Danio rerio

33 known processes

sirt1

sirtuin (silent mating type information regulation 2 homolog) 1

(Aliases: im:7148963)

sirt1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ubiquitin dependent protein catabolic processGO:000651130.340
positive regulation of cellular processGO:00485222010.336
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.265
modification dependent macromolecule catabolic processGO:004363230.250
regulation of transcription dna templatedGO:00063552130.232
regulation of biosynthetic processGO:00098892500.228
modification dependent protein catabolic processGO:001994130.202
protein localization to nucleusGO:003450430.174
proteasomal protein catabolic processGO:001049820.149
positive regulation of cellular catabolic processGO:003133130.147
regulation of cellular macromolecule biosynthetic processGO:20001122220.143
cellular protein catabolic processGO:004425740.143
cellular protein metabolic processGO:00442671290.142
regulation of primary metabolic processGO:00800903110.137
proteolysis involved in cellular protein catabolic processGO:005160330.134
protein polyubiquitinationGO:000020940.127
positive regulation of transportGO:005105020.124
positive regulation of biological processGO:00485182530.123
regulation of cell deathGO:00109411030.121
signal transductionGO:00071654550.117
enzyme linked receptor protein signaling pathwayGO:00071671060.112
heart developmentGO:00075073130.111
positive regulation of i kappab kinase nf kappab signalingGO:004312330.104
cellular biosynthetic processGO:00442492860.103
positive regulation of catabolic processGO:000989640.100
regulation of nitrogen compound metabolic processGO:00511712510.100
deathGO:00162651210.098
apoptotic processGO:00069151160.096
single organism nuclear importGO:190259330.094
regulation of protein catabolic processGO:004217610.093
regulation of macromolecule metabolic processGO:00602553170.088
nucleocytoplasmic transportGO:000691340.088
protein targeting to nucleusGO:004474430.087
regulation of rna biosynthetic processGO:20011412130.086
regulation of metabolic processGO:00192223590.085
regulation of i kappab kinase nf kappab signalingGO:004312240.080
sensory organ developmentGO:00074233930.079
protein import into nucleusGO:000660630.077
cellular nitrogen compound metabolic processGO:00346412900.077
regulation of protein modification by small protein conjugation or removalGO:190332030.074
regulation of macromolecule biosynthetic processGO:00105562250.072
establishment of protein localization to organelleGO:007259440.072
nuclear importGO:005117030.072
single organism organelle organizationGO:19025891990.071
tube morphogenesisGO:00352393490.071
heterocycle metabolic processGO:00464832900.069
protein modification processGO:00362111000.069
regulation of nucleic acid templated transcriptionGO:19035062130.069
cognitionGO:005089010.068
cell surface receptor signaling pathwayGO:00071663250.068
nitrogen compound metabolic processGO:00068073190.067
rna biosynthetic processGO:00327741810.067
specification of symmetryGO:00097992040.067
protein dephosphorylationGO:000647030.066
cellular macromolecule biosynthetic processGO:00346452240.066
regulation of protein localization to nucleusGO:190018020.065
nuclear transportGO:005116940.064
nucleobase containing compound metabolic processGO:00061392740.064
hemopoiesisGO:00300971830.064
protein importGO:001703830.063
macromolecule biosynthetic processGO:00090592270.063
regulation of signalingGO:00230512350.061
immune system developmentGO:00025201910.060
myeloid cell differentiationGO:0030099860.060
regulation of programmed cell deathGO:00430671010.059
organelle organizationGO:00069962270.057
generation of neuronsGO:00486993850.056
cell deathGO:00082191210.055
hematopoietic or lymphoid organ developmentGO:00485341910.055
regulation of apoptotic processGO:0042981980.055
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.055
cellular response to organic substanceGO:00713101050.054
immune system processGO:00023762410.054
digestive tract developmentGO:00485652650.054
positive regulation of metabolic processGO:00098931080.054
regulation of response to stimulusGO:00485832690.054
nucleic acid templated transcriptionGO:00976591810.052
i kappab kinase nf kappab signalingGO:000724940.052
transcription dna templatedGO:00063511810.051
intracellular signal transductionGO:0035556850.051
organic substance biosynthetic processGO:19015762890.050
regulation of multicellular organismal processGO:00512392770.049
negative regulation of cellular processGO:00485232830.049
response to chemicalGO:00422213200.049
neuron differentiationGO:00301823530.049
negative regulation of protein phosphorylationGO:000193340.048
regulation of protein transportGO:005122330.048
regulation of protein targetingGO:190353320.048
aromatic compound biosynthetic processGO:00194382170.048
cellular macromolecule metabolic processGO:00442603910.048
regulation of rna metabolic processGO:00512522240.048
regulation of protein complex assemblyGO:004325430.047
regulation of cellular biosynthetic processGO:00313262450.046
regulation of cellular metabolic processGO:00313233200.046
cellular component assemblyGO:00226071700.046
erythrocyte differentiationGO:0030218540.045
regulation of protein ubiquitinationGO:003139630.045
regulation of synaptic growth at neuromuscular junctionGO:000858210.045
eye developmentGO:00016542770.044
organic cyclic compound biosynthetic processGO:19013622230.044
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.043
erythrocyte developmentGO:0048821240.042
positive regulation of apoptotic signaling pathwayGO:200123510.042
proteolysisGO:0006508380.041
regulation of signal transductionGO:00099662250.041
cellular nitrogen compound biosynthetic processGO:00442712180.041
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.041
synaptic growth at neuromuscular junctionGO:005112420.041
rna metabolic processGO:00160702190.040
cellular component morphogenesisGO:00329893360.040
meiosis iGO:000712710.040
response to organic substanceGO:00100331530.040
organic cyclic compound metabolic processGO:19013603010.040
regulation of nucleobase containing compound metabolic processGO:00192192500.040
protein metabolic processGO:00195381830.039
adult behaviorGO:003053420.039
g1 s transition of mitotic cell cycleGO:000008210.039
regulation of reproductive processGO:200024140.038
biosynthetic processGO:00090582940.038
agingGO:000756820.038
macromolecule modificationGO:00434121110.038
negative regulation of kinase activityGO:003367340.037
regulation of proteolysisGO:0030162240.037
single organism localizationGO:19025782250.036
programmed cell deathGO:00125011190.036
cellular component movementGO:00069283350.036
heterocycle biosynthetic processGO:00181302150.036
regulation of protein import into nucleusGO:004230620.036
apoptotic process involved in developmentGO:190274220.035
positive regulation of cellular component biogenesisGO:004408930.035
regulation of gene expressionGO:00104682650.035
centrosome organizationGO:005129710.034
positive regulation of protein complex assemblyGO:003133420.034
regulation of synapse assemblyGO:005196330.034
cell agingGO:000756920.033
mesenchyme developmentGO:00604851270.033
developmental programmed cell deathGO:001062340.032
amine metabolic processGO:000930820.032
negative regulation of programmed cell deathGO:0043069580.031
internal protein amino acid acetylationGO:000647520.031
regulation of circadian rhythmGO:004275240.031
protein acetylationGO:000647320.030
cell cycle g1 s phase transitionGO:004484310.030
regulation of bindingGO:005109830.030
catecholamine metabolic processGO:000658420.030
negative regulation of biological processGO:00485193040.030
regulation of establishment of protein localizationGO:007020140.030
multicellular organism growthGO:003526440.030
regulation of jak stat cascadeGO:004642530.030
determination of bilateral symmetryGO:00098552040.030
centrosome cycleGO:000709810.030
chemosensory behaviorGO:000763510.029
cellular component disassemblyGO:002241110.029
digestive system developmentGO:00551232890.029
embryonic organ developmentGO:00485683810.029
myeloid cell developmentGO:0061515320.029
neuron remodelingGO:001632210.029
growthGO:00400071740.029
regulation of cell communicationGO:00106462320.029
peptidyl serine phosphorylationGO:001810510.028
determination of intestine left right asymmetryGO:007190820.028
regulation of intracellular signal transductionGO:1902531570.028
regulation of cellular protein catabolic processGO:190336210.028
positive regulation of macromolecule metabolic processGO:0010604930.028
morphogenesis of an epitheliumGO:00020093330.028
cell projection organizationGO:00300302840.028
single organism metabolic processGO:00447102170.028
regulation of nucleocytoplasmic transportGO:004682220.028
cellular response to endogenous stimulusGO:0071495680.027
urogenital system developmentGO:0001655970.027
cellular aromatic compound metabolic processGO:00067252950.027
negative regulation of protein transportGO:005122430.027
negative regulation of cell deathGO:0060548600.027
positive regulation of cytokine productionGO:000181920.027
negative regulation of tor signalingGO:003200720.027
response to oxygen containing compoundGO:1901700550.027
nucleic acid metabolic processGO:00903042440.027
cellular response to external stimulusGO:007149620.026
protein modification by small protein conjugation or removalGO:0070647140.026
regulation of cytoplasmic transportGO:190364940.026
mitochondrion organizationGO:000700540.026
meiotic nuclear divisionGO:000712640.026
negative regulation of apoptotic processGO:0043066550.026
establishment of localization in cellGO:0051649770.026
cellular response to hormone stimulusGO:0032870390.025
positive regulation of nucleoside metabolic processGO:004597910.025
regulation of cell shapeGO:000836010.025
erythrocyte homeostasisGO:0034101550.025
positive regulation of cell deathGO:0010942290.025
peptidyl serine modificationGO:001820920.024
larval developmentGO:000216420.024
chromosome organization involved in meiosisGO:007019210.024
determination of left right symmetryGO:00073681790.024
positive regulation of cellular metabolic processGO:0031325940.024
neuron developmentGO:00486662620.024
locomotor rhythmGO:004547530.024
cellular response to stressGO:0033554620.024
heart morphogenesisGO:00030071560.024
response to corticosteroidGO:003196010.024
negative regulation of nucleic acid templated transcriptionGO:1903507450.024
cellular protein modification processGO:00064641000.024
blood vessel developmentGO:00015682460.024
g2 dna damage checkpointGO:003157230.023
regulation of synapse organizationGO:005080730.023
protein k48 linked ubiquitinationGO:007093610.023
phosphate containing compound metabolic processGO:00067961080.023
cellular localizationGO:0051641970.023
central nervous system developmentGO:00074173870.023
protein acylationGO:004354330.023
single organism transportGO:00447652060.023
autophagyGO:000691440.023
regulation of reactive oxygen species metabolic processGO:200037720.023
response to uvGO:000941130.022
regulation of cell activationGO:005086510.022
protein localizationGO:0008104400.022
extrinsic apoptotic signaling pathwayGO:009719130.022
cellular response to chemical stimulusGO:00708871570.022
camera type eye developmentGO:00430102220.022
organelle assemblyGO:00709251100.022
skeletal muscle organ developmentGO:0060538780.022
negative regulation of protein localization to nucleusGO:190018120.022
positive regulation of chromatin modificationGO:190331010.021
positive regulation of nitrogen compound metabolic processGO:0051173690.021
positive regulation of canonical wnt signaling pathwayGO:009026340.021
protein secretionGO:000930610.021
muscle organ developmentGO:00075171010.021
meiotic cell cycle processGO:190304630.021
head developmentGO:00603223030.021
negative regulation of protein kinase activityGO:000646940.021
cell proliferationGO:0008283800.020
regulation of cellular amino acid metabolic processGO:000652100.020
multi organism processGO:00517041340.020
taxisGO:00423301090.020
cell projection morphogenesisGO:00488582440.020
mitotic cell cycle embryonicGO:004544820.020
myeloid cell homeostasisGO:0002262560.020
retina development in camera type eyeGO:00600411460.020
negative regulation of intracellular protein transportGO:009031730.020
negative regulation of nucleocytoplasmic transportGO:004682320.020
negative regulation of nitrogen compound metabolic processGO:0051172590.019
response to hormoneGO:0009725480.019
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:004278710.019
negative regulation of biosynthetic processGO:0009890550.019
cilium organizationGO:0044782710.019
peptidyl lysine acetylationGO:001839420.019
response to stressGO:00069502630.019
negative regulation of cellular metabolic processGO:0031324770.019
system processGO:00030081850.019
lateral inhibitionGO:004633110.019
regulation of nucleotide catabolic processGO:003081120.018
erk1 and erk2 cascadeGO:007037140.018
post embryonic organ developmentGO:004856940.018
developmental growthGO:00485891660.018
maintenance of locationGO:005123540.018
phosphorus metabolic processGO:00067931090.018
negative regulation of metabolic processGO:0009892860.018
microtubule organizing center organizationGO:003102310.018
protein modification by small protein conjugationGO:0032446130.018
response to ketoneGO:190165410.018
regulation of cytokine productionGO:000181730.018
cellular component biogenesisGO:00440851780.018
positive regulation of cell communicationGO:0010647560.018
response to endogenous stimulusGO:0009719830.018
brain developmentGO:00074202930.018
cellular respirationGO:004533330.018
negative regulation of macromolecule metabolic processGO:0010605760.017
kidney developmentGO:0001822920.017
embryonic limb morphogenesisGO:003032620.017
cell morphogenesisGO:00009022890.017
positive regulation of cell cycleGO:004578730.017
phagocytosisGO:000690930.017
positive regulation of secretionGO:005104710.017
histone modificationGO:0016570200.017
cell migrationGO:00164772370.017
stem cell proliferationGO:007208940.016
positive regulation of immune effector processGO:000269930.016
centrosome duplicationGO:005129810.016
mitotic dna damage checkpointGO:004477340.016
homeostasis of number of cellsGO:0048872620.016
mitotic cell cycleGO:0000278640.016
cilium assemblyGO:0042384580.016
homeostatic processGO:00425921420.016
response to hydrogen peroxideGO:004254230.016
cellular amine metabolic processGO:004410620.016
cellular response to nutrient levelsGO:003166920.016
regulation of phosphorus metabolic processGO:0051174430.016
renal system developmentGO:0072001940.016
negative regulation of response to cytokine stimulusGO:006076120.016
mitotic dna integrity checkpointGO:004477440.016
covalent chromatin modificationGO:0016569200.016
epithelial cell differentiationGO:00308551160.016
regulation of multicellular organism growthGO:004001440.016
internal peptidyl lysine acetylationGO:001839320.016
regulation of multicellular organismal developmentGO:20000262230.016
positive regulation of signalingGO:0023056560.016
regulation of filopodium assemblyGO:005148920.016
response to external stimulusGO:00096052640.016
regulation of phosphate metabolic processGO:0019220430.015
peptide transportGO:001583310.015
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.015
positive regulation of cytoskeleton organizationGO:005149530.015
leukocyte differentiationGO:0002521250.015
wnt signaling pathwayGO:0016055800.015
positive regulation of map kinase activityGO:004340630.015
positive regulation of dna metabolic processGO:005105410.015
gene expressionGO:00104672520.015
sensory organ morphogenesisGO:00905962000.015
regulation of nucleoside metabolic processGO:000911820.015
determination of heart left right asymmetryGO:00613711170.015
regulation of intracellular protein transportGO:003315730.015
pancreas developmentGO:0031016840.015
positive regulation of purine nucleotide catabolic processGO:003312310.015
sequestering of calcium ionGO:005120830.015
positive regulation of cellular amino acid metabolic processGO:004576400.014
regulation of purine nucleotide catabolic processGO:003312120.014
chromosome organizationGO:0051276310.014
transportGO:00068102200.014
oxoacid metabolic processGO:0043436310.014
negative regulation of intracellular signal transductionGO:1902532220.014
regulation of cell projection assemblyGO:006049140.014
positive regulation of nucleotide catabolic processGO:003081310.014
single organism cellular localizationGO:1902580460.014
peptidyl threonine phosphorylationGO:001810710.014
myeloid leukocyte differentiationGO:0002573150.014
cellular response to extracellular stimulusGO:003166820.014
negative regulation of intracellular transportGO:003238730.014
nucleobase containing compound biosynthetic processGO:00346542050.014
endocrine processGO:005088620.014
negative regulation of protein serine threonine kinase activityGO:007190120.014
response to drugGO:004249330.014
small molecule metabolic processGO:0044281770.014
sleepGO:003043110.014
odontogenesis of dentin containing toothGO:004247510.014
negative regulation of cell communicationGO:0010648960.014
cellular response to biotic stimulusGO:007121630.014
gastrulationGO:00073692080.014
positive regulation of programmed cell deathGO:0043068290.014
production of molecular mediator of immune responseGO:000244020.014
regulation of response to cytokine stimulusGO:006075930.014
positive regulation of response to stimulusGO:0048584800.013
cell projection assemblyGO:0030031640.013
sequestering of metal ionGO:005123830.013
glial cell proliferationGO:001400940.013
cellular ketone metabolic processGO:0042180110.013
cellular response to starvationGO:000926710.013
cytoskeleton organizationGO:0007010960.013
ras protein signal transductionGO:000726570.013
double strand break repairGO:000630230.013
chordate embryonic developmentGO:00430092710.013
regulation of carbohydrate metabolic processGO:000610940.013
negative regulation of cytokine productionGO:000181810.013
cell motilityGO:00488702440.013
digestive tract morphogenesisGO:00485462310.013
regulation of molecular functionGO:0065009700.013
response to glucocorticoidGO:005138410.013
positive regulation of cytosolic calcium ion concentrationGO:000720440.013
positive regulation of erk1 and erk2 cascadeGO:007037420.013
muscle tissue developmentGO:00605371100.013
stem cell differentiationGO:00488631170.013
mesenchymal cell developmentGO:0014031780.013
organonitrogen compound metabolic processGO:1901564740.012
fertilizationGO:000956630.012
negative regulation of cellular biosynthetic processGO:0031327550.012
negative regulation of transcription dna templatedGO:0045892450.012
regulation of cellular protein metabolic processGO:0032268520.012
female sex differentiationGO:004666040.012
tissue remodelingGO:004877140.012
protein complex disassemblyGO:004324110.012
cellular modified amino acid metabolic processGO:000657530.012
dicarboxylic acid transportGO:000683510.012
regulation of cellular ketone metabolic processGO:001056570.012
striated muscle tissue developmentGO:00147061100.012
regulation of protein metabolic processGO:0051246560.012
regulation of microtubule cytoskeleton organizationGO:007050730.012
regulation of neurogenesisGO:0050767870.012
mesenchymal cell differentiationGO:0048762870.012
positive regulation of cellular amine metabolic processGO:003324000.012
cellular amino acid metabolic processGO:000652070.012
positive regulation of epithelial cell proliferationGO:005067910.012
cellular response to lipopolysaccharideGO:007122230.012
negative regulation of signal transductionGO:0009968940.012
protein catabolic processGO:003016370.012
cellular response to radiationGO:007147840.012
embryonic organ morphogenesisGO:00485622740.012
b cell activationGO:004211320.012
negative regulation of gliogenesisGO:001401410.012
neuron projection developmentGO:00311751800.012
regulation of erk1 and erk2 cascadeGO:007037240.012
regulation of protein bindingGO:004339330.012
regulation of organelle assemblyGO:190211540.012
cellular response to molecule of bacterial originGO:007121930.011
response to hexoseGO:000974630.011
positive regulation of cellular biosynthetic processGO:0031328680.011
synaptic target recognitionGO:000803910.011
blood vessel morphogenesisGO:00485142160.011
nuclear exportGO:005116810.011
development of primary female sexual characteristicsGO:004654540.011
phosphorylationGO:0016310690.011
anterior posterior pattern specificationGO:00099521520.011
regulation of cellular component organizationGO:0051128860.011
muscle structure developmentGO:00610611960.011
regulation of blood coagulationGO:003019310.011
membrane invaginationGO:001032410.011
response to vitaminGO:003327330.011
female gonad developmentGO:000858540.011
negative regulation of rna metabolic processGO:0051253480.011
mitochondrial transportGO:000683920.011
organic substance transportGO:0071702580.011
catechol containing compound metabolic processGO:000971220.011
negative regulation of secretionGO:005104820.011
cell fate specificationGO:0001708680.011
regulation of calcium ion transportGO:005192420.011
cellular carbohydrate metabolic processGO:004426240.011
response to alkaloidGO:004327920.011
macroautophagyGO:001623610.011
response to amino acidGO:004320020.011
negative regulation of response to stimulusGO:00485851040.011
positive regulation of chromosome organizationGO:200125210.011
negative regulation of macromolecule biosynthetic processGO:0010558480.011
cilium morphogenesisGO:0060271850.011
negative regulation of sequestering of calcium ionGO:005128340.011
positive regulation of transcription dna templatedGO:0045893570.011
regulation of biological qualityGO:00650082630.010
regulation of organ growthGO:004662030.010
neural crest cell differentiationGO:0014033720.010
negative regulation of secretion by cellGO:190353120.010
meiotic chromosome segregationGO:004513230.010
cellular response to light stimulusGO:007148240.010
epiboly involved in gastrulation with mouth forming secondGO:0055113350.010
positive regulation of cell divisionGO:005178120.010
startle responseGO:000196440.010
regulation of peptidyl tyrosine phosphorylationGO:005073010.010
vasculature developmentGO:00019442780.010
response to monosaccharideGO:003428430.010
positive regulation of macromolecule biosynthetic processGO:0010557590.010
lipid storageGO:001991510.010
cell part morphogenesisGO:00329902460.010
protein polymerizationGO:005125840.010
cell fate commitmentGO:0045165990.010
positive regulation of protein metabolic processGO:0051247230.010

sirt1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.028
cancerDOID:16200.028
organ system cancerDOID:005068600.024
disease of anatomical entityDOID:700.017
musculoskeletal system diseaseDOID:1700.017
muscular diseaseDOID:008000000.010