Danio rerio

68 known processes

apex1

APEX nuclease (multifunctional DNA repair enzyme) 1

(Aliases: apex1a,wu:fc13d11,MGC113976,zgc:66204,hm:zehn1532)

apex1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleobase containing compound metabolic processGO:00061392740.707
Human Worm Fly
cellular aromatic compound metabolic processGO:00067252950.575
Human Worm Fly
cellular macromolecule biosynthetic processGO:00346452240.501
heterocycle metabolic processGO:00464832900.475
Human Worm Fly
cellular macromolecule metabolic processGO:00442603910.449
Human Worm Fly
regulation of nucleic acid templated transcriptionGO:19035062130.432
Human
regulation of nitrogen compound metabolic processGO:00511712510.394
Human
regulation of metabolic processGO:00192223590.369
single organism organelle organizationGO:19025891990.367
cellular nitrogen compound biosynthetic processGO:00442712180.363
regulation of nucleobase containing compound metabolic processGO:00192192500.322
Human
nucleic acid templated transcriptionGO:00976591810.320
nitrogen compound metabolic processGO:00068073190.302
Human Worm Fly
biosynthetic processGO:00090582940.273
regulation of rna biosynthetic processGO:20011412130.253
Human
positive regulation of chromatin modificationGO:190331010.239
regulation of cellular metabolic processGO:00313233200.235
Human
positive regulation of cellular processGO:00485222010.222
Human
cell morphogenesisGO:00009022890.220
organelle organizationGO:00069962270.217
organic substance biosynthetic processGO:19015762890.217
rna biosynthetic processGO:00327741810.212
nucleobase containing compound biosynthetic processGO:00346542050.211
mitotic cell cycleGO:0000278640.207
nucleic acid metabolic processGO:00903042440.203
Human Worm Fly
purine nucleoside monophosphate catabolic processGO:000912840.194
single organism metabolic processGO:00447102170.189
Human Worm
regulation of macromolecule biosynthetic processGO:00105562250.178
Human
organic cyclic compound metabolic processGO:19013603010.175
Human Worm Fly
regulation of transcription dna templatedGO:00063552130.173
negative regulation of ras protein signal transductionGO:004658010.164
positive regulation of nitrogen compound metabolic processGO:0051173690.160
Human
muscle structure developmentGO:00610611960.154
response to stressGO:00069502630.144
Human Worm Fly
regulation of biosynthetic processGO:00098892500.139
Human
organic cyclic compound biosynthetic processGO:19013622230.134
rna metabolic processGO:00160702190.133
heterocycle biosynthetic processGO:00181302150.133
transcription from rna polymerase ii promoterGO:0006366800.130
negative regulation of biological processGO:00485193040.127
ribonucleoside monophosphate catabolic processGO:000915840.126
regulation of cellular macromolecule biosynthetic processGO:20001122220.121
transcription dna templatedGO:00063511810.121
positive regulation of nucleobase containing compound metabolic processGO:0045935690.116
Human
macromolecule biosynthetic processGO:00090592270.116
cytoskeleton organizationGO:0007010960.111
regulation of multicellular organism growthGO:004001440.107
cytokinesisGO:000091030.107
protein acetylationGO:000647320.107
cellular nitrogen compound metabolic processGO:00346412900.105
Human Worm Fly
cellular component morphogenesisGO:00329893360.104
digestive tract morphogenesisGO:00485462310.102
regulation of gene expressionGO:00104682650.100
response to chemicalGO:00422213200.098
negative regulation of rna metabolic processGO:0051253480.098
negative regulation of cellular processGO:00485232830.095
negative regulation of macromolecule biosynthetic processGO:0010558480.092
small molecule metabolic processGO:0044281770.092
regulation of cellular biosynthetic processGO:00313262450.091
Human
cell projection organizationGO:00300302840.090
positive regulation of metabolic processGO:00098931080.087
spindle assemblyGO:005122520.081
regulation of rna metabolic processGO:00512522240.080
Human
covalent chromatin modificationGO:0016569200.080
neuron developmentGO:00486662620.079
positive regulation of histone modificationGO:003105810.078
chromosome organizationGO:0051276310.077
generation of neuronsGO:00486993850.077
positive regulation of cell cycleGO:004578730.076
regulation of primary metabolic processGO:00800903110.074
Human
purine containing compound metabolic processGO:0072521290.074
protein complex localizationGO:003150310.072
cellular component assemblyGO:00226071700.072
gene expressionGO:00104672520.072
regulation of developmental processGO:00507932470.071
embryonic digestive tract developmentGO:004856640.070
positive regulation of cellular metabolic processGO:0031325940.069
Human
cell part morphogenesisGO:00329902460.068
positive regulation of macromolecule biosynthetic processGO:0010557590.068
positive regulation of biosynthetic processGO:0009891680.067
adult behaviorGO:003053420.066
nuclear transportGO:005116940.066
negative regulation of biosynthetic processGO:0009890550.066
positive regulation of dna metabolic processGO:005105410.066
Human
embryonic digestive tract morphogenesisGO:004855730.063
cell cycle g2 m phase transitionGO:004483940.063
cell projection morphogenesisGO:00488582440.062
positive regulation of transportGO:005105020.062
negative regulation of transcription dna templatedGO:0045892450.062
cell cycleGO:0007049930.061
digestive system developmentGO:00551232890.060
internal peptidyl lysine acetylationGO:001839320.060
regulation of macromolecule metabolic processGO:00602553170.059
cell cycle processGO:0022402530.058
embryonic organ developmentGO:00485683810.058
histone modificationGO:0016570200.056
negative regulation of macromolecule metabolic processGO:0010605760.056
organonitrogen compound metabolic processGO:1901564740.054
negative regulation of nitrogen compound metabolic processGO:0051172590.054
definitive hemopoiesisGO:0060216180.054
negative regulation of metabolic processGO:0009892860.054
peptidyl lysine acetylationGO:001839420.053
multicellular organism growthGO:003526440.053
dna metabolic processGO:0006259270.051
Human Worm Fly
regulation of biological qualityGO:00650082630.050
Human Mouse
peptidyl lysine methylationGO:001802230.050
striated muscle cell differentiationGO:00511461290.050
organelle fissionGO:0048285230.050
negative regulation of nucleobase containing compound metabolic processGO:0045934590.049
regulation of dna metabolic processGO:0051052110.048
Human
aromatic compound biosynthetic processGO:00194382170.048
positive regulation of chromosome organizationGO:200125210.045
nucleoside monophosphate catabolic processGO:000912540.044
phosphorus metabolic processGO:00067931090.044
larval developmentGO:000216420.044
Worm
protein acylationGO:004354330.044
negative regulation of cellular biosynthetic processGO:0031327550.043
negative regulation of nucleic acid templated transcriptionGO:1903507450.042
chemosensory behaviorGO:000763510.042
agingGO:000756820.042
regulation of cell deathGO:00109411030.041
regulation of histone methylationGO:003106030.041
ribonucleotide metabolic processGO:0009259270.040
cellular biosynthetic processGO:00442492860.040
positive regulation of nucleic acid templated transcriptionGO:1903508570.039
microtubule cytoskeleton organization involved in mitosisGO:190285010.039
mitotic cell cycle processGO:1903047480.039
muscle cell developmentGO:00550011150.039
positive regulation of biological processGO:00485182530.038
regulation of protein complex assemblyGO:004325430.037
cellular response to stressGO:0033554620.037
Human Worm Fly
regulation of transcription from rna polymerase ii promoterGO:00063571140.037
cell deathGO:00082191210.037
double strand break repairGO:000630230.036
regulation of circadian rhythmGO:004275240.036
eye developmentGO:00016542770.036
negative regulation of gene expressionGO:0010629650.035
neuron projection morphogenesisGO:00488121610.035
histone h3 k4 methylationGO:005156820.035
protein metabolic processGO:00195381830.035
mitotic dna integrity checkpointGO:004477440.035
multi organism processGO:00517041340.034
digestive tract developmentGO:00485652650.034
internal protein amino acid acetylationGO:000647520.034
regulation of programmed cell deathGO:00430671010.033
macromolecular complex subunit organizationGO:0043933740.033
cellular component biogenesisGO:00440851780.033
regulation of nucleocytoplasmic transportGO:004682220.032
intracellular signal transductionGO:0035556850.032
signal transductionGO:00071654550.031
negative regulation of chromosome organizationGO:200125110.031
regulation of cytoplasmic transportGO:190364940.031
negative regulation of small gtpase mediated signal transductionGO:005105810.031
positive regulation of cellular amine metabolic processGO:003324000.031
positive regulation of gene expressionGO:0010628710.031
behaviorGO:0007610740.030
dna catabolic processGO:000630810.030
Human Worm Fly
protein complex assemblyGO:0006461300.030
actin filament based processGO:0030029640.030
regulation of signalingGO:00230512350.029
atp catabolic processGO:000620040.029
muscle cell differentiationGO:00426921390.029
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.029
deathGO:00162651210.029
nuclear exportGO:005116810.029
cellular protein complex assemblyGO:0043623190.028
neuron differentiationGO:00301823530.028
nuclear envelope organizationGO:000699820.028
amine metabolic processGO:000930820.028
mitotic dna damage checkpointGO:004477340.028
system processGO:00030081850.028
regulation of multicellular organismal developmentGO:20000262230.028
mitotic cytokinesisGO:000028130.028
chromatin organizationGO:0006325220.028
nucleobase containing small molecule metabolic processGO:0055086320.027
cellular protein metabolic processGO:00442671290.027
regulation of cellular response to oxidative stressGO:190040720.027
phosphate containing compound metabolic processGO:00067961080.027
microtubule based processGO:0007017600.027
positive regulation of carbohydrate metabolic processGO:004591310.027
neurological system processGO:0050877620.027
peptidyl lysine dimethylationGO:001802710.027
regulation of cellular amino acid metabolic processGO:000652100.026
protein alkylationGO:0008213130.026
i kappab kinase nf kappab signalingGO:000724940.026
regulation of chromatin organizationGO:190227550.025
nuclear migrationGO:000709730.025
negative regulation of cellular metabolic processGO:0031324770.025
positive regulation of rna metabolic processGO:0051254590.025
lipid storageGO:001991510.025
histone methylationGO:0016571130.025
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.025
tube morphogenesisGO:00352393490.025
organophosphate metabolic processGO:0019637370.024
cell fate commitmentGO:0045165990.024
neuron projection developmentGO:00311751800.024
protein modification processGO:00362111000.024
cell morphogenesis involved in differentiationGO:00009041950.024
positive regulation of cellular biosynthetic processGO:0031328680.024
cellular amine metabolic processGO:004410620.023
regulation of cellular ketone metabolic processGO:001056570.023
cell proliferationGO:0008283800.023
ribose phosphate metabolic processGO:0019693270.023
ras protein signal transductionGO:000726570.023
macromolecule modificationGO:00434121110.023
Human
camera type eye developmentGO:00430102220.022
exocrine pancreas developmentGO:0031017280.022
peptidyl lysine trimethylationGO:001802310.022
retina morphogenesis in camera type eyeGO:0060042790.022
protein targeting to nucleusGO:004474430.022
protein localizationGO:0008104400.022
establishment of protein localization to organelleGO:007259440.021
developmental growthGO:00485891660.021
photoreceptor cell developmentGO:0042461400.021
regulation of cell communicationGO:00106462320.021
protein localization to nucleusGO:003450430.021
rna transportGO:005065820.021
regulation of dna replicationGO:000627530.021
cell morphogenesis involved in neuron differentiationGO:00486671630.021
sensory organ morphogenesisGO:00905962000.021
protein homooligomerizationGO:005126030.020
locomotionGO:00400113130.020
histone h3 k9 methylationGO:005156750.020
convergent extension involved in gastrulationGO:0060027710.020
liver developmentGO:0001889960.020
negative regulation of myeloid cell differentiationGO:004563810.020
muscle organ developmentGO:00075171010.020
hemopoiesisGO:00300971830.019
g2 m transition of mitotic cell cycleGO:000008640.019
cellular macromolecule localizationGO:0070727210.019
positive regulation of rna biosynthetic processGO:1902680570.019
hematopoietic or lymphoid organ developmentGO:00485341910.019
retina development in camera type eyeGO:00600411460.019
response to corticosteroidGO:003196010.019
chromatin modificationGO:0016568210.018
regulation of bindingGO:005109830.018
protein complex subunit organizationGO:0071822460.018
regulation of multicellular organismal processGO:00512392770.018
cellular ketone metabolic processGO:0042180110.018
response to nutrientGO:000758430.018
nucleus organizationGO:000699770.018
positive regulation of cellular amino acid metabolic processGO:004576400.018
transportGO:00068102200.018
regulation of myotube differentiationGO:001083020.018
mitotic nuclear divisionGO:0007067180.018
regulation of signal transductionGO:00099662250.018
cellular component movementGO:00069283350.018
immune system processGO:00023762410.017
regulation of cellular amine metabolic processGO:003323800.017
regulation of chromosome segregationGO:005198310.017
cytoskeleton dependent cytokinesisGO:006164030.017
cellular protein modification processGO:00064641000.017
apoptotic processGO:00069151160.017
spindle assembly involved in mitosisGO:009030710.017
sensory organ developmentGO:00074233930.017
determination of bilateral symmetryGO:00098552040.017
immune system developmentGO:00025201910.017
telomere organizationGO:003220010.017
alternative mrna splicing via spliceosomeGO:000038010.017
regulation of intracellular signal transductionGO:1902531570.017
positive regulation of macromolecule metabolic processGO:0010604930.016
fertilizationGO:000956630.016
regulation of cellular carbohydrate metabolic processGO:001067540.016
negative regulation of chromatin modificationGO:190330910.016
regulation of translational initiationGO:000644610.016
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.016
cellular component assembly involved in morphogenesisGO:00109271070.016
morphogenesis of an epitheliumGO:00020093330.016
mitochondrion organizationGO:000700540.016
cellular response to oxygen levelsGO:007145310.016
heart morphogenesisGO:00030071560.016
macromolecular complex assemblyGO:0065003350.015
muscle tissue developmentGO:00605371100.015
negative regulation of i kappab kinase nf kappab signalingGO:004312410.015
skeletal muscle tissue developmentGO:0007519670.015
single organism reproductive processGO:0044702400.015
meiotic nuclear divisionGO:000712640.015
camera type eye morphogenesisGO:00485931080.015
cellular macromolecular complex assemblyGO:0034622240.015
purine ribonucleoside monophosphate catabolic processGO:000916940.015
cellular protein complex localizationGO:003462910.015
cellular carbohydrate metabolic processGO:004426240.015
protein complex biogenesisGO:0070271300.014
programmed cell deathGO:00125011190.014
axon developmentGO:00615641660.014
cell migrationGO:00164772370.014
growthGO:00400071740.014
regulation of cell shapeGO:000836010.014
regulation of microtubule cytoskeleton organizationGO:007050730.014
cellular response to extracellular stimulusGO:003166820.014
regulation of dna recombinationGO:000001820.014
regulation of organelle organizationGO:0033043290.014
positive regulation of transcription dna templatedGO:0045893570.014
mitotic g2 dna damage checkpointGO:000709530.014
nucleocytoplasmic transportGO:000691340.014
segmentationGO:0035282970.014
regulation of histone h3 k9 methylationGO:005157020.014
response to abiotic stimulusGO:00096281220.014
cell divisionGO:0051301200.014
oxoacid metabolic processGO:0043436310.014
regulation of cell differentiationGO:00455951420.013
axonogenesisGO:00074091520.013
cellular response to chemical stimulusGO:00708871570.013
striated muscle tissue developmentGO:00147061100.013
pancreas developmentGO:0031016840.013
cognitionGO:005089010.013
protein import into nucleusGO:000660630.013
negative regulation of dna metabolic processGO:005105340.013
negative regulation of dna replicationGO:000815620.013
mrna metabolic processGO:0016071200.013
adherens junction organizationGO:003433240.013
regulation of cellular component organizationGO:0051128860.013
negative regulation of rna biosynthetic processGO:1902679450.013
nucleic acid transportGO:005065720.013
positive regulation of cytoskeleton organizationGO:005149530.013
cell substrate adhesionGO:003158940.013
protein importGO:001703830.013
energy reserve metabolic processGO:000611220.013
negative regulation of rna splicingGO:003311910.013
protein polymerizationGO:005125840.013
regulation of histone modificationGO:003105650.013
cellular localizationGO:0051641970.012
proteasomal protein catabolic processGO:001049820.012
cell agingGO:000756920.012
regulation of cell cycleGO:0051726520.012
regionalizationGO:00030022740.012
protein stabilizationGO:005082120.012
positive regulation of rna splicingGO:003312010.012
organelle assemblyGO:00709251100.012
epidermal cell fate specificationGO:000995740.012
microtubule organizing center organizationGO:003102310.012
organism emergence from protective structureGO:007168440.012
negative regulation of intracellular transportGO:003238730.012
response to amphetamineGO:000197510.012
recombinational repairGO:000072510.012
cellular response to hypoxiaGO:007145610.011
synaptic growth at neuromuscular junctionGO:005112420.011
phosphorylationGO:0016310690.011
lateral inhibitionGO:004633110.011
regulation of response to stimulusGO:00485832690.011
Human
negative regulation of signal transductionGO:0009968940.011
regulation of cellular protein metabolic processGO:0032268520.011
regulation of chromatin modificationGO:190330850.011
multi organism reproductive processGO:0044703360.011
regulation of protein transportGO:005122330.011
response to drugGO:004249330.011
response to glucocorticoidGO:005138410.011
anterior posterior pattern specificationGO:00099521520.011
purine ribonucleotide metabolic processGO:0009150270.010
regulation of anatomical structure morphogenesisGO:00226031300.010
immunoglobulin mediated immune responseGO:001606430.010
negative regulation of cellular catabolic processGO:003133030.010
dna templated transcription elongationGO:000635430.010
regulation of cell cycle processGO:0010564200.010
tissue regenerationGO:0042246740.010
guanosine containing compound metabolic processGO:190106840.010
regulation of glial cell differentiationGO:004568540.010
regulation of transcription elongation from rna polymerase ii promoterGO:003424330.010
cellular response to external stimulusGO:007149620.010
cell surface receptor signaling pathwayGO:00071663250.010

apex1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.036
disease of cellular proliferationDOID:1456600.036
organ system cancerDOID:005068600.035
disease of metabolismDOID:001466700.025
nervous system diseaseDOID:86300.015
sensory system diseaseDOID:005015500.015
disease of anatomical entityDOID:700.015