Danio rerio

0 known processes

spra

sepiapterin reductase a

(Aliases: wu:fj86h06,zgc:112298,spr,fj86h06)

spra biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
pigmentationGO:0043473850.169
cellular pigmentationGO:0033059300.127
developmental pigmentationGO:0048066480.119
pigment cell differentiationGO:0050931380.104
aromatic compound biosynthetic processGO:00194382170.104
camera type eye developmentGO:00430102220.100
sensory organ developmentGO:00074233930.099
melanocyte differentiationGO:0030318260.087
chordate embryonic developmentGO:00430092710.085
negative regulation of cellular processGO:00485232830.084
cellular macromolecule metabolic processGO:00442603910.083
organic substance biosynthetic processGO:19015762890.080
regulation of cellular macromolecule biosynthetic processGO:20001122220.079
cellular macromolecule biosynthetic processGO:00346452240.077
larval developmentGO:000216420.075
regulation of multicellular organismal processGO:00512392770.073
nitrogen compound metabolic processGO:00068073190.071
cellular nitrogen compound metabolic processGO:00346412900.071
organic cyclic compound metabolic processGO:19013603010.068
biosynthetic processGO:00090582940.066
wnt signaling pathwayGO:0016055800.062
cellular aromatic compound metabolic processGO:00067252950.062
organic cyclic compound biosynthetic processGO:19013622230.062
regulation of nitrogen compound metabolic processGO:00511712510.061
generation of neuronsGO:00486993850.061
tissue remodelingGO:004877140.060
cell fate commitmentGO:0045165990.059
regulation of stem cell proliferationGO:007209120.059
regulation of primary metabolic processGO:00800903110.058
agingGO:000756820.057
nucleobase containing compound biosynthetic processGO:00346542050.055
regulation of macromolecule biosynthetic processGO:00105562250.055
regulation of nucleobase containing compound metabolic processGO:00192192500.055
brain developmentGO:00074202930.054
positive regulation of biological processGO:00485182530.054
nucleobase containing compound metabolic processGO:00061392740.050
macromolecule biosynthetic processGO:00090592270.050
cellular component morphogenesisGO:00329893360.048
neuroepithelial cell differentiationGO:0060563260.047
regulation of establishment of protein localizationGO:007020140.047
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.046
hemopoiesisGO:00300971830.045
morphogenesis of an epitheliumGO:00020093330.045
organelle organizationGO:00069962270.045
nucleic acid metabolic processGO:00903042440.044
regulation of multicellular organism growthGO:004001440.044
urogenital system developmentGO:0001655970.043
hematopoietic or lymphoid organ developmentGO:00485341910.043
epithelial cell differentiationGO:00308551160.043
cell morphogenesis involved in differentiationGO:00009041950.043
heterocycle biosynthetic processGO:00181302150.042
rna biosynthetic processGO:00327741810.041
neuron differentiationGO:00301823530.041
regulation of protein transportGO:005122330.041
rna metabolic processGO:00160702190.041
maintenance of locationGO:005123540.041
response to drugGO:004249330.040
transcription dna templatedGO:00063511810.040
gene expressionGO:00104672520.040
immune system processGO:00023762410.040
retina development in camera type eyeGO:00600411460.040
amine metabolic processGO:000930820.040
phosphatidylinositol 3 kinase signalingGO:001406520.039
cellular biosynthetic processGO:00442492860.039
embryonic organ developmentGO:00485683810.038
positive regulation of cell cycleGO:004578730.038
regulation of macromolecule metabolic processGO:00602553170.038
regulation of cellular biosynthetic processGO:00313262450.037
secondary metabolic processGO:001974830.036
regulation of epithelial cell proliferationGO:005067830.036
regulation of rna biosynthetic processGO:20011412130.036
oxoacid metabolic processGO:0043436310.035
regulation of transcription dna templatedGO:00063552130.035
regulation of biosynthetic processGO:00098892500.035
establishment of protein localization to organelleGO:007259440.034
regulation of rna metabolic processGO:00512522240.034
carboxylic acid metabolic processGO:0019752220.034
negative regulation of protein kinase activityGO:000646940.034
stem cell proliferationGO:007208940.034
cellular amine metabolic processGO:004410620.034
columnar cuboidal epithelial cell differentiationGO:0002065380.033
single organism organelle organizationGO:19025891990.033
regulation of bindingGO:005109830.033
positive regulation of cellular catabolic processGO:003133130.033
regulation of cellular amine metabolic processGO:003323800.033
positive regulation of catabolic processGO:000989640.032
eye developmentGO:00016542770.032
cell morphogenesisGO:00009022890.032
regulation of cellular metabolic processGO:00313233200.032
mitochondrion organizationGO:000700540.032
lipid storageGO:001991510.031
positive regulation of transportGO:005105020.031
regulation of gene expressionGO:00104682650.031
positive regulation of stress activated mapk cascadeGO:003287430.031
heterocycle metabolic processGO:00464832900.030
stem cell maintenanceGO:001982740.030
positive regulation of epithelial cell proliferationGO:005067910.030
nucleic acid templated transcriptionGO:00976591810.030
negative regulation of biological processGO:00485193040.030
extrinsic apoptotic signaling pathwayGO:009719130.029
single organism metabolic processGO:00447102170.029
sensory organ morphogenesisGO:00905962000.029
digestive system developmentGO:00551232890.029
organonitrogen compound metabolic processGO:1901564740.029
ear developmentGO:00435831270.029
cell migrationGO:00164772370.028
regulation of multicellular organismal developmentGO:20000262230.028
protein localization to nucleusGO:003450430.028
protein targeting to nucleusGO:004474430.028
embryonic organ morphogenesisGO:00485622740.028
pigment granule organizationGO:004875340.027
head developmentGO:00603223030.027
adult behaviorGO:003053420.027
germ line stem cell maintenanceGO:003071820.027
cell substrate adhesionGO:003158940.027
skeletal system morphogenesisGO:00487051020.027
organic acid metabolic processGO:0006082310.027
immune system developmentGO:00025201910.027
regulation of cellular amino acid metabolic processGO:000652100.027
myeloid cell differentiationGO:0030099860.027
mesenchymal cell developmentGO:0014031780.026
cellular response to external stimulusGO:007149620.026
central nervous system developmentGO:00074173870.026
single organism localizationGO:19025782250.026
phenol containing compound biosynthetic processGO:004618940.026
cell surface receptor signaling pathwayGO:00071663250.026
regulation of metabolic processGO:00192223590.026
multicellular organism growthGO:003526440.026
response to nutrientGO:000758430.025
response to carbohydrateGO:000974330.025
positive regulation of gene expressionGO:0010628710.025
small molecule metabolic processGO:0044281770.025
vasculature developmentGO:00019442780.025
regulation of nucleic acid templated transcriptionGO:19035062130.025
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.025
positive regulation of nitrogen compound metabolic processGO:0051173690.024
phagocytosisGO:000690930.024
mesenchyme developmentGO:00604851270.024
tube morphogenesisGO:00352393490.024
regulation of purine nucleotide catabolic processGO:003312120.024
cell part morphogenesisGO:00329902460.023
g1 s transition of mitotic cell cycleGO:000008210.023
regulation of cellular ketone metabolic processGO:001056570.023
regulation of cell shapeGO:000836010.023
cell projection morphogenesisGO:00488582440.023
positive regulation of cellular processGO:00485222010.023
regulation of synapse organizationGO:005080730.023
negative regulation of protein phosphorylationGO:000193340.023
striated muscle cell differentiationGO:00511461290.023
guanosine containing compound catabolic processGO:190106920.023
developmental growthGO:00485891660.023
single organism nuclear importGO:190259330.023
response to external stimulusGO:00096052640.023
transportGO:00068102200.022
apoptotic processGO:00069151160.022
erk1 and erk2 cascadeGO:007037140.022
cell projection organizationGO:00300302840.022
signal transduction in absence of ligandGO:003803410.022
positive regulation of nucleoside metabolic processGO:004597910.022
regulation of peptidyl tyrosine phosphorylationGO:005073010.022
deathGO:00162651210.022
regulation of protein localization to nucleusGO:190018020.022
positive regulation of transcription dna templatedGO:0045893570.022
protein importGO:001703830.022
guanosine containing compound metabolic processGO:190106840.022
gtp metabolic processGO:004603940.022
protein secretionGO:000930610.022
cellular protein catabolic processGO:004425740.022
digestive tract developmentGO:00485652650.022
nucleocytoplasmic transportGO:000691340.021
stem cell differentiationGO:00488631170.021
positive regulation of apoptotic signaling pathwayGO:200123510.021
regulation of cell deathGO:00109411030.021
positive regulation of cellular amine metabolic processGO:003324000.021
transmembrane transportGO:00550851200.021
canonical wnt signaling pathwayGO:0060070480.021
regulation of cytoplasmic transportGO:190364940.021
regulation of neural precursor cell proliferationGO:200017730.021
skeletal system developmentGO:00015011810.021
positive regulation of cellular component biogenesisGO:004408930.021
blood vessel developmentGO:00015682460.020
muscle organ developmentGO:00075171010.020
neuron projection morphogenesisGO:00488121610.020
proteasomal protein catabolic processGO:001049820.020
regulation of metal ion transportGO:001095940.020
cellular amino acid metabolic processGO:000652070.020
compound eye developmentGO:004874920.020
cellular component movementGO:00069283350.020
negative regulation of catabolic processGO:000989530.020
proteolysis involved in cellular protein catabolic processGO:005160330.020
regulation of protein catabolic processGO:004217610.020
muscle structure developmentGO:00610611960.020
positive regulation of neuron apoptotic processGO:004352510.020
cell morphogenesis involved in neuron differentiationGO:00486671630.020
modification dependent protein catabolic processGO:001994130.020
regulation of intracellular protein transportGO:003315730.020
digestive tract morphogenesisGO:00485462310.020
nucleoside monophosphate catabolic processGO:000912540.020
ribonucleoside monophosphate catabolic processGO:000915840.020
cellular component assembly involved in morphogenesisGO:00109271070.020
positive regulation of gtpase activityGO:004354710.020
regulation of protein bindingGO:004339330.020
symbiosis encompassing mutualism through parasitismGO:004440340.020
single organism transportGO:00447652060.019
inner ear developmentGO:00488391260.019
adherens junction organizationGO:003433240.019
pigment granule localizationGO:0051875250.019
regulation of cell activationGO:005086510.019
cell cycle g1 s phase transitionGO:004484310.019
alpha amino acid metabolic processGO:190160530.019
cellular ketone metabolic processGO:0042180110.019
catecholamine biosynthetic processGO:004242320.019
myeloid leukocyte differentiationGO:0002573150.019
modification dependent macromolecule catabolic processGO:004363230.019
response to chemicalGO:00422213200.019
transcription from rna polymerase ii promoterGO:0006366800.019
cell matrix adhesionGO:000716040.019
regulation of extrinsic apoptotic signaling pathwayGO:200123630.019
positive regulation of rna metabolic processGO:0051254590.019
neural crest cell differentiationGO:0014033720.019
regulation of reproductive processGO:200024140.019
ameboidal type cell migrationGO:00016671430.019
positive regulation of macromolecule biosynthetic processGO:0010557590.019
multi organism cellular processGO:004476420.018
purine ribonucleoside monophosphate catabolic processGO:000916940.018
establishment of localizationGO:00512342440.018
protein import into nucleusGO:000660630.018
skeletal muscle organ developmentGO:0060538780.018
positive regulation of purine nucleotide catabolic processGO:003312310.018
nuclear transportGO:005116940.018
gtp catabolic processGO:000618420.018
regulation of gtp catabolic processGO:003312420.018
positive regulation of map kinase activityGO:004340630.018
regulation of signalingGO:00230512350.018
regulation of wound healingGO:006104120.018
positive regulation of gtp catabolic processGO:003312610.018
melanin metabolic processGO:000658220.018
response to alkaloidGO:004327920.018
growthGO:00400071740.018
wound healingGO:0042060900.018
positive regulation of dna metabolic processGO:005105410.018
regulation of cytokine productionGO:000181730.017
regulation of synapse assemblyGO:005196330.017
cellular nitrogen compound biosynthetic processGO:00442712180.017
protein metabolic processGO:00195381830.017
regulation of erk1 and erk2 cascadeGO:007037240.017
positive regulation of cellular biosynthetic processGO:0031328680.017
regulation of protein import into nucleusGO:004230620.017
regulation of signal transductionGO:00099662250.017
phosphatidylinositol mediated signalingGO:004801520.017
interspecies interaction between organismsGO:004441940.017
negative regulation of kinase activityGO:003367340.017
nuclear importGO:005117030.017
enzyme linked receptor protein signaling pathwayGO:00071671060.017
cellular response to nutrient levelsGO:003166920.017
response to uvGO:000941130.017
chemosensory behaviorGO:000763510.017
localization of cellGO:00516742440.017
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.017
regulation of nucleoside metabolic processGO:000911820.017
ubiquitin dependent protein catabolic processGO:000651130.017
locomotor rhythmGO:004547530.017
protein acylationGO:004354330.017
skeletal muscle tissue developmentGO:0007519670.017
synaptic growth at neuromuscular junctionGO:005112420.017
autophagyGO:000691440.017
camera type eye morphogenesisGO:00485931080.017
positive regulation of jnk cascadeGO:004633030.017
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.016
positive regulation of nucleobase containing compound metabolic processGO:0045935690.016
negative regulation of map kinase activityGO:004340720.016
striated muscle tissue developmentGO:00147061100.016
leukocyte differentiationGO:0002521250.016
cognitionGO:005089010.016
negative regulation of programmed cell deathGO:0043069580.016
negative regulation of cellular catabolic processGO:003133030.016
b cell activationGO:004211320.016
regulation of programmed cell deathGO:00430671010.016
regulation of autophagyGO:001050630.016
regulation of nucleocytoplasmic transportGO:004682220.016
positive regulation of cellular amino acid metabolic processGO:004576400.016
positive regulation of rna biosynthetic processGO:1902680570.016
signal transductionGO:00071654550.016
regulation of gtpase activityGO:004308720.016
negative regulation of biosynthetic processGO:0009890550.016
inositol lipid mediated signalingGO:004801720.016
regulation of sequestering of calcium ionGO:005128240.016
positive regulation of secretion by cellGO:190353210.016
positive regulation of stem cell proliferationGO:200064810.016
somatic muscle developmentGO:000752540.016
osteoclast differentiationGO:003031610.016
dopamine metabolic processGO:004241720.016
cell proliferationGO:0008283800.016
cilium organizationGO:0044782710.015
cell cycle arrestGO:000705010.015
catechol containing compound metabolic processGO:000971220.015
positive regulation of secretionGO:005104710.015
neural crest cell developmentGO:0014032620.015
ear morphogenesisGO:0042471640.015
regulation of apoptotic processGO:0042981980.015
positive regulation of nucleotide catabolic processGO:003081310.015
negative regulation of protein serine threonine kinase activityGO:007190120.015
regulation of cell differentiationGO:00455951420.015
convergent extensionGO:00600261180.015
positive regulation of wound healingGO:009030310.015
negative regulation of mapk cascadeGO:004340940.015
regulation of cell substrate adhesionGO:001081010.015
purine nucleoside monophosphate catabolic processGO:000912840.015
regulation of protein targetingGO:190353320.015
positive regulation of erk1 and erk2 cascadeGO:007037420.015
embryonic skeletal system morphogenesisGO:0048704930.015
single organism membrane fusionGO:004480120.015
regulation of meiotic cell cycleGO:005144510.015
alcohol biosynthetic processGO:004616520.015
regulation of calcium ion transportGO:005192420.015
positive regulation of nucleic acid templated transcriptionGO:1903508570.015
negative regulation of cell deathGO:0060548600.015
production of molecular mediator of immune responseGO:000244020.015
stem cell developmentGO:0048864820.015
female sex differentiationGO:004666040.015
glucose importGO:004632320.015
cellular localizationGO:0051641970.015
regulation of synaptic growth at neuromuscular junctionGO:000858210.015
lymphocyte proliferationGO:004665110.014
peripheral nervous system developmentGO:0007422550.014
positive regulation of cytoskeleton organizationGO:005149530.014
endosomal transportGO:001619720.014
blood vessel morphogenesisGO:00485142160.014
cilium morphogenesisGO:0060271850.014
cellular lipid metabolic processGO:0044255360.014
atp catabolic processGO:000620040.014
developmental programmed cell deathGO:001062340.014
meiotic nuclear divisionGO:000712640.014
negative regulation of metabolic processGO:0009892860.014
regulation of protein complex assemblyGO:004325430.014
positive regulation of cytokine productionGO:000181920.014
cellular component assemblyGO:00226071700.014
regulation of developmental processGO:00507932470.014
mesenchymal cell differentiationGO:0048762870.014
locomotionGO:00400113130.014
negative regulation of intracellular transportGO:003238730.014
cartilage developmentGO:0051216960.014
negative regulation of cytoplasmic transportGO:190365020.014
peptidyl serine phosphorylationGO:001810510.014
somatic stem cell maintenanceGO:003501910.014
lipid catabolic processGO:001604240.014
viral processGO:001603210.014
response to glucoseGO:000974930.013
regulation of nucleotide catabolic processGO:003081120.013
protein stabilizationGO:005082120.013
positive regulation of canonical wnt signaling pathwayGO:009026340.013
eye morphogenesisGO:00485921440.013
negative regulation of cellular metabolic processGO:0031324770.013
exocytosisGO:000688710.013
organic substance transportGO:0071702580.013
response to woundingGO:00096111160.013
negative regulation of cytokine productionGO:000181810.013
regulation of tube sizeGO:003515020.013
regulation of protein modification by small protein conjugation or removalGO:190332030.013
action potentialGO:0001508190.013
mitotic cell cycleGO:0000278640.013
positive regulation of multicellular organismal processGO:0051240520.013
positive regulation of cell adhesionGO:004578510.013
meiotic cell cycle processGO:190304630.013
embryo development ending in birth or egg hatchingGO:00097922710.013
axon developmentGO:00615641660.013
apoptotic process involved in developmentGO:190274220.013
organelle assemblyGO:00709251100.013
regulation of glucose transportGO:001082710.013
specification of symmetryGO:00097992040.013
cilium assemblyGO:0042384580.013
negative regulation of nitrogen compound metabolic processGO:0051172590.013
cellular response to extracellular stimulusGO:003166820.013
cellular component disassemblyGO:002241110.013
regulation of cell developmentGO:00602841000.013
multicellular organismal signalingGO:0035637220.013
response to other organismGO:0051707970.013
post embryonic organ developmentGO:004856940.013
peptidyl lysine acetylationGO:001839420.013
cellular response to molecule of bacterial originGO:007121930.013
positive regulation of jak stat cascadeGO:004642720.013
melanosome localizationGO:0032400210.013
regulation of stem cell differentiationGO:200073640.013
intracellular signal transductionGO:0035556850.012
actin filament based movementGO:003004810.012
peptidyl serine modificationGO:001820920.012
heart developmentGO:00075073130.012
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.012
protein acetylationGO:000647320.012
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.012
anterior posterior pattern specificationGO:00099521520.012
negative regulation of protein transportGO:005122430.012
cell deathGO:00082191210.012
membrane fusionGO:006102520.012
cellular response to chemical stimulusGO:00708871570.012
catecholamine metabolic processGO:000658420.012
positive regulation of chromosome organizationGO:200125210.012
response to monosaccharideGO:003428430.012
epithelial tube morphogenesisGO:00605621480.012
negative regulation of gene expressionGO:0010629650.012
inner ear morphogenesisGO:0042472630.012
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.012
peptidyl threonine phosphorylationGO:001810710.012
system processGO:00030081850.012
negative regulation of epithelial cell proliferationGO:005068010.012
monocyte differentiationGO:003022420.012
regulation of mrna processingGO:005068430.012
negative regulation of cellular biosynthetic processGO:0031327550.012
protein homooligomerizationGO:005126030.012
small molecule catabolic processGO:004428230.012
ovulation cycleGO:004269820.012
establishment of localization in cellGO:0051649770.012
bone remodelingGO:004684920.012
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.012
muscle tissue developmentGO:00605371100.012
axonogenesisGO:00074091520.012
spermatid differentiationGO:004851520.012
regulation of glucose importGO:004632410.012
regulation of rho protein signal transductionGO:003502320.012
dorsal ventral pattern formationGO:00099531250.011
negative regulation of leukocyte differentiationGO:190210610.011
regulation of biological qualityGO:00650082630.011
regulation of response to stimulusGO:00485832690.011
negative regulation of immune responseGO:005077720.011
nephron tubule morphogenesisGO:007207810.011
embryonic limb morphogenesisGO:003032620.011
organelle fusionGO:004828430.011
renal system developmentGO:0072001940.011
internal protein amino acid acetylationGO:000647520.011
response to organic substanceGO:00100331530.011
peptidyl threonine modificationGO:001821010.011
response to hexoseGO:000974630.011
mononuclear cell proliferationGO:003294310.011
taxisGO:00423301090.011
determination of bilateral symmetryGO:00098552040.011
cellular response to drugGO:003569010.011
response to stressGO:00069502630.011
negative regulation of signal transductionGO:0009968940.011
development of primary female sexual characteristicsGO:004654540.011
positive regulation of protein complex assemblyGO:003133420.011
leukocyte proliferationGO:007066110.011
ovulation cycle processGO:002260220.011
regulation of hormone secretionGO:004688320.011
positive regulation of neuron deathGO:190121610.011
negative regulation of protein localization to nucleusGO:190018120.011
gland developmentGO:00487321430.011
amino acid transportGO:000686520.011
embryonic skeletal joint developmentGO:007249830.011
cellular response to starvationGO:000926710.011
nephron morphogenesisGO:007202820.011
negative regulation of apoptotic processGO:0043066550.011
response to corticosteroidGO:003196010.011
cellular response to biotic stimulusGO:007121630.011
forebrain cell migrationGO:002188510.011
positive regulation of cell divisionGO:005178120.011
b cell differentiationGO:003018310.011
regulation of oocyte developmentGO:006028130.011
negative regulation of ras protein signal transductionGO:004658010.011
neuronal action potentialGO:0019228180.011
negative regulation of macromolecule metabolic processGO:0010605760.011
phosphorylationGO:0016310690.011
regulation of membrane potentialGO:0042391230.011
regulation of wnt signaling pathwayGO:0030111530.011
catechol containing compound biosynthetic processGO:000971320.011
forebrain regionalizationGO:002187140.011
developmental growth involved in morphogenesisGO:0060560860.011
embryonic skeletal system developmentGO:0048706970.011
connective tissue developmentGO:0061448990.010
negative regulation of reproductive processGO:200024230.010
protein complex biogenesisGO:0070271300.010
regulation of i kappab kinase nf kappab signalingGO:004312240.010
fatty acid oxidationGO:001939510.010
neuron neuron synaptic transmissionGO:000727010.010
ras protein signal transductionGO:000726570.010
regulation of production of molecular mediator of immune responseGO:000270010.010
kupffer s vesicle developmentGO:0070121500.010
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.010
tube closureGO:006060610.010
neuromuscular synaptic transmissionGO:000727420.010
dopamine biosynthetic processGO:004241620.010
kidney developmentGO:0001822920.010

spra disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.058
cancerDOID:16200.058
disease of anatomical entityDOID:700.039
organ system cancerDOID:005068600.031
musculoskeletal system diseaseDOID:1700.017
nervous system diseaseDOID:86300.014
immune system diseaseDOID:291400.014
sensory system diseaseDOID:005015500.013
eye and adnexa diseaseDOID:149200.013
retinal diseaseDOID:567900.013
eye diseaseDOID:561400.013
disease of metabolismDOID:001466700.013
connective tissue diseaseDOID:6500.012
bone diseaseDOID:008000100.012