Danio rerio

0 known processes

wfs1b

Wolfram syndrome 1b (wolframin)

(Aliases: im:7150991)

wfs1b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.084
agingGO:000756820.055
positive regulation of transportGO:005105020.049
multicellular organism growthGO:003526440.040
generation of neuronsGO:00486993850.032
cognitionGO:005089010.032
regulation of multicellular organism growthGO:004001440.032
establishment of protein localization to organelleGO:007259440.032
cellular amine metabolic processGO:004410620.031
golgi vesicle transportGO:004819330.031
regulation of establishment of protein localizationGO:007020140.031
amine metabolic processGO:000930820.030
synaptic growth at neuromuscular junctionGO:005112420.030
phagocytosisGO:000690930.030
maintenance of locationGO:005123540.030
sensory organ developmentGO:00074233930.029
organelle fusionGO:004828430.029
guanosine containing compound catabolic processGO:190106920.028
cellular protein catabolic processGO:004425740.028
proteolysis involved in cellular protein catabolic processGO:005160330.028
modification dependent protein catabolic processGO:001994130.028
neuron differentiationGO:00301823530.028
ubiquitin dependent protein catabolic processGO:000651130.028
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.027
meiotic nuclear divisionGO:000712640.027
negative regulation of protein phosphorylationGO:000193340.027
protein localization to nucleusGO:003450430.027
modification dependent macromolecule catabolic processGO:004363230.027
cellular component movementGO:00069283350.027
mitochondrion organizationGO:000700540.027
cellular nitrogen compound metabolic processGO:00346412900.027
positive regulation of cell cycleGO:004578730.027
gtp catabolic processGO:000618420.026
cellular macromolecule metabolic processGO:00442603910.026
stem cell proliferationGO:007208940.026
regulation of protein transportGO:005122330.026
gtp metabolic processGO:004603940.026
positive regulation of catabolic processGO:000989640.026
positive regulation of cellular component biogenesisGO:004408930.026
nitrogen compound metabolic processGO:00068073190.026
signal transductionGO:00071654550.026
cellular response to external stimulusGO:007149620.026
cellular component morphogenesisGO:00329893360.026
cellular ketone metabolic processGO:0042180110.025
positive regulation of cellular catabolic processGO:003133130.025
regulation of reproductive processGO:200024140.025
neurotransmitter transportGO:000683620.025
guanosine containing compound metabolic processGO:190106840.025
membrane fusionGO:006102520.025
single organism metabolic processGO:00447102170.025
adult behaviorGO:003053420.024
heterocycle metabolic processGO:00464832900.024
regulation of synapse organizationGO:005080730.024
nuclear transportGO:005116940.024
single organism membrane fusionGO:004480120.024
organic substance biosynthetic processGO:19015762890.024
regulation of cytoplasmic transportGO:190364940.024
extrinsic apoptotic signaling pathwayGO:009719130.024
cytokinesisGO:000091030.024
cell projection morphogenesisGO:00488582440.024
meiotic cell cycle processGO:190304630.024
response to monosaccharideGO:003428430.024
regulation of synapse assemblyGO:005196330.023
compound eye developmentGO:004874920.023
regulation of bindingGO:005109830.023
morphogenesis of an epitheliumGO:00020093330.023
nucleocytoplasmic transportGO:000691340.023
cellular biosynthetic processGO:00442492860.023
response to chemicalGO:00422213200.023
regulation of intracellular protein transportGO:003315730.023
biosynthetic processGO:00090582940.023
proteasomal protein catabolic processGO:001049820.023
stem cell maintenanceGO:001982740.023
neuron developmentGO:00486662620.023
regulation of mrna processingGO:005068430.022
protein targeting to nucleusGO:004474430.022
regulation of metal ion transportGO:001095940.022
regulation of cellular amino acid metabolic processGO:000652100.022
negative regulation of protein kinase activityGO:000646940.022
protein localization to plasma membraneGO:007265910.022
lipid storageGO:001991510.022
neuron neuron synaptic transmissionGO:000727010.022
protein importGO:001703830.022
organic cyclic compound metabolic processGO:19013603010.022
regulation of synaptic growth at neuromuscular junctionGO:000858210.022
regulation of cellular amine metabolic processGO:003323800.022
cell projection organizationGO:00300302840.022
eye developmentGO:00016542770.021
small molecule metabolic processGO:0044281770.021
rna localizationGO:000640340.021
exocytosisGO:000688710.021
regulation of primary metabolic processGO:00800903110.021
autophagyGO:000691440.021
ribonucleoside monophosphate catabolic processGO:000915840.021
cellular aromatic compound metabolic processGO:00067252950.021
response to carbohydrateGO:000974330.021
neurotransmitter secretionGO:000726920.021
regulation of metabolic processGO:00192223590.021
carboxylic acid metabolic processGO:0019752220.021
nuclear importGO:005117030.021
single organism nuclear importGO:190259330.021
cell substrate adhesionGO:003158940.021
endosomal transportGO:001619720.021
regulation of protein complex assemblyGO:004325430.021
oxoacid metabolic processGO:0043436310.021
cell morphogenesisGO:00009022890.021
establishment of protein localization to plasma membraneGO:009000210.021
regulation of signalingGO:00230512350.021
regulation of cellular ketone metabolic processGO:001056570.021
fertilizationGO:000956630.021
regulation of neurotransmitter transportGO:005158810.021
rna metabolic processGO:00160702190.021
atp catabolic processGO:000620040.021
cellular nitrogen compound biosynthetic processGO:00442712180.021
nucleobase containing compound metabolic processGO:00061392740.021
regulation of macromolecule metabolic processGO:00602553170.020
cellular carbohydrate metabolic processGO:004426240.020
cellular response to extracellular stimulusGO:003166820.020
organelle organizationGO:00069962270.020
cellular amino acid metabolic processGO:000652070.020
regulation of nucleoside metabolic processGO:000911820.020
negative regulation of kinase activityGO:003367340.020
regulation of purine nucleotide catabolic processGO:003312120.020
regulation of cytokine productionGO:000181730.020
regulation of nucleocytoplasmic transportGO:004682220.020
gene expressionGO:00104672520.020
purine ribonucleoside monophosphate catabolic processGO:000916940.020
regulation of peptidyl tyrosine phosphorylationGO:005073010.020
female sex differentiationGO:004666040.020
cytoskeleton dependent cytokinesisGO:006164030.020
organonitrogen compound metabolic processGO:1901564740.020
tube morphogenesisGO:00352393490.020
negative regulation of biological processGO:00485193040.019
regulation of meiotic cell cycleGO:005144510.019
nucleoside monophosphate catabolic processGO:000912540.019
nucleic acid metabolic processGO:00903042440.019
embryonic organ developmentGO:00485683810.019
cellular respirationGO:004533330.019
regulation of multicellular organismal processGO:00512392770.019
digestive system developmentGO:00551232890.019
regulation of synaptic plasticityGO:004816710.019
lipid catabolic processGO:001604240.019
cell part morphogenesisGO:00329902460.019
nucleobase containing compound biosynthetic processGO:00346542050.019
transportGO:00068102200.019
regulation of protein targetingGO:190353320.019
organic acid catabolic processGO:001605430.019
regulation of biological qualityGO:00650082630.019
regulation of cell activationGO:005086510.019
positive regulation of secretionGO:005104710.019
regulation of biosynthetic processGO:00098892500.019
regulation of cell shapeGO:000836010.019
positive regulation of cellular amino acid metabolic processGO:004576400.019
regulation of cellular biosynthetic processGO:00313262450.019
aromatic compound biosynthetic processGO:00194382170.018
purine nucleoside monophosphate catabolic processGO:000912840.018
positive regulation of cellular amine metabolic processGO:003324000.018
regulation of protein localization to nucleusGO:190018020.018
cytoplasm organizationGO:000702840.018
single organism localizationGO:19025782250.018
organic acid metabolic processGO:0006082310.018
head developmentGO:00603223030.018
single fertilizationGO:000733830.018
chemosensory behaviorGO:000763510.018
regulation of nucleotide catabolic processGO:003081120.018
cellular response to nutrient levelsGO:003166920.018
positive regulation of protein complex assemblyGO:003133420.018
cell surface receptor signaling pathwayGO:00071663250.018
alcohol biosynthetic processGO:004616520.018
cell migrationGO:00164772370.018
stem cell divisionGO:001714510.018
establishment of localizationGO:00512342440.018
protein import into nucleusGO:000660630.018
heterocycle biosynthetic processGO:00181302150.018
cell motilityGO:00488702440.018
central nervous system developmentGO:00074173870.018
regulation of cellular metabolic processGO:00313233200.018
cellular component disassemblyGO:002241110.018
negative regulation of cellular processGO:00485232830.018
adherens junction organizationGO:003433240.017
vasculature developmentGO:00019442780.017
regulation of cell communicationGO:00106462320.017
macromolecule biosynthetic processGO:00090592270.017
digestive tract morphogenesisGO:00485462310.017
single organism transportGO:00447652060.017
transcription dna templatedGO:00063511810.017
positive regulation of purine nucleotide catabolic processGO:003312310.017
response to external stimulusGO:00096052640.017
positive regulation of biological processGO:00485182530.017
sequestering of metal ionGO:005123830.017
system processGO:00030081850.017
positive regulation of secretion by cellGO:190353210.017
er to golgi vesicle mediated transportGO:000688810.017
response to glucoseGO:000974930.017
response to drugGO:004249330.017
digestive tract developmentGO:00485652650.017
cellular component biogenesisGO:00440851780.017
lateral inhibitionGO:004633110.017
cellular macromolecule biosynthetic processGO:00346452240.017
cellular response to starvationGO:000926710.017
protein acetylationGO:000647320.017
neuroblast proliferationGO:000740520.017
organic cyclic compound biosynthetic processGO:19013622230.017
response to hexoseGO:000974630.017
regulation of signal transductionGO:00099662250.017
muscle structure developmentGO:00610611960.017
small molecule catabolic processGO:004428230.017
centrosome organizationGO:005129710.017
regulation of dendrite developmentGO:005077330.017
regulation of extrinsic apoptotic signaling pathwayGO:200123630.017
spermatid differentiationGO:004851520.016
regulation of gtp catabolic processGO:003312420.016
regulation of jak stat cascadeGO:004642530.016
synaptic vesicle transportGO:004848910.016
establishment of synaptic vesicle localizationGO:009748010.016
positive regulation of nucleotide catabolic processGO:003081310.016
locomotionGO:00400113130.016
protein acylationGO:004354330.016
axonogenesisGO:00074091520.016
camera type eye developmentGO:00430102220.016
regulation of stem cell proliferationGO:007209120.016
peptidyl serine phosphorylationGO:001810510.016
regulation of gtpase activityGO:004308720.016
regulation of protein import into nucleusGO:004230620.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
spermatid developmentGO:000728620.016
microtubule organizing center organizationGO:003102310.016
positive regulation of cytosolic calcium ion concentrationGO:000720440.016
regulation of response to stimulusGO:00485832690.016
regulation of neurotransmitter secretionGO:004692810.016
regulation of nitrogen compound metabolic processGO:00511712510.016
sensory organ morphogenesisGO:00905962000.016
positive regulation of gtp catabolic processGO:003312610.016
peptidyl serine modificationGO:001820920.016
internal protein amino acid acetylationGO:000647520.016
blood vessel developmentGO:00015682460.015
intracellular mrna localizationGO:000829810.015
regulation of developmental processGO:00507932470.015
actin polymerization or depolymerizationGO:000815420.015
positive regulation of nucleoside metabolic processGO:004597910.015
macromolecular complex disassemblyGO:003298410.015
immune system processGO:00023762410.015
regulation of neural precursor cell proliferationGO:200017730.015
post golgi vesicle mediated transportGO:000689210.015
cell cycle g1 s phase transitionGO:004484310.015
regulation of macromolecule biosynthetic processGO:00105562250.015
regulation of gene expressionGO:00104682650.015
peptide transportGO:001583310.015
regulation of sequestering of calcium ionGO:005128240.015
negative regulation of intracellular transportGO:003238730.015
negative regulation of protein transportGO:005122430.015
positive regulation of gtpase activityGO:004354710.015
sequestering of calcium ionGO:005120830.015
gastrulationGO:00073692080.015
chordate embryonic developmentGO:00430092710.015
glucose homeostasisGO:004259310.015
regulation of protein ubiquitinationGO:003139630.015
regulation of nucleobase containing compound metabolic processGO:00192192500.015
response to stressGO:00069502630.015
regulation of multicellular organismal developmentGO:20000262230.015
protein complex disassemblyGO:004324110.015
primary neural tube formationGO:001402010.015
negative regulation of catabolic processGO:000989530.015
tissue remodelingGO:004877140.015
negative regulation of sequestering of calcium ionGO:005128340.014
peptidyl lysine acetylationGO:001839420.014
internal peptidyl lysine acetylationGO:001839320.014
negative regulation of cytoplasmic transportGO:190365020.014
meiotic chromosome segregationGO:004513230.014
regulation of erk1 and erk2 cascadeGO:007037240.014
protein metabolic processGO:00195381830.014
specification of symmetryGO:00097992040.014
germ line stem cell maintenanceGO:003071820.014
protein polyubiquitinationGO:000020940.014
neuron projection developmentGO:00311751800.014
secondary metabolic processGO:001974830.014
positive regulation of cytoskeleton organizationGO:005149530.014
symbiosis encompassing mutualism through parasitismGO:004440340.014
amino acid transportGO:000686520.014
neuron projection morphogenesisGO:00488121610.014
negative regulation of synapse assemblyGO:005196420.014
nucleic acid templated transcriptionGO:00976591810.014
regulation of cellular macromolecule biosynthetic processGO:20001122220.014
regulation of mrna splicing via spliceosomeGO:004802430.014
cellular amide metabolic processGO:004360340.014
protein secretionGO:000930610.014
oocyte anterior posterior axis specificationGO:000731440.014
rna biosynthetic processGO:00327741810.014
blood vessel morphogenesisGO:00485142160.014
homeostatic processGO:00425921420.014
regulation of protein catabolic processGO:004217610.014
cell matrix adhesionGO:000716040.014
cell morphogenesis involved in differentiationGO:00009041950.014
regulation of transporter activityGO:003240920.014
carbohydrate homeostasisGO:003350010.014
i kappab kinase nf kappab signalingGO:000724940.014
interspecies interaction between organismsGO:004441940.014
carboxylic acid catabolic processGO:004639530.014
positive regulation of cell activationGO:005086710.014
cellular response to chemical stimulusGO:00708871570.013
response to nutrientGO:000758430.013
maternal determination of anterior posterior axis embryoGO:000835840.013
erk1 and erk2 cascadeGO:007037140.013
synaptic vesicle localizationGO:009747910.013
negative regulation of protein serine threonine kinase activityGO:007190120.013
membrane invaginationGO:001032410.013
cytosolic calcium ion transportGO:006040130.013
positive regulation of cytokine productionGO:000181920.013
regulation of i kappab kinase nf kappab signalingGO:004312240.013
sleepGO:003043110.013
positive regulation of apoptotic signaling pathwayGO:200123510.013
regulation of rna metabolic processGO:00512522240.013
regulation of ion transmembrane transporter activityGO:003241220.013
locomotor rhythmGO:004547530.013
response to uvGO:000941130.013
regulation of nucleic acid templated transcriptionGO:19035062130.013
axon developmentGO:00615641660.013
mitochondrial transportGO:000683920.013
somatic muscle developmentGO:000752540.013
protein homooligomerizationGO:005126030.013
regulation of calcium ion transportGO:005192420.013
positive regulation of dna metabolic processGO:005105410.013
heart developmentGO:00075073130.013
regulation of inflammatory responseGO:005072720.013
fatty acid catabolic processGO:000906210.013
response to topologically incorrect proteinGO:003596620.013
cilium morphogenesisGO:0060271850.013
g1 s transition of mitotic cell cycleGO:000008210.013
regionalizationGO:00030022740.013
hormone secretionGO:004687920.013
centrosome cycleGO:000709810.013
pole plasm assemblyGO:000731540.013
single organism organelle organizationGO:19025891990.013
cellular response to molecule of bacterial originGO:007121930.013
carbohydrate biosynthetic processGO:001605110.013
cell morphogenesis involved in neuron differentiationGO:00486671630.013
negative regulation of nucleocytoplasmic transportGO:004682320.013
hemopoiesisGO:00300971830.013
development of primary female sexual characteristicsGO:004654540.013
actin filament polymerizationGO:003004120.013
cellular response to biotic stimulusGO:007121630.012
cortical cytoskeleton organizationGO:003086510.012
regulation of exocytosisGO:001715710.012
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.012
regulation of epithelial cell proliferationGO:005067830.012
angiogenesisGO:00015251580.012
phagocytosis engulfmentGO:000691110.012
localization of cellGO:00516742440.012
regulation of circadian rhythmGO:004275240.012
monocarboxylic acid catabolic processGO:007232930.012
embryo development ending in birth or egg hatchingGO:00097922710.012
macroautophagyGO:001623610.012
negative regulation of mapk cascadeGO:004340940.012
leukocyte proliferationGO:007066110.012
release of sequestered calcium ion into cytosolGO:005120930.012
sensory perception of painGO:001923310.012
determination of bilateral symmetryGO:00098552040.012
regulation of autophagyGO:001050630.012
brain developmentGO:00074202930.012
determination of left right symmetryGO:00073681790.012
regulation of rna biosynthetic processGO:20011412130.012
negative regulation of intracellular protein transportGO:009031730.012
regulation of anatomical structure morphogenesisGO:00226031300.012
positive regulation of cell adhesionGO:004578510.012
protein dephosphorylationGO:000647030.012
lipid oxidationGO:003444010.012
protein polymerizationGO:005125840.012
cell cycle arrestGO:000705010.012
regulation of cell substrate adhesionGO:001081010.012
mitotic dna integrity checkpointGO:004477440.012
post embryonic organ developmentGO:004856940.012
cellular component assemblyGO:00226071700.012
protein targeting to membraneGO:000661210.012
tube closureGO:006060610.012
cortical actin cytoskeleton organizationGO:003086610.012
translational initiationGO:000641330.012
embryonic organ morphogenesisGO:00485622740.012
transcription from rna polymerase ii promoterGO:0006366800.012
positive regulation of i kappab kinase nf kappab signalingGO:004312330.012
regulation of dna replicationGO:000627530.012
multi organism cellular processGO:004476420.012
eye morphogenesisGO:00485921440.012
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.012
cellular response to radiationGO:007147840.012
regulation of cell developmentGO:00602841000.012
regulation of carbohydrate metabolic processGO:000610940.012
cellular response to hypoxiaGO:007145610.012
negative regulation of protein localization to nucleusGO:190018120.012
female gonad developmentGO:000858540.012
regulation of protein complex disassemblyGO:004324410.012
positive regulation of erk1 and erk2 cascadeGO:007037420.012
cellular response to decreased oxygen levelsGO:003629410.012
nucleic acid transportGO:005065720.012
nuclear exportGO:005116810.012
mitotic cytokinesisGO:000028130.012
signal transduction in absence of ligandGO:003803410.012
developmental growthGO:00485891660.012
negative regulation of cellular catabolic processGO:003133030.012
cellular response to oxygen levelsGO:007145310.011
negative regulation of reproductive processGO:200024230.011
nucleobase containing compound transportGO:001593120.011
regulation of neuronal synaptic plasticityGO:004816810.011
developmental programmed cell deathGO:001062340.011
growthGO:00400071740.011
protein stabilizationGO:005082120.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.011
response to organic substanceGO:00100331530.011
regulation of blood pressureGO:000821710.011
regulation of stem cell differentiationGO:200073640.011
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.011
cytokinetic processGO:003250620.011
antimicrobial humoral responseGO:001973020.011
cilium assemblyGO:0042384580.011
regulation of protein bindingGO:004339330.011
mitotic dna damage checkpointGO:004477340.011
phosphatidylinositol mediated signalingGO:004801520.011
intracellular signal transductionGO:0035556850.011
xenobiotic metabolic processGO:000680540.011
organelle assemblyGO:00709251100.011
immune system developmentGO:00025201910.011
epithelial cell differentiationGO:00308551160.011
multi organism processGO:00517041340.011
regulation of microtubule cytoskeleton organizationGO:007050730.011
regulation of transmembrane transporter activityGO:002289820.011
regulation of transcription dna templatedGO:00063552130.011
positive regulation of nitrogen compound metabolic processGO:0051173690.011
phosphatidylinositol 3 kinase signalingGO:001406520.011
viral processGO:001603210.011
ameboidal type cell migrationGO:00016671430.011
hematopoietic or lymphoid organ developmentGO:00485341910.011
actin filament based movementGO:003004810.011
hormone transportGO:000991420.011
inositol lipid mediated signalingGO:004801720.011
regulation of nervous system developmentGO:0051960900.011
mononuclear cell proliferationGO:003294310.011
regulation of oocyte developmentGO:006028130.011
cellular response to lipopolysaccharideGO:007122230.011
negative regulation of cytokine productionGO:000181810.011
positive regulation of immune effector processGO:000269930.011
response to hydrogen peroxideGO:004254230.011
response to unfolded proteinGO:000698620.011
female meiotic divisionGO:000714320.010
multicellular organismal response to stressGO:003355520.010
peptidyl threonine modificationGO:001821010.010
positive regulation of cellular processGO:00485222010.010
regulation of ras gtpase activityGO:003231820.010
g protein coupled receptor signaling pathwayGO:0007186740.010
striated muscle cell differentiationGO:00511461290.010
cellular component assembly involved in morphogenesisGO:00109271070.010
cellular protein complex disassemblyGO:004362410.010
positive regulation of endothelial cell proliferationGO:000193810.010
response to alkaloidGO:004327920.010
lymphocyte proliferationGO:004665110.010
protein heterooligomerizationGO:005129110.010
regulation of cellular carbohydrate metabolic processGO:001067540.010
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.010
regulation of growth rateGO:004000910.010
negative regulation of multi organism processGO:004390130.010
establishment of rna localizationGO:005123630.010
negative regulation of defense responseGO:003134820.010
sensory perception of chemical stimulusGO:000760630.010
b cell activationGO:004211320.010
peptide metabolic processGO:000651810.010
positive regulation of epithelial cell migrationGO:001063420.010
retina development in camera type eyeGO:00600411460.010
startle responseGO:000196440.010
vacuolar transportGO:000703420.010
striated muscle cell developmentGO:00550021080.010
cellular transition metal ion homeostasisGO:004691630.010

wfs1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.037
nervous system diseaseDOID:86300.019
musculoskeletal system diseaseDOID:1700.017
disease of metabolismDOID:001466700.016
disease of cellular proliferationDOID:1456600.015
organ system cancerDOID:005068600.015
cancerDOID:16200.015
inherited metabolic disorderDOID:65500.012
sensory system diseaseDOID:005015500.012
muscular diseaseDOID:008000000.011
muscle tissue diseaseDOID:6600.010