IMP: Integrative Multi-species Prediction

Danio rerio

31 known processes

runx3

runt-related transcription factor 3

(Aliases: runxb)

Ensembl: ENSDARG00000052826
ZFIN: ZDB-GENE-000605-2
Entrez: 58127
UniProtKB: Q9DEA0

Process Predictions
Disease Predictions

runx3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
central nervous system development	GO:0007417	387	0.869
cellular biosynthetic process	GO:0044249	286	0.838	Zebrafish Mouse
regulation of cellular biosynthetic process	GO:0031326	245	0.775	Zebrafish Mouse
nitrogen compound metabolic process	GO:0006807	319	0.742	Zebrafish Mouse
response to bacterium	GO:0009617	58	0.727
negative regulation of biological process	GO:0048519	304	0.690	Mouse
regulation of primary metabolic process	GO:0080090	311	0.689	Zebrafish Mouse
neuromuscular synaptic transmission	GO:0007274	2	0.623
signal transduction	GO:0007165	455	0.615	Mouse
cell surface receptor signaling pathway	GO:0007166	325	0.602	Mouse
cellular aromatic compound metabolic process	GO:0006725	295	0.590	Zebrafish Mouse
regulation of nitrogen compound metabolic process	GO:0051171	251	0.584	Zebrafish Mouse
regulation of multicellular organismal process	GO:0051239	277	0.564
camera type eye development	GO:0043010	222	0.558
establishment of localization	GO:0051234	244	0.555
cartilage development	GO:0051216	96	0.521
digestive system development	GO:0055123	289	0.516
cellular component movement	GO:0006928	335	0.511	Mouse
neuron development	GO:0048666	262	0.506	Mouse
nucleobase containing compound biosynthetic process	GO:0034654	205	0.502	Zebrafish Mouse
hematopoietic or lymphoid organ development	GO:0048534	191	0.482
skeletal system morphogenesis	GO:0048705	102	0.463
ameboidal type cell migration	GO:0001667	143	0.450
skeletal system development	GO:0001501	181	0.415
kidney development	GO:0001822	92	0.410
vasculature development	GO:0001944	278	0.403
cellular nitrogen compound metabolic process	GO:0034641	290	0.399	Zebrafish Mouse
heterocycle metabolic process	GO:0046483	290	0.389	Zebrafish Mouse
organic cyclic compound metabolic process	GO:1901360	301	0.389	Zebrafish Mouse
sympathetic nervous system development	GO:0048485	3	0.379
connective tissue development	GO:0061448	99	0.371
immune system development	GO:0002520	191	0.364
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.361	Zebrafish Mouse
regulation of signaling	GO:0023051	235	0.343	Mouse
regulation of nucleic acid templated transcription	GO:1903506	213	0.327	Zebrafish Mouse
chordate embryonic development	GO:0043009	271	0.326
lamellipodium organization	GO:0097581	1	0.323
regulation of rna metabolic process	GO:0051252	224	0.323	Zebrafish Mouse
cell morphogenesis involved in differentiation	GO:0000904	195	0.318	Mouse
single organism localization	GO:1902578	225	0.318
lymphocyte differentiation	GO:0030098	9	0.317
axonogenesis	GO:0007409	152	0.313	Mouse
regulation of signal transduction	GO:0009966	225	0.312	Mouse
regulation of gene expression	GO:0010468	265	0.312	Zebrafish Mouse
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.310
eye development	GO:0001654	277	0.302
regulation of transcription dna templated	GO:0006355	213	0.300	Zebrafish Mouse
axon development	GO:0061564	166	0.295	Mouse
response to external stimulus	GO:0009605	264	0.288	Mouse
developmental growth involved in morphogenesis	GO:0060560	86	0.287
positive regulation of response to stimulus	GO:0048584	80	0.285	Mouse
cell motility	GO:0048870	244	0.271
cartilage development involved in endochondral bone morphogenesis	GO:0060351	8	0.270
positive regulation of gene expression	GO:0010628	71	0.267	Zebrafish
regulation of biosynthetic process	GO:0009889	250	0.266	Zebrafish Mouse
embryonic organ morphogenesis	GO:0048562	274	0.263
embryonic camera type eye development	GO:0031076	29	0.262
hemopoiesis	GO:0030097	183	0.261
regulation of macromolecule metabolic process	GO:0060255	317	0.257	Zebrafish Mouse
epidermal cell differentiation	GO:0009913	36	0.256
determination of left right symmetry	GO:0007368	179	0.254
tube morphogenesis	GO:0035239	349	0.238
dorsal ventral pattern formation	GO:0009953	125	0.235	Zebrafish
homeostasis of number of cells	GO:0048872	62	0.233
gene expression	GO:0010467	252	0.231	Zebrafish Mouse
embryonic camera type eye formation	GO:0060900	10	0.227
motor neuron axon guidance	GO:0008045	23	0.225
embryonic camera type eye morphogenesis	GO:0048596	19	0.224
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.219	Mouse
positive regulation of signal transduction	GO:0009967	56	0.215	Mouse
renal system development	GO:0072001	94	0.212
blood vessel morphogenesis	GO:0048514	216	0.208
regulation of cellular metabolic process	GO:0031323	320	0.207	Zebrafish Mouse
organic substance biosynthetic process	GO:1901576	289	0.205	Zebrafish Mouse
odontogenesis of dentin containing tooth	GO:0042475	1	0.199
t cell differentiation	GO:0030217	6	0.198
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.198	Zebrafish Mouse
muscle structure development	GO:0061061	196	0.192
single organism transport	GO:0044765	206	0.189
nucleobase containing compound metabolic process	GO:0006139	274	0.186	Zebrafish Mouse
cellular macromolecule metabolic process	GO:0044260	391	0.183	Human Zebrafish Mouse
gland development	GO:0048732	143	0.181
phagocytosis	GO:0006909	3	0.178
amine metabolic process	GO:0009308	2	0.177
lymph vessel development	GO:0001945	27	0.174
rna metabolic process	GO:0016070	219	0.174	Zebrafish Mouse
specification of symmetry	GO:0009799	204	0.173
ectodermal placode development	GO:0071696	37	0.170
regulation of localization	GO:0032879	104	0.169
regulation of cell communication	GO:0010646	232	0.168	Mouse
actin filament based process	GO:0030029	64	0.166
morphogenesis of an epithelial sheet	GO:0002011	49	0.165
neuron differentiation	GO:0030182	353	0.164	Mouse
heart looping	GO:0001947	94	0.163
transport	GO:0006810	220	0.162
organic acid metabolic process	GO:0006082	31	0.160
regulation of wound healing	GO:0061041	2	0.158
embryonic organ development	GO:0048568	381	0.157
otic vesicle morphogenesis	GO:0071600	34	0.157
embryonic skeletal system development	GO:0048706	97	0.157
neural crest cell development	GO:0014032	62	0.156
skin development	GO:0043588	54	0.153	Mouse
retina development in camera type eye	GO:0060041	146	0.152
cellular response to external stimulus	GO:0071496	2	0.151
small molecule metabolic process	GO:0044281	77	0.150
cell migration	GO:0016477	237	0.150
cellular response to growth factor stimulus	GO:0071363	39	0.150
transcription dna templated	GO:0006351	181	0.147	Zebrafish Mouse
rna biosynthetic process	GO:0032774	181	0.145	Zebrafish Mouse
heterocycle biosynthetic process	GO:0018130	215	0.145	Zebrafish Mouse
positive regulation of cellular process	GO:0048522	201	0.142	Zebrafish Mouse
regulation of cell projection assembly	GO:0060491	4	0.139
neural tube development	GO:0021915	62	0.136
generation of neurons	GO:0048699	385	0.136	Mouse
regulation of developmental process	GO:0050793	247	0.135
brain development	GO:0007420	293	0.135
locomotion	GO:0040011	313	0.134	Mouse
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.133	Zebrafish Mouse
sensory organ morphogenesis	GO:0090596	200	0.131
positive regulation of metabolic process	GO:0009893	108	0.125	Zebrafish
regulation of macromolecule biosynthetic process	GO:0010556	225	0.125	Zebrafish Mouse
ectodermal placode morphogenesis	GO:0071697	32	0.124
positive regulation of notch signaling pathway	GO:0045747	3	0.124
nucleic acid templated transcription	GO:0097659	181	0.124	Zebrafish Mouse
cell projection assembly	GO:0030031	64	0.123
development of primary female sexual characteristics	GO:0046545	4	0.123
regulation of anatomical structure morphogenesis	GO:0022603	130	0.122
organonitrogen compound metabolic process	GO:1901564	74	0.121
regulation of embryonic development	GO:0045995	47	0.118
camera type eye morphogenesis	GO:0048593	108	0.117
negative regulation of cellular process	GO:0048523	283	0.117	Mouse
t cell activation	GO:0042110	6	0.116
female sex differentiation	GO:0046660	4	0.115
morphogenesis of an epithelium	GO:0002009	333	0.115	Mouse
positive regulation of transcription dna templated	GO:0045893	57	0.114	Zebrafish
cellular macromolecule biosynthetic process	GO:0034645	224	0.113	Zebrafish Mouse
regulation of response to stimulus	GO:0048583	269	0.109	Mouse
gastrulation	GO:0007369	208	0.108
positive regulation of transport	GO:0051050	2	0.107
response to chemical	GO:0042221	320	0.107	Mouse
peripheral nervous system neuron differentiation	GO:0048934	28	0.105
positive regulation of biosynthetic process	GO:0009891	68	0.105	Zebrafish
oxoacid metabolic process	GO:0043436	31	0.104
positive regulation of cellular component biogenesis	GO:0044089	3	0.102
rostrocaudal neural tube patterning	GO:0021903	29	0.102
defense response to bacterium	GO:0042742	22	0.101
single organism cellular localization	GO:1902580	46	0.101
response to growth factor	GO:0070848	39	0.100
otolith development	GO:0048840	32	0.099
biosynthetic process	GO:0009058	294	0.099	Zebrafish Mouse
cellular amine metabolic process	GO:0044106	2	0.099
cellular amino acid metabolic process	GO:0006520	7	0.098
epidermis development	GO:0008544	48	0.094	Mouse
positive regulation of cellular metabolic process	GO:0031325	94	0.094	Zebrafish
digestive tract morphogenesis	GO:0048546	231	0.093
neural tube patterning	GO:0021532	33	0.091
determination of bilateral symmetry	GO:0009855	204	0.089
convergent extension	GO:0060026	118	0.088
thyroid gland development	GO:0030878	12	0.088
angiogenesis	GO:0001525	158	0.088
heart jogging	GO:0003146	40	0.087
regulation of cellular amine metabolic process	GO:0033238	0	0.087
catecholamine biosynthetic process	GO:0042423	2	0.086
immune effector process	GO:0002252	23	0.086
peripheral nervous system neuron development	GO:0048935	22	0.086
regionalization	GO:0003002	274	0.086	Zebrafish
regulation of cell shape	GO:0008360	1	0.085
ossification	GO:0001503	23	0.084
cell activation	GO:0001775	16	0.084
larval development	GO:0002164	2	0.084
growth plate cartilage development	GO:0003417	2	0.083
cellular response to chemical stimulus	GO:0070887	157	0.083
cellular component morphogenesis	GO:0032989	336	0.083	Mouse
defense response to other organism	GO:0098542	33	0.082
positive regulation of macromolecule metabolic process	GO:0010604	93	0.082	Zebrafish
response to radiation	GO:0009314	51	0.082
regulation of protein complex assembly	GO:0043254	3	0.082
regulation of cellular ketone metabolic process	GO:0010565	7	0.081
determination of dorsal ventral asymmetry	GO:0048262	34	0.079
single organism intracellular transport	GO:1902582	25	0.078
midbrain hindbrain boundary development	GO:0030917	23	0.078
otic vesicle formation	GO:0030916	27	0.078
regulation of metabolic process	GO:0019222	359	0.078	Zebrafish Mouse
localization of cell	GO:0051674	244	0.077
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.077
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.077
cellular ketone metabolic process	GO:0042180	11	0.077
regulation of axonogenesis	GO:0050770	32	0.077
establishment of localization in cell	GO:0051649	77	0.077
regulation of stem cell differentiation	GO:2000736	4	0.076
epithelial cell differentiation	GO:0030855	116	0.075
cell proliferation	GO:0008283	80	0.075	Mouse
b cell differentiation	GO:0030183	1	0.075
response to biotic stimulus	GO:0009607	97	0.074
thymus development	GO:0048538	10	0.074
embryonic skeletal system morphogenesis	GO:0048704	93	0.074
organic cyclic compound biosynthetic process	GO:1901362	223	0.073	Zebrafish Mouse
positive regulation of cellular amine metabolic process	GO:0033240	0	0.072
pancreas development	GO:0031016	84	0.071
aromatic compound biosynthetic process	GO:0019438	217	0.071	Zebrafish Mouse
cell cycle	GO:0007049	93	0.071	Mouse
peripheral nervous system development	GO:0007422	55	0.070
regulation of cell activation	GO:0050865	1	0.070
stem cell proliferation	GO:0072089	4	0.069
retina morphogenesis in camera type eye	GO:0060042	79	0.069
detection of chemical stimulus involved in sensory perception	GO:0050907	3	0.069
intracellular signal transduction	GO:0035556	85	0.068
morphogenesis of a branching epithelium	GO:0061138	16	0.067
regulation of biomineral tissue development	GO:0070167	2	0.067
mesenchymal cell proliferation	GO:0010463	1	0.067
positive regulation of signaling	GO:0023056	56	0.066	Mouse
multicellular organism growth	GO:0035264	4	0.066
endochondral bone morphogenesis	GO:0060350	8	0.066
optic placode formation involved in camera type eye formation	GO:0046619	3	0.066
regulation of cellular amino acid metabolic process	GO:0006521	0	0.066
endochondral bone growth	GO:0003416	2	0.066
urogenital system development	GO:0001655	97	0.065
embryo development ending in birth or egg hatching	GO:0009792	271	0.065
digestive tract development	GO:0048565	265	0.065
autonomic nervous system development	GO:0048483	19	0.065
epithelial cell morphogenesis	GO:0003382	2	0.064
b cell activation	GO:0042113	2	0.064
sensory organ development	GO:0007423	393	0.064
regulation of apoptotic process	GO:0042981	98	0.063	Mouse
vestibular receptor cell development	GO:0060118	3	0.063
immune system process	GO:0002376	241	0.062
positive regulation of cellular biosynthetic process	GO:0031328	68	0.062	Zebrafish
embryonic heart tube development	GO:0035050	133	0.062
macromolecule biosynthetic process	GO:0009059	227	0.062	Zebrafish Mouse
carboxylic acid metabolic process	GO:0019752	22	0.061
single organism metabolic process	GO:0044710	217	0.060
regulation of tyrosine phosphorylation of stat protein	GO:0042509	1	0.060
neuron projection extension	GO:1990138	45	0.059
morphogenesis of a branching structure	GO:0001763	21	0.058
endoderm development	GO:0007492	49	0.058
actin filament bundle organization	GO:0061572	6	0.058
epiboly involved in gastrulation with mouth forming second	GO:0055113	35	0.057
regulation of rna biosynthetic process	GO:2001141	213	0.057	Zebrafish Mouse
cellular response to organic substance	GO:0071310	105	0.056
positive regulation of map kinase activity	GO:0043406	3	0.056
mesenchymal cell differentiation	GO:0048762	87	0.056
regulation of multicellular organismal development	GO:2000026	223	0.055
cilium assembly	GO:0042384	58	0.055
cell death	GO:0008219	121	0.055	Mouse
secondary metabolic process	GO:0019748	3	0.055
developmental cell growth	GO:0048588	52	0.055
nephron morphogenesis	GO:0072028	2	0.055
nephron development	GO:0072006	31	0.054
positive regulation of biological process	GO:0048518	253	0.054	Zebrafish Mouse
positive regulation of neuron apoptotic process	GO:0043525	1	0.053
cell differentiation in spinal cord	GO:0021515	40	0.053
myeloid leukocyte migration	GO:0097529	12	0.053
regulation of cell differentiation	GO:0045595	142	0.053
cell projection organization	GO:0030030	284	0.052	Mouse
segmentation	GO:0035282	97	0.052
response to other organism	GO:0051707	97	0.052
hair cell differentiation	GO:0035315	32	0.050
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.050
ovulation cycle	GO:0042698	2	0.049
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.048	Mouse
inner ear receptor cell fate commitment	GO:0060120	4	0.048
positive regulation of protein polymerization	GO:0032273	2	0.048
cell morphogenesis	GO:0000902	289	0.048	Mouse
nephron epithelium morphogenesis	GO:0072088	1	0.047
mesenchyme development	GO:0060485	127	0.047
positive regulation of protein complex assembly	GO:0031334	2	0.047
kidney vasculature development	GO:0061440	2	0.047
negative regulation of stem cell differentiation	GO:2000737	2	0.047
muscle cell differentiation	GO:0042692	139	0.047
regulation of establishment or maintenance of cell polarity	GO:0032878	2	0.046
endodermal cell differentiation	GO:0035987	19	0.046
carbohydrate derivative metabolic process	GO:1901135	61	0.046
protein complex subunit organization	GO:0071822	46	0.046
synaptic growth at neuromuscular junction	GO:0051124	2	0.046
lymphocyte activation	GO:0046649	10	0.045
blood vessel development	GO:0001568	246	0.044
bone development	GO:0060348	14	0.043
myeloid cell homeostasis	GO:0002262	56	0.043
embryonic eye morphogenesis	GO:0048048	30	0.043
defense response	GO:0006952	47	0.043
female gonad development	GO:0008585	4	0.043
trigeminal nerve development	GO:0021559	3	0.043
cellular component assembly involved in morphogenesis	GO:0010927	107	0.043
renal tubule morphogenesis	GO:0061333	1	0.042
negative regulation of multicellular organismal process	GO:0051241	69	0.042
positive regulation of secretion	GO:0051047	1	0.042
spinal cord development	GO:0021510	46	0.042
nucleic acid metabolic process	GO:0090304	244	0.041	Zebrafish Mouse
regulation of phosphate metabolic process	GO:0019220	43	0.041
phosphorus metabolic process	GO:0006793	109	0.041	Human
positive regulation of programmed cell death	GO:0043068	29	0.041	Mouse
regulation of cell proliferation	GO:0042127	37	0.040	Mouse
regulation of filopodium assembly	GO:0051489	2	0.040
epiboly	GO:0090504	41	0.040
morphogenesis of embryonic epithelium	GO:0016331	30	0.039
cellular localization	GO:0051641	97	0.039
regulation of production of molecular mediator of immune response	GO:0002700	1	0.039
regulation of heart contraction	GO:0008016	32	0.039
gastrulation with mouth forming second	GO:0001702	44	0.038
myotube differentiation	GO:0014902	45	0.038
melanin metabolic process	GO:0006582	2	0.038
hepaticobiliary system development	GO:0061008	98	0.038
cell part morphogenesis	GO:0032990	246	0.038	Mouse
signal transduction by phosphorylation	GO:0023014	18	0.037
growth	GO:0040007	174	0.037
positive regulation of embryonic development	GO:0040019	3	0.037
membrane organization	GO:0061024	21	0.037
leukocyte homeostasis	GO:0001776	2	0.036
regulation of synapse assembly	GO:0051963	3	0.036
regulation of phosphorus metabolic process	GO:0051174	43	0.036
developmental growth	GO:0048589	166	0.036
negative regulation of metabolic process	GO:0009892	86	0.036	Mouse
tissue remodeling	GO:0048771	4	0.036
protein localization	GO:0008104	40	0.036
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.036
organic substance transport	GO:0071702	58	0.036
stem cell differentiation	GO:0048863	117	0.036
response to organic substance	GO:0010033	153	0.035
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.035	Mouse
negative regulation of developmental process	GO:0051093	65	0.035
regulation of cell development	GO:0060284	100	0.035
membrane repolarization	GO:0086009	2	0.035
positive regulation of stem cell proliferation	GO:2000648	1	0.035
midbrain development	GO:0030901	28	0.034
positive regulation of cellular component movement	GO:0051272	11	0.034
bone morphogenesis	GO:0060349	11	0.034
central nervous system neuron differentiation	GO:0021953	74	0.034
determination of ventral identity	GO:0048264	21	0.034
negative regulation of macromolecule metabolic process	GO:0010605	76	0.034	Mouse
sprouting angiogenesis	GO:0002040	53	0.034
regulation of multicellular organism growth	GO:0040014	4	0.034
inner ear receptor cell development	GO:0060119	20	0.034
endodermal cell fate commitment	GO:0001711	18	0.034
positive regulation of catabolic process	GO:0009896	4	0.033
embryonic heart tube morphogenesis	GO:0003143	108	0.033
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.033
apoptotic process	GO:0006915	116	0.033	Mouse
positive regulation of rna metabolic process	GO:0051254	59	0.033	Zebrafish
stem cell development	GO:0048864	82	0.033
neuron projection guidance	GO:0097485	86	0.032	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	3	0.032	Mouse
cell growth	GO:0016049	57	0.032
g2 m transition of mitotic cell cycle	GO:0000086	4	0.032
regulation of defense response to virus by host	GO:0050691	1	0.032
cellular response to stress	GO:0033554	62	0.032
death	GO:0016265	121	0.032	Mouse
positive regulation of cytoskeleton organization	GO:0051495	3	0.032
positive regulation of neuron death	GO:1901216	1	0.032
cellular response to molecule of bacterial origin	GO:0071219	3	0.032
regulation of establishment of protein localization	GO:0070201	4	0.032
dorsal convergence	GO:0060030	14	0.032
regulation of cellular component movement	GO:0051270	55	0.032
retinal ganglion cell axon guidance	GO:0031290	35	0.032
growth plate cartilage morphogenesis	GO:0003422	1	0.031
leukocyte activation	GO:0045321	12	0.031
embryonic viscerocranium morphogenesis	GO:0048703	52	0.031
pancreatic d cell differentiation	GO:0003311	2	0.031
neuroblast differentiation	GO:0014016	1	0.031
appendage development	GO:0048736	80	0.031
axon extension involved in axon guidance	GO:0048846	10	0.031
lamellipodium assembly	GO:0030032	1	0.031
pathway restricted smad protein phosphorylation	GO:0060389	1	0.031
mapk cascade	GO:0000165	18	0.030
regulation of transport	GO:0051049	45	0.030
inner ear morphogenesis	GO:0042472	63	0.030
cell cycle g2 m phase transition	GO:0044839	4	0.030
auditory receptor cell fate commitment	GO:0009912	4	0.030
protein heterooligomerization	GO:0051291	1	0.030
astrocyte differentiation	GO:0048708	1	0.030
mesodermal cell fate specification	GO:0007501	12	0.029
regulation of reproductive process	GO:2000241	4	0.029
spinal cord anterior posterior patterning	GO:0021512	1	0.029
nephron tubule morphogenesis	GO:0072078	1	0.029
regulation of mesoderm development	GO:2000380	11	0.029
myeloid leukocyte mediated immunity	GO:0002444	1	0.029
heart morphogenesis	GO:0003007	156	0.028
cellular response to radiation	GO:0071478	4	0.028
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.028
endocytosis	GO:0006897	16	0.028
negative regulation of gene expression	GO:0010629	65	0.028	Mouse
positive regulation of cytokine production	GO:0001819	2	0.028
positive regulation of cell communication	GO:0010647	56	0.028	Mouse
ectodermal placode formation	GO:0060788	26	0.028
actin filament organization	GO:0007015	15	0.028
heart process	GO:0003015	71	0.027
embryonic digestive tract morphogenesis	GO:0048557	3	0.027
peripheral nervous system neuron axonogenesis	GO:0048936	13	0.027
endodermal cell fate specification	GO:0001714	17	0.027
regulation of catalytic activity	GO:0050790	55	0.027
insulin like growth factor receptor signaling pathway	GO:0048009	4	0.027
oligodendrocyte differentiation	GO:0048709	23	0.027
inner ear development	GO:0048839	126	0.027
pons development	GO:0021548	11	0.027
tyrosine phosphorylation of stat protein	GO:0007260	1	0.027
homeostatic process	GO:0042592	142	0.027
organelle organization	GO:0006996	227	0.027
regulation of endodermal cell fate specification	GO:0042663	15	0.027
positive regulation of cell motility	GO:2000147	11	0.027
negative regulation of response to stimulus	GO:0048585	104	0.027
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.026
foregut morphogenesis	GO:0007440	4	0.026
actin cytoskeleton organization	GO:0030036	63	0.026
detection of stimulus involved in sensory perception	GO:0050906	21	0.026
negative chemotaxis	GO:0050919	1	0.026
heart development	GO:0007507	313	0.026
positive regulation of epithelial cell proliferation	GO:0050679	1	0.026
axis specification	GO:0009798	43	0.026
regulation of gastrulation	GO:0010470	24	0.026
macromolecular complex subunit organization	GO:0043933	74	0.025
cell fate specification	GO:0001708	68	0.025
actin polymerization or depolymerization	GO:0008154	2	0.025
cytoskeleton organization	GO:0007010	96	0.025
positive regulation of epithelial cell differentiation	GO:0030858	2	0.025
regulation of axon extension involved in axon guidance	GO:0048841	6	0.025
response to molecule of bacterial origin	GO:0002237	14	0.025
nucleocytoplasmic transport	GO:0006913	4	0.025
positive regulation of striated muscle cell differentiation	GO:0051155	1	0.025
somatic stem cell maintenance	GO:0035019	1	0.025
embryonic neurocranium morphogenesis	GO:0048702	15	0.025
sensory perception	GO:0007600	39	0.025
convergent extension involved in organogenesis	GO:0060029	10	0.025
regulation of protein phosphorylation	GO:0001932	18	0.025
positive regulation of catalytic activity	GO:0043085	25	0.025
positive regulation of leukocyte differentiation	GO:1902107	1	0.025
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.025
cardiac atrium development	GO:0003230	4	0.025
system process	GO:0003008	185	0.025
zymogen activation	GO:0031638	3	0.024
cartilage morphogenesis	GO:0060536	13	0.024
intracellular estrogen receptor signaling pathway	GO:0030520	3	0.024
neuron projection extension involved in neuron projection guidance	GO:1902284	10	0.024
negative regulation of signal transduction	GO:0009968	94	0.024
regulation of mesenchymal cell proliferation	GO:0010464	1	0.024
phosphate containing compound metabolic process	GO:0006796	108	0.024	Human
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	1	0.024	Mouse
response to mechanical stimulus	GO:0009612	24	0.024
glomerulus development	GO:0032835	27	0.024
regulation of locomotion	GO:0040012	55	0.023
endocrine system development	GO:0035270	65	0.023
regulation of epithelial cell proliferation	GO:0050678	3	0.023	Mouse
cranial nerve morphogenesis	GO:0021602	15	0.023
swim bladder development	GO:0048794	19	0.023
regulation of synapse organization	GO:0050807	3	0.023
positive regulation of response to external stimulus	GO:0032103	9	0.023
leukocyte differentiation	GO:0002521	25	0.023
liver development	GO:0001889	96	0.023
intracellular transport	GO:0046907	32	0.023
regulation of protein transport	GO:0051223	3	0.023
positive regulation of secretion by cell	GO:1903532	1	0.023
multi organism process	GO:0051704	134	0.022
regulation of dna replication	GO:0006275	3	0.022
cellular response to abiotic stimulus	GO:0071214	4	0.022
positive regulation of rna biosynthetic process	GO:1902680	57	0.022	Zebrafish
rhombomere 5 development	GO:0021571	4	0.022
pronephros development	GO:0048793	69	0.022
response to abiotic stimulus	GO:0009628	122	0.022
aging	GO:0007568	2	0.022
detection of chemical stimulus	GO:0009593	4	0.022
regulation of cell migration	GO:0030334	40	0.022
erythrocyte differentiation	GO:0030218	54	0.021
histone h3 k4 methylation	GO:0051568	2	0.021
striated muscle tissue development	GO:0014706	110	0.021
neuron projection morphogenesis	GO:0048812	161	0.021	Mouse
positive regulation of tyrosine phosphorylation of stat protein	GO:0042531	1	0.021
meiotic chromosome segregation	GO:0045132	3	0.021
spinal cord radial glial cell differentiation	GO:0021531	2	0.021
defense response to fungus	GO:0050832	2	0.021
erythrocyte homeostasis	GO:0034101	55	0.021
morphogenesis of an epithelial fold	GO:0060571	1	0.021
regulation of biological quality	GO:0065008	263	0.021
neural crest cell migration	GO:0001755	42	0.021
negative regulation of epithelial cell migration	GO:0010633	1	0.021
positive regulation of cell cycle	GO:0045787	3	0.021
negative regulation of cell communication	GO:0010648	96	0.021
macromolecule localization	GO:0033036	54	0.021
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.021	Zebrafish
regulation of blood circulation	GO:1903522	32	0.021
venous blood vessel development	GO:0060841	9	0.020
regulation of cytokine production	GO:0001817	3	0.020
hatching	GO:0035188	4	0.020
cranial nerve development	GO:0021545	42	0.020
exocytosis	GO:0006887	1	0.020
regulation of leukocyte migration	GO:0002685	8	0.020
positive regulation of myeloid cell differentiation	GO:0045639	2	0.020
smooth muscle contraction	GO:0006939	2	0.020
positive regulation of phosphorus metabolic process	GO:0010562	21	0.019
otic placode formation	GO:0043049	23	0.019
negative regulation of embryonic development	GO:0045992	11	0.019
striated muscle cell differentiation	GO:0051146	129	0.019
activation of mapk activity	GO:0000187	3	0.019
positive regulation of cell migration	GO:0030335	11	0.019
organ formation	GO:0048645	17	0.019
cellular response to lipopolysaccharide	GO:0071222	3	0.018
cell projection morphogenesis	GO:0048858	244	0.018	Mouse

runx3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.059
connective tissue disease	DOID:65	0.019
bone development disease	DOID:0080006	0.019
bone disease	DOID:0080001	0.019
musculoskeletal system disease	DOID:17	0.019

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