IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

hbbe2

hemoglobin beta embryonic-2

ZFIN: ZDB-GENE-040702-1
Entrez: 405772
Ensembl: ENSDARG00000045143
UniProtKB: Q7T1B0

Process Predictions
Disease Predictions

hbbe2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
primitive erythrocyte differentiation	GO:0060319	5	0.976
erythrocyte homeostasis	GO:0034101	55	0.744	Mouse
regulation of metabolic process	GO:0019222	359	0.600	Mouse
hematopoietic or lymphoid organ development	GO:0048534	191	0.517	Mouse
erythrocyte differentiation	GO:0030218	54	0.497	Mouse
erythrocyte development	GO:0048821	24	0.467	Mouse
erythrocyte maturation	GO:0043249	8	0.461
larval development	GO:0002164	2	0.414
primitive hemopoiesis	GO:0060215	27	0.267
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.220	Mouse
embryonic hemopoiesis	GO:0035162	53	0.202
immune system process	GO:0002376	241	0.179	Mouse
nucleic acid metabolic process	GO:0090304	244	0.163	Mouse
organonitrogen compound metabolic process	GO:1901564	74	0.159	Rat
negative regulation of biological process	GO:0048519	304	0.158	Mouse
homeostasis of number of cells	GO:0048872	62	0.155	Mouse
regulation of biological quality	GO:0065008	263	0.147	Mouse
aromatic compound biosynthetic process	GO:0019438	217	0.138	Mouse
cofactor biosynthetic process	GO:0051188	10	0.137
cellular component assembly	GO:0022607	170	0.136	Rat
cellular nitrogen compound metabolic process	GO:0034641	290	0.127	Mouse Rat
positive regulation of biological process	GO:0048518	253	0.120
aging	GO:0007568	2	0.119
negative regulation of embryonic development	GO:0045992	11	0.117
tetrapyrrole biosynthetic process	GO:0033014	8	0.114
negative regulation of gene expression	GO:0010629	65	0.114	Mouse
response to drug	GO:0042493	3	0.113
lipid storage	GO:0019915	1	0.111
muscle structure development	GO:0061061	196	0.109
rna biosynthetic process	GO:0032774	181	0.100	Mouse
regulation of embryonic development	GO:0045995	47	0.098
protein metabolic process	GO:0019538	183	0.097	Mouse
heme metabolic process	GO:0042168	9	0.096
heterocycle metabolic process	GO:0046483	290	0.095	Mouse
signal transduction	GO:0007165	455	0.095
cellular macromolecule metabolic process	GO:0044260	391	0.095	Mouse
cellular aromatic compound metabolic process	GO:0006725	295	0.093	Mouse
maintenance of location	GO:0051235	4	0.092
response to chemical	GO:0042221	320	0.089
embryonic organ development	GO:0048568	381	0.089
myeloid cell homeostasis	GO:0002262	56	0.084	Mouse
cell surface receptor signaling pathway	GO:0007166	325	0.081
circulatory system process	GO:0003013	87	0.075
regulation of cellular biosynthetic process	GO:0031326	245	0.072	Mouse
regulation of gene expression	GO:0010468	265	0.071	Mouse
immune system development	GO:0002520	191	0.068	Mouse
organic cyclic compound biosynthetic process	GO:1901362	223	0.067	Mouse
cellular biosynthetic process	GO:0044249	286	0.067	Mouse
gas transport	GO:0015669	3	0.066	Mouse Rat
heart development	GO:0007507	313	0.066
nitrogen compound metabolic process	GO:0006807	319	0.065	Mouse Rat
cellular iron ion homeostasis	GO:0006879	3	0.062
cellular component movement	GO:0006928	335	0.061
nucleic acid templated transcription	GO:0097659	181	0.061	Mouse
cell morphogenesis	GO:0000902	289	0.060
hatching gland development	GO:0048785	3	0.059
nucleobase containing compound metabolic process	GO:0006139	274	0.058	Mouse
sodium ion transmembrane transport	GO:0035725	21	0.055
regulation of translational initiation	GO:0006446	1	0.054	Mouse
regulation of intracellular protein transport	GO:0033157	3	0.053
organic substance biosynthetic process	GO:1901576	289	0.053	Mouse
regulation of cell communication	GO:0010646	232	0.051
negative regulation of protein phosphorylation	GO:0001933	4	0.051
cellular macromolecule biosynthetic process	GO:0034645	224	0.051	Mouse
regulation of binding	GO:0051098	3	0.051
regulation of developmental process	GO:0050793	247	0.051
myeloid cell development	GO:0061515	32	0.050	Mouse
regulation of multicellular organismal process	GO:0051239	277	0.049
protein targeting to nucleus	GO:0044744	3	0.049
phosphorus metabolic process	GO:0006793	109	0.048	Mouse
central nervous system development	GO:0007417	387	0.046
homeostatic process	GO:0042592	142	0.045	Mouse
tetrapyrrole metabolic process	GO:0033013	10	0.045
cellular amide metabolic process	GO:0043603	4	0.044	Rat
negative regulation of cellular process	GO:0048523	283	0.044	Mouse
ectoderm formation	GO:0001705	2	0.044
regulation of macromolecule metabolic process	GO:0060255	317	0.044	Mouse
organonitrogen compound biosynthetic process	GO:1901566	47	0.041
pancreas development	GO:0031016	84	0.040
regulation of multicellular organismal development	GO:2000026	223	0.040
regulation of signaling	GO:0023051	235	0.040
regulation of response to stimulus	GO:0048583	269	0.040	Mouse
rna metabolic process	GO:0016070	219	0.040	Mouse
macromolecular complex assembly	GO:0065003	35	0.039	Rat
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	3	0.039
hemopoiesis	GO:0030097	183	0.038	Mouse
protein localization to nucleus	GO:0034504	3	0.038
cell morphogenesis involved in differentiation	GO:0000904	195	0.037
negative regulation of gastrulation	GO:2000542	11	0.036
response to external stimulus	GO:0009605	264	0.036
tube morphogenesis	GO:0035239	349	0.035
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.034	Mouse
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.033
regulation of cytokine production	GO:0001817	3	0.033
cellular response to chemical stimulus	GO:0070887	157	0.033
gene expression	GO:0010467	252	0.033	Mouse
myeloid cell differentiation	GO:0030099	86	0.032	Mouse
porphyrin containing compound biosynthetic process	GO:0006779	8	0.032
regulation of protein targeting	GO:1903533	2	0.032
regulation of cell death	GO:0010941	103	0.032
regulation of alternative mrna splicing via spliceosome	GO:0000381	1	0.031
protein heterooligomerization	GO:0051291	1	0.031	Rat
protein import	GO:0017038	3	0.031
regulation of locomotion	GO:0040012	55	0.030
positive regulation of cellular process	GO:0048522	201	0.030
liver development	GO:0001889	96	0.030
heme biosynthetic process	GO:0006783	8	0.029
extrinsic apoptotic signaling pathway	GO:0097191	3	0.029
cation transport	GO:0006812	81	0.029
regulation of reproductive process	GO:2000241	4	0.029
regulation of rna metabolic process	GO:0051252	224	0.029	Mouse
heart morphogenesis	GO:0003007	156	0.029
positive regulation of cell communication	GO:0010647	56	0.028
cellular component biogenesis	GO:0044085	178	0.028	Rat
hepaticobiliary system development	GO:0061008	98	0.028
organic cyclic compound metabolic process	GO:1901360	301	0.028	Mouse
negative regulation of macromolecule metabolic process	GO:0010605	76	0.027	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.027
mesodermal cell fate specification	GO:0007501	12	0.027
regulation of establishment of protein localization	GO:0070201	4	0.026
regulation of nitrogen compound metabolic process	GO:0051171	251	0.026	Mouse
regulation of primary metabolic process	GO:0080090	311	0.026	Mouse
regulation of intracellular signal transduction	GO:1902531	57	0.025
regulation of cellular metabolic process	GO:0031323	320	0.025	Mouse
biosynthetic process	GO:0009058	294	0.024	Mouse
outflow tract morphogenesis	GO:0003151	1	0.024
porphyrin containing compound metabolic process	GO:0006778	10	0.024
intracellular signal transduction	GO:0035556	85	0.024
positive regulation of transport	GO:0051050	2	0.024
stem cell proliferation	GO:0072089	4	0.023
establishment of protein localization to organelle	GO:0072594	4	0.023
regulation of protein binding	GO:0043393	3	0.023
cation homeostasis	GO:0055080	33	0.023
response to stress	GO:0006950	263	0.023	Mouse
regulation of ectodermal cell fate specification	GO:0042665	2	0.023
regulation of cell shape	GO:0008360	1	0.022
multi organism process	GO:0051704	134	0.022
regulation of molecular function	GO:0065009	70	0.022
negative regulation of cellular metabolic process	GO:0031324	77	0.022	Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.022	Mouse
regulation of transporter activity	GO:0032409	2	0.022
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.021
locomotion	GO:0040011	313	0.021
determination of bilateral symmetry	GO:0009855	204	0.021
protein import into nucleus	GO:0006606	3	0.021
cell projection morphogenesis	GO:0048858	244	0.021
regulation of mrna processing	GO:0050684	3	0.021
cellular component morphogenesis	GO:0032989	336	0.021
regulation of biosynthetic process	GO:0009889	250	0.021	Mouse
removal of superoxide radicals	GO:0019430	2	0.020
i kappab kinase nf kappab signaling	GO:0007249	4	0.020
reactive oxygen species biosynthetic process	GO:1903409	1	0.020
cytokinesis	GO:0000910	3	0.020
forebrain regionalization	GO:0021871	4	0.020
cytoskeleton dependent cytokinesis	GO:0061640	3	0.020
single organism localization	GO:1902578	225	0.020	Mouse Rat
mesodermal cell differentiation	GO:0048333	21	0.019
regulation of protein transport	GO:0051223	3	0.019
positive regulation of response to stimulus	GO:0048584	80	0.019
digestive system development	GO:0055123	289	0.019
negative regulation of multicellular organismal process	GO:0051241	69	0.018
regulation of erk1 and erk2 cascade	GO:0070372	4	0.018
system process	GO:0003008	185	0.018
nuclear transport	GO:0051169	4	0.018
female sex differentiation	GO:0046660	4	0.018
multicellular organism growth	GO:0035264	4	0.018
regulation of nucleocytoplasmic transport	GO:0046822	2	0.018
cellular response to external stimulus	GO:0071496	2	0.018
actin mediated cell contraction	GO:0070252	1	0.018
death	GO:0016265	121	0.017
positive regulation of signaling	GO:0023056	56	0.017
cellular homeostasis	GO:0019725	26	0.017
regulation of cytoplasmic transport	GO:1903649	4	0.017
ion homeostasis	GO:0050801	41	0.017
negative regulation of developmental process	GO:0051093	65	0.017
nuclear import	GO:0051170	3	0.017
cell motility	GO:0048870	244	0.017
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	2	0.017
regulation of protein localization to nucleus	GO:1900180	2	0.017
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.017
dopamine metabolic process	GO:0042417	2	0.017
kidney development	GO:0001822	92	0.017
negative regulation of protein complex assembly	GO:0031333	1	0.017
oxoacid metabolic process	GO:0043436	31	0.017	Rat
regulation of i kappab kinase nf kappab signaling	GO:0043122	4	0.017
actin filament based process	GO:0030029	64	0.016
carbon dioxide transport	GO:0015670	3	0.016
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	1	0.016
venous blood vessel morphogenesis	GO:0048845	3	0.016
macromolecule biosynthetic process	GO:0009059	227	0.016	Mouse
regulation of tube size	GO:0035150	2	0.016
gland development	GO:0048732	143	0.016
negative regulation of cell death	GO:0060548	60	0.016
cell substrate adhesion	GO:0031589	4	0.016
hatching	GO:0035188	4	0.016
brain development	GO:0007420	293	0.015
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.015	Mouse
neuron projection morphogenesis	GO:0048812	161	0.015
mitotic cytokinesis	GO:0000281	3	0.015
post embryonic organ development	GO:0048569	4	0.015
organic substance transport	GO:0071702	58	0.015
axonogenesis	GO:0007409	152	0.015
mesoderm development	GO:0007498	88	0.015
head development	GO:0060322	303	0.015
ectodermal cell fate specification	GO:0001715	2	0.015
cofactor metabolic process	GO:0051186	15	0.015
sodium ion transport	GO:0006814	24	0.015
cytoskeleton organization	GO:0007010	96	0.014
establishment of blood brain barrier	GO:0060856	2	0.014
regulation of protein import into nucleus	GO:0042306	2	0.014
endocrine process	GO:0050886	2	0.014
transmembrane transport	GO:0055085	120	0.014
optic nerve morphogenesis	GO:0021631	6	0.014
macromolecule modification	GO:0043412	111	0.014	Mouse
negative regulation of mesodermal cell fate specification	GO:0042662	3	0.014
peptidyl serine modification	GO:0018209	2	0.014
regulation of mrna splicing via spliceosome	GO:0048024	3	0.014
catechol containing compound metabolic process	GO:0009712	2	0.014
response to amine	GO:0014075	1	0.013
regulation of circadian rhythm	GO:0042752	4	0.013
cellular ketone metabolic process	GO:0042180	11	0.013
digestive tract development	GO:0048565	265	0.013
iron ion homeostasis	GO:0055072	4	0.013
catecholamine metabolic process	GO:0006584	2	0.013
regulation of erythrocyte differentiation	GO:0045646	2	0.013
translational initiation	GO:0006413	3	0.013
cellular cation homeostasis	GO:0030003	17	0.013
single organism metabolic process	GO:0044710	217	0.013	Mouse Rat
macromolecule localization	GO:0033036	54	0.013
cellular amine metabolic process	GO:0044106	2	0.013
amine metabolic process	GO:0009308	2	0.013
positive regulation of catabolic process	GO:0009896	4	0.013
mesoderm formation	GO:0001707	43	0.013
toxin transport	GO:1901998	2	0.013
neuron differentiation	GO:0030182	353	0.012
positive regulation of signal transduction	GO:0009967	56	0.012
apoptotic signaling pathway	GO:0097190	23	0.012
modification dependent protein catabolic process	GO:0019941	3	0.012
regulation of apoptotic process	GO:0042981	98	0.012
metal ion transport	GO:0030001	58	0.012
regulation of cell matrix adhesion	GO:0001952	1	0.012
bicarbonate transport	GO:0015701	4	0.012
wnt signaling pathway	GO:0016055	80	0.012
positive regulation of cytosolic calcium ion concentration	GO:0007204	4	0.012
morphogenesis of an epithelium	GO:0002009	333	0.012
cell volume homeostasis	GO:0006884	1	0.012
regulation of cellular amine metabolic process	GO:0033238	0	0.012
cellular response to superoxide	GO:0071451	2	0.012
cellular transition metal ion homeostasis	GO:0046916	3	0.012
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.012
synaptic growth at neuromuscular junction	GO:0051124	2	0.012
heterocycle biosynthetic process	GO:0018130	215	0.012	Mouse
regulation of protein complex assembly	GO:0043254	3	0.012
paraxial mesoderm morphogenesis	GO:0048340	2	0.011
cell death	GO:0008219	121	0.011
regulation of phosphorus metabolic process	GO:0051174	43	0.011	Mouse
regulation of production of molecular mediator of immune response	GO:0002700	1	0.011
apoptotic process	GO:0006915	116	0.011
cardiac atrium morphogenesis	GO:0003209	2	0.011
phagocytosis	GO:0006909	3	0.011
single organism nuclear import	GO:1902593	3	0.011
positive regulation of cellular catabolic process	GO:0031331	3	0.011
regulation of cellular component movement	GO:0051270	55	0.011
catecholamine biosynthetic process	GO:0042423	2	0.011
positive regulation of blood circulation	GO:1903524	2	0.011
axonal defasciculation	GO:0007414	2	0.011
positive regulation of cellular metabolic process	GO:0031325	94	0.011
localization of cell	GO:0051674	244	0.011
cardiac atrium development	GO:0003230	4	0.010
digestive tract morphogenesis	GO:0048546	231	0.010
positive regulation of cellular component biogenesis	GO:0044089	3	0.010
regulation of anatomical structure morphogenesis	GO:0022603	130	0.010
positive regulation of heart contraction	GO:0045823	2	0.010
negative regulation of metabolic process	GO:0009892	86	0.010	Mouse
cell migration	GO:0016477	237	0.010
ventricular cardiac muscle tissue development	GO:0003229	3	0.010
negative regulation of apoptotic process	GO:0043066	55	0.010
regulation of rna biosynthetic process	GO:2001141	213	0.010	Mouse
rna localization	GO:0006403	4	0.010
dopamine biosynthetic process	GO:0042416	2	0.010

hbbe2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.145
organ system cancer	DOID:0050686	0.038
cancer	DOID:162	0.038
disease of cellular proliferation	DOID:14566	0.038
immune system disease	DOID:2914	0.027
hematopoietic system disease	DOID:74	0.015
musculoskeletal system disease	DOID:17	0.015

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