225	0.034
aromatic compound biosynthetic process	GO:0019438	217	0.034	Fly
regulation of rna biosynthetic process	GO:2001141	213	0.034	Fly
cellular modified amino acid metabolic process	GO:0006575	3	0.033
cartilage development	GO:0051216	96	0.033
amine metabolic process	GO:0009308	2	0.033
cell morphogenesis involved in differentiation	GO:0000904	195	0.033	Zebrafish Mouse Fly
central nervous system neuron differentiation	GO:0021953	74	0.033	Zebrafish Mouse
cell fate commitment	GO:0045165	99	0.033	Zebrafish Mouse Fly
regulation of dendrite morphogenesis	GO:0048814	3	0.033
mesenchyme development	GO:0060485	127	0.033
camera type eye development	GO:0043010	222	0.032	Zebrafish
membrane fusion	GO:0061025	2	0.032
regulation of synapse assembly	GO:0051963	3	0.032
stem cell differentiation	GO:0048863	117	0.032
regulation of cell activation	GO:0050865	1	0.031
positive regulation of catabolic process	GO:0009896	4	0.031
organic cyclic compound biosynthetic process	GO:1901362	223	0.031	Fly
cellular response to chemical stimulus	GO:0070887	157	0.031
pancreas development	GO:0031016	84	0.030
cell motility	GO:0048870	244	0.030
behavior	GO:0007610	74	0.030	Zebrafish
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.030
cellular amino acid metabolic process	GO:0006520	7	0.030
cellular localization	GO:0051641	97	0.030
gtp catabolic process	GO:0006184	2	0.030
nuclear import	GO:0051170	3	0.029
apoptotic process	GO:0006915	116	0.029
cellular response to extracellular stimulus	GO:0031668	2	0.029
cell migration	GO:0016477	237	0.029
digestive system development	GO:0055123	289	0.029
negative regulation of response to stimulus	GO:0048585	104	0.029
b cell activation	GO:0042113	2	0.028
stem cell proliferation	GO:0072089	4	0.028
death	GO:0016265	121	0.028
embryonic skeletal system development	GO:0048706	97	0.028
gland development	GO:0048732	143	0.028	Fly
regulation of protein transport	GO:0051223	3	0.028
regulation of cellular component organization	GO:0051128	86	0.028
negative regulation of apoptotic process	GO:0043066	55	0.028
organelle organization	GO:0006996	227	0.027
embryonic skeletal system morphogenesis	GO:0048704	93	0.027
regulation of purine nucleotide catabolic process	GO:0033121	2	0.027
regulation of carbohydrate metabolic process	GO:0006109	4	0.027
regulation of gtp catabolic process	GO:0033124	2	0.027
cellular amine metabolic process	GO:0044106	2	0.027
cellular response to starvation	GO:0009267	1	0.027
positive regulation of nucleoside metabolic process	GO:0045979	1	0.027
transmission of nerve impulse	GO:0019226	19	0.027
organic acid metabolic process	GO:0006082	31	0.027
single organism nuclear import	GO:1902593	3	0.027
protein localization to nucleus	GO:0034504	3	0.027
eye development	GO:0001654	277	0.027	Zebrafish
regulation of apoptotic process	GO:0042981	98	0.026
organonitrogen compound metabolic process	GO:1901564	74	0.026
neuron projection guidance	GO:0097485	86	0.026	Zebrafish Mouse Fly
regulation of multicellular organismal development	GO:2000026	223	0.026	Mouse
positive regulation of cellular metabolic process	GO:0031325	94	0.026	Fly
positive regulation of cellular catabolic process	GO:0031331	3	0.026
cell proliferation	GO:0008283	80	0.026
cation transmembrane transport	GO:0098655	65	0.026
protein import into nucleus	GO:0006606	3	0.026
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.026
regulation of circadian rhythm	GO:0042752	4	0.025
single organism localization	GO:1902578	225	0.025
cellular nitrogen compound metabolic process	GO:0034641	290	0.025	Fly
intracellular signal transduction	GO:0035556	85	0.025
regulation of jak stat cascade	GO:0046425	3	0.025
positive regulation of metabolic process	GO:0009893	108	0.025	Fly
establishment of protein localization to organelle	GO:0072594	4	0.025
neurological system process	GO:0050877	62	0.024
hepaticobiliary system development	GO:0061008	98	0.024
cell cell signaling	GO:0007267	52	0.024
regulation of metal ion transport	GO:0010959	4	0.024
positive regulation of cell communication	GO:0010647	56	0.024
negative regulation of programmed cell death	GO:0043069	58	0.024
regulation of neuron differentiation	GO:0045664	56	0.024	Mouse
synaptic vesicle localization	GO:0097479	1	0.024
regulation of cellular amino acid metabolic process	GO:0006521	0	0.024
oxoacid metabolic process	GO:0043436	31	0.023
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.023	Fly
positive regulation of macromolecule metabolic process	GO:0010604	93	0.023	Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.023	Fly
protein import	GO:0017038	3	0.023
negative regulation of signal transduction	GO:0009968	94	0.022
carbohydrate homeostasis	GO:0033500	1	0.022
organelle fusion	GO:0048284	3	0.022
negative regulation of mapk cascade	GO:0043409	4	0.022
cellular carbohydrate metabolic process	GO:0044262	4	0.022
leukocyte proliferation	GO:0070661	1	0.022
negative regulation of signaling	GO:0023057	96	0.022
homeostasis of number of cells	GO:0048872	62	0.022
regulation of cellular component movement	GO:0051270	55	0.022
neuronal action potential	GO:0019228	18	0.022
single organism membrane fusion	GO:0044801	2	0.021
lipid storage	GO:0019915	1	0.021
ameboidal type cell migration	GO:0001667	143	0.021
regulation of intracellular protein transport	GO:0033157	3	0.021
response to abiotic stimulus	GO:0009628	122	0.021	Zebrafish
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	22	0.021
positive regulation of response to stimulus	GO:0048584	80	0.021
sensory organ morphogenesis	GO:0090596	200	0.021	Zebrafish
adult behavior	GO:0030534	2	0.021
transcription from rna polymerase ii promoter	GO:0006366	80	0.021	Fly
sprouting angiogenesis	GO:0002040	53	0.021
regulation of meiotic cell cycle	GO:0051445	1	0.021
regulation of cell substrate adhesion	GO:0010810	1	0.021
striated muscle cell differentiation	GO:0051146	129	0.021	Zebrafish
protein modification process	GO:0036211	100	0.021
cellular response to organic substance	GO:0071310	105	0.021
organic substance transport	GO:0071702	58	0.020
mononuclear cell proliferation	GO:0032943	1	0.020
small molecule metabolic process	GO:0044281	77	0.020
regulation of heart contraction	GO:0008016	32	0.020	Zebrafish
positive regulation of signal transduction	GO:0009967	56	0.020
neuromuscular synaptic transmission	GO:0007274	2	0.020
regulation of cell matrix adhesion	GO:0001952	1	0.020
sensory perception of chemical stimulus	GO:0007606	3	0.020
embryo development ending in birth or egg hatching	GO:0009792	271	0.020	Zebrafish Fly
protein targeting to nucleus	GO:0044744	3	0.020
cytoskeleton organization	GO:0007010	96	0.020
cell matrix adhesion	GO:0007160	4	0.020
myeloid cell differentiation	GO:0030099	86	0.020
positive regulation of gene expression	GO:0010628	71	0.020	Fly
positive regulation of purine nucleotide catabolic process	GO:0033123	1	0.020
positive regulation of cellular amine metabolic process	GO:0033240	0	0.020
regulation of gtpase activity	GO:0043087	2	0.020
sensory organ development	GO:0007423	393	0.020	Zebrafish Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.020
neuroblast proliferation	GO:0007405	2	0.020
response to endogenous stimulus	GO:0009719	83	0.020
regulation of localization	GO:0032879	104	0.020
heterocycle metabolic process	GO:0046483	290	0.019	Fly
camera type eye morphogenesis	GO:0048593	108	0.019	Zebrafish
immune effector process	GO:0002252	23	0.019
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.019
motor neuron axon guidance	GO:0008045	23	0.019	Fly
cell death	GO:0008219	121	0.019
regulation of immune system process	GO:0002682	34	0.019
production of molecular mediator of immune response	GO:0002440	2	0.019
regulation of nucleocytoplasmic transport	GO:0046822	2	0.019
peripheral nervous system neuron differentiation	GO:0048934	28	0.019	Zebrafish
biological adhesion	GO:0022610	40	0.019
cellular response to external stimulus	GO:0071496	2	0.019
negative regulation of dna replication	GO:0008156	2	0.019
heart development	GO:0007507	313	0.019	Zebrafish Fly
exocytosis	GO:0006887	1	0.019
glial cell differentiation	GO:0010001	42	0.018
negative regulation of protein phosphorylation	GO:0001933	4	0.018
homeostatic process	GO:0042592	142	0.018	Fly
rna localization	GO:0006403	4	0.018
regulation of anatomical structure morphogenesis	GO:0022603	130	0.018
regulation of locomotion	GO:0040012	55	0.018
lymphocyte proliferation	GO:0046651	1	0.018
mesenchymal cell differentiation	GO:0048762	87	0.018
neuron projection development	GO:0031175	180	0.018	Zebrafish Mouse Fly
vasculogenesis	GO:0001570	41	0.018
liver development	GO:0001889	96	0.018
adherens junction organization	GO:0034332	4	0.018
positive regulation of cellular component biogenesis	GO:0044089	3	0.018
glucose homeostasis	GO:0042593	1	0.018
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.018	Fly
regulation of calcium ion transport	GO:0051924	2	0.018
negative regulation of rna metabolic process	GO:0051253	48	0.017
response to organic substance	GO:0010033	153	0.017
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.017
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.017
neurotransmitter transport	GO:0006836	2	0.017
mitochondrion organization	GO:0007005	4	0.017
regulation of transmembrane transporter activity	GO:0022898	2	0.017
inorganic ion transmembrane transport	GO:0098660	57	0.017
positive regulation of cytosolic calcium ion concentration	GO:0007204	4	0.017
macromolecule modification	GO:0043412	111	0.017
cytokinesis	GO:0000910	3	0.017
positive regulation of biosynthetic process	GO:0009891	68	0.017	Fly
blood vessel development	GO:0001568	246	0.017
cell cycle g1 s phase transition	GO:0044843	1	0.017
antimicrobial humoral response	GO:0019730	2	0.017
negative regulation of metabolic process	GO:0009892	86	0.017
phosphate containing compound metabolic process	GO:0006796	108	0.017
cilium organization	GO:0044782	71	0.017
establishment of synaptic vesicle localization	GO:0097480	1	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.016
peripheral nervous system development	GO:0007422	55	0.016	Zebrafish
endocrine pancreas development	GO:0031018	27	0.016	Zebrafish
neurotransmitter secretion	GO:0007269	2	0.016
endosomal transport	GO:0016197	2	0.016
chemical homeostasis	GO:0048878	49	0.016
positive regulation of secretion	GO:0051047	1	0.016
regulation of cell projection organization	GO:0031344	44	0.016
connective tissue development	GO:0061448	99	0.016
action potential	GO:0001508	19	0.016
axon ensheathment in central nervous system	GO:0032291	2	0.016
tissue regeneration	GO:0042246	74	0.016
cell cycle	GO:0007049	93	0.016
tissue remodeling	GO:0048771	4	0.016
response to biotic stimulus	GO:0009607	97	0.016
positive regulation of immune effector process	GO:0002699	3	0.016
protein localization to plasma membrane	GO:0072659	1	0.016
eye morphogenesis	GO:0048592	144	0.016	Zebrafish
spinal cord development	GO:0021510	46	0.016	Zebrafish Mouse
regulation of nucleotide catabolic process	GO:0030811	2	0.016
meiotic cell cycle process	GO:1903046	3	0.016
negative regulation of developmental process	GO:0051093	65	0.016	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	3	0.016
protein metabolic process	GO:0019538	183	0.016
synaptic target recognition	GO:0008039	1	0.015
positive regulation of secretion by cell	GO:1903532	1	0.015
negative regulation of macromolecule metabolic process	GO:0010605	76	0.015
hormone secretion	GO:0046879	2	0.015
central nervous system neuron development	GO:0021954	29	0.015
cognition	GO:0050890	1	0.015
response to organic cyclic compound	GO:0014070	51	0.015
heart contraction	GO:0060047	71	0.015	Zebrafish
single organism organelle organization	GO:1902589	199	0.015
tube morphogenesis	GO:0035239	349	0.015	Zebrafish
oocyte anterior posterior axis specification	GO:0007314	4	0.015
protein localization	GO:0008104	40	0.015
alpha amino acid metabolic process	GO:1901605	3	0.015
regulation of cellular carbohydrate metabolic process	GO:0010675	4	0.015
neural retina development	GO:0003407	49	0.015
macromolecular complex subunit organization	GO:0043933	74	0.015
fertilization	GO:0009566	3	0.015
regulation of binding	GO:0051098	3	0.015
positive regulation of cell activation	GO:0050867	1	0.015
neural crest cell differentiation	GO:0014033	72	0.015
synaptic vesicle transport	GO:0048489	1	0.015
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.015	Fly
regulation of ion transmembrane transporter activity	GO:0032412	2	0.014
cytoskeleton dependent cytokinesis	GO:0061640	3	0.014
regulation of transport	GO:0051049	45	0.014
regeneration	GO:0031099	91	0.014
regulation of blood vessel size	GO:0050880	2	0.014
regulation of inflammatory response	GO:0050727	2	0.014
sensory perception of pain	GO:0019233	1	0.014
neuron neuron synaptic transmission	GO:0007270	1	0.014
spermatid differentiation	GO:0048515	2	0.014
negative regulation of biosynthetic process	GO:0009890	55	0.014
developmental cell growth	GO:0048588	52	0.014	Zebrafish
muscle tissue development	GO:0060537	110	0.014	Zebrafish
regulation of cell development	GO:0060284	100	0.014	Mouse
forebrain development	GO:0030900	96	0.014	Zebrafish
epithelial tube morphogenesis	GO:0060562	148	0.014
regulation of mrna processing	GO:0050684	3	0.014
axon extension	GO:0048675	45	0.014	Zebrafish
cellular protein metabolic process	GO:0044267	129	0.014
blood circulation	GO:0008015	87	0.014	Zebrafish
regulation of tube size	GO:0035150	2	0.014
epiboly involved in gastrulation with mouth forming second	GO:0055113	35	0.014
negative regulation of multicellular organismal process	GO:0051241	69	0.014	Mouse
lymph vessel development	GO:0001945	27	0.014
negative regulation of cell death	GO:0060548	60	0.014
positive regulation of gtp catabolic process	GO:0033126	1	0.014
positive regulation of nucleotide catabolic process	GO:0030813	1	0.013
regulation of system process	GO:0044057	40	0.013	Zebrafish
positive regulation of rna metabolic process	GO:0051254	59	0.013	Fly
response to oxygen containing compound	GO:1901700	55	0.013
response to light stimulus	GO:0009416	46	0.013	Zebrafish
regulation of cell growth	GO:0001558	29	0.013
mechanosensory behavior	GO:0007638	2	0.013
response to other organism	GO:0051707	97	0.013
regulation of response to external stimulus	GO:0032101	31	0.013
response to external biotic stimulus	GO:0043207	97	0.013
locomotor rhythm	GO:0045475	3	0.013
forebrain cell migration	GO:0021885	1	0.013
negative regulation of kinase activity	GO:0033673	4	0.013
regulation of glial cell differentiation	GO:0045685	4	0.013
regulation of cell cycle	GO:0051726	52	0.013
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	2	0.013	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.013	Fly
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.013
negative regulation of dna metabolic process	GO:0051053	4	0.013
single organism intracellular transport	GO:1902582	25	0.013
segmentation	GO:0035282	97	0.013	Fly
gastrulation	GO:0007369	208	0.013
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.012
negative regulation of cellular biosynthetic process	GO:0031327	55	0.012
negative regulation of protein kinase activity	GO:0006469	4	0.012
central nervous system myelination	GO:0022010	2	0.012
retina development in camera type eye	GO:0060041	146	0.012	Zebrafish
branching morphogenesis of a nerve	GO:0048755	4	0.012
negative regulation of gene expression	GO:0010629	65	0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	4	0.012
muscle structure development	GO:0061061	196	0.012	Zebrafish Fly
cellular protein modification process	GO:0006464	100	0.012
carbohydrate derivative metabolic process	GO:1901135	61	0.012
cellular component assembly involved in morphogenesis	GO:0010927	107	0.012
response to ketone	GO:1901654	1	0.012
circulatory system process	GO:0003013	87	0.012	Zebrafish
kupffer s vesicle development	GO:0070121	50	0.012
peptidyl serine phosphorylation	GO:0018105	1	0.012
cell cycle arrest	GO:0007050	1	0.012
response to hexose	GO:0009746	3	0.012
cellular response to endogenous stimulus	GO:0071495	68	0.012
regulation of filopodium assembly	GO:0051489	2	0.012
photoreceptor cell development	GO:0042461	40	0.012
development of primary female sexual characteristics	GO:0046545	4	0.012
peptidyl threonine modification	GO:0018210	1	0.012
response to glucose	GO:0009749	3	0.012
protein heterooligomerization	GO:0051291	1	0.012
sodium ion transport	GO:0006814	24	0.012
protein stabilization	GO:0050821	2	0.011
embryonic skeletal joint development	GO:0072498	3	0.011
lymph vessel morphogenesis	GO:0036303	25	0.011
female gonad development	GO:0008585	4	0.011
establishment of localization in cell	GO:0051649	77	0.011
regulation of protein import into nucleus	GO:0042306	2	0.011
post embryonic organ development	GO:0048569	4	0.011
peptidyl serine modification	GO:0018209	2	0.011
microtubule polymerization or depolymerization	GO:0031109	3	0.011
endothelial cell fate commitment	GO:0060839	3	0.011
positive regulation of cell cycle	GO:0045787	3	0.011
defense response	GO:0006952	47	0.011
regulation of cytokine production	GO:0001817	3	0.011
lamellipodium organization	GO:0097581	1	0.011
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.011
cellular response to oxygen levels	GO:0071453	1	0.011
regulation of axon extension	GO:0030516	24	0.011
positive regulation of jak stat cascade	GO:0046427	2	0.011
negative regulation of catabolic process	GO:0009895	3	0.011
response to monosaccharide	GO:0034284	3	0.011
regulation of epithelial cell proliferation	GO:0050678	3	0.011
regulation of neuronal synaptic plasticity	GO:0048168	1	0.011
smooth muscle contraction	GO:0006939	2	0.011
regulation of ion transport	GO:0043269	22	0.011
regulation of neuron projection development	GO:0010975	40	0.011
stem cell maintenance	GO:0019827	4	0.011
proteasomal protein catabolic process	GO:0010498	2	0.011
heart process	GO:0003015	71	0.011	Zebrafish
regulation of transporter activity	GO:0032409	2	0.011
phosphorylation	GO:0016310	69	0.011
embryonic skeletal joint morphogenesis	GO:0060272	3	0.011
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.011
calcium mediated signaling	GO:0019722	2	0.010
peripheral nervous system neuron development	GO:0048935	22	0.010	Zebrafish
fin regeneration	GO:0031101	51	0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.010
neuron projection extension	GO:1990138	45	0.010	Zebrafish
heart morphogenesis	GO:0003007	156	0.010
actin filament based process	GO:0030029	64	0.010
inner ear development	GO:0048839	126	0.010	Zebrafish
regulation of microtubule cytoskeleton organization	GO:0070507	3	0.010
cellular component disassembly	GO:0022411	1	0.010

isl2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.062
disease of cellular proliferation	DOID:14566	0.024
cancer	DOID:162	0.022
organ system cancer	DOID:0050686	0.020
nervous system disease	DOID:863	0.011

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