Danio rerio

0 known processes

pdk2

pyruvate dehydrogenase kinase, isoenzyme 2

(Aliases: Pdk,MGC56209,zgc:56209)

pdk2 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dicarboxylic acid transportGO:000683510.140
cellular aromatic compound metabolic processGO:00067252950.128
single organism localizationGO:19025782250.106
anion transportGO:0006820380.099
sulfate transmembrane transportGO:190235820.095
single organism transportGO:00447652060.072
organic cyclic compound metabolic processGO:19013603010.068
rna biosynthetic processGO:00327741810.066
nucleobase containing compound biosynthetic processGO:00346542050.063
establishment of protein localization to organelleGO:007259440.062
extrinsic apoptotic signaling pathwayGO:009719130.062
negative regulation of biological processGO:00485193040.060
cell surface receptor signaling pathwayGO:00071663250.058
nucleic acid templated transcriptionGO:00976591810.057
regulation of cellular biosynthetic processGO:00313262450.057
regulation of rna metabolic processGO:00512522240.057
aromatic compound biosynthetic processGO:00194382170.056
response to chemicalGO:00422213200.056
response to abiotic stimulusGO:00096281220.056
peptidyl serine phosphorylationGO:001810510.056
hemopoiesisGO:00300971830.055
positive regulation of transportGO:005105020.053
transportGO:00068102200.052
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.051
amine metabolic processGO:000930820.050
regulation of transcription dna templatedGO:00063552130.050
lipid storageGO:001991510.048
regulation of multicellular organism growthGO:004001440.047
organic cyclic compound biosynthetic processGO:19013622230.046
response to stressGO:00069502630.045
cellular macromolecule metabolic processGO:00442603910.044
maintenance of locationGO:005123540.043
brain developmentGO:00074202930.042
response to corticosteroidGO:003196010.042
biosynthetic processGO:00090582940.042
nucleobase containing compound metabolic processGO:00061392740.041
cellular macromolecule biosynthetic processGO:00346452240.041
response to external stimulusGO:00096052640.040
hematopoietic or lymphoid organ developmentGO:00485341910.040
cellular nitrogen compound biosynthetic processGO:00442712180.040
regulation of nucleobase containing compound metabolic processGO:00192192500.040
larval developmentGO:000216420.040
regulation of rna biosynthetic processGO:20011412130.039
peptidyl serine modificationGO:001820920.039
signal transduction in absence of ligandGO:003803410.039
establishment of localizationGO:00512342440.039
regulation of primary metabolic processGO:00800903110.038
nuclear importGO:005117030.038
nitrogen compound metabolic processGO:00068073190.037
cellular response to chemical stimulusGO:00708871570.037
head developmentGO:00603223030.037
adult behaviorGO:003053420.036
regulation of dendrite developmentGO:005077330.036
cellular response to external stimulusGO:007149620.035
ion transportGO:00068111140.035
heterocycle metabolic processGO:00464832900.035
cellular ketone metabolic processGO:0042180110.034
regulation of biosynthetic processGO:00098892500.034
cellular nitrogen compound metabolic processGO:00346412900.034
immune system developmentGO:00025201910.034
regulation of cellular metabolic processGO:00313233200.034
multicellular organism growthGO:003526440.033
cellular amine metabolic processGO:004410620.033
nucleocytoplasmic transportGO:000691340.033
entrainment of circadian clockGO:000964920.033
agingGO:000756820.033
cellular biosynthetic processGO:00442492860.033
positive regulation of cellular amino acid metabolic processGO:004576400.033
single organism nuclear importGO:190259330.032
regulation of jak stat cascadeGO:004642530.032
deathGO:00162651210.031
enzyme linked receptor protein signaling pathwayGO:00071671060.031
protein localization to nucleusGO:003450430.030
regulation of stem cell proliferationGO:007209120.030
phagocytosisGO:000690930.030
embryonic organ developmentGO:00485683810.030
stem cell proliferationGO:007208940.030
nuclear transportGO:005116940.030
positive regulation of cellular component biogenesisGO:004408930.029
cellular component disassemblyGO:002241110.029
response to decreased oxygen levelsGO:0036293250.029
mitochondrion organizationGO:000700540.029
gene expressionGO:00104672520.028
locomotor rhythmGO:004547530.028
regulation of metal ion transportGO:001095940.028
protein targeting to nucleusGO:004474430.028
oxoacid metabolic processGO:0043436310.027
oocyte maturationGO:000155640.027
positive regulation of map kinase activityGO:004340630.027
protein importGO:001703830.027
response to transition metal nanoparticleGO:1990267280.026
cell projection organizationGO:00300302840.026
morphogenesis of an epitheliumGO:00020093330.026
regulation of response to stimulusGO:00485832690.026
response to drugGO:004249330.026
cellular response to extracellular stimulusGO:003166820.026
protein import into nucleusGO:000660630.026
small molecule metabolic processGO:0044281770.026
regulation of cytokine productionGO:000181730.026
regulation of cellular amino acid metabolic processGO:000652100.026
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.026
organic substance biosynthetic processGO:19015762890.025
nucleic acid metabolic processGO:00903042440.025
tissue remodelingGO:004877140.025
cell part morphogenesisGO:00329902460.025
response to nutrientGO:000758430.025
secondary metabolic processGO:001974830.025
protein acetylationGO:000647320.025
regulation of signalingGO:00230512350.025
transcription dna templatedGO:00063511810.024
cellular response to hypoxiaGO:007145610.024
regulation of cellular amine metabolic processGO:003323800.024
positive regulation of protein kinase b signalingGO:005189710.023
regulation of meiotic cell cycleGO:005144510.023
steroid hormone secretionGO:003592910.023
nephron epithelium morphogenesisGO:007208810.023
positive regulation of apoptotic signaling pathwayGO:200123510.023
regulation of metabolic processGO:00192223590.023
g1 s transition of mitotic cell cycleGO:000008210.023
wnt signaling pathwayGO:0016055800.023
regulation of epithelial cell proliferationGO:005067830.023
positive regulation of cellular amine metabolic processGO:003324000.023
organic substance transportGO:0071702580.023
macromolecular complex disassemblyGO:003298410.023
internal protein amino acid acetylationGO:000647520.022
somatic muscle developmentGO:000752540.022
nephron tubule morphogenesisGO:007207810.022
autophagyGO:000691440.022
transcription from rna polymerase ii promoterGO:0006366800.022
protein acylationGO:004354330.022
blood vessel morphogenesisGO:00485142160.022
single organism membrane fusionGO:004480120.022
regulation of cellular ketone metabolic processGO:001056570.022
chordate embryonic developmentGO:00430092710.022
regulation of macromolecule metabolic processGO:00602553170.022
negative regulation of nuclear divisionGO:005178430.022
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.022
regulation of nucleic acid templated transcriptionGO:19035062130.021
single organism metabolic processGO:00447102170.021
negative regulation of cellular processGO:00485232830.021
rna metabolic processGO:00160702190.021
renal tubule morphogenesisGO:006133310.021
endocrine processGO:005088620.021
cellular response to decreased oxygen levelsGO:003629410.021
cellular monovalent inorganic cation homeostasisGO:003000420.021
response to glucocorticoidGO:005138410.021
cellular response to organic substanceGO:00713101050.021
cellular amino acid metabolic processGO:000652070.021
digestive system developmentGO:00551232890.021
response to uvGO:000941130.021
regulation of bindingGO:005109830.021
regulation of protein localization to nucleusGO:190018020.020
cognitionGO:005089010.020
response to alkaloidGO:004327920.020
blood vessel developmentGO:00015682460.020
homeostatic processGO:00425921420.020
signal transductionGO:00071654550.020
neuroblast proliferationGO:000740520.020
ion transmembrane transportGO:0034220910.020
sensory perception of painGO:001923310.020
synaptic growth at neuromuscular junctionGO:005112420.020
muscle cell migrationGO:001481240.020
regulation of neural precursor cell proliferationGO:200017730.020
organelle fusionGO:004828430.020
cellular carbohydrate metabolic processGO:004426240.020
regulation of extrinsic apoptotic signaling pathwayGO:200123630.020
peptidyl lysine acetylationGO:001839420.020
regulation of erk1 and erk2 cascadeGO:007037240.020
regulation of cellular macromolecule biosynthetic processGO:20001122220.019
cellular response to starvationGO:000926710.019
regulation of peptidyl tyrosine phosphorylationGO:005073010.019
protein metabolic processGO:00195381830.019
regulation of cellular phGO:003064110.019
carboxylic acid metabolic processGO:0019752220.019
cellular response to nutrient levelsGO:003166920.019
response to hypoxiaGO:0001666250.019
regulation of developmental processGO:00507932470.019
protein modification processGO:00362111000.019
generation of neuronsGO:00486993850.019
regulation of dna templated transcription in response to stressGO:004362000.019
cell cycle g1 s phase transitionGO:004484310.019
internal peptidyl lysine acetylationGO:001839320.019
protein complex disassemblyGO:004324110.019
response to hydrogen peroxideGO:004254230.019
regulation of circadian rhythmGO:004275240.019
cellular component movementGO:00069283350.019
response to foodGO:003209410.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.019
regulation of establishment of protein localizationGO:007020140.019
neuron differentiationGO:00301823530.019
positive regulation of canonical wnt signaling pathwayGO:009026340.018
female sex differentiationGO:004666040.018
regulation of hormone secretionGO:004688320.018
organic acid metabolic processGO:0006082310.018
glucose homeostasisGO:004259310.018
regulation of cell shapeGO:000836010.018
positive regulation of secretionGO:005104710.018
vasculature developmentGO:00019442780.018
response to topologically incorrect proteinGO:003596620.018
recombinational repairGO:000072510.018
positive regulation of biological processGO:00485182530.018
insulin like growth factor receptor signaling pathwayGO:004800940.018
regulation of biological qualityGO:00650082630.018
regulation of muscle contractionGO:000693730.018
regulation of nucleocytoplasmic transportGO:004682220.018
regulation of protein complex assemblyGO:004325430.018
renal system developmentGO:0072001940.018
regulation of macromolecule biosynthetic processGO:00105562250.018
stem cell maintenanceGO:001982740.018
cell matrix adhesionGO:000716040.018
positive regulation of immune effector processGO:000269930.018
nephron morphogenesisGO:007202820.018
positive regulation of secretion by cellGO:190353210.017
regulation of gene expressionGO:00104682650.017
heterocycle biosynthetic processGO:00181302150.017
microtubule organizing center organizationGO:003102310.017
central nervous system developmentGO:00074173870.017
response to unfolded proteinGO:000698620.017
mitochondrial transportGO:000683920.017
developmental programmed cell deathGO:001062340.017
hormone secretionGO:004687920.017
negative regulation of signalingGO:0023057960.017
regulation of phGO:000688530.017
regulation of protein transportGO:005122330.017
cell morphogenesis involved in differentiationGO:00009041950.017
positive regulation of catabolic processGO:000989640.017
mononuclear cell proliferationGO:003294310.017
cell morphogenesisGO:00009022890.017
response to organic substanceGO:00100331530.017
purine ribonucleoside monophosphate catabolic processGO:000916940.017
regulation of stem cell differentiationGO:200073640.017
positive regulation of cytokine productionGO:000181920.017
regulation of epithelial to mesenchymal transitionGO:001071730.017
protein secretionGO:000930610.017
cell projection morphogenesisGO:00488582440.017
response to copper ionGO:0046688130.017
phosphorus metabolic processGO:00067931090.017
regulation of endothelial cell proliferationGO:000193610.017
lateral inhibitionGO:004633110.016
negative regulation of catabolic processGO:000989530.016
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.016
negative regulation of ras protein signal transductionGO:004658010.016
metal ion transportGO:0030001580.016
positive regulation of jnk cascadeGO:004633030.016
apoptotic processGO:00069151160.016
embryonic hemopoiesisGO:0035162530.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
digestive tract developmentGO:00485652650.016
cell cycle arrestGO:000705010.016
cellular response to oxygen levelsGO:007145310.016
organonitrogen compound metabolic processGO:1901564740.016
positive regulation of cell cycleGO:004578730.016
positive regulation of stress activated mapk cascadeGO:003287430.016
response to salt stressGO:0009651100.016
regulation of protein targetingGO:190353320.016
regulation of sodium ion transportGO:000202820.016
negative regulation of secretionGO:005104820.016
regulation of signal transductionGO:00099662250.016
regulation of protein catabolic processGO:004217610.016
negative regulation of protein phosphorylationGO:000193340.016
cellular protein metabolic processGO:00442671290.016
regulation of response to nutrient levelsGO:003210710.016
positive regulation of muscle cell differentiationGO:005114910.016
macroautophagyGO:001623610.015
response to light stimulusGO:0009416460.015
regulation of cell differentiationGO:00455951420.015
regulation of blood vessel sizeGO:005088020.015
protein dephosphorylationGO:000647030.015
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.015
regulation of anatomical structure morphogenesisGO:00226031300.015
negative regulation of response to stimulusGO:00485851040.015
system processGO:00030081850.015
cellular response to topologically incorrect proteinGO:003596720.015
cell substrate adhesionGO:003158940.015
carbohydrate biosynthetic processGO:001605110.015
positive regulation of lymphocyte mediated immunityGO:000270810.015
response to endogenous stimulusGO:0009719830.015
positive regulation of cell adhesionGO:004578510.015
cellular component biogenesisGO:00440851780.015
organic acid transportGO:001584990.015
positive regulation of stem cell proliferationGO:200064810.015
cellular component morphogenesisGO:00329893360.015
compound eye developmentGO:004874920.015
spermatid developmentGO:000728620.015
positive regulation of cell activationGO:005086710.015
regulation of calcium ion transportGO:005192420.015
negative regulation of secretion by cellGO:190353120.015
centrosome organizationGO:005129710.015
guanosine containing compound metabolic processGO:190106840.015
cellular response to endogenous stimulusGO:0071495680.015
regulation of inflammatory responseGO:005072720.015
cellular protein modification processGO:00064641000.015
positive regulation of nitrogen compound metabolic processGO:0051173690.015
positive regulation of metabolic processGO:00098931080.015
membrane fusionGO:006102520.015
regulation of receptor activityGO:001046920.015
heart developmentGO:00075073130.015
leukocyte proliferationGO:007066110.015
regulation of cell communicationGO:00106462320.015
negative regulation of biosynthetic processGO:0009890550.015
dna templated transcription initiationGO:000635210.014
lymphocyte proliferationGO:004665110.014
erk1 and erk2 cascadeGO:007037140.014
ribonucleoside monophosphate catabolic processGO:000915840.014
nucleoside monophosphate catabolic processGO:000912540.014
positive regulation of cytoskeleton organizationGO:005149530.014
regulation of filopodium assemblyGO:005148920.014
regulation of protein import into nucleusGO:004230620.014
immune system processGO:00023762410.014
positive regulation of chromatin modificationGO:190331010.014
positive regulation of epithelial cell migrationGO:001063420.014
macromolecule biosynthetic processGO:00090592270.014
organic anion transportGO:0015711150.014
negative regulation of protein kinase activityGO:000646940.014
negative regulation of signal transductionGO:0009968940.014
sensory organ morphogenesisGO:00905962000.014
synaptic vesicle transportGO:004848910.014
gland developmentGO:00487321430.014
kidney developmentGO:0001822920.014
protein polymerizationGO:005125840.014
cellular transition metal ion homeostasisGO:004691630.014
multicellular organismal response to stressGO:003355520.014
urogenital system developmentGO:0001655970.014
multi organism processGO:00517041340.014
pancreas developmentGO:0031016840.014
golgi vesicle transportGO:004819330.014
organ regenerationGO:003110010.014
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.014
muscle structure developmentGO:00610611960.014
regulation of protein bindingGO:004339330.014
sleepGO:003043110.014
alpha amino acid metabolic processGO:190160530.014
positive regulation of leukocyte mediated immunityGO:000270510.014
negative regulation of cell communicationGO:0010648960.013
centrosome duplicationGO:005129810.013
response to radiationGO:0009314510.013
response to monosaccharideGO:003428430.013
regulation of multicellular organismal developmentGO:20000262230.013
regulation of cell activationGO:005086510.013
neurotransmitter transportGO:000683620.013
response to ketoneGO:190165410.013
spermatid differentiationGO:004851520.013
exocytosisGO:000688710.013
regulation of multicellular organismal processGO:00512392770.013
regulation of mrna processingGO:005068430.013
cellular response to biotic stimulusGO:007121630.013
regulation of response to cytokine stimulusGO:006075930.013
phosphatidylinositol mediated signalingGO:004801520.013
response to glucoseGO:000974930.013
positive regulation of chromosome organizationGO:200125210.013
positive regulation of translationGO:004572710.013
meiotic cell cycle processGO:190304630.013
regulation of reproductive processGO:200024140.013
regulation of protein ubiquitinationGO:003139630.013
response to carbohydrateGO:000974330.013
protein homooligomerizationGO:005126030.013
positive regulation of striated muscle tissue developmentGO:004584410.013
apoptotic process involved in developmentGO:190274220.013
response to hexoseGO:000974630.013
positive regulation of protein complex assemblyGO:003133420.013
protein polyubiquitinationGO:000020940.013
negative regulation of protein complex assemblyGO:003133310.013
cell substrate junction assemblyGO:000704420.013
monocarboxylic acid catabolic processGO:007232930.013
positive regulation of epithelial cell proliferationGO:005067910.013
sequestering of calcium ionGO:005120830.013
regulation of dendrite morphogenesisGO:004881430.013
regulation of tube sizeGO:003515020.013
organelle organizationGO:00069962270.013
negative regulation of mitosisGO:004583930.013
regulation of mitochondrion organizationGO:001082110.013
melanin metabolic processGO:000658220.013
skeletal system developmentGO:00015011810.013
macromolecule modificationGO:00434121110.013
response to vitaminGO:003327330.013
purine nucleoside monophosphate catabolic processGO:000912840.013
positive regulation of notch signaling pathwayGO:004574730.013
developmental growthGO:00485891660.013
catecholamine metabolic processGO:000658420.013
regulation of microtubule cytoskeleton organizationGO:007050730.013
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.013
post embryonic organ developmentGO:004856940.013
carbohydrate homeostasisGO:003350010.012
hepaticobiliary system developmentGO:0061008980.012
androgen metabolic processGO:000820920.012
embryonic organ morphogenesisGO:00485622740.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
cell motilityGO:00488702440.012
positive regulation of neuron apoptotic processGO:004352510.012
single organism organelle organizationGO:19025891990.012
locomotionGO:00400113130.012
regulation of i kappab kinase nf kappab signalingGO:004312240.012
cytokinesisGO:000091030.012
regulation of glucose importGO:004632410.012
production of molecular mediator of immune responseGO:000244020.012
negative regulation of metabolic processGO:0009892860.012
er nucleus signaling pathwayGO:000698420.012
endocrine hormone secretionGO:006098620.012
neuron developmentGO:00486662620.012
pyruvate metabolic processGO:000609010.012
canonical wnt signaling pathwayGO:0060070480.012
xenobiotic metabolic processGO:000680540.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.012
protein localization to plasma membraneGO:007265910.012
sulfur compound transportGO:007234830.012
inorganic anion transportGO:0015698250.012
energy reserve metabolic processGO:000611220.012
positive regulation of dna metabolic processGO:005105410.012
negative regulation of small gtpase mediated signal transductionGO:005105810.012
phosphate containing compound metabolic processGO:00067961080.012
regulation of transmembrane transporter activityGO:002289820.012
ubiquitin dependent protein catabolic processGO:000651130.012
positive regulation of cellular metabolic processGO:0031325940.012
angiogenesisGO:00015251580.012
hypothalamus cell differentiationGO:002197940.012
positive regulation of histone modificationGO:003105810.012
dorsal ventral pattern formationGO:00099531250.012
peptide transportGO:001583310.012
female gonad developmentGO:000858540.012
oxalate transportGO:001953210.012
embryo development ending in birth or egg hatchingGO:00097922710.012
regulation of cell projection assemblyGO:006049140.012
regulation of protein metabolic processGO:0051246560.012
bicarbonate transportGO:001570140.012
negative regulation of intracellular transportGO:003238730.012
primitive hemopoiesisGO:0060215270.012
regulation of localizationGO:00328791040.012
cellular biogenic amine metabolic processGO:000657620.012
bmp signaling pathwayGO:0030509520.012
regulation of organelle assemblyGO:190211540.012
positive regulation of cellular catabolic processGO:003133130.011
heart morphogenesisGO:00030071560.011
behaviorGO:0007610740.011
i kappab kinase nf kappab signalingGO:000724940.011
toxin metabolic processGO:000940410.011
entrainment of circadian clock by photoperiodGO:004315310.011
negative regulation of kinase activityGO:003367340.011
regulation of production of molecular mediator of immune responseGO:000270010.011
negative regulation of neuron projection regenerationGO:007057140.011
cell agingGO:000756920.011
regulation of reactive oxygen species metabolic processGO:200037720.011
regulation of transporter activityGO:003240920.011
chemosensory behaviorGO:000763510.011
negative regulation of stem cell differentiationGO:200073720.011
regulation of translational initiationGO:000644610.011
gtp catabolic processGO:000618420.011
regulation of lipid transportGO:003236840.011
regulation of intracellular phGO:005145310.011
alcohol biosynthetic processGO:004616520.011
negative regulation of cellular catabolic processGO:003133030.011
response to oxygen containing compoundGO:1901700550.011
positive regulation of neuron deathGO:190121610.011
response to xenobiotic stimulusGO:0009410450.011
regulation of wound healingGO:006104120.011
regulation of transcription from rna polymerase ii promoterGO:00063571140.011
positive regulation of i kappab kinase nf kappab signalingGO:004312330.011
regulation of cytoplasmic transportGO:190364940.011
peptidyl threonine phosphorylationGO:001810710.011
spindle assemblyGO:005122520.011
positive regulation of endothelial cell proliferationGO:000193810.011
development of primary female sexual characteristicsGO:004654540.011
regulation of skeletal muscle tissue developmentGO:004864140.011
lipid catabolic processGO:001604240.011
regulation of response to oxidative stressGO:190288220.011
regulation of receptor mediated endocytosisGO:004825940.011
regulation of response to extracellular stimulusGO:003210410.011
membrane invaginationGO:001032410.011
rhombomere 5 developmentGO:002157140.011
regulation of protein polymerizationGO:003227120.011
protein complex localizationGO:003150310.011
positive regulation of nucleoside metabolic processGO:004597910.011
regulation of synaptic plasticityGO:004816710.011
response to oxygen levelsGO:0070482250.011
neurological system processGO:0050877620.011
regulation of blood pressureGO:000821710.011
adherens junction organizationGO:003433240.011
negative regulation of response to cytokine stimulusGO:006076120.011
regulation of bmp signaling pathwayGO:0030510390.011
negative regulation of protein transportGO:005122430.011
single organism cellular localizationGO:1902580460.011
membrane lipid biosynthetic processGO:004646720.011
protein heterooligomerizationGO:005129110.011
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.011
photoreceptor cell differentiationGO:0046530550.011
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.011
regulation of cellular response to oxidative stressGO:190040720.011
liver developmentGO:0001889960.011
negative regulation of multicellular organismal processGO:0051241690.010

pdk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:65500.032
disease of metabolismDOID:001466700.032
disease of anatomical entityDOID:700.029
organ system cancerDOID:005068600.023
disease of cellular proliferationDOID:1456600.023
cancerDOID:16200.023
nervous system diseaseDOID:86300.018
musculoskeletal system diseaseDOID:1700.014
sensory system diseaseDOID:005015500.013