IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

kars

lysyl-tRNA synthetase

(Aliases: cb530,wu:fa16h02,zgc:92483)

Entrez: 280647
ZFIN: ZDB-GENE-021115-8
Ensembl: ENSDARG00000044220
UniProtKB: Q6DHE6
UniProtKB: F1QSF6

Process Predictions
Disease Predictions

kars biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
biosynthetic process	GO:0009058	294	0.701	Human
larval development	GO:0002164	2	0.640	Worm
gene expression	GO:0010467	252	0.566	Human
cellular biosynthetic process	GO:0044249	286	0.539	Human
cellular macromolecule metabolic process	GO:0044260	391	0.524	Human
macromolecule biosynthetic process	GO:0009059	227	0.455	Human
regulation of macromolecule biosynthetic process	GO:0010556	225	0.443
nucleic acid metabolic process	GO:0090304	244	0.418	Human
cellular macromolecule biosynthetic process	GO:0034645	224	0.396	Human
regulation of macromolecule metabolic process	GO:0060255	317	0.387
regulation of gene expression	GO:0010468	265	0.344
positive regulation of biological process	GO:0048518	253	0.309	Worm
regulation of multicellular organismal process	GO:0051239	277	0.296	Worm
regulation of primary metabolic process	GO:0080090	311	0.294
protein metabolic process	GO:0019538	183	0.292	Human
head development	GO:0060322	303	0.263
translational initiation	GO:0006413	3	0.230
embryo development ending in birth or egg hatching	GO:0009792	271	0.202	Worm
organic substance biosynthetic process	GO:1901576	289	0.194	Human
locomotion	GO:0040011	313	0.181
heterocycle biosynthetic process	GO:0018130	215	0.174
regulation of biosynthetic process	GO:0009889	250	0.171
regulation of cellular metabolic process	GO:0031323	320	0.167
negative regulation of cellular process	GO:0048523	283	0.162
negative regulation of biological process	GO:0048519	304	0.157
central nervous system development	GO:0007417	387	0.138
regulation of metabolic process	GO:0019222	359	0.136
regulation of developmental process	GO:0050793	247	0.136	Worm
lipid storage	GO:0019915	1	0.129
cellular nitrogen compound metabolic process	GO:0034641	290	0.126	Human
aging	GO:0007568	2	0.125
small molecule metabolic process	GO:0044281	77	0.121	Human
transcription dna templated	GO:0006351	181	0.106
nitrogen compound metabolic process	GO:0006807	319	0.106	Human
regulation of translational initiation	GO:0006446	1	0.103
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.101
cell death	GO:0008219	121	0.097
organic cyclic compound biosynthetic process	GO:1901362	223	0.095
translation	GO:0006412	5	0.092	Human
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.092
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.089
regulation of cellular biosynthetic process	GO:0031326	245	0.078
cellular protein metabolic process	GO:0044267	129	0.077	Human
organic cyclic compound metabolic process	GO:1901360	301	0.077	Human
rna biosynthetic process	GO:0032774	181	0.075
rna metabolic process	GO:0016070	219	0.072	Human
cellular amino acid metabolic process	GO:0006520	7	0.071	Human
brain development	GO:0007420	293	0.071
regulation of multicellular organism growth	GO:0040014	4	0.063	Worm
multicellular organism growth	GO:0035264	4	0.059	Worm
regulation of proteolysis	GO:0030162	24	0.058
regulation of protein metabolic process	GO:0051246	56	0.057
ribosomal small subunit biogenesis	GO:0042274	2	0.055
single organism metabolic process	GO:0044710	217	0.055	Human
negative regulation of macromolecule metabolic process	GO:0010605	76	0.053
heterocycle metabolic process	GO:0046483	290	0.053	Human
regulation of cellular protein metabolic process	GO:0032268	52	0.053
embryonic organ development	GO:0048568	381	0.052
regulation of nucleic acid templated transcription	GO:1903506	213	0.050
reproduction	GO:0000003	40	0.048	Worm
regulation of programmed cell death	GO:0043067	101	0.048
regulation of apoptotic process	GO:0042981	98	0.048
regulation of biological quality	GO:0065008	263	0.045
transport	GO:0006810	220	0.045
nucleobase containing compound metabolic process	GO:0006139	274	0.043	Human
phosphorus metabolic process	GO:0006793	109	0.043
response to abiotic stimulus	GO:0009628	122	0.043
response to chemical	GO:0042221	320	0.043
aromatic compound biosynthetic process	GO:0019438	217	0.043
regulation of rna metabolic process	GO:0051252	224	0.042
cellular aromatic compound metabolic process	GO:0006725	295	0.041	Human
regulation of transcription dna templated	GO:0006355	213	0.039
maintenance of location	GO:0051235	4	0.039
apoptotic process	GO:0006915	116	0.036
cell morphogenesis	GO:0000902	289	0.035
positive regulation of translation	GO:0045727	1	0.034
nucleic acid templated transcription	GO:0097659	181	0.034
positive regulation of cellular biosynthetic process	GO:0031328	68	0.034
system process	GO:0003008	185	0.033
death	GO:0016265	121	0.033
response to other organism	GO:0051707	97	0.033
cellular amine metabolic process	GO:0044106	2	0.033
cellular component morphogenesis	GO:0032989	336	0.032
macromolecule modification	GO:0043412	111	0.032
establishment of localization	GO:0051234	244	0.031
organic acid metabolic process	GO:0006082	31	0.030	Human
embryonic skeletal system morphogenesis	GO:0048704	93	0.030
regulation of translation	GO:0006417	3	0.029
programmed cell death	GO:0012501	119	0.029
negative regulation of gene expression	GO:0010629	65	0.028
regulation of signal transduction	GO:0009966	225	0.028
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.027
eye development	GO:0001654	277	0.027
cell part morphogenesis	GO:0032990	246	0.026
positive regulation of cellular process	GO:0048522	201	0.026
response to external stimulus	GO:0009605	264	0.025
regulation of response to stimulus	GO:0048583	269	0.025
chordate embryonic development	GO:0043009	271	0.024
positive regulation of cellular metabolic process	GO:0031325	94	0.024
negative regulation of metabolic process	GO:0009892	86	0.024
negative regulation of cellular biosynthetic process	GO:0031327	55	0.024
protein modification process	GO:0036211	100	0.024
single organism localization	GO:1902578	225	0.023
neuron projection morphogenesis	GO:0048812	161	0.023
positive regulation of macromolecule metabolic process	GO:0010604	93	0.023
developmental growth	GO:0048589	166	0.023	Worm
positive regulation of gtpase activity	GO:0043547	1	0.022
regulation of anatomical structure morphogenesis	GO:0022603	130	0.022
positive regulation of transcription dna templated	GO:0045893	57	0.022
regulation of nucleoside metabolic process	GO:0009118	2	0.021
neuron differentiation	GO:0030182	353	0.021
negative regulation of apoptotic process	GO:0043066	55	0.021
oxoacid metabolic process	GO:0043436	31	0.021	Human
endocytosis	GO:0006897	16	0.021
single organism biosynthetic process	GO:0044711	71	0.021
camera type eye development	GO:0043010	222	0.021
signal transduction	GO:0007165	455	0.021
response to external biotic stimulus	GO:0043207	97	0.020
response to stress	GO:0006950	263	0.020
nucleoside monophosphate catabolic process	GO:0009125	4	0.020
positive regulation of metabolic process	GO:0009893	108	0.019
microtubule organizing center organization	GO:0031023	1	0.019
fin regeneration	GO:0031101	51	0.019
dna biosynthetic process	GO:0071897	3	0.019
maturation of ssu rrna	GO:0030490	1	0.019
embryonic skeletal system development	GO:0048706	97	0.019
cell projection morphogenesis	GO:0048858	244	0.018
cellular component disassembly	GO:0022411	1	0.018
negative regulation of biosynthetic process	GO:0009890	55	0.018
embryonic heart tube development	GO:0035050	133	0.018
cell migration	GO:0016477	237	0.018
transmembrane transport	GO:0055085	120	0.018
negative regulation of programmed cell death	GO:0043069	58	0.018
protein acetylation	GO:0006473	2	0.017
negative regulation of response to stimulus	GO:0048585	104	0.017
single organism organelle organization	GO:1902589	199	0.016
response to biotic stimulus	GO:0009607	97	0.016
phagocytosis	GO:0006909	3	0.015
embryonic organ morphogenesis	GO:0048562	274	0.015
amine metabolic process	GO:0009308	2	0.015
cell morphogenesis involved in differentiation	GO:0000904	195	0.015
organelle localization	GO:0051640	49	0.015
gtp catabolic process	GO:0006184	2	0.015
positive regulation of catabolic process	GO:0009896	4	0.015
regulation of cellular amine metabolic process	GO:0033238	0	0.015
nuclear export	GO:0051168	1	0.015
single organism reproductive process	GO:0044702	40	0.015
positive regulation of gene expression	GO:0010628	71	0.015
carboxylic acid metabolic process	GO:0019752	22	0.014	Human
response to virus	GO:0009615	21	0.014
negative regulation of cell death	GO:0060548	60	0.014
cell cycle	GO:0007049	93	0.014
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.014
regulation of peptidase activity	GO:0052547	23	0.014
negative regulation of cellular metabolic process	GO:0031324	77	0.014
tissue regeneration	GO:0042246	74	0.014
phosphate containing compound metabolic process	GO:0006796	108	0.013
ncrna metabolic process	GO:0034660	12	0.013	Human
generation of neurons	GO:0048699	385	0.013
regeneration	GO:0031099	91	0.013
gamete generation	GO:0007276	33	0.013
vasculature development	GO:0001944	278	0.013
cellular component biogenesis	GO:0044085	178	0.013
glial cell differentiation	GO:0010001	42	0.013
organic acid transport	GO:0015849	9	0.012
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	1	0.012
muscle structure development	GO:0061061	196	0.012
mesenchymal cell differentiation	GO:0048762	87	0.012
regulation of gtp catabolic process	GO:0033124	2	0.012
positive regulation of cellular catabolic process	GO:0031331	3	0.012
regulation of nitrogen compound metabolic process	GO:0051171	251	0.012
protein acylation	GO:0043543	3	0.012
organelle organization	GO:0006996	227	0.012
nucleobase containing compound biosynthetic process	GO:0034654	205	0.012
multi organism process	GO:0051704	134	0.011
regulation of cell communication	GO:0010646	232	0.011
positive regulation of multicellular organismal process	GO:0051240	52	0.011	Worm
heart development	GO:0007507	313	0.011
regulation of molecular function	GO:0065009	70	0.011
cell cycle g1 s phase transition	GO:0044843	1	0.011
sensory organ development	GO:0007423	393	0.011
spindle assembly	GO:0051225	2	0.011
positive regulation of rna metabolic process	GO:0051254	59	0.011
regulation of gtpase activity	GO:0043087	2	0.011
specification of symmetry	GO:0009799	204	0.011
regulation of signaling	GO:0023051	235	0.010
negative regulation of defense response	GO:0031348	2	0.010
cell projection organization	GO:0030030	284	0.010
positive regulation of developmental process	GO:0051094	50	0.010	Worm
cell surface receptor signaling pathway	GO:0007166	325	0.010
g1 s transition of mitotic cell cycle	GO:0000082	1	0.010

kars disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.077
nervous system disease	DOID:863	0.029
neuropathy	DOID:870	0.029
charcot marie tooth disease	DOID:10595	0.029
charcot marie tooth disease type 2	DOID:0050539	0.029
neuromuscular disease	DOID:440	0.029
neurodegenerative disease	DOID:1289	0.012
central nervous system disease	DOID:331	0.012

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