IMP: Integrative Multi-species Prediction

Danio rerio

44 known processes

dlx5a

distal-less homeobox gene 5a

(Aliases: dlx4,zgc:101787,MGC101787)

Ensembl: ENSDARG00000042296
Entrez: 30569
ZFIN: ZDB-GENE-990415-49
UniProtKB: P50576

Process Predictions
Disease Predictions

dlx5a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organic substance biosynthetic process	GO:1901576	289	0.998	Human Mouse
response to abiotic stimulus	GO:0009628	122	0.997
auditory receptor cell fate specification	GO:0042667	2	0.997	Zebrafish
organic cyclic compound metabolic process	GO:1901360	301	0.996	Human Mouse
regionalization	GO:0003002	274	0.995
response to external stimulus	GO:0009605	264	0.988
regulation of biosynthetic process	GO:0009889	250	0.985	Human Mouse
biosynthetic process	GO:0009058	294	0.985	Human Mouse
cellular macromolecule metabolic process	GO:0044260	391	0.981	Human Mouse
regulation of transcription involved in cell fate commitment	GO:0060850	1	0.981
cellular aromatic compound metabolic process	GO:0006725	295	0.980	Human Mouse
nitrogen compound metabolic process	GO:0006807	319	0.979	Human Mouse
positive regulation of cellular biosynthetic process	GO:0031328	68	0.973	Human Mouse
cell morphogenesis involved in differentiation	GO:0000904	195	0.967	Mouse
central nervous system development	GO:0007417	387	0.964
specification of organ identity	GO:0010092	2	0.961
nucleobase containing compound biosynthetic process	GO:0034654	205	0.961	Human Mouse
cellular nitrogen compound metabolic process	GO:0034641	290	0.960	Human Mouse
sensory organ morphogenesis	GO:0090596	200	0.960	Zebrafish Mouse
embryonic organ development	GO:0048568	381	0.958	Zebrafish Mouse
regulation of cellular biosynthetic process	GO:0031326	245	0.954	Human Mouse
heterocycle biosynthetic process	GO:0018130	215	0.954	Human Mouse
inner ear receptor cell fate commitment	GO:0060120	4	0.950	Zebrafish
aromatic compound biosynthetic process	GO:0019438	217	0.950	Human Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.945	Human Mouse
regulation of transcription dna templated	GO:0006355	213	0.939	Human Mouse
positive regulation of gene expression	GO:0010628	71	0.932	Human Mouse
regulation of gene expression	GO:0010468	265	0.932	Human Mouse
skeletal system development	GO:0001501	181	0.923
positive regulation of stem cell proliferation	GO:2000648	1	0.922
positive regulation of metabolic process	GO:0009893	108	0.920	Human Mouse
inner ear development	GO:0048839	126	0.920	Zebrafish Mouse
generation of neurons	GO:0048699	385	0.918	Zebrafish Mouse
macromolecule biosynthetic process	GO:0009059	227	0.918	Human Mouse
mesenchymal cell proliferation	GO:0010463	1	0.915
regulation of nucleic acid templated transcription	GO:1903506	213	0.914	Human Mouse
regulation of multicellular organismal process	GO:0051239	277	0.913	Rat
auditory receptor cell fate commitment	GO:0009912	4	0.911	Zebrafish
morphogenesis of an epithelium	GO:0002009	333	0.909
neuron differentiation	GO:0030182	353	0.906	Zebrafish Mouse
regulation of rna metabolic process	GO:0051252	224	0.906	Human Mouse
regulation of wound healing	GO:0061041	2	0.904
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.902	Human Mouse
response to mechanical stimulus	GO:0009612	24	0.901
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.900	Human Mouse
cellular macromolecule biosynthetic process	GO:0034645	224	0.900	Human Mouse
ear development	GO:0043583	127	0.899	Zebrafish Mouse
inner ear morphogenesis	GO:0042472	63	0.893	Zebrafish Mouse
otic vesicle development	GO:0071599	42	0.891	Zebrafish
embryonic limb morphogenesis	GO:0030326	2	0.889	Mouse
stem cell proliferation	GO:0072089	4	0.878
mechanoreceptor differentiation	GO:0042490	37	0.876	Zebrafish
response to chemical	GO:0042221	320	0.875	Mouse
regulation of metabolic process	GO:0019222	359	0.873	Human Mouse
neuron projection guidance	GO:0097485	86	0.870	Mouse
cell surface receptor signaling pathway	GO:0007166	325	0.849	Mouse
positive regulation of biological process	GO:0048518	253	0.833	Human Mouse Rat
nucleobase containing compound metabolic process	GO:0006139	274	0.832	Human Mouse
negative regulation of biological process	GO:0048519	304	0.828
regulation of mesenchymal cell proliferation	GO:0010464	1	0.828
inner ear receptor cell differentiation	GO:0060113	29	0.823	Zebrafish
nucleic acid templated transcription	GO:0097659	181	0.821	Human Mouse
axon guidance	GO:0007411	86	0.816	Mouse
negative regulation of multicellular organismal process	GO:0051241	69	0.814
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.806
limb bud formation	GO:0060174	2	0.802
forebrain neuron fate commitment	GO:0021877	1	0.799
brain development	GO:0007420	293	0.793
medial fin morphogenesis	GO:0035141	14	0.789
neuron fate specification	GO:0048665	20	0.787	Zebrafish
regulation of nitrogen compound metabolic process	GO:0051171	251	0.780	Human Mouse
appendage morphogenesis	GO:0035107	56	0.775
positive regulation of cellular process	GO:0048522	201	0.773	Human Mouse Rat
regulation of rna biosynthetic process	GO:2001141	213	0.765	Human Mouse
embryonic organ morphogenesis	GO:0048562	274	0.763	Zebrafish Mouse
odontogenesis of dentin containing tooth	GO:0042475	1	0.763
cellular biosynthetic process	GO:0044249	286	0.762	Human Mouse
hair cell differentiation	GO:0035315	32	0.762	Zebrafish
regulation of stem cell proliferation	GO:0072091	2	0.762
neuron projection development	GO:0031175	180	0.757	Mouse
organic cyclic compound biosynthetic process	GO:1901362	223	0.756	Human Mouse
camera type eye morphogenesis	GO:0048593	108	0.730
heterocycle metabolic process	GO:0046483	290	0.728	Human Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.709	Human Mouse
rna metabolic process	GO:0016070	219	0.707	Human Mouse
forebrain neuron development	GO:0021884	7	0.704
regulation of cellular metabolic process	GO:0031323	320	0.701	Human Mouse
cell fate commitment	GO:0045165	99	0.698	Zebrafish
cell fate specification	GO:0001708	68	0.697	Zebrafish
neuron development	GO:0048666	262	0.695	Zebrafish Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.689	Human Mouse
positive regulation of macromolecule metabolic process	GO:0010604	93	0.685	Human Mouse
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.679	Human Mouse
organ formation	GO:0048645	17	0.673
blood vessel morphogenesis	GO:0048514	216	0.665
blood vessel development	GO:0001568	246	0.665
glial cell migration	GO:0008347	3	0.663
neuron fate commitment	GO:0048663	26	0.661	Zebrafish
embryonic skeletal system development	GO:0048706	97	0.658
medial fin development	GO:0033338	16	0.655
forebrain generation of neurons	GO:0021872	14	0.653
head development	GO:0060322	303	0.650	Mouse
gene expression	GO:0010467	252	0.648	Human Mouse
skin development	GO:0043588	54	0.647	Zebrafish
regulation of macromolecule biosynthetic process	GO:0010556	225	0.638	Human Mouse
endothelial cell proliferation	GO:0001935	11	0.626
regulation of primary metabolic process	GO:0080090	311	0.625	Human Mouse
neuron projection morphogenesis	GO:0048812	161	0.618	Mouse
determination of ventral identity	GO:0048264	21	0.612
skeletal system morphogenesis	GO:0048705	102	0.607	Mouse
appendage development	GO:0048736	80	0.602
dorsal ventral pattern formation	GO:0009953	125	0.597
glucocorticoid metabolic process	GO:0008211	2	0.594
negative regulation of transcription dna templated	GO:0045892	45	0.573
cellular response to organic substance	GO:0071310	105	0.565	Mouse
regulation of biological quality	GO:0065008	263	0.559
apoptotic process	GO:0006915	116	0.558
axonogenesis	GO:0007409	152	0.550	Mouse
otic vesicle morphogenesis	GO:0071600	34	0.545	Zebrafish
cell proliferation	GO:0008283	80	0.541	Human Mouse
positive regulation of nervous system development	GO:0051962	25	0.541
regulation of chondrocyte differentiation	GO:0032330	1	0.536
cranial suture morphogenesis	GO:0060363	1	0.526
fin morphogenesis	GO:0033334	53	0.525
limb development	GO:0060173	8	0.523	Mouse
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.522	Mouse
regulation of cell proliferation	GO:0042127	37	0.521	Mouse
olfactory placode morphogenesis	GO:0071699	7	0.515
regulation of endothelial cell proliferation	GO:0001936	1	0.509
epithelial cell differentiation	GO:0030855	116	0.509	Zebrafish Mouse
gliogenesis	GO:0042063	45	0.504
forebrain development	GO:0030900	96	0.499
cartilage development	GO:0051216	96	0.496
hematopoietic or lymphoid organ development	GO:0048534	191	0.496
vasculature development	GO:0001944	278	0.484
negative regulation of macromolecule metabolic process	GO:0010605	76	0.481
proximal distal pattern formation	GO:0009954	1	0.478
chondrocyte development	GO:0002063	4	0.473
negative regulation of signal transduction in absence of ligand	GO:1901099	1	0.468
nucleic acid metabolic process	GO:0090304	244	0.467	Human Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.463
gland development	GO:0048732	143	0.462
stem cell maintenance	GO:0019827	4	0.462
transcription dna templated	GO:0006351	181	0.460	Human Mouse
negative regulation of biosynthetic process	GO:0009890	55	0.459
positive regulation of biosynthetic process	GO:0009891	68	0.458	Human Mouse
positive regulation of mesenchymal cell proliferation	GO:0002053	1	0.452
rna biosynthetic process	GO:0032774	181	0.442	Human Mouse
regulation of developmental process	GO:0050793	247	0.441	Rat
protein import	GO:0017038	3	0.435
positive regulation of neurogenesis	GO:0050769	24	0.433
homeostatic process	GO:0042592	142	0.427
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.424
morphogenesis of a branching structure	GO:0001763	21	0.423
cellular component morphogenesis	GO:0032989	336	0.421	Mouse
epithelial cell migration	GO:0010631	25	0.420
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.416
signal transduction	GO:0007165	455	0.411	Mouse
notochord development	GO:0030903	54	0.407
regulation of epithelial cell proliferation	GO:0050678	3	0.396	Mouse
ear morphogenesis	GO:0042471	64	0.393	Zebrafish Mouse
determination of dorsal ventral asymmetry	GO:0048262	34	0.391
digestive tract development	GO:0048565	265	0.385
cell part morphogenesis	GO:0032990	246	0.383	Mouse
regulation of macromolecule metabolic process	GO:0060255	317	0.381	Human Mouse
regulation of neurogenesis	GO:0050767	87	0.373
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.372
negative regulation of gene expression	GO:0010629	65	0.371
negative regulation of embryonic development	GO:0045992	11	0.364
posterior lateral line neuromast primordium migration	GO:0048920	12	0.360
positive regulation of cell proliferation	GO:0008284	15	0.357	Mouse
neural nucleus development	GO:0048857	15	0.348
regulation of signal transduction	GO:0009966	225	0.347	Mouse
negative regulation of cellular biosynthetic process	GO:0031327	55	0.346
axon development	GO:0061564	166	0.333	Mouse
angiogenesis	GO:0001525	158	0.332
system process	GO:0003008	185	0.323
cell migration	GO:0016477	237	0.320
catecholamine biosynthetic process	GO:0042423	2	0.319
negative regulation of cellular metabolic process	GO:0031324	77	0.318
connective tissue development	GO:0061448	99	0.312
small molecule metabolic process	GO:0044281	77	0.312
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	1	0.310
regulation of multicellular organismal development	GO:2000026	223	0.306
morphogenesis of an epithelial fold	GO:0060571	1	0.304
death	GO:0016265	121	0.299
embryonic appendage morphogenesis	GO:0035113	30	0.298	Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.292	Mouse
neuron death	GO:0070997	21	0.291
otic vesicle formation	GO:0030916	27	0.290	Zebrafish
heart looping	GO:0001947	94	0.288
regulation of myotube differentiation	GO:0010830	2	0.283
heart formation	GO:0060914	13	0.281
limb morphogenesis	GO:0035108	7	0.278	Mouse
negative regulation of muscle tissue development	GO:1901862	2	0.275
behavior	GO:0007610	74	0.270
positive regulation of programmed cell death	GO:0043068	29	0.267
oligodendrocyte differentiation	GO:0048709	23	0.262
response to stress	GO:0006950	263	0.258
transcription from rna polymerase ii promoter	GO:0006366	80	0.253	Mouse
renal system development	GO:0072001	94	0.252
bmp signaling pathway	GO:0030509	52	0.251	Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.250
cellular component movement	GO:0006928	335	0.246	Mouse
pectoral fin development	GO:0033339	50	0.245
chordate embryonic development	GO:0043009	271	0.240
developmental growth	GO:0048589	166	0.240
olfactory bulb development	GO:0021772	4	0.238
negative regulation of striated muscle tissue development	GO:0045843	2	0.236
immune system process	GO:0002376	241	0.236
negative regulation of developmental process	GO:0051093	65	0.229
skeletal muscle tissue development	GO:0007519	67	0.228
positive regulation of response to stimulus	GO:0048584	80	0.227	Mouse
adenohypophysis development	GO:0021984	15	0.222
cellular ketone metabolic process	GO:0042180	11	0.219
positive regulation of rna metabolic process	GO:0051254	59	0.215	Human Mouse
camera type eye development	GO:0043010	222	0.214	Zebrafish
specification of symmetry	GO:0009799	204	0.212
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.207	Mouse
neuron fate determination	GO:0048664	2	0.205
cellular response to chemical stimulus	GO:0070887	157	0.204	Mouse
determination of bilateral symmetry	GO:0009855	204	0.204
telencephalon development	GO:0021537	14	0.203
eye morphogenesis	GO:0048592	144	0.201
tissue remodeling	GO:0048771	4	0.196
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	1	0.191
positive regulation of apoptotic process	GO:0043065	29	0.190
trigeminal nerve development	GO:0021559	3	0.190	Zebrafish
regulation of cell development	GO:0060284	100	0.188
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.187	Human Mouse
glial cell fate specification	GO:0021780	4	0.187
cell maturation	GO:0048469	23	0.184
cellular response to endogenous stimulus	GO:0071495	68	0.182	Mouse
stem cell differentiation	GO:0048863	117	0.181
negative regulation of programmed cell death	GO:0043069	58	0.177
response to immobilization stress	GO:0035902	1	0.175
negative regulation of metabolic process	GO:0009892	86	0.171
digestive system development	GO:0055123	289	0.168
positive regulation of cellular component biogenesis	GO:0044089	3	0.167
cellular response to steroid hormone stimulus	GO:0071383	31	0.167
positive regulation of neuron differentiation	GO:0045666	12	0.166
posterior lateral line development	GO:0048916	38	0.166
protein import into nucleus	GO:0006606	3	0.166
regulation of nervous system development	GO:0051960	90	0.163
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.159
negative regulation of rna metabolic process	GO:0051253	48	0.158
response to oxygen levels	GO:0070482	25	0.157
embryonic camera type eye development	GO:0031076	29	0.155
neuron apoptotic process	GO:0051402	20	0.155
positive regulation of cellular metabolic process	GO:0031325	94	0.153	Human Mouse
skeletal muscle organ development	GO:0060538	78	0.153
positive regulation of signaling	GO:0023056	56	0.153	Mouse
cartilage condensation	GO:0001502	3	0.149
regulation of signaling	GO:0023051	235	0.149	Mouse
positive regulation of transcription dna templated	GO:0045893	57	0.147	Human Mouse
regulation of binding	GO:0051098	3	0.147
positive regulation of cell motility	GO:2000147	11	0.147
muscle structure development	GO:0061061	196	0.146
positive regulation of developmental process	GO:0051094	50	0.146	Rat
phenol containing compound biosynthetic process	GO:0046189	4	0.146
single organism metabolic process	GO:0044710	217	0.144
regulation of cell death	GO:0010941	103	0.143
cellular response to fibroblast growth factor stimulus	GO:0044344	22	0.143
response to organic substance	GO:0010033	153	0.142	Mouse
collagen biosynthetic process	GO:0032964	2	0.139
notch signaling pathway	GO:0007219	35	0.139
nephron tubule morphogenesis	GO:0072078	1	0.137
regulation of programmed cell death	GO:0043067	101	0.136
regulation of cell communication	GO:0010646	232	0.135	Mouse
negative regulation of cellular process	GO:0048523	283	0.134
heart development	GO:0007507	313	0.134
palate development	GO:0060021	8	0.134	Mouse
determination of left right symmetry	GO:0007368	179	0.133
response to corticosteroid	GO:0031960	1	0.132
phosphorus metabolic process	GO:0006793	109	0.132
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.132	Mouse
renal tubule morphogenesis	GO:0061333	1	0.131
muscle organ development	GO:0007517	101	0.131
sensory organ development	GO:0007423	393	0.130	Zebrafish Mouse
localization of cell	GO:0051674	244	0.130
epidermis development	GO:0008544	48	0.129	Zebrafish
heart jogging	GO:0003146	40	0.128
positive regulation of cell cycle	GO:0045787	3	0.127
fin development	GO:0033333	77	0.125
catechol containing compound biosynthetic process	GO:0009713	2	0.124
muscle tissue development	GO:0060537	110	0.123
response to oxygen containing compound	GO:1901700	55	0.122
regulation of inner ear receptor cell differentiation	GO:2000980	1	0.120
locus ceruleus development	GO:0021703	3	0.118
circulatory system process	GO:0003013	87	0.117
oligodendrocyte cell fate specification	GO:0021778	4	0.116
negative regulation of cell differentiation	GO:0045596	46	0.116
outflow tract morphogenesis	GO:0003151	1	0.116
response to hormone	GO:0009725	48	0.116
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.113
somitogenesis	GO:0001756	87	0.113
anal fin development	GO:0033335	1	0.112
response to glucocorticoid	GO:0051384	1	0.111
negative regulation of nervous system development	GO:0051961	22	0.110
eye development	GO:0001654	277	0.110	Zebrafish
ectodermal placode morphogenesis	GO:0071697	32	0.109
positive regulation of cell differentiation	GO:0045597	30	0.106	Rat
positive regulation of notch signaling pathway	GO:0045747	3	0.104
positive regulation of endothelial cell proliferation	GO:0001938	1	0.104
positive regulation of muscle organ development	GO:0048636	1	0.103
negative regulation of endothelial cell migration	GO:0010596	1	0.103
sympathetic nervous system development	GO:0048485	3	0.102
endocrine system development	GO:0035270	65	0.101	Zebrafish
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.098
dopaminergic neuron differentiation	GO:0071542	14	0.098
regulation of notch signaling pathway	GO:0008593	16	0.096
locomotory behavior	GO:0007626	34	0.095
regulation of axon extension	GO:0030516	24	0.094
cell morphogenesis	GO:0000902	289	0.093	Mouse
otolith development	GO:0048840	32	0.092
negative regulation of signaling	GO:0023057	96	0.092
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.092
positive regulation of epithelial cell proliferation	GO:0050679	1	0.092	Mouse
positive regulation of epithelial cell migration	GO:0010634	2	0.091
kidney development	GO:0001822	92	0.090
carbohydrate derivative metabolic process	GO:1901135	61	0.087
hemopoiesis	GO:0030097	183	0.087
amine metabolic process	GO:0009308	2	0.087
odontogenesis	GO:0042476	9	0.087
phosphate containing compound metabolic process	GO:0006796	108	0.086
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.086
regulation of oligodendrocyte differentiation	GO:0048713	1	0.086
embryonic heart tube development	GO:0035050	133	0.086
response to external biotic stimulus	GO:0043207	97	0.085
regulation of cell differentiation	GO:0045595	142	0.085	Rat
sprouting angiogenesis	GO:0002040	53	0.085
response to lipid	GO:0033993	60	0.085
embryonic viscerocranium morphogenesis	GO:0048703	52	0.084
innervation	GO:0060384	3	0.084
protein modification process	GO:0036211	100	0.082
organonitrogen compound metabolic process	GO:1901564	74	0.082
tissue migration	GO:0090130	37	0.081
regulation of glial cell differentiation	GO:0045685	4	0.081
negative regulation of epithelial cell proliferation	GO:0050680	1	0.080
craniofacial suture morphogenesis	GO:0097094	2	0.080
ectodermal placode formation	GO:0060788	26	0.079	Zebrafish
regulation of tube size	GO:0035150	2	0.079
regulation of cellular amine metabolic process	GO:0033238	0	0.079
nephron morphogenesis	GO:0072028	2	0.078
ameboidal type cell migration	GO:0001667	143	0.078
single organism behavior	GO:0044708	24	0.077
negative regulation of mitosis	GO:0045839	3	0.077
signal transduction in absence of ligand	GO:0038034	1	0.077
retinal ganglion cell axon guidance	GO:0031290	35	0.077
protein targeting to nucleus	GO:0044744	3	0.076
response to decreased oxygen levels	GO:0036293	25	0.076
positive regulation of cell communication	GO:0010647	56	0.075	Mouse
positive regulation of smoothened signaling pathway	GO:0045880	5	0.075
stem cell development	GO:0048864	82	0.075
pituitary gland development	GO:0021983	16	0.075
growth	GO:0040007	174	0.074
posterior lateral line system development	GO:0048915	46	0.074
bone development	GO:0060348	14	0.074	Mouse
epithelial cell proliferation	GO:0050673	17	0.074	Mouse
entrainment of circadian clock	GO:0009649	2	0.074
regulation of skeletal muscle tissue development	GO:0048641	4	0.074
vestibular receptor cell development	GO:0060118	3	0.073
regulation of apoptotic process	GO:0042981	98	0.073
response to endogenous stimulus	GO:0009719	83	0.073	Mouse
programmed cell death	GO:0012501	119	0.073
cell cycle	GO:0007049	93	0.072
muscle cell development	GO:0055001	115	0.072
synaptic growth at neuromuscular junction	GO:0051124	2	0.072
negative regulation of apoptotic process	GO:0043066	55	0.070
immune system development	GO:0002520	191	0.070
urogenital system development	GO:0001655	97	0.070
cell type specific apoptotic process	GO:0097285	22	0.069
embryonic heart tube morphogenesis	GO:0003143	108	0.068
stem cell division	GO:0017145	1	0.068
positive regulation of cell adhesion	GO:0045785	1	0.068
auditory receptor cell fate determination	GO:0042668	2	0.068
myeloid cell differentiation	GO:0030099	86	0.067
positive regulation of cell death	GO:0010942	29	0.067
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	1	0.067
erk1 and erk2 cascade	GO:0070371	4	0.066
response to steroid hormone	GO:0048545	35	0.066
negative regulation of epithelial cell migration	GO:0010633	1	0.066
regulation of mechanoreceptor differentiation	GO:0045631	1	0.066
retina development in camera type eye	GO:0060041	146	0.065
patterning of blood vessels	GO:0001569	15	0.065
nucleocytoplasmic transport	GO:0006913	4	0.065
wound healing	GO:0042060	90	0.065
chemosensory behavior	GO:0007635	1	0.065
cartilage morphogenesis	GO:0060536	13	0.063
cell motility	GO:0048870	244	0.063
negative regulation of neuron differentiation	GO:0045665	10	0.062
tissue regeneration	GO:0042246	74	0.062
regulation of gliogenesis	GO:0014013	6	0.061
taxis	GO:0042330	109	0.061	Mouse
organic acid metabolic process	GO:0006082	31	0.060
cellular response to growth factor stimulus	GO:0071363	39	0.059	Mouse
epithelial tube morphogenesis	GO:0060562	148	0.059
regulation of anatomical structure morphogenesis	GO:0022603	130	0.059
negative regulation of muscle cell differentiation	GO:0051148	1	0.059
cellular response to lipid	GO:0071396	39	0.058
larval development	GO:0002164	2	0.057
heart morphogenesis	GO:0003007	156	0.057
positive regulation of multicellular organismal process	GO:0051240	52	0.057	Rat
response to growth factor	GO:0070848	39	0.057	Mouse
response to biotic stimulus	GO:0009607	97	0.057
regulation of cell fate specification	GO:0042659	20	0.056
embryonic digestive tract morphogenesis	GO:0048557	3	0.056
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.056
ventral spinal cord development	GO:0021517	35	0.055
somatic stem cell maintenance	GO:0035019	1	0.055
auditory receptor cell differentiation	GO:0042491	15	0.055	Zebrafish
nephron epithelium morphogenesis	GO:0072088	1	0.055
meiotic nuclear division	GO:0007126	4	0.055
glycosaminoglycan metabolic process	GO:0030203	9	0.055
endocardial cushion morphogenesis	GO:0003203	3	0.054
embryonic skeletal joint development	GO:0072498	3	0.054
kupffer s vesicle development	GO:0070121	50	0.053
positive regulation of cellular protein metabolic process	GO:0032270	22	0.053
pharyngeal system development	GO:0060037	18	0.053
negative regulation of granulocyte chemotaxis	GO:0071623	3	0.053
leukocyte homeostasis	GO:0001776	2	0.052
myotube differentiation	GO:0014902	45	0.052
regulation of catalytic activity	GO:0050790	55	0.052
negative regulation of striated muscle cell differentiation	GO:0051154	1	0.052
dendrite development	GO:0016358	9	0.051
protein complex subunit organization	GO:0071822	46	0.051
positive regulation of cell development	GO:0010720	25	0.050
regulation of reproductive process	GO:2000241	4	0.050
spinal cord development	GO:0021510	46	0.050
regulation of protein ubiquitination	GO:0031396	3	0.050
exocrine pancreas development	GO:0031017	28	0.050
regulation of epithelial cell migration	GO:0010632	5	0.050
positive regulation of hydrolase activity	GO:0051345	13	0.050
smoothened signaling pathway	GO:0007224	30	0.050
response to wounding	GO:0009611	116	0.050
central nervous system neuron development	GO:0021954	29	0.050
single organism nuclear import	GO:1902593	3	0.049
atrial ventricular junction remodeling	GO:0003294	2	0.049
carboxylic acid metabolic process	GO:0019752	22	0.049
positive regulation of cell migration	GO:0030335	11	0.049
regulation of cell proliferation involved in heart morphogenesis	GO:2000136	2	0.049
forebrain regionalization	GO:0021871	4	0.049
regulation of neuron apoptotic process	GO:0043523	17	0.049
response to bacterium	GO:0009617	58	0.049
cellular amine metabolic process	GO:0044106	2	0.049
regulation of neuron differentiation	GO:0045664	56	0.048
axon extension involved in axon guidance	GO:0048846	10	0.048
heart field specification	GO:0003128	1	0.048
cell migration involved in gastrulation	GO:0042074	79	0.048
ventricular cardiac muscle cell development	GO:0055015	5	0.048
determination of heart left right asymmetry	GO:0061371	117	0.047
gabaergic neuron differentiation	GO:0097154	2	0.046
regulation of erk1 and erk2 cascade	GO:0070372	4	0.046
phagocytosis	GO:0006909	3	0.046
anterior posterior pattern specification	GO:0009952	152	0.046
negative regulation of response to stimulus	GO:0048585	104	0.045
extracellular structure organization	GO:0043062	27	0.045
astrocyte differentiation	GO:0048708	1	0.045
neuron projection extension	GO:1990138	45	0.045
myotome development	GO:0061055	1	0.045
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.045
endodermal cell fate determination	GO:0007493	2	0.045
peripheral nervous system development	GO:0007422	55	0.045
embryonic camera type eye morphogenesis	GO:0048596	19	0.045
neuroblast proliferation	GO:0007405	2	0.044
establishment of protein localization to organelle	GO:0072594	4	0.044
regulation of multicellular organism growth	GO:0040014	4	0.043
protein localization to nucleus	GO:0034504	3	0.043
collagen fibril organization	GO:0030199	1	0.043
neural tube development	GO:0021915	62	0.043
defense response	GO:0006952	47	0.043
smooth muscle tissue development	GO:0048745	1	0.043
axonogenesis involved in innervation	GO:0060385	1	0.043
response to fibroblast growth factor	GO:0071774	22	0.043
axon extension	GO:0048675	45	0.043
forebrain cell migration	GO:0021885	1	0.043
ras protein signal transduction	GO:0007265	7	0.043
cardiac chamber development	GO:0003205	19	0.042
regulation of blood coagulation	GO:0030193	1	0.042
retina morphogenesis in camera type eye	GO:0060042	79	0.042
rhythmic process	GO:0048511	21	0.042
negative regulation of cell communication	GO:0010648	96	0.042
cardiac chamber formation	GO:0003207	4	0.042
dopamine biosynthetic process	GO:0042416	2	0.041
regulation of cell fate commitment	GO:0010453	22	0.041
tube morphogenesis	GO:0035239	349	0.041
gamete generation	GO:0007276	33	0.041
peripheral nervous system neuron differentiation	GO:0048934	28	0.040
detection of abiotic stimulus	GO:0009582	24	0.040
regulation of neuron death	GO:1901214	18	0.040
axis specification	GO:0009798	43	0.040
regulation of skeletal muscle fiber development	GO:0048742	2	0.040

dlx5a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
connective tissue disease	DOID:65	0.771
musculoskeletal system disease	DOID:17	0.771
bone development disease	DOID:0080006	0.771
bone disease	DOID:0080001	0.771
disease of anatomical entity	DOID:7	0.771
osteochondrodysplasia	DOID:2256	0.213
dysostosis	DOID:1934	0.127

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