Danio rerio

19 known processes

slc6a4a

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A

slc6a4a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
monoamine transportGO:001584410.205
primary amino compound metabolic processGO:190116010.200
amine metabolic processGO:000930820.175
system processGO:00030081850.159
generation of neuronsGO:00486993850.159
response to abiotic stimulusGO:00096281220.149
cellular amine metabolic processGO:004410620.140
digestive system developmentGO:00551232890.108
regulation of biological qualityGO:00650082630.103
Zebrafish Worm
larval developmentGO:000216420.093
organic cyclic compound biosynthetic processGO:19013622230.091
dopamine metabolic processGO:004241720.087
regulation of extrinsic apoptotic signaling pathwayGO:200123630.085
response to chemicalGO:00422213200.080
peptidyl serine phosphorylationGO:001810510.075
hematopoietic or lymphoid organ developmentGO:00485341910.075
indole containing compound metabolic processGO:004243020.074
single organism transportGO:00447652060.074
positive regulation of transportGO:005105020.074
primary amino compound biosynthetic processGO:190116210.073
regulation of metabolic processGO:00192223590.071
nucleobase containing compound metabolic processGO:00061392740.069
peptidyl serine modificationGO:001820920.068
small molecule metabolic processGO:0044281770.066
nitrogen compound metabolic processGO:00068073190.065
programmed cell deathGO:00125011190.065
maintenance of locationGO:005123540.063
cellular nitrogen compound metabolic processGO:00346412900.063
single organism behaviorGO:0044708240.061
circulatory system processGO:0003013870.060
regulation of nucleobase containing compound metabolic processGO:00192192500.059
organonitrogen compound metabolic processGO:1901564740.059
agingGO:000756820.058
heterocycle metabolic processGO:00464832900.055
synaptic transmission glycinergicGO:006001210.055
Zebrafish
serotonin metabolic processGO:004242810.053
i kappab kinase nf kappab signalingGO:000724940.053
catecholamine metabolic processGO:000658420.051
nucleic acid metabolic processGO:00903042440.051
catechol containing compound metabolic processGO:000971220.050
behaviorGO:0007610740.049
Zebrafish
organic acid metabolic processGO:0006082310.049
lipid storageGO:001991510.048
single organism metabolic processGO:00447102170.048
nucleocytoplasmic transportGO:000691340.048
regulation of glucose importGO:004632410.047
negative regulation of protein kinase activityGO:000646940.046
positive regulation of i kappab kinase nf kappab signalingGO:004312330.046
cellular biosynthetic processGO:00442492860.046
regulation of cellular amine metabolic processGO:003323800.045
regulation of programmed cell deathGO:00430671010.045
phototransduction visible lightGO:000760320.044
membrane hyperpolarizationGO:006008110.044
Zebrafish
negative regulation of dna metabolic processGO:005105340.044
sequestering of metal ionGO:005123830.043
single organism biosynthetic processGO:0044711710.043
cell surface receptor signaling pathwayGO:00071663250.042
single organism localizationGO:19025782250.042
cellular amino acid metabolic processGO:000652070.042
cellular response to external stimulusGO:007149620.042
regulation of heart contractionGO:0008016320.041
cellular macromolecule metabolic processGO:00442603910.041
phosphorus metabolic processGO:00067931090.040
extrinsic apoptotic signaling pathwayGO:009719130.040
regulation of cytoplasmic transportGO:190364940.040
hemopoiesisGO:00300971830.039
cellular response to oxygen levelsGO:007145310.039
response to estrogenGO:0043627270.039
g protein coupled receptor signaling pathwayGO:0007186740.039
protein localization to nucleusGO:003450430.039
regulation of glucose transportGO:001082710.038
regulation of i kappab kinase nf kappab signalingGO:004312240.038
regulation of bindingGO:005109830.038
leukocyte proliferationGO:007066110.037
alpha amino acid metabolic processGO:190160530.037
catechol containing compound biosynthetic processGO:000971320.037
regulation of rna biosynthetic processGO:20011412130.037
regulation of circadian sleep wake cycle sleepGO:004518710.037
cellular protein modification processGO:00064641000.036
sprouting angiogenesisGO:0002040530.036
regulation of intracellular protein transportGO:003315730.035
glucose importGO:004632320.035
negative regulation of nucleobase containing compound metabolic processGO:0045934590.035
type b pancreatic cell developmentGO:000332340.034
carboxylic acid metabolic processGO:0019752220.034
neuron neuron synaptic transmissionGO:000727010.034
Zebrafish
organonitrogen compound biosynthetic processGO:1901566470.034
organic substance biosynthetic processGO:19015762890.033
gene expressionGO:00104672520.033
locomotionGO:00400113130.033
regulation of localizationGO:00328791040.033
establishment of localization in cellGO:0051649770.033
immune system developmentGO:00025201910.033
cellular aromatic compound metabolic processGO:00067252950.032
autophagyGO:000691440.032
muscle structure developmentGO:00610611960.032
phagocytosisGO:000690930.032
organelle organizationGO:00069962270.031
circadian sleep wake cycle processGO:002241020.031
regulation of molecular functionGO:0065009700.031
regulation of cellular metabolic processGO:00313233200.031
negative regulation of protein phosphorylationGO:000193340.031
neurotransmitter secretionGO:000726920.031
neurological system processGO:0050877620.030
regulation of protein localization to nucleusGO:190018020.030
cellular localizationGO:0051641970.030
blood vessel morphogenesisGO:00485142160.030
regulation of cellular ketone metabolic processGO:001056570.030
cellular response to hormone stimulusGO:0032870390.030
sensory organ developmentGO:00074233930.030
response to drugGO:004249330.030
positive regulation of cellular amine metabolic processGO:003324000.030
mononuclear cell proliferationGO:003294310.029
chemotaxisGO:00069351040.029
negative regulation of kinase activityGO:003367340.029
nitrogen compound transportGO:0071705230.029
regulation of reproductive processGO:200024140.029
regulation of dendrite developmentGO:005077330.029
response to stressGO:00069502630.029
eye morphogenesisGO:00485921440.029
neuron differentiationGO:00301823530.028
transmembrane transportGO:00550851200.028
regulation of neurotransmitter transportGO:005158810.028
regulation of cytokine productionGO:000181730.028
blood circulationGO:0008015870.028
positive regulation of cell cycleGO:004578730.028
regulation of inflammatory responseGO:005072720.028
digestive tract mesoderm developmentGO:000750210.027
positive regulation of cellular amino acid metabolic processGO:004576400.027
positive regulation of cellular component biogenesisGO:004408930.027
circadian sleep wake cycleGO:004274520.026
nuclear transportGO:005116940.026
female sex differentiationGO:004666040.026
regulation of signalingGO:00230512350.026
Zebrafish
organelle localizationGO:0051640490.026
eye developmentGO:00016542770.026
locomotory behaviorGO:0007626340.025
Zebrafish
regulation of protein bindingGO:004339330.025
oxoacid metabolic processGO:0043436310.025
regulation of cellular amino acid metabolic processGO:000652100.025
regulation of cell communicationGO:00106462320.025
Zebrafish
positive regulation of secretion by cellGO:190353210.025
single organism membrane fusionGO:004480120.025
cellular response to nutrient levelsGO:003166920.025
regulation of multicellular organismal processGO:00512392770.025
regulation of signal transductionGO:00099662250.024
positive regulation of apoptotic processGO:0043065290.024
sensory perceptionGO:0007600390.024
muscle cell migrationGO:001481240.024
cellular carbohydrate metabolic processGO:004426240.024
positive regulation of biological processGO:00485182530.024
regulation of protein transportGO:005122330.024
l amino acid transportGO:001580710.023
Zebrafish
signal transduction in absence of ligandGO:003803410.023
regulation of peptidyl tyrosine phosphorylationGO:005073010.023
response to ketoneGO:190165410.023
amino acid transportGO:000686520.023
Zebrafish
positive regulation of cell adhesionGO:004578510.023
enzyme linked receptor protein signaling pathwayGO:00071671060.023
cellular component assemblyGO:00226071700.023
blood vessel developmentGO:00015682460.023
signal transductionGO:00071654550.023
cell substrate adhesionGO:003158940.022
cellular response to radiationGO:007147840.022
negative regulation of cellular processGO:00485232830.022
regulation of cell activationGO:005086510.022
regulation of cellular component organizationGO:0051128860.022
cellular response to starvationGO:000926710.022
regulation of gene expressionGO:00104682650.022
positive regulation of cellular processGO:00485222010.022
energy reserve metabolic processGO:000611220.022
heart processGO:0003015710.021
regulation of nucleocytoplasmic transportGO:004682220.021
positive regulation of cell activationGO:005086710.021
protein modification processGO:00362111000.021
nuclear importGO:005117030.021
macromolecule modificationGO:00434121110.021
myeloid cell differentiationGO:0030099860.021
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.021
metal ion homeostasisGO:0055065260.021
regulation of catalytic activityGO:0050790550.021
regulation of membrane potentialGO:0042391230.021
Zebrafish
phototransductionGO:000760220.021
positive regulation of inflammatory responseGO:005072910.020
transportGO:00068102200.020
single organism organelle organizationGO:19025891990.020
digestive tract developmentGO:00485652650.020
erythrocyte homeostasisGO:0034101550.020
retina development in camera type eyeGO:00600411460.020
regulation of apoptotic processGO:0042981980.020
regulation of neurotransmitter secretionGO:004692810.020
protein metabolic processGO:00195381830.020
camera type eye developmentGO:00430102220.020
positive regulation of cytoskeleton organizationGO:005149530.020
biosynthetic processGO:00090582940.020
regulation of cell shapeGO:000836010.020
dopamine biosynthetic processGO:004241620.020
growthGO:00400071740.020
taxisGO:00423301090.020
absorption of visible lightGO:001603820.020
regulation of muscle hypertrophyGO:001474320.020
cyclic purine nucleotide metabolic processGO:0052652180.019
establishment of protein localization to organelleGO:007259440.019
sequestering of calcium ionGO:005120830.019
adult behaviorGO:003053420.019
regulation of cellular biosynthetic processGO:00313262450.019
multicellular organismal response to stressGO:003355520.019
muscle hypertrophyGO:001489620.019
positive regulation of secretionGO:005104710.019
catecholamine biosynthetic processGO:004242320.019
phosphate containing compound metabolic processGO:00067961080.019
cell part morphogenesisGO:00329902460.019
aromatic amino acid family metabolic processGO:000907210.019
nucleobase containing compound biosynthetic processGO:00346542050.019
heterocycle biosynthetic processGO:00181302150.019
glucose homeostasisGO:004259310.019
protein import into nucleusGO:000660630.018
organic cyclic compound metabolic processGO:19013603010.018
protein targeting to nucleusGO:004474430.018
ion transportGO:00068111140.018
cell deathGO:00082191210.018
intracellular signal transductionGO:0035556850.018
somatic muscle developmentGO:000752540.018
positive regulation of cell communicationGO:0010647560.018
modification dependent macromolecule catabolic processGO:004363230.018
cellular nitrogen compound biosynthetic processGO:00442712180.018
nuclear migrationGO:000709730.018
camera type eye morphogenesisGO:00485931080.018
mitochondrion organizationGO:000700540.018
cellular ketone metabolic processGO:0042180110.018
establishment of localizationGO:00512342440.018
regulation of primary metabolic processGO:00800903110.018
negative regulation of catabolic processGO:000989530.017
regulation of system processGO:0044057400.017
ubiquitin dependent protein catabolic processGO:000651130.017
cellular response to extracellular stimulusGO:003166820.017
oxidation reduction processGO:0055114410.017
organelle fusionGO:004828430.017
regulation of protein import into nucleusGO:004230620.017
lymphocyte proliferationGO:004665110.017
mesoderm developmentGO:0007498880.017
regulation of macromolecule biosynthetic processGO:00105562250.017
apoptotic processGO:00069151160.017
cellular biogenic amine metabolic processGO:000657620.017
regulation of cell deathGO:00109411030.017
response to steroid hormoneGO:0048545350.017
synaptic vesicle localizationGO:009747910.017
macromolecular complex disassemblyGO:003298410.017
proteasomal protein catabolic processGO:001049820.017
cellular macromolecule biosynthetic processGO:00346452240.017
lipid metabolic processGO:0006629520.017
multicellular organismal metabolic processGO:004423620.017
phenol containing compound biosynthetic processGO:004618940.016
immune system processGO:00023762410.016
phosphorylationGO:0016310690.016
cell substrate junction assemblyGO:000704420.016
development of primary female sexual characteristicsGO:004654540.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.016
response to temperature stimulusGO:0009266150.016
serotonin biosynthetic processGO:004242710.016
protein polymerizationGO:005125840.016
negative regulation of cell deathGO:0060548600.016
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.016
response to light stimulusGO:0009416460.016
female gonad developmentGO:000858540.016
response to oxygen levelsGO:0070482250.016
multicellular organism growthGO:003526440.016
anion transportGO:0006820380.016
Zebrafish
protein complex disassemblyGO:004324110.015
cellular protein metabolic processGO:00442671290.015
regulation of cellular carbohydrate metabolic processGO:001067540.015
locomotor rhythmGO:004547530.015
regulation of establishment of protein localizationGO:007020140.015
axon extensionGO:0048675450.015
retina morphogenesis in camera type eyeGO:0060042790.015
regulation of nitrogen compound metabolic processGO:00511712510.015
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.015
regulation of response to stimulusGO:00485832690.015
response to glucoseGO:000974930.015
regulation of metal ion transportGO:001095940.015
cellular component biogenesisGO:00440851780.015
chemical homeostasisGO:0048878490.015
myeloid cell homeostasisGO:0002262560.015
erythrocyte differentiationGO:0030218540.015
ovulation cycle processGO:002260220.015
regulation of biosynthetic processGO:00098892500.015
developmental growthGO:00485891660.015
neutral amino acid transportGO:001580420.015
Zebrafish
cellular protein catabolic processGO:004425740.015
positive regulation of cytosolic calcium ion concentrationGO:000720440.015
cellular response to chemical stimulusGO:00708871570.015
cellular component disassemblyGO:002241110.015
proteolysis involved in cellular protein catabolic processGO:005160330.015
adherens junction organizationGO:003433240.015
establishment of organelle localizationGO:0051656450.014
modification dependent protein catabolic processGO:001994130.014
embryonic organ developmentGO:00485683810.014
neuron developmentGO:00486662620.014
transcription dna templatedGO:00063511810.014
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.014
homeostatic processGO:00425921420.014
developmental growth involved in morphogenesisGO:0060560860.014
regulation of carbohydrate metabolic processGO:000610940.014
regenerationGO:0031099910.014
cell cell junction maintenanceGO:004521710.014
regulation of wound healingGO:006104120.014
regulation of phosphorus metabolic processGO:0051174430.014
cell cycle g2 m phase transitionGO:004483940.014
negative regulation of protein serine threonine kinase activityGO:007190120.014
regulation of protein catabolic processGO:004217610.014
retinal ganglion cell axon guidanceGO:0031290350.014
positive regulation of macromolecule metabolic processGO:0010604930.014
cellular amino acid biosynthetic processGO:000865220.013
positive regulation of jak stat cascadeGO:004642720.013
response to alkaloidGO:004327920.013
regulation of protein complex assemblyGO:004325430.013
regulation of nucleotide catabolic processGO:003081120.013
regulation of behaviorGO:0050795240.013
macromolecule localizationGO:0033036540.013
transmission of nerve impulseGO:0019226190.013
regulation of nucleoside metabolic processGO:000911820.013
response to monosaccharideGO:003428430.013
hormone secretionGO:004687920.013
production of molecular mediator of immune responseGO:000244020.013
regulation of intracellular signal transductionGO:1902531570.013
glucocorticoid biosynthetic processGO:000670410.013
negative regulation of programmed cell deathGO:0043069580.013
nuclear exportGO:005116810.013
response to lipidGO:0033993600.013
guanosine containing compound metabolic processGO:190106840.013
negative regulation of intracellular transportGO:003238730.013
negative regulation of cytoplasmic transportGO:190365020.013
rna biosynthetic processGO:00327741810.013
positive regulation of catabolic processGO:000989640.013
regulation of autophagyGO:001050630.013
synaptic vesicle transportGO:004848910.013
establishment of synaptic vesicle localizationGO:009748010.013
cell matrix adhesionGO:000716040.013
positive regulation of glucose importGO:004632610.013
positive regulation of nitrogen compound metabolic processGO:0051173690.013
endocrine processGO:005088620.013
cellular response to decreased oxygen levelsGO:003629410.013
odontogenesis of dentin containing toothGO:004247510.013
response to glucocorticoidGO:005138410.013
cellular response to lipidGO:0071396390.013
protein depolymerizationGO:005126110.013
response to corticosteroidGO:003196010.013
regulation of microtubule cytoskeleton organizationGO:007050730.013
response to organic substanceGO:00100331530.013
nucleic acid templated transcriptionGO:00976591810.013
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.013
positive regulation of cell deathGO:0010942290.013
regulation of response to extracellular stimulusGO:003210410.013
erk1 and erk2 cascadeGO:007037140.012
rhodopsin mediated signaling pathwayGO:001605610.012
neuronal action potentialGO:0019228180.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
meiotic nuclear divisionGO:000712640.012
regulation of mrna processingGO:005068430.012
carbohydrate homeostasisGO:003350010.012
rna metabolic processGO:00160702190.012
response to woundingGO:00096111160.012
carbohydrate biosynthetic processGO:001605110.012
synaptic growth at neuromuscular junctionGO:005112420.012
cell morphogenesisGO:00009022890.012
positive regulation of cell divisionGO:005178120.012
striated muscle tissue developmentGO:00147061100.012
ovarian follicle developmentGO:000154120.012
positive regulation of neuron apoptotic processGO:004352510.012
cell projection assemblyGO:0030031640.012
negative regulation of defense responseGO:003134820.012
vasculature developmentGO:00019442780.012
ribonucleotide biosynthetic processGO:0009260200.012
neuron projection guidanceGO:0097485860.012
sensory perception of painGO:001923310.012
regulation of organelle organizationGO:0033043290.012
regulation of cellular phGO:003064110.012
detection of stimulusGO:0051606290.012
response to nutrientGO:000758430.012
activation of mapk activityGO:000018730.012
gland developmentGO:00487321430.012
stem cell divisionGO:001714510.012
cellular response to steroid hormone stimulusGO:0071383310.011
response to carbohydrateGO:000974330.011
cyclic nucleotide biosynthetic processGO:0009190180.011
regulation of erk1 and erk2 cascadeGO:007037240.011
developmental cell growthGO:0048588520.011
phagocytosis engulfmentGO:000691110.011
regulation of dna recombinationGO:000001820.011
adherens junction maintenanceGO:003433420.011
germ line stem cell maintenanceGO:003071820.011
guanosine containing compound catabolic processGO:190106920.011
positive regulation of neuron projection developmentGO:001097690.011
sensory organ morphogenesisGO:00905962000.011
negative regulation of epithelial cell proliferationGO:005068010.011
positive regulation of rho protein signal transductionGO:003502500.011
organic substance transportGO:0071702580.011
sensory perception of smellGO:000760820.011
regulation of circadian rhythmGO:004275240.011
regulation of protein polymerizationGO:003227120.011
axon developmentGO:00615641660.011
mitotic recombinationGO:000631220.011
hormone transportGO:000991420.011
exocytosisGO:000688710.011
sleepGO:003043110.011
protein importGO:001703830.011
membrane invaginationGO:001032410.011
regulation of protein targetingGO:190353320.011
peptide transportGO:001583310.011
cytoskeleton organizationGO:0007010960.011
ovulation cycleGO:004269820.011
organic hydroxy compound transportGO:0015850140.011
localization of cellGO:00516742440.011
regulation of transportGO:0051049450.011
tissue regenerationGO:0042246740.011
regulation of rna metabolic processGO:00512522240.011
cellular response to hypoxiaGO:007145610.011
cell chemotaxisGO:0060326170.011
cellular transition metal ion homeostasisGO:004691630.011
cellular macromolecule localizationGO:0070727210.011
positive regulation of lipid metabolic processGO:004583410.011
vesicle localizationGO:0051648270.011
positive regulation of response to stimulusGO:0048584800.011
microtubule organizing center organizationGO:003102310.011
actin filament polymerizationGO:003004120.011
cell junction maintenanceGO:003433120.011
response to hormoneGO:0009725480.011
smooth muscle contractionGO:000693920.011
cortical cytoskeleton organizationGO:003086510.011
neurotransmitter transportGO:000683620.010
Worm
leukocyte chemotaxisGO:0030595120.010
protein localization to plasma membraneGO:007265910.010
meiotic cell cycle processGO:190304630.010
regulation of cellular macromolecule biosynthetic processGO:20001122220.010
response to hexoseGO:000974630.010
regulation of cellular protein catabolic processGO:190336210.010
cell migrationGO:00164772370.010
positive regulation of apoptotic signaling pathwayGO:200123510.010
neural crest cell migrationGO:0001755420.010
heart developmentGO:00075073130.010
chemosensory behaviorGO:000763510.010
regulation of anatomical structure sizeGO:0090066330.010
cellular ion homeostasisGO:0006873170.010
regulation of protein ubiquitinationGO:003139630.010
negative regulation of mapk cascadeGO:004340940.010
release of sequestered calcium ion into cytosolGO:005120930.010
positive regulation of glucose transportGO:001082810.010

slc6a4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.075
cardiovascular system diseaseDOID:128700.036
nervous system diseaseDOID:86300.015
cancerDOID:16200.013
organ system cancerDOID:005068600.013
disease of cellular proliferationDOID:1456600.013
disease of metabolismDOID:001466700.012