Danio rerio

0 known processes

apex2

APEX nuclease (apurinic/apyrimidinic endonuclease) 2

(Aliases: MGC55889,zgc:55889)

apex2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
reflexGO:006000420.150
regulation of cell shapeGO:000836010.122
vascular endothelial growth factor receptor signaling pathwayGO:0048010130.121
sensory perception of chemical stimulusGO:000760630.089
regulation of multicellular organism growthGO:004001440.083
single organism organelle organizationGO:19025891990.070
signal transductionGO:00071654550.066
neural precursor cell proliferationGO:0061351200.066
regulation of protein targetingGO:190353320.064
response to nutrientGO:000758430.064
agingGO:000756820.063
larval developmentGO:000216420.058
neuroblast proliferationGO:000740520.054
multicellular organism growthGO:003526440.054
regulation of response to stimulusGO:00485832690.052
growthGO:00400071740.050
cell morphogenesisGO:00009022890.050
maintenance of locationGO:005123540.049
regulation of cellular metabolic processGO:00313233200.047
histone phosphorylationGO:001657220.047
stem cell divisionGO:001714510.045
regulation of protein transportGO:005122330.044
organelle organizationGO:00069962270.044
digestive tract developmentGO:00485652650.044
enzyme linked receptor protein signaling pathwayGO:00071671060.044
regulation of synapse organizationGO:005080730.042
response to carbohydrateGO:000974330.042
ubiquitin dependent protein catabolic processGO:000651130.042
chemosensory behaviorGO:000763510.042
negative regulation of response to stimulusGO:00485851040.041
positive regulation of purine nucleotide catabolic processGO:003312310.041
heart developmentGO:00075073130.041
regulation of nucleotide catabolic processGO:003081120.040
cellular component morphogenesisGO:00329893360.040
regulation of gene expressionGO:00104682650.039
phagocytosisGO:000690930.038
morphogenesis of an epitheliumGO:00020093330.038
establishment of protein localization to organelleGO:007259440.037
tube morphogenesisGO:00352393490.036
response to chemicalGO:00422213200.036
digestive system developmentGO:00551232890.036
spindle assemblyGO:005122520.035
angiogenesisGO:00015251580.035
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.035
regulation of protein localization to nucleusGO:190018020.035
stem cell proliferationGO:007208940.035
meiotic cell cycle processGO:190304630.035
localization of cellGO:00516742440.034
regulation of primary metabolic processGO:00800903110.034
regulation of cytoplasmic transportGO:190364940.034
phosphate containing compound metabolic processGO:00067961080.033
peptidyl serine phosphorylationGO:001810510.033
regulation of purine nucleotide catabolic processGO:003312120.033
nucleocytoplasmic transportGO:000691340.033
positive regulation of cellular catabolic processGO:003133130.033
guanosine containing compound catabolic processGO:190106920.032
meiosis iGO:000712710.032
cellular aromatic compound metabolic processGO:00067252950.031
gtp catabolic processGO:000618420.031
regulation of signal transductionGO:00099662250.031
macromolecular complex subunit organizationGO:0043933740.031
digestive tract morphogenesisGO:00485462310.031
cytoskeleton dependent cytokinesisGO:006164030.030
cellular response to biotic stimulusGO:007121630.030
positive regulation of transportGO:005105020.030
centrosome organizationGO:005129710.030
regulation of establishment of protein localizationGO:007020140.030
blood vessel morphogenesisGO:00485142160.030
heterocycle metabolic processGO:00464832900.029
regulation of protein import into nucleusGO:004230620.029
nitrogen compound metabolic processGO:00068073190.029
cytokinetic processGO:003250620.029
single organism localizationGO:19025782250.029
regulation of organelle assemblyGO:190211540.029
positive regulation of catabolic processGO:000989640.029
regulation of nucleocytoplasmic transportGO:004682220.029
chromosome organization involved in meiosisGO:007019210.028
generation of neuronsGO:00486993850.028
phosphorus metabolic processGO:00067931090.028
centrosome cycleGO:000709810.028
regulation of rho protein signal transductionGO:003502320.027
regulation of nitrogen compound metabolic processGO:00511712510.027
microtubule organizing center organizationGO:003102310.027
nuclear importGO:005117030.027
modification dependent macromolecule catabolic processGO:004363230.027
cellular component movementGO:00069283350.027
cytoskeleton organizationGO:0007010960.026
cell motilityGO:00488702440.026
regulation of intracellular protein transportGO:003315730.026
regulation of gtp catabolic processGO:003312420.026
cell migration involved in gastrulationGO:0042074790.026
regulation of nucleoside metabolic processGO:000911820.025
protein localization to microtubule cytoskeletonGO:007269810.025
regulation of biological qualityGO:00650082630.025
response to hydrogen peroxideGO:004254230.025
embryonic organ developmentGO:00485683810.025
single organism metabolic processGO:00447102170.025
positive regulation of muscle cell differentiationGO:005114910.025
meiotic nuclear divisionGO:000712640.025
biosynthetic processGO:00090582940.025
proteolysis involved in cellular protein catabolic processGO:005160330.025
regulation of bindingGO:005109830.024
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.024
nucleobase containing compound metabolic processGO:00061392740.024
regulation of dna templated transcription in response to stressGO:004362000.024
transportGO:00068102200.024
response to glucoseGO:000974930.024
vasculature developmentGO:00019442780.024
regulation of mrna splicing via spliceosomeGO:004802430.024
actin filament polymerizationGO:003004120.024
gtp metabolic processGO:004603940.024
regulation of i kappab kinase nf kappab signalingGO:004312240.023
synaptic growth at neuromuscular junctionGO:005112420.023
response to stressGO:00069502630.023
positive regulation of cell cycleGO:004578730.023
establishment of localizationGO:00512342440.023
gene expressionGO:00104672520.023
protein polymerizationGO:005125840.023
protein importGO:001703830.022
response to hexoseGO:000974630.022
response to external stimulusGO:00096052640.022
protein metabolic processGO:00195381830.022
cellular protein catabolic processGO:004425740.022
organic cyclic compound metabolic processGO:19013603010.022
regulation of macromolecule metabolic processGO:00602553170.022
negative regulation of cytoplasmic transportGO:190365020.022
cellular carbohydrate metabolic processGO:004426240.022
regulation of metabolic processGO:00192223590.022
regulation of developmental processGO:00507932470.022
mitotic dna integrity checkpointGO:004477440.022
i kappab kinase nf kappab signalingGO:000724940.022
regulation of dna replicationGO:000627530.022
nucleic acid metabolic processGO:00903042440.022
extrinsic apoptotic signaling pathwayGO:009719130.021
regulation of mrna processingGO:005068430.021
cell part morphogenesisGO:00329902460.021
lipid storageGO:001991510.021
sequestering of metal ionGO:005123830.021
cellular response to lipopolysaccharideGO:007122230.021
positive regulation of cellular component biogenesisGO:004408930.021
cellular response to external stimulusGO:007149620.021
nuclear transportGO:005116940.021
cellular nitrogen compound metabolic processGO:00346412900.021
protein import into nucleusGO:000660630.021
positive regulation of nitrogen compound metabolic processGO:0051173690.020
heart processGO:0003015710.020
ameboidal type cell migrationGO:00016671430.020
axon extensionGO:0048675450.020
protein localization to nucleusGO:003450430.020
proteasomal protein catabolic processGO:001049820.020
response to monosaccharideGO:003428430.020
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.019
single organism membrane fusionGO:004480120.019
positive regulation of nucleoside metabolic processGO:004597910.019
heart morphogenesisGO:00030071560.019
atp catabolic processGO:000620040.019
positive regulation of gtp catabolic processGO:003312610.019
regulation of macromolecule biosynthetic processGO:00105562250.019
lipid oxidationGO:003444010.019
single organism nuclear importGO:190259330.019
cell projection morphogenesisGO:00488582440.019
alternative mrna splicing via spliceosomeGO:000038010.019
cellular response to radiationGO:007147840.019
blood vessel developmentGO:00015682460.019
spindle assembly involved in mitosisGO:009030710.019
regulation of signalingGO:00230512350.019
cellular response to reactive oxygen speciesGO:003461420.019
cytokinesisGO:000091030.019
hepaticobiliary system developmentGO:0061008980.019
mitotic nuclear divisionGO:0007067180.019
modification dependent protein catabolic processGO:001994130.018
cellular response to extracellular stimulusGO:003166820.018
negative regulation of mapk cascadeGO:004340940.018
cellular component disassemblyGO:002241110.018
regulation of synapse assemblyGO:005196330.018
sensory perception of touchGO:005097520.018
macromolecule modificationGO:00434121110.018
amine metabolic processGO:000930820.018
actin polymerization or depolymerizationGO:000815420.018
positive regulation of myeloid cell differentiationGO:004563920.018
response to biotic stimulusGO:0009607970.018
regulation of gtpase activityGO:004308720.018
developmental growthGO:00485891660.018
heterocycle biosynthetic processGO:00181302150.018
cellular component assemblyGO:00226071700.018
protein acylationGO:004354330.018
regulation of cellular macromolecule biosynthetic processGO:20001122220.017
protein targeting to nucleusGO:004474430.017
fatty acid oxidationGO:001939510.017
small molecule metabolic processGO:0044281770.017
negative regulation of synapse assemblyGO:005196420.017
cellular amine metabolic processGO:004410620.017
female meiotic divisionGO:000714320.017
regulation of nucleic acid templated transcriptionGO:19035062130.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.017
positive regulation of nucleotide catabolic processGO:003081310.017
purine nucleoside monophosphate catabolic processGO:000912840.017
macromolecular complex disassemblyGO:003298410.017
mitochondrion organizationGO:000700540.017
oxoacid metabolic processGO:0043436310.017
spermatid developmentGO:000728620.017
cell migrationGO:00164772370.017
cell aggregationGO:009874330.017
regulation of bmp signaling pathwayGO:0030510390.017
regulation of alternative mrna splicing via spliceosomeGO:000038110.017
regulation of multicellular organismal processGO:00512392770.017
mitotic cell cycle processGO:1903047480.017
negative regulation of apoptotic processGO:0043066550.017
cell surface receptor signaling pathwayGO:00071663250.017
regulation of anatomical structure morphogenesisGO:00226031300.016
membrane fusionGO:006102520.016
regulation of cell cycleGO:0051726520.016
organonitrogen compound metabolic processGO:1901564740.016
cell cycleGO:0007049930.016
microtubule cytoskeleton organization involved in mitosisGO:190285010.016
positive regulation of gtpase activityGO:004354710.016
purine ribonucleoside monophosphate catabolic processGO:000916940.016
circulatory system processGO:0003013870.016
system processGO:00030081850.016
actin filament organizationGO:0007015150.016
regulation of biosynthetic processGO:00098892500.016
negative regulation of cell deathGO:0060548600.016
neuron differentiationGO:00301823530.016
convergent extensionGO:00600261180.016
specification of symmetryGO:00097992040.016
regulation of cellular amine metabolic processGO:003323800.016
deathGO:00162651210.016
nucleoside monophosphate catabolic processGO:000912540.015
cell adhesionGO:0007155400.015
apoptotic processGO:00069151160.015
neuron projection morphogenesisGO:00488121610.015
response to growth factorGO:0070848390.015
protein acetylationGO:000647320.015
guanosine containing compound metabolic processGO:190106840.015
negative regulation of cellular processGO:00485232830.015
actin cytoskeleton organizationGO:0030036630.015
regulation of protein bindingGO:004339330.015
secondary metabolic processGO:001974830.015
rna metabolic processGO:00160702190.014
organelle fusionGO:004828430.014
regulation of phosphorus metabolic processGO:0051174430.014
g2 dna damage checkpointGO:003157230.014
primary neural tube formationGO:001402010.014
peptidyl lysine acetylationGO:001839420.014
negative regulation of i kappab kinase nf kappab signalingGO:004312410.014
negative regulation of nuclear divisionGO:005178430.014
gastrulation with mouth forming secondGO:0001702440.014
regulation of cellular ketone metabolic processGO:001056570.014
gastrulationGO:00073692080.014
mesodermal cell differentiationGO:0048333210.014
regulation of reproductive processGO:200024140.014
regulation of erk1 and erk2 cascadeGO:007037240.014
positive regulation of dna metabolic processGO:005105410.014
organic substance biosynthetic processGO:19015762890.014
regulation of cellular biosynthetic processGO:00313262450.014
cellular response to nutrient levelsGO:003166920.014
regulation of extrinsic apoptotic signaling pathwayGO:200123630.014
retina development in camera type eyeGO:00600411460.014
cell fate commitmentGO:0045165990.014
regulation of meiotic cell cycleGO:005144510.014
cellular macromolecule biosynthetic processGO:00346452240.014
phagocytosis engulfmentGO:000691110.014
locomotionGO:00400113130.014
cellular macromolecule metabolic processGO:00442603910.014
cell agingGO:000756920.014
regulation of syncytium formation by plasma membrane fusionGO:006014220.014
cellular biosynthetic processGO:00442492860.014
regulation of microtubule cytoskeleton organizationGO:007050730.014
endosomal transportGO:001619720.013
regulation of cytokine productionGO:000181730.013
organelle localizationGO:0051640490.013
regulation of programmed cell deathGO:00430671010.013
regulation of protein complex assemblyGO:004325430.013
cilium morphogenesisGO:0060271850.013
regulation of protein complex disassemblyGO:004324410.013
protein complex subunit organizationGO:0071822460.013
peptide transportGO:001583310.013
biological adhesionGO:0022610400.013
regulation of cell communicationGO:00106462320.013
membrane invaginationGO:001032410.013
regulation of dendrite developmentGO:005077330.013
protein secretionGO:000930610.013
organic acid metabolic processGO:0006082310.013
defense response to fungusGO:005083220.013
protein complex disassemblyGO:004324110.013
golgi vesicle transportGO:004819330.013
negative regulation of protein phosphorylationGO:000193340.013
negative regulation of programmed cell deathGO:0043069580.013
regulation of transcription from rna polymerase ii promoterGO:00063571140.013
regulation of rna metabolic processGO:00512522240.013
mitotic g2 dna damage checkpointGO:000709530.013
positive regulation of cellular processGO:00485222010.013
cell projection organizationGO:00300302840.013
regulation of oocyte developmentGO:006028130.013
protein localization to plasma membraneGO:007265910.013
chromosome organizationGO:0051276310.013
antimicrobial humoral responseGO:001973020.013
cell substrate adhesionGO:003158940.013
mesoderm morphogenesisGO:0048332510.013
translational initiationGO:000641330.012
cellular respirationGO:004533330.012
meiotic chromosome segregationGO:004513230.012
cellular amide metabolic processGO:004360340.012
actin filament based processGO:0030029640.012
cognitionGO:005089010.012
immune system processGO:00023762410.012
positive regulation of i kappab kinase nf kappab signalingGO:004312330.012
positive regulation of canonical wnt signaling pathwayGO:009026340.012
regulation of cell activationGO:005086510.012
negative regulation of cell communicationGO:0010648960.012
positive regulation of developmental processGO:0051094500.012
regulation of developmental growthGO:0048638380.012
tube closureGO:006060610.012
cellular localizationGO:0051641970.012
positive regulation of biological processGO:00485182530.012
meiotic spindle organizationGO:000021210.012
behaviorGO:0007610740.012
regulation of cell morphogenesisGO:0022604420.012
response to inorganic substanceGO:0010035380.012
regulation of nucleobase containing compound metabolic processGO:00192192500.012
cellular response to organic substanceGO:00713101050.012
negative regulation of stress activated mapk cascadeGO:003287310.012
nuclear divisionGO:0000280230.012
mitotic g2 m transition checkpointGO:004481830.012
cation homeostasisGO:0055080330.012
osteoclast differentiationGO:003031610.012
positive regulation of protein complex assemblyGO:003133420.012
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.012
peptidyl serine modificationGO:001820920.012
g1 s transition of mitotic cell cycleGO:000008210.012
hormone transportGO:000991420.012
negative regulation of immune responseGO:005077720.012
cell cycle processGO:0022402530.011
mitotic cell cycle embryonicGO:004544820.011
sprouting angiogenesisGO:0002040530.011
phosphorylationGO:0016310690.011
regulation of synaptic growth at neuromuscular junctionGO:000858210.011
cell matrix adhesionGO:000716040.011
transcription from rna polymerase ii promoterGO:0006366800.011
tissue remodelingGO:004877140.011
cellular response to endogenous stimulusGO:0071495680.011
ribonucleoside monophosphate catabolic processGO:000915840.011
negative regulation of sequestering of calcium ionGO:005128340.011
positive regulation of cellular amine metabolic processGO:003324000.011
protein polyubiquitinationGO:000020940.011
dna catabolic processGO:000630810.011
nucleobase containing compound biosynthetic processGO:00346542050.011
peptidyl threonine modificationGO:001821010.011
developmental growth involved in morphogenesisGO:0060560860.011
negative regulation of translationGO:001714810.011
positive regulation of multi organism processGO:004390230.011
thermosensory behaviorGO:004004010.011
dorsal ventral pattern formationGO:00099531250.011
organic cyclic compound biosynthetic processGO:19013622230.011
cellular amino acid metabolic processGO:000652070.011
regulation of cell substrate adhesionGO:001081010.011
negative regulation of mitosisGO:004583930.011
embryonic heart tube developmentGO:00350501330.011
intracellular signal transductionGO:0035556850.011
cellular nitrogen compound biosynthetic processGO:00442712180.011
adult behaviorGO:003053420.011
mitotic dna damage checkpointGO:004477340.011
positive regulation of cell adhesionGO:004578510.011
regulation of reactive oxygen species metabolic processGO:200037720.011
negative regulation of multi organism processGO:004390130.011
protein depolymerizationGO:005126110.011
regulation of cellular amino acid metabolic processGO:000652100.011
cellular transition metal ion homeostasisGO:004691630.011
regulation of ras gtpase activityGO:003231820.011
regulation of inflammatory responseGO:005072720.011
cell cycle g1 s phase transitionGO:004484310.011
regulation of production of molecular mediator of immune responseGO:000270010.011
hematopoietic or lymphoid organ developmentGO:00485341910.011
negative regulation of protein transportGO:005122430.011
hormone secretionGO:004687920.011
regulation of multicellular organismal developmentGO:20000262230.011
regulation of phosphate metabolic processGO:0019220430.011
positive regulation of ras gtpase activityGO:003232010.011
positive regulation of secretion by cellGO:190353210.011
regulation of localizationGO:00328791040.011
nuclear exportGO:005116810.011
nucleic acid templated transcriptionGO:00976591810.010
negative regulation of jnk cascadeGO:004632910.010
small gtpase mediated signal transductionGO:000726480.010
organism emergence from protective structureGO:007168440.010
mitotic cell cycleGO:0000278640.010
single organism cellular localizationGO:1902580460.010
positive regulation of epithelial cell proliferationGO:005067910.010
histone modificationGO:0016570200.010
negative regulation of defense responseGO:003134820.010
response to ionizing radiationGO:001021260.010
cartilage condensationGO:000150230.010
cellular response to starvationGO:000926710.010
positive regulation of cytokine productionGO:000181920.010
spermatid differentiationGO:004851520.010
negative regulation of intracellular transportGO:003238730.010
response to organic substanceGO:00100331530.010
cell cycle arrestGO:000705010.010
sequestering of calcium ionGO:005120830.010
erythrocyte differentiationGO:0030218540.010
response to bacteriumGO:0009617580.010
morphogenesis of an epithelial sheetGO:0002011490.010
ovulation cycleGO:004269820.010
release of sequestered calcium ion into cytosolGO:005120930.010
macromolecule biosynthetic processGO:00090592270.010

apex2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.019
disease of cellular proliferationDOID:1456600.017
disease of metabolismDOID:001466700.014
inherited metabolic disorderDOID:65500.014
lysosomal storage diseaseDOID:321100.014
nervous system diseaseDOID:86300.013
cancerDOID:16200.012
organ system cancerDOID:005068600.011