Danio rerio

41 known processes

ppm1k

protein phosphatase 1K (PP2C domain containing)

(Aliases: zgc:113207,im:6912645)

ppm1k biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.120
positive regulation of transportGO:005105020.113
nuclear transportGO:005116940.096
amine metabolic processGO:000930820.092
establishment of protein localization to organelleGO:007259440.085
cellular component morphogenesisGO:00329893360.083
cellular macromolecule metabolic processGO:00442603910.082
regulation of protein transportGO:005122330.081
nitrogen compound metabolic processGO:00068073190.079
agingGO:000756820.077
regulation of biological qualityGO:00650082630.076
cellular nitrogen compound metabolic processGO:00346412900.075
generation of neuronsGO:00486993850.075
organic cyclic compound metabolic processGO:19013603010.073
single organism nuclear importGO:190259330.071
protein import into nucleusGO:000660630.071
nucleocytoplasmic transportGO:000691340.071
nucleobase containing compound metabolic processGO:00061392740.070
regulation of nitrogen compound metabolic processGO:00511712510.070
single organism metabolic processGO:00447102170.069
autophagyGO:000691440.068
aromatic compound biosynthetic processGO:00194382170.067
response to chemicalGO:00422213200.067
stem cell proliferationGO:007208940.067
regulation of primary metabolic processGO:00800903110.067
cellular macromolecule biosynthetic processGO:00346452240.067
regulation of multicellular organismal processGO:00512392770.066
protein localization to nucleusGO:003450430.066
maintenance of locationGO:005123540.065
cell morphogenesisGO:00009022890.065
nuclear importGO:005117030.065
biosynthetic processGO:00090582940.063
negative regulation of cellular processGO:00485232830.062
protein importGO:001703830.061
regulation of metabolic processGO:00192223590.060
regulation of intracellular protein transportGO:003315730.060
regulation of cellular metabolic processGO:00313233200.059
multicellular organism growthGO:003526440.059
positive regulation of cellular catabolic processGO:003133130.059
regulation of nucleobase containing compound metabolic processGO:00192192500.058
sensory organ developmentGO:00074233930.058
chordate embryonic developmentGO:00430092710.058
single organism transportGO:00447652060.057
guanosine containing compound catabolic processGO:190106920.055
cellular amine metabolic processGO:004410620.055
negative regulation of biological processGO:00485193040.055
protein targeting to nucleusGO:004474430.054
cellular biosynthetic processGO:00442492860.053
neuron developmentGO:00486662620.052
heterocycle metabolic processGO:00464832900.052
regulation of protein targetingGO:190353320.052
organic substance biosynthetic processGO:19015762890.052
positive regulation of catabolic processGO:000989640.051
regulation of establishment of protein localizationGO:007020140.051
central nervous system developmentGO:00074173870.051
system processGO:00030081850.051
cell projection organizationGO:00300302840.050
cellular aromatic compound metabolic processGO:00067252950.050
signal transductionGO:00071654550.049
neuron differentiationGO:00301823530.049
regulation of cellular amine metabolic processGO:003323800.049
regulation of autophagyGO:001050630.048
gtp catabolic processGO:000618420.048
positive regulation of cellular component biogenesisGO:004408930.048
nucleic acid templated transcriptionGO:00976591810.046
negative regulation of protein phosphorylationGO:000193340.046
guanosine containing compound metabolic processGO:190106840.045
gtp metabolic processGO:004603940.045
regulation of multicellular organism growthGO:004001440.045
regulation of cell communicationGO:00106462320.044
cellular nitrogen compound biosynthetic processGO:00442712180.044
organic cyclic compound biosynthetic processGO:19013622230.043
morphogenesis of an epitheliumGO:00020093330.043
transportGO:00068102200.043
organonitrogen compound metabolic processGO:1901564740.043
regulation of inflammatory responseGO:005072720.042
response to drugGO:004249330.042
cell projection morphogenesisGO:00488582440.041
small molecule metabolic processGO:0044281770.041
heart developmentGO:00075073130.040
phosphate containing compound metabolic processGO:00067961080.040
regulation of protein catabolic processGO:004217610.040
organelle organizationGO:00069962270.040
transcription dna templatedGO:00063511810.039
regulation of response to stimulusGO:00485832690.039
lipid storageGO:001991510.039
regulation of protein import into nucleusGO:004230620.039
regulation of nucleic acid templated transcriptionGO:19035062130.039
cellular ketone metabolic processGO:0042180110.039
positive regulation of biological processGO:00485182530.039
gene expressionGO:00104672520.039
embryonic organ morphogenesisGO:00485622740.039
regulation of transcription dna templatedGO:00063552130.038
macromolecule biosynthetic processGO:00090592270.038
somatic muscle developmentGO:000752540.038
cell morphogenesis involved in differentiationGO:00009041950.038
regulation of protein localization to nucleusGO:190018020.038
cellular component movementGO:00069283350.037
heterocycle biosynthetic processGO:00181302150.037
rna metabolic processGO:00160702190.037
regulation of cellular amino acid metabolic processGO:000652100.037
regulation of developmental processGO:00507932470.037
regulation of gene expressionGO:00104682650.037
cellular response to nutrient levelsGO:003166920.037
regulation of cytokine productionGO:000181730.036
locomotionGO:00400113130.036
nucleobase containing compound biosynthetic processGO:00346542050.036
embryonic organ developmentGO:00485683810.036
phosphorus metabolic processGO:00067931090.036
positive regulation of purine nucleotide catabolic processGO:003312310.036
homeostatic processGO:00425921420.036
regulation of macromolecule metabolic processGO:00602553170.036
head developmentGO:00603223030.036
regulation of cell deathGO:00109411030.035
macroautophagyGO:001623610.035
negative regulation of cellular catabolic processGO:003133030.035
regulation of synaptic plasticityGO:004816710.034
digestive system developmentGO:00551232890.034
modification dependent protein catabolic processGO:001994130.034
regulation of cell shapeGO:000836010.034
regulation of nucleoside metabolic processGO:000911820.034
protein metabolic processGO:00195381830.034
cellular response to chemical stimulusGO:00708871570.033
regulation of purine nucleotide catabolic processGO:003312120.033
tube morphogenesisGO:00352393490.033
negative regulation of catabolic processGO:000989530.033
cell motilityGO:00488702440.033
regulation of organelle assemblyGO:190211540.033
regulation of programmed cell deathGO:00430671010.033
eye developmentGO:00016542770.033
ubiquitin dependent protein catabolic processGO:000651130.032
negative regulation of kinase activityGO:003367340.032
oxoacid metabolic processGO:0043436310.032
regulation of apoptotic processGO:0042981980.032
positive regulation of secretionGO:005104710.032
positive regulation of secretion by cellGO:190353210.032
compound eye developmentGO:004874920.031
response to stressGO:00069502630.031
peptidyl serine modificationGO:001820920.031
cellular component biogenesisGO:00440851780.031
proteolysis involved in cellular protein catabolic processGO:005160330.031
immune system processGO:00023762410.031
response to organic substanceGO:00100331530.031
ribonucleoside monophosphate catabolic processGO:000915840.031
regulation of bindingGO:005109830.031
cell part morphogenesisGO:00329902460.031
peptidyl serine phosphorylationGO:001810510.031
cognitionGO:005089010.031
protein acetylationGO:000647320.031
regulation of nucleotide catabolic processGO:003081120.031
regulation of signalingGO:00230512350.030
establishment of localizationGO:00512342440.030
single organism localizationGO:19025782250.030
regulation of nucleocytoplasmic transportGO:004682220.030
cellular response to starvationGO:000926710.030
protein secretionGO:000930610.030
cellular protein catabolic processGO:004425740.029
rna biosynthetic processGO:00327741810.029
modification dependent macromolecule catabolic processGO:004363230.029
protein modification processGO:00362111000.029
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.029
localization of cellGO:00516742440.029
cellular response to external stimulusGO:007149620.029
regulation of cellular ketone metabolic processGO:001056570.029
organic acid metabolic processGO:0006082310.029
regulation of macromolecule biosynthetic processGO:00105562250.029
apoptotic processGO:00069151160.029
heart contractionGO:0060047710.028
programmed cell deathGO:00125011190.028
carboxylic acid metabolic processGO:0019752220.028
vasculature developmentGO:00019442780.028
regulation of i kappab kinase nf kappab signalingGO:004312240.028
cell morphogenesis involved in neuron differentiationGO:00486671630.028
positive regulation of stress activated mapk cascadeGO:003287430.028
regulation of cytoplasmic transportGO:190364940.028
cellular amino acid metabolic processGO:000652070.028
purine ribonucleoside monophosphate catabolic processGO:000916940.028
cellular protein modification processGO:00064641000.027
cell surface receptor signaling pathwayGO:00071663250.027
regulation of gtp catabolic processGO:003312420.027
digestive tract morphogenesisGO:00485462310.027
embryo development ending in birth or egg hatchingGO:00097922710.027
muscle cell differentiationGO:00426921390.027
negative regulation of protein kinase activityGO:000646940.027
brain developmentGO:00074202930.027
cellular component assemblyGO:00226071700.027
positive regulation of gtp catabolic processGO:003312610.027
regulation of signal transductionGO:00099662250.026
positive regulation of cellular processGO:00485222010.026
positive regulation of cytokine productionGO:000181920.026
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.026
cellular protein metabolic processGO:00442671290.026
intracellular signal transductionGO:0035556850.026
positive regulation of map kinase activityGO:004340630.025
regulation of protein ubiquitinationGO:003139630.025
regulation of response to extracellular stimulusGO:003210410.025
stem cell divisionGO:001714510.025
camera type eye developmentGO:00430102220.025
regulation of rna biosynthetic processGO:20011412130.025
regulation of cellular biosynthetic processGO:00313262450.025
regulation of biosynthetic processGO:00098892500.025
single organism cellular localizationGO:1902580460.025
macromolecule modificationGO:00434121110.025
skeletal system developmentGO:00015011810.025
sensory organ morphogenesisGO:00905962000.025
neuroblast proliferationGO:000740520.024
positive regulation of cellular amine metabolic processGO:003324000.024
meiotic nuclear divisionGO:000712640.024
positive regulation of gtpase activityGO:004354710.024
atp catabolic processGO:000620040.024
regulation of cellular macromolecule biosynthetic processGO:20001122220.024
action potentialGO:0001508190.024
internal protein amino acid acetylationGO:000647520.024
nucleic acid metabolic processGO:00903042440.024
axonogenesisGO:00074091520.024
response to alkaloidGO:004327920.024
nucleoside monophosphate catabolic processGO:000912540.024
regulation of multicellular organismal developmentGO:20000262230.024
response to topologically incorrect proteinGO:003596620.023
microtubule organizing center organizationGO:003102310.023
proteasomal protein catabolic processGO:001049820.023
positive regulation of cellular amino acid metabolic processGO:004576400.023
purine nucleoside monophosphate catabolic processGO:000912840.023
positive regulation of nitrogen compound metabolic processGO:0051173690.023
positive regulation of cellular metabolic processGO:0031325940.023
mononuclear cell proliferationGO:003294310.023
cell migrationGO:00164772370.023
regulation of gtpase activityGO:004308720.023
blood vessel developmentGO:00015682460.023
cytokinesisGO:000091030.023
heart processGO:0003015710.022
startle responseGO:000196440.022
gastrulationGO:00073692080.022
neurological system processGO:0050877620.022
regulation of circadian rhythmGO:004275240.022
growthGO:00400071740.021
negative regulation of protein transportGO:005122430.021
regulation of rna metabolic processGO:00512522240.021
cellular response to extracellular stimulusGO:003166820.021
leukocyte proliferationGO:007066110.021
single organism organelle organizationGO:19025891990.021
regulation of cell activationGO:005086510.021
peptide transportGO:001583310.021
positive regulation of nucleotide catabolic processGO:003081310.021
response to abiotic stimulusGO:00096281220.021
determination of bilateral symmetryGO:00098552040.021
positive regulation of nucleoside metabolic processGO:004597910.020
transcription from rna polymerase ii promoterGO:0006366800.020
cell projection assemblyGO:0030031640.020
centrosome organizationGO:005129710.020
cellular localizationGO:0051641970.020
protein acylationGO:004354330.020
phagocytosisGO:000690930.020
adult behaviorGO:003053420.020
positive regulation of cell communicationGO:0010647560.020
cellular component disassemblyGO:002241110.019
positive regulation of cell activationGO:005086710.019
regulation of protein modification by small protein conjugation or removalGO:190332030.019
endosomal transportGO:001619720.019
response to nutrientGO:000758430.019
i kappab kinase nf kappab signalingGO:000724940.019
hemopoiesisGO:00300971830.019
digestive tract developmentGO:00485652650.019
regulation of molecular functionGO:0065009700.019
regulation of cell developmentGO:00602841000.019
regulation of cellular protein catabolic processGO:190336210.019
neuron projection morphogenesisGO:00488121610.019
specification of symmetryGO:00097992040.019
regulation of circadian sleep wake cycleGO:004274910.018
negative regulation of apoptotic processGO:0043066550.018
establishment of localization in cellGO:0051649770.018
regulation of catalytic activityGO:0050790550.018
positive regulation of response to stimulusGO:0048584800.018
regulation of metal ion transportGO:001095940.018
sensory perception of painGO:001923310.018
hormone transportGO:000991420.018
regulation of localizationGO:00328791040.018
purine nucleotide metabolic processGO:0006163270.018
response to bacteriumGO:0009617580.018
synaptic growth at neuromuscular junctionGO:005112420.018
macromolecule localizationGO:0033036540.018
regulation of reproductive processGO:200024140.018
muscle structure developmentGO:00610611960.018
lymphocyte proliferationGO:004665110.018
positive regulation of neuron deathGO:190121610.018
regulation of cellular component organizationGO:0051128860.017
determination of heart left right asymmetryGO:00613711170.017
positive regulation of cell cycleGO:004578730.017
cell deathGO:00082191210.017
protein dephosphorylationGO:000647030.017
ion transportGO:00068111140.017
immune system developmentGO:00025201910.017
membrane fusionGO:006102520.017
regulation of cell projection assemblyGO:006049140.017
extrinsic apoptotic signaling pathwayGO:009719130.017
blood circulationGO:0008015870.017
neuron projection developmentGO:00311751800.017
phosphorylationGO:0016310690.017
epithelial tube morphogenesisGO:00605621480.017
organophosphate metabolic processGO:0019637370.017
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.017
regulation of synaptic growth at neuromuscular junctionGO:000858210.017
rna localizationGO:000640340.017
regulation of reactive oxygen species metabolic processGO:200037720.017
inner ear developmentGO:00488391260.017
negative regulation of response to stimulusGO:00485851040.017
organic substance transportGO:0071702580.017
secondary metabolic processGO:001974830.017
positive regulation of signalingGO:0023056560.017
circadian sleep wake cycle sleepGO:005080210.017
activation of mapk activityGO:000018730.017
cellular response to organic substanceGO:00713101050.017
response to uvGO:000941130.016
neuronal action potentialGO:0019228180.016
pigmentationGO:0043473850.016
negative regulation of cytoplasmic transportGO:190365020.016
positive regulation of immune effector processGO:000269930.016
carbohydrate homeostasisGO:003350010.016
mitochondrion organizationGO:000700540.016
stem cell maintenanceGO:001982740.016
golgi vesicle transportGO:004819330.016
single organism membrane fusionGO:004480120.016
positive regulation of cell adhesionGO:004578510.016
cellular response to molecule of bacterial originGO:007121930.016
cellular carbohydrate metabolic processGO:004426240.016
hematopoietic or lymphoid organ developmentGO:00485341910.016
liver developmentGO:0001889960.016
protein polymerizationGO:005125840.016
regulation of synapse organizationGO:005080730.016
cellular response to stressGO:0033554620.016
ear developmentGO:00435831270.016
fat soluble vitamin metabolic processGO:000677540.016
developmental growthGO:00485891660.016
photoreceptor cell differentiationGO:0046530550.015
regulation of peptidyl tyrosine phosphorylationGO:005073010.015
macromolecular complex subunit organizationGO:0043933740.015
regulation of response to nutrient levelsGO:003210710.015
positive regulation of jnk cascadeGO:004633030.015
regulation of transcription from rna polymerase ii promoterGO:00063571140.015
peptidyl lysine acetylationGO:001839420.015
female sex differentiationGO:004666040.015
positive regulation of macromolecule metabolic processGO:0010604930.015
regulation of ras gtpase activityGO:003231820.015
regulation of circadian sleep wake cycle sleepGO:004518710.015
response to ketoneGO:190165410.015
response to external stimulusGO:00096052640.015
inositol lipid mediated signalingGO:004801720.015
positive regulation of cytosolic calcium ion concentrationGO:000720440.015
positive regulation of gene expressionGO:0010628710.015
cilium morphogenesisGO:0060271850.015
glucose homeostasisGO:004259310.015
regulation of membrane potentialGO:0042391230.015
transmission of nerve impulseGO:0019226190.015
cellular response to biotic stimulusGO:007121630.015
response to endogenous stimulusGO:0009719830.015
response to carbohydrateGO:000974330.015
positive regulation of cytoskeleton organizationGO:005149530.015
negative regulation of metabolic processGO:0009892860.015
internal peptidyl lysine acetylationGO:001839320.015
single organism biosynthetic processGO:0044711710.015
cellular response to radiationGO:007147840.015
retina development in camera type eyeGO:00600411460.014
tissue remodelingGO:004877140.014
embryonic skeletal system developmentGO:0048706970.014
negative regulation of mapk cascadeGO:004340940.014
positive regulation of metabolic processGO:00098931080.014
regulation of anatomical structure morphogenesisGO:00226031300.014
deathGO:00162651210.014
sequestering of metal ionGO:005123830.014
positive regulation of nucleobase containing compound metabolic processGO:0045935690.014
regulation of calcium ion transportGO:005192420.014
reactive oxygen species biosynthetic processGO:190340910.014
negative regulation of autophagyGO:001050710.014
lipid homeostasisGO:005508830.014
membrane invaginationGO:001032410.014
negative regulation of intracellular transportGO:003238730.014
organelle fusionGO:004828430.014
energy reserve metabolic processGO:000611220.014
regulation of protein metabolic processGO:0051246560.014
response to organic cyclic compoundGO:0014070510.014
regulation of cell substrate adhesionGO:001081010.014
nucleobase containing small molecule metabolic processGO:0055086320.014
multicellular organismal signalingGO:0035637220.014
regulation of protein complex assemblyGO:004325430.014
response to hydrogen peroxideGO:004254230.014
small gtpase mediated signal transductionGO:000726480.014
response to monosaccharideGO:003428430.014
hormone secretionGO:004687920.014
negative regulation of secretionGO:005104820.014
protein localization to plasma membraneGO:007265910.014
negative regulation of macromolecule metabolic processGO:0010605760.013
negative regulation of nucleocytoplasmic transportGO:004682320.013
positive regulation of nucleic acid templated transcriptionGO:1903508570.013
regulation of hormone secretionGO:004688320.013
regulation of cell projection organizationGO:0031344440.013
regulation of extrinsic apoptotic signaling pathwayGO:200123630.013
female gonad developmentGO:000858540.013
mitotic cell cycleGO:0000278640.013
regulation of response to stressGO:0080134360.013
regulation of transporter activityGO:003240920.013
positive regulation of protein complex assemblyGO:003133420.013
centrosome cycleGO:000709810.013
cell agingGO:000756920.013
g1 s transition of mitotic cell cycleGO:000008210.013
nuclear exportGO:005116810.013
cell substrate adhesionGO:003158940.013
regulation of microtubule cytoskeleton organizationGO:007050730.013
regulation of muscle contractionGO:000693730.013
hepaticobiliary system developmentGO:0061008980.013
protein complex localizationGO:003150310.013
negative regulation of signalingGO:0023057960.013
determination of left right symmetryGO:00073681790.013
protein phosphorylationGO:0006468470.013
production of molecular mediator of immune responseGO:000244020.013
response to radiationGO:0009314510.013
regulation of tube sizeGO:003515020.013
cellular response to lipopolysaccharideGO:007122230.013
phagocytosis engulfmentGO:000691110.013
angiogenesisGO:00015251580.013
carbohydrate derivative metabolic processGO:1901135610.013
negative regulation of defense responseGO:003134820.013
response to woundingGO:00096111160.013
regulation of cell differentiationGO:00455951420.013
cellular response to endogenous stimulusGO:0071495680.013
regulation of neurogenesisGO:0050767870.013
positive regulation of signal transductionGO:0009967560.013
photoreceptor cell developmentGO:0042461400.013
negative regulation of signal transductionGO:0009968940.013
renal system developmentGO:0072001940.013
germ line stem cell maintenanceGO:003071820.013
axon developmentGO:00615641660.013
erk1 and erk2 cascadeGO:007037140.013
regulation of production of molecular mediator of immune responseGO:000270010.012
cellular component assembly involved in morphogenesisGO:00109271070.012
regulation of dendrite developmentGO:005077330.012
regulation of jun kinase activityGO:004350630.012
negative regulation of intracellular protein transportGO:009031730.012
cell proliferationGO:0008283800.012
negative regulation of translationGO:001714810.012
positive regulation of i kappab kinase nf kappab signalingGO:004312330.012
response to biotic stimulusGO:0009607970.012
development of primary female sexual characteristicsGO:004654540.012
ras protein signal transductionGO:000726570.012
heart morphogenesisGO:00030071560.012
chemical homeostasisGO:0048878490.012
regulation of stem cell proliferationGO:007209120.012
regulation of nervous system developmentGO:0051960900.012
cytoskeleton organizationGO:0007010960.012
negative regulation of gene expressionGO:0010629650.012
response to unfolded proteinGO:000698620.012
circadian sleep wake cycle processGO:002241020.012
negative regulation of cellular metabolic processGO:0031324770.012
embryonic cranial skeleton morphogenesisGO:0048701900.012
regulation of wound healingGO:006104120.012
eye morphogenesisGO:00485921440.012
nitric oxide metabolic processGO:004620920.012
response to light stimulusGO:0009416460.012
ribonucleotide metabolic processGO:0009259270.012
meiotic cell cycle processGO:190304630.012
gland developmentGO:00487321430.012
cellular response to light stimulusGO:007148240.012
negative regulation of programmed cell deathGO:0043069580.012
embryonic skeletal system morphogenesisGO:0048704930.012
protein stabilizationGO:005082120.012
cytoskeleton dependent cytokinesisGO:006164030.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
interspecies interaction between organismsGO:004441940.012
cellular response to topologically incorrect proteinGO:003596720.012
response to hexoseGO:000974630.012
fin developmentGO:0033333770.012
regulation of rho protein signal transductionGO:003502320.012
regenerationGO:0031099910.012
exocytosisGO:000688710.012
regulation of synapse assemblyGO:005196330.012
positive regulation of neuron apoptotic processGO:004352510.012
nitric oxide biosynthetic processGO:000680920.012
response to inorganic substanceGO:0010035380.012
intracellular transportGO:0046907320.011
organelle assemblyGO:00709251100.011
negative regulation of developmental processGO:0051093650.011
cell cycle g1 s phase transitionGO:004484310.011

ppm1k disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.041
disease of anatomical entityDOID:700.031
cardiovascular system diseaseDOID:128700.026
musculoskeletal system diseaseDOID:1700.026
cardiomyopathyDOID:005070000.026
muscular diseaseDOID:008000000.026
intrinsic cardiomyopathyDOID:006003600.026
myopathyDOID:42300.026
heart diseaseDOID:11400.026
muscle tissue diseaseDOID:6600.026
nervous system diseaseDOID:86300.024
disease of cellular proliferationDOID:1456600.021
cancerDOID:16200.021
organ system cancerDOID:005068600.020
inherited metabolic disorderDOID:65500.012