Danio rerio

0 known processes

six4a

sine oculis homeobox homolog 4a

(Aliases: six4.2,six4b,fk50f02,wu:fk50f02)

six4a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular macromolecule biosynthetic processGO:00346452240.859
regulation of transcription dna templatedGO:00063552130.843
regulation of rna metabolic processGO:00512522240.835
regulation of primary metabolic processGO:00800903110.810
rna biosynthetic processGO:00327741810.807
sensory organ developmentGO:00074233930.771
appendage developmentGO:0048736800.761
organic cyclic compound biosynthetic processGO:19013622230.761
muscle tissue developmentGO:00605371100.760
regulation of nucleic acid templated transcriptionGO:19035062130.757
nucleic acid templated transcriptionGO:00976591810.752
regulation of nucleobase containing compound metabolic processGO:00192192500.731
macromolecule biosynthetic processGO:00090592270.718
cell fate commitmentGO:0045165990.696
nucleobase containing compound biosynthetic processGO:00346542050.686
aromatic compound biosynthetic processGO:00194382170.680
eye developmentGO:00016542770.653
cellular nitrogen compound biosynthetic processGO:00442712180.643
generation of neuronsGO:00486993850.613
olfactory bulb developmentGO:002177240.612
cellular biosynthetic processGO:00442492860.601
heart developmentGO:00075073130.586
inner ear developmentGO:00488391260.578
organic substance biosynthetic processGO:19015762890.562
cellular macromolecule metabolic processGO:00442603910.561
organic cyclic compound metabolic processGO:19013603010.553
positive regulation of biological processGO:00485182530.520
sensory organ morphogenesisGO:00905962000.514
specification of symmetryGO:00097992040.499
regulation of cellular macromolecule biosynthetic processGO:20001122220.487
positive regulation of cellular processGO:00485222010.487
cell fate specificationGO:0001708680.485
transcription dna templatedGO:00063511810.475
embryonic organ developmentGO:00485683810.447
camera type eye developmentGO:00430102220.444
eye morphogenesisGO:00485921440.439
gene expressionGO:00104672520.437
nucleic acid metabolic processGO:00903042440.431
heterocycle biosynthetic processGO:00181302150.412
ear morphogenesisGO:0042471640.405
regulation of rna biosynthetic processGO:20011412130.403
pharyngeal muscle developmentGO:004328240.402
heart loopingGO:0001947940.401
regulation of macromolecule metabolic processGO:00602553170.396
morphogenesis of an epitheliumGO:00020093330.391
regulation of macromolecule biosynthetic processGO:00105562250.390
regulation of biosynthetic processGO:00098892500.381
regulation of cellular biosynthetic processGO:00313262450.376
epidermis developmentGO:0008544480.374
nephron morphogenesisGO:007202820.372
muscle fiber developmentGO:0048747520.372
ear developmentGO:00435831270.371
regulation of gene expressionGO:00104682650.368
rna metabolic processGO:00160702190.355
forebrain developmentGO:0030900960.354
embryonic heart tube developmentGO:00350501330.354
pituitary gland developmentGO:0021983160.352
heterocycle metabolic processGO:00464832900.346
biosynthetic processGO:00090582940.345
regulation of multicellular organismal developmentGO:20000262230.343
regulation of cellular metabolic processGO:00313233200.343
cellular aromatic compound metabolic processGO:00067252950.342
central nervous system developmentGO:00074173870.333
cellular nitrogen compound metabolic processGO:00346412900.333
embryonic heart tube morphogenesisGO:00031431080.322
adenohypophysis developmentGO:0021984150.318
regulation of transcription from rna polymerase ii promoterGO:00063571140.315
determination of bilateral symmetryGO:00098552040.313
determination of heart left right asymmetryGO:00613711170.296
nucleobase containing compound metabolic processGO:00061392740.293
striated muscle tissue developmentGO:00147061100.284
heart morphogenesisGO:00030071560.284
regulation of nitrogen compound metabolic processGO:00511712510.282
positive regulation of epithelial cell differentiationGO:003085820.279
embryonic organ morphogenesisGO:00485622740.275
dorsal ventral pattern formationGO:00099531250.274
extraocular skeletal muscle developmentGO:000207430.268
retina development in camera type eyeGO:00600411460.267
nose developmentGO:004358430.266
positive regulation of macromolecule metabolic processGO:0010604930.265
compound eye developmentGO:004874920.262
positive regulation of metabolic processGO:00098931080.260
nephron tubule morphogenesisGO:007207810.257
cardiocyte differentiationGO:0035051440.247
neuron developmentGO:00486662620.234
bmp signaling pathwayGO:0030509520.234
mesoderm morphogenesisGO:0048332510.234
negative regulation of cellular processGO:00485232830.228
stem cell proliferationGO:007208940.228
regulation of developmental processGO:00507932470.226
cranial nerve developmentGO:0021545420.221
brain developmentGO:00074202930.219
transcription from rna polymerase ii promoterGO:0006366800.219
proepicardium developmentGO:000334240.216
chordate embryonic developmentGO:00430092710.213
tube morphogenesisGO:00352393490.211
regulation of organ morphogenesisGO:2000027350.210
odontogenesis of dentin containing toothGO:004247510.208
neuron differentiationGO:00301823530.201
muscle structure developmentGO:00610611960.200
regulation of metabolic processGO:00192223590.192
appendage morphogenesisGO:0035107560.192
digestive tract morphogenesisGO:00485462310.187
response to external stimulusGO:00096052640.186
renal tubule morphogenesisGO:006133310.186
axon guidanceGO:0007411860.182
neuromuscular synaptic transmissionGO:000727420.180
negative regulation of biological processGO:00485193040.176
regulation of embryonic developmentGO:0045995470.174
agingGO:000756820.171
fin developmentGO:0033333770.170
regulation of bmp signaling pathwayGO:0030510390.166
otic vesicle morphogenesisGO:0071600340.165
protein localization to nucleusGO:003450430.164
regulation of bmp signaling pathway involved in heart joggingGO:2000223120.162
nephron epithelium morphogenesisGO:007208810.160
morphogenesis of an epithelial sheetGO:0002011490.160
head developmentGO:00603223030.160
regulation of signalingGO:00230512350.159
cell part morphogenesisGO:00329902460.159
regulation of transcription from rna polymerase ii promoter involved in heart developmentGO:1901213150.155
gastrulationGO:00073692080.153
regulation of apoptotic processGO:0042981980.152
mesenchyme developmentGO:00604851270.150
determination of ventral identityGO:0048264210.148
regulation of heart morphogenesisGO:2000826170.148
positive regulation of macromolecule biosynthetic processGO:0010557590.147
pigmentationGO:0043473850.147
muscle cell differentiationGO:00426921390.146
positive regulation of gene expressionGO:0010628710.145
inner ear morphogenesisGO:0042472630.145
positive regulation of nucleobase containing compound metabolic processGO:0045935690.145
auditory receptor cell fate commitmentGO:000991240.145
cranial ganglion developmentGO:006155030.144
peripheral nervous system neuron differentiationGO:0048934280.144
myotome developmentGO:006105510.143
synaptic growth at neuromuscular junctionGO:005112420.142
positive regulation of biosynthetic processGO:0009891680.142
regulation of inner ear receptor cell differentiationGO:200098010.135
olfactory lobe developmentGO:002198840.134
heart joggingGO:0003146400.134
positive regulation of cellular biosynthetic processGO:0031328680.133
skeletal system developmentGO:00015011810.133
septum transversum developmentGO:000334340.133
negative regulation of striated muscle tissue developmentGO:004584320.130
larval developmentGO:000216420.128
regulation of epithelial cell proliferationGO:005067830.125
cell morphogenesisGO:00009022890.124
nitrogen compound metabolic processGO:00068073190.124
female sex differentiationGO:004666040.123
positive regulation of transcription dna templatedGO:0045893570.122
cell migrationGO:00164772370.122
glial cell fate specificationGO:002178040.121
positive regulation of nucleic acid templated transcriptionGO:1903508570.120
autonomic nervous system developmentGO:0048483190.120
cellular component movementGO:00069283350.119
localization of cellGO:00516742440.119
negative regulation of muscle tissue developmentGO:190186220.118
anterior posterior pattern specificationGO:00099521520.118
gland developmentGO:00487321430.117
regulation of signal transductionGO:00099662250.116
regulation of endodermal cell fate specificationGO:0042663150.115
embryo development ending in birth or egg hatchingGO:00097922710.115
positive regulation of transcription from rna polymerase ii promoterGO:0045944220.114
positive regulation of embryonic developmentGO:004001930.113
embryonic camera type eye developmentGO:0031076290.113
optomotor responseGO:007163210.112
negative regulation of muscle organ developmentGO:004863550.111
vasculature developmentGO:00019442780.110
stem cell maintenanceGO:001982740.110
lateral line system developmentGO:0048925760.110
inner ear receptor cell fate commitmentGO:006012040.108
positive regulation of cellular metabolic processGO:0031325940.108
somite developmentGO:0061053960.108
striated muscle cell differentiationGO:00511461290.107
embryonic camera type eye morphogenesisGO:0048596190.104
pectoral fin morphogenesisGO:0035138290.099
bmp signaling pathway involved in heart developmentGO:0061312150.099
regionalizationGO:00030022740.098
pancreatic d cell differentiationGO:000331120.098
retina morphogenesis in camera type eyeGO:0060042790.097
inner ear receptor cell differentiationGO:0060113290.096
positive regulation of rna metabolic processGO:0051254590.095
mesoderm developmentGO:0007498880.094
epidermal cell differentiationGO:0009913360.093
growthGO:00400071740.093
regulation of cell differentiationGO:00455951420.093
determination of left right symmetryGO:00073681790.093
heart contractionGO:0060047710.093
positive regulation of nitrogen compound metabolic processGO:0051173690.093
digestive system developmentGO:00551232890.092
pectoral fin developmentGO:0033339500.090
positive regulation of cell cycleGO:004578730.090
regulation of skeletal muscle tissue developmentGO:004864140.089
fin morphogenesisGO:0033334530.089
pronephros developmentGO:0048793690.089
posterior lateral line neuromast developmentGO:0048919200.085
blood vessel developmentGO:00015682460.084
skeletal muscle tissue developmentGO:0007519670.084
epithelial tube morphogenesisGO:00605621480.083
regulation of multicellular organismal processGO:00512392770.083
mechanoreceptor differentiationGO:0042490370.083
sensory system developmentGO:0048880760.082
regenerationGO:0031099910.082
developmental growthGO:00485891660.082
nerve developmentGO:0021675450.080
endodermal cell fate specificationGO:0001714170.080
digestive tract developmentGO:00485652650.079
epibolyGO:0090504410.078
axonogenesisGO:00074091520.078
regulation of cell deathGO:00109411030.078
neuron projection guidanceGO:0097485860.077
negative regulation of metabolic processGO:0009892860.077
neural crest cell migrationGO:0001755420.077
muscle organ developmentGO:00075171010.077
ectodermal placode developmentGO:0071696370.076
outflow tract morphogenesisGO:000315110.076
response to stressGO:00069502630.074
gliogenesisGO:0042063450.073
peripheral nervous system developmentGO:0007422550.072
cardiogenic plate morphogenesisGO:000314210.072
polarized epithelial cell differentiationGO:003085940.071
endoderm developmentGO:0007492490.071
neuron projection developmentGO:00311751800.070
embryonic skeletal system developmentGO:0048706970.070
rhombomere 5 developmentGO:002157140.070
heart processGO:0003015710.070
cellular component morphogenesisGO:00329893360.070
hematopoietic stem cell differentiationGO:0060218200.070
immune system processGO:00023762410.070
regulation of system processGO:0044057400.068
neural retina developmentGO:0003407490.068
embryonic skeletal system morphogenesisGO:0048704930.068
mesodermal cell differentiationGO:0048333210.068
response to light stimulusGO:0009416460.066
signal transductionGO:00071654550.065
connective tissue developmentGO:0061448990.064
developmental cell growthGO:0048588520.063
cellular component assemblyGO:00226071700.063
segmentationGO:0035282970.063
circulatory system processGO:0003013870.062
regulation of cell communicationGO:00106462320.062
axon developmentGO:00615641660.062
regulation of anatomical structure morphogenesisGO:00226031300.061
neural tube developmentGO:0021915620.061
regulation of mechanoreceptor differentiationGO:004563110.060
rhombomere morphogenesisGO:0021593170.059
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.058
endocrine system developmentGO:0035270650.058
trigeminal nerve developmentGO:002155930.058
response to chemicalGO:00422213200.058
embryonic hemopoiesisGO:0035162530.058
floor plate developmentGO:0033504150.057
cell surface receptor signaling pathwayGO:00071663250.057
regulation of multicellular organism growthGO:004001440.057
positive regulation of epithelial cell proliferationGO:005067910.056
cell motilityGO:00488702440.056
formation of primary germ layerGO:0001704620.055
positive regulation of rna biosynthetic processGO:1902680570.055
system processGO:00030081850.055
cartilage developmentGO:0051216960.055
negative regulation of cell differentiationGO:0045596460.055
neuroblast proliferationGO:000740520.054
stem cell differentiationGO:00488631170.054
negative regulation of macromolecule metabolic processGO:0010605760.054
oligodendrocyte cell fate specificationGO:002177840.052
rhombomere boundary formationGO:0021654100.052
central nervous system neuron differentiationGO:0021953740.052
posterior lateral line developmentGO:0048916380.052
negative regulation of gene expressionGO:0010629650.052
regulation of stem cell differentiationGO:200073640.052
peripheral nervous system neuron developmentGO:0048935220.052
growth plate cartilage developmentGO:000341720.052
negative regulation of multicellular organismal processGO:0051241690.051
blood circulationGO:0008015870.051
ectodermal placode morphogenesisGO:0071697320.050
mesodermal cell fate specificationGO:0007501120.050
renal system developmentGO:0072001940.049
photoreceptor cell differentiationGO:0046530550.049
hindbrain developmentGO:0030902910.049
ectodermal placode formationGO:0060788260.048
bmp signaling pathway involved in determination of left right symmetryGO:0003154140.048
kidney developmentGO:0001822920.048
bmp signaling pathway involved in heart joggingGO:0003303140.048
determination of dorsal ventral asymmetryGO:0048262340.047
camera type eye morphogenesisGO:00485931080.047
negative regulation of stem cell differentiationGO:200073720.047
myotube cell developmentGO:0014904350.047
rhombomere developmentGO:0021546190.046
endodermal cell differentiationGO:0035987190.046
regulation of oocyte developmentGO:006028130.045
transportGO:00068102200.045
nuclear importGO:005117030.044
cardiac chamber developmentGO:0003205190.044
glial cell migrationGO:000834730.044
cell morphogenesis involved in differentiationGO:00009041950.043
regulation of heart contractionGO:0008016320.043
mechanosensory lateral line system developmentGO:0048881490.043
regulation of cell proliferation involved in heart morphogenesisGO:200013620.043
regulation of synaptic growth at neuromuscular junctionGO:000858210.043
positive regulation of cellular component biogenesisGO:004408930.042
myotube differentiationGO:0014902450.042
axon regenerationGO:0031103140.042
inner ear receptor cell developmentGO:0060119200.042
cell deathGO:00082191210.042
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetryGO:1900094170.042
rhombomere formationGO:0021594120.042
endocardium formationGO:006021410.041
stem cell divisionGO:001714510.041
mesoderm formationGO:0001707430.041
morphogenesis of an epithelial foldGO:006057110.041
multi organism processGO:00517041340.041
positive regulation of apoptotic signaling pathwayGO:200123510.041
regulation of intracellular protein transportGO:003315730.040
endocardium morphogenesisGO:000316040.040
chemotaxisGO:00069351040.040
endocardium developmentGO:000315790.040
single organism metabolic processGO:00447102170.040
developmental pigmentationGO:0048066480.040
taxisGO:00423301090.040
regulation of organ growthGO:004662030.040
lateral line nerve glial cell developmentGO:004893760.039
cell proliferation involved in heart morphogenesisGO:006132320.039
central nervous system myelin formationGO:003228910.039
axial mesoderm developmentGO:0048318100.039
response to glucoseGO:000974930.039
oocyte developmentGO:0048599140.039
somatic stem cell maintenanceGO:003501910.039
positive regulation of transportGO:005105020.039
motor neuron axon guidanceGO:0008045230.039
regulation of epithelial cell differentiationGO:003085670.039
mesenchymal cell differentiationGO:0048762870.039
axis specificationGO:0009798430.039
negative regulation of cell communicationGO:0010648960.039
kidney epithelium developmentGO:0072073230.038
medial fin developmentGO:0033338160.038
negative regulation of cellular biosynthetic processGO:0031327550.038
regulation of cell developmentGO:00602841000.038
negative regulation of response to stimulusGO:00485851040.038
lens development in camera type eyeGO:0002088220.038
specification of organ identityGO:001009220.038
negative regulation of nitrogen compound metabolic processGO:0051172590.038
hepaticobiliary system developmentGO:0061008980.038
positive regulation of multicellular organismal processGO:0051240520.037
regulation of response to stimulusGO:00485832690.037
cell fate commitment involved in formation of primary germ layerGO:0060795260.037
sympathetic nervous system developmentGO:004848530.037
semicircular canal developmentGO:0060872240.037
rhombomere 6 developmentGO:002157240.037
otic vesicle formationGO:0030916270.037
cell surface receptor signaling pathway involved in heart developmentGO:0061311200.037
muscle cell migrationGO:001481240.036
cell morphogenesis involved in neuron differentiationGO:00486671630.036
negative regulation of signalingGO:0023057960.036
semicircular canal morphogenesisGO:0048752180.036
positive regulation of developmental processGO:0051094500.035
retina layer formationGO:0010842240.035
positive regulation of cellular catabolic processGO:003133130.035
negative regulation of signal transductionGO:0009968940.035
hair cell differentiationGO:0035315320.035
negative regulation of macromolecule biosynthetic processGO:0010558480.035
mesodermal cell fate commitmentGO:0001710140.035
regulation of gastrulationGO:0010470240.035
single organism nuclear importGO:190259330.035
forebrain generation of neuronsGO:0021872140.035
positive regulation of cell differentiationGO:0045597300.034
auditory receptor cell differentiationGO:0042491150.034
positive regulation of stem cell proliferationGO:200064810.034
otic placode formationGO:0043049230.034
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.033
endodermal cell fate commitmentGO:0001711180.033
multicellular organism reproductionGO:0032504350.033
cardiac chamber formationGO:000320740.033
regulation of synapse assemblyGO:005196330.033
lateral line nerve developmentGO:004889290.033
skeletal muscle fiber developmentGO:0048741350.033
embryonic cranial skeleton morphogenesisGO:0048701900.033
specification of axis polarityGO:006500140.033
insulin like growth factor receptor signaling pathwayGO:004800940.033
developmental programmed cell deathGO:001062340.033
cell migration in hindbrainGO:002153570.033
negative regulation of apoptotic processGO:0043066550.032
positive regulation of catabolic processGO:000989640.032
cardiac chamber morphogenesisGO:0003206120.032
ameboidal type cell migrationGO:00016671430.032
wound healingGO:0042060900.032
regulation of growthGO:0040008420.032
regulation of programmed cell deathGO:00430671010.032
embryonic limb morphogenesisGO:003032620.032
homeostasis of number of cellsGO:0048872620.032
negative regulation of biosynthetic processGO:0009890550.032
deathGO:00162651210.031
regulation of cell fate specificationGO:0042659200.031
nuclear transportGO:005116940.031
specification of organ positionGO:001015930.031
heart formationGO:0060914130.030
mesenchymal cell developmentGO:0014031780.030
gamete generationGO:0007276330.030
positive regulation of endothelial cell differentiationGO:004560320.030
single organism localizationGO:19025782250.030
cellular ketone metabolic processGO:0042180110.030
cardiac muscle tissue developmentGO:0048738480.030
anterior lateral line nerve developmentGO:004890940.030
forebrain neuron developmentGO:002188470.030
somatic muscle developmentGO:000752540.030
protein importGO:001703830.029
nephron developmentGO:0072006310.029
protein targeting to nucleusGO:004474430.029
phagocytosisGO:000690930.029
embryonic digestive tract morphogenesisGO:004855730.029
posterior lateral line neuromast hair cell differentiationGO:004892380.029
liver developmentGO:0001889960.029
endodermal cell fate determinationGO:000749320.028
tongue developmentGO:004358630.028
secondary metabolic processGO:001974830.028
skin developmentGO:0043588540.028
nucleocytoplasmic transportGO:000691340.028
cellular response to external stimulusGO:007149620.028
neural crest cell differentiationGO:0014033720.028
facial nerve developmentGO:002156130.028
cell migration involved in gastrulationGO:0042074790.028
embryonic eye morphogenesisGO:0048048300.028
embryonic epithelial tube formationGO:0001838170.028
programmed cell deathGO:00125011190.028
apoptotic processGO:00069151160.028
regulation of reproductive processGO:200024140.027
phosphorylationGO:0016310690.027
locomotionGO:00400113130.027
forebrain neuron differentiationGO:0021879140.027
muscle cell developmentGO:00550011150.026
regulation of blood circulationGO:1903522320.026
camera type eye photoreceptor cell differentiationGO:0060219190.026
neurological system processGO:0050877620.026
otic vesicle developmentGO:0071599420.026
otolith developmentGO:0048840320.026
cellular protein localizationGO:0034613200.026
embryonic camera type eye formationGO:0060900100.026
foregut morphogenesisGO:000744040.026
regulation of synapse organizationGO:005080730.026
optic cup morphogenesis involved in camera type eye developmentGO:000207270.026
negative regulation of transcription dna templatedGO:0045892450.025
negative regulation of mesodermal cell fate specificationGO:004266230.025
skeletal system morphogenesisGO:00487051020.025
columnar cuboidal epithelial cell differentiationGO:0002065380.025
positive regulation of muscle cell differentiationGO:005114910.025
mesenchymal cell proliferationGO:001046310.025
regulation of neurogenesisGO:0050767870.025
establishment of protein localization to organelleGO:007259440.025
protein complex localizationGO:003150310.025
cellular component biogenesisGO:00440851780.025
diencephalon developmentGO:0021536580.025
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.025
protein import into nucleusGO:000660630.024
regulation of cellular ketone metabolic processGO:001056570.024
negative regulation of cellular metabolic processGO:0031324770.024
negative regulation of developmental processGO:0051093650.024
regulation of mesenchymal cell proliferationGO:001046410.024
cell projection morphogenesisGO:00488582440.024
neuromast hair cell differentiationGO:0048886120.024
embryonic appendage morphogenesisGO:0035113300.024
tissue regenerationGO:0042246740.024
somitogenesisGO:0001756870.024
ventricular system developmentGO:0021591120.024
auditory receptor cell fate determinationGO:004266820.024
oocyte maturationGO:000155640.024
epithelial cell differentiationGO:00308551160.024
pancreatic a cell developmentGO:000332220.023
epithelial cell fate commitmentGO:0072148110.023
single organism cellular localizationGO:1902580460.023
positive regulation of signal transductionGO:0009967560.023
positive regulation of cytokine productionGO:000181920.023
type b pancreatic cell developmentGO:000332340.023
pericardium developmentGO:006003910.023
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.023
regulation of establishment of protein localizationGO:007020140.023
epidermal cell fate specificationGO:000995740.023
developmental growth involved in morphogenesisGO:0060560860.023
cellular response to estrogen stimulusGO:0071391240.022
phosphatidylinositol mediated signalingGO:004801520.022
keratinocyte differentiationGO:003021600.022
positive regulation of dna metabolic processGO:005105410.022
cell projection organizationGO:00300302840.022
cell cycleGO:0007049930.022
neuron projection morphogenesisGO:00488121610.022
positive regulation of signalingGO:0023056560.022
striated muscle cell proliferationGO:001485570.022
macromolecule localizationGO:0033036540.022
convergent extensionGO:00600261180.022
organ growthGO:0035265120.022
extrinsic apoptotic signaling pathwayGO:009719130.022
positive regulation of neuron deathGO:190121610.022
protein localizationGO:0008104400.022

six4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.210
nervous system diseaseDOID:86300.050
connective tissue diseaseDOID:6500.049
bone diseaseDOID:008000100.049
musculoskeletal system diseaseDOID:1700.049
bone development diseaseDOID:008000600.034